sensory deprivation


Summary: The absence or restriction of the usual external sensory stimuli to which the individual responds.

Top Publications

  1. Ren Y, Xie R, Zhou X, Pan M, Lu F. Spontaneous high myopia in one eye will affect the development of form deprivation myopia in the fellow eye. Curr Eye Res. 2011;36:513-21 pubmed publisher
    ..These results indicate that an interaction in refractive development may exist temporarily between two eyes of a highly anisometropic animal if the visual environment has been changed. ..
  2. Krahe T, Guido W. Homeostatic plasticity in the visual thalamus by monocular deprivation. J Neurosci. 2011;31:6842-9 pubmed publisher
    ..Our findings indicate that homeostatic synaptic regulation from MD extends beyond cortical circuitry and shed light on how the brain modulates and integrates activity in the face of altered sensory experience. ..
  3. Sawada M, Kaneko N, Inada H, Wake H, Kato Y, Yanagawa Y, et al. Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb. J Neurosci. 2011;31:11587-96 pubmed publisher
    ..Our results suggest that olfactory-experience-dependent modification of neuronal turnover confers structural plasticity and stability on the olfactory bulb. ..
  4. Mason O, Brady F. The psychotomimetic effects of short-term sensory deprivation. J Nerv Ment Dis. 2009;197:783-5 pubmed publisher
    People experiencing sensory deprivation often report perceptual disturbances such as hallucinations, especially over extended periods of time...
  5. Bastien Dionne P, David L, Parent A, Saghatelyan A. Role of sensory activity on chemospecific populations of interneurons in the adult olfactory bulb. J Comp Neurol. 2010;518:1847-61 pubmed publisher
    ..The present study demonstrates that sensory deprivation diminishes not only the number of newborn cells in the OB, but also reduces the density of granule and ..
  6. Sengpiel F. Experimental models of amblyopia: insights for prevention and treatment. Strabismus. 2011;19:87-90 pubmed publisher
    ..In recent years, animal models of part-time daily monocular deprivation have made an important contribution to the occlusion therapy of amblyopia in children...
  7. House D, Elstrott J, Koh E, Chung J, Feldman D. Parallel regulation of feedforward inhibition and excitation during whisker map plasticity. Neuron. 2011;72:819-31 pubmed publisher
    ..Thus, reduced feedforward inhibition is a covert compensatory process that can maintain excitatory-inhibitory balance during classical deprivation-induced Hebbian map plasticity. ..
  8. Tropea D, Majewska A, Garcia R, Sur M. Structural dynamics of synapses in vivo correlate with functional changes during experience-dependent plasticity in visual cortex. J Neurosci. 2010;30:11086-95 pubmed publisher
  9. Jiang B, Sohya K, Sarihi A, Yanagawa Y, Tsumoto T. Laminar-specific maturation of GABAergic transmission and susceptibility to visual deprivation are related to endocannabinoid sensitivity in mouse visual cortex. J Neurosci. 2010;30:14261-72 pubmed publisher
    ..These results suggest laminar-specific maturation of inhibition and susceptibility to visual deprivation, which may be related to the laminar difference in sensitivity to endocannabinoids. ..

More Information


  1. Yoshihara S, Takahashi H, Nishimura N, Naritsuka H, Shirao T, Hirai H, et al. 5T4 glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb. J Neurosci. 2012;32:2217-26 pubmed publisher
    ..Thus, these results demonstrate that 5T4 glycoprotein contributes in the regulation of activity-dependent dendritic development of interneurons and the formation of functional neural circuitry in the OB. ..
  2. Frasnelli J, Collignon O, Voss P, Lepore F. Crossmodal plasticity in sensory loss. Prog Brain Res. 2011;191:233-49 pubmed publisher
    ..Altogether, the studies reviewed herein illustrate the fascinating plasticity of the brain when coping with sensory deprivation.
  3. Margolis D, Lütcke H, Schulz K, Haiss F, Weber B, Kügler S, et al. Reorganization of cortical population activity imaged throughout long-term sensory deprivation. Nat Neurosci. 2012;15:1539-46 pubmed publisher
    ..Across the baseline period, neurons displayed heterogeneous yet stable responsiveness. During sensory deprivation, responses to trimmed whisker stimulation globally decreased, whereas responses to spared whisker ..
  4. Goel A, Xu L, Snyder K, Song L, Goenaga Vazquez Y, Megill A, et al. Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity. PLoS ONE. 2011;6:e18264 pubmed publisher
    ..Our study provides concrete evidence that a GluR1 dependent mechanism, especially S845 phosphorylation, is a necessary pre-requisite step for in vivo homeostatic synaptic plasticity. ..
  5. Schmid K, Strasberg G, Rayner C, Hartfield P. The effects and interactions of GABAergic and dopaminergic agents in the prevention of form deprivation myopia by brief periods of normal vision. Exp Eye Res. 2013;110:88-95 pubmed publisher
    ..The protective effect of normal vision against form-deprivation is modifiable by both the GABAergic and DAergic pathways. ..
  6. An J, Hsi E, Zhou X, Tao Y, Juo S, Liang C. The FGF2 gene in a myopia animal model and human subjects. Mol Vis. 2012;18:471-8 pubmed
    ..Our data also suggest using normal eyes rather than the fellow eyes as the control eyes when study the form deprivation myopia. ..
  7. Gardiner J, Motta P. Largemouth bass (Micropterus salmoides) switch feeding modalities in response to sensory deprivation. Zoology (Jena). 2012;115:78-83 pubmed publisher
    ..While numerous studies have examined the effects of sensory deprivation on the behaviors leading to prey capture and while it is generally believed that information in the pre-..
  8. Tjiam A, Vukovic E, Asjes Tydeman W, Holtslag G, Loudon S, Sinoo M, et al. How Dutch orthoptists deal with noncompliance with occlusion therapy for amblyopia. Strabismus. 2010;18:146-66 pubmed publisher
    ..We investigated conception, awareness, attitude, and actions to deal with noncompliance among Dutch orthoptists...
  9. Yu H, Majewska A, Sur M. Rapid experience-dependent plasticity of synapse function and structure in ferret visual cortex in vivo. Proc Natl Acad Sci U S A. 2011;108:21235-40 pubmed publisher
  10. He K, Petrus E, Gammon N, Lee H. Distinct sensory requirements for unimodal and cross-modal homeostatic synaptic plasticity. J Neurosci. 2012;32:8469-74 pubmed publisher
    ..In addition, cross-modal changes depend on whisker inputs. Our results demonstrate that unimodal and cross-modal synaptic plasticity occur independently of each other and rely on distinct sensory requirements. ..
  11. Carulli D, Pizzorusso T, Kwok J, Putignano E, Poli A, Forostyak S, et al. Animals lacking link protein have attenuated perineuronal nets and persistent plasticity. Brain. 2010;133:2331-47 pubmed publisher
    ..The organization of chondroitin sulphate proteoglycan into perineuronal nets is therefore the key event in the control of central nervous system plasticity by the extracellular matrix. ..
  12. Angely C, Coppola D. How does long-term odor deprivation affect the olfactory capacity of adult mice?. Behav Brain Funct. 2010;6:26 pubmed publisher
  13. Collignon O, Champoux F, Voss P, Lepore F. Sensory rehabilitation in the plastic brain. Prog Brain Res. 2011;191:211-31 pubmed publisher
    ..rehabilitation avenues in the context of the brain's remarkable ability to reorganize itself following sensory deprivation. Here, deafness and blindness are taken as two illustrative models...
  14. Lambo M, Turrigiano G. Synaptic and intrinsic homeostatic mechanisms cooperate to increase L2/3 pyramidal neuron excitability during a late phase of critical period plasticity. J Neurosci. 2013;33:8810-9 pubmed publisher
  15. Cerri C, Fabbri A, Vannini E, Spolidoro M, Costa M, Maffei L, et al. Activation of Rho GTPases triggers structural remodeling and functional plasticity in the adult rat visual cortex. J Neurosci. 2011;31:15163-72 pubmed publisher
    ..The plasticizing effects of Rho GTPase activation may be exploited to promote brain repair. ..
  16. Nowicka D, Soulsby S, Skangiel Kramska J, Glazewski S. Parvalbumin-containing neurons, perineuronal nets and experience-dependent plasticity in murine barrel cortex. Eur J Neurosci. 2009;30:2053-63 pubmed publisher
    ..These data suggest the involvement of both tested factors in closing the critical period in barrels in an experience-dependent manner. ..
  17. Coppola D. Studies of olfactory system neural plasticity: the contribution of the unilateral naris occlusion technique. Neural Plast. 2012;2012:351752 pubmed publisher
    ..This paper focuses on recent data, new theories, and underappreciated caveats related to the use of this technique in studies of olfactory plasticity. ..
  18. Hess R, Mansouri B, Thompson B. Restoration of binocular vision in amblyopia. Strabismus. 2011;19:110-8 pubmed publisher
    ..To develop a treatment for amblyopia based on re-establishing binocular vision...
  19. Kameyama K, Sohya K, Ebina T, Fukuda A, Yanagawa Y, Tsumoto T. Difference in binocularity and ocular dominance plasticity between GABAergic and excitatory cortical neurons. J Neurosci. 2010;30:1551-9 pubmed publisher
  20. Mao J, Liu S, Qin W, Li F, Wu X, Tan Q. Levodopa inhibits the development of form-deprivation myopia in guinea pigs. Optom Vis Sci. 2010;87:53-60 pubmed publisher
    ..Systemic L-DOPA was partly effective in this guinea pig model and, therefore, is worth testing for effectiveness in progressing human myopes. ..
  21. Maurer D, Hensch T. Amblyopia: background to the special issue on stroke recovery. Dev Psychobiol. 2012;54:224-38 pubmed publisher
    ..Both animal and human studies of amblyopia have recently identified exciting ways to remediate vision in adulthood that bear some similarity to the interventions that have proved successful in promoting recovery from stroke...
  22. Mao Y, Hua T, Pallas S. Competition and convergence between auditory and cross-modal visual inputs to primary auditory cortical areas. J Neurophysiol. 2011;105:1558-73 pubmed publisher
    Sensory neocortex is capable of considerable plasticity after sensory deprivation or damage to input pathways, especially early in development...
  23. Dong F, Zhi Z, Pan M, Xie R, Qin X, Lu R, et al. Inhibition of experimental myopia by a dopamine agonist: different effectiveness between form deprivation and hyperopic defocus in guinea pigs. Mol Vis. 2011;17:2824-34 pubmed
    ..DA signaling may play a more critical role in form deprivation myopia than in defocus-induced myopia, raising a question whether the mechanisms of DA signaling are different under these two types of experimental myopia. ..
  24. Tkatchenko T, Shen Y, Tkatchenko A. Mouse experimental myopia has features of primate myopia. Invest Ophthalmol Vis Sci. 2010;51:1297-303 pubmed publisher
    ..Myopia in mice is associated with elongation of the vitreous chamber of the eye, as in humans and nonhuman primates. ..
  25. McTighe S, Cowell R, Winters B, Bussey T, Saksida L. Paradoxical false memory for objects after brain damage. Science. 2010;330:1408-10 pubmed publisher
    ..This impairment could be rescued with the use of a visual-restriction procedure that reduces interference. Such a pattern of data can be explained in terms of a recent representational-hierarchical view of cognition. ..
  26. Maya Vetencourt J, Tiraboschi E, Spolidoro M, Castren E, Maffei L. Serotonin triggers a transient epigenetic mechanism that reinstates adult visual cortex plasticity in rats. Eur J Neurosci. 2011;33:49-57 pubmed publisher
    ..The data suggest a key role for 5-HT(1A) receptor and BDNF-trkB signalling in driving a transitory epigenetic remodelling of chromatin structure that underlies the reactivation of plasticity in the visual system. ..
  27. Kaneko M, Xie Y, An J, Stryker M, Xu B. Dendritic BDNF synthesis is required for late-phase spine maturation and recovery of cortical responses following sensory deprivation. J Neurosci. 2012;32:4790-802 pubmed publisher
    ..required for spine pruning, late-phase spine maturation, and recovery of cortical responsiveness following sensory deprivation. They also suggest that maturation of dendritic spines is required for the maintenance of cortical ..
  28. Hess R, Thompson B, Black J, Machara G, Zhang P, Bobier W, et al. An iPod treatment of amblyopia: an updated binocular approach. Optometry. 2012;83:87-94 pubmed
    ..This handheld platform provides a convenient and effective platform for implementing the newly proposed binocular treatment of amblyopia in the clinic, home, or elsewhere...
  29. Butko M, Savas J, Friedman B, Delahunty C, EBNER F, Yates J, et al. In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation. Proc Natl Acad Sci U S A. 2013;110:E726-35 pubmed publisher
    ..whisker trimming was used as a model system to test how synaptic proteomes are altered in barrel cortex by sensory deprivation during synaptogenesis...
  30. Bishop H, Zito K. The downs and ups of sensory deprivation: evidence for firing rate homeostasis in vivo. Neuron. 2013;80:247-9 pubmed publisher
    ..Two studies in this issue of Neuron, Hengen et al. (2013) and Keck et al. (2013), provide evidence for firing rate homeostasis in the neocortex of freely behaving rodents. ..
  31. Ashby R, Schaeffel F. The effect of bright light on lens compensation in chicks. Invest Ophthalmol Vis Sci. 2010;51:5247-53 pubmed publisher
    ..The retardation of myopia development by light is partially mediated by dopamine, as the injection of a dopamine antagonist abolishes the protective effect of light, at least in the case of deprivation myopia. ..
  32. Briner A, De Roo M, Dayer A, Muller D, Kiss J, Vutskits L. Bilateral whisker trimming during early postnatal life impairs dendritic spine development in the mouse somatosensory barrel cortex. J Comp Neurol. 2010;518:1711-23 pubmed publisher
    ..They also support an as yet unidentified structural mechanism that might contribute to the layer- and cell-type-specific physiological effects of whisker trimming during the early postnatal period. ..
  33. Restani L, Cerri C, Pietrasanta M, Gianfranceschi L, Maffei L, Caleo M. Functional masking of deprived eye responses by callosal input during ocular dominance plasticity. Neuron. 2009;64:707-18 pubmed publisher
    ..We conclude that callosal inputs play a key role in functional weakening of less active connections during OD plasticity. ..
  34. Ashby R, Megaw P, Morgan I. Changes in retinal alphaB-crystallin (cryab) RNA transcript levels during periods of altered ocular growth in chickens. Exp Eye Res. 2010;90:238-43 pubmed publisher
    ..Given that cryab is a member of the small heat shock protein family, the later increases may reflect the emergence of cell damage related to high myopic pathology in the experimentally enlarged eyes and retina. ..
  35. Morishita H, Miwa J, Heintz N, Hensch T. Lynx1, a cholinergic brake, limits plasticity in adult visual cortex. Science. 2010;330:1238-40 pubmed publisher
    ..The results suggest that modulating the balance between excitatory and inhibitory circuits reactivates visual plasticity and may present a therapeutic target...
  36. Holmes J, Lazar E, Melia B, Astle W, Dagi L, Donahue S, et al. Effect of age on response to amblyopia treatment in children. Arch Ophthalmol. 2011;129:1451-7 pubmed publisher
    ..09). Amblyopia is more responsive to treatment among children younger than 7 years of age. Although the average treatment response is smaller in children 7 to less than 13 years of age, some children show a marked response to treatment. ..
  37. Silingardi D, Scali M, Belluomini G, Pizzorusso T. Epigenetic treatments of adult rats promote recovery from visual acuity deficits induced by long-term monocular deprivation. Eur J Neurosci. 2010;31:2185-92 pubmed publisher
    ..Thus, manipulations of the epigenetic machinery can be used to promote functional recovery from early alterations of sensory input in the adult cortex. ..
  38. Southwell D, Froemke R, Alvarez Buylla A, Stryker M, Gandhi S. Cortical plasticity induced by inhibitory neuron transplantation. Science. 2010;327:1145-8 pubmed publisher
    ..These findings suggest that ocular dominance plasticity is regulated by the execution of a maturational program intrinsic to inhibitory neurons. By inducing plasticity, inhibitory neuron transplantation may facilitate brain repair. ..
  39. Merabet L, Pascual Leone A. Neural reorganization following sensory loss: the opportunity of change. Nat Rev Neurosci. 2010;11:44-52 pubmed publisher
    There is growing evidence that sensory deprivation is associated with crossmodal neuroplastic changes in the brain...
  40. Ghoshal A, TOMARKEN A, EBNER F. Cross-sensory modulation of primary sensory cortex is developmentally regulated by early sensory experience. J Neurosci. 2011;31:2526-36 pubmed publisher
    ..We conclude that there is a modulatory type of cross-sensory auditory influence on normal S1 barrel cortex, which can be enhanced by early postnatal experiences. ..
  41. Iny K, Heynen A, Sklar E, Bear M. Bidirectional modifications of visual acuity induced by monocular deprivation in juvenile and adult rats. J Neurosci. 2006;26:7368-74 pubmed
    ..These findings suggest that the bidirectional changes in visually evoked responses after MD are behaviorally meaningful and that significant plasticity is exhibited well into adulthood. ..
  42. Lee Y, Lee J. Part-time occlusion therapy for anisometropic amblyopia detected in children eight years of age and older. Korean J Ophthalmol. 2006;20:171-6 pubmed
    ..366). The most common component of anisometropia detected after 8 years of age was hyperopia. The part-time occlusion therapy, which had been carried out after school hours, was successful in most cases. ..
  43. Ashby R, McCarthy C, Maleszka R, Megaw P, Morgan I. A muscarinic cholinergic antagonist and a dopamine agonist rapidly increase ZENK mRNA expression in the form-deprived chicken retina. Exp Eye Res. 2007;85:15-22 pubmed
    ..These results suggest that both muscarinic acetylcholine antagonists and dopamine agonists act early in the signal cascade controlling eye growth, possibly within the retina itself. ..
  44. Patwardhan N. Is age relevant for the success of treatment of anisometropic amblyopia?. Indian J Ophthalmol. 2007;55:469-70 pubmed
    ..07). The treatment was successful in 108 (75%) in Group A and in 34 (60.7%) in Group B ( P = 0.07). There was no statistically significant change in the success rate of treatment of anisometropic amblyopia, even beyond 12 years of age. ..
  45. Di Cristo G, Chattopadhyaya B, Kuhlman S, Fu Y, Bélanger M, Wu C, et al. Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity. Nat Neurosci. 2007;10:1569-77 pubmed
    ..The developmental and activity-dependent decline of PSA expression therefore regulates the timing of the maturation of GABAergic inhibition and the onset of ocular dominance plasticity. ..
  46. Sato M, Stryker M. Distinctive features of adult ocular dominance plasticity. J Neurosci. 2008;28:10278-86 pubmed publisher
    ..We propose that adult ocular dominance plasticity arises from compensatory mechanisms that counterbalance the loss of afferent activity caused by visual deprivation. ..
  47. Bracken B, Turrigiano G. Experience-dependent regulation of TrkB isoforms in rodent visual cortex. Dev Neurobiol. 2009;69:267-78 pubmed publisher
    ..Our data indicate that TrkB isoform expression can be selectively regulated by visual experience, and may contribute to experience-dependent cortical plasticity. ..
  48. Pardue M, Faulkner A, Fernandes A, Yin H, Schaeffel F, Williams R, et al. High susceptibility to experimental myopia in a mouse model with a retinal on pathway defect. Invest Ophthalmol Vis Sci. 2008;49:706-12 pubmed publisher
    ..These findings demonstrate an interaction of genetics and environment in refractive development. ..
  49. Heimel J, Hermans J, Sommeijer J, Levelt C. Genetic control of experience-dependent plasticity in the visual cortex. Genes Brain Behav. 2008;7:915-23 pubmed publisher
    ..The expression levels of Stch and to a lesser extent Nrip1 in whole brain correlate with the trait identifying them as novel candidate plasticity genes. ..
  50. McCarthy C, Megaw P, Devadas M, Morgan I. Dopaminergic agents affect the ability of brief periods of normal vision to prevent form-deprivation myopia. Exp Eye Res. 2007;84:100-7 pubmed
    ..These responses are mediated by D2 receptors, suggesting that the protective effect of normal vision against form-deprivation is mediated through the stimulation of dopamine release and activation of D2-dopamine receptors. ..
  51. Levi D, Li R. Perceptual learning as a potential treatment for amblyopia: a mini-review. Vision Res. 2009;49:2535-49 pubmed publisher
    ..The success of PL raises the question of whether it should become a standard part of the armamentarium for the clinical treatment of amblyopia, and suggests several important principles for effective perceptual learning in amblyopia. ..
  52. Kim H, Puche A, Margolis F. Odorant deprivation reversibly modulates transsynaptic changes in the NR2B-mediated CREB pathway in mouse piriform cortex. J Neurosci. 2006;26:9548-59 pubmed
    ..In summary, the present study provides an initial characterization of the molecular mechanisms associated with odor stimulation on second order neuronal plasticity and phenotype in the olfactory system. ..
  53. Smith E, Huang J, Hung L, Blasdel T, Humbird T, Bockhorst K. Hemiretinal form deprivation: evidence for local control of eye growth and refractive development in infant monkeys. Invest Ophthalmol Vis Sci. 2009;50:5057-69 pubmed publisher
    ..To determine whether refractive development in primates is mediated by local retinal mechanisms, the authors examined the effects of hemiretinal form deprivation on ocular growth and the pattern of peripheral refractions in rhesus monkeys...