hearing

Summary

Summary: The sensation of sound.

Top Publications

  1. doi Cetaceans on a molecular fast track to ultrasonic hearing
    Yang Liu
    School of Life Sciences, East China Normal University, Shanghai, China
    Curr Biol 20:1834-9. 2010
  2. ncbi A comprehensive analysis of hearing preservation after radiosurgery for vestibular schwannoma
    Isaac Yang
    Department of Neurological Surgery, University of California at San Francisco, California 94117, USA
    J Neurosurg 112:851-9. 2010
  3. pmc Thyroid hormone receptor beta-dependent expression of a potassium conductance in inner hair cells at the onset of hearing
    A Rusch
    Physiologisches Institut, Gmelinstrasse 5, and Sektion Sensorische Biophysik, Hals Nasen Ohren Klinik, Röntgenweg 11, Universität T ubingen, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 95:15758-62. 1998
  4. ncbi High-frequency tinnitus without hearing loss does not mean absence of deafferentation
    Nathan Weisz
    Department of Psychology, University of Konstanz, Germany
    Hear Res 222:108-14. 2006
  5. doi The hearing gene Prestin unites echolocating bats and whales
    Ying Li
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Curr Biol 20:R55-6. 2010
  6. ncbi The functional significance of mu rhythms: translating "seeing" and "hearing" into "doing"
    Jaime A Pineda
    Department of Cognitive Science and Neuroscience, University of California, San Diego, La Jolla, CA 92037 0515, USA
    Brain Res Brain Res Rev 50:57-68. 2005
  7. pmc Parallel signatures of sequence evolution among hearing genes in echolocating mammals: an emerging model of genetic convergence
    K T J Davies
    School of Biological and Chemical Sciences, Queen Mary University of London, London, UK
    Heredity (Edinb) 108:480-9. 2012
  8. pmc The hearing gene Prestin reunites echolocating bats
    Gang Li
    School of Life Science, East China Normal University, Shanghai 200062, China
    Proc Natl Acad Sci U S A 105:13959-64. 2008
  9. ncbi The sensory and motor roles of auditory hair cells
    Robert Fettiplace
    Department of Physiology, University of Wisconsin Medical School, 185 Medical Sciences Building, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nat Rev Neurosci 7:19-29. 2006
  10. ncbi Key functions for gap junctions in skin and hearing
    Claire A Scott
    Centre for Cutaneous Research, The Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
    Biochem J 438:245-54. 2011

Detail Information

Publications310 found, 100 shown here

  1. doi Cetaceans on a molecular fast track to ultrasonic hearing
    Yang Liu
    School of Life Sciences, East China Normal University, Shanghai, China
    Curr Biol 20:1834-9. 2010
    ..Echolocation in toothed whales demands exceptional high-frequency hearing [3], and both echolocation and ultrasonic hearing have also evolved independently in bats [4, 5]...
  2. ncbi A comprehensive analysis of hearing preservation after radiosurgery for vestibular schwannoma
    Isaac Yang
    Department of Neurological Surgery, University of California at San Francisco, California 94117, USA
    J Neurosurg 112:851-9. 2010
    ..b>Hearing preservation rates in GKS series suggest very favorable outcomes without the possible acute morbidity associated ..
  3. pmc Thyroid hormone receptor beta-dependent expression of a potassium conductance in inner hair cells at the onset of hearing
    A Rusch
    Physiologisches Institut, Gmelinstrasse 5, and Sektion Sensorische Biophysik, Hals Nasen Ohren Klinik, Röntgenweg 11, Universität T ubingen, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 95:15758-62. 1998
    To elucidate the role of thyroid hormone receptors (TRs) alpha1 and beta in the development of hearing, cochlear functions have been investigated in mice lacking TRalpha1 or TRbeta...
  4. ncbi High-frequency tinnitus without hearing loss does not mean absence of deafferentation
    Nathan Weisz
    Department of Psychology, University of Konstanz, Germany
    Hear Res 222:108-14. 2006
    ..The absence of audiometrically detectable hearing loss however poses a challenge to this rather generalizing assumption...
  5. doi The hearing gene Prestin unites echolocating bats and whales
    Ying Li
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Curr Biol 20:R55-6. 2010
    ..substantially in many aspects [2], we here report the surprising finding that the bottlenose dolphin, a toothed whale, is clustered with microbats in the gene tree constructed using protein sequences encoded by the hearing gene Prestin.
  6. ncbi The functional significance of mu rhythms: translating "seeing" and "hearing" into "doing"
    Jaime A Pineda
    Department of Cognitive Science and Neuroscience, University of California, San Diego, La Jolla, CA 92037 0515, USA
    Brain Res Brain Res Rev 50:57-68. 2005
    ..processing function that links perception and action-specifically, the transformation of "seeing" and "hearing" into "doing...
  7. pmc Parallel signatures of sequence evolution among hearing genes in echolocating mammals: an emerging model of genetic convergence
    K T J Davies
    School of Biological and Chemical Sciences, Queen Mary University of London, London, UK
    Heredity (Edinb) 108:480-9. 2012
    ..in the Prestin gene among some bats and cetaceans suggest that parallel adaptations for high-frequency hearing have taken place during the evolution of echolocation...
  8. pmc The hearing gene Prestin reunites echolocating bats
    Gang Li
    School of Life Science, East China Normal University, Shanghai 200062, China
    Proc Natl Acad Sci U S A 105:13959-64. 2008
    ..Echolocating bats use ultrasound for orientation and hunting and possess the highest frequency hearing of all mammals...
  9. ncbi The sensory and motor roles of auditory hair cells
    Robert Fettiplace
    Department of Physiology, University of Wisconsin Medical School, 185 Medical Sciences Building, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Nat Rev Neurosci 7:19-29. 2006
    ..Both motor mechanisms are probably needed to provide the high sensitivity and frequency discrimination of the mammalian cochlea...
  10. ncbi Key functions for gap junctions in skin and hearing
    Claire A Scott
    Centre for Cutaneous Research, The Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
    Biochem J 438:245-54. 2011
    ..3 and Cx31 which lead to skin disease and deafness. Functional studies with Cx proteins have given insights into disease-associated mechanisms and non-gap junctional roles for Cx proteins...
  11. pmc Review series: The cell biology of hearing
    Martin Schwander
    Department of Cell Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 190:9-20. 2010
    ..The study of genes that are linked to deafness has provided insights into the cell biological mechanisms that control hair cell development and their function as mechanosensors...
  12. doi The neural basis of Drosophila gravity-sensing and hearing
    Azusa Kamikouchi
    Sensory Systems Laboratory, Institute of Zoology, University of Cologne, 50923 Cologne, Germany
    Nature 458:165-71. 2009
    ..Here we focus on two of the remaining and less understood prime sensory modalities: graviception and hearing. We show that the fly has implemented both sensory modalities into a single system, Johnston's organ, which ..
  13. ncbi Effects of hearing aid amplification and stimulus intensity on cortical auditory evoked potentials
    Curtis J Billings
    Department of Speech and Hearing Sciences, University of Washington, Seattle, WA 98105, USA
    Audiol Neurootol 12:234-46. 2007
    b>Hearing aid amplification can be used as a model for studying the effects of auditory stimulation on the central auditory system (CAS)...
  14. pmc Hearing lips and seeing voices: how cortical areas supporting speech production mediate audiovisual speech perception
    Jeremy I Skipper
    Department of Neurology, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Cereb Cortex 17:2387-99. 2007
    ....
  15. ncbi The remarkable cochlear amplifier
    J Ashmore
    Department of Neuroscience, Physiology and Pharmacology and UCL Ear Institute, Gower Street, London WC1E 6BT, UK
    Hear Res 266:1-17. 2010
    ..These experiments are presently lacking but if successfully performed would have an enormous impact on our understanding of the cochlear amplifier...
  16. ncbi Hearing visual motion in depth
    Norimichi Kitagawa
    Department of Psychology, Tokyo Metropolitan University, 1 1, Minami Osawa, Hachioji shi, Tokyo 192 0397, Japan
    Nature 416:172-4. 2002
    ..The results provide psychophysical evidence that, for processing of motion in depth, the auditory system responds to both auditory changing intensity and visual motion in depth...
  17. pmc Structural determinants of cadherin-23 function in hearing and deafness
    Marcos Sotomayor
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 66:85-100. 2010
    ..The structures define an uncharacterized cadherin family and, with simulations, suggest mechanisms underlying inherited deafness and how cadherin-23 may bind with itself and with protocadherin-15 to form the tip link...
  18. pmc Relationship between swim bladder morphology and hearing abilities--a case study on Asian and African cichlids
    Tanja Schulz-Mirbach
    Department of Behavioral Biology, University of Vienna, Vienna, Austria
    PLoS ONE 7:e42292. 2012
    ..A few comparative studies have shown that these morphological specializations may enhance hearing abilities...
  19. ncbi Baby hands that move to the rhythm of language: hearing babies acquiring sign languages babble silently on the hands
    Laura Ann Petitto
    Department of Psychological and Brain Sciences and Department of Education, Raven House, Dartmouth College, Hanover, NH 03755, USA
    Cognition 93:43-73. 2004
    ..Two groups of hearing babies were studied over time (ages 6, 10, and 12 months), equal in all developmental respects except for the ..
  20. ncbi Reading, hearing, and the planum temporale
    Bradley R Buchsbaum
    Department of Health and Human Services, Unit on Integrative Neuroimaging, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1365, USA
    Neuroimage 24:444-54. 2005
    ..Moreover, increasing the smoothing window to 10 mm obliterates activation in the PT, suggesting that failure to find PT activation in past studies may relate to this factor...
  21. pmc Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition
    Byung Yoon Choi
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, USA
    J Clin Invest 121:4516-25. 2011
    Mutations in human SLC26A4 are a common cause of hearing loss associated with enlarged vestibular aqueducts (EVA)...
  22. ncbi Otoacoustic emissions in a hearing conservation program: general applicability in longitudinal monitoring and the relation to changes in pure-tone thresholds
    Hiske W Helleman
    Clinical and Experimental Audiology, ENT Department, Academic Medical Centre, Amsterdam, The Netherlands
    Int J Audiol 49:410-9. 2010
    The hearing status of workers (N = 233) in a printing office was assessed twice within seventeen months by pure-tone audiometry and otoacoustic emissions (OAEs)...
  23. ncbi Audition in sciaenid fishes with different swim bladder-inner ear configurations
    John U Ramcharitar
    Department of Biology and Neuroscience and Cognitive Science Program, University of Maryland, College Park, Maryland 20742, USA
    J Acoust Soc Am 119:439-43. 2006
    We investigated how morphological differences in the auditory periphery of teleost fishes may relate to hearing capabilities...
  24. ncbi Lefties get it "right" when hearing tool sounds
    James W Lewis
    Department of Physiology and Phamacology, West Virginia University, WV 26506 9229, USA
    J Cogn Neurosci 18:1314-30. 2006
    ..In right-handers, we previously reported that hearing hand-manipulated tool sounds preferentially activates a left hemisphere network of motor-related brain regions ..
  25. ncbi Electrical stimulation of the midbrain for hearing restoration: insight into the functional organization of the human central auditory system
    Hubert H Lim
    Otorhinolaryngology Department, Hannover Medical University, 30625 Hannover, Germany
    J Neurosci 27:13541-51. 2007
    The cochlear implant can restore speech perception in patients with sensorineural hearing loss. However, it is ineffective for those without an implantable cochlea or a functional auditory nerve...
  26. pmc Normal hearing is not enough to guarantee robust encoding of suprathreshold features important in everyday communication
    Dorea Ruggles
    Department of Biomedical Engineering, Boston University Hearing Research Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:15516-21. 2011
    Normal hearing" is typically defined by threshold audibility, even though everyday communication relies on extracting key features of easily audible sound, not on sound detection...
  27. pmc The role of temporal fine structure processing in pitch perception, masking, and speech perception for normal-hearing and hearing-impaired people
    Brian C J Moore
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    J Assoc Res Otolaryngol 9:399-406. 2008
    ..Evidence is reviewed suggesting that cochlear hearing loss reduces the ability to use TFS cues...
  28. ncbi The case for early identification of hearing loss in children. Auditory system development, experimental auditory deprivation, and development of speech perception and hearing
    Y S Sininger
    Children s Auditory Research and Evaluation Center, University of California Davis Medical Center, USA
    Pediatr Clin North Am 46:1-14. 1999
    ..Although it is not visible to observers, infants with hearing are learning to process speech and understand language and are quite linguistically sophisticated by 1 year of ..
  29. doi Prestin's role in cochlear frequency tuning and transmission of mechanical responses to neural excitation
    Marcia M Mellado Lagarde
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
    Curr Biol 18:200-2. 2008
    ..Prestin is crucial for defining sharp and sensitive cochlear frequency tuning by reducing the sensitivity of the low-frequency tail of the tuning curve, although this necessitates a cochlear amplifier to determine the narrowly tuned tip...
  30. ncbi Hearing syllables by seeing visual stimuli
    Lutz Jancke
    University of Zurich, Institute of Psychology, Division of Neuropsychology, Treichlerstr 10, Switzerland
    Eur J Neurosci 19:2603-8. 2004
    ..To overcome the detrimental effects of scanner noise, one group of subjects was trained to vividly imagine hearing a syllable while a flashlight was presented. A control group did not receive this training...
  31. ncbi Hearing speech sounds: top-down influences on the interface between audition and speech perception
    Matthew H Davis
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Hear Res 229:132-47. 2007
    ..We propose that top-down interactive mechanisms within auditory networks play an important role in explaining the perception of spoken language...
  32. ncbi Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila
    Zhefeng Gong
    Biology Department, University of Virginia, Charlottesville, Virginia 22904, USA
    J Neurosci 24:9059-66. 2004
    b>Hearing in Drosophila depends on the transduction of antennal vibration into receptor potentials by ciliated sensory neurons in Johnston's organ, the antennal chordotonal organ...
  33. doi Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells
    Tina Pangrsic
    InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University Medical Center Gottingen, Gottingen, Germany
    Nat Neurosci 13:869-76. 2010
    ..that an aspartate to glycine substitution in the C(2)F domain of the synaptic vesicle protein otoferlin impaired hearing by reducing vesicle replenishment in the pachanga mouse model of human deafness DFNB9...
  34. pmc Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary study
    Ruikang K Wang
    Oregon Health and Science University, Department of Biomedical Engineering, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 15:056005. 2010
    b>Hearing loss can mean severe impairment to the quality of life. However, the biomechanical mechanisms of how the hearing organ, i.e...
  35. doi Rethinking sound detection by fishes
    Arthur N Popper
    Department of Biology and Center for Comparative and Evolutionary Biology of Hearing, University of Maryland, College Park, MD 20742, USA
    Hear Res 273:25-36. 2011
    In this paper we reconsider the designation of fishes as being either "hearing specialists" or "hearing generalists," and recommend dropping the terms...
  36. pmc Musical experience and the aging auditory system: implications for cognitive abilities and hearing speech in noise
    Alexandra Parbery-Clark
    Auditory Neuroscience Laboratory, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 6:e18082. 2011
    ..Although aging is generally accompanied by hearing loss, this perceptual decline cannot fully account for the difficulties experienced by older adults for hearing ..
  37. pmc Harmonin mutations cause mechanotransduction defects in cochlear hair cells
    Nicolas Grillet
    Department of Cell Biology, Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuron 62:375-87. 2009
    ..interactions with CDH23 and F-actin control harmonin localization in stereocilia and are necessary for normal hearing. In mice expressing a mutant harmonin protein that prevents UTLD formation, the sensitivity of hair bundles to ..
  38. pmc Tricellulin is a tight-junction protein necessary for hearing
    Saima Riazuddin
    Section on Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Am J Hum Genet 79:1040-51. 2006
    ..spaces of the organ of Corti; the separation from one another by epithelial barriers is required for normal hearing. TRIC encodes tricellulin, a recently discovered tight-junction (TJ) protein that contributes to the structure ..
  39. ncbi Tinnitus in hamsters following exposure to intense sound
    Henry E Heffner
    Department of Psychology, University of Toledo, Toledo, OH 43606, USA
    Hear Res 170:83-95. 2002
    ..5 and 1 h did not. The degree of hearing loss produced by the tone exposure was assessed using behavioral and auditory brainstem response (ABR) procedures...
  40. doi Effects of hearing aid fitting on the perceptual characteristics of tinnitus
    G Moffat
    Laboratoire de Neurobiologie Integrative et Adaptative, UMR CNRS 6149, 3 Place Victor Hugo, Marseille, F 13331 Cedex 03, France
    Hear Res 254:82-91. 2009
    Restoration of auditory input through the use of hearing aids has been proposed as a potentially important means of altering tinnitus among those tinnitus sufferers who experience significant sensorineural hearing loss...
  41. doi Targeted three-dimensional immunohistochemistry reveals localization of presynaptic proteins Bassoon and Piccolo in the rat calyx of Held before and after the onset of hearing
    Anna Dondzillo
    Department of Anatomy and Cell Biology, University of Heidelberg, 69120 Heidelberg, Germany
    J Comp Neurol 518:1008-29. 2010
    ..3D localization of Bassoon and Piccolo in the rat calyx of Held between postnatal days 9 and 21, the period of hearing onset characterized by pronounced structural and functional changes...
  42. ncbi Development of form and function in the mammalian cochlea
    Michael C Kelly
    Department of Cell Biology, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Curr Opin Neurobiol 19:395-401. 2009
    ....
  43. doi The corpus callosum in dichotic listening studies of hemispheric asymmetry: a review of clinical and experimental evidence
    Rene Westerhausen
    Department of Biological and Medical Psychology, Cognitive Neuroscience Group, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Neurosci Biobehav Rev 32:1044-54. 2008
    ..The review has also revealed how inter-individual variability in callosal fiber structure affects both bottom-up and top-down performance on the dichotic listening task...
  44. ncbi A TRPV family ion channel required for hearing in Drosophila
    Janghwan Kim
    Department of Genetics, Hanwha Chemical Co R and D Center, Sinsung dong, Yusung Gu, Daejeon 305 345, Korea
    Nature 424:81-4. 2003
    ..Antennal sound-evoked potentials are completely absent in mutants lacking Nan, showing that it is an essential component of the chordotonal mechanotransducer...
  45. ncbi Seasonal plasticity of peripheral auditory frequency sensitivity
    Joseph A Sisneros
    Department of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853, USA
    J Neurosci 23:1049-58. 2003
    ....
  46. ncbi Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier
    M Charles Liberman
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Nature 419:300-4. 2002
    b>Hearing sensitivity in mammals is enhanced by more than 40 dB (that is, 100-fold) by mechanical amplification thought to be generated by one class of cochlear sensory cells, the outer hair cells...
  47. ncbi Frequency organization of the 40-Hz auditory steady-state response in normal hearing and in tinnitus
    Christian Wienbruch
    Department of Psychology, University of Konstanz, Box D25, 78457 Konstanz, Germany
    Neuroimage 33:180-94. 2006
    ..representations in the region of primary auditory cortex (PAC) between subjects with chronic tinnitus and hearing impairment and normal hearing controls...
  48. ncbi Is there a role of visual cortex in spatial hearing?
    Ulrike Zimmer
    Section Neuropsychology, Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    Eur J Neurosci 20:3148-56. 2004
    ..This result suggests a relation of neural processing in the visual cortex and the transformation of auditory spatial coordinates responsible for maintaining the perceptual alignment of audition and vision with changes in gaze direction...
  49. ncbi Expression of a potassium current in inner hair cells during development of hearing in mice
    C J Kros
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    Nature 394:281-4. 1998
    ..This change in potassium channel expression turns the inner hair cell from a regenerative, spiking pacemaker into a high-frequency signal transducer...
  50. doi Comparison of auditory electrophysiological responses in normal-hearing patients with and without tinnitus
    S Singh
    Department of Otolaryngology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    J Laryngol Otol 125:668-72. 2011
    Tinnitus is a disturbing symptom and is often the main reason for otology referral. It is usually associated with hearing loss of varying aetiology, and is thought to begin in the cochlea, with later abnormal central activity...
  51. doi Reversible long-term changes in auditory processing in mature auditory cortex in the absence of hearing loss induced by passive, moderate-level sound exposure
    Martin Pienkowski
    Departments of Physiology and Pharmacology, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada
    Ear Hear 33:305-14. 2012
    ..damage to the hair cells of the cochlea and the auditory nerve fibers, even if the resulting partial loss of hearing sensitivity, usually accompanied by tinnitus, disappears within hours or days of the exposure...
  52. ncbi Mice lacking the B1 subunit of H+ -ATPase have normal hearing
    Hongwei Dou
    Center for Hearing and Deafness Research, Department of Pediatric Otolaryngology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Hear Res 180:76-84. 2003
    ..clinical data from individuals affected by autosomal recessive distal renal tubular acidosis with sensorineural hearing loss...
  53. ncbi Analysis of cochlear protein profiles of Wistar, Sprague-Dawley, and Fischer 344 rats with normal hearing function
    Samson Jamesdaniel
    Center for Hearing and Deafness, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA
    J Proteome Res 8:3520-8. 2009
    ..Normal hearing function of the animals was ascertained using distortion product otoacoustic emissions (DPOAE)...
  54. doi Output sound pressure levels of personal music systems and their effect on hearing
    Ajith Kumar
    Dr MV Shetty College of Speech and Hearing, Vidyanagar, Mangalore 575 013, India
    Noise Health 11:132-40. 2009
    ..Further, the effect of these PMS on hearing was evaluated by comparing the distortion product otoacoustic emissions and high frequency pure tone thresholds (..
  55. pmc Tuning of the outer hair cell motor by membrane cholesterol
    Lavanya Rajagopalan
    Bobby R Alford Department of Otolaryngology Head and Neck Surgery, Huffington Center on Aging and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:36659-70. 2007
    ..We observed that alterations of cochlear cholesterol modulate hearing in mice...
  56. doi Ion flow in cochlear hair cells and the regulation of hearing sensitivity
    Robert Patuzzi
    The Auditory Laboratory M311, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley 6009, Australia
    Hear Res 280:3-20. 2011
    ..how ion transport proteins in the hair cells of the mammalian cochlea work to produce a sensitive but stable hearing organ...
  57. ncbi A network for sensory-motor integration: what happens in the auditory cortex during piano playing without acoustic feedback?
    Simon Baumann
    Department of Neuropsychology, University of Zurich, Treichlerstrasse 10, CH 8032 Zurich, Switzerland
    Ann N Y Acad Sci 1060:186-8. 2005
    ..We provide evidence for the existence of a neuronal network of secondary and higher-order areas belonging to the auditory and motor modality that is important in the integration of auditory and motor domains...
  58. pmc A systematic review of studies measuring and reporting hearing aid usage in older adults since 1999: a descriptive summary of measurement tools
    Elvira Pérez
    National Biomedical Research Unit in Hearing, National Institute for Health Research NIHR, Nottingham, United Kingdom
    PLoS ONE 7:e31831. 2012
    ..conducted to identify and quality assess how studies published since 1999 have measured and reported the usage of hearing aids in older adults...
  59. doi Hearing and morphological specializations of the mojarra (Eucinostomus argenteus)
    Eric Parmentier
    Laboratoire de Morphologie Fonctionnelle et Evolutive, Institut de Chimie, Bât B6, Universite de Liege, B 4000 Liege, Belgium
    J Exp Biol 214:2697-701. 2011
    ..b>Hearing tests show the mojarra has better hearing sensitivity than other species of fish without a connection...
  60. ncbi The otolithic organ as a receptor of vestibular hearing revealed by vestibular-evoked myogenic potentials in patients with inner ear anomalies
    Kianoush Sheykholeslami
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku 113 0033, Japan
    Hear Res 165:62-7. 2002
    ..The contribution of this response to the perception of loud sounds is discussed. It is concluded that vestibular response to sound might be used to assist in the rehabilitation of deafness...
  61. pmc Tectorial membrane travelling waves underlie abnormal hearing in Tectb mutant mice
    Roozbeh Ghaffari
    Speech and Hearing Bioscience and Technology Program, Harvard MIT Division of Health Sciences and Technology, Cambridge, Massachusetts 02139, USA
    Nat Commun 1:96. 2010
    Remarkable sensitivity and exquisite frequency selectivity are hallmarks of mammalian hearing, but their underlying mechanisms remain unclear...
  62. ncbi Drosophila auditory organ genes and genetic hearing defects
    Pingkalai R Senthilan
    Department of Cellular Neurobiology, University of Gottingen, Julia Lermontowa Weg 3, 37077 Gottingen, Germany
    Cell 150:1042-54. 2012
    ..Only four of these genes had previously been associated with fly hearing, yet one in five of the genes that we identified has a human cognate that is implicated in hearing disorders...
  63. ncbi Hearing colors, tasting shapes
    Vilayanur S Ramachandran
    Sci Am 288:52-9. 2003
  64. ncbi Two-year decline in vision but not hearing is associated with memory decline in very old adults in a population-based sample
    K J Anstey
    Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
    Gerontology 47:289-93. 2001
    ..However, the nature of the association is still unclear, particularly with respect to whether sensory and cognitive function are causally related...
  65. doi A false killer whale adjusts its hearing when it echolocates
    Paul E Nachtigall
    Marine Mammal Research Program, Hawaii Institute of Marine Biology, University of Hawaii, PO Box 1106, Kailua, HI 96734, USA
    J Exp Biol 211:1714-8. 2008
    The use of auditory evoked potential (AEP) measurements has added considerably to knowledge of the hearing mechanisms of marine mammals...
  66. ncbi A genetic approach to understanding auditory function
    K P Steel
    Medical Research Council Institute of Hearing Research, University of Nottingham, Nottingham, UK
    Nat Genet 27:143-9. 2001
    ..auditory transduction, as it makes no assumptions about the nature or expression level of molecules essential for hearing. We review here some of the major advances in our understanding of auditory function resulting from the recent ..
  67. doi Role of corticofugal feedback in hearing
    Nobuo Suga
    Department of Biology, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 194:169-83. 2008
    ..The corticofugal system has multiple functions. One of the most important functions is the improvement and adjustment (reorganization) of subcortical auditory signal processing for cortical signal processing...
  68. ncbi Development of ultrasound detection in American shad (Alosa sapidissima)
    D M Higgs
    Department of Biology, University of Windsor, Windsor, Ontario, N9B 3P4 Canada
    J Exp Biol 207:155-63. 2004
    ..Thus, it appears that ultrasound-detecting clupeiformes have undergone structural modification of the utricle that allows detection of ultrasonic stimulation...
  69. ncbi Gamma knife radiosurgery for vestibular schwannoma: early hearing outcomes and evaluation of the cochlear dose
    John M Lasak
    Department of Surgery, The University of Kansas School of Medicine, Wichita, Kansas, USA
    Otol Neurotol 29:1179-86. 2008
    To evaluate the hearing outcomes for a group of unilateral vestibular schwannoma patients treated with gamma knife radiosurgery and to determine if the cochlear radiation dose affects hearing outcome measures.
  70. ncbi Emergence of hearing in the chicken embryo
    Timothy A Jones
    Department of Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Greenville, NC 27858, USA
    J Neurophysiol 96:128-41. 2006
    It is commonly held that hearing generally begins on incubation day 12 (E12) in the chicken embryo (Gallus domesticus). However, little is known about the response properties of cochlear ganglion neurons for ages younger than E18...
  71. pmc Discrimination and identification of azimuth using spectral shape
    DANIEL E SHUB
    Speech and Hearing Bioscience and Technology Program, Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Acoust Soc Am 124:3132-41. 2008
    ..Measurements are reported for normal-hearing subjects, who listened with only one ear, and effectively monaural subjects, who had substantial unilateral ..
  72. pmc Essential role of retinoblastoma protein in mammalian hair cell development and hearing
    Cyrille Sage
    Neurology Service, Center for Nervous System Repair, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:7345-50. 2006
    ..However, adult pRb(-/-) mice exhibit profound hearing loss due to progressive degeneration of the organ of Corti...
  73. ncbi Prestin, the motor protein of outer hair cells
    Jing Zheng
    Department of Communication Sciences and Disorders, Auditory Physiology Laboratory, The Hugh Knowles Center, Northwestern University, Evanston, Ill 60208, USA
    Audiol Neurootol 7:9-12. 2002
    ..Prestin shares overall structure similarity with this anion transporter family. Recently, intracellular anions (chloride or bicarbonate) were found to be essential for OHC electromotility and prestin's function...
  74. ncbi Hearing illusory sounds in noise: the timing of sensory-perceptual transformations in auditory cortex
    Lars Riecke
    Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands
    Neuron 64:550-61. 2009
    ..Such fluctuations could facilitate stable hearing of fragmented sounds in natural environments.
  75. ncbi Evolution and function of auditory systems in insects
    A Stumpner
    Institut für Zoologie und Anthropologie, Universitat Gottingen, Germany
    Naturwissenschaften 88:159-70. 2001
    ..The behavioural context in which hearing has evolved has strongly determined the design and properties of the auditory system...
  76. pmc Ontogenetic development of auditory sensitivity and sound production in the squeaker catfish Synodontis schoutedeni
    Walter Lechner
    University of Vienna, Department of Behavioural Biology, Althanstrasse 14, 1090 Vienna, Austria
    BMC Biol 8:10. 2010
    Surveys of ontogenetic development of hearing and sound production in fish are scarce, and the ontogenetic development of acoustic communication has been investigated in only two fish species so far...
  77. ncbi Sound-induced differential motion within the hearing organ
    Anders Fridberger
    Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Nat Neurosci 6:446-8. 2003
  78. ncbi Sound localization under perturbed binaural hearing
    Marc M Van Wanrooij
    Department of Biophysics, Radboud University Nijmegen, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
    J Neurophysiol 97:715-26. 2007
    This paper reports on the acute effects of a monaural plug on directional hearing in the horizontal (azimuth) and vertical (elevation) planes of human listeners...
  79. ncbi Temporal integration vs. parallel processing: coping with the variability of neuronal messages in directional hearing of insects
    B Ronacher
    Department of Biology, Humboldt University, D 10099 Berlin, Germany
    Eur J Neurosci 12:2147-56. 2000
    ..Using the directional hearing of the grasshopper Chorthippus biguttulus (Ch...
  80. ncbi Otoacoustic emissions in universal hearing screening: which day after birth should we examine the newborns?
    Stavros Korres
    ENT Department of Athens National University, Ippokration Hospital, Athens, Greece
    ORL J Otorhinolaryngol Relat Spec 65:199-201. 2003
    Transiently evoked otoacoustic emissions (TEOAEs) have been widely used in universal newborn hearing screening programs...
  81. doi Soundscapes and the sense of hearing of fishes
    Richard Fay
    Parmly Hearing Institute, Loyola University Chicago, Chicago, IL 60626, USA
    Integr Zool 4:26-32. 2009
    ..A call is made to better understand underwater soundscapes, and the associated behaviors they determine in fishes...
  82. ncbi A comparative study of hearing ability in fishes: the auditory brainstem response approach
    T N Kenyon
    T H Morgan School of Biological Sciences, University of Kentucky, Lexington 40506 0225, USA
    J Comp Physiol A 182:307-18. 1998
    ..ABR) techniques, an electrophysiological far-field recording method widely used in clinical evaluation of human hearing, were adapted for fishes to overcome the major limitations of traditional behavioral and electrophysiological ..
  83. doi Subjective and objective results after bilateral cochlear implantation in adults
    Roman D Laske
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Zurich, Switzerland
    Otol Neurotol 30:313-8. 2009
    ..To assess and compare subjective and objective results after bilateral cochlear implantation with a special emphasis on time interval between the first and second implant...
  84. pmc Neural signature of the conscious processing of auditory regularities
    Tristan A Bekinschtein
    Cognitive Neuro Imaging Unit, Institut Fédératif de Recherche 49, Institut National de la Sante et de la Recherche Medicale, 91191 Gif sur Yvette, France
    Proc Natl Acad Sci U S A 106:1672-7. 2009
    ..This simple electrophysiological marker could thus serve as a useful clinical tool...
  85. pmc Developmental regulation of spontaneous activity in the Mammalian cochlea
    Nicolas X Tritsch
    The Solomon H Snyder Department of Neuroscience and Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 30:1539-50. 2010
    Neurons in the developing auditory system fire bursts of action potentials before the onset of hearing. This spontaneous activity promotes the survival and maturation of auditory neurons and the refinement of synaptic connections in ..
  86. ncbi Development of form and function in peripheral auditory structures of the zebrafish (Danio rerio)
    Dennis M Higgs
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    J Acoust Soc Am 113:1145-54. 2003
    ..of frequency range coincided with the development of Weberian ossicles in zebrafish, suggesting that changes in hearing ability in this species are driven more by development of auxiliary specializations than by the ear itself...
  87. doi Hearing ability in three clownfish species
    Eric Parmentier
    Laboratoire de Morphologie Fonctionnelle et Evolutive, Institut de Chimie, Bat B6c, Universite de Liege, B 4000 Liege, Belgium
    J Exp Biol 212:2023-6. 2009
    ..Data on the hearing ability of these fish are, however, needed to show that they have the sensory ability to detect the frequencies ..
  88. ncbi Hearing sounds, understanding actions: action representation in mirror neurons
    Evelyne Kohler
    Istituto di Fisiologia Umana, Universita di Parma, Italy, Dipartimento di Psicologia, Universita di Parma, Italy
    Science 297:846-8. 2002
    ....
  89. ncbi The origin of spontaneous activity in the developing auditory system
    Nicolas X Tritsch
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Nature 450:50-5. 2007
    ..Spontaneous ATP-dependent signalling rapidly subsides after the onset of hearing, thereby preventing this experience-independent activity from interfering with accurate encoding of sound...
  90. ncbi Rapid confocal imaging for measuring sound-induced motion of the hearing organ in the apical region
    Stefan Jacob
    Karolinska Institutet, Center for Hearing and Communication Research, Departments of Otolaryngology and Clinical Neuroscience, M1 Karolinska Universitetssjukhuset, SE 171 76 Stockholm, Sweden
    J Biomed Opt 12:021005. 2007
    ..The hearing organ is imaged with a standard laser scanning confocal microscope during sound stimulation...
  91. ncbi Hyperbaric oxygen and steroid therapy for idiopathic sudden sensorineural hearing loss
    Takeyuki Fujimura
    Department of Otorhinolaryngology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, 807 8555, Japan
    Eur Arch Otorhinolaryngol 264:861-6. 2007
    ..of hyperbaric oxygen (HBO) therapy combined with steroid administration for idiopathic sudden sensorineural hearing loss (ISSNHL) in comparison with that of steroid administration alone...
  92. ncbi The effect of isoflurane, halothane and pentobarbital on noise-induced hearing loss in mice
    Jong Woo Chung
    Department of Otolaryngology, Asan Medical Center, College of Medicine, University of Ulsan, Songpa Gu, Seoul, Korea
    Anesth Analg 104:1404-8, table of contents. 2007
    Ear surgery using mastoid drills can lead to noise-induced hearing loss (NIHL). We investigated whether inhaled anesthetics or pentobarbital could have protective effects on NIHL in mice.
  93. ncbi Audiometric patterns and prognosis in sudden sensorineural hearing loss in southern Taiwan
    Ning Chia Chang
    Department of Otolaryngology, Kaohsiung Medical University, Chung Ho Memorial Hospital, Taiwan
    Otolaryngol Head Neck Surg 133:916-22. 2005
    To investigate factors affecting the prognosis of sudden sensorineural hearing loss (SSNHL).
  94. pmc Choosing between measures: comparison of EQ-5D, HUI2 and HUI3 in persons with hearing complaints
    Janneke P C Grutters
    Department of Clinical Epidemiology and Medical Technology Assessment, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Qual Life Res 16:1439-49. 2007
    To generate insight into the differences between utility measures EuroQol 5D (EQ-5D), Health Utilities Index Mark II (HUI2) and Mark III (HUI3) and their impact on the incremental cost-effectiveness ratio (ICER) for hearing aid fitting
  95. pmc Neural correlates of human action observation in hearing and deaf subjects
    David Corina
    Department of Psychology, University of Washington, Seattle, USA Center for Mind and Brain, University of California, Davis, USA
    Brain Res 1152:111-29. 2007
    ..However, the results indicate that this neural consistency across motion classes is true primarily for hearing subjects. Data from deaf signers shows a non-uniform response to different classes of human actions...
  96. pmc Orphan glutamate receptor delta1 subunit required for high-frequency hearing
    Jiangang Gao
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Cell Biol 27:4500-12. 2007
    ..Our findings show that the orphan GluRdelta1 plays an essential role in high-frequency hearing and ionic homeostasis in the basal cochlea, and the locus encoding GluRdelta1 represents a candidate gene for ..
  97. ncbi Evaluation of the relation between audiometric and psychometric measures of hearing after tympanoplasty
    Astrid G W Korsten-Meijer
    Department of Otorhinolaryngology, University Hospital Groningen, Groningen, The Netherlands
    Eur Arch Otorhinolaryngol 263:256-62. 2006
    ..b>Hearing (dis)ability was measured by means of pure-tone audiometry and a validated self-assessment questionnaire: the (..
  98. ncbi A prospective study on radiation-induced changes in hearing function
    Franziska Herrmann
    Department of Oto Rhino Laryngology, University of Technology Dresden, Dresden, Germany
    Int J Radiat Oncol Biol Phys 65:1338-44. 2006
    To quantitate changes in hearing function after radiotherapy for head-and-neck tumors.
  99. ncbi Social cognition as a mediator of cognition and outcome among deaf and hearing people with schizophrenia
    Heather K Horton
    School of Social Welfare, University at Albany, Richardson Hall 280, 135 Western, Avenue, Albany, NY 12203, United States
    Schizophr Res 105:125-37. 2008
    ..The current project tests the mediating potency of these two domains of social cognition among deaf and hearing people with schizophrenia...
  100. pmc Measuring hearing organ vibration patterns with confocal microscopy and optical flow
    Anders Fridberger
    Center for Hearing and Communication Research and Department of Otolaryngology, Karolinska Institutet, Stockholm, Sweden
    Biophys J 86:535-43. 2004
    ..These methods were used for investigating the motion pattern of the vibrating hearing organ...
  101. doi Vibratory interneurons in the non-hearing cave cricket indicate evolutionary origin of sound processing elements in Ensifera
    Natasa Stritih
    National Institute of Biology, Department of Entomology, Vecna pot 111, SI 1000 Ljubljana, Slovenia
    Zoology (Jena) 112:48-68. 2009
    Tympanal hearing organs in the front tibiae of ensiferan insects supposedly evolved from vibration-sensitive tibial organs (TO), like those in the cave cricket Troglophilus neglectus (Rhaphidophoridae)...

Research Grants97

  1. Can L-carnitine prevent drug-induced hearing loss?
    Gilda Kalinec; Fiscal Year: 2004
    b>Hearing loss is a prevalent and chronic health condition that affects between 22 and 28 million Americans...
  2. Characterization of Hearing Status in the Jackson Heart Study Cohort
    John Schweinfurth; Fiscal Year: 2007
    The contribution of cardiovascular disease (CVD) to the development of sensorineural hearing loss (SNHL) is not well understood. The cochlea is known to be very sensitive to ischemia...
  3. Evaluation of Hearing Loss in Farmworkers, Texas- Mexico Border Area
    Martha S Vela Acosta; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Occupational hearing loss is the most common occupational disease in the United States. It affects all workers regardless of age, gender, or industrial sector...
  4. Cloning & Functional Studies of Deafness Mutations
    Kenneth R Johnson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The mouse is an excellent model for studying human hearing disorders because of the similarities in inner ear anatomy, function, and pathology...
  5. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  6. Effects of Sensorineural Hearing Loss on Robust Speech Coding
    Michael Heinz; Fiscal Year: 2009
    A great challenge in diagnosing and treating hearing impairment comes from the fact that people with similar degrees of hearing loss may have different speech recognition abilities...
  7. Effects of Sensorineural Hearing Loss on Robust Speech Coding
    Michael G Heinz; Fiscal Year: 2010
    A great challenge in diagnosing and treating hearing impairment comes from the fact that people with similar degrees of hearing loss may have different speech recognition abilities...
  8. DEAFNESS AND OSSIFICATION IN LABYRINTHITIS OSSIFICANS
    Hilary Brodie; Fiscal Year: 2003
    ..It is multifactorial in origin and may result in deafness. Profound hearing loss and LO in children are most commonly associated with meningogenic labyrinthitis...
  9. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    DOUGLAS KEEFE; Fiscal Year: 2009
    ..Monitoring of Middle-Ear and Cochlear Function A wideband (WB) acoustic test battery has the potential to improve hearing screening and diagnosis of middle-ear and cochlear dysfunction across the age range...
  10. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    DOUGLAS KEEFE; Fiscal Year: 2009
    ..Monitoring of Middle-Ear and Cochlear Function A wideband (WB) acoustic test battery has the potential to improve hearing screening and diagnosis of middle-ear and cochlear dysfunction across the age range...
  11. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    DOUGLAS H contact KEEFE; Fiscal Year: 2010
    ..Monitoring of Middle-Ear and Cochlear Function A wideband (WB) acoustic test battery has the potential to improve hearing screening and diagnosis of middle-ear and cochlear dysfunction across the age range...
  12. Pilot Study: Self Management Groups for Veterans with Dual Sensory Loss
    MITCHEL BRANT TURBIN; Fiscal Year: 2011
    ..provided by applicant): Project Summary/Abstract The risk that a Veteran will experience concurrent visual and hearing impairments increases with age...
  13. Evaluation of Approaches to Auditory Rehabilitation for Mild TBI
    Gabrielle Saunders; Fiscal Year: 2009
    ..for veterans who have normal/near-normal peripheral auditory function and significant complaints of difficulty hearing. Many are veterans of the OIF/OEF conflicts who have been exposed to blast - the most common wounding etiology in ..
  14. Can L-carnitine prevent drug-induced hearing loss?
    Gilda Kalinec; Fiscal Year: 2002
    b>Hearing loss is a prevalent and chronic health condition that affects between 22 and 28 million Americans...
  15. Can L-carnitine prevent drug-induced hearing loss?
    Gilda Kalinec; Fiscal Year: 2003
    b>Hearing loss is a prevalent and chronic health condition that affects between 22 and 28 million Americans...
  16. Targeting S1P receptors to prevent hearing loss
    Jerold Chun; Fiscal Year: 2010
    Targeting S1P receptors to prevent hearing loss Cochlear hair cells, the primary functional subunits required for the transduction of vibration into the auditory sensation, are subject to irreversible degeneration and consequent loss of ..
  17. Targeting S1P receptors to prevent hearing loss
    Jerold Chun; Fiscal Year: 2009
    Targeting S1P receptors to prevent hearing loss Cochlear hair cells, the primary functional subunits required for the transduction of vibration into the auditory sensation, are subject to irreversible degeneration and consequent loss of ..
  18. Telephone screening test for hearing using three-digit sequences in noise.
    Charles Watson; Fiscal Year: 2009
    This project will develop a speech-recognition test in noise (SRTn) for use as a screening test for hearing disability, suitable for delivery over the telephone...
  19. Telephone screening test for hearing using three-digit sequences in noise.
    Charles Watson; Fiscal Year: 2009
    This project will develop a speech-recognition test in noise (SRTn) for use as a screening test for hearing disability, suitable for delivery over the telephone...
  20. DEVELOPMENT OF A DRUG THERAPY TO AMELIORATE PERMANENT HEARING LOSS
    Jianxin Bao; Fiscal Year: 2011
    ..DESCRIPTION (provided by applicant): Noise is the most common occupational and environmental hazard. Noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit, after age-related hearing loss (..
  21. DEVELOPMENT OF A DRUG THERAPY TO AMELIORATE PERMANENT HEARING LOSS
    Jianxin Bao; Fiscal Year: 2009
    ..DESCRIPTION (provided by applicant): Noise is the most common occupational and environmental hazard. Noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit, after age-related hearing loss (..
  22. Noise-Induced Hearing Loss: Threshold, exposure and genetic susceptibility
    Susan L Phillips; Fiscal Year: 2010
    ..The short-term goal of this R21 Translational Research Grant PAR 06-095 application, entitled "Noise-induced hearing loss: threshold, exposure, and genetic susceptibility," is to establish a basis for identifying people showing a ..
  23. DEVELOPMENT OF A DRUG THERAPY TO AMELIORATE PERMANENT HEARING LOSS
    Jianxin Bao; Fiscal Year: 2010
    ..DESCRIPTION (provided by applicant): Noise is the most common occupational and environmental hazard. Noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit, after age-related hearing loss (..
  24. Determinants of Word Recognition Speed in Older Listeners
    Frederick J Gallun; Fiscal Year: 2011
    ..This problem is common even among older adults who do not have hearing loss...
  25. Brain changes in tinnitus
    Josef P Rauschecker; Fiscal Year: 2010
    ..external stimulus, is perceived by about 15% of the adult population, and about 75% of all patients with hearing loss. It can cause severe suffering, and to date, no reliable cure has been found...
  26. Brain changes in tinnitus
    JOSEF RAUSCHECKER; Fiscal Year: 2009
    ..external stimulus, is perceived by about 15% of the adult population, and about 75% of all patients with hearing loss. It can cause severe suffering, and to date, no reliable cure has been found...
  27. Ear Canal Optical Coherent Tomography System
    PAUL SHNITSER; Fiscal Year: 2010
    ..NIDCD) supports research and development of innovative technologies for improving the quality and utilization of hearing aid devices...
  28. RESEARCH TRAINING IN SPEECH AND HEARING SCIENCES
    Christopher Moore; Fiscal Year: 2001
    DESCRIPTION (from applicant's abstract): Advanced training in the speech, language, and hearing sciences is at a critical point in its short history...
  29. RESEARCH TRAINING IN SPEECH AND HEARING SCIENCES
    Christopher Moore; Fiscal Year: 2003
    DESCRIPTION (from applicant's abstract): Advanced training in the speech, language, and hearing sciences is at a critical point in its short history...
  30. RESEARCH TRAINING IN SPEECH AND HEARING SCIENCES
    Christopher Moore; Fiscal Year: 2005
    DESCRIPTION (from applicant's abstract): Advanced training in the speech, language, and hearing sciences is at a critical point in its short history...
  31. RESEARCH TRAINING IN SPEECH AND HEARING SCIENCES
    Christopher Moore; Fiscal Year: 2002
    DESCRIPTION (from applicant's abstract): Advanced training in the speech, language, and hearing sciences is at a critical point in its short history...
  32. RESEARCH TRAINING IN SPEECH AND HEARING SCIENCES
    Christopher Moore; Fiscal Year: 2004
    DESCRIPTION (from applicant's abstract): Advanced training in the speech, language, and hearing sciences is at a critical point in its short history...
  33. Investigations of Human Auditory Mechanics
    Hideko Heidi Nakajima; Fiscal Year: 2010
    ..provided by applicant): This grant seeks to address important clinical and scientific questions regarding human hearing diseases and their treatment...
  34. Investigations of Human Auditory Mechanics
    Hideko Heidi Nakajima; Fiscal Year: 2011
    ..provided by applicant): This grant seeks to address important clinical and scientific questions regarding human hearing diseases and their treatment...
  35. Hearing Therapies for the Future
    Gabrielle Saunders; Fiscal Year: 2007
    ..The conference objective is to expand understanding and facilitate effective treatment of noise induced hearing loss (NIHL)...
  36. Cholesterol Homeostasis in Auditory Function
    MICHELLE LYNN SEYMOUR; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hearing loss is the most common sensory impairment, affecting 1 to 6 per 1000 newborns, nearly 10% of the adult population and 50% of those over age 75...
  37. Completely Digitizing the Custom-Fit Hearing Aid Shell Manufacturing Process
    STEVEN YI; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The average hearing aid costs $1,500, but prices can go up to $5,000 each. Yet Consumer Reports indicates that 40 percent of hearing aid users are unhappy with their devices...
  38. Genetic hearing screening for newborns
    Xi Lin; Fiscal Year: 2009
    Most states in the United States mandate a universal newborn hearing screening (UNHS) and average coverage rate is ~93% among newborns. However, most of those (>90%) who failed UNHS are false positives...
  39. The Ear-Brain System: Approaches to the Study and Treatment of Hearing Loss
    Gabrielle Saunders; Fiscal Year: 2009
    ..and researchers to discuss and learn about clinical issues associated with improvement of rehabilitation for hearing-impaired individuals...
  40. Wide-bandwidth open canal hearing aid for better multitalker speech understanding
    Sunil Puria; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Our goal is to design and build a new hearing aid system, which mitigates the most common complaints that hearing aid users have...
  41. Wide-bandwidth open canal hearing aid for better multitalker speech understanding
    Sunil Puria; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Our goal is to design and build a new hearing aid system, which mitigates the most common complaints that hearing aid users have...
  42. Gene-Expression Patterns During Hair-Cell Regeneration
    ALBERT HUDSPETH; Fiscal Year: 2009
    ..Deafness and lesser degrees of hearing impairment have an enormous impact on modern societies...
  43. The Impact of Frequency Compression on Cortical Evoked Potentials and Perception
    Benjamin J Kirby; Fiscal Year: 2012
    ..provided by applicant): One of the central challenges in the field of audiology is the verification of optimal hearing aid fitting in infants and young children who cannot reliabl provide detailed subjective feedback about hearing ..
  44. Method of Wind Noise Suppression in Hearing Aids
    GARY ELKO; Fiscal Year: 2007
    ..and refine a promising novel digital technique we have developed at MH Acoustics for reducing wind noise in hearing aids...
  45. Characterization of Hearing Status in the Jackson Heart Study Cohort
    John Schweinfurth; Fiscal Year: 2009
    The contribution of cardiovascular disease (CVD) to the development of sensorineural hearing loss (SNHL) is not well understood. The cochlea is known to be very sensitive to ischemia...
  46. CORE CENTER
    ROBERT DOOLING; Fiscal Year: 2009
    ..goals of the Core Center remain as before to: bring together 17 investigators working on different aspects of hearing and communication disorders, increase the efficiency and productivity of their individual efforts and ongoing ..
  47. Eradication of Occupational Noise-Induced Hearing Loss
    Kevin Michael; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Noise-induced hearing loss remains one of the most common industrial diseases in U.S...
  48. HEARING HAZARD ASSOCIATED WITH INDUSTRIAL NOISE EXPOSURE
    ROGER HAMERNIK; Fiscal Year: 2009
    ..Application of the EEH in many industrial environments severely underestimates hearing loss...
  49. HEARING HAZARD ASSOCIATED WITH INDUSTRIAL NOISE EXPOSURE
    Roger P Hamernik; Fiscal Year: 2010
    ..Application of the EEH in many industrial environments severely underestimates hearing loss...
  50. Understanding thyroid hormone regulation of neurogenesis in the cochlea
    MIRNA MUSTAPHA CHAIB; Fiscal Year: 2010
    b>Hearing impairment is prevalent and has significant implications for quality of life. There are currently no available clinical cures for hereditary inner ear disease or reliable means of preventing age related hearing loss...
  51. Contrast Enhancement to Improve Speech Recognition with Hearing Devices
    Keith Kluender; Fiscal Year: 2009
    ..broad Challenge Area (06): Enabling Technologies and specific Challenge Topic, 06-DC-101: Develop Improved Hearing Devices...
  52. HEARING DAMAGE AMONG NEWLY-HIRED CONSTRUCTION WORKERS
    Noah Seixas; Fiscal Year: 2002
    Noise-induced hearing loss (NIHL) is among the most common occupational afflictions, especially to construction workers...
  53. HEARING DAMAGE AMONG NEWLY-HIRED CONSTRUCTION WORKERS
    Noah Seixas; Fiscal Year: 2001
    Noise-induced hearing loss (NIHL) is among the most common occupational afflictions, especially to construction workers...
  54. Contrast Enhancement to Improve Speech Recognition with Hearing Devices
    Keith R Kluender; Fiscal Year: 2010
    ..broad Challenge Area (06): Enabling Technologies and specific Challenge Topic, 06-DC-101: Develop Improved Hearing Devices...
  55. HEARING DAMAGE AMONG NEWLY-HIRED CONSTRUCTION WORKERS
    Noah Seixas; Fiscal Year: 2003
    Noise-induced hearing loss (NIHL) is among the most common occupational afflictions, especially to construction workers...
  56. Understanding thyroid hormone regulation of neurogenesis in the cochlea
    MIRNA MUSTAPHA CHAIB; Fiscal Year: 2009
    b>Hearing impairment is prevalent and has significant implications for quality of life. There are currently no available clinical cures for hereditary inner ear disease or reliable means of preventing age related hearing loss...
  57. HEARING DAMAGE AMONG NEWLY-HIRED CONSTRUCTION WORKERS
    Noah Seixas; Fiscal Year: 2000
    Noise-induced hearing loss (NIHL) is among the most common occupational afflictions, especially to construction workers...
  58. Understanding thyroid hormone regulation of neurogenesis in the cochlea
    MIRNA MUSTAPHA CHAIB; Fiscal Year: 2009
    b>Hearing impairment is prevalent and has significant implications for quality of life. There are currently no available clinical cures for hereditary inner ear disease or reliable means of preventing age related hearing loss...
  59. Defining Antigenic Targets of Autoimmune Sensorineural Hearing Loss
    Thomas E Carey; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Autoimmune hearing loss (AHL) is a poorly understood disorder that can lead to profound and permanent hearing loss. Inner ear damage in AHL can be antibody mediated or cell mediated...
  60. HEARING DAMAGE AMONG NEWLY-HIRED CONSTRUCTION WORKERS
    Noah Seixas; Fiscal Year: 1999
    Noise-induced hearing loss (NIHL) is among the most common occupational afflictions, especially to construction workers...
  61. Multi-site study of speech perception training for hearing-aid users
    Charles S Watson; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Between 25 and 35% of the adults in the US who could benefit from hearing aids, as many as 25,000,000 persons, either refuse to consider those devices or reject them after a trial...
  62. Multi-site study of speech perception training for hearing-aid users
    Charles S Watson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Between 25 and 35% of the adults in the US who could benefit from hearing aids, as many as 25,000,000 persons, either refuse to consider those devices or reject them after a trial...
  63. High frequency auditory sensitivity in birds
    Bernard Lohr; Fiscal Year: 2004
    ..goal of this research is to advance the understanding of the limitations, diversity, and comparative aspects of hearing in birds...
  64. High frequency auditory sensitivity in birds
    Bernard Lohr; Fiscal Year: 2003
    ..goal of this research is to advance the understanding of the limitations, diversity, and comparative aspects of hearing in birds...
  65. High frequency auditory sensitivity in birds
    Bernard Lohr; Fiscal Year: 2002
    ..goal of this research is to advance the understanding of the limitations, diversity, and comparative aspects of hearing in birds...
  66. Ecological Momentary Assessment in Hearing Disorders
    James Henry; Fiscal Year: 2009
    The two most common auditory disorders among middle-aged Americans are hearing loss and tinnitus...
  67. ANTIBODY INDUCED HEARING LOSS--MODEL FOR IMMUNE DEAFNESS
    Thomas Carey; Fiscal Year: 1999
    Sensorineural hearing loss (SNHL) of unexplained etiology is a common entity with an incidence rate of 1:10,000 for which there are few effective treatments...
  68. TOOTH LOSS AND AGE RELATED HEARING LOSS
    Herenia Lawrence; Fiscal Year: 1999
    This study will evaluate a hypothetical association between tooth loss and age-related hearing loss in health male adults...
  69. Hearing Loss and Aging
    Frank R Lin; Fiscal Year: 2011
    ..amp;Neck Surgery at the Johns Hopkins School of Medicine where his clinical practice is dedicated to hearing loss and otology. He previously completed a Ph...
  70. Development of the Mouse Cochlea Database
    Peter Santi; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Among the 5 senses, hearing is fundamental for acquiring language, communication, and navigating through our environment...
  71. Development of the Mouse Cochlea Database
    Peter Santi; Fiscal Year: 2009
    Among the five senses, hearing is fundamental for acquiring language, communication, and navigating through our environment...
  72. Development of the Mouse Cochlea Database
    PETER ALAN SANTI; Fiscal Year: 2010
    Among the five senses, hearing is fundamental for acquiring language, communication, and navigating through our environment...
  73. CTL2 ELISA: A Diagnostic Test for Autoimmune Hearing Loss
    Vijay Kumar; Fiscal Year: 2007
    unreadable] DESCRIPTION (Provided by applicant): Autoimmune hearing loss (AHL) is a subset of sensorineural hearing loss (SNHL) in which there is a sudden onset, or rapidly progressing and/or fluctuating hearing loss that often ..
  74. Development of the Mouse Cochlea Database
    Peter Santi; Fiscal Year: 2009
    Among the five senses, hearing is fundamental for acquiring language, communication, and navigating through our environment...
  75. EFFECTS OF ASYMMETRIC HEARING IN ACOUSTIC LISTENERS AND COCHLEAR IMPLANT USERS
    Jill Firszt; Fiscal Year: 2009
    ..Many patients function with noticeable asymmetry in hearing. We propose to study the effects of asymmetric hearing in three patient populations...
  76. EFFECTS OF ASYMMETRIC HEARING IN ACOUSTIC LISTENERS AND COCHLEAR IMPLANT USERS
    Jill B Firszt; Fiscal Year: 2010
    ..Many patients function with noticeable asymmetry in hearing. We propose to study the effects of asymmetric hearing in three patient populations...
  77. EFFECTS OF ASYMMETRIC HEARING IN ACOUSTIC LISTENERS AND COCHLEAR IMPLANT USERS
    Jill Firszt; Fiscal Year: 2009
    ..Many patients function with noticeable asymmetry in hearing. We propose to study the effects of asymmetric hearing in three patient populations...
  78. Modeling speech intelligibility in competing backgrounds by the hearing-impaired
    JOSHUA GARY BERNSTEIN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hearing-impaired (HI) listeners are severely disadvantaged in noisy situations...
  79. PHYLOGENY AND ONTOGENY OF AN AUDITORY SYSTEM
    DAVID YAGER; Fiscal Year: 2001
    ..changes occur in the sensory periphery and the CNS during the evolutionary transition between earless and eared (hearing) animals...
  80. PHYLOGENY AND ONTOGENY OF AN AUDITORY SYSTEM
    DAVID YAGER; Fiscal Year: 2003
    ..changes occur in the sensory periphery and the CNS during the evolutionary transition between earless and eared (hearing) animals...
  81. PHYLOGENY AND ONTOGENY OF AN AUDITORY SYSTEM
    DAVID YAGER; Fiscal Year: 2000
    ..changes occur in the sensory periphery and the CNS during the evolutionary transition between earless and eared (hearing) animals...
  82. PHYLOGENY AND ONTOGENY OF AN AUDITORY SYSTEM
    DAVID YAGER; Fiscal Year: 1999
    ..changes occur in the sensory periphery and the CNS during the evolutionary transition between earless and eared (hearing) animals...
  83. PHYLOGENY AND ONTOGENY OF AN AUDITORY SYSTEM
    DAVID YAGER; Fiscal Year: 2004
    ..changes occur in the sensory periphery and the CNS during the evolutionary transition between earless and eared (hearing) animals...
  84. Autoimmune inner ear disease multicenter clinical trial
    Steven Telian; Fiscal Year: 2000
    Autoimmune inner ear disease (AIED), or idiopathic, progressive, bilateral, sensorineural hearing loss (IPBSNHL), is a rapidly progressive form of sensorineural deafness that occurs over weeks to months and affects both ears, usually ..
  85. PHYLOGENY AND ONTOGENY OF AN AUDITORY SYSTEM
    DAVID YAGER; Fiscal Year: 2002
    ..changes occur in the sensory periphery and the CNS during the evolutionary transition between earless and eared (hearing) animals...
  86. Individualized Objective Techniques for Early Detection of Ototoxicity
    MARILYN FARNSWORTH contact DILLE; Fiscal Year: 2011
    ..Unfortunately, cisplatin can produce cochlear damage resulting in irreversible hearing loss if treatment continues...
  87. Spontaneous Sign Systems in Five Cultures
    Susan Goldin Meadow; Fiscal Year: 2009
    ..The participants are deaf children whose hearing parents have not yet exposed them to sign language, and whose hearing losses are so profound as to preclude ..
  88. Spontaneous Sign Systems in Five Cultures
    Susan Goldin Meadow; Fiscal Year: 2007
    ..The participants are deaf children whose hearing parents have not yet exposed them to sign language, and whose hearing losses are so profound as to preclude ..
  89. Spontaneous Sign Systems in Five Cultures
    SUSAN J GOLDIN MEADOW; Fiscal Year: 2010
    ..The participants are deaf children whose hearing parents have not yet exposed them to sign language, and whose hearing losses are so profound as to preclude ..
  90. The Role of Eya4 in Hearing and Disease
    Jonathan Seidman; Fiscal Year: 2006
    ..Mutations in the transcriptional co-activator EYA4 are responsible for autosomal dominant sensorineural hearing loss at the DFNA10 locus. Mice carrying mutant Eya4 alleles provide a model of human hearing loss...
  91. Spontaneous Sign Systems in Five Cultures
    Susan Goldin Meadow; Fiscal Year: 2006
    ..The participants are deaf children whose hearing parents have not yet exposed them to sign language, and whose hearing losses are so profound as to preclude ..
  92. Molecular mechanisms of auditory nAChR synapse assembly
    Michele Jacob; Fiscal Year: 2009
    Sensorineural hearing loss affects 30 million Americans. Aging, noise-overexposure, infection and ototoxic antibiotics all lead to sensory hair cell degeneration and permanent hearing loss...
  93. Understanding Noise-Induced Delayed Primary Degeneration of the Auditory Nerve
    Konstantina M Stankovic; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Noise-induced hearing loss is a problem of profound clinical significance, growing magnitude, and major societal impact, because opportunities for overexposure abound, and exposures that damage ..
  94. Understanding Noise-Induced Delayed Primary Degeneration of the Auditory Nerve
    Konstantina M Stankovic; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Noise-induced hearing loss is a problem of profound clinical significance, growing magnitude, and major societal impact, because opportunities for overexposure abound, and exposures that damage ..
  95. Effectiveness of an Intervention to Prevent Hearing Loss Among Farmers
    Marjorie C McCullagh; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Hearing loss and tinnitus are prevalent in America, and noise exposure is a leading cause of hearing loss. This type of hearing loss is known as Noise-Induced Hearing Loss (NIHL)...
  96. OTITIS MEDIA & SCHOOL OUTCOMES--ENVIRONMENTAL MEDIATORS
    Joanne Roberts; Fiscal Year: 2000
    ..Considerable controversy surrounds whether a history of OME and associated hearing loss causes language, auditory processing, and later learning problems...
  97. Rescue of cortical inhibitory synapses following developmental hearing loss
    Vibhakar C Kotak; Fiscal Year: 2011
    ..this idea, cortical inhibitory synapse strength is reduced dramatically following even moderate developmental hearing loss. However, whether inhibitory synapse maturation displays a critical period is poorly understood...