larynx

Summary

Summary: A tubular organ of VOICE production. It is located in the anterior neck, superior to the TRACHEA and inferior to the tongue and HYOID BONE.

Top Publications

  1. Herbst C, Svec J, Lohscheller J, Frey R, Gumpenberger M, Stoeger A, et al. Complex vibratory patterns in an elephant larynx. J Exp Biol. 2013;216:4054-64 pubmed publisher
    ..To date, little is known in detail about the vibratory phenomena in the elephant larynx. Here, we provide a first descriptive report of the complex oscillatory features found in the excised larynx of a ..
  2. Colović Z, Pešutić Pisac V, Poljak N, Racic G, Cikojević D, Kontić M. Expression of matrix metalloproteinase-9 in patients with squamous cell carcinoma of the larynx. Coll Antropol. 2013;37:151-5 pubmed
    ..Study included 196 patients with squamous cell carcinoma of the larynx treated at ENT Department, Split University Hospital Centre, from January 1, 2000 till December 31, 2009...
  3. Wang J, Gao J, Li Y, Zhao X, Gao W, Peng L, et al. Functional polymorphisms in FAS and FASL contribute to risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population. Gene. 2013;524:193-6 pubmed publisher
    ..However, their roles in the development of larynx and hypopharynx squamous cell carcinoma (SCC) were still unknown in the Chinese...
  4. Forastiere A, Zhang Q, Weber R, Maor M, Goepfert H, Pajak T, et al. Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol. 2013;31:845-52 pubmed publisher
    To report the long-term results of the Intergroup Radiation Therapy Oncology Group 91-11 study evaluating the contribution of chemotherapy added to radiation therapy (RT) for larynx preservation.
  5. Filou S, Stylianou M, Triantaphyllidou I, Papadas T, Mastronikolis N, Goumas P, et al. Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma. Biochimie. 2013;95:725-34 pubmed publisher
    ..organization and localization of ADAMTS-1, ADAMTS-4/aggrecanase-1 and ADAMTS-5/aggrecanase-2 in human normal larynx and laryngeal squamous cell carcinoma (LSCC) were investigated...
  6. Chernock R, Wang X, Gao G, Lewis J, Zhang Q, Thorstad W, et al. Detection and significance of human papillomavirus, CDKN2A(p16) and CDKN1A(p21) expression in squamous cell carcinoma of the larynx. Mod Pathol. 2013;26:223-31 pubmed publisher
    ..058). Thus, it appears that the role of HPV is more complex in the larynx than in the oropharynx, and that CDKN2A(p16) and CDKN1A(p21) expression may not reflect HPV-driven tumors in most ..
  7. de Oliveira Semenzati G, de Souza Salgado B, Rocha N, Michelin Matheus S, de Carvalho L, Garcia Martins R. Histological and immunohistochemical study of the expression of p53 and ki-67 proteins in the mucosa of the tongue, pharynx and larynx of rats exposed to cigarette smoke. Inhal Toxicol. 2012;24:723-31 pubmed publisher
    Head and neck cancers are linked to smoking. The most affected sites are the oral cavity, pharynx and larynx. Experimental studies show epithelial lesions caused by cigarette smoke.
  8. Chansaenroj J, Theamboonlers A, Junyangdikul P, Supiyaphan P, Poovorawan Y. Whole genome analysis of human papillomavirus genotype 11 from cervix, larynx and lung. Asian Pac J Cancer Prev. 2012;13:2619-23 pubmed
    ..In this study HPV11 positive specimens were selected from cervix, larynx and lung biopsy tissue to analyze the whole genome by PCR and direct sequencing...
  9. Caglar H, Tishler R, Othus M, Burke E, Li Y, Goguen L, et al. Dose to larynx predicts for swallowing complications after intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2008;72:1110-8 pubmed publisher
    ..To evaluate early swallowing after intensity-modulated radiotherapy for head and neck squamous cell carcinoma and determine factors correlating with aspiration and/or stricture...

More Information

Publications62

  1. Titiz A, Ozcakir O, Ceyhan S, Yilmaz Y, Unal A, Akyon Y. The presence of Helicobacter pylori in the larynx pathologies. Auris Nasus Larynx. 2008;35:534-8 pubmed publisher
    ..carcinoma suggested a possible presence in the laryngeal tissues of patients with squamous cell carcinoma of the larynx by using Polymerase Chain Reaction (PCR) investigations, and PCR results of benign laryngeal pathologies were ..
  2. Nasipak B, Kelley D. The genome of the diploid anuran Xenopus tropicalis contains a novel array of sarcoplasmic myosin heavy chain genes expressed in larval muscle and larynx. Dev Genes Evol. 2008;218:389-97 pubmed publisher
    ..The isoforms in this array are expressed during larval stages and in muscles of the adult larynx. Duplication of the fast-skeletal MyHC array appears to have led to expression divergence of muscle proteins in ..
  3. Baur L, Nasipak B, Kelley D. Sexually differentiated, androgen-regulated, larynx-specific myosin heavy-chain isoforms in Xenopus tropicalis; comparison to Xenopus laevis. Dev Genes Evol. 2008;218:371-9 pubmed publisher
    ..that the sarcoplasmic myosin heavy-chain (MyHC) isoform xtMyHC-101d is highly and specifically expressed in the larynx of the aquatic anuran, Xenopus tropicalis...
  4. Guo S, Yu L, Sepehr A, Perez J, Su J, Ridgway J, et al. Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx. J Biomed Opt. 2009;14:014017 pubmed publisher
    ..Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy...
  5. Gilad R, Milillo P, Som P. Severe diffuse systemic amyloidosis with involvement of the pharynx, larynx, and trachea: CT and MR findings. AJNR Am J Neuroradiol. 2007;28:1557-8 pubmed
    ..We present the case of a patient with severe diffuse systemic amyloidosis with extensive involvement of the pharynx, larynx, trachea, lungs, eyelids, and breasts. We also review the imaging characteristics and pertinent literature.
  6. Heman Ackah Y, Mandel S, Manon Espaillat R, Abaza M, Sataloff R. Laryngeal electromyography. Otolaryngol Clin North Am. 2007;40:1003-23, vi-vii pubmed
    Laryngeal electromyography (LEMG) evaluates the integrity of the neuromuscular system in the larynx by recording action potentials generated in the laryngeal muscles during voluntary and involuntary contraction...
  7. Rubinstein M, Fine E, Sepehr A, Armstrong W, Crumley R, Kim J, et al. Optical coherence tomography of the larynx using the Niris system. J Otolaryngol Head Neck Surg. 2010;39:150-6 pubmed
  8. Jalisi S, Zoccoli M. Management of laryngeal fractures--a 10-year experience. J Voice. 2011;25:473-9 pubmed publisher
    ..Herein, we present one of the largest series of management of laryngeal and tracheal fractures from a tertiary care level I trauma center...
  9. GELLER K, Kim Y, Koempel J, Anderson K. Surgical management of type III and IV laryngotracheoesophageal clefts: the three-layered approach. Int J Pediatr Otorhinolaryngol. 2010;74:652-7 pubmed publisher
  10. Mostafa B, Shafik A, Fawaz S. The role of flexible autofluorescence laryngoscopy in the diagnosis of malignant lesions of the larynx. Acta Otolaryngol. 2007;127:175-9 pubmed
    ..Autofluorescent endoscopy (AFE) combined with microlaryngoscopy (MLS) gives a more accurate diagnosis of laryngeal pathology and can be further refined to minimize the need for MLS under general anaesthesia...
  11. Kabak M, Orhan I, Haziroglu R. The gross anatomy of larynx, trachea and syrinx in the long-legged buzzard (Buteo rufinus). Anat Histol Embryol. 2007;36:27-32 pubmed
    ..It was determined that long-legged buzzards' larynx is composed of three different cartilages...
  12. Maranillo E, Vazquez T, Mirapeix R, Leon X, McHanwell S, Quer M, et al. Ceratocricoid muscle: an embryological and anatomical study. Clin Anat. 2009;22:463-70 pubmed publisher
    ..This may be a possible explanation for the causation of certain idiopathic recurrent laryngeal nerve palsies...
  13. Gale N, Michaels L, Luzar B, Poljak M, Zidar N, Fischinger J, et al. Current review on squamous intraepithelial lesions of the larynx. Histopathology. 2009;54:639-56 pubmed publisher
    Squamous intraepithelial lesions (SILs) of the larynx, clinically usually defined as leukoplakia and chronic laryngitis, have remained the main controversial topic in laryngeal pathology for decades as regards classification, histological ..
  14. Giordano G, Corcione L, Giordano D, D Adda T, Gnetti L, Ferri T. Primary moderately differentiated neuroendocrine carcinoma (atypical carcinoid) of the larynx: A case report with immunohistochemical and molecular study. Auris Nasus Larynx. 2009;36:228-31 pubmed publisher
    ..paper, we report the case of a moderately differentiated neuroendocrine carcinoma NEC (atypical carcinoid) of the larynx in a heavy smoker 67-year-old woman, with a history of hoarseness, dysphagia and dyspnea...
  15. Fritz D, Hu A, Wilson T, Ladak H, Haase P, Fung K. Long-term retention of a 3-dimensional educational computer model of the larynx: a follow-up study. Arch Otolaryngol Head Neck Surg. 2011;137:598-603 pubmed publisher
    To determine the long-term retention of a 3-dimentional (3-D) educational computer model of the larynx to teach laryngeal anatomy and to compare it with standard written instruction (SWI).
  16. Dietz A, Rudat V, Dreyhaupt J, Pritsch M, Hoppe F, Hagen R, et al. Induction chemotherapy with paclitaxel and cisplatin followed by radiotherapy for larynx organ preservation in advanced laryngeal and hypopharyngeal cancer offers moderate late toxicity outcome (DeLOS-I-trial). Eur Arch Otorhinolaryngol. 2009;266:1291-300 pubmed publisher
    A prospective multicenter phase-II trial (12 centers) was performed by the German larynx organ preservation group (DeLOS) to evaluate the effect of induction chemotherapy (ICHT) with paclitaxel/cisplatin (TP), followed by accelerated-..
  17. Rahbar R, Rouillon I, Roger G, Lin A, Nuss R, Denoyelle F, et al. The presentation and management of laryngeal cleft: a 10-year experience. Arch Otolaryngol Head Neck Surg. 2006;132:1335-41 pubmed
    ..To review the presentation and associated congenital abnormalities of laryngeal cleft and present guidelines for its evaluation and management...
  18. Silistino Souza R, Rodrigues Lisoni F, Cury P, Maniglia J, Raposo L, Tajara E, et al. Annexin 1: differential expression in tumor and mast cells in human larynx cancer. Int J Cancer. 2007;120:2582-9 pubmed
    Annexin 1 protein (ANXA1) expression was evaluated in tumor and mast cells in human larynx cancer and control epithelium...
  19. Kutta H, Knipping S, Claassen H, Paulsen F. [Functional anatomy of the larynx from clinical viewpoints. Part I: development, laryngeal skeleton, joints, insertion structures, musculature]. HNO. 2007;55:583-98 pubmed
    ENT specialist and phoniatricians are not the only professionals for whom diseases of the larynx occupy centre stage; this applies to those in all fields involving conservative or surgical treatment of the larynx, such as speech ..
  20. Schraff S, Zur K, Jacobs I, Darrow D, Cotton R, Rutter M. The clinical relevance of the submucosal cricoid cleft. Int J Pediatr Otorhinolaryngol. 2007;71:1099-104 pubmed
    ..The submucosal cleft variant has been described anatomically, but not clinically. We describe a series of patients with a submucosal cricoid cleft variant and its clinical relevance...
  21. Honda Y, Hata N. Dynamic imaging of swallowing in a seated position using open-configuration MRI. J Magn Reson Imaging. 2007;26:172-6 pubmed
    ..To assess the feasibility of dynamic MRI of swallowing in a seated position using an open-configuration MRI scanner, and to compare its capacity for motion analysis around the pharyngeal wall with that of videofluorography...
  22. Akdogan O, Ibrahim O, Selcuk A, Dere H. The association of laryngoceles with squamous cell carcinoma of the larynx presenting as a deep neck infection. B-ENT. 2007;3:209-11 pubmed
    ..We present a case of an external laryngocele with laryngeal carcinoma...
  23. Dornfeld K, Simmons J, Karnell L, Karnell M, Funk G, Yao M, et al. Radiation doses to structures within and adjacent to the larynx are correlated with long-term diet- and speech-related quality of life. Int J Radiat Oncol Biol Phys. 2007;68:750-7 pubmed
    ..To test the hypothesis that radiation dose to key sites in the upper aerodigestive tract is associated with long-term functional outcome after (chemo)radiotherapy for head-and-neck cancers...
  24. Lowell S, Kelley R, Colton R, Smith P, Portnoy J. Position of the hyoid and larynx in people with muscle tension dysphonia. Laryngoscope. 2012;122:370-7 pubmed publisher
  25. Xu W, Han D, Hou L, Hu R, Wang L. Clinical and electrophysiological characteristics of larynx in myasthenia gravis. Ann Otol Rhinol Laryngol. 2009;118:656-61 pubmed
    We investigated the clinical and electrophysiological characteristics of the larynx in patients with myasthenia gravis (MG).
  26. Alonso Guervós M, Alvarez Marcos C, Llorente J, Sampedro Nuño A, Suarez C, Hermsen M. Genetic differences between primary larynx and pharynx carcinomas and their matched lymph node metastases by multiplex ligation-dependent probe amplification. Oral Oncol. 2009;45:600-4 pubmed publisher
    Lymph nodes metastasis is a major risk factor related to poor survival in larynx and pharynx carcinomas...
  27. Zhang Y, Jiang J. Asymmetric spatiotemporal chaos induced by a polypoid mass in the excised larynx. Chaos. 2008;18:043102 pubmed publisher
    ..the laryngeal pathology of a vocal polyp is experimentally observed using high-speed imaging in an excised larynx. Spatiotemporal analysis reveals that the normal vocal folds show spatiotemporal correlation and symmetry...
  28. Abdelkafy W, Smith J, Henriquez O, Golub J, Xu J, Rojas M, et al. Age-related changes in the murine larynx: initial validation of a mouse model. Ann Otol Rhinol Laryngol. 2007;116:618-22 pubmed
    ..With changing age demographics in our society and increasing emphasis on quality of life, treatment of presbylaryngis is becoming more paramount...
  29. Kaplan M, Hagberg C, Ward D, Brambrink A, Chhibber A, Heidegger T, et al. Comparison of direct and video-assisted views of the larynx during routine intubation. J Clin Anesth. 2006;18:357-62 pubmed
    ..To compare the direct and indirect (video monitor) views of the glottic opening using a new Macintosh blade that is modified to provide a video image of airway structures during laryngoscopy...
  30. Riede T. Subglottal pressure, tracheal airflow, and intrinsic laryngeal muscle activity during rat ultrasound vocalization. J Neurophysiol. 2011;106:2580-92 pubmed publisher
    ..Many features of the laryngeal muscle activation pattern during ultrasound vocalization in rats are shared with other mammals...
  31. Van Lierde K, De Bodt M, Dhaeseleer E, Wuyts F, Claeys S. The treatment of muscle tension dysphonia: a comparison of two treatment techniques by means of an objective multiparameter approach. J Voice. 2010;24:294-301 pubmed publisher
    ..Further research into this topic could focus on electromyography (EMG) recordings in relation to vocal improvements with larger sample of subjects...
  32. Kurosu A, Logemann J. Gender effects on airway closure in normal subjects. Dysphagia. 2010;25:284-90 pubmed publisher
    ..0001) and cricopharyngeal opening (P < 0.0001). During liquid barium swallows there was a linear increase in both the duration of laryngeal closure and cricopharyngeal opening...
  33. Barker E, Murison P, Macchiarini P, Jones A, Otto C, Rothkoetter H, et al. Early immunological changes associated with laryngeal transplantation in a major histocompatibility complex-matched pig model. Clin Exp Immunol. 2006;146:503-8 pubmed
    Laryngeal transplantation is an increasingly viable proposition for patients with irreversible diseases of the larynx. One human transplant has been performed successfully, but many questions remain before routine transplantation can ..
  34. Terk A, Leder S, Burrell M. Hyoid bone and laryngeal movement dependent upon presence of a tracheotomy tube. Dysphagia. 2007;22:89-93 pubmed
    ..tube and tube cuff status, tube capping status, and aspiration status on movement of the hyoid bone and larynx during normal swallowing...
  35. Midi I, Dogan M, Koseoglu M, Can G, Sehitoglu M, Gunal D. Voice abnormalities and their relation with motor dysfunction in Parkinson's disease. Acta Neurol Scand. 2008;117:26-34 pubmed
  36. Vazquez T, Cobiella R, Maranillo E, Valderrama F, McHanwell S, Parkin I, et al. Anatomical variations of the superior thyroid and superior laryngeal arteries. Head Neck. 2009;31:1078-85 pubmed publisher
    ..There are known to be variations in the origins of the superior thyroid artery (STA), an important surgical landmark, and 1 of its branches, the superior laryngeal artery (SLA)...
  37. Echternach M, Mencke T, Richter B, Reber A. [Laryngeal alterations following endotracheal intubation and use of larynx masks]. HNO. 2011;59:485-98 pubmed publisher
    ..Most prevalently, swollen mucosa, hematomas, granuloma and edema in the larynx can be observed after intubation. Limitations of respiratory vocal fold mobility appear less frequently...
  38. Tokuda I, Horácek J, Svec J, Herzel H. Comparison of biomechanical modeling of register transitions and voice instabilities with excised larynx experiments. J Acoust Soc Am. 2007;122:519-31 pubmed
    Voice instabilities were studied using excised human larynx experiments and biomechanical modeling. With a controlled elongation of the vocal folds, the experiments showed registers with chest-like and falsetto-like vibrations...
  39. JOHNSON A, Ciucci M, Russell J, HAMMER M, Connor N. Ultrasonic output from the excised rat larynx. J Acoust Soc Am. 2010;128:EL75-9 pubmed publisher
    The source of ultrasonic vocalizations (USVs) produced by rats is thought to be within the larynx. The purpose of this investigation was to determine if the rat larynx is capable of producing ultrasounds with the full range of frequencies ..
  40. Elemans C, Laje R, Mindlin G, Goller F. Smooth operator: avoidance of subharmonic bifurcations through mechanical mechanisms simplifies song motor control in adult zebra finches. J Neurosci. 2010;30:13246-53 pubmed publisher
    ..Consistent with this view is the presence of high fidelity at every level of motor control, from telencephalic premotor areas to superfast syringeal muscles...
  41. Shao T, Yang W, Zhang T, Wang Y, Jin X, Li Q, et al. A newly identified variation at the entry of the recurrent laryngeal nerve into the larynx. J Invest Surg. 2010;23:314-20 pubmed publisher
    ..We aimed to highlight a new anatomical variation of the recurrent laryngeal nerve (RLN), and to emphasize its implications for thyroid surgery...
  42. Mathur N, Peek G, Bailey C, Elliott M. Strategies for managing Type IV laryngotracheoesophageal clefts at Great Ormond Street Hospital for Children. Int J Pediatr Otorhinolaryngol. 2006;70:1901-10 pubmed
    ..To review our strategy for the treatment of patients with Type IV laryngotracheoesophageal cleft-a very rare congenital malformation...
  43. Lefebvre J, Ang K. Larynx preservation clinical trial design: key issues and recommendations-a consensus panel summary. Int J Radiat Oncol Biol Phys. 2009;73:1293-303 pubmed publisher
    To develop guidelines for the conduct of Phase III clinical trials of larynx preservation in patients with locally advanced laryngeal and hypopharyngeal cancer.
  44. Dornfeld K, Hopkins S, Simmons J, Spitz D, Menda Y, Graham M, et al. Posttreatment FDG-PET uptake in the supraglottic and glottic larynx correlates with decreased quality of life after chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2008;71:386-92 pubmed publisher
    ..We sought to determine whether increased glucose uptake in normal tissues after chemoradiotherapy is associated with increased toxicity...
  45. Alipour F, Scherer R. On pressure-frequency relations in the excised larynx. J Acoust Soc Am. 2007;122:2296-305 pubmed
    ..to find relationships between subglottal pressure (P(s)) and fundamental frequency (F(0)) of phonation in excised larynx models. This included also the relation between F(0) and its rate of change with pressure (dFdP)...
  46. Damrose E. Quantifying the impact of androgen therapy on the female larynx. Auris Nasus Larynx. 2009;36:110-2 pubmed publisher
    ..To describe the timing of changes in fundamental frequency of the female voice following androgen therapy during female to male gender reassignment...
  47. Suthers R, Narins P, Lin W, Schnitzler H, Denzinger A, Xu C, et al. Voices of the dead: complex nonlinear vocal signals from the larynx of an ultrasonic frog. J Exp Biol. 2006;209:4984-93 pubmed
    ..of its calls, responsible for this frog's vocal diversity, can be generated by forcing pressurized air through the larynx of euthanized males...
  48. Yoo G, Moon J, LeBlanc M, Lonardo F, Urba S, Kim H, et al. A phase 2 trial of surgery with perioperative INGN 201 (Ad5CMV-p53) gene therapy followed by chemoradiotherapy for advanced, resectable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx: report of the Southwest Oncology . Arch Otolaryngol Head Neck Surg. 2009;135:869-74 pubmed publisher
    ..of treating patients with high-risk stage III and IV squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx with perioperative adenovirus-p53 (INGN 201) gene therapy along with surgery and chemoradiotherapy.
  49. Lefebvre J, Ang K. Larynx preservation clinical trial design: key issues and recommendations--a consensus panel summary. Head Neck. 2009;31:429-41 pubmed publisher
    To develop guidelines for the conduct of phase III clinical trials of larynx preservation in patients with locally advanced laryngeal and hypopharyngeal cancer.
  50. Nishimura T, Oishi T, Suzuki J, Matsuda K, Takahashi T. Development of the supralaryngeal vocal tract in Japanese macaques: implications for the evolution of the descent of the larynx. Am J Phys Anthropol. 2008;135:182-94 pubmed
    ..This configuration develops from the great descent of the larynx relative to the palate, which is accomplished through both the descent of the laryngeal skeleton relative to the ..
  51. Vicini C, de Vito A, Benazzo M, Frassineti S, Campanini A, Frasconi P, et al. The nose oropharynx hypopharynx and larynx (NOHL) classification: a new system of diagnostic standardized examination for OSAHS patients. Eur Arch Otorhinolaryngol. 2012;269:1297-300 pubmed publisher
  52. Hughes O, Stone N, Kraft M, Arens C, Birchall M. Optical and molecular techniques to identify tumor margins within the larynx. Head Neck. 2010;32:1544-53 pubmed publisher
    Failure to remove tumor cells from the larynx significantly increases the risk of local recurrence following surgical excision. Healthy tissue must be preserved to optimize long-term vocal and swallowing function...
  53. Reynolds C, Martinez S, Furr A, Cunningham M, Bumpous J, Lentsch E, et al. Risk acceptance in laryngeal transplantation. Laryngoscope. 2006;116:1770-5 pubmed
    ..of head and neck surgery and immunology have paved the way for new quality of life-improving procedures such as larynx transplantation...