renal elimination


Summary: The discharge of substances from the blood supply via the URINARY TRACT.

Top Publications

  1. Ekinci E, Moran J, Thomas M, Cheong K, Clarke S, Chen A, et al. Relationship between urinary sodium excretion over time and mortality in type 2 diabetes. Diabetes Care. 2014;37:e62-3 pubmed publisher
  2. Zhang C, Wang L, Su X, Zhang J, Lin D, Wang W. ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice. Am J Physiol Renal Physiol. 2017;312:F682-F688 pubmed publisher
  3. Gohar E, Kasztan M, Becker B, Speed J, Pollock D. Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis. Am J Physiol Renal Physiol. 2017;313:F361-F369 pubmed publisher
    ..In OVX, activation of medullary P2 receptors promotes ET-dependent natriuresis, suggesting that ovarian hormones may regulate the interplay between the renal ET-1 and P2 signaling systems to facilitate Na+ excretion. ..
  4. Wang L, Song J, Wang S, Buggs J, Chen R, Zhang J, et al. Cross-sex transplantation alters gene expression and enhances inflammatory response in the transplanted kidneys. Am J Physiol Renal Physiol. 2017;313:F326-F338 pubmed publisher
    ..In conclusion, cross-sex-KTX alters gene expression levels and induces inflammatory responses, which might play an important role in long-term graft function. ..
  5. Muhrez K, Largeau B, Emond P, Montigny F, Halimi J, Trouillas P, et al. Single nucleotide polymorphisms of ABCC2 modulate renal secretion of endogenous organic anions. Biochem Pharmacol. 2017;140:124-138 pubmed publisher
    ..This would represent an innovative tool to study the variability of the transport activity of MRP2 under a physiological or pathological condition, especially in pharmacokinetic studies of its substrates. ..
  6. Turpie A, Purdham D, Ciaccia A. Nonvitamin K antagonist oral anticoagulant use in patients with renal impairment. Ther Adv Cardiovasc Dis. 2017;11:243-256 pubmed publisher
    ..To this end, renal function should be assessed in patients on a NOAC, as worsening of renal function may warrant change in the dose of a NOAC or change in oral anticoagulant. ..
  7. Toyoki D, Shibata S, Kuribayashi Okuma E, Xu N, Ishizawa K, Hosoyamada M, et al. Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2. Am J Physiol Renal Physiol. 2017;313:F826-F834 pubmed publisher
    ..These results suggest a previously unrecognized mechanism for the anti-uricosuric effects of insulin and provide novel insights into the renal UA handling in the diabetic state. ..
  8. Storka A, Vcelar B, Klickovic U, Gouya G, Weisshaar S, Aschauer S, et al. Safety, tolerability and pharmacokinetics of liposomal curcumin in healthy humans. Int J Clin Pharmacol Ther. 2015;53:54-65 pubmed publisher
    ..Short-term intravenous dosing of liposomal curcumin appears to be safe up to a dose of 120 mg/m2. Changes in red blood cell morphology may represent a dose limiting sign of toxicity. ..
  9. Rajasekeran H, Lytvyn Y, Božović A, Lovshin J, Diamandis E, Cattran D, et al. Urinary adenosine excretion in type 1 diabetes. Am J Physiol Renal Physiol. 2017;313:F184-F191 pubmed publisher
    ..The potentially protective role of SGLT2i against glomerular hyperfiltration and its mediation by adenosine in diabetes merits further study. ..

More Information


  1. Khemiri R, Côté J, Fetoui H, Bouchard M. Documenting the kinetic time course of lambda-cyhalothrin metabolites in orally exposed volunteers for the interpretation of biomonitoring data. Toxicol Lett. 2017;276:115-121 pubmed publisher
  2. Song J, Wang L, Fan F, Wei J, Zhang J, Lu Y, et al. Role of the Primary Cilia on the Macula Densa and Thick Ascending Limbs in Regulation of Sodium Excretion and Hemodynamics. Hypertension. 2017;70:324-333 pubmed publisher
    ..4±1.6 mm Hg in the KO mice. On the basis of these findings, we concluded that the primary cilia on the macula densa and TAL play an essential role in the control of sodium excretion and blood pressure. ..
  3. Burckhardt B, Henjakovic M, Hagos Y, Burckhardt G. Differential Interaction of Dantrolene, Glafenine, Nalidixic Acid, and Prazosin with Human Organic Anion Transporters 1 and 3. J Pharmacol Exp Ther. 2017;362:450-458 pubmed publisher
    ..At OAT1, more than one binding site must be assumed to explain substrate and drug-dependent stimulation and inhibition of transport activity. ..
  4. Selvarajah V, Mäki Petäjä K, Pedro L, Bruggraber S, Burling K, Goodhart A, et al. Novel Mechanism for Buffering Dietary Salt in Humans: Effects of Salt Loading on Skin Sodium, Vascular Endothelial Growth Factor C, and Blood Pressure. Hypertension. 2017;70:930-937 pubmed publisher
    ..No change was noted in plasma VEGF-C. These findings suggest that the skin may buffer dietary Na+, reducing the hemodynamic consequences of increased salt, and this may be influenced by sex. ..