vocal cords

Summary

Summary: A pair of cone-shaped elastic mucous membrane projecting from the laryngeal wall and forming a narrow slit between them. Each contains a thickened free edge (vocal ligament) extending from the THYROID CARTILAGE to the ARYTENOID CARTILAGE, and a VOCAL MUSCLE that shortens or relaxes the vocal cord to control sound production.

Top Publications

  1. Echternach M, Dollinger M, Sundberg J, Traser L, Richter B. Vocal fold vibrations at high soprano fundamental frequencies. J Acoust Soc Am. 2013;133:EL82-7 pubmed publisher
    ..Therefore, the recent results suggest that human voice production at very high F0s up to 1568 Hz is not caused by turbulence, but rather by airflow modulation from vocal fold oscillations...
  2. Reiter R, Rudolf R, Brosch S, Sibylle B. Laryngoplasty with hyaluronic acid in patients with unilateral vocal fold paralysis. J Voice. 2012;26:785-91 pubmed publisher
    ..Analysis of the optimal glottic width, effectiveness (long-term voice improvement as a consequence of longevity of Restylane), and safety of this new method was made...
  3. Rohde M, Grøntved A, Krogdahl A, Godballe C. Aggressive elimination of precancerous lesions of the vocal cords to avoid risk of cancer. Dan Med J. 2012;59:A4399 pubmed
    Several studies show that early histological classification and excision of precancerous lesions of the vocal cords reduces the risk of cancer development. National Danish guidelines have not been established...
  4. Szkiełkowska A, Miaśkiewicz B, Krasnodębska P, Uszyńska Tuzinek M, Skarzynski H. [The videostrobokymography in phoniatric practice]. Otolaryngol Pol. 2012;66:214-8 pubmed publisher
    ..Thanks to videostrobokymography the vocal fold vibration from particular area of glottal chink, can be assessed in an objective way...
  5. Titze I. Nonlinear source-filter coupling in phonation: theory. J Acoust Soc Am. 2008;123:2733-49 pubmed publisher
    ..In addition, the linear theory does not predict bifurcations in the dynamical behavior of vocal fold vibration due to acoustic loading by the vocal tract. ..
  6. Yamashita M, Bless D, Welham N. Morphological and extracellular matrix changes following vocal fold injury in mice. Cells Tissues Organs. 2010;192:262-71 pubmed publisher
    ..Morphological and ECM changes following vocal fold injury in the mouse were generally consistent with those reported in other animal models, particularly the rat, although wound repair in the mouse appears to occur at a faster rate. ..
  7. Hirano S. Current treatment of vocal fold scarring. Curr Opin Otolaryngol Head Neck Surg. 2005;13:143-7 pubmed
    ..However, no clinical trials have been performed, and more studies are necessary to establish the optimum modality. ..
  8. Awd Allah R, Dkhil M, Farhoud E. Fibroblasts in the human vocal fold mucosa: an ultrastructural study of different age groups. Singapore Med J. 2009;50:201-7 pubmed
    ..Furthermore, geriatric changes in the vocal ligament can be attributed to the activities and the presence of ageing processes in fibroblasts of geriatric VF mucosa. ..
  9. Thibeault S, Li W, Bartley S. A method for identification of vocal fold lamina propria fibroblasts in culture. Otolaryngol Head Neck Surg. 2008;139:816-22 pubmed publisher
    ..This simple rule-out methodology for fibroblast confirmation is an important step when establishing cell culture, and it establishes sound internal validity particularly in the early stages of this emerging area of study. ..

More Information

Publications89

  1. Wurzbacher T, Schwarz R, Dollinger M, Hoppe U, Eysholdt U, Lohscheller J. Model-based classification of nonstationary vocal fold vibrations. J Acoust Soc Am. 2006;120:1012-27 pubmed
    ..The nonstationary vocal fold vibrations contain additional information about vocal fold irregularities, which are needed for an objective interpretation and classification of voice disorders. ..
  2. Cook D, Mongeau L. Sensitivity of a continuum vocal fold model to geometric parameters, constraints, and boundary conditions. J Acoust Soc Am. 2007;121:2247-53 pubmed
    ..The overestimation of each modal frequency was proportional to the ratio of longitudinal to transverse Young's modulus, and was significant for ratio values less than 20. ..
  3. Speyer R. Effects of voice therapy: a systematic review. J Voice. 2008;22:565-80 pubmed
    ..Furthermore, the conclusions of most studies cannot be generalized easily or compared to one another. As a consequence, many issues in the field of effects of voice therapy have yet been unanswered. ..
  4. Vokes D, Jackson R, Guo S, Perez J, Su J, Ridgway J, et al. Optical coherence tomography-enhanced microlaryngoscopy: preliminary report of a noncontact optical coherence tomography system integrated with a surgical microscope. Ann Otol Rhinol Laryngol. 2008;117:538-47 pubmed
    ..This aim of this study was to develop and evaluate a novel OCT system integrated with a surgical microscope to allow hands-free OCT imaging of the VFs, which could be performed simultaneously with microscopic visualization...
  5. Hansen J, Thibeault S. Current understanding and review of the literature: vocal fold scarring. J Voice. 2006;20:110-20 pubmed
    ..We present an up-to-date, thorough, and scholarly review of the literature in vocal fold scarring since 1996. ..
  6. Zhang Z. Influence of flow separation location on phonation onset. J Acoust Soc Am. 2008;124:1689-94 pubmed publisher
    ..However, in contrast to previous theoretical analyses, this study showed that phonation was facilitated, rather than prohibited, by the upstream movement of the flow separation point within a divergent glottis. ..
  7. Chen X, Thibeault S. Novel isolation and biochemical characterization of immortalized fibroblasts for tissue engineering vocal fold lamina propria. Tissue Eng Part C Methods. 2009;15:201-12 pubmed publisher
    ..This is the first report of immortalization and biochemical characterization of hVFFs, providing a novel and invaluable tool for tissue regeneration applications in the larynx. ..
  8. Martins R, Santana M, Tavares E. Vocal cysts: clinical, endoscopic, and surgical aspects. J Voice. 2011;25:107-10 pubmed publisher
    ..A careful examination of the vocal folds is necessary during surgery, because other laryngeal lesions may be associated with vocal cysts. ..
  9. Riede T, Titze I. Vocal fold elasticity of the Rocky Mountain elk (Cervus elaphus nelsoni) - producing high fundamental frequency vocalization with a very long vocal fold. J Exp Biol. 2008;211:2144-54 pubmed publisher
    ..The relationships between an individual's average fundamental frequency, vocal fold length and body size are discussed. ..
  10. Arviso L, Johns M, Mathison C, Klein A. Long-term outcomes of injection laryngoplasty in patients with potentially recoverable vocal fold paralysis. Laryngoscope. 2010;120:2237-40 pubmed publisher
    ..The majority of subjects with potentially recoverable UVFP recover vocal fold motion and/or adequate voice after IL without permanent intervention. ..
  11. Marina M, Marie J, Birchall M. Laryngeal reinnervation for bilateral vocal fold paralysis. Curr Opin Otolaryngol Head Neck Surg. 2011;19:434-8 pubmed publisher
    ..On the other hand, the procedure is not simple. This review explores the recent literature on surgical technique and factors that may contribute to the success...
  12. Welham N, Lim X, Tateya I, Bless D. Inflammatory factor profiles one hour following vocal fold injury. Ann Otol Rhinol Laryngol. 2008;117:145-52 pubmed
    ..Inflammatory factor and ECM gene expression changes occur in vocal fold wound sites as early as 1 hour after injury. These results should inform future efforts to attenuate vocal fold scarring via the modulation of inflammatory factors. ..
  13. Branski R, Rosen C, Verdolini K, Hebda P. Acute vocal fold wound healing in a rabbit model. Ann Otol Rhinol Laryngol. 2005;114:19-24 pubmed
    ..Manipulation and/or alteration of naturally occurring neo-matrix deposition and organization may yield improved biophysical function of the injured vocal fold. ..
  14. Merati A, Shemirani N, Smith T, Toohill R. Changing trends in the nature of vocal fold motion impairment. Am J Otolaryngol. 2006;27:106-8 pubmed
    ..Anterior cervical spine surgery surpassed thyroidectomy and all other procedures as the most common cause of iatrogenic VFMI in this contemporary study. ..
  15. Hahn M, Teply B, Stevens M, Zeitels S, Langer R. Collagen composite hydrogels for vocal fold lamina propria restoration. Biomaterials. 2006;27:1104-9 pubmed
    ..Collagen-alginate hydrogels appear to be promising materials for VF restoration, warranting further investigation. ..
  16. Cook D, Nauman E, Mongeau L. Ranking vocal fold model parameters by their influence on modal frequencies. J Acoust Soc Am. 2009;126:2002-10 pubmed publisher
    ..The results from all three methods consistently suggest that a set of five parameters are most influential in determining the vibratory characteristics of the vocal folds. ..
  17. Sivasankar M, Erickson E, Rosenblatt M, Branski R. Hypertonic challenge to porcine vocal folds: effects on epithelial barrier function. Otolaryngol Head Neck Surg. 2010;142:79-84 pubmed publisher
    ..We examined the effects of hypertonic surface fluid on vocal fold epithelial resistance, paracellular pathway morphology, and tight junction protein integrity...
  18. Zhuang P, Sprecher A, Hoffman M, Zhang Y, Fourakis M, Jiang J, et al. Phonation threshold flow measurements in normal and pathological phonation. Laryngoscope. 2009;119:811-5 pubmed publisher
    ..Future research could focus on measuring PTF in other pathologies, such as paralysis or scarring, which would also affect the effort required to produce voice. ..
  19. Chan R, Titze I. Dependence of phonation threshold pressure on vocal tract acoustics and vocal fold tissue mechanics. J Acoust Soc Am. 2006;119:2351-62 pubmed
  20. Milovanović J, Djukić V, Milovanović A, Trivić A, Baljosević I, Vukasinović M, et al. [Functional results of treatment of early carcinoma in the glottic region of the larynx]. Acta Chir Iugosl. 2009;56:95-100 pubmed
    ..From a functional point of view these two methods are superior to open surgery chordectomy. ..
  21. Chen X, Thibeault S. Role of tumor necrosis factor-alpha in wound repair in human vocal fold fibroblasts. Laryngoscope. 2010;120:1819-25 pubmed publisher
    ..Carbylan-GSX has potential as a new therapeutic approach that may lead to better treatment of vocal fold wound healing. ..
  22. Inwald E, Dollinger M, Schuster M, Eysholdt U, Bohr C. Multiparametric analysis of vocal fold vibrations in healthy and disordered voices in high-speed imaging. J Voice. 2011;25:576-90 pubmed publisher
    ..However, further research is needed to broaden our understanding of the variability within and across healthy and pathologic vocal fold vibrations for diagnosing voice disorders and therapy control. ..
  23. Luo Y, Kobler J, Zeitels S, Langer R. Effects of growth factors on extracellular matrix production by vocal fold fibroblasts in 3-dimensional culture. Tissue Eng. 2006;12:3365-74 pubmed
    ..The results also suggest that multiple growth factors might be employed sequentially or in combination to program the makeup of cell-hydrogel constructs for vocal fold tissue repair...
  24. Burns J, Kim K, Kobler J, deBoer J, Lopez Guerra G, Zeitels S. Real-time tracking of vocal fold injections with optical coherence tomography. Laryngoscope. 2009;119:2182-6 pubmed publisher
    ..Using OCT both to delineate the depth of subepithelial injections real-time and to serially image the implant over time would be valuable, and has not been demonstrated previously...
  25. Ohno T, Yoo M, Swanson E, Hirano S, Ossoff R, Rousseau B. Regeneration of aged rat vocal folds using hepatocyte growth factor therapy. Laryngoscope. 2009;119:1424-30 pubmed publisher
  26. Titze I, Hunter E. A two-dimensional biomechanical model of vocal fold posturing. J Acoust Soc Am. 2007;121:2254-60 pubmed
    ..A repeated adductory-abductory gesture in the form /hi-hi-hi-hi-hi/ is modeled with electromyographic inputs. Movement and acoustic outputs are compared between simulation and measurement...
  27. Lohscheller J, Eysholdt U, Toy H, Dollinger M. Phonovibrography: mapping high-speed movies of vocal fold vibrations into 2-D diagrams for visualizing and analyzing the underlying laryngeal dynamics. IEEE Trans Med Imaging. 2008;27:300-9 pubmed publisher
    ..The objective and precise quantification of the PVG geometry may have the potential to realize a novel classification of vocal fold vibrations...
  28. Klemuk S, Jaiswal S, Titze I. Cell viability viscoelastic measurement in a rheometer used to stress and engineer tissues at low sonic frequencies. J Acoust Soc Am. 2008;124:2330-9 pubmed publisher
    ..Resulting strain was quantified throughout the test period. Rheologic data and cell viability are reported for each condition, and future improvements are discussed...
  29. Ohno T, Hirano S, Rousseau B. Gene expression of transforming growth factor-beta1 and hepatocyte growth factor during wound healing of injured rat vocal fold. Laryngoscope. 2009;119:806-10 pubmed publisher
  30. Branski R, Barbieri S, Weksler B, Saltman B, Krishna P, Kraus D, et al. Effects of transforming growth factor-beta1 on human vocal fold fibroblasts. Ann Otol Rhinol Laryngol. 2009;118:218-26 pubmed
    ..We studied the effect of transforming growth factor (TGF)-beta on immortalized human vocal fold fibroblasts...
  31. Hahn M, Jao C, Faquin W, Grande Allen K. Glycosaminoglycan composition of the vocal fold lamina propria in relation to function. Ann Otol Rhinol Laryngol. 2008;117:371-81 pubmed
    ..This study was designed to quantify the specific glycosaminoglycans (GAGs) in the midmembranous vocal fold (VF) lamina propria (LP) and to interpret their presence in relation to the known stresses borne by each LP layer...
  32. Hamamoto T, Takumida M, Hirakawa K, Takeno S, Tatsukawa T. Localization of transient receptor potential channel vanilloid subfamilies in the mouse larynx. Acta Otolaryngol. 2008;128:685-93 pubmed publisher
  33. Doellinger M, Berry D, Berke G. A quantitative study of the medial surface dynamics of an in vivo canine vocal fold during phonation. Laryngoscope. 2005;115:1646-54 pubmed
    ..Although the medial surface dynamics have a profound influence on voice production, such data are rare because of the inaccessibility of the vocal folds...
  34. Zhou H, Felsen D, Sandulache V, Amin M, Kraus D, Branski R. Prostaglandin (PG)E2 exhibits antifibrotic activity in vocal fold fibroblasts. Laryngoscope. 2011;121:1261-5 pubmed publisher
    ..In addition, we describe a novel organotypic model, a critical step in the development of therapeutic trials...
  35. Lim J, Choi J, Kim K, Choi H. Voice analysis of patients with diverse types of Reinke's edema and clinical use of electroglottographic measurements. Acta Otolaryngol. 2006;126:62-9 pubmed
    ..Reinke's edema shows a variety of clinical patterns and differences in voice analysis depending on its type. Electroglottographic measurements help to objectively assess the severity of edema and voice quality before and after surgery...
  36. Guo S, Hutchison R, Jackson R, Kohli A, Sharp T, Orwin E, et al. Office-based optical coherence tomographic imaging of human vocal cords. J Biomed Opt. 2006;11:30501 pubmed
    ..Office-based OCT has the potential to guide surgical biopsies, direct therapy, and monitor disease. This is a promising imaging modality to study the larynx...
  37. Miller D, Schutte H. 'Mixing' the registers: glottal source or vocal tract?. Folia Phoniatr Logop. 2005;57:278-91 pubmed
    ..The results suggest that the skillful tuning of the resonances of the vocal tract contributes more toward the pedagogical goal of smoothing the register transition than does a presumed mixing of the registers at the glottal source...
  38. Riede T. Elasticity and stress relaxation of rhesus monkey (Macaca mulatta) vocal folds. J Exp Biol. 2010;213:2924-32 pubmed publisher
    ..A differentiated recruitment of tissue into oscillation could extend the frequency range specifically at the upper end of the frequency scale...
  39. Lim X, Bless D, Munoz del Rio A, Welham N. Changes in cytokine signaling and extracellular matrix production induced by inflammatory factors in cultured vocal fold fibroblasts. Ann Otol Rhinol Laryngol. 2008;117:227-38 pubmed
    ..To evaluate previously established in vivo cytokine and ECM gene expression hypotheses, we examined in vitro vocal fold fibroblast responses to exogenous inflammatory factor stimulation...
  40. Lodewyck D, Menco B, Fisher K. Immunolocalization of aquaporins in vocal fold epithelia. Arch Otolaryngol Head Neck Surg. 2007;133:557-63 pubmed
    ..To investigate the presence of aquaporin (AQP) water channels 1, 2, and 3 in stratified squamous vocal fold epithelium...
  41. Cantarella G, Mazzola R, Domenichini E, Arnone F, Maraschi B. Vocal fold augmentation by autologous fat injection with lipostructure procedure. Otolaryngol Head Neck Surg. 2005;132:239-43 pubmed
    ..Fat is theoretically the ideal implant for vocal fold augmentation because it is soft, easily available and biocompatible. However, reabsorption is a frequent cause of long-term failure...
  42. Perazzo P, Duprat A, Lancellotti C. Histological behavior of the vocal fold after hyaluronic acid injection. J Voice. 2009;23:95-8 pubmed publisher
    ..Tissue necrosis and foreign body inflammatory reaction were not observed in either group. The current study suggests that HA is a good alternative for a filling material of the vocal folds when treating glottal insufficiency...
  43. Lee W, Milstein C, Hicks D, Akst L, Esclamado R. Results of ansa to recurrent laryngeal nerve reinnervation. Otolaryngol Head Neck Surg. 2007;136:450-4 pubmed
    ..We sought to describe the results of ansa cervicalis to recurrent laryngeal nerve (ansa-RLN) reinnervation for unilateral vocal fold paralysis...
  44. Sivasankar M, Fisher K. Vocal folds detect ionic perturbations on the luminal surface: an in vitro investigation. J Voice. 2008;22:408-19 pubmed
    ..05). Viable ovine vocal fold epithelia detect ionic perturbations to the luminal surface. This sensitivity to luminal ionic challenge may be necessary to maintain the homeostasis of surface fluid...
  45. Hottinger D, Tao C, Jiang J. Comparing phonation threshold flow and pressure by abducting excised larynges. Laryngoscope. 2007;117:1695-9 pubmed
    ..Goals were to examine phonation threshold flow as a measurable parameter sensitive to physiologic changes in the vocal folds and compare the relative sensitivities of phonation threshold flow and phonation threshold pressure...
  46. Kimura M, Nito T, Sakakibara K, Tayama N, Niimi S. Clinical experience with collagen injection of the vocal fold: a study of 155 patients. Auris Nasus Larynx. 2008;35:67-75 pubmed
    ..This study evaluated the results of laryngeal collagen injection...
  47. Abdelkafy W, Smith J, Henriquez O, Golub J, Xu J, Rojas M, et al. Age-related changes in the murine larynx: initial validation of a mouse model. Ann Otol Rhinol Laryngol. 2007;116:618-22 pubmed
    ..With changing age demographics in our society and increasing emphasis on quality of life, treatment of presbylaryngis is becoming more paramount...
  48. Burns J, Zeitels S, Anderson R, Kobler J, Pierce M, de Boer J. Imaging the mucosa of the human vocal fold with optical coherence tomography. Ann Otol Rhinol Laryngol. 2005;114:671-6 pubmed
    ..Optical coherence tomography (OCT), a noncontact, noninvasive technology that provides cross-sectional images by means of backscattered light, offers the potential for delineating these layers in vivo...
  49. Dedecjus M, Adamczewski Z, Brzezinski J, Lewinski A. Real-time, high-resolution ultrasonography of the vocal folds--a prospective pilot study in patients before and after thyroidectomy. Langenbecks Arch Surg. 2010;395:859-64 pubmed publisher
    ..The aim of the study was to evaluate the functionality of vocal folds (VF) by real-time, high-resolution ultrasonography (US) and to correlate the imaged features to results of laryngological examination (LE)...
  50. Misiolek M, Ziora D, Namyslowski G, Misiolek H, Kucia J, Scierski W, et al. Long-term results in patients after combined laser total arytenoidectomy with posterior cordectomy for bilateral vocal cord paralysis. Eur Arch Otorhinolaryngol. 2007;264:895-900 pubmed
    ..In general, it can be concluded that laser arytenoidectomy with posterior cordectomy is a durable and effective procedure, although the objective assessment does not fully match the patient's subjective impression...
  51. Tokuda I, Horácek J, Svec J, Herzel H. Comparison of biomechanical modeling of register transitions and voice instabilities with excised larynx experiments. J Acoust Soc Am. 2007;122:519-31 pubmed
    ..It is concluded that the abrupt changes between chest and falsetto registers can be understood as shifts in dominance of eigenmodes of the vocal folds...
  52. Welham N, Montequin D, Tateya I, Tateya T, Choi S, Bless D. A rat excised larynx model of vocal fold scar. J Speech Lang Hear Res. 2009;52:1008-20 pubmed publisher
    ..To develop and evaluate a rat excised larynx model for the measurement of acoustic, aerodynamic, and vocal fold vibratory changes resulting from vocal fold scar...
  53. Yan Y, Damrose E, Bless D. Functional analysis of voice using simultaneous high-speed imaging and acoustic recordings. J Voice. 2007;21:604-16 pubmed
    ..The results of these analyses show that a combined imaging/acoustic analysis approach provides better characterization of the vibratory behavior of the vocal folds as it correlates with vocal output and pathology...
  54. Masaki T, Katada C, Nakayama M, Takeda M, Miyamoto S, Seino Y, et al. Narrow band imaging in the diagnosis of intra-epithelial and invasive laryngeal squamous cell carcinoma: a preliminary report of two cases. Auris Nasus Larynx. 2009;36:712-6 pubmed publisher
    ..Based on our results, the vascular neoplastic changes of carcinoma in situ of the larynx could be similar to carcinoma in situ of the esophagus...
  55. Hahn M, Kobler J, Zeitels S, Langer R. Midmembranous vocal fold lamina propria proteoglycans across selected species. Ann Otol Rhinol Laryngol. 2005;114:451-62 pubmed
    ..We examined the proteoglycan (PG) and associated sulfated glycosaminoglycan (GAG) content of the midmembranous vocal fold lamina propria (LP) of humans, dogs, pigs, and ferrets...
  56. Thibeault S. Advances in our understanding of the Reinke space. Curr Opin Otolaryngol Head Neck Surg. 2005;13:148-51 pubmed
    ..In this article, the present literature on the Reinke space in normal and disease states is reviewed including publications in the multidisciplinary fields of biomechanics, histology, molecular biology, and tissue engineering...
  57. Tateya I, Tateya T, Lim X, Sohn J, Bless D. Cell production in injured vocal folds: a rat study. Ann Otol Rhinol Laryngol. 2006;115:135-43 pubmed
    ..To reveal the characteristics of vocal fold cell production, we investigated cell proliferation in the acute phase of wound healing...
  58. Hirano S, Minamiguchi S, Yamashita M, Ohno T, Kanemaru S, Kitamura M. Histologic characterization of human scarred vocal folds. J Voice. 2009;23:399-407 pubmed publisher
    ..Deposition of elastin, HA, and fibronectin varied regardless of depth of injury. Histology of scarred vocal folds may vary with degree of injury and individual healing mechanism...
  59. Rosen C, Gartner Schmidt J, Casiano R, Anderson T, Johnson F, Remacle M, et al. Vocal fold augmentation with calcium hydroxylapatite: twelve-month report. Laryngoscope. 2009;119:1033-41 pubmed publisher
    ..To evaluate the long-term effectiveness of calcium hydroxylapatite (CaHA) vocal fold injection for patients with glottal insufficiency...
  60. Deguchi S, Hyakutake T. Theoretical consideration of the flow behavior in oscillating vocal fold. J Biomech. 2009;42:824-9 pubmed publisher
    ..These explicit descriptions containing flow-related variables are useful for understanding of the glottal aerodynamics particularly at high frequency range of the falsetto voice register...
  61. Manola M, Moscillo L, Costa G, Barillari U, Lo Sito S, Mastella A, et al. Conservative laser microsurgery for T1 glottic carcinoma. Auris Nasus Larynx. 2008;35:141-7 pubmed
    ..We also studied surgical margins and the involvement of anterior commissure...
  62. Chan R, Fu M, Young L, Tirunagari N. Relative contributions of collagen and elastin to elasticity of the vocal fold under tension. Ann Biomed Eng. 2007;35:1471-83 pubmed
    ..The data may provide guidance for surgical reconstruction and tissue engineering of different lamina propria layers...
  63. Riede T, Lingle S, Hunter E, Titze I. Cervids with different vocal behavior demonstrate different viscoelastic properties of their vocal folds. J Morphol. 2010;271:1-11 pubmed publisher
    ..The results of this study support the hypothesis that viscoelastic properties of vocal folds varies with function and vocal behavior...
  64. Berry D, Reininger H, Alipour F, Bless D, Ford C. Influence of vocal fold scarring on phonation: predictions from a finite element model. Ann Otol Rhinol Laryngol. 2005;114:847-52 pubmed
    ..In particular, phonatory variables such as fundamental frequency, oral acoustic intensity, and phonation threshold pressure (PTP) were investigated as a function of the size and position of the laryngeal scar...
  65. Piazza C, Cocco D, De Benedetto L, Del Bon F, Nicolai P, Peretti G. Narrow band imaging and high definition television in the assessment of laryngeal cancer: a prospective study on 279 patients. Eur Arch Otorhinolaryngol. 2010;267:409-14 pubmed publisher
    ..NBI has also a role in the postoperative setting, due to its ability in early detection of persistences, recurrences, and metachronous tumors...
  66. Tao C, Jiang J, Zhang Y. Simulation of vocal fold impact pressures with a self-oscillating finite-element model. J Acoust Soc Am. 2006;119:3987-94 pubmed
    ..The match between our numerical simulations and clinical observations suggests that this self-oscillating finite-element model might be valuable for predicting mechanical trauma of the vocal folds...
  67. Klemuk S, Lu X, Hoffman H, Titze I. Phonation threshold pressure predictions using viscoelastic properties up to 1,400 Hz of injectables intended for Reinke's space. Laryngoscope. 2010;120:995-1001 pubmed publisher
  68. Tsai C, Chen J, Shau Y, Hsiao T. Dynamic B-mode ultrasound imaging of vocal fold vibration during phonation. Ultrasound Med Biol. 2009;35:1812-8 pubmed publisher
    ..This is, to the best of our knowledge, the first time that vocal fold vibration physiology has been studied using B-mode imaging and Echo-PIV...
  69. Kobler J, Chang E, Zeitels S, Yun S. Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography. Laryngoscope. 2010;120:1354-62 pubmed publisher
    ..If feasible, this approach could be a useful research tool and spur development of new clinical instrumentation...
  70. Remacle M, Lawson G. Results with collagen injection into the vocal folds for medialization. Curr Opin Otolaryngol Head Neck Surg. 2007;15:148-52 pubmed
    ..This review outlines the indications, surgical techniques and follow-up, with results, for current collagen use...
  71. Alipour F, Jaiswal S, Vigmostad S. Vocal fold elasticity in the pig, sheep, and cow larynges. J Voice. 2011;25:130-6 pubmed publisher
    ..The current study provides quantitative data for the elastic properties of the oscillating laryngeal tissue in these species and indicates that nonlinear behavior of these tissues may lead to wider oscillation ranges...
  72. Hahn M, Kobler J, Zeitels S, Langer R. Quantitative and comparative studies of the vocal fold extracellular matrix II: collagen. Ann Otol Rhinol Laryngol. 2006;115:225-32 pubmed
    ..This study examines the collagen content and turnover in the midmembranous vocal fold laminae propriae (LPs) of humans, dogs, pigs, and ferrets...
  73. Sivasankar M, Fisher K. Vocal fold epithelial response to luminal osmotic perturbation. J Speech Lang Hear Res. 2007;50:886-98 pubmed
    ..Bidirectional transepithelial water fluxes were measured in vocal folds exposed to physiologically realistic luminal osmotic perturbations in vitro...
  74. Thibeault S, Klemuk S, Smith M, Leugers C, Prestwich G. In vivo comparison of biomimetic approaches for tissue regeneration of the scarred vocal fold. Tissue Eng Part A. 2009;15:1481-7 pubmed publisher
    ..Optimization of cell-scaffold interactions and subsequent cell behavior is necessary for utilization of scaffold and scaffold-cell approaches...
  75. Tateya T, Tateya I, Munoz del Rio A, Bless D. Postnatal development of rat vocal folds. Ann Otol Rhinol Laryngol. 2006;115:215-24 pubmed
    ..In this study we aimed to determine the feasibility of using a rat model for the study of postnatal vocal fold (VF) development...
  76. Tateya T, Tateya I, Sohn J, Bless D. Histological study of acute vocal fold injury in a rat model. Ann Otol Rhinol Laryngol. 2006;115:285-92 pubmed
    ..We used an acute vocal fold injury in a rat model to characterize vocal fold wound healing by studying the expression pattern of the extracellular matrix components in the vocal fold lamina propria...
  77. Jiang J, Tao C. The minimum glottal airflow to initiate vocal fold oscillation. J Acoust Soc Am. 2007;121:2873-81 pubmed
    ..Also discussed is the potential significance of PTF in investigating the energy distribution in a vocal fold vibration system and related clinical applications...
  78. Alipour F, Scherer R. On pressure-frequency relations in the excised larynx. J Acoust Soc Am. 2007;122:2296-305 pubmed
    ..9+/-0.7 Hzcm H(2)O, and for the higher mode was 5.3+/-0.5 Hzcm H(2)O for adduction changes and 8.2+/-4.4 Hzcm H(2)O for elongation changes. The results suggest that during speech and singing, the dFdP relationships are taken into account...
  79. Smith D, Patterson R. The interaction of glottal-pulse rate and vocal-tract length in judgements of speaker size, sex, and age. J Acoust Soc Am. 2005;118:3177-86 pubmed
    ..For vowels with abnormal combinations of low GPRs and short VTLs, the VTL information appears to decide the sex/age judgement...
  80. Rosen C. Stroboscopy as a research instrument: development of a perceptual evaluation tool. Laryngoscope. 2005;115:423-8 pubmed
    ..Future research using this instrument will most likely increase the reliability and utility of the instrument with the use of prestudy reviewer training and/or the use of video examples to serve as anchors or external references...