silicosis

Summary

Summary: A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.

Top Publications

  1. Mulenga E, Miller H, Sinkala T, Hysong T, Burgess J. Silicosis and tuberculosis in Zambian miners. Int J Occup Environ Health. 2005;11:259-62 pubmed
    b>Silicosis and tuberculosis (TB) are significant mining-related illnesses in developing countries...
  2. Beamer C, Holian A. Antigen-presenting cell population dynamics during murine silicosis. Am J Respir Cell Mol Biol. 2007;37:729-38 pubmed
    b>Silicosis is an occupational lung disease resulting from the inhalation of silica particles over prolonged periods of time, which causes chronic inflammation and progressive pulmonary fibrosis...
  3. Sirajuddin A, Kanne J. Occupational lung disease. J Thorac Imaging. 2009;24:310-20 pubmed publisher
    ..Although silicosis and coal worker's pneumoconiosis are becoming less common, hypersensitivity pneumonitis is increasingly ..
  4. Amabile J, Leuraud K, Vacquier B, Caër Lorho S, Acker A, Laurier D. Multifactorial study of the risk of lung cancer among French uranium miners: radon, smoking and silicosis. Health Phys. 2009;97:613-21 pubmed publisher
    This case-control study nested in the French cohort of uranium miners provides an opportunity to take account of silicosis and smoking in the assessment of the relation between radon and lung cancer...
  5. Mohebbi I, Lameei A, Booshehri B, Aslanabadi N, Maasomi R, Dehghani M. Pericardial plaque: a unique complication of silicosis. Ind Health. 2011;49:122-5 pubmed
    ..This unique case of silicosis complicated by corpulmonale associated with pericardial plaque formation in a young adult male is reported here ..
  6. Wang C, Yang L, Shi X, Yang Y, Liu K, Liu R. Depressive symptoms in aged Chinese patients with silicosis. Aging Ment Health. 2008;12:343-8 pubmed publisher
    To investigate the prevalence of depressive symptoms in patients with silicosis and its determinants. A cross-sectional cohort study was performed...
  7. Marchiori E, Ferreira A, Saez F, Gabetto J, Souza A, Escuissato D, et al. Conglomerated masses of silicosis in sandblasters: high-resolution CT findings. Eur J Radiol. 2006;59:56-9 pubmed
    The purpose of this study was to describe the high-resolution CT aspects of the silicosis and progressive massive fibrosis in sandblasters...
  8. Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, et al. IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis. J Immunol. 2010;184:6367-77 pubmed publisher
    ..Upregulation of IL-17A was associated with the development of experimental silicosis, but this response was markedly reduced in athymic, gammadelta T cell-deficient or CD4(+) T cell-depleted mice...
  9. Park H, Girdler Brown B, Churchyard G, White N, Ehrlich R. Incidence of tuberculosis and HIV and progression of silicosis and lung function impairment among former Basotho gold miners. Am J Ind Med. 2009;52:901-8 pubmed publisher
    Pulmonary tuberculosis and HIV incidence, mortality, and the progression of silicosis and lung function impairment are described over a 1-year period in migrant ex-gold miners from Lesotho...

More Information

Publications62

  1. Huaux F. New developments in the understanding of immunology in silicosis. Curr Opin Allergy Clin Immunol. 2007;7:168-73 pubmed
    ..evidence that the immune responses induced by crystalline silica particles are implicated in the development of silicosis. This article reviews recent observations which further delineate how innate and adaptive immunity are involved ..
  2. Lahiri S, Levenstein C, Nelson D, Rosenberg B. The cost effectiveness of occupational health interventions: prevention of silicosis. Am J Ind Med. 2005;48:503-14 pubmed
    ..In this paper, we present an analysis of the cost effectiveness of alternative means of preventing silicosis. To evaluate the cost effectiveness of specific interventions for the prevention of occupationally induced ..
  3. Cimrin A, Sigsgaard T, Nemery B. Sandblasting jeans kills young people. Eur Respir J. 2006;28:885-6 pubmed
  4. Zielonka T, Demkow U, Filewska M, Bialas Chromiec B, Zycinska K, Radzikowska E, et al. Angiogenic activity of sera from silicosis and pulmonary Langerhans cell histiocytosis patients in relation to lung function tests. J Physiol Pharmacol. 2008;59 Suppl 6:781-9 pubmed
    ..has been described, but the role of angiogenesis in the pathogenesis of other interstitial lung diseases such as silicosis and pulmonary Langerhans cell histiocytosis remains unclear...
  5. Chen W, Hnizdo E, Chen J, Attfield M, Gao P, Hearl F, et al. Risk of silicosis in cohorts of Chinese tin and tungsten miners, and pottery workers (I): an epidemiological study. Am J Ind Med. 2005;48:1-9 pubmed
    Epidemiological evaluations of the risk of silicosis in relation to exposure to crystalline silica have raised the question of whether different types of silica dust exposures vary with respect to their ability to cause silicosis...
  6. Mazurek J, Attfield M. Silicosis mortality among young adults in the United States, 1968-2004. Am J Ind Med. 2008;51:568-78 pubmed publisher
    To describe silicosis deaths in young (aged 15-44) adults in the U.S. during 1968-2004. We analyzed the National Center for Health Statistics multiple cause-of-death records...
  7. Otsuki T, Maeda M, Murakami S, Hayashi H, Miura Y, Kusaka M, et al. Immunological effects of silica and asbestos. Cell Mol Immunol. 2007;4:261-8 pubmed
    b>Silicosis patients (SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders...
  8. Barboza C, Winter D, Seiscento M, Santos U, Terra Filho M. Tuberculosis and silicosis: epidemiology, diagnosis and chemoprophylaxis. J Bras Pneumol. 2008;34:959-66 pubmed
    b>Silicosis, the most prevalent of the pneumoconioses, is caused by inhalation of crystalline silica particles...
  9. Rees D, Murray J, Nelson G, Sonnenberg P. Oscillating migration and the epidemics of silicosis, tuberculosis, and HIV infection in South African gold miners. Am J Ind Med. 2010;53:398-404 pubmed publisher
    ..This is termed oscillating or circular migration. Today we have serious interrelated epidemics of silicosis, tuberculosis, and HIV infection in the gold mining industry...
  10. Giordano G, van den Brule S, Lo Re S, Triqueneaux P, Uwambayinema F, Yakoub Y, et al. Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis. Toxicol Sci. 2010;116:682-92 pubmed publisher
    ..Type I IFN is, however, dispensable in the development of silica-induced acute lung inflammation and pulmonary fibrosis. ..
  11. Lassance R, Prota L, Maron Gutierrez T, Garcia C, Abreu S, Passaro C, et al. Intratracheal instillation of bone marrow-derived cell in an experimental model of silicosis. Respir Physiol Neurobiol. 2009;169:227-33 pubmed publisher
    ..mediators are analysed after intratracheal instillation (IT) of bone marrow-derived cells (BMDC) in a model of silicosis. C57BL/6 mice were randomly divided into SIL (silica, 20mg IT) and control (CTRL) groups (saline IT)...
  12. Rees D, Murray J. Silica, silicosis and tuberculosis. Int J Tuberc Lung Dis. 2007;11:474-84 pubmed
    Exposure to crystalline silica dust causes multiple diseases, but silicosis and silica dust-associated tuberculosis (TB), in particular, are the two diseases that remain high on the list of occupational health priorities in low-income ..
  13. Martinez C, Prieto A, Garcia L, Quero A, Gonzalez S, Casan P. Silicosis: a disease with an active present. Arch Bronconeumol. 2010;46:97-100 pubmed publisher
    b>Silicosis, an interstitial lung disease caused by the inhalation of crystalline silica powder, despite being one of the oldest occupational diseases, continues being a cause of morbidity and mortality all over the world...
  14. Fang G, Fan X, Shen F. The relationship between polymorphisms of interleukin-4 gene and silicosis. Biomed Environ Sci. 2011;24:678-82 pubmed publisher
    ..between polymorphisms of interleukin-4 (IL-4) gene (-33, +45, intron3, +429, +448) and the susceptibility of silicosis. A case-control study was carried out. 101 silicosis patients were selected as cases...
  15. Santos C, Norte A, Fradinho F, Catarino A, Ferreira A, Loureiro M, et al. Silicosis - brief review and experience of a pulmonology ward. Rev Port Pneumol. 2010;16:99-115 pubmed
    b>Silicosis is a diffuse interstitial fibronodular lung disease, caused by the inhalation of crystalline silica...
  16. Chong S, Lee K, Chung M, Han J, Kwon O, Kim T. Pneumoconiosis: comparison of imaging and pathologic findings. Radiographics. 2006;26:59-77 pubmed
    ..b>Silicosis, coal worker pneumoconiosis, asbestosis, berylliosis, and talcosis are examples of fibrotic pneumoconiosis...
  17. Lopes A, Mogami R, Capone D, Tessarollo B, de Melo P, Jansen J. High-resolution computed tomography in silicosis: correlation with chest radiography and pulmonary function tests. J Bras Pneumol. 2008;34:264-72 pubmed
    ..as to compare chest X-ray findings with high resolution computed tomography (HRCT) findings, in patients with silicosis. A cross-sectional study was conducted in 44 non-smoking patients without a history of tuberculosis...
  18. Akgun M, Kantarci M, Araz O, Ucar E, Mirici A. Medical image. Silicosis due to denim sandblasting: multidetector CT findings. N Z Med J. 2008;121:69-71 pubmed
  19. Qu Y, Tang Y, Cao D, Wu F, Liu J, Lu G, et al. Genetic polymorphisms in alveolar macrophage response-related genes, and risk of silicosis and pulmonary tuberculosis in Chinese iron miners. Int J Hyg Environ Health. 2007;210:679-89 pubmed
    ..investigate the roles of AMs response-related genes TNF-alpha, iNOS, and NRAMP1 (SLC11A1) in susceptibility to silicosis and pulmonary tuberculosis (PTB), and to analyze the interaction of dust exposure and genetic susceptibility to ..
  20. Gao H, Rong Xue -, Peng Ding -, Chen N, Bing Meng -, Zhao H, et al. Cross-talk of the related bioactivity mediators in serum after injection of soluble TNF-? receptor on silicosis model of rats. Toxicol Ind Health. 2011;27:607-16 pubmed publisher
    ..It may be concluded that soluble TNF-? receptor upregulating or downregulating the expression of the related bioactivity mediators results in decreasing lung injury induced by silica. ..
  21. Marchiori E, Souza C, Barbassa T, Escuissato D, Gasparetto E, Souza A. Silicoproteinosis: high-resolution CT findings in 13 patients. AJR Am J Roentgenol. 2007;189:1402-6 pubmed
    ..Silicoproteinosis usually manifests as bilateral consolidation in the posterior portions of the lungs and as numerous centrilobular nodules. Calcification within areas of consolidation is a common finding. ..
  22. Miao R, Zhang X, Yan Y, He E, Guo P, Zhang Y, et al. [Change of serum TGF-beta1 and TNF-alpha in silicosis patients]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011;29:606-7 pubmed
    To observe serum TGF-beta1 and TNF-alpha in silicosis patients and workers exposed to silica dust to study the role of TGF-beta1 and TNF-alpha in the development of silicosis...
  23. Peretz A, Checkoway H, Kaufman J, Trajber I, Lerman Y. Silica, silicosis, and lung cancer. Isr Med Assoc J. 2006;8:114-8 pubmed
    ..The decision raised a debate in the scientific arena, and a few scientists have questioned the basis upon which causality was determined. We review the literature regarding the level of evidence of crystalline silica carcinogenicity. ..
  24. Parakh U, Sinha R, Bhatnagar A, Singh P. Chronic necrotising pulmonary aspergillosis: a rare complication in a case of silicosis. Indian J Chest Dis Allied Sci. 2005;47:199-203 pubmed
    Chronic necrotising pulmonary aspergillosis (CNPA) is a rare complication of silicosis whose diagnosis requires a high index of suspicion as it mimics tuberculosis...
  25. Iossifova Y, Bailey R, Wood J, Kreiss K. Concurrent silicosis and pulmonary mycosis at death. Emerg Infect Dis. 2010;16:318-20 pubmed publisher
    To examine risk for mycosis among persons with silicosis, we examined US mortality data for 1979-2004...
  26. Beamer C, Migliaccio C, Jessop F, Trapkus M, Yuan D, Holian A. Innate immune processes are sufficient for driving silicosis in mice. J Leukoc Biol. 2010;88:547-57 pubmed publisher
    ..Although the cellular mechanisms and anatomical consequences involved in the development of silicosis have been studied extensively, they still remain poorly understood...
  27. Sato T, Takeno M, Honma K, Yamauchi H, Saito Y, Sasaki T, et al. Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury. Am J Respir Crit Care Med. 2006;174:906-14 pubmed
    ..We examined whether HO-1 might be involved in silicosis. To investigate whether HO-1 can reduce silicosis in mice and humans...
  28. Greenberg M, Waksman J, Curtis J. Silicosis: a review. Dis Mon. 2007;53:394-416 pubmed
  29. Wu F, Qu Y, Tang Y, Cao D, Sun P, Xia Z. Lack of association between cytokine gene polymorphisms and silicosis and pulmonary tuberculosis in Chinese iron miners. J Occup Health. 2008;50:445-54 pubmed
    b>Silicosis is a fibrotic lung disease produced by the inhalation and deposition of silica dust. The association between silicosis and pulmonary tuberculosis (PTB) has been well established...
  30. Ramsgaard L, Englert J, Tobolewski J, Tomai L, Fattman C, Leme A, et al. The role of the receptor for advanced glycation end-products in a murine model of silicosis. PLoS ONE. 2010;5:e9604 pubmed publisher
    ..Aside from the difference in the fibrotic pattern, these studies showed no indicators of RAGE having an effect on the severity of pulmonary fibrosis following silica injury. ..
  31. Harrison J, Chen J, Miller W, Chen W, Hnizdo E, Lu J, et al. Risk of silicosis in cohorts of Chinese tin and tungsten miners and pottery workers (II): Workplace-specific silica particle surface composition. Am J Ind Med. 2005;48:10-5 pubmed
    ..In conjunction with an epidemiological investigation of silicosis disease risk in Chinese tin and tungsten mine and pottery workplaces, we analyzed respirable silica dusts using ..
  32. Sato T, Shimosato T, Alvord W, Klinman D. Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation. J Immunol. 2008;180:7648-54 pubmed
    Inhalation of silica-containing dust particles induces silicosis, an inflammatory disease of the lungs characterized by the infiltration of macrophages and neutrophils into the lungs and the production of proinflammatory cytokines, ..
  33. Lakatos H, Burgess H, Thatcher T, Redonnet M, Hernady E, Williams J, et al. Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation. Exp Lung Res. 2006;32:181-99 pubmed
    ..Oropharyngeal aspiration should be considered as an alternative to intratracheal instillation of silica and other particulates in studies of respiratory toxicity and lung disease...
  34. Chen Y, Chen J, Dong J, Liu W. Antifibrotic effect of interferon gamma in silicosis model of rat. Toxicol Lett. 2005;155:353-60 pubmed
    This study presents the antifibrotic effect of interferon gamma (IFN-gamma) in silicosis of rats. Wistar rats were received saline or 20 mg of quartz by intratracheal instillation...
  35. Li L, Yu C, Qi F, Li D, Liu B. [Potential effect of tumor necrosis factor-alpha and tumor necrosis factor receptor II gene polymorphisms on the pathogenesis of silicosis]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004;22:323-6 pubmed
    ..TNF-alpha) and tumor necrosis factor receptor II (TNFR II) gene polymorphisms in genetic susceptibility to silicosis and their interaction with silica-dust exposure...
  36. Bang K, Attfield M, Wood J, Syamlal G. National trends in silicosis mortality in the United States, 1981-2004. Am J Ind Med. 2008;51:633-9 pubmed publisher
    This article describes trends in mortality with silicosis and identifies industries and occupations with elevated silicosis mortality...
  37. Langley R, Mishra N, Pena Philippides J, Rice B, Seagrave J, Singh S, et al. Fibrogenic and redox-related but not proinflammatory genes are upregulated in Lewis rat model of chronic silicosis. J Toxicol Environ Health A. 2011;74:1261-79 pubmed publisher
    b>Silicosis, a fibrotic granulomatous lung disease, may occur through accidental high-dose or occupational inhalation of silica, leading to acute/accelerated and chronic silicosis, respectively...
  38. Wu P, Miura Y, Hyodoh F, Nishimura Y, Hatayama T, Hatada S, et al. Reduced function of CD4+25+ regulatory T cell fraction in silicosis patients. Int J Immunopathol Pharmacol. 2006;19:357-68 pubmed
    The quality and quantity of CD4+25+ regulatory T cells (Treg) in silicosis patients (SIL) were examined and compared with results from healthy donors (HD) because SIL often develop autoimmune diseases along with pulmonary disorders...
  39. Leung C, Yu I, Chen W. Silicosis. Lancet. 2012;379:2008-18 pubmed publisher
    b>Silicosis is a fibrotic lung disease caused by inhalation of free crystalline silicon dioxide or silica. Occupational exposure to respirable crystalline silica dust particles occurs in many industries...
  40. Lee E, Lee E, Kim H, Jang A, Koh E, Uh S, et al. Overexpression of apolipoprotein A1 in the lung abrogates fibrosis in experimental silicosis. PLoS ONE. 2013;8:e55827 pubmed publisher
    The inhalation of silica particles induces silicosis, an inflammatory and fibrotic lung disease characterized by the early accumulation of macrophages and neutrophils in the airspace and subsequent appearance of silicotic nodules as a ..
  41. Umemura S, Fujimoto N, Hiraki A, Gemba K, Takigawa N, Fujiwara K, et al. Aberrant promoter hypermethylation in serum DNA from patients with silicosis. Carcinogenesis. 2008;29:1845-9 pubmed publisher
    It is well established that patients with silicosis are at high risk for lung cancer; however, it is difficult to detect lung cancer by chest radiography during follow-up treatment of patients with silicosis because of preexisting ..
  42. Akgun M, Araz O, Akkurt I, Eroglu A, Alper F, Saglam L, et al. An epidemic of silicosis among former denim sandblasters. Eur Respir J. 2008;32:1295-303 pubmed publisher
    Sandblasting denim using silica has emerged as a new cause of silicosis in Turkey...
  43. Girdler Brown B, White N, Ehrlich R, Churchyard G. The burden of silicosis, pulmonary tuberculosis and COPD among former Basotho goldminers. Am J Ind Med. 2008;51:640-7 pubmed publisher
    The burden of silicosis, pulmonary tuberculosis and COPD is described in 624 South African gold miners 18 months after cessation of work. This was a prevalence study...
  44. Nelson G, Girdler Brown B, Ndlovu N, Murray J. Three decades of silicosis: disease trends at autopsy in South African gold miners. Environ Health Perspect. 2010;118:421-6 pubmed publisher
    Eliminating silicosis is a priority of the International Labour Organization and the World Health Organization. Prevalence is particularly high in developing countries...
  45. CASSEL S, Eisenbarth S, Iyer S, Sadler J, Colegio O, Tephly L, et al. The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A. 2008;105:9035-40 pubmed publisher
    Inhalation of crystalline silica and asbestos is known to cause the progressive pulmonary fibrotic disorders silicosis and asbestosis, respectively...
  46. Akgun M, Mirici A, Ucar E, Kantarci M, Araz O, Gorguner M. Silicosis in Turkish denim sandblasters. Occup Med (Lond). 2006;56:554-8 pubmed
    Sandblasting of jeans in small Turkish workshops has recently been recognized as a cause of silicosis. Between August 2004 and March 2006, we admitted 16 young men with a history of working in small workplaces producing sandblasted jeans...
  47. Misson P, Brombacher F, Delos M, Lison D, Huaux F. Type 2 immune response associated with silicosis is not instrumental in the development of the disease. Am J Physiol Lung Cell Mol Physiol. 2007;292:L107-13 pubmed
    ..We found that IL-4(-/-) mice were not protected against the development of silicosis, suggesting that IL-4 is not essential for the development of this fibrotic disease...
  48. Zhai R, Ge X, Li H, Tang Z, Liao R, Kleinjans J. Differences in cellular and inflammatory cytokine profiles in the bronchoalveolar lavage fluid in bagassosis and silicosis. Am J Ind Med. 2004;46:338-44 pubmed
    ..was to characterize the cellular and cytokine patterns in the airways of bagassosis and to compare these with silicosis subjects and controls...
  49. Di Giuseppe M, Gambelli F, Hoyle G, Lungarella G, Studer S, Richards T, et al. Systemic inhibition of NF-kappaB activation protects from silicosis. PLoS ONE. 2009;4:e5689 pubmed publisher
    b>Silicosis is a complex lung disease for which no successful treatment is available and therefore lung transplantation is a potential alternative...
  50. Glynn J, Murray J, Bester A, Nelson G, Shearer S, Sonnenberg P. Effects of duration of HIV infection and secondary tuberculosis transmission on tuberculosis incidence in the South African gold mines. AIDS. 2008;22:1859-67 pubmed publisher
    ..We assess the contribution of these two mechanisms by time since seroconversion to HIV...
  51. Gupta K, Manchanda M, Kaur P. Bilateral spontaneous pneumothorax in silicosis. Indian J Chest Dis Allied Sci. 2006;48:201-3 pubmed
    Occurrence of pneumothorax in silicosis is rare and when it occurs, pneumothorax is usually unilateral. We report here a patient with accelerated silicosis who presented with bilateral spontaneous pneumothoraces occurring simultaneously...
  52. Wang D, Yang Y, Xia Q, Lan Y, Wang M, Zhang X, et al. [On the association of tumor necrosis factor-alpha gene polymorphisms with the susceptibility to silicosis]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005;36:679-82, 712 pubmed
    ..within the tumor necrosis factor-alpha gene (TNF-alpha) promoter region are associated with susceptibility to silicosis in the Han population of southwest China...
  53. Arakawa H, Gevenois P, Saito Y, Shida H, De Maertelaer V, Morikubo H, et al. Silicosis: expiratory thin-section CT assessment of airway obstruction. Radiology. 2005;236:1059-66 pubmed
    ..if findings on paired inspiratory and expiratory thin-section computed tomographic (CT) scans in patients with silicosis correlate with pulmonary function test results...