Summary: Inflammation of the LARYNGEAL MUCOSA, including the VOCAL CORDS. Laryngitis is characterized by irritation, edema, and reduced pliability of the mucosa leading to VOICE DISORDERS such as APHONIA and HOARSENESS.

Top Publications

  1. Kaltoft M, Munch Petersen H, Møller H. [Leishmaniasis isolated to the larynx as cause of chronic laryngitis]. Ugeskr Laeger. 2010;172:2898-9 pubmed
    ..Polymerase chain reaction showed infection with L. donovani, L. infantum or L. tropica, species which do not normally cause isolated mucosal infection. This is the first reported case from Scandinavia...
  2. Hannu T, Piipari R, Toskala E. Immediate hypersensitivity type of occupational laryngitis in a welder exposed to welding fumes of stainless steel. Am J Ind Med. 2006;49:402-5 pubmed
    Although upper respiratory symptoms have been reported to occur in welders, occupational laryngitis of immediate hypersensitivity type due to welding fumes of stainless steel has not been previously reported...
  3. Rodriguez J, Von Dessauer B, Duffau G. [Non-invasive continuous positive airways pressure for post-extubation laryngitis in pediatric patients]. Arch Bronconeumol. 2002;38:463-7 pubmed
    ..The hypothesis was confirmed. CPAP treatment reduced the failure rate by 53.2% in comparison with conventional therapy. ..
  4. Salminen P, Karvonen J, Ovaska J. Long-term outcomes after laparoscopic Nissen fundoplication for reflux laryngitis. Dig Surg. 2010;27:509-14 pubmed publisher
    The surgical treatment of gastroesophageal reflux-induced reflux laryngitis remains controversial...
  5. Lima Rodrigues M, Valle Fernandes A, Lamas N, Cruz A, Baltazar F, Milanezi F, et al. A new model of laryngitis: neuropeptide, cyclooxygenase, and cytokine profile. Laryngoscope. 2008;118:78-86 pubmed publisher
    ..b>Laryngitis induced by nasogastric intubation (NGI) was evaluated by histopathologic changes of the mucosa, alterations in ..
  6. Gamboa J, Echeverria L, Molina B, Cobeta I. [Stroboscopic assessment of chronic laryngitis]. Acta Otorrinolaringol Esp. 2006;57:266-9 pubmed investigation was performed to relate the stroboscopic results with the anatomopathologic results of chronic laryngitis and glottic cancer...
  7. Morinaka S. Herpes zoster laryngitis with intractable hiccups. Auris Nasus Larynx. 2009;36:606-8 pubmed publisher
    ..Elevation of the CF titer after 2 weeks confirmed the diagnosis of herpes zoster. This condition should be considered in patients with unilateral sore throat and intractable hiccups, and treatment with acyclovir should be provided. ..
  8. Lien H, Wang C, Hsu J, Sung F, Cheng K, Liang W, et al. Classical reflux symptoms, hiatus hernia and overweight independently predict pharyngeal acid exposure in patients with suspected reflux laryngitis. Aliment Pharmacol Ther. 2011;33:89-98 pubmed publisher
    Gastro-oesophageal reflux disease (GERD) has been associated with reflux laryngitis. To investigate the risk factors and the predictors of pharyngeal acid reflux (PAR) in Taiwanese patients with suspected reflux laryngitis...
  9. Laudien M, Ambrosch P, Till A, Podschun R, Lamprecht P. [Diagnosis, therapy and current research aspects of selected chronic inflammatory diseases with head and neck involvement]. Z Rheumatol. 2008;67:397-406 pubmed publisher
    ..Their aetiology, however, is still unclear and treatment leads to a wide spectrum of undesirable effects. Research work is needed to advance diagnostics and therapy in this field. Recent research aspects are presented in this article. ..

More Information


  1. Rantala L, Hakala S, Holmqvist S, Sala E. Connections between voice ergonomic risk factors in classrooms and teachers' voice production. Folia Phoniatr Logop. 2012;64:278-82 pubmed publisher
    ..A practical implication of the results is that voice ergonomic assessments are needed in schools. ..
  2. Esaki S, Goshima F, Kimura H, Ikeda S, Katsumi S, Kabaya K, et al. Auditory and vestibular defects induced by experimental labyrinthitis following herpes simplex virus in mice. Acta Otolaryngol. 2011;131:684-91 pubmed publisher
    ..Our herpes simplex virus (HSV) labyrinthitis mouse model suggests that HSV infection induces vestibular neuritis and sudden deafness...
  3. Mehanna H, Kuo T, Chaplin J, Taylor G, Morton R. Fungal laryngitis in immunocompetent patients. J Laryngol Otol. 2004;118:379-81 pubmed
    The diagnosis of fungal laryngitis is often overlooked in systemically immunocompetent patients because it is commonly considered a disease of the immunocompromised, and because it often mimics, clinically and histologically, more common ..
  4. Loehrl T, Smith T. Inflammatory and granulomatous lesions of the larynx and pharynx. Am J Med. 2001;111 Suppl 8A:113S-117S pubmed
    ..complications of reflux disease, relapsing polychondritis, Wegener granulomatosis, sarcoidosis, tuberculous laryngitis, Teflon (polytetrafluoroethylene fluoropolymer resin; DuPont, Wilmington, DE) granuloma, amyloidosis, rheumatoid ..
  5. Simpson C, Sulica L, Postma G, Rosen C, Amin M, Merati A, et al. Idiopathic ulcerative laryngitis. Laryngoscope. 2011;121:1023-6 pubmed publisher
    Idiopathic ulcerative laryngitis (IUL) is a distinct, clinical entity that presents after a prolonged upper respiratory infection with cough...
  6. Ingle J, Helou L, Li N, Hebda P, Rosen C, Abbott K. Role of steroids in acute phonotrauma: A basic science investigation. Laryngoscope. 2014;124:921-7 pubmed publisher
    Steroids are used for the treatment of laryngitis in vocal performers and other individuals despite the absence of evidence demonstrating their impact on vocal fold inflammation...
  7. Ghirga G, Ghirga P, Palazzi C, Pipere M, Colaiacomo M. Bag-mask ventilation as a temporizing measure in acute infectious upper-airway obstruction: does it really work?. Pediatr Emerg Care. 2001;17:444-6 pubmed
    ..This gastric distension interferes with ventilation by elevating the diaphragm, resulting in a decreased lung volume. Cricoid pressure could prevent gastric distension in these instances and should be recommended. ..
  8. Ling Z, Mukaisho K, Hidaka M, Chen K, Yamamoto G, Hattori T. Duodenal contents reflux-induced laryngitis in rats: possible mechanism of enhancement of the causative factors in laryngeal carcinogenesis. Ann Otol Rhinol Laryngol. 2007;116:471-8 pubmed
    ..Cell proliferation was also evaluated in laryngeal samples by detection of Ki67 antigen. In this reflux model, laryngitis with infiltration of inflammatory cells and proliferation of small mucous glands was evident from 10 weeks after ..
  9. Li H, Wang Y, Li Y. MicroRNA-133a suppresses the proliferation, migration, and invasion of laryngeal carcinoma cells by targeting CD47. Tumour Biol. 2016;: pubmed pathological examination from laryngeal carcinoma patients as the case group were collected, and 20 chronic laryngitis tissues were gathered as the control group...
  10. Jacobs I, Tufano R, Walsh D, Crombleholme T. The temporal course of adenovirus-mediated gene transfer in the rat larynx. Otolaryngol Head Neck Surg. 2002;126:281-9 pubmed
    ..Adenovirus-mediated gene transfer has the potential to deliver growth factors that modulate wound healing and inflammation in the larynx by inhibiting fibrosis. ..
  11. Hueston W, Kaur D. Section four: laryngitis and dysphonia. FP Essent. 2013;415:27-36 pubmed
    Acute laryngitis is most often caused by viral illnesses through direct inflammation of the vocal cords or from irritation due to postnasal drainage...
  12. Schuck A, Biermann M, Pixberg M, Müller S, Heinecke A, Schober O, et al. Acute toxicity of adjuvant radiotherapy in locally advanced differentiated thyroid carcinoma. First results of the multicenter study differentiated thyroid carcinoma (MSDS). Strahlenther Onkol. 2003;179:832-9 pubmed
    ..The majority of patients experience mild to moderate side effects from adjuvant external-beam radiotherapy. At the first follow-up examination, most side effects have subsided. Acute toxicity is tolerable in these patients. ..
  13. Zou J, Lu H, Pan Z. [Clinical study of watermelon frost runhou tablet treatment for pharynx and larynx oral cavity]. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2003;17:253-5 pubmed
    ..Fully recovering from an illness produce effects rate is 80.0%, always there is the efficiency to serve as 96.0%. Watermelon frost runhou tablet is effective good medicine of safety curing the pharynx and larynx disease in oral cavity. ..
  14. Belafsky P, Peake J, Smiley Jewell S, Verma S, Dworkin Valenti J, Pinkerton K. Soot and house dust mite allergen cause eosinophilic laryngitis in an animal model. Laryngoscope. 2016;126:108-12 pubmed publisher
    Chronic laryngitis (CL) is common and costly. One of the most common causes of CL is thought to be laryngopharyngeal reflux, although a significant percentage of individuals fail to get better with acid suppressive therapy...
  15. De Bodt M, Van den Steen L, Mertens F, Raes J, Van Bel L, Heylen L, et al. Characteristics of a Dysphonic Population Referred for Voice Assessment and/or Voice Therapy. Folia Phoniatr Logop. 2015;67:178-86 pubmed publisher FVD, VFN and cysts, whereas men were significantly more often diagnosed with carcinoma, hyperkeratosis, laryngitis, papillomatosis, presbyphonia, puberphonia and VFP...
  16. Dore M, Pedroni A, Pes G, Maragkoudakis E, Tadeu V, Pirina P, et al. Effect of antisecretory therapy on atypical symptoms in gastroesophageal reflux disease. Dig Dis Sci. 2007;52:463-8 pubmed
    ..pain, sialorrhea, hoarseness, globus sensation, chronic coughing, episodic bronchospasm, hiccup, eructations, laryngitis, and pharyngitis). Symptoms were reassessed after a 3-month course of b.i.d. PPI therapy...
  17. Kozakiewicz J, Dec M, Gorczyca Tarnowska J. [The rare case of primary isolated tuberculosis in a 19 year-old patient]. Otolaryngol Pol. 2006;60:607-9 pubmed
    ..The primary diagnosis was laryngitis chronica...
  18. Watelet J, Evrard A, Lawson G, Bonte K, Remacle M, Van Cauwenberge P, et al. Herpes zoster laryngitis: case report and serological profile. Eur Arch Otorhinolaryngol. 2007;264:505-7 pubmed
    ..In this case of VZV reactivation in the sensitive area of the superior laryngeal nerve, serological profiles of VZV IgM and IgG were profoundly modified up to the fourth month. ..
  19. Payne R, Kost K, Frenkiel S, Zeitouni A, Sejean G, Sweet R, et al. Laryngeal inflammation assessed using the reflux finding score in obstructive sleep apnea. Otolaryngol Head Neck Surg. 2006;134:836-42 pubmed
    ..Laryngeal inflammation is prevalent among OSA patients and correlates with laryngeal sensory dysfunction, attenuation of the LAR, and apnea severity. C-4. ..
  20. Amernik K. [Glottis morphology and perceptive--acoustic characteristics of voice and speech in patients with rheumatoid arthritis]. Otolaryngol Pol. 2008;62:105-7 pubmed publisher
  21. Ford C. Treatment of chronic posterior laryngitis with esomeprazole. Laryngoscope. 2006;116:1717-8; author reply 1718 pubmed
  22. Delbrouck C, Hassid S. [Acute upper respiratory tract infections]. Rev Med Brux. 2001;22:A362-6 pubmed
    ..Acute infections of the upper respiratory tract are reviewed from an ENT point of view. Only the most frequent pathologies are taken into account. Clinical presentation and an update of current treatment are presented. ..
  23. Bhutta M, Rance M, Gillett D, Weighill J. Alendronate-induced chemical laryngitis. J Laryngol Otol. 2005;119:46-7 pubmed
    ..Its recognized side-effects include oesophageal irritation and ulceration. The authors describe a case of laryngitis induced by transient contact of this medication with the laryngeal mucosa...
  24. Plaza G, Martínez San Millán J, Martinez Vidal A. [Parapharyngeal abscess: perilaryngeal infrahyoid extension]. Acta Otorrinolaringol Esp. 2001;52:132-8 pubmed
    ..When medical therapy fails, as they are usually medial to the great vessels, it is possible to perform aspiration and drainage transorally, avoiding the need for cervicotomy, in selected cases. ..
  25. Dimitrijevic M, Beljin V, Petrović V, Dukic V. Gastroesophageal reflux disease correlation with posterior laryngitis. Vojnosanit Pregl. 2009;66:383-7 pubmed
    ..The aim of the present study was to establish possible causal relationship between GERD and posterior laryngitis (PL). The study included 103 patients with gastrointestinal complaints...
  26. Brini I, Guerrero A, Hannachi N, Bouguila J, Orth Höller D, Bouhlel A, et al. Epidemiology and clinical profile of pathogens responsible for the hospitalization of children in Sousse area, Tunisia. PLoS ONE. 2017;12:e0188325 pubmed publisher
    ..042). Coronavirus group was statistically associated with the manifestation of bronchiolitis (p = 0.009) and laryngitis (p = 0.017). Streptococcus pneumoniae DNA was detected in 143 (38.44%) of tested samples...
  27. Branski R, Zhou H, Kraus D, Sivasankar M. The effects of cigarette smoke condensate on vocal fold transepithelial resistance and inflammatory signaling in vocal fold fibroblasts. Laryngoscope. 2011;121:601-5 pubmed publisher
    ..These data may suggest a role for the interaction between the inflammatory response in the mucosa and compromised epithelial barrier function, as has been shown in other tissues. ..
  28. Bulsiewicz W, Madanick R. Antireflux surgery in the proton pump inhibitor era. Cleve Clin J Med. 2012;79:273-81 pubmed publisher
    ..We review the current treatment of GERD and discuss how antireflux surgery fits into the overall scheme. ..
  29. Marie J, Bouccara D, Abitbol P, Jankowski R, Perie S. [Current understanding of chronic cough appearing in the ENT context ]. Rev Pneumol Clin. 2006;62:293-8 pubmed
  30. Vaezi M. Review article: the role of pH monitoring in extraoesophageal gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2006;23 Suppl 1:40-9 pubmed
    Gastro-oesophageal reflux disease is associated with several extraoesophageal disease states including laryngitis, asthma, chronic cough and non-cardiac chest pain...
  31. Negroni R, Arechavala A, López Daneri G. [Clinical cases in Medical Mycology. Case No. 14]. Rev Iberoam Micol. 2005;22:60-1 pubmed
  32. Ni G, Qiao Y, Chen W. [Betamethasone injection in chronic hypertrophic laryngitis]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2005;40:56-9 pubmed
    To evaluate the curative effects of Betamethasone for treatment of voice hoarseness of chronic hypertrophic laryngitis. From July, 2001 to December, 2002, 48 cases of the chronic hypertrophic laryngitis had been treated by injected of ..
  33. El Houadfi M, Kichou F, Tazi R, Mouahid M, Kissi B. First report of avian infectious laryngotracheitis in Morocco. Vet Rec. 2005;156:520-1 pubmed
  34. Semeniuk J, Kaczmarski M, Sidor K, Krasnow A, Daniluk U, Matuszewska E. [Gastroesophagopharyngeal reflux in infants and children with recurrent symptoms of the upper respiratory tract]. Pol Merkur Lekarski. 2004;16:461-4 pubmed
    ..From the group of 29 patients with recurrent episodes of the pharyngitis, laryngitis and tracheitis, we evaluated 18 children aged 3 months to 8 years (mean, 4.23 +/- 2...
  35. Osborne R, Avitia S, Zandifar H, Brown J. Adult supraglottitis subsequent to smoking crack cocaine. Ear Nose Throat J. 2003;82:53-5 pubmed
    ..In this article, we describe two of these cases, and we briefly review what is known about this entity and the mechanism of injury. We also provide our recommendations for management. ..
  36. Konermann M, Radu B, Liebetrau M, Rawert B, Heimbucher J, Sanner B. [Nocturnal gastroesophageal reflux as a cause of refractory chronic laryngitis--pathophysiology and management]. Wien Med Wochenschr. 1999;151:142-6 pubmed
    Chronic laryngitis is a common disease with a multifactoral genesis. One of the known causal factors is gastrolaryngeal acid reflux as a consequence of gastroesophageal reflux disease (GERD)...
  37. Kardos P, Malek F. Common Cold - an Umbrella Term for Acute Infections of Nose, Throat, Larynx and Bronchi. Pneumologie. 2017;71:221-226 pubmed publisher
    Acute respiratory tract infections, i.?e. rhinitis, sinusitis, pharyngitis, laryngitis, bronchitis, belong to the most common medical conditions with a high economic burden...
  38. Vaezi M. Laryngitis and gastro-oesophageal reflux disease (GERD): improve laryngoscopic specificity, don't do pH monitoring. Dig Liver Dis. 2004;36:103-4 pubmed
  39. Ryabova M. [The use of fenspiride for the combined treatment of exacerbation of chronic laryngitis]. Vestn Otorinolaringol. 2017;82:66-69 pubmed publisher was to elucidate the efficacy and safety of fenspiride therapy for the treatment of exacerbation of chronic laryngitis associated with an acute respiratory infection...
  40. Watts C, Knickerbocker K. Characteristics of a Treatment-seeking Population in a Private Practice Community Voice Clinic: An Epidemiologic Study. J Voice. 2018;: pubmed publisher
    ..the most common disorder diagnosis was "other," consisting of a varied cluster of etiologies, including reflux laryngitis, chronic cough, bilateral paralysis or paresis, leukoplakia, and polypoid degeneration...
  41. Asaoka D, Nagahara A, Oguro M, Mori H, Nakae K, Izumi Y, et al. Establishment of a reflux esophago-laryngitis model in rats. Dig Dis Sci. 2011;56:1299-308 pubmed publisher
    To investigate the pathophysiology of reflux laryngitis, an experimental model is required.
  42. Solari R, Corti M, Cangelosi D, Escudero M, Negroni R, Saccheri C, et al. Disseminated histoplasmosis with lesions restricted to the larynx in a patient with AIDS. Report of a case and review of the literature. Rev Iberoam Micol. 2007;24:164-6 pubmed
    ..Treatment with amphotericin B followed by itraconazole resulted in complete remission of laryngeal lesions. To our knowledge, this is the third case report of laryngeal histoplasmosis in a patient with AIDS. ..
  43. Knight J, Lively M, Johnston N, Dettmar P, Koufman J. Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux. Laryngoscope. 2005;115:1473-8 pubmed
    ..Detection of pepsin in throat sputum by immunoassay appears to provide a sensitive, noninvasive method to detect LPR. ..
  44. Choi J. Two cases of pharyngolaryngeal zoster advanced to multiple cranial neuropathy. Am J Otolaryngol. 2013;34:369-72 pubmed publisher
    ..All of these lesions tended to lateralize to the ipsilateral side and endoscopic findings suggested VZV infections, which were confirmed by serial serologic examinations. ..
  45. San Miguel Fraile P, Pazo Irazu S, Eiroa Breijo A, Alvarez Alvarez C. [Reinke edema in a patient with respiratory failure]. Enferm Infecc Microbiol Clin. 2006;24:59-60 pubmed
  46. Vandevelde L, Prive D, Vaes P, D Olne D. [Tuberculous laryngitis: not so rare?]. Acta Otorhinolaryngol Belg. 1989;43:363-71 pubmed
    ..The histopathological examination revealed tuberculosis. The laryngeal involvement is the first and single sign of the primary pulmonary form. Recent Belgian epidemiological data are illustrated...
  47. Duvareille C, St Hilaire M, Samson N, Bakirtzian P, Brisebois S, Boheimier M, et al. Effects of postnatal environmental tobacco smoke on non-nutritive swallowing-breathing coordination in newborn lambs. Respir Physiol Neurobiol. 2013;185:446-53 pubmed publisher
    ..07) during quiet sleep. No effect on respiratory or heart rate (p>0.6), apnea index (p=0.2) or sleep states (p=0.3) was observed. In conclusion, postnatal ETS exposure in lambs had only mild effects on NNS-breathing coordination. ..
  48. Malhotra A, Freston J, Aziz K. Use of pH-impedance testing to evaluate patients with suspected extraesophageal manifestations of gastroesophageal reflux disease. J Clin Gastroenterol. 2008;42:271-8 pubmed publisher
    ..It also distinguishes between reflux due to acid, nonacid, and gas, with consequences for management. ..
  49. Pribuisiene R, Uloza V, Kupcinskas L, Jonaitis L. Perceptual and acoustic characteristics of voice changes in reflux laryngitis patients. J Voice. 2006;20:128-36 pubmed
    ..the multidimensional perceptual, subjective, and instrumental acoustic voice changes in the group of reflux laryngitis (RL) patients...
  50. Carreau A, Patural H, Samson N, Doueik A, Hamon J, Fortier P, et al. Effects of simulated reflux laryngitis on laryngeal chemoreflexes in newborn lambs. J Appl Physiol (1985). 2011;111:400-6 pubmed publisher
    It has been suggested that reflux laryngitis (RL) is involved in apneas-bradycardias of the newborn...
  51. de la Hoz R, Shohet M, Cohen J. Occupational rhinosinusitis and upper airway disease: the world trade center experience. Curr Allergy Asthma Rep. 2010;10:77-83 pubmed publisher
    ..World Trade Center-related UAD is considered an irritant-induced disease but not, in many cases, of acute onset. No data thus far suggest an increased upper airway cancer incidence. ..
  52. Cordero Matía E, de Dios Alcántara Bellón J, Caballero Granado J, De la Torre Lima J, Girón González J, Lama Herrera C, et al. [Clinical and therapeutic management of respiratory tract infections. Consensus document of the Andalusian Infectious Diseases Society and the Andalusian Family and Community Medicine Society]. Enferm Infecc Microbiol Clin. 2007;25:253-62 pubmed
    ..have been: a) pharyngitis; b) sinusitis; c) acute otitis media and otitis externa; d) acute bronchitis, laryngitis, epiglottitis; e) acute exacerbation of chronic bronchitis; and f) respiratory infectious in patients with ..
  53. El Serag H, Lee P, Buchner A, Inadomi J, Gavin M, McCarthy D. Lansoprazole treatment of patients with chronic idiopathic laryngitis: a placebo-controlled trial. Am J Gastroenterol. 2001;96:979-83 pubmed
    ..studies suggested a therapeutic benefit for treating gastroesophageal reflux disease (GERD) among patients with laryngitis. The present study is the first randomized, placebo-controlled, double-blind study of gastric acid suppression ..