sex determination processes

Summary

Summary: The mechanisms by which the SEX of an individual's GONADS are fixed.

Top Publications

  1. Radhakrishnan S, Literman R, Mizoguchi B, Valenzuela N. MeDIP-seq and nCpG analyses illuminate sexually dimorphic methylation of gonadal development genes with high historic methylation in turtle hatchlings with temperature-dependent sex determination. Epigenetics Chromatin. 2017;10:28 pubmed publisher
    ..However, further research during embryogenesis will help test this hypothesis and the alternative that instead, most differential methylation observed in hatchlings is the by-product of sexual differentiation and not its cause. ..
  2. Capel B. Vertebrate sex determination: evolutionary plasticity of a fundamental switch. Nat Rev Genet. 2017;18:675-689 pubmed publisher
    ..Ideas emerging from model and non-model organisms that suggest that sex determination operates as an antagonistic network with the emergent property of bistability are discussed. ..
  3. Muyle A, Shearn R, Marais G. The Evolution of Sex Chromosomes and Dosage Compensation in Plants. Genome Biol Evol. 2017;9:627-645 pubmed publisher
    ..Because the difficulty in obtaining sex chromosome sequences is increasingly being overcome by methodological developments, there is great potential for further discovery within the field of plant sex chromosome evolution...
  4. Radhakrishnan S, Literman R, Neuwald J, Severin A, Valenzuela N. Transcriptomic responses to environmental temperature by turtles with temperature-dependent and genotypic sex determination assessed by RNAseq inform the genetic architecture of embryonic gonadal development. PLoS ONE. 2017;12:e0172044 pubmed publisher
    ..In conclusion, while preliminary, our data helps illuminate the regulation and evolution of vertebrate sex determination, and contribute genomic resources to guide further research into this fundamental biological process. ..
  5. Ge C, Ye J, Zhang H, Zhang Y, Sun W, Sang Y, et al. Dmrt1 induces the male pathway in a turtle species with temperature-dependent sex determination. Development. 2017;144:2222-2233 pubmed publisher
  6. Crews D, Bull J. Mode and tempo in environmental sex determination in vertebrates. Semin Cell Dev Biol. 2009;20:251-5 pubmed publisher
  7. Shaffer H, Minx P, Warren D, Shedlock A, Thomson R, Valenzuela N, et al. The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol. 2013;14:R28 pubmed publisher
    ..As these regulatory pathways are analyzed at the functional level, the painted turtle may offer important insights into the management of a number of human health disorders. ..
  8. Sawala A, Gould A. The sex of specific neurons controls female body growth in Drosophila. PLoS Biol. 2017;15:e2002252 pubmed publisher
    ..They also reveal that, even though the sex determination pathways in Drosophila and mammals are different, they both modulate body growth via a combination of tissue-autonomous and nonautonomous inputs...
  9. Strome S, Kelly W, Ercan S, Lieb J. Regulation of the X chromosomes in Caenorhabditis elegans. Cold Spring Harb Perspect Biol. 2014;6: pubmed publisher
    ..elegans X chromosomes and compares these strategies to those used by other organisms to cope with similar X-chromosome dosage differences. ..

More Information

Publications42

  1. Verhulst E, van de Zande L. Double nexus--Doublesex is the connecting element in sex determination. Brief Funct Genomics. 2015;14:396-406 pubmed publisher
  2. Hirst C, Major A, Ayers K, Brown R, Mariette M, Sackton T, et al. Sex Reversal and Comparative Data Undermine the W Chromosome and Support Z-linked DMRT1 as the Regulator of Gonadal Sex Differentiation in Birds. Endocrinology. 2017;158:2970-2987 pubmed publisher
    ..As chicken, zebra finch, and emu exemplify the major evolutionary clades of birds, we propose that Z-linked DMRT1, and not the W sex chromosome, regulates gonadal sex differentiation in birds. ..
  3. Rosenfeld C, Denslow N, Orlando E, Gutierrez Villagomez J, Trudeau V. Neuroendocrine disruption of organizational and activational hormone programming in poikilothermic vertebrates. J Toxicol Environ Health B Crit Rev. 2017;20:276-304 pubmed publisher
    ..By altering such processes, these chemicals may affect reproductive health of an animal and result in compromised populations and ecosystem-level effects. ..
  4. Kagoshima H, Cassata G, Burglin T. A Caenorhabditis elegans homeobox gene expressed in the male tail, a link between pattern formation and sexual dimorphism?. Dev Genes Evol. 1999;209:59-62 pubmed
    ..We have examined the expression of ceh-7 in mutant backgrounds of egl-5 and also mab-5, an Antp/Ubx/Abd-A homologue. We find that ceh-7 is not expressed in egl-5 mutants, but is still expressed in mab-5 mutants. ..
  5. Peterson E, Cline M, Moore E, Roberts N, Roberts R. Genetic sex determination in Astatotilapia calliptera, a prototype species for the Lake Malawi cichlid radiation. Naturwissenschaften. 2017;104:41 pubmed publisher
    ..calliptera, this study provides a foundation for fine mapping of the cichlid sex determination gene on LG7 and evolutionary context regarding the origin and persistence of the LG7 XY across diverse, rapidly evolving lineages. ..
  6. Tang H, Han M. Fatty Acids Regulate Germline Sex Determination through ACS-4-Dependent Myristoylation. Cell. 2017;169:457-469.e13 pubmed publisher
    ..These findings, including a similar role of ACS-4 in a male/female species, uncover a likely conserved mechanism by which FA, an environmental factor, regulates sex determination and reproductive development. ..
  7. Dalal C, Johnson A. How transcription circuits explore alternative architectures while maintaining overall circuit output. Genes Dev. 2017;31:1397-1405 pubmed publisher
    ..Together, these approaches make a strong case that the preservation of gene expression patterns in the wake of extensive rewiring is a general feature of transcription circuit evolution...
  8. Mohamad Ishak N, Nong Q, Matsuura T, Kato Y, Watanabe H. Co-option of the bZIP transcription factor Vrille as the activator of Doublesex1 in environmental sex determination of the crustacean Daphnia magna. PLoS Genet. 2017;13:e1006953 pubmed publisher
    ..These results indicate that Vri was co-opted as a transcriptional activator of Dsx1 in environmental sex determination of D. magna. The data suggests the remarkably plastic nature of gene regulatory network in sex determination...
  9. Namekawa S, Lee J. XY and ZW: is meiotic sex chromosome inactivation the rule in evolution?. PLoS Genet. 2009;5:e1000493 pubmed publisher
  10. Granado Yela C, Balaguer L, Cayuela L, Méndez M. Unusual positional effects on flower sex in an andromonoecious tree: Resource competition, architectural constraints, or inhibition by the apical flower?. Am J Bot. 2017;104:608-615 pubmed publisher
    ..Subapical flowers did not seem to be hormonally suppressed by apical flowers. The study of these unusual positional effects is needed for a general understanding about the functional implications of inflorescence architecture. ..
  11. Goodenough U, Heitman J. Origins of eukaryotic sexual reproduction. Cold Spring Harb Perspect Biol. 2014;6: pubmed publisher
  12. McCaig C, Lin X, Farrell M, Rehain Bell K, Shakes D. Germ cell cysts and simultaneous sperm and oocyte production in a hermaphroditic nematode. Dev Biol. 2017;430:362-373 pubmed publisher
    ..The discovery of simultaneous hermaphroditism and spermatogonia in a lab-cultivatable nematode suggests R. sp. SB347 as a richly informative species for comparative studies of gametogenesis. ..
  13. Gottlieb Y. Check out these males. Heredity (Edinb). 2009;103:1-2 pubmed publisher
  14. Oike A, Kodama M, Yasumasu S, Yamamoto T, Nakamura Y, Ito E, et al. Participation of androgen and its receptor in sex determination of an amphibian species. PLoS ONE. 2017;12:e0178067 pubmed publisher
    ..These results suggest that AR with its androgen ligand functions as a male sex-determinant in the ZW type R. rugosa frogs. ..
  15. Kang Y, Guan G, Hong Y. Insights of sex determination and differentiation from medaka as a teleost model. Yi Chuan. 2017;39:441-454 pubmed publisher
    ..It is anticipated that new techniques will likely be developed in the field of sex manipulations and monosex breeding for fish aquaculture in the future. ..
  16. Miyauchi H, Ohta H, Nagaoka S, Nakaki F, Sasaki K, Hayashi K, et al. Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice. EMBO J. 2017;36:3100-3119 pubmed publisher
    ..Our findings represent a framework for a comprehensive delineation of the sex-determination pathway in mammalian germ cells, including humans. ..
  17. Katsura Y, Kondo H, Ryan J, Harley V, Satta Y. The evolutionary process of mammalian sex determination genes focusing on marsupial SRYs. BMC Evol Biol. 2018;18:3 pubmed publisher
    ..This suggests that the marsupial SRY gene has a function in male determination, but additional experiments are needed to be conclusive. ..
  18. Pucholt P, Hallingbäck H, Berlin S. Allelic incompatibility can explain female biased sex ratios in dioecious plants. BMC Genomics. 2017;18:251 pubmed publisher
    ..Thus, it is possible that the same mechanism generates the female biased sex ratio in natural willow populations. ..
  19. Jetybayev I, Bugrov A, Unal M, Buleu O, Rubtsov N. Molecular cytogenetic analysis reveals the existence of two independent neo-XY sex chromosome systems in Anatolian Pamphagidae grasshoppers. BMC Evol Biol. 2017;17:20 pubmed publisher
  20. . Tree of Sex: a database of sexual systems. Sci Data. 2014;1:140015 pubmed publisher
  21. Latrasse D, Rodriguez Granados N, Veluchamy A, Mariappan K, Bevilacqua C, Crapart N, et al. The quest for epigenetic regulation underlying unisexual flower development in Cucumis melo. Epigenetics Chromatin. 2017;10:22 pubmed publisher
    ..Our results also provide evidence that the sex determination genes recruit histone modifiers to orchestrate unisexual flower development in monoecious species. ..
  22. Rahmoun M, Lavery R, Laurent Chaballier S, Bellora N, Philip G, Rossitto M, et al. In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures. Nucleic Acids Res. 2017;45:7191-7211 pubmed publisher
    ..Starting from the hypothesis that nuclear factors that bind to genomic regions with SCS could functionally interact with SOX9, we identified TRIM28 as a new SOX9 partner in foetal testes. ..
  23. Li P, Liu Y, Luo D, Song C, Cui Z. Two spliced isoforms of the sex-determination gene fruitless in the Chinese mitten crab Eriocheir sinensis. Comp Biochem Physiol B Biochem Mol Biol. 2017;208-209:75-83 pubmed publisher
    ..This is the first report that characterizes two spliced variants of fru in crustaceans and provides basic information for further functional studies of the crab sex-determination mechanism. ..
  24. Podlesnykh A, Brykov V, Kukhlevsky A. Unstable Linkage of Molecular Markers with Sex Determination Gene in Pacific Salmon (Oncorhynchus spp.). J Hered. 2017;108:328-333 pubmed publisher
    ..Also, no linkage was found between noncoding markers and the sdY gene in the same species samples. Possible genetic and physiological mechanisms underlying this discrepancy are discussed. ..
  25. Jeong S, Kim J, Park W, Jeon H, Kim N. SEXCMD: Development and validation of sex marker sequences for whole-exome/genome and RNA sequencing. PLoS ONE. 2017;12:e0184087 pubmed publisher
    ..Another important application of SEXCMD is as a quality control measure to avoid mixing samples before bioinformatics analysis. SEXCMD comprises simple Python and R scripts and is freely available at https://github.com/lovemun/SEXCMD. ..
  26. Qian W, Fan G, Liu D, Zhang H, Wang X, Wu J, et al. Construction of a high-density genetic map and the X/Y sex-determining gene mapping in spinach based on large-scale markers developed by specific-locus amplified fragment sequencing (SLAF-seq). BMC Genomics. 2017;18:276 pubmed publisher
    ..It will also provide an efficient reference for studies on the mechanism of sex determination in other dioecious plants. ..
  27. Moore E, Roberts R. Polygenic sex determination. Curr Biol. 2013;23:R510-2 pubmed publisher
  28. Wu G, Li H, Tey W, Lin C, Chang C. Expression profile of amh/Amh during bi-directional sex change in the protogynous orange-spotted grouper Epinephelus coioides. PLoS ONE. 2017;12:e0185864 pubmed publisher
    ..We suggest that Amh signaling might play dual roles during bi-directional sex change in grouper...
  29. Patau K. X-segregation and heterochromasy in the spider Aranea reaumuri. Heredity (Edinb). 1948;2:77-100 pubmed
  30. Chen J, Niu Y, Li Z, Yang Y, Sun H. Sex allocation in gynodioecious Cyananthus delavayi differs between gender morphs and soil quality. Plant Reprod. 2017;30:107-117 pubmed publisher
    ..Furthermore, some of our findings contradict previous hypotheses, thus adding a new example to the body of research on plant sex allocation and the development of future theories. ..
  31. Lolavar A, Wyneken J. Experimental assessment of the effects of moisture on loggerhead sea turtle hatchling sex ratios. Zoology (Jena). 2017;123:64-70 pubmed publisher
    ..High moisture conditions may produce males through thermal or other mechanisms, highlighting the importance of examining other nest environmental factors on sex determination. ..
  32. Ortega M, Foote D, Nees N, Erdmann J, Bangs C, Rosenfeld C. Karyotype analysis and sex determination in Australian Brush-turkeys (Alectura lathami). PLoS ONE. 2017;12:e0185014 pubmed publisher
  33. Miyajima A, Sunouchi M, Mitsunaga K, Yamakoshi Y, Nakazawa K, Usami M. Sexing of postimplantation rat embryos in stored two-dimensional electrophoresis (2-DE) samples by polymerase chain reaction (PCR) of an Sry sequence. J Toxicol Sci. 2009;34:681-5 pubmed
    ..It was concluded that stored embryonic 2-DE samples could be used for retrospective examination of gender-related effects in proteomic analysis of developmental toxicity. ..