- Cetaceans on a molecular fast track to ultrasonic hearing
School of Life Sciences, East China Normal University, Shanghai, China
Curr Biol 20:1834-9. 2010
..Echolocation in toothed whales demands exceptional high-frequency hearing , and both echolocation and ultrasonic hearing have also evolved independently in bats [4, 5]...
- High-frequency tinnitus without hearing loss does not mean absence of deafferentation
Department of Psychology, University of Konstanz, Germany
Hear Res 222:108-14. 2006
..The absence of audiometrically detectable hearing loss however poses a challenge to this rather generalizing assumption...
- Parallel signatures of sequence evolution among hearing genes in echolocating mammals: an emerging model of genetic convergence
K T J Davies
School of Biological and Chemical Sciences, Queen Mary University of London, London, UK
Heredity (Edinb) 108:480-9. 2012
..in the Prestin gene among some bats and cetaceans suggest that parallel adaptations for high-frequency hearing have taken place during the evolution of echolocation...
- Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma
Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
Neuron 77:58-69. 2013
b>Hearing loss due to damage to auditory hair cells is normally irreversible because mammalian hair cells do not regenerate...
- The functional significance of mu rhythms: translating "seeing" and "hearing" into "doing"
Jaime A Pineda
Department of Cognitive Science and Neuroscience, University of California, San Diego, La Jolla, CA 92037 0515, USA
Brain Res Brain Res Rev 50:57-68. 2005
..processing function that links perception and action-specifically, the transformation of "seeing" and "hearing" into "doing...
- Drosophila auditory organ genes and genetic hearing defects
Pingkalai R Senthilan
Department of Cellular Neurobiology, University of Gottingen, Julia Lermontowa Weg 3, 37077 Gottingen, Germany
Cell 150:1042-54. 2012
..Only four of these genes had previously been associated with fly hearing, yet one in five of the genes that we identified has a human cognate that is implicated in hearing disorders...
- The hearing gene Prestin unites echolocating bats and whales
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Curr Biol 20:R55-6. 2010
..substantially in many aspects , we here report the surprising finding that the bottlenose dolphin, a toothed whale, is clustered with microbats in the gene tree constructed using protein sequences encoded by the hearing gene Prestin.
- The LINC complex is essential for hearing
Henning F Horn
Institute of Medical Biology, A STAR, Singapore
J Clin Invest 123:740-50. 2013
Hereditary hearing loss is the most common sensory deficit. We determined that progressive high-frequency hearing loss in 2 families of Iraqi Jewish ancestry was due to homozygosity for the protein truncating mutation SYNE4 c.228delAT...
- Precise inhibition is essential for microsecond interaural time difference coding
Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany
Nature 417:543-7. 2002
..A computer model, simulating the response of a coincidence-detector neuron with bilateral excitatory inputs and a temporally precise contralateral inhibitory input, supports this conclusion...
- The neural basis of Drosophila gravity-sensing and hearing
Sensory Systems Laboratory, Institute of Zoology, University of Cologne, 50923 Cologne, Germany
Nature 458:165-71. 2009
..Here we focus on two of the remaining and less understood prime sensory modalities: graviception and hearing. We show that the fly has implemented both sensory modalities into a single system, Johnston's organ, which ..
- Review series: The cell biology of hearing
Department of Cell Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
J Cell Biol 190:9-20. 2010
..The study of genes that are linked to deafness has provided insights into the cell biological mechanisms that control hair cell development and their function as mechanosensors...
- Key functions for gap junctions in skin and hearing
Claire A Scott
Centre for Cutaneous Research, The Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
Biochem J 438:245-54. 2011
..3 and Cx31 which lead to skin disease and deafness. Functional studies with Cx proteins have given insights into disease-associated mechanisms and non-gap junctional roles for Cx proteins...
- Effects of hearing aid amplification and stimulus intensity on cortical auditory evoked potentials
Curtis J Billings
Department of Speech and Hearing Sciences, University of Washington, Seattle, WA 98105, USA
Audiol Neurootol 12:234-46. 2007
b>Hearing aid amplification can be used as a model for studying the effects of auditory stimulation on the central auditory system (CAS)...
- The hearing gene Prestin reunites echolocating bats
School of Life Science, East China Normal University, Shanghai 200062, China
Proc Natl Acad Sci U S A 105:13959-64. 2008
..Echolocating bats use ultrasound for orientation and hunting and possess the highest frequency hearing of all mammals...
- Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography
Simon S Gao
Department of Otolaryngology Head and Neck Surgery, Stanford University, 801 Welch Road, Stanford, CA 94305, USA
Opt Express 19:15415-28. 2011
Human hearing loss often occurs as a result of damage or malformations to the functional soft tissues within the cochlea, but these changes are not appreciable with current medical imaging modalities...
- Effects of round window dexamethasone on residual hearing in a Guinea pig model of cochlear implantation
David P James
Department of Otolaryngology, University of Melbourne, Parkville, Australia
Audiol Neurootol 13:86-96. 2008
..Animals that did not receive beads acted as controls. Pure-tone auditory brainstem response thresholds were estimated before and after electrode insertion, and 1 and 4 weeks later. Selected cochlear histology was performed...
- Electrical stimulation of the midbrain for hearing restoration: insight into the functional organization of the human central auditory system
Hubert H Lim
Otorhinolaryngology Department, Hannover Medical University, 30625 Hannover, Germany
J Neurosci 27:13541-51. 2007
The cochlear implant can restore speech perception in patients with sensorineural hearing loss. However, it is ineffective for those without an implantable cochlea or a functional auditory nerve...
- Directional hearing by linear summation of binaural inputs at the medial superior olive
Marcel van der Heijden
Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
Neuron 78:936-48. 2013
..The inputs from both ears sum linearly, whereas spike probability depends nonlinearly on the size of synaptic inputs. This simple coincidence detection scheme thus makes accurate sound localization possible...
- Seeing and hearing speech excites the motor system involved in speech production
K E Watkins
Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
Neuropsychologia 41:989-94. 2003
..These results provide evidence that both auditory and visual speech perception facilitate the excitability of the motor system involved in speech production...
- Baby hands that move to the rhythm of language: hearing babies acquiring sign languages babble silently on the hands
Laura Ann Petitto
Department of Psychological and Brain Sciences and Department of Education, Raven House, Dartmouth College, Hanover, NH 03755, USA
Cognition 93:43-73. 2004
..Two groups of hearing babies were studied over time (ages 6, 10, and 12 months), equal in all developmental respects except for the ..
- The remarkable cochlear amplifier
Department of Neuroscience, Physiology and Pharmacology and UCL Ear Institute, Gower Street, London WC1E 6BT, UK
Hear Res 266:1-17. 2010
..These experiments are presently lacking but if successfully performed would have an enormous impact on our understanding of the cochlear amplifier...
- Hearing visual motion in depth
Department of Psychology, Tokyo Metropolitan University, 1 1, Minami Osawa, Hachioji shi, Tokyo 192 0397, Japan
Nature 416:172-4. 2002
..The results provide psychophysical evidence that, for processing of motion in depth, the auditory system responds to both auditory changing intensity and visual motion in depth...
- A TRPV family ion channel required for hearing in Drosophila
Department of Genetics, Hanwha Chemical Co R and D Center, Sinsung dong, Yusung Gu, Daejeon 305 345, Korea
Nature 424:81-4. 2003
..Antennal sound-evoked potentials are completely absent in mutants lacking Nan, showing that it is an essential component of the chordotonal mechanotransducer...
- Structural determinants of cadherin-23 function in hearing and deafness
Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
Neuron 66:85-100. 2010
..The structures define an uncharacterized cadherin family and, with simulations, suggest mechanisms underlying inherited deafness and how cadherin-23 may bind with itself and with protocadherin-15 to form the tip link...
- Hearing lips and seeing voices: how cortical areas supporting speech production mediate audiovisual speech perception
Jeremy I Skipper
Department of Neurology, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
Cereb Cortex 17:2387-99. 2007
- The sensory and motor roles of auditory hair cells
Department of Physiology, University of Wisconsin Medical School, 185 Medical Sciences Building, 1300 University Avenue, Madison, Wisconsin 53706, USA
Nat Rev Neurosci 7:19-29. 2006
..Both motor mechanisms are probably needed to provide the high sensitivity and frequency discrimination of the mammalian cochlea...
- Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28
Developmental Genetics Laboratory of Tsinghua University, School of Life Sciences, Tsinghua University, Beijing 100084, China
Hum Mol Genet 20:3213-26. 2011
Congenital and progressive hearing impairment is a common distressing disease...
- ATP8B1 is essential for maintaining normal hearing
Janneke M Stapelbroek
Department of Pediatric Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands
Proc Natl Acad Sci U S A 106:9709-14. 2009
..Because patients sometimes report reduced hearing capability, we investigated the role of ATP8B1 in auditory function...
- Auditory analysis of xeroderma pigmentosum 1971-2012: hearing function, sun sensitivity and DNA repair predict neurological degeneration
Mariam B Totonchy
Dermatology Branch, National Cancer Institute, Bethesda, MD 20892, USA
Brain 136:194-208. 2013
To assess the role of DNA repair in maintenance of hearing function and neurological integrity, we examined hearing status, neurological function, DNA repair complementation group and history of acute burning on minimal sun exposure in ..
- Hearing screening in a neonatal intensive care unit
Gisele M L Lima
Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP, Brazil
J Pediatr (Rio J) 82:110-4. 2006
Investigate the prevalence of hearing impairment in newborns hospitalized at the Intensive and Intermediate Care Unit at the Women's Comprehensive Health Center Neonatology Service (UNICAMP) and associated risk factors.
- A new electrode for residual hearing preservation in cochlear implantation: first clinical results
Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria
Acta Otolaryngol 129:372-9. 2009
A so far unattained high rate (100%) of residual hearing preservation in cochlear implantation for electric-acoustic stimulation could be achieved using sophisticated surgical techniques in combination with the MedEl Flex EAS electrode.
- Distinct roles of TRP channels in auditory transduction and amplification in Drosophila
Brendan P Lehnert
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
Neuron 77:115-28. 2013
..Thus, transduction and active amplification are genetically separable processes in Drosophila hearing.
- Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane
Ian J Russell
School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
Nat Neurosci 10:215-23. 2007
..Although these mice have a low-frequency hearing loss, basilar-membrane and neural tuning are both significantly enhanced in the high-frequency regions of the ..
- Physical basis of two-tone interference in hearing
Cavendish Laboratory, Madingley Road, Cambridge CB3 0HE, United Kingdom
Proc Natl Acad Sci U S A 98:9080-5. 2001
..Our analysis provides a general framework for examining the relation between the physical nature of the peripheral detection apparatus and psychophysical phenomena such as the sensation of dissonance and auditory illusions...
- TRPA channels distinguish gravity sensing from hearing in Johnston's organ
Neuroscience Graduate Program, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 106:13606-11. 2009
..mutating specific TRP genes produced distinct phenotypes, disrupting negative geotaxis (painless and pyrexia), hearing (nompC), or both (nanchung and inactive)...
- An ENU-induced mutation of Cdh23 causes congenital hearing loss, but no vestibular dysfunction, in mice
Shehnaaz S M Manji
Genetic Hearing Research Laboratory, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
Am J Pathol 179:903-14. 2011
..in the human cadherin 23 (CDH23) gene cause deafness, neurosensory, autosomal recessive 12 (DFNB12) nonsyndromic hearing loss or Usher syndrome, type 1D (characterized by hearing impairment, vestibular dysfunction, and visual ..
- Matching sender and receiver: poikilothermy and frequency tuning in a tree cricket
School of Biological Sciences, Woodland Road, University of Bristol, Bristol BS8 1UG, UK
J Exp Biol 214:2569-78. 2011
- Maturation of glycinergic inhibition in the gerbil medial superior olive after hearing onset
Anna K Magnusson
Division of Neurobiology, Department Biologie II, Ludwig Maximilians University, Martinsried, Germany
J Physiol 568:497-512. 2005
..was shown that the glycinergic input to the MSO undergoes an experience-dependent structural reorganization after hearing onset...
- Recognition of speech in noise with new hearing instrument compression release settings requires explicit cognitive storage and processing capacity
Department of Behavioural Sciences and Learning, Linkoping University, Sweden
J Am Acad Audiol 18:618-31. 2007
..capacity predicts the ability to benefit from specific compression release settings in non-linear digital hearing instruments...
- Relations between frequency selectivity, temporal fine-structure processing, and speech reception in impaired hearing
Centre for Applied Hearing Research, Department of Electrical Engineering, Technical University of Denmark, Building 352, Orsteds Plads, 2800 Kgs Lyngby, Denmark
J Acoust Soc Am 125:3328-45. 2009
Frequency selectivity, temporal fine-structure (TFS) processing, and speech reception were assessed for six normal-hearing (NH) listeners, ten sensorineurally hearing-impaired (HI) listeners with similar high-frequency losses, and two ..
- Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing
Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
J Physiol 558:659-69. 2004
Mechanosensitive cation channels are thought to be crucial for different aspects of mechanoperception, such as hearing and touch sensation. In the nematode C...
- Rethinking sound detection by fishes
Arthur N Popper
Department of Biology and Center for Comparative and Evolutionary Biology of Hearing, University of Maryland, College Park, MD 20742, USA
Hear Res 273:25-36. 2011
In this paper we reconsider the designation of fishes as being either "hearing specialists" or "hearing generalists," and recommend dropping the terms...
- Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways
Medical Genetics, Department of Reproductive Sciences and Development, IRCCS Burlo Garofolo, University of Trieste, Italy
J Med Genet 48:369-74. 2011
b>Hearing is a complex trait, but until now only a few genes are known to contribute to variability of this process...
- The corpus callosum in dichotic listening studies of hemispheric asymmetry: a review of clinical and experimental evidence
Department of Biological and Medical Psychology, Cognitive Neuroscience Group, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
Neurosci Biobehav Rev 32:1044-54. 2008
..The review has also revealed how inter-individual variability in callosal fiber structure affects both bottom-up and top-down performance on the dichotic listening task...
- Audition in sciaenid fishes with different swim bladder-inner ear configurations
John U Ramcharitar
Department of Biology and Neuroscience and Cognitive Science Program, University of Maryland, College Park, Maryland 20742, USA
J Acoust Soc Am 119:439-43. 2006
We investigated how morphological differences in the auditory periphery of teleost fishes may relate to hearing capabilities...
- Otoacoustic emissions in a hearing conservation program: general applicability in longitudinal monitoring and the relation to changes in pure-tone thresholds
Hiske W Helleman
Clinical and Experimental Audiology, ENT Department, Academic Medical Centre, Amsterdam, The Netherlands
Int J Audiol 49:410-9. 2010
The hearing status of workers (N = 233) in a printing office was assessed twice within seventeen months by pure-tone audiometry and otoacoustic emissions (OAEs)...
- Hearing syllables by seeing visual stimuli
University of Zurich, Institute of Psychology, Division of Neuropsychology, Treichlerstr 10, Switzerland
Eur J Neurosci 19:2603-8. 2004
..To overcome the detrimental effects of scanner noise, one group of subjects was trained to vividly imagine hearing a syllable while a flashlight was presented. A control group did not receive this training...
- The role of temporal fine structure processing in pitch perception, masking, and speech perception for normal-hearing and hearing-impaired people
Brian C J Moore
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
J Assoc Res Otolaryngol 9:399-406. 2008
..Evidence is reviewed suggesting that cochlear hearing loss reduces the ability to use TFS cues...
- Lefties get it "right" when hearing tool sounds
James W Lewis
Department of Physiology and Phamacology, West Virginia University, WV 26506 9229, USA
J Cogn Neurosci 18:1314-30. 2006
..In right-handers, we previously reported that hearing hand-manipulated tool sounds preferentially activates a left hemisphere network of motor-related brain regions ..
- Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition
Byung Yoon Choi
Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, USA
J Clin Invest 121:4516-25. 2011
Mutations in human SLC26A4 are a common cause of hearing loss associated with enlarged vestibular aqueducts (EVA)...
- Relationship between swim bladder morphology and hearing abilities--a case study on Asian and African cichlids
Department of Behavioral Biology, University of Vienna, Vienna, Austria
PLoS ONE 7:e42292. 2012
..A few comparative studies have shown that these morphological specializations may enhance hearing abilities...
- Prestin's role in cochlear frequency tuning and transmission of mechanical responses to neural excitation
Marcia M Mellado Lagarde
School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
Curr Biol 18:200-2. 2008
..Prestin is crucial for defining sharp and sensitive cochlear frequency tuning by reducing the sensitivity of the low-frequency tail of the tuning curve, although this necessitates a cochlear amplifier to determine the narrowly tuned tip...
- The case for early identification of hearing loss in children. Auditory system development, experimental auditory deprivation, and development of speech perception and hearing
Y S Sininger
Children s Auditory Research and Evaluation Center, University of California Davis Medical Center, USA
Pediatr Clin North Am 46:1-14. 1999
..Although it is not visible to observers, infants with hearing are learning to process speech and understand language and are quite linguistically sophisticated by 1 year of ..
- Normal hearing is not enough to guarantee robust encoding of suprathreshold features important in everyday communication
Department of Biomedical Engineering, Boston University Hearing Research Center, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 108:15516-21. 2011
Normal hearing" is typically defined by threshold audibility, even though everyday communication relies on extracting key features of easily audible sound, not on sound detection...
- Reading, hearing, and the planum temporale
Bradley R Buchsbaum
Department of Health and Human Services, Unit on Integrative Neuroimaging, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1365, USA
Neuroimage 24:444-54. 2005
..Moreover, increasing the smoothing window to 10 mm obliterates activation in the PT, suggesting that failure to find PT activation in past studies may relate to this factor...
- Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila
Biology Department, University of Virginia, Charlottesville, Virginia 22904, USA
J Neurosci 24:9059-66. 2004
b>Hearing in Drosophila depends on the transduction of antennal vibration into receptor potentials by ciliated sensory neurons in Johnston's organ, the antennal chordotonal organ...
- Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier
M Charles Liberman
Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Nature 419:300-4. 2002
b>Hearing sensitivity in mammals is enhanced by more than 40 dB (that is, 100-fold) by mechanical amplification thought to be generated by one class of cochlear sensory cells, the outer hair cells...
- Functional groups in the avian auditory system
Sarah M N Woolley
Department of Psychology, Columbia University, New York, New York 10027, USA
J Neurosci 29:2780-93. 2009
..Comparing STRFs in midbrain and forebrain neurons suggested that both inheritance and emergence of tuning properties occur as information ascends the auditory processing stream...
- Area Spt in the human planum temporale supports sensory-motor integration for speech processing
Center for Cognitive Neuroscience, Department of Cognitive Sciences, University of California, Irvine, CA 92697, USA
J Neurophysiol 101:2725-32. 2009
..This result suggests that just as the PPC supports sensorimotor integration for eye and limb movements, area Spt forms part of a sensory-motor integration circuit for the vocal tract...
- Developmental delays consistent with cochlear hypothyroidism contribute to failure to develop hearing in mice lacking Slc26a4/pendrin expression
Anatomy and Physiology Department, Kansas State University, Manhattan, KS 66506, USA
Am J Physiol Renal Physiol 297:F1435-47. 2009
..developmental delays, possibly mediated by systemic or local hypothyroidism, contribute to the failure to develop hearing in mice lacking Slc26a4 (Slc26a4(-/-))...
- Tuning of the outer hair cell motor by membrane cholesterol
Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Huffington Center on Aging and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 282:36659-70. 2007
..We observed that alterations of cochlear cholesterol modulate hearing in mice...
- Developmental regulation of spontaneous activity in the Mammalian cochlea
Nicolas X Tritsch
The Solomon H Snyder Department of Neuroscience and Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Neurosci 30:1539-50. 2010
Neurons in the developing auditory system fire bursts of action potentials before the onset of hearing. This spontaneous activity promotes the survival and maturation of auditory neurons and the refinement of synaptic connections in ..
- Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary study
Ruikang K Wang
Oregon Health and Science University, Department of Biomedical Engineering, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239, USA
J Biomed Opt 15:056005. 2010
b>Hearing loss can mean severe impairment to the quality of life. However, the biomechanical mechanisms of how the hearing organ, i.e...
- Tricellulin is a tight-junction protein necessary for hearing
Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
Am J Hum Genet 79:1040-51. 2006
..spaces of the organ of Corti; the separation from one another by epithelial barriers is required for normal hearing. TRIC encodes tricellulin, a recently discovered tight-junction (TJ) protein that contributes to the structure ..
- Musical experience and the aging auditory system: implications for cognitive abilities and hearing speech in noise
Auditory Neuroscience Laboratory, Northwestern University, Evanston, Illinois, United States of America
PLoS ONE 6:e18082. 2011
..Although aging is generally accompanied by hearing loss, this perceptual decline cannot fully account for the difficulties experienced by older adults for hearing ..
- Targeted three-dimensional immunohistochemistry reveals localization of presynaptic proteins Bassoon and Piccolo in the rat calyx of Held before and after the onset of hearing
Department of Anatomy and Cell Biology, University of Heidelberg, 69120 Heidelberg, Germany
J Comp Neurol 518:1008-29. 2010
..3D localization of Bassoon and Piccolo in the rat calyx of Held between postnatal days 9 and 21, the period of hearing onset characterized by pronounced structural and functional changes...
- Development of form and function in the mammalian cochlea
Michael C Kelly
Department of Cell Biology, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
Curr Opin Neurobiol 19:395-401. 2009
- Tinnitus in hamsters following exposure to intense sound
Henry E Heffner
Department of Psychology, University of Toledo, Toledo, OH 43606, USA
Hear Res 170:83-95. 2002
..5 and 1 h did not. The degree of hearing loss produced by the tone exposure was assessed using behavioral and auditory brainstem response (ABR) procedures...
- Harmonin mutations cause mechanotransduction defects in cochlear hair cells
Department of Cell Biology, Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, CA 92037, USA
Neuron 62:375-87. 2009
..interactions with CDH23 and F-actin control harmonin localization in stereocilia and are necessary for normal hearing. In mice expressing a mutant harmonin protein that prevents UTLD formation, the sensitivity of hair bundles to ..
- Effects of hearing aid fitting on the perceptual characteristics of tinnitus
Laboratoire de Neurobiologie Integrative et Adaptative, UMR CNRS 6149, 3 Place Victor Hugo, Marseille, F 13331 Cedex 03, France
Hear Res 254:82-91. 2009
Restoration of auditory input through the use of hearing aids has been proposed as a potentially important means of altering tinnitus among those tinnitus sufferers who experience significant sensorineural hearing loss...
- Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells
InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University Medical Center Gottingen, Gottingen, Germany
Nat Neurosci 13:869-76. 2010
..that an aspartate to glycine substitution in the C(2)F domain of the synaptic vesicle protein otoferlin impaired hearing by reducing vesicle replenishment in the pachanga mouse model of human deafness DFNB9...
- Hearing speech sounds: top-down influences on the interface between audition and speech perception
Matthew H Davis
MRC Cognition and Brain Sciences Unit, Cambridge, UK
Hear Res 229:132-47. 2007
..We propose that top-down interactive mechanisms within auditory networks play an important role in explaining the perception of spoken language...
- The tectorial membrane: one slice of a complex cochlear sandwich
Guy P Richardson
School of Life Sciences, University of Sussex, Falmer, Brighton, UK
Curr Opin Otolaryngol Head Neck Surg 16:458-64. 2008
..is both timely and relevant, as recent findings have shown the tectorial membrane plays a more dynamic role in hearing than hitherto suspected, and that many forms of deafness can result from mutations in tectorial membrane proteins.
- A comparative study of hearing ability in fishes: the auditory brainstem response approach
T N Kenyon
T H Morgan School of Biological Sciences, University of Kentucky, Lexington 40506 0225, USA
J Comp Physiol A 182:307-18. 1998
..ABR) techniques, an electrophysiological far-field recording method widely used in clinical evaluation of human hearing, were adapted for fishes to overcome the major limitations of traditional behavioral and electrophysiological ..
- Role of corticofugal feedback in hearing
Department of Biology, Washington University, One Brookings Drive, St Louis, MO 63130, USA
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 194:169-83. 2008
..The corticofugal system has multiple functions. One of the most important functions is the improvement and adjustment (reorganization) of subcortical auditory signal processing for cortical signal processing...
- Development of form and function in peripheral auditory structures of the zebrafish (Danio rerio)
Dennis M Higgs
Department of Biology, University of Maryland, College Park, Maryland 20742, USA
J Acoust Soc Am 113:1145-54. 2003
..of frequency range coincided with the development of Weberian ossicles in zebrafish, suggesting that changes in hearing ability in this species are driven more by development of auxiliary specializations than by the ear itself...
- Visual advantage in deaf adults linked to retinal changes
Academic Unit of Ophthalmology and Orthoptics, University of Sheffield, Sheffield, United Kingdom
PLoS ONE 6:e20417. 2011
..We investigated neural changes at the retina and optic nerve head in profoundly deaf (N = 14) and hearing (N = 15) adults using Optical Coherence Tomography (OCT), an in-vivo light interference method of quantifying ..
- Seasonal plasticity of peripheral auditory frequency sensitivity
Joseph A Sisneros
Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
J Neurosci 23:1049-58. 2003
- Is there a role of visual cortex in spatial hearing?
Section Neuropsychology, Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
Eur J Neurosci 20:3148-56. 2004
..This result suggests a relation of neural processing in the visual cortex and the transformation of auditory spatial coordinates responsible for maintaining the perceptual alignment of audition and vision with changes in gaze direction...
- Frequency organization of the 40-Hz auditory steady-state response in normal hearing and in tinnitus
Department of Psychology, University of Konstanz, Box D25, 78457 Konstanz, Germany
Neuroimage 33:180-94. 2006
..representations in the region of primary auditory cortex (PAC) between subjects with chronic tinnitus and hearing impairment and normal hearing controls...
- Expression of a potassium current in inner hair cells during development of hearing in mice
C J Kros
Department of Physiology, School of Medical Sciences, University of Bristol, UK
Nature 394:281-4. 1998
..This change in potassium channel expression turns the inner hair cell from a regenerative, spiking pacemaker into a high-frequency signal transducer...
- Progressive hereditary hearing impairment caused by a MYO6 mutation resembles presbyacusis
A M M Oonk
Department of Otorhinolaryngology, Hearing and Genes, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Hear Res 299:88-98. 2013
..A Dutch family with autosomal dominantly inherited sensorineural hearing loss was clinically and genetically assessed...
- Human hearing enhanced by noise
F G Zeng
Department of Hearing and Speech Sciences and Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD 20742, USA
Brain Res 869:251-5. 2000
..data showing that signal detection and discrimination can be enhanced by noise in human subjects whose hearing is evoked by either normal acoustic stimulation or electric stimulation of the auditory nerve or the brainstem...
- Sensorineural hearing impairment in patients with Pmp22 duplication, deletion, and frameshift mutations
W I M Verhagen
Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
Otol Neurotol 26:405-14. 2005
To characterize and distinguish the types of sensorineural hearing impairment (SNHI) that occur in hereditary motor and sensory neuropathy Type 1a (HMSN-1a) and hereditary neuropathy with liability to pressure palsies (HNPP), which are ..
- Longitudinal analysis of hearing before and after radiosurgery for vestibular schwannoma
Department of Functional Neurosurgery, CHU Timone, APHM, Marseille, France
J Neurosurg 117:877-85. 2012
The aim of this study was to perform an accurate analysis of changes in hearing in patients with vestibular schwannoma (VS) who have undergone Gamma Knife surgery (GKS) and distinguish the impact of radiosurgery from the natural course ..
- Normal hearing sensitivity at low-to-middle frequencies with 34% prestin-charge density
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN, USA
PLoS ONE 7:e45453. 2012
The mammalian outer hair cells (OHCs) provide a positive mechanical feedback to enhance the cochlea's hearing sensitivity and frequency selectivity...
- Active hair bundle movements and the cochlear amplifier
Neuroscience Center and Kresge Hearing Labs, Louisiana State Health Sciences Center, New Orleans 70112, USA
J Am Acad Audiol 14:325-38. 2003
..to describe amplification and filtering processes that are essential for obtaining the exquisite sensitivity of hearing organs...
- Auditory sensory memory and working memory processes in children with normal hearing and cochlear implants
D R Watson
Division of Psychiatry and Neuroscience, School of Medicine, Queen s University of Belfast, Belfast, UK
Audiol Neurootol 12:65-76. 2007
There can be wide variation in the level of oral/aural language ability that prelingually hearing-impaired children develop after cochlear implantation...
- CyberKnife radiosurgery for vestibular schwannoma
Department of Neurosurgery, Clinical Neuroscience, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
Minim Invasive Neurosurg 47:290-3. 2004
..The CyberKnife is newly developed equipment for radiosurgery and fractionated radiosurgery. The authors report on their experience using the CyberKnife in 38 patients with vestibular schwannoma who were treated between 1998 to 2002...
- Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing
Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Neurosci 25:4052-61. 2005
Mechanosensory channels of sensory cells mediate the sensations of hearing, touch, and some forms of pain...
- Neural organization for recognition of grammatical and emotional facial expressions in deaf ASL signers and hearing nonsigners
Laboratory for Cognitive Neuroscience, The Salk Institute for Biological Studies 10010 North Torrey Pines Rd La Jolla, CA 92037, USA
Brain Res Cogn Brain Res 22:193-203. 2005
..neural systems underlying recognition of these functionally distinct expressions, comparing deaf ASL signers and hearing nonsigners...
- Reversible long-term changes in auditory processing in mature auditory cortex in the absence of hearing loss induced by passive, moderate-level sound exposure
Departments of Physiology and Pharmacology, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada
Ear Hear 33:305-14. 2012
..damage to the hair cells of the cochlea and the auditory nerve fibers, even if the resulting partial loss of hearing sensitivity, usually accompanied by tinnitus, disappears within hours or days of the exposure...
- Analysis of cochlear protein profiles of Wistar, Sprague-Dawley, and Fischer 344 rats with normal hearing function
Center for Hearing and Deafness, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA
J Proteome Res 8:3520-8. 2009
..Normal hearing function of the animals was ascertained using distortion product otoacoustic emissions (DPOAE)...
- Comparison of auditory electrophysiological responses in normal-hearing patients with and without tinnitus
Department of Otolaryngology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
J Laryngol Otol 125:668-72. 2011
Tinnitus is a disturbing symptom and is often the main reason for otology referral. It is usually associated with hearing loss of varying aetiology, and is thought to begin in the cochlea, with later abnormal central activity...
- Mice lacking the B1 subunit of H+ -ATPase have normal hearing
Center for Hearing and Deafness Research, Department of Pediatric Otolaryngology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Hear Res 180:76-84. 2003
..clinical data from individuals affected by autosomal recessive distal renal tubular acidosis with sensorineural hearing loss...
- A network for sensory-motor integration: what happens in the auditory cortex during piano playing without acoustic feedback?
Department of Neuropsychology, University of Zurich, Treichlerstrasse 10, CH 8032 Zurich, Switzerland
Ann N Y Acad Sci 1060:186-8. 2005
..We provide evidence for the existence of a neuronal network of secondary and higher-order areas belonging to the auditory and motor modality that is important in the integration of auditory and motor domains...
- Ion flow in cochlear hair cells and the regulation of hearing sensitivity
The Auditory Laboratory M311, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley 6009, Australia
Hear Res 280:3-20. 2011
..how ion transport proteins in the hair cells of the mammalian cochlea work to produce a sensitive but stable hearing organ...
- Output sound pressure levels of personal music systems and their effect on hearing
Dr MV Shetty College of Speech and Hearing, Vidyanagar, Mangalore 575 013, India
Noise Health 11:132-40. 2009
..Further, the effect of these PMS on hearing was evaluated by comparing the distortion product otoacoustic emissions and high frequency pure tone thresholds (..
- A genetic approach to understanding auditory function
K P Steel
Medical Research Council Institute of Hearing Research, University of Nottingham, Nottingham, UK
Nat Genet 27:143-9. 2001
..auditory transduction, as it makes no assumptions about the nature or expression level of molecules essential for hearing. We review here some of the major advances in our understanding of auditory function resulting from the recent ..
- Tectorial membrane travelling waves underlie abnormal hearing in Tectb mutant mice
Speech and Hearing Bioscience and Technology Program, Harvard MIT Division of Health Sciences and Technology, Cambridge, Massachusetts 02139, USA
Nat Commun 1:96. 2010
Remarkable sensitivity and exquisite frequency selectivity are hallmarks of mammalian hearing, but their underlying mechanisms remain unclear...
- Two-year decline in vision but not hearing is associated with memory decline in very old adults in a population-based sample
K J Anstey
Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
Gerontology 47:289-93. 2001
..However, the nature of the association is still unclear, particularly with respect to whether sensory and cognitive function are causally related...