Summary: A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.

Top Publications

  1. Franko A, Dolzan V, Arneric N, Dodic Fikfak M. Asbestosis and catalase genetic polymorphism. Arh Hig Rada Toksikol. 2008;59:233-40 pubmed publisher
    ..the enzymatic defense system against reactive oxygen species (ROS), known to be involved in the pathogenesis of asbestosis. This study investigates whether CAT -262 C>T genetic polymorphism influences the risk of asbestosis in ..
  2. Sabo Attwood T, Ramos Nino M, Bond J, Butnor K, Heintz N, Gruber A, et al. Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis. Am J Pathol. 2005;167:1243-56 pubmed
    ..Identification of genes involved in lung injury and remodeling after asbestos exposure could aid in defining mechanisms of airborne particulate-induced disease and in developing therapeutic strategies. ..
  3. Jamrozik E, de Klerk N, Musk A. Asbestos-related disease. Intern Med J. 2011;41:372-80 pubmed publisher
    Inhalation of airborne asbestos fibres causes several diseases. These include asbestosis, lung cancer, malignant mesothelioma as well as pleural effusion, discrete (plaques) or diffuse benign pleural fibrosis and rolled atelectasis...
  4. Uibu T, Vanhala E, Sajantila A, Lunetta P, Mäkelä Bengs P, Goebeler S, et al. Asbestos fibers in para-aortic and mesenteric lymph nodes. Am J Ind Med. 2009;52:464-70 pubmed publisher
    ..We assessed the presence of asbestos in the para-aortic (PA) and mesenteric (ME) lymph nodes...
  5. Kurumatani N, Kumagai S. Mapping the risk of mesothelioma due to neighborhood asbestos exposure. Am J Respir Crit Care Med. 2008;178:624-9 pubmed publisher
    ..Little is known about neighborhood exposure to asbestos and mesothelioma risk among residents around an industrial source of asbestos...
  6. Becklake M, Bagatin E, Neder J. Asbestos-related diseases of the lungs and pleura: uses, trends and management over the last century. Int J Tuberc Lung Dis. 2007;11:356-69 pubmed
    ..As its ill-health effects, both non-malignant (fibrosis of the lungs or asbestosis; pleural effusion, plaques and thickening) and malignant (mesothelioma, lung and other cancers), became evident, ..
  7. Akira M. High-resolution CT in the evaluation of occupational and environmental disease. Radiol Clin North Am. 2002;40:43-59 pubmed
    The most common of the pneumoconioses are silicosis, CWP, and asbestosis. The former two are characterized by the presence of small nodular opacities predominantly distributed in the upper zones of the lung...
  8. Stayner L, Kuempel E, Gilbert S, Hein M, Dement J. An epidemiological study of the role of chrysotile asbestos fibre dimensions in determining respiratory disease risk in exposed workers. Occup Environ Med. 2008;65:613-9 pubmed
    ..TEM-based cumulative exposure estimates were found to provide stronger predictions of asbestosis and lung cancer mortality than PCM-based estimates...
  9. White N, Nelson G, Murray J. South African experience with asbestos related environmental mesothelioma: is asbestos fiber type important?. Regul Toxicol Pharmacol. 2008;52:S92-6 pubmed
    ..Crocidolite appears to be far more mesotheliomagenic than amosite, and chrysotile has not been implicated in the disease. This is true for both occupationally and environmentally exposed individuals. ..

More Information


  1. Reid A, de Klerk N, Ambrosini G, Olsen N, Pang S, Musk A. The additional risk of malignant mesothelioma in former workers and residents of Wittenoom with benign pleural disease or asbestosis. Occup Environ Med. 2005;62:665-9 pubmed
    To examine the hypothesis that people with benign pleural disease or asbestosis have an increased risk of malignant mesothelioma beyond that attributable to their degree of asbestos exposure...
  2. Tarrés J, Abós Herràndiz R, Alberti C, Martínez Artés X, Rosell Murphy M, García Allas I, et al. [Asbestos-related diseases in a population near a fibrous cement factory]. Arch Bronconeumol. 2009;45:429-34 pubmed publisher
    ..The number of cases of asbestos-related diseases detected annually showed an upward trend. The incidence was extremely high in the period studied. ..
  3. Horton D, Bove F, Kapil V. Select mortality and cancer incidence among residents in various U.S. communities that received asbestos-contaminated vermiculite ore from Libby, Montana. Inhal Toxicol. 2008;20:767-75 pubmed
    In response to the significantly elevated asbestosis mortality rates found in Libby, Montana, in 2000, this analysis evaluated whether other communities throughout the United States that received asbestos-contaminated vermiculite ore from ..
  4. Pass H, Lott D, Lonardo F, Harbut M, Liu Z, Tang N, et al. Asbestos exposure, pleural mesothelioma, and serum osteopontin levels. N Engl J Med. 2005;353:1564-73 pubmed
    ..4 ng of osteopontin per milliliter. Serum osteopontin levels can be used to distinguish persons with exposure to asbestos who do not have cancer from those with exposure to asbestos who have pleural mesothelioma. ..
  5. Nelson G, Murray J, Phillips J. The risk of asbestos exposure in South African diamond mine workers. Ann Occup Hyg. 2011;55:569-77 pubmed publisher
    ..Very little is known about the health risks in the diamond mining industry. The objective of this study was to explore the possibility of asbestos exposure during the process of diamond mining...
  6. Chow S, Campbell C, Sandrini A, Thomas P, Johnson A, Yates D. Exhaled breath condensate biomarkers in asbestos-related lung disorders. Respir Med. 2009;103:1091-7 pubmed publisher
    ..Eighty six men were studied: sixty subjects with asbestos-related disorders (asbestosis: 18, diffuse pleural thickening (DPT): 16, pleural plaques (PPs): 26) and twenty six age- and gender-matched ..
  7. Manning C, Sabo Attwood T, Robledo R, Macpherson M, Rincon M, Vacek P, et al. Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestos. Am J Respir Cell Mol Biol. 2008;38:618-26 pubmed publisher
    ..These results suggest a critical role of MEK1 signaling in epithelial cell proliferation and lung remodeling after toxic injury...
  8. Toyokuni S. Mechanisms of asbestos-induced carcinogenesis. Nagoya J Med Sci. 2009;71:1-10 pubmed
    ..Elucidation of the major mechanisms underlying DMM would be helpful for the development of novel strategies to prevent DMM induction in people who have already been exposed to asbestos. ..
  9. Braun L, Kisting S. Asbestos-related disease in South Africa: the social production of an invisible epidemic. Am J Public Health. 2006;96:1386-96 pubmed
  10. Roggli V, Vollmer R. Twenty-five years of fiber analysis: what have we learned?. Hum Pathol. 2008;39:307-15 pubmed publisher
    Asbestos exposure has resulted in a variety of diseases, including asbestosis, carcinoma of the lung (LC), pleural plaques, and malignant mesothelioma (MM)...
  11. Price B. Exposure to airborne amphibole structures and health risks: Libby, Montana. Regul Toxicol Pharmacol. 2008;52:S97-S109 pubmed
    ..Libby residents' exposures typically are substantially lower than mine workers' historical exposures, and the health risk projections for residents are, accordingly, substantially lower...
  12. Nishimura Y, Miura Y, Maeda M, Hayashi H, Dong M, Katsuyama H, et al. Expression of the T cell receptor Vbeta repertoire in a human T cell resistant to asbestos-induced apoptosis and peripheral blood T cells from patients with silica and asbestos-related diseases. Int J Immunopathol Pharmacol. 2006;19:795-805 pubmed
    ..Patients with asbestos-related diseases (ARD), such as asbestosis and malignant mesothelioma, were compared with silicosis (SIL) patients as a disease control and with healthy ..
  13. Schneider F, Sporn T, Roggli V. Asbestos fiber content of lungs with diffuse interstitial fibrosis: An analytical scanning electron microscopic analysis of 249 cases. Arch Pathol Lab Med. 2010;134:457-61 pubmed publisher
    b>Asbestosis is one of many forms of diffuse interstitial pulmonary fibrosis. Its histologic diagnosis rests on the pattern of fibrosis and the presence of asbestos bodies by light microscopy in lung biopsies...
  14. Liu G, Beri R, Mueller A, Kamp D. Molecular mechanisms of asbestos-induced lung epithelial cell apoptosis. Chem Biol Interact. 2010;188:309-18 pubmed publisher
    Asbestos causes pulmonary fibrosis (asbestosis) and malignancies (bronchogenic lung cancer and mesothelioma) by mechanisms that are not fully elucidated...
  15. O Reilly K, McLaughlin A, Beckett W, Sime P. Asbestos-related lung disease. Am Fam Physician. 2007;75:683-8 pubmed
    The inhalation of asbestos fibers may lead to a number of respiratory diseases, including lung cancer, asbestosis, pleural plaques, benign pleural effusion, and malignant mesothelioma...
  16. Courtice M, Lin S, Wang X. An updated review on asbestos and related diseases in China. Int J Occup Environ Health. 2012;18:247-53 pubmed publisher
    Asbestos is an industrial mineral that can cause diseases such as asbestosis, lung cancer, and mesothelioma. Asbestos consumption in China has increased steadily since the 1960s and is currently at half a million tonnes per year...
  17. Yasumitsu A, Tabata C, Tabata R, Hirayama N, Murakami A, Yamada S, et al. Clinical significance of serum vascular endothelial growth factor in malignant pleural mesothelioma. J Thorac Oncol. 2010;5:479-83 pubmed publisher
    ..of VEGF were measured in 51 patients with MPM and 42 individuals with benign asbestos-related diseases (asbestosis or pleural plaques) or who were healthy despite asbestos exposure...
  18. Borelli V, Brochetta C, Melato M, Rizzardi C, Polentarutti M, Busatto C, et al. A procedure for the isolation of asbestos bodies from lung tissue by exploiting their magnetic properties: a new approach to asbestos body study. J Toxicol Environ Health A. 2007;70:1232-40 pubmed
  19. Tabata C, Hirayama N, Tabata R, Yasumitsu A, Yamada S, Murakami A, et al. A novel clinical role for angiopoietin-1 in malignant pleural mesothelioma. Eur Respir J. 2010;36:1099-105 pubmed publisher
    ..We propose the possibility that Ang-1 plays an important role in MPM tumour growth and our data suggest that the serum concentration of Ang-1 could be useful as prognostic factor. ..
  20. Alexander B, Raleigh K, Johnson J, Mandel J, Adgate J, Ramachandran G, et al. Radiographic evidence of nonoccupational asbestos exposure from processing Libby vermiculite in Minneapolis, Minnesota. Environ Health Perspect. 2012;120:44-9 pubmed publisher
    ..These results support the hypothesis that community exposure to asbestos-contaminated vermiculite originating from Libby, Montana, is associated with measurable effects based on radiographic evidence. ..
  21. Dodson R, Shepherd S, Levin J, Hammar S. Characteristics of asbestos concentration in lung as compared to asbestos concentration in various levels of lymph nodes that collect drainage from the lung. Ultrastruct Pathol. 2007;31:95-133 pubmed
    ..When a long/thin fiber was found in the lung or lymph tissue, its detection required the use of analytical transmission electron microscopy for identification...
  22. Deng Q, Wang X, Wang M, Lan Y. Exposure-response relationship between chrysotile exposure and mortality from lung cancer and asbestosis. Occup Environ Med. 2012;69:81-6 pubmed publisher
    ..and determine exposure-response relationships between asbestos exposure and mortality from lung cancer and asbestosis by fitting and comparing different models...
  23. Pascolo L, Gianoncelli A, Kaulich B, Rizzardi C, Schneider M, Bottin C, et al. Synchrotron soft X-ray imaging and fluorescence microscopy reveal novel features of asbestos body morphology and composition in human lung tissues. Part Fibre Toxicol. 2011;8:7 pubmed publisher
  24. Mastrangelo G, Ballarin M, Bellini E, Bicciato F, Zannol F, Gioffrè F, et al. Asbestos exposure and benign asbestos diseases in 772 formerly exposed workers: dose-response relationships. Am J Ind Med. 2009;52:596-602 pubmed publisher
  25. Harding A, Darnton A. Asbestosis and mesothelioma among British asbestos workers (1971-2005). Am J Ind Med. 2010;53:1070-80 pubmed publisher
    Ascertainment of asbestosis and mesothelioma from underlying cause of death underestimates the burden of these diseases...
  26. Corradi M, Goldoni M, Alinovi R, Tiseo M, Ampollini L, Bonini S, et al. YKL-40 and mesothelin in the blood of patients with malignant mesothelioma, lung cancer and asbestosis. Anticancer Res. 2013;33:5517-24 pubmed
    ..In the diagnosis of malignant mesothelioma (MM) there still is a lack of specific and sensitive screening biomarkers: this study examined the discriminatory power of a panel of serum/plasma biomarkers...
  27. Rihova Z, Maixnerova D, Jancova E, Pelclova D, Bartunkova J, Fenclova Z, et al. Silica and asbestos exposure in ANCA-associated vasculitis with pulmonary involvement. Ren Fail. 2005;27:605-8 pubmed
    ..6% of the patients (12.9% to SiO2, 9.7% to asbestos), compared with 0% of control subjects (p<0.05). Our findings support the pathophysiologic role of silica in AAV. ..
  28. KLIMENT C, Tobolewski J, Manni M, Tan R, Enghild J, Oury T. Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung. Antioxid Redox Signal. 2008;10:261-8 pubmed
    b>Asbestosis is a form of interstitial lung disease caused by the inhalation of asbestos fibers, leading to inflammation and pulmonary fibrosis...
  29. Tephly L, Carter A. Asbestos-induced MKP-3 expression augments TNF-alpha gene expression in human monocytes. Am J Respir Cell Mol Biol. 2008;39:113-23 pubmed publisher
    ..We found that p38 and ERK were differentially activated in alveolar macrophages obtained from patients with asbestosis compared with normal subjects...
  30. Ameille J, Brochard P, Letourneux M, Paris C, Pairon J. Asbestos-related cancer risk in patients with asbestosis or pleural plaques. Rev Mal Respir. 2011;28:e11-7 pubmed publisher
    The relationships between benign asbestos-related diseases (asbestosis and pleural plaques) and thoracic cancers are still debated. The aim of this paper was to review the epidemiological data relevant to this issue.
  31. Miserocchi G, Sancini G, Mantegazza F, Chiappino G. Translocation pathways for inhaled asbestos fibers. Environ Health. 2008;7:4 pubmed publisher
  32. Murlidhar V, Kanhere V. Asbestosis in an asbestos composite mill at Mumbai: a prevalence study. Environ Health. 2005;4:24 pubmed
    ..lack of training for doctors in diagnosis of occupational lung diseases, deliberate misdiagnosis by doctors of asbestosis as either chronic bronchitis or tuberculosis and the inherent class bias of middle class doctors against workers...
  33. Bitchatchi E, Kayser K, Perelman M, Richter E. Mesothelioma and asbestosis in a young woman following occupational asbestos exposure: Short latency and long survival: Case Report. Diagn Pathol. 2010;5:81 pubmed publisher
    ..lung biopsy, which demonstrated asbestos bodies and microscopic interstitial fibrosis -conforming evidence for asbestosis. The patient is alive and well 12 years after diagnosis and 14 years after onset of symptoms...
  34. Alfonso H, Fritschi L, de Klerk N, Ambrosini G, Beilby J, Olsen N, et al. Plasma concentrations of retinol, carotene, and vitamin E and mortality in subjects with asbestosis in a cohort exposed to crocidolite in Wittenoom, Western Australia. J Occup Environ Med. 2005;47:573-9 pubmed
    We sought to examine the relationships between plasma concentrations of retinol, carotene, and vitamin E and mortality associated with asbestosis in people previously exposed to crocidolite.
  35. Azari M, Nasermoaddeli A, Movahadi M, Mehrabi Y, Hatami H, Soori H, et al. Risk assessment of lung cancer and asbestosis in workers exposed to asbestos fibers in brake shoe factory in Iran. Ind Health. 2010;48:38-42 pubmed
    ..fiber, imported from Russia, is used mainly for manufacturing purposes in Iran and related risks in the form of asbestosis and cancer were studied...
  36. Williams P, Phelka A, Paustenbach D. A review of historical exposures to asbestos among skilled craftsmen (1940-2006). J Toxicol Environ Health B Crit Rev. 2007;10:319-77 pubmed
  37. Li Y, Karjalainen A, Koskinen H, Vainio H, Pukkala E, Hemminki K, et al. Serum growth factors in asbestosis patients. Biomarkers. 2009;14:61-6 pubmed publisher
    ..were determined by enzyme-linked immunosorbent assays in the banked serum samples of a cohort of workers with asbestosis, and the relationships of the growth factor levels to the subsequent development of cancer and to the ..
  38. Gamble J, Gibbs G. An evaluation of the risks of lung cancer and mesothelioma from exposure to amphibole cleavage fragments. Regul Toxicol Pharmacol. 2008;52:S154-86 pubmed publisher
    ..In sum, the weight of evidence fully supports a conclusion that non-asbestiform amphiboles do not increase the risk of lung cancer or mesothelioma...
  39. Donovan E, Donovan B, McKinley M, Cowan D, Paustenbach D. Evaluation of take home (para-occupational) exposure to asbestos and disease: a review of the literature. Crit Rev Toxicol. 2012;42:703-31 pubmed publisher
  40. Antao V, Pinheiro G, Wassell J. Asbestosis mortality in the USA: facts and predictions. Occup Environ Med. 2009;66:335-8 pubmed publisher
    Mortality trends in the USA show that deaths from asbestosis are increasing, while deaths related to other pneumoconiosis are declining. To analyse the association between asbestos consumption and asbestosis mortality trends...
  41. Franko A, Dodic Fikfak M, Arneric N, Dolzan V. Glutathione S-transferases GSTM1 and GSTT1 polymorphisms and asbestosis. J Occup Environ Med. 2007;49:667-71 pubmed
    ..polymorphism of glutathione S-transferases GSTM1 and GSTT1 represents a risk factor for the development of asbestosis. In total, 262 cases with asbestosis and 265 controls, selected from a cohort of 2080 workers occupationally ..
  42. Panduri V, Surapureddi S, Soberanes S, Weitzman S, Chandel N, Kamp D. P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis. Am J Respir Cell Mol Biol. 2006;34:443-52 pubmed
    ..This suggests an important interactive effect between p53 and the mitochondria in the pathogenesis of asbestos-induced pulmonary toxicity that may have broader implications for our understanding of pulmonary fibrosis and lung cancer...
  43. Loomis D, Dement J, Wolf S, Richardson D. Lung cancer mortality and fibre exposures among North Carolina asbestos textile workers. Occup Environ Med. 2009;66:535-42 pubmed publisher
    ..To describe mortality among workers exposed to chrysotile asbestos and evaluate the relationship between lung cancer and asbestos fibre exposure...
  44. Tooker B, Newman L, Bowler R, Karjalainen A, Oksa P, Vainio H, et al. Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers. Biomarkers. 2011;16:181-91 pubmed publisher
    To identify biomarkers for cancer in asbestosis patients. SELDI-TOF and CART were used to identify serum biomarker profiles in 35 asbestosis patients who subsequently developed cancer and 35 did not develop cancer...
  45. Horska A, Kazimirova A, Barancoková M, Wsolova L, Tulinska J, Dusinska M. Genetic predisposition and health effect of occupational exposure to asbestos. Neuro Endocrinol Lett. 2006;27 Suppl 2:100-3 pubmed
    ..003). Clinical examination showed that 44.3% of exposed workers developed symptoms of asbestosis. We were interested in the relationship between the risk of asbestos-coupled diseases and individual variability ..
  46. Miura Y, Nishimura Y, Katsuyama H, Maeda M, Hayashi H, Dong M, et al. Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells. Apoptosis. 2006;11:1825-35 pubmed
    To analyze the possibility that immunological alteration in asbestos-related diseases (ARDs) such as asbestosis (ASB) and malignant mesothelioma (MM) may affect the progression of cancers, a human adult T cell leukemia virus-immortalized ..
  47. Roggli V, Gibbs A, Attanoos R, Churg A, Popper H, Cagle P, et al. Pathology of asbestosis- An update of the diagnostic criteria: Report of the asbestosis committee of the college of american pathologists and pulmonary pathology society. Arch Pathol Lab Med. 2010;134:462-80 pubmed publisher
    b>Asbestosis is defined as diffuse pulmonary fibrosis caused by the inhalation of excessive amounts of asbestos fibers...
  48. Maeda M, Nishimura Y, Hayashi H, Kumagai N, Chen Y, Murakami S, et al. Decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients. Am J Respir Cell Mol Biol. 2011;45:795-803 pubmed publisher
    ..These findings show reduction of antitumor immune function in asbestos-exposed patients and indicate that CXCR3, IFN-?, and CXCL10/IP10 may be candidates to detect and monitor disease status. ..
  49. Yin Q, Brody A, Sullivan D. Laser capture microdissection reveals dose-response of gene expression in situ consequent to asbestos exposure. Int J Exp Pathol. 2007;88:415-25 pubmed
    ..To our knowledge, this is the first demonstration of a dose-response to a toxic particle in situ, and this response appears to be dependent on the number of fibres that deposits at the individual anatomic site. ..
  50. Poland C, Duffin R, Kinloch I, Maynard A, Wallace W, Seaton A, et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol. 2008;3:423-8 pubmed publisher
    ..Our results suggest the need for further research and great caution before introducing such products into the market if long-term harm is to be avoided...
  51. Horton K, Kapil V, Larson T, Muravov O, Melnikova N, Anderson B. A review of the federal government's health activities in response to asbestos-contaminated ore found in Libby, Montana. Inhal Toxicol. 2006;18:925-40 pubmed
    ..Prolonged exposure to asbestos can cause serious and life-threatening health conditions, including asbestosis, lung cancer, and mesothelioma...
  52. Sullivan P. Vermiculite, respiratory disease, and asbestos exposure in Libby, Montana: update of a cohort mortality study. Environ Health Perspect. 2007;115:579-85 pubmed
    ..Asbestos-contaminated Libby vermiculite was used in loose-fill attic insulation that remains in millions of homes in the United States, Canada, and other countries...
  53. Franko A, Dolzan V, Arneric N, Dodic Fikfak M. The influence of genetic polymorphisms of GSTP1 on the development of asbestosis. J Occup Environ Med. 2008;50:7-12 pubmed publisher
    Genetic factors play an important role in the development of asbestosis. The aim of this study was to investigate whether genetic polymorphisms of glutathione S-transferase (GST) P1 represent a risk factor for this disease...