spatial memory


Summary: Memory related to spatial information.

Top Publications

  1. McManus M, D Amour S, Harris L. Using optic flow in the far peripheral field. J Vis. 2017;17:3 pubmed publisher
    Self-motion information can be used to update spatial memory of location through an estimate of a change in position. Viewing optic flow alone can create Illusory self-motion or "vection...
  2. Zhao T, Kim K, Shin K, Park H, Kim H, Lee K, et al. Gypenosides ameliorate memory deficits in MPTP-lesioned mouse model of Parkinson's disease treated with L-DOPA. BMC Complement Altern Med. 2017;17:449 pubmed publisher
    ..MPTP-lesioned mice exhibited deficits associated with habit learning and spatial memory, which were further aggravated by treatment with L-DOPA (25 mg/kg)...
  3. Lester A, Moffat S, Wiener J, Barnes C, Wolbers T. The Aging Navigational System. Neuron. 2017;95:1019-1035 pubmed publisher
    ..The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders. ..
  4. Zancada Menendez C, Alvarez Suarez P, Sampedro Piquero P, Cuesta M, Begega A. Requiring collaboration: Hippocampal-prefrontal networks needed in spatial working memory and ageing. A multivariate analysis approach. Neurobiol Learn Mem. 2017;140:33-42 pubmed publisher
    ..This response could be due to a higher requirement of the executive control in a complex spatial memory task in older animals.
  5. Zhu G, Tao L, Wang R, Xue Y, Wang X, Yang S, et al. Endoplasmic reticulum stress mediates distinct impacts of sevoflurane on different subfields of immature hippocampus. J Neurochem. 2017;142:272-285 pubmed publisher
    ..The negative effects, such as inducing cell death and damaging spatial memory, of sevoflurane on neurodevelopment have raised increasing concerns in recent years...
  6. Saito S, Yamamoto Y, Maki T, Hattori Y, Ito H, Mizuno K, et al. Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy. Acta Neuropathol Commun. 2017;5:26 pubmed publisher
    ..In conclusion, taxifolin prevents amyloid-β oligomer assembly and fully sustains cognitive and cerebrovascular function in a CAA model mice. Taxifolin thus appears a promising therapeutic approach for CAA. ..
  7. Bilkei Gorzo A, Albayram O, Draffehn A, Michel K, Piyanova A, Oppenheimer H, et al. A chronic low dose of ?9-tetrahydrocannabinol (THC) restores cognitive function in old mice. Nat Med. 2017;23:782-787 pubmed publisher
    ..Thus, restoration of CB1 signaling in old individuals could be an effective strategy to treat age-related cognitive impairments. ..
  8. Bolkan S, Stujenske J, Parnaudeau S, Spellman T, Rauffenbart C, Abbas A, et al. Thalamic projections sustain prefrontal activity during working memory maintenance. Nat Neurosci. 2017;20:987-996 pubmed publisher
    ..These findings indicate a role for MD in sustaining prefrontal activity during working memory maintenance. Consistent with this idea, we found that enhancing MD excitability was sufficient to enhance task performance. ..
  9. Royea J, Zhang L, Tong X, Hamel E. Angiotensin IV Receptors Mediate the Cognitive and Cerebrovascular Benefits of Losartan in a Mouse Model of Alzheimer's Disease. J Neurosci. 2017;37:5562-5573 pubmed publisher
    ..AT4R-mediated effects were independent from changes in blood pressure, amyloidosis, and oxidative stress. Overall, our results implicate the angiotensin IV/AT4R cascade as a promising candidate for AD intervention. ..

More Information


  1. Roux L, Hu B, Eichler R, Stark E, Buzsaki G. Sharp wave ripples during learning stabilize the hippocampal spatial map. Nat Neurosci. 2017;20:845-853 pubmed publisher
    ..SPW-R silencing did not impact the firing rates or proportions of place cells. These results suggest that interference with SPW-R-associated activity during learning prevents stabilization and refinement of hippocampal maps. ..
  2. Zhao Y, He L, Zhang Y, Zhao J, Liu Z, Xing F, et al. Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice. J Steroid Biochem Mol Biol. 2017;174:96-113 pubmed publisher
    ..that the ER? and ER? antagonists induced a disruption in actin polymerization and an impairment of spatial memory, which were rescued by activation of mTORC2...
  3. Rawdon C, Murphy J, Blanchard M, Kelleher I, Clarke M, Kavanagh F, et al. Reduced P300 amplitude during retrieval on a spatial working memory task in a community sample of adolescents who report psychotic symptoms. BMC Psychiatry. 2013;13:125 pubmed publisher
    ..These results identify neural correlates of neurocognitive dysfunction associated with population level psychotic symptoms and provide insights into ERP abnormalities associated with the extended psychosis phenotype. ..
  4. del Pino I, Brotons Mas J, Marques Smith A, Marighetto A, Frick A, Marin O, et al. Abnormal wiring of CCK+ basket cells disrupts spatial information coding. Nat Neurosci. 2017;20:784-792 pubmed publisher
    ..These results suggest that normal integration of CCK+ basket cells in cortical networks is key to support spatial coding in the hippocampus. ..
  5. Castellano J, Mosher K, Abbey R, McBride A, James M, Berdnik D, et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature. 2017;544:488-492 pubmed publisher
    ..We find that systemic pools of TIMP2 are necessary for spatial memory in young mice, while treatment of brain slices with TIMP2 antibody prevents long-term potentiation, arguing ..
  6. Niccolini F, Wilson H, Pagano G, Coello C, Mehta M, Searle G, et al. Loss of phosphodiesterase 4 in Parkinson disease: Relevance to cognitive deficits. Neurology. 2017;89:586-593 pubmed publisher
    ..Our findings demonstrate loss of PDE4 expression in the striato-thalamo-cortical circuit, which is associated with deficits of spatial working memory in patients with PD. ..
  7. Ionita R, Postu P, Beppe G, Mihasan M, Petre B, Hancianu M, et al. Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine. Behav Brain Funct. 2017;13:5 pubmed publisher
    ..These results suggest that the aqueous extract ameliorates scopolamine-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.
  8. Jeong D, Lee J, Chang W, Chang J. Identifying the appropriate time for deep brain stimulation to achieve spatial memory improvement on the Morris water maze. BMC Neurosci. 2017;18:29 pubmed publisher
    ..Our previous study suggested that spatial memory improvement by medial septum (MS)-DBS may be associated with cholinergic regulation and neurogenesis...
  9. Dinel A, Joffre C, Trifilieff P, Aubert A, Foury A, Le Ruyet P, et al. Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood. J Neuroinflammation. 2014;11:155 pubmed publisher
    ..In this study, we examined whether an early-life inflammatory challenge could alter emotional behaviors and spatial memory at adolescence and adulthood and whether stress axis activity, inflammatory response and neurogenesis were ..
  10. Rahman A, Lamberty Y, Schenker E, Cella M, Languille S, Bordet R, et al. Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus). PLoS ONE. 2017;12:e0184822 pubmed publisher
    ..In particular, spatial memory impairment was evaluated using a circular platform task after 8 h of total SD...
  11. Bruder G, Lubas P, Steinicke F. Cognitive Resource Demands of Redirected Walking. IEEE Trans Vis Comput Graph. 2015;21:539-44 pubmed publisher
    ..We discuss the implications and provide guidelines for using redirected walking in virtual reality laboratories. ..
  12. Johansson J, Woodling N, Wang Q, Panchal M, Liang X, Trueba Saiz A, et al. Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models. J Clin Invest. 2015;125:350-64 pubmed publisher
  13. Nguyen V, Starzyk J, Goh W, Jachyra D. Neural network structure for spatio-temporal long-term memory. IEEE Trans Neural Netw Learn Syst. 2012;23:971-83 pubmed publisher
    ..Results show that our LTM model is robust to different types of distortions. Second, our LTM model outperforms other sequential processing models in a classification task for the ASL dataset. ..
  14. Anastácio J, Netto C, Castro C, Sanches E, Ferreira D, Noschang C, et al. Resveratrol treatment has neuroprotective effects and prevents cognitive impairment after chronic cerebral hypoperfusion. Neurol Res. 2014;36:627-33 pubmed publisher
  15. Shanmugasundaram B, Aher Y, Aradska J, Ilić M, Daba Feyissa D, Kalaba P, et al. R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity. PLoS ONE. 2017;12:e0179675 pubmed publisher
    ..Hence we studied its effect in a spatial memory paradigm and its possible effects on dentate gyrus long-term potentiation (DG-LTP)...
  16. Fang X, Li S, Han Q, Zhao Y, Gao J, Yan J, et al. Overexpression cdc42 attenuates isoflurane-induced neurotoxicity in developmental brain of rats. Biochem Biophys Res Commun. 2017;490:719-725 pubmed publisher
    ..Cdc42 over-expression could reverse neurotoxicity and improve cognitive impairment induced by isoflurane. ..
  17. Chaisawang P, Sirichoat A, Chaijaroonkhanarak W, Pannangrong W, Sripanidkulchai B, Wigmore P, et al. Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy. PLoS ONE. 2017;12:e0180650 pubmed publisher
    ..These data demonstrate that AA can prevent the spatial working memory and hippocampal neurogenesis impairments caused by 5-FU chemotherapy. ..
  18. Zhang L, Chen G, Chen J, He X, Hu X. [Mechanisms of histamine ameliorating memory impairment induced by pentylenetetrazole-kindling epilepsy in rats]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017;46:1-6 pubmed
    b>Objective: To investigate the effects of neuronal histamine on spatial memory acquisition impairment in rats with pentylenetetrazole-kindling epilepsy, and to explore its mechanisms...
  19. Mamad O, Stumpp L, McNamara H, Ramakrishnan C, Deisseroth K, Reilly R, et al. Place field assembly distribution encodes preferred locations. PLoS Biol. 2017;15:e2002365 pubmed publisher
  20. Woitke F, Ceanga M, Rudolph M, Niv F, Witte O, Redecker C, et al. Adult hippocampal neurogenesis poststroke: More new granule cells but aberrant morphology and impaired spatial memory. PLoS ONE. 2017;12:e0183463 pubmed publisher
    ..In conclusion, ischemic insults cause hippocampal-dependent memory deficits which are associated with aberrant neurogenesis in the dentate gyrus indicating ischemia-induced maladaptive plasticity in the hippocampus. ..