Summary: The L-isomer of Ofloxacin.

Top Publications

  1. Vrany J, Stewart P, Suci P. Comparison of recalcitrance to ciprofloxacin and levofloxacin exhibited by Pseudomonas aeruginosa bofilms displaying rapid-transport characteristics. Antimicrob Agents Chemother. 1997;41:1352-8 pubmed
    ..transform infrared spectroscopy was used to measure transport of the fluoroquinolones (FQs) ciprofloxacin and levofloxacin into Pseudomonas aeruginosa biofilms...
  2. Fu W, Song Z, Zhou L, Xue Y, Ding Y, Suo B, et al. Randomized Clinical Trial: Esomeprazole, Bismuth, Levofloxacin, and Amoxicillin or Cefuroxime as First-Line Eradication Regimens for Helicobacter pylori Infection. Dig Dis Sci. 2017;62:1580-1589 pubmed publisher
    ..were divided into amoxicillin-containing (esomeprazole 20 mg twice/day, amoxicillin 1000 mg twice/day, levofloxacin 500 mg once/day, and bismuth 220 mg twice/day for 14 days) or cefuroxime-containing (esomeprazole 20 mg ..
  3. Furqan S, Paracha S. Frequency of Streptococcus pneumonia and Haemophilus influenza in acute exacerbation of chronic obstructive airway disease and their sensitivity to levofloxacin. J Pak Med Assoc. 2014;64:399-402 pubmed
    ..Haemophilus influenzae in acute exacerbation of chronic obstructive pulmonary disease and their sensitivity to levofloxacin. The cross-sectional study was conducted at the Department of Medicine, AbbasiShaheed Hospital, Karachi, ..
  4. Zdziarski P, Paściak M, Rogala K, Korzeniowska Kowal A, Gamian A. Elizabethkingia miricola as an opportunistic oral pathogen associated with superinfectious complications in humoral immunodeficiency: a case report. BMC Infect Dis. 2017;17:763 pubmed publisher
    ..High-dose immunoglobulin (to maintain IgG > 500 mg/dl) and targeted levofloxacin treatment resulted in immune system reconstitution, oral healing, and eradication of the Elizabethkingia ..
  5. Van Toi P, Pouplin T, Tho N, Phuong P, Chau T, Thuong Thuong N, et al. High-performance liquid chromatography with time-programmed fluorescence detection for the quantification of Levofloxacin in human plasma and cerebrospinal fluid in adults with tuberculous meningitis. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1061-1062:256-262 pubmed publisher
    ..liquid chromatography with time-programmed fluorescence detection was developed and validated to measure levofloxacin in human plasma and cerebrospinal fluid (CSF)...
  6. Ferreira A, Polonini H, Loures da Silva S, Cerqueira de Melo V, de Andrade L, Brandão M. Stability of Alprazolam, Atropine Sulfate, Glutamine, Levofloxacin, Metoprolol Tartrate, Nitrofurantoin, Ondansetron Hydrochloride, Oxandrolone, Pregabaline, and Riboflavin in SyrSpend SF pH4 Oral Suspensions. Int J Pharm Compd. 2017;21:255-263 pubmed
    ..0 mg/mL, atropine sulfate 0.1 mg/mL, glutamine 250.0 mg/mL, levofloxacin 50.0 mg/mL, metoprolol tartrate 10.0 mg/mL, nitrofurantoin 2.0 mg/mL, ondansetron hydrochloride 0...
  7. Zhang M, Chen C, Wang X, Lyu B. [Levofloxacin-based triple therapy versus bismuth-based quadruple therapy in the treatment of Helicobacter pylori as the rescue therapy: a meta analysis]. Zhonghua Nei Ke Za Zhi. 2017;56:368-374 pubmed publisher
    b>Objective: To evaluate the efficacy of levofloxacin-based triple therapy and bismuth-based quadruple therapy in the treatment of Helicobacter pylori (Hp) infection as rescue regimens...
  8. Zhang L, Hu P. Cost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in Chinese elderly patients. Clin Interv Aging. 2017;12:673-678 pubmed publisher
    Pharmacoeconomic cost-effectiveness analysis of two different dosage regimens of levofloxacin in the treatment of acute lower respiratory tract infection in elderly patients...
  9. Branquinho D, Almeida N, Gregorio C, Cabral J, Casela A, Donato M, et al. Levofloxacin or Clarithromycin-based quadruple regimens: what is the best alternative as first-line treatment for Helicobacter pylori eradication in a country with high resistance rates for both antibiotics?. BMC Gastroenterol. 2017;17:31 pubmed publisher
    ..Quadruple Levofloxacin-containing regimens could be an option for first-line treatment, but its efficacy should be evaluated as ..

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  1. El Sadr W, Perlman D, Matts J, Nelson E, Cohn D, Salomon N, et al. Evaluation of an intensive intermittent-induction regimen and duration of short-course treatment for human immunodeficiency virus-related pulmonary tuberculosis. Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) and the AIDS Clinic. Clin Infect Dis. 1998;26:1148-58 pubmed
    This study examined whether adding levofloxacin to a standard four-drug regimen improved the 8-week culture response and compared effectiveness of 9 versus 6 months of intermittent therapy for human immunodeficiency virus-related ..
  2. Katagiri S, Yoshizawa S, Gotoh M, Nakamura I, Ohyashiki K. [Case report; Disseminated Mycobacterium abscessus infection with hemophagocytic syndrome during treatment of chronic lymphocytic leukemia]. Nihon Naika Gakkai Zasshi. 2014;103:734-7 pubmed
  3. Wang J, Lee C, Yu M, Lee M, Lee L, Wang J. Fluoroquinolone use delays tuberculosis treatment despite immediate mycobacteriology study. Eur Respir J. 2015;46:567-70 pubmed publisher
  4. Chien S, Wong F, Fowler C, Callery D Amico S, Williams R, Nayak R, et al. Double-blind evaluation of the safety and pharmacokinetics of multiple oral once-daily 750-milligram and 1-gram doses of levofloxacin in healthy volunteers. Antimicrob Agents Chemother. 1998;42:885-8 pubmed
    The safety and pharmacokinetics of once-daily oral levofloxacin in 16 healthy male volunteers were investigated in a randomized, double-blind, placebo-controlled study...
  5. Liu X, Yang D, Zhou Y, Zhang J, Luo L, Meng S, et al. Electrocatalytic properties of N-doped graphite felt in electro-Fenton process and degradation mechanism of levofloxacin. Chemosphere. 2017;182:306-315 pubmed publisher
    The degradation of antibiotic levofloxacin was investigated by dimensionally stable anode as well as modified cathode using low-cost chemical reagents of hydrazine hydrate and ethanol for electro-Fenton in an undivided cell at pH 3...
  6. Popejoy M, Long J, Huntington J. Analysis of patients with diabetes and complicated intra-abdominal infection or complicated urinary tract infection in phase 3 trials of ceftolozane/tazobactam. BMC Infect Dis. 2017;17:316 pubmed publisher
    ..However, significantly higher composite cure rates were reported with ceftolozane/tazobactam than with levofloxacin in patients without diabetes with cUTI (79.5% vs 69.9%; P = 0.0048)...
  7. Baltch A, Smith R, Ritz W. Inhibitory and bactericidal activities of levofloxacin, ofloxacin, erythromycin, and rifampin used singly and in combination against Legionella pneumophila. Antimicrob Agents Chemother. 1995;39:1661-6 pubmed
    The susceptibilities of 56 Legionella pneumophila isolates (43 clinical and 15 environmental isolates) to levofloxacin, ofloxacin, erythromycin, and rifampin were studied with buffered charcoal yeast extract (BCYE) agar (inoculum, 10(4) ..
  8. Zamani M, Rahbar A, Shokri Shirvani J. Resistance of Helicobacter pylori to furazolidone and levofloxacin: A viewpoint. World J Gastroenterol. 2017;23:6920-6922 pubmed publisher
    ..Additionally, to complete Arslan et al's statement regarding levofloxacin resistance, it should be noted that compound mutations of N87A, A88N and V65I at codon Asn-87 were recently ..
  9. Sippola S, Gronroos J, Tuominen R, Paajanen H, Rautio T, Nordstrom P, et al. Economic evaluation of antibiotic therapy versus appendicectomy for the treatment of uncomplicated acute appendicitis from the APPAC randomized clinical trial. Br J Surg. 2017;104:1355-1361 pubmed publisher
    ..Patients receiving antibiotic therapy for uncomplicated appendicitis incurred lower costs than those who had surgery. ..
  10. Xu K, Ben W, Ling W, Zhang Y, Qu J, Qiang Z. Impact of humic acid on the degradation of levofloxacin by aqueous permanganate: Kinetics and mechanism. Water Res. 2017;123:67-74 pubmed publisher
    b>Levofloxacin (LF) is a frequently detected fluoroquinolone in surface water, and permanganate (MnO4-) is a commonly used oxidant in drinking water treatment...
  11. Shybut T, Puckett E. Triceps Ruptures After Fluoroquinolone Antibiotics: A Report of 2 Cases. Sports Health. 2017;9:474-476 pubmed publisher
    ..These cases highlight a risk of fluoroquinolone-induced tendinopathy to athletes. The sports medicine team should be aware of this risk and consider it when choosing antibiotics to treat athletes. ..
  12. Jia B, Zhang F, Lu Y, Zhang W, Li J, Zhang Y, et al. The clinical features of 590 patients with brucellosis in Xinjiang, China with the emphasis on the treatment of complications. PLoS Negl Trop Dis. 2017;11:e0005577 pubmed publisher
    ..The 3-drug regimen (doxycycline+rifampicin+levofloxacin) for 12 weeks was recommended for these with complications. There were 6 patients died (1...
  13. Fremaux A, Sissia G, Geslin P. In-vitro bacteriostatic activity of levofloxacin and three other fluoroquinolones against penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae. J Antimicrob Chemother. 1999;43 Suppl C:9-14 pubmed
    The purpose of this study was to investigate the in-vitro bacteriostatic activity of levofloxacin in comparison with that of ofloxacin, sparfloxacin and ciprofloxacin against 205 strains of Streptococcus pneumoniae (101 penicillin-..
  14. Akdag Cayli Y, Sahin S, Buttini F, Balducci A, Montanari S, Vural I, et al. Dry powders for the inhalation of ciprofloxacin or levofloxacin combined with a mucolytic agent for cystic fibrosis patients. Drug Dev Ind Pharm. 2017;43:1378-1389 pubmed publisher
    This study aimed to design and characterize an inhalable dry powder of ciprofloxacin or levofloxacin combined with the mucolytics acetylcysteine and dornase alfa for the management of pulmonary infections in patients with cystic fibrosis...
  15. Gao M, Gao J, Du J, Liu Y, Zhang Y, Ma L, et al. Efficacy of ultra-short course chemotherapy for new smear positive drug susceptible pulmonary tuberculosis: study protocol of a multicenter randomized controlled clinical trial. BMC Infect Dis. 2017;17:435 pubmed publisher
    ..5-month fluoroquinolone-containing regimen, which consists of full course of levofloxacin, isoniazid (H), rifampin (R), parazinamid (Z) and ethambutol (E)...
  16. Paily R. Quinolone drug rash in a patient with infectious mononucleosis. J Dermatol. 2000;27:405-6 pubmed
    ..The case of a patient with infectious mononucleosis who was treated with levofloxacin and developed a rash similar to the ampicillin rash is reviewed. The exact mechanism is not understood...
  17. Mah X, Gupta V, Loch S, Ahlenstiel G, Poorten D. Compounded Levofloxacin Triple Therapy is Safe and Effective for Refractory Helicobacter pylori. Int J Pharm Compd. 2017;21:330-333 pubmed
    ..The purpose of this study was to evaluate the efficacy and safety of a compounded levofloxacin triple therapy in clinical practice as a second or third-line salvage regimen for Helicobacter pylori...
  18. Dalhoff A, Schubert S, Vente A. Pharmacodynamics of Finafloxacin, Ciprofloxacin, and Levofloxacin in Serum and Urine against TEM- and SHV-Type Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae Isolates from Patients with Urinary Tract Infections. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    The pharmacodynamics of finafloxacin, ciprofloxacin, and levofloxacin against extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae isolates were compared...
  19. Cai Y, Yang J, Kan Q, Nie X, Wang R, Liang B, et al. Mutant prevention concentration of colistin alone and in combination with levofloxacin or tobramycin against multidrug-resistant Acinetobacter baumannii. Int J Antimicrob Agents. 2012;40:477-8 pubmed publisher
  20. Spangler S, Lin G, Jacobs M, Appelbaum P. Postantibiotic effect and postantibiotic sub-MIC effect of levofloxacin compared to those of ofloxacin, ciprofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci. Antimicrob Agents Chemother. 1998;42:1253-5 pubmed
    ..125, 0.25, and 0.5 times the MIC were determined for levofloxacin, ciprofloxacin, ofloxacin, erythromycin, azithromycin, and clarithromycin against 20 pneumococci...
  21. Grodin L, Conigliaro A, Lee S, Rose M, Sinert R. Comparison of UTI antibiograms stratified by ED patient  disposition. Am J Emerg Med. 2017;35:1269-1275 pubmed publisher
    ..0001) higher in the ED-Only compared to IP-Only groups: ciprofloxacin 80% (76-90%) vs 60% (53-69%), levofloxacin 81% (77-91%) vs 63% (57-72%), nitrofurantoin 75% (70-84%) vs 51% (44-58%), and trimethoprim/sulfamethoxazole 73%..
  22. Hotta F, Eguchi H, Nishimura K, Kogiso M, Ishimaru M, Kusaka S, et al. A super-infection in the cornea caused by Stemphylium, Acremonium, and ?-Streptococcus. Ann Clin Microbiol Antimicrob. 2017;16:11 pubmed publisher
    ..Multiple anti-fungal therapies with levofloxacin ophthalmic solution were administered...
  23. Hsu P, Tsai F, Kao S, Hsu W, Cheng J, Peng N, et al. Ten-Day Quadruple Therapy Comprising Proton Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin is More Effective than Standard Levofloxacin Triple Therapy in the Second-Line Treatment of Helicobacter pylori Infection: A Randomized Controlled Tri. Am J Gastroenterol. 2017;112:1374-1381 pubmed publisher
    ..The objective of this study is to compare the efficacy of esomeprazole-bismuth-tetracycline-levofloxacin therapy (TL quadruple therapy) and esomeprazole-amoxicillin-levofloxacin triple therapy (AL triple therapy) in ..
  24. Chien S, Rogge M, Gisclon L, Curtin C, Wong F, Natarajan J, et al. Pharmacokinetic profile of levofloxacin following once-daily 500-milligram oral or intravenous doses. Antimicrob Agents Chemother. 1997;41:2256-60 pubmed
    The pharmacokinetics of once-daily oral levofloxacin (study A) or intravenous levofloxacin (study B) in 40 healthy male volunteers were investigated in two separate randomized, double-blind, parallel-design, placebo-controlled studies...
  25. Wang A, Li X, Dookhun M, Zhang T, Xie P, Cao Y. A female patient with hypokalaemia-induced J wave syndrome: An unusual case report. Medicine (Baltimore). 2017;96:e8098 pubmed publisher
    ..This case tells us that hypokalaemia might induce J wave and elevated ST segments which should be distinguished from acute myocardial syndrome. ..