glottis

Summary

Summary: The vocal apparatus of the larynx, situated in the middle section of the larynx. Glottis consists of the VOCAL FOLDS and an opening (rima glottidis) between the folds.

Top Publications

  1. Franchin G, Minatel E, Gobitti C, Talamini R, Vaccher E, Sartor G, et al. Radiotherapy for patients with early-stage glottic carcinoma: univariate and multivariate analyses in a group of consecutive, unselected patients. Cancer. 2003;98:765-72 pubmed
    ..The impact on local control of tobacco smoking and second primary malignancies also was investigated...
  2. Furusaka T, Matuda H, Saito T, Katsura Y, Ikeda M. Long-term observations and salvage operations on patients with T2N0M0 squamous cell carcinoma of the glottic larynx treated with radiation therapy alone. Acta Otolaryngol. 2012;132:546-51 pubmed publisher
    ..Thirty-four patients underwent salvage operations and a safe margin for the partial laryngectomy was evaluated by histopathological examination of serial sections of the surgical specimen...
  3. Ansarin M, Cattaneo A, Santoro L, Massaro M, Zorzi S, Grosso E, et al. Laser surgery of early glottic cancer in elderly. Acta Otorhinolaryngol Ital. 2010;30:169 pubmed
  4. Itoh Y, Hirasawa N, Naganawa S, Ishihara S, Suzuki K, Koyama K, et al. Combined chemoradiotherapy for early glottic cancer in clinical practice in Japan: analysis of 10 institutions. Anticancer Res. 2010;30:5181-4 pubmed
    ..To conduct a retrospective analysis regarding treatment strategies for early glottic cancer (GC) at ten institutions...
  5. Higgins K. What treatment for early-stage glottic carcinoma among adult patients: CO2 endolaryngeal laser excision versus standard fractionated external beam radiation is superior in terms of cost utility?. Laryngoscope. 2011;121:116-34 pubmed publisher
    ..To determine which treatment for Tis/T1 glottic carcinoma among adult patients, transoral CO(2) laser excision (TOL) versus external beam radiation (XRT), is superior in terms of cost utility...
  6. Hirasawa N, Itoh Y, Ishihara S, Kubota S, Itoh J, Fujimoto Y, et al. Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis. Head Neck Oncol. 2010;2:20 pubmed publisher
    ..To assess the results for local control (LC) and survival in patients with early-stage glottic cancer (GC) who were treated by radiotherapy (RT) with or without chemotherapy...
  7. Mendenhall W, Werning J, Hinerman R, Amdur R, Villaret D. Management of T1-T2 glottic carcinomas. Cancer. 2004;100:1786-92 pubmed
    ..The remaining patients were optimally treated with radiotherapy. Open partial laryngectomy was reserved for patients with locally recurrent tumors. ..
  8. Gallo A, de Vincentiis M, Manciocco V, Simonelli M, Fiorella M, Shah J. CO2 laser cordectomy for early-stage glottic carcinoma: a long-term follow-up of 156 cases. Laryngoscope. 2002;112:370-4 pubmed
    ..4%. According to our experience, we can conclude that endoscopic laser surgery is an efficacious and cost-effective treatment for early stage glottic cancer. ..
  9. Ansarin M, Planicka M, Rotundo S, Santoro L, Zurlo V, Maffini F, et al. Endoscopic carbon dioxide laser surgery for glottic cancer recurrence after radiotherapy: oncological results. Arch Otolaryngol Head Neck Surg. 2007;133:1193-7 pubmed
    ..Oncological results are satisfactory, and organ preservation can be achieved in a high proportion of cases; however, the risk of laryngeal stenosis is high in women. ..

More Information

Publications86

  1. Spirydovich S, Papiez L, Moskvin V, DesRosiers P. Evaluation of underdosage in the external photon beam radiotherapy of glottic carcinoma: Monte Carlo study. Radiother Oncol. 2006;78:159-64 pubmed
    ..We conclude the significant underdosage at the air-tissue interface in the larynx occurs in traditional radiotherapy treatments, especially in the glottic part of the larynx. ..
  2. Zhang Z. Influence of flow separation location on phonation onset. J Acoust Soc Am. 2008;124:1689-94 pubmed publisher
    ..However, in contrast to previous theoretical analyses, this study showed that phonation was facilitated, rather than prohibited, by the upstream movement of the flow separation point within a divergent glottis.
  3. Steiner W, Vogt P, Ambrosch P, Kron M. Transoral carbon dioxide laser microsurgery for recurrent glottic carcinoma after radiotherapy. Head Neck. 2004;26:477-84 pubmed
    ..Compared with salvage laryngectomy, results are superior with respect to preservation of laryngeal function. Great expertise is required, especially in resections of advanced-stage recurrent carcinomas. ..
  4. Puxeddu R, Piazza C, Mensi M, Ledda G, Argiolas F, Peretti G. Carbon dioxide laser salvage surgery after radiotherapy failure in T1 and T2 glottic carcinoma. Otolaryngol Head Neck Surg. 2004;130:84-8 pubmed
  5. Frata P, Cellai E, Magrini S, Bonetti B, Vitali E, Tonoli S, et al. Radical radiotherapy for early glottic cancer: Results in a series of 1087 patients from two Italian radiation oncology centers. II. The case of T2N0 disease. Int J Radiat Oncol Biol Phys. 2005;63:1387-94 pubmed
  6. Rucci L, Romagnoli P, Scala J. CO(2) laser therapy in Tis and T1 glottic cancer: indications and results. Head Neck. 2010;32:392-8 pubmed publisher
    ..Type I to type IV cordectomy, when indicated, can achieve radical treatment of most T1 glottic cancer. Type V cordectomy requires that any suspicion of cartilage invasion, even microscopic, be excluded. ..
  7. Smith J, Johnson J, Cognetti D, Landsittel D, Gooding W, Cano E, et al. Quality of life, functional outcome, and costs of early glottic cancer. Laryngoscope. 2003;113:68-76 pubmed
    ..In addition to actual costs, the hidden costs for radiation therapy versus endoscopic excision were all greater in terms of total number of hours of work missed, total travel time, and total travel distance. ..
  8. Roedel R, Matthias C, Wolff H, Schindler P, Aydin T, Christiansen H. Transoral laser microsurgery for recurrence after primary radiotherapy of early glottic cancer. Auris Nasus Larynx. 2010;37:474-81 pubmed publisher
    ..However, in case of failure after TLM for the first recurrence, salvage laryngectomy should be considered early as local control by further laser surgery is unfavorable. ..
  9. Sims H, Heywood B. Post-transplant actinomycosis of the posterior glottis involving both vocal processes. Otolaryngol Head Neck Surg. 2007;137:967-8 pubmed
  10. Chone C, Yonehara E, Martins J, Altemani A, Crespo A. Importance of anterior commissure in recurrence of early glottic cancer after laser endoscopic resection. Arch Otolaryngol Head Neck Surg. 2007;133:882-7 pubmed
    ..Higher recurrence rates were observed in cases with compromised additional margins and in T1 cases. ..
  11. Alipour F, Finnegan E, Scherer R. Aerodynamic and acoustic effects of abrupt frequency changes in excised larynges. J Speech Lang Hear Res. 2009;52:465-81 pubmed publisher
    ..Relatively abrupt F(0) changes also occurred for gradual adduction changes, with the chest register corresponding to greater adduction, falsetto to less adduction. ..
  12. Zhang S, Hayashi R, Fujii M, Hasegawa Y, Yoshino K, Fukayama M, et al. Total microvessel perimeter per tumor area is a predictor of radiosensitivity in early-stage glottic carcinoma. Int J Radiat Oncol Biol Phys. 2009;73:1104-9 pubmed publisher
    ..High TP/TA may be a better indication for radiotherapy than for partial laryngectomy or laser excision. ..
  13. KRANE M, Barry M, Wei T. Unsteady behavior of flow in a scaled-up vocal folds model. J Acoust Soc Am. 2007;122:3659-70 pubmed publisher
    Measurements of the fluid flow through a scaled-up model of the human glottis are presented to determine whether glottal flow may be approximated as unsteady...
  14. Ansarin M, Santoro L, Cattaneo A, Massaro M, Calabrese L, Giugliano G, et al. Laser surgery for early glottic cancer: impact of margin status on local control and organ preservation. Arch Otolaryngol Head Neck Surg. 2009;135:385-90 pubmed publisher
    ..Positive margins require further treatment; close margins may require further treatment depending on tumor characteristics. ..
  15. Gowda R, Henk J, Mais K, Sykes A, Swindell R, Slevin N. Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience. Radiother Oncol. 2003;68:105-11 pubmed
    ..The short overall treatment time and large fraction size may be advantageous in radiotherapy of these well-differentiated tumours. ..
  16. Bibby J, Cotton S, Perry A, Corry J. Voice outcomes after radiotherapy treatment for early glottic cancer: assessment using multidimensional tools. Head Neck. 2008;30:600-10 pubmed
    ..In describing postradiotherapy voices in this study, pertinent measures of voice outcomes have been established, setting the benchmark for comparison in future cohort studies. ..
  17. Schindler A, Palonta F, Preti G, Ottaviani F, Schindler O, Cavalot A. Voice quality after carbon dioxide laser and conventional surgery for T1A glottic carcinoma. J Voice. 2004;18:545-50 pubmed
    ..The data on voice outcome per se do not indicate the selection of one surgical approach over another. ..
  18. Tao C, Jiang J. The phonation critical condition in rectangular glottis with wide prephonatory gaps. J Acoust Soc Am. 2008;123:1637-41 pubmed publisher
    ..The phonation threshold flow can be a useful aerodynamic parameter for pathological conditions in which the incomplete glottal gap is often seen. ..
  19. Krengli M, Policarpo M, Manfredda I, Aluffi P, Gambaro G, Panella M, et al. Voice quality after treatment for T1a glottic carcinoma--radiotherapy versus laser cordectomy. Acta Oncol. 2004;43:284-9 pubmed
    ..001). Voice assessment showed better results after radiotherapy compared with laser cordectomy. Voice outcome should be carefully considered in the treatment decision for T1 glottic carcinoma. ..
  20. Schrijvers M, van Riel E, Langendijk J, Dikkers F, Schuuring E, van der Wal J, et al. Higher laryngeal preservation rate after CO2 laser surgery compared with radiotherapy in T1a glottic laryngeal carcinoma. Head Neck. 2009;31:759-64 pubmed publisher
    ..043). Patients with T1a glottic carcinoma with normal/diminished mucosal wave treated with CO(2) laser surgery had a significantly better laryngeal preservation rate than patients treated with radiotherapy. ..
  21. Jones D, Mendenhall C, Kirwan J, Morris C, Donnan A, Holwerda S, et al. Radiation therapy for management of t1-t2 glottic cancer at a private practice. Am J Clin Oncol. 2010;33:587-90 pubmed publisher
    ..The addition of concomitant weekly cisplatin 30 mg/M² is considered for patients with T2B cancers. Open parotid laryngectomy is reserved for salvage of suitable patients with a local recurrence. ..
  22. Steffen A, Jafari C, Merz H, Galle J, Berger G. Subglottic MALT lymphoma of the larynx--more attention to the glottis. In Vivo. 2007;21:695-8 pubmed
    ..Mucosa-associated lymphoid tissue (MALT) lymphoma of the larynx is a rare but well-documented entity which may arise from chronic inflammatory process. Supraglottic left regions are predominant due to unknown reason...
  23. Kocaturk S, Han U, Yilmazer D, Onal B, Erkam U. A hystopathological study of thyroarytenoid muscle invasion in early (T1) glottic carcinoma. Otolaryngol Head Neck Surg. 2005;132:581-3 pubmed
    ..Surgical specimens belonging to 16 patients who underwent partial laryngectomy for T1 glottic cancer were subjected to detailed histopathologic examination; 11 of the patients were staged as T1a while 5 were staged as T1b...
  24. Lawson G, Jamart J, Remacle M. Improving the functional outcome of Tucker's reconstructive laryngectomy. Head Neck. 2001;23:871-8 pubmed
    ..The goal of reconstructive laryngectomy addressing glottic carcinoma, as described by Tucker, is twofold: achieve local control and preserve as much as possible the physiological laryngeal function...
  25. Wedman J, Heimdal J, Elstad I, Olofsson J. Voice results in patients with T1a glottic cancer treated by radiotherapy or endoscopic measures. Eur Arch Otorhinolaryngol. 2002;259:547-50 pubmed
    Early squamous cell carcinomas of the glottis can be treated effectively by means of surgery or external beam radiotherapy...
  26. Rödel R, Steiner W, Müller R, Kron M, Matthias C. Endoscopic laser surgery of early glottic cancer: involvement of the anterior commissure. Head Neck. 2009;31:583-92 pubmed publisher
    ..Early glottic cancer can be cured with transoral laser resection, but in cases with anterior commissure involvement, there is still controversy concerning the best treatment modality...
  27. Smee R, Meagher N, Williams J, Broadley K, Bridger G. Role of radiotherapy in early glottic carcinoma. Head Neck. 2010;32:850-9 pubmed publisher
    ..Early glottic carcinoma has a high local control prospect with radiotherapy. This review evaluates a single center's experience...
  28. Reddy S, Hong R, Nagda S, Emami B. Effect of tumor bulk on local control and survival of patients with T1 glottic cancer: a 30-year experience. Int J Radiat Oncol Biol Phys. 2007;69:1389-94 pubmed
    ..To evaluate the effect of tumor bulk on local control and survival of patients with T1 glottic cancer...
  29. Brandenburg J. Laser cordotomy versus radiotherapy: an objective cost analysis. Ann Otol Rhinol Laryngol. 2001;110:312-8 pubmed
    ..Hence, the findings of this study provide strong support for initially treating early glottic tumors with laser surgery...
  30. Haugen H, Johansson K, Mercke C. Hyperfractionated-accelerated or conventionally fractionated radiotherapy for early glottic cancer. Int J Radiat Oncol Biol Phys. 2002;52:109-19 pubmed
    ..Results for local control and survival were calculated and compared to those for T1N(0)M(0) tumors treated with a once-a-day fractionated schedule...
  31. Nomiya T, Nemoto K, Wada H, Takai Y, Yamada S. Advantage of accelerated fractionation regimens in definitive radiotherapy for stage II glottic carcinoma. Ann Otol Rhinol Laryngol. 2006;115:727-32 pubmed
    ..We evaluated the prognostic factors for local control of T2 glottic cancer and verified the efficacy of accelerated fractionation regimens such as hyperfractionation and accelerated hyperfractionation...
  32. Dutschmann M, Paton J. Trigeminal reflex regulation of the glottis depends on central glycinergic inhibition in the rat. Am J Physiol Regul Integr Comp Physiol. 2002;282:R999-R1005 pubmed
    ..Thus the integrity of glycinergic inhibition within the pontomedullary respiratory network is critical for the coordination of cranial and spinal motor outflows during eupnea but also for protective reflex regulation of the upper airway...
  33. Sidlof P, Svec J, Horácek J, Vesely J, Klepacek I, Havlík R. Geometry of human vocal folds and glottal channel for mathematical and biomechanical modeling of voice production. J Biomech. 2008;41:985-95 pubmed publisher
    ..Left-right differences between the cross-sectional shapes of the vocal folds were found in both the larynges...
  34. Sjögren E, Langeveld T, Baatenburg de Jong R. Clinical outcome of T1 glottic carcinoma since the introduction of endoscopic CO2 laser surgery as treatment option. Head Neck. 2008;30:1167-74 pubmed publisher
    ..Since the introduction of endoscopic laser surgery at our institution in 1996, 189 patients have been treated for T1 glottic carcinoma...
  35. Motta G, Esposito E, Motta S, Tartaro G, Testa D. CO2 laser surgery in the treatment of glottic cancer. Head Neck. 2005;27:733 pubmed
  36. Lee S, Park J, Kang S, Kim D, Song S. External control of exhalation for cough assistance: a method for patients with glottis dysfunction and/or tracheostomy. Arch Phys Med Rehabil. 2009;90:1402-7 pubmed publisher
    To investigate the effectiveness of our method of assisting a cough by mimicking the functions of the glottis in patients with bulbar muscle weakness or paralysis and/or those who had a tracheostomy tube.
  37. Núñez Batalla F, Caminero Cueva M, Señaris González B, Llorente Pendás J, Gorriz Gil C, López Llames A, et al. Voice quality after endoscopic laser surgery and radiotherapy for early glottic cancer: objective measurements emphasizing the Voice Handicap Index. Eur Arch Otorhinolaryngol. 2008;265:543-8 pubmed
    ..There is a reduced impact on the patient's perception of voice quality after radiotherapy, despite there being no significant differences in vocal quality between radiotherapy and laser cordectomy...
  38. Alipour F, Scherer R. On pressure-frequency relations in the excised larynx. J Acoust Soc Am. 2007;122:2296-305 pubmed
    ..9+/-0.7 Hzcm H(2)O, and for the higher mode was 5.3+/-0.5 Hzcm H(2)O for adduction changes and 8.2+/-4.4 Hzcm H(2)O for elongation changes. The results suggest that during speech and singing, the dFdP relationships are taken into account...
  39. Agarwal J, Baccher G, Waghmare C, Mallick I, Ghosh Laskar S, Budrukkar A, et al. Factors affecting the quality of voice in the early glottic cancer treated with radiotherapy. Radiother Oncol. 2009;90:177-82 pubmed publisher
    ..To prospectively analyze the objective voice quality before and after radiotherapy (RT) for early glottic cancer and to evaluate the role of different factors that may affect it...
  40. Mlynarek A, Kost K, Gesser R. Radiotherapy versus surgery for early T1-T2 glottic carcinoma. J Otolaryngol. 2006;35:413-9 pubmed
    ..To compare surgery and radiotherapy as treatments for early T1-T2 glottic cancer in terms of local and regional control, complications, cost, and voice outcome...
  41. Sasaki C, Ho S, Kim Y. Critical role of central facilitation in the glottic closure reflex. Ann Otol Rhinol Laryngol. 2001;110:401-5 pubmed
    ..A precise understanding of this effect may improve the prevention of aspiration in patients emerging from prolonged sedation or under heavy psychotropic control...
  42. O Connor C, Stix M. Bubble solution diagnoses ProSeal insertion into the glottis. Anesth Analg. 2002;94:1671-2 pubmed
  43. Tsuji H, Kiba T, Nagata M, Inoue T, Yukawa H, Yamashita T, et al. A phase I study of concurrent chemoradiotherapy with S-1 for T2N0 glottic carcinoma. Oncology. 2006;71:369-73 pubmed
    ..Endpoints of this study were to examine the toxicity profile of this regimen and to determine the recommended dose of S-1...
  44. Kraas J, Underhill T, D Agostino R, Williams D, Cox J, Greven K. Quantitative analysis from CT is prognostic for local control of supraglottic carcinoma. Head Neck. 2001;23:1031-6 pubmed
    ..The purpose of this study was to determine whether pretreatment imaging with CT was prognostic for control of the primary site in patients with squamous cell carcinoma of the supraglottic larynx...
  45. Yamazaki H, Nishiyama K, Tanaka E, Koizumi M, Chatani M. Radiotherapy for early glottic carcinoma (T1N0M0): results of prospective randomized study of radiation fraction size and overall treatment time. Int J Radiat Oncol Biol Phys. 2006;64:77-82 pubmed
    ..To investigate in a prospective randomized study the effect of radiation fraction size and overall treatment time on the local control of early glottic carcinoma...
  46. Jiang J, Tao C. The minimum glottal airflow to initiate vocal fold oscillation. J Acoust Soc Am. 2007;121:2873-81 pubmed
    ..Furthermore, it was predicted that a divergent glottis or low vocal tract resistance lead to a reduced PTF...
  47. Peretti G, Piazza C, Cattaneo A, De Benedetto L, Martin E, Nicolai P. Comparison of functional outcomes after endoscopic versus open-neck supraglottic laryngectomies. Ann Otol Rhinol Laryngol. 2006;115:827-32 pubmed
    ..The aim of this study was to retrospectively evaluate functional outcomes after ESL in comparison with ONSL...
  48. Hoffman H, Porter K, Karnell L, Cooper J, Weber R, Langer C, et al. Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope. 2006;116:1-13 pubmed
    ..Survival has decreased among patients with laryngeal cancer during the past 2 decades in the United States. During this same period, there has been an increase in the nonsurgical treatment of laryngeal cancer...
  49. Mendenhall W, Amdur R, Morris C, Hinerman R. T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol. 2001;19:4029-36 pubmed
    ..The end results after radiation therapy for T1-T2N0 glottic carcinoma vary considerably. We analyze patient-related and treatment-related parameters that may influence the likelihood of cure...
  50. Bron L, Soldati D, Zouhair A, Ozsahin M, Brossard E, Monnier P, et al. Treatment of early stage squamous-cell carcinoma of the glottic larynx: endoscopic surgery or cricohyoidoepiglottopexy versus radiotherapy. Head Neck. 2001;23:823-9 pubmed
    ..We retrospectively analyze and compare the oncological outcome of patients treated in a single institution, either by endoscopic surgery or partial supracricoid laryngectomy versus radiation therapy...
  51. Nassif R, Loughran S, Moyes C, MacKenzie K. Negative pathology following endoscopic resection of T1a squamous carcinoma of the glottis. J Laryngol Otol. 2005;119:592-4 pubmed
    ..We conclude that a significant number of early squamous carcinomas of the glottis present with very small localized, minimally invasive disease and that a proportion may be treated by biopsy alone...
  52. Roh J, Kim D, Kim S, Park C. Quality of life and voice in patients after laser cordectomy for Tis and T1 glottic carcinomas. Head Neck. 2007;29:1010-6 pubmed
    ..We prospectively examined QOL and vocal function of patients with carcinoma in situ (Tis) or T1 glottic carcinomas after laser cordectomy...
  53. Peeters A, van Gogh C, Goor K, Verdonck de Leeuw I, Langendijk J, Mahieu H. Health status and voice outcome after treatment for T1a glottic carcinoma. Eur Arch Otorhinolaryngol. 2004;261:534-40 pubmed
    ..Patients selected for endoscopic laser surgery on average report fewer voice-related problems than those who underwent radiotherapy...
  54. Chera B, Amdur R, Morris C, Kirwan J, Mendenhall W. T1N0 to T2N0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy. Int J Radiat Oncol Biol Phys. 2010;78:461-6 pubmed publisher
    ..To report the treatment outcomes of definitive radiotherapy (RT) for early-stage squamous cell carcinoma (SCCA) of the glottic larynx...
  55. Alipour F, Scherer R. Flow separation in a computational oscillating vocal fold model. J Acoust Soc Am. 2004;116:1710-9 pubmed
    ..computational model that solves the time-dependent glottal airflow within a forced-oscillation model of the glottis was employed to study glottal flow separation...
  56. Kumamoto Y, Masuda M, Kuratomi Y, Toh S, Shinokuma A, Chujo K, et al. "FAR" chemoradiotherapy improves laryngeal preservation rates in patients with T2N0 glottic carcinoma. Head Neck. 2002;24:637-42 pubmed
    ..v.), vitamin A (50,000 unit/day, i.m.) and external radiation (2.0 Gy/day), which we have termed "FAR therapy."..
  57. Ahmed W, Suzuki K, Imaeda Y, Horibe Y. Ki-67, p53 and epidermal growth factor receptor expression in early glottic cancer involving the anterior commissure treated with radiotherapy. Auris Nasus Larynx. 2008;35:213-9 pubmed
  58. Jin J, Liao Z, Gao L, Huang X, Xu G. Analysis of prognostic factors for T(1)N(0)M(0) glottic cancer treated with definitive radiotherapy alone: experience of the cancer hospital of Peking Union Medical College and the Chinese Academy Of Medical Sciences. Int J Radiat Oncol Biol Phys. 2002;54:471-8 pubmed
    ..To analyze the prognostic factors for early-stage glottic cancer (T(1)N(0)M(0)) treated with radiotherapy alone...
  59. Garden A, Forster K, Wong P, Morrison W, Schechter N, Ang K. Results of radiotherapy for T2N0 glottic carcinoma: does the "2" stand for twice-daily treatment?. Int J Radiat Oncol Biol Phys. 2003;55:322-8 pubmed
    ..This retrospective study updated the results of RT for patients treated at our center. The primary focus of this study was whether a policy of using hyperfractionated RT for these patients resulted in a therapeutic gain...
  60. Yiotakis J, Stavroulaki P, Nikolopoulos T, Manolopoulos L, Kandiloros D, Ferekidis E, et al. Partial laryngectomy after irradiation failure. Otolaryngol Head Neck Surg. 2003;128:200-9 pubmed
    Radiation therapy is often the first method of treating patients with early cancer of the glottis. There is a substantial failure rate among these patients...
  61. Kotby M, Hegazi M, Kamal I, Gamal El Dien N, Nassar J. Aerodynamics of the pseudo-glottis. Folia Phoniatr Logop. 2009;61:24-8 pubmed publisher
    The aim of this work is to study the hitherto unclear aerodynamic parameters of the pseudo-glottis following total laryngectomy...
  62. Groome P, O Sullivan B, Mackillop W, Jackson L, Schulze K, Irish J, et al. Compromised local control due to treatment interruptions and late treatment breaks in early glottic cancer: Population-based outcomes study supporting need for intensified treatment schedules. Int J Radiat Oncol Biol Phys. 2006;64:1002-12 pubmed
    ..This population-based study describes the treatment of early glottic cancer in Ontario, Canada and assesses whether treatment variations were associated with treatment effectiveness...
  63. Ganly I, Patel S, Matsuo J, Singh B, Kraus D, Boyle J, et al. Results of surgical salvage after failure of definitive radiation therapy for early-stage squamous cell carcinoma of the glottic larynx. Arch Otolaryngol Head Neck Surg. 2006;132:59-66 pubmed
    ..To report the outcome of surgical salvage performed for early-stage squamous cell carcinoma of the glottic larynx that recurred or progressed after definitive radiotherapy...
  64. Seymour A, Prakash N. A cadaver study to measure the adult glottis and subglottis: defining a problem associated with the use of double-lumen tubes. J Cardiothorac Vasc Anesth. 2002;16:196-8 pubmed
    To test the hypothesis that the adult cricoid diameter is the same or less than that of the glottis.
  65. Sasaki C, Jassin B, Kim Y, Hundal J, Rosenblatt W, Ross D. Central facilitation of the glottic closure reflex in humans. Ann Otol Rhinol Laryngol. 2003;112:293-7 pubmed
    ..A precise understanding of this effect may improve the prevention of aspiration in patients emerging from prolonged sedation or under heavy psychotropic control...
  66. Ng B, Goy R, Bain J, Chen F, Liu E. The impact of manual in-line stabilisation on ventilation and visualisation of the glottis with the LMA CTrach: a randomised crossover trial. Anaesthesia. 2009;64:894-8 pubmed publisher
    The LMA CTrach (CTrach) enables ventilation, glottis visualisation and tracheal intubation via a laryngeal mask conduit...
  67. Bradley P, MacKenzie K, Wight R, Pracy P, Paleri V. Consensus statement on management in the UK: transoral laser assisted microsurgical resection of early glottic cancer. Clin Otolaryngol. 2009;34:367-73 pubmed publisher
    ..In the absence of the results from randomised clinical trials, clinicians may be guided by an expert panel consensus statement on transoral laser assisted microsurgical resection of early squamous cell cancer of the larynx...
  68. Bradley P, Ferlito A, Suarez C, Werner J, Genden E, Shaha A, et al. Options for salvage after failed initial treatment of anterior vocal commissure squamous carcinoma. Eur Arch Otorhinolaryngol. 2006;263:889-94 pubmed
    ..However, total laryngectomy may remain the only treatment option for advanced or aggressive first time recurrence, or in patients who develop subsequent recurrence following previous less aggressive surgery (endoscopic or external)...
  69. Ambrosch P. The role of laser microsurgery in the treatment of laryngeal cancer. Curr Opin Otolaryngol Head Neck Surg. 2007;15:82-8 pubmed
    ..The outcomes of laser microsurgical treatment of laryngeal carcinomas are reviewed and compared with the results of competitive standard procedures...
  70. Loughran S, Calder N, MacGregor F, Carding P, MacKenzie K. Quality of life and voice following endoscopic resection or radiotherapy for early glottic cancer. Clin Otolaryngol. 2005;30:42-7 pubmed
  71. Steiner W, Ambrosch P, Rödel R, Kron M. Impact of anterior commissure involvement on local control of early glottic carcinoma treated by laser microresection. Laryngoscope. 2004;114:1485-91 pubmed
    ..To analyze the impact of anterior commissure involvement on local control, survival, and laryngeal preservation in patients with early glottic cancer (pT1a-pT2a) treated with unimodality laser microsurgical resection...
  72. Cellai E, Frata P, Magrini S, Paiar F, Barca R, Fondelli S, et al. Radical radiotherapy for early glottic cancer: Results in a series of 1087 patients from two Italian radiation oncology centers. I. The case of T1N0 disease. Int J Radiat Oncol Biol Phys. 2005;63:1378-86 pubmed
  73. Sjögren E, Wiggenraad R, le Cessie S, Snijder S, Pomp J, Baatenburg de Jong R. Outcome of radiotherapy in T1 glottic carcinoma: a population-based study. Eur Arch Otorhinolaryngol. 2009;266:735-44 pubmed publisher
    ..No factor was predictive for disease specific survival. Pre-existent laryngeal hypertrophic laryngitis is a new risk factor associated with reduced local control in T1 glottic carcinoma treated with radiotherapy...
  74. Sjögren E, van Rossum M, Langeveld T, Voerman M, van de Kamp V, Friebel M, et al. Voice outcome in T1a midcord glottic carcinoma: laser surgery vs radiotherapy. Arch Otolaryngol Head Neck Surg. 2008;134:965-72 pubmed publisher
    ..To compare voice quality after radiotherapy or endoscopic laser surgery in patients with similar T1a midcord glottic carcinomas according to a validated multidimensional protocol...
  75. Akimoto T, Nonaka T, Kitamoto Y, Ishikawa H, Ninomiya H, Chikamatsu K, et al. Radiation therapy for T2N0 laryngeal cancer: A retrospective analysis for the impact of concurrent chemotherapy on local control. Int J Radiat Oncol Biol Phys. 2006;64:995-1001 pubmed
    ..The impact of concurrent chemotherapy on the local control in patients with T2N0 laryngeal cancer who receive radiation therapy (RT) was evaluated...
  76. Herranz J, Gavilan J, Vázquez Barros J. [Carcinoma of the anterior commissure]. Acta Otorrinolaringol Esp. 2007;58:367-70 pubmed
    ..There is no scientific data to support recommendations for the most effective treatment in patients with squamous cell carcinoma of the anterior commissure. The available evidence is level 5, with a D recommendation grade...
  77. Vilaseca I, Huerta P, Blanch J, Fernández Planas A, Jiménez C, Bernal Sprekelsen M. Voice quality after CO2 laser cordectomy--what can we really expect?. Head Neck. 2008;30:43-9 pubmed
    ..We evaluated the voice quality after laser cordectomy for early glottic cancer in a variety of vocal situations and its relation with the extension of resection and the age...