self stimulation

Summary

Summary: Stimulation of the brain, which is self-administered. The stimulation may result in negative or positive reinforcement.

Top Publications

  1. ncbi Effects of central leptin infusion on the reward-potentiating effect of D-amphetamine
    Joy Hao
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Brain Res 1087:123-33. 2006
  2. ncbi Nicotinic acetylcholine alpha4beta2 receptor regulates the motivational effect of intracranial self stimulation behavior in the runway method
    Hidenori Sagara
    Department of Pharmaceutical Information Sciences, Matsuyama University, Japan
    J Pharmacol Sci 108:455-61. 2008
  3. ncbi Real time measurement of stimulated dopamine release in the conscious rat using fast cyclic voltammetry: dopamine release is not observed during intracranial self stimulation
    Z L Kruk
    Department of Pharmacology, Queen Mary and Westfield College, London, UK
    J Neurosci Methods 79:9-19. 1998
  4. ncbi WIN 55,212-2 decreases the reinforcing actions of cocaine through CB1 cannabinoid receptor stimulation
    Styliani Vlachou
    Division of Biopsychology, Laboratory of Neurosciences and Behavior, Department of Psychology, School of Social Sciences, University of Crete, 74100 Rethymnon, Crete, Greece
    Behav Brain Res 141:215-22. 2003
  5. ncbi Paroxetine combined with a 5-HT(1A) receptor antagonist reversed reward deficits observed during amphetamine withdrawal in rats
    Athina Markou
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 178:133-42. 2005
  6. ncbi Mesencephalic substrate of reward: lesion effects
    Sandra M Boye
    Centre de Recherche Fernand Seguin, Hopital Louis H Lafontaine, 7331 Hochelaga, Montreal, Que, Canada H1N 3V2
    Behav Brain Res 156:31-43. 2005
  7. ncbi Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats
    Paul J Kenny
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 179:247-54. 2005
  8. ncbi CB1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat
    Styliani Vlachou
    Laboratory of Behavioral Neuroscience, Department of Psychology, School of Social Sciences, University of Crete, 74100 Rethymnon, Crete, Greece
    Psychopharmacology (Berl) 179:498-508. 2005
  9. ncbi The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat
    David A Slattery
    Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Neuropsychopharmacology 30:2065-72. 2005
  10. ncbi Slower extinction of responses maintained by intra-cranial self-stimulation (ICSS) in an animal model of attention-deficit/hyperactivity disorder (ADHD)
    Espen Borgå Johansen
    Department of Physiology, University of Oslo, Norway Centre for Advanced Study, P O Box 1103 Blindern, 0317 Oslo, Norway
    Behav Brain Res 162:22-31. 2005

Research Grants

  1. DYNAMICS OF IN VIVO DOPAMINE RELEASE
    Robert Wightman; Fiscal Year: 2007
  2. Role of noncoding RNAs in schizophrenia
    Claes Wahlestedt; Fiscal Year: 2009
  3. Modulators of Metabotropic Glutamate Receptor Subtype 2 for Cocaine Dependence
    Nicholas Cosford; Fiscal Year: 2009
  4. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2009
  5. Adolescent Alcohol,Dysregulated Stress System, and PTSD Vulnerability
    GERHARD SCHULTEIS; Fiscal Year: 2009
  6. Endocannabinoid Discrimination
    Jenny L Wiley; Fiscal Year: 2010
  7. DRUGS OF ABUSE, DOPAMINE & CONTROL BY BRAIN PEPTIDES
    BARTLEY HOEBEL; Fiscal Year: 1990
  8. Combined Voltammetry/Electrophysiology in Behaving Rats
    Regina M Carelli; Fiscal Year: 2010
  9. Role of noncoding RNAs in schizophrenia
    CLAES ROBERT WAHLESTEDT; Fiscal Year: 2011
  10. Role of noncoding RNAs in schizophrenia
    CLAES ROBERT contact WAHLESTEDT; Fiscal Year: 2010

Detail Information

Publications175 found, 100 shown here

  1. ncbi Effects of central leptin infusion on the reward-potentiating effect of D-amphetamine
    Joy Hao
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Brain Res 1087:123-33. 2006
    ..Together, results of this study support the importance of weight loss, but not leptin, in the enhancement of drug reward sensitivity...
  2. ncbi Nicotinic acetylcholine alpha4beta2 receptor regulates the motivational effect of intracranial self stimulation behavior in the runway method
    Hidenori Sagara
    Department of Pharmaceutical Information Sciences, Matsuyama University, Japan
    J Pharmacol Sci 108:455-61. 2008
    ..These results demonstrate that nicotine enhances the running speed towards the goal lever via alpha4beta2 nicotinic receptors and suggest that alpha4beta2 nicotinic receptors influence the brain mechanism of motivation...
  3. ncbi Real time measurement of stimulated dopamine release in the conscious rat using fast cyclic voltammetry: dopamine release is not observed during intracranial self stimulation
    Z L Kruk
    Department of Pharmacology, Queen Mary and Westfield College, London, UK
    J Neurosci Methods 79:9-19. 1998
    ..Rats trained on a continuous reinforcement schedule to perform intracranial self stimulation (ICSS) were implanted with electrodes for FCV...
  4. ncbi WIN 55,212-2 decreases the reinforcing actions of cocaine through CB1 cannabinoid receptor stimulation
    Styliani Vlachou
    Division of Biopsychology, Laboratory of Neurosciences and Behavior, Department of Psychology, School of Social Sciences, University of Crete, 74100 Rethymnon, Crete, Greece
    Behav Brain Res 141:215-22. 2003
    ....
  5. ncbi Paroxetine combined with a 5-HT(1A) receptor antagonist reversed reward deficits observed during amphetamine withdrawal in rats
    Athina Markou
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 178:133-42. 2005
    ..2001)...
  6. ncbi Mesencephalic substrate of reward: lesion effects
    Sandra M Boye
    Centre de Recherche Fernand Seguin, Hopital Louis H Lafontaine, 7331 Hochelaga, Montreal, Que, Canada H1N 3V2
    Behav Brain Res 156:31-43. 2005
    ....
  7. ncbi Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats
    Paul J Kenny
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 179:247-54. 2005
    ..Evidence is accumulating that metabotropic glutamate 5 (mGlu5) receptors play an important role in regulating the reinforcing actions of drugs of abuse...
  8. ncbi CB1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat
    Styliani Vlachou
    Laboratory of Behavioral Neuroscience, Department of Psychology, School of Social Sciences, University of Crete, 74100 Rethymnon, Crete, Greece
    Psychopharmacology (Berl) 179:498-508. 2005
    ..However, cannabinoids appear atypical as drugs of abuse, since there are controversial data in the literature concerning their reinforcing properties...
  9. ncbi The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat
    David A Slattery
    Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Neuropsychopharmacology 30:2065-72. 2005
    ..Therefore, GABAB-positive modulation may represent a novel therapeutic strategy for the treatment of cocaine dependence and possibly other drugs of abuse without the side effects of full GABAB receptor agonists...
  10. ncbi Slower extinction of responses maintained by intra-cranial self-stimulation (ICSS) in an animal model of attention-deficit/hyperactivity disorder (ADHD)
    Espen Borgå Johansen
    Department of Physiology, University of Oslo, Norway Centre for Advanced Study, P O Box 1103 Blindern, 0317 Oslo, Norway
    Behav Brain Res 162:22-31. 2005
    ..Slower extinction of previously reinforced behavior is suggested as an alternative explanation for the frequently observed increased behavioral output that has previously been interpreted as "disinhibition" of behavior in ADHD...
  11. ncbi Neural correlates to action and rewards in the rat posterior cingulate cortex
    Eiichi Tabuchi
    System Emotional Science, Graduate School of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930 0194, Japan
    Neuroreport 16:949-53. 2005
    ..The present results and comparison with previous studies on the anterior cingulate cortex suggest that the posterior cingulate cortex is involved in the monitoring or storage of action-reward outcome association...
  12. ncbi Short- and long-term effects of interleukin-2 on weight, food intake, and hedonic mechanisms in the rat
    M Miguelez
    School of Psychology, University of Ottawa, Ottawa, K1N 6N5, Canada
    Behav Brain Res 154:311-9. 2004
    ..We further suggest that since this modulation appears to be notably site-specific, IL-2 receptors or its metabolites may not be evenly distributed within the medial forebrain bundle...
  13. ncbi The basolateral complex of the amygdala mediates the modulation of intracranial self-stimulation threshold by drug-associated cues
    Robert J Hayes
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Dr, Baltimore, Maryland 21224, USA
    Eur J Neurosci 20:273-80. 2004
    ..We conclude that the BLC is necessary for cues associated with previous drug exposure to modulate activity within or downstream from the classical reward circuitry of the medial forebrain bundle...
  14. ncbi Mapping the neural substrate underlying brain stimulation reward with the behavioral adaptation of double-pulse methods
    Maia Miguelez
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
    Rev Neurosci 15:47-74. 2004
    ..Attention is drawn to the major contribution of these methods to our understanding of the neural pathways and characteristics underlying BSR...
  15. ncbi A progressive ratio schedule of self-stimulation testing in rats reveals profound augmentation of d-amphetamine reward by food restriction but no effect of a "sensitizing" regimen of d-amphetamine
    Soledad Cabeza de Vaca
    Department of Psychiatry Millhauser Laboratories, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 175:106-13. 2004
    ....
  16. ncbi A new rat model of the human serial reaction time task: contrasting effects of caudate and hippocampal lesions
    Michael A Christie
    Center for Aging Genetics and Neurodegeneration, Department of Neurology, Massachusetts General Hospital and Harvard School of Medicine, Boston, Massachusetts 02129, USA
    J Neurosci 24:1034-9. 2004
    ..By contrast, rats with dorsal hippocampal lesions showed an interference effect at all sequence lengths. This new rat SRT model clarifies the basal ganglia-limbic system dichotomy suggested by human work...
  17. ncbi Exposure of mice to a predator odor increases acoustic startle but does not disrupt the rewarding properties of VTA intracranial self-stimulation
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Brain Res 982:195-210. 2003
    ..Moreover, the anxiogenic properties of psychogenic stressors can be separated from their anhedonic effects. The implications of these data for clinical psychopathology are discussed...
  18. ncbi Roles of pedunculopontine tegmental cholinergic receptors in brain stimulation reward in the rat
    J Chen
    Department of Psychology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192, Japan
    Psychopharmacology (Berl) 184:514-22. 2006
    ..However, to date there is little direct evidence to support this hypothesis...
  19. ncbi Withdrawal from chronic amphetamine induces depressive-like behavioral effects in rodents
    John F Cryan
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:49-58. 2003
    ....
  20. ncbi Effects of naloxone on rewarding and aversive brain sites
    Catherine Bielajew
    School of Psychology, University of Ottawa, Ont, Ottawa, Canada K1N 6N5
    Behav Brain Res 143:75-83. 2003
    ..These findings are discussed in terms of a dissociation between the analgesic and rewarding properties of ventral tegmental area stimulation...
  21. ncbi Facilitation of electrical brain self-stimulation behavior by abused solvents
    Anton Bespalov
    Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg 197089, Russia
    Pharmacol Biochem Behav 75:199-208. 2003
    ..Data from intracranial self-stimulation studies of solvents may be useful in abuse potential assessment of individual compounds and for examining neural and behavioral processes involved in inhalant abuse...
  22. ncbi Prolonged nicotine exposure does not alter GABA(B) receptor-mediated regulation of brain reward function
    Neil E Paterson
    Department of Molecular and Integrative Neuroscience, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 49:953-62. 2005
    ....
  23. ncbi Facilitation of brain stimulation reward by MK-801 (dizocilpine) may be independent of D2-like dopamine receptor stimulation in rats
    R L H Clements
    Department of Psychiatry, and Centre for Neuroscience, University of Alberta, Edmonton, Alberta, T6G 2B7, Canada
    Psychopharmacology (Berl) 182:65-74. 2005
    ..We have recently demonstrated synergistic effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor blockade and D(2/3) DA receptor stimulation in brain stimulation reward (BSR)...
  24. ncbi Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice
    G I Elmer
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Maple and Locust Streets, Baltimore, MD 21228, USA
    Psychopharmacology (Berl) 182:33-44. 2005
    ..Genetically engineered animal models provide a complementary approach to pharmacological investigations...
  25. ncbi Motivational effect of nomifensine in the intracranial self-stimulation behavior using a runway method
    Hidenori Sagara
    Department of Hospital Pharmacy, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Biol Pharm Bull 31:1036-40. 2008
    ..Previously, priming stimulation in the runway method was found to affect motivational function of ICSS. Therefore, our findings suggest the possible application of nomifensine for improving motivation...
  26. doi Consistent rewarding or aversive effects of the electrical stimulation of the lateral parabrachial complex
    Maria J Simon
    Psychobiology, University of Granada, Campus de Cartuja s n, Granada, Spain
    Behav Brain Res 190:67-73. 2008
    ..Therefore, the activation of aversive or rewarding systems may depend on the precise location of the electrode implanted in the LPBe of each animal...
  27. ncbi Motivational effects of methamphetamine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior
    Hidenori Sagara
    Department of Hospital Pharmacy, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Biol Pharm Bull 31:541-5. 2008
    ..These results suggest that the runway method using priming stimulation of ICSS behavior may be an effective way to evaluate the enhancing effect of a drug on motivation...
  28. ncbi Dopamine tone increases similarly during predictable and unpredictable administration of rewarding brain stimulation at short inter-train intervals
    Giovanni Hernandez
    Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    Behav Brain Res 188:227-32. 2008
    ..This finding is consistent with the idea that tonic DA signaling is insensitive to the predictability of rewards...
  29. ncbi Self-stimulation rewarding experience restores stress-induced CA3 dendritic atrophy, spatial memory deficits and alterations in the levels of neurotransmitters in the hippocampus
    K Ramkumar
    Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Hosur Road, PB 2900, Bangalore, 560 029, Karnataka, India
    Neurochem Res 33:1651-62. 2008
    ..We propose that SS rewarding behavioral experience ameliorates the stress-induced cognitive deficits by inducing structural and biochemical changes in the hippocampus...
  30. ncbi Predictable and unpredictable rewards produce similar changes in dopamine tone
    Giovanni Hernandez
    Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, PQ, Canada
    Behav Neurosci 121:887-95. 2007
    ..Nonetheless, indistinguishable changes in DA concentration were observed in the 2 groups. Thus, reward predictability had no discernable effect on a measure believed to track the slower components of DA signaling...
  31. pmc Prenatal exposure to cocaine increases the rewarding potency of cocaine and selective dopaminergic agonists in adult mice
    C J Malanga
    Laboratory of Molecular and Developmental Neuroscience, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 63:214-21. 2008
    ..Animal models of prenatal cocaine exposure have yielded differing results depending on the behavioral method used to assess drug potency...
  32. pmc Brain stimulation reward is integrated by a network of electrically coupled GABA neurons
    Matthew B Lassen
    Brigham Young University, Provo, UT 84602, USA
    Brain Res 1156:46-58. 2007
    ..Thus, a network of electrically coupled GABA neurons in the ventral brain may form the elusive neural integrator of BSR...
  33. ncbi Medial forebrain bundle stimulation evokes endocannabinoid-mediated modulation of ventral tegmental area dopamine neuron firing in vivo
    Giuliano Pillolla
    B B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, 09042, Monserrato, Cagliari, Italy
    Psychopharmacology (Berl) 191:843-53. 2007
    ..However, their functional and/or behavioural correlates are yet to be determined...
  34. ncbi Investigating the hedonic effects of interferon-alpha on female rats using brain-stimulation reward
    Amanda C Kentner
    School of Psychology, University of Ottawa, Ottawa, Canada K1N 6N5
    Behav Brain Res 177:90-9. 2007
    ..This pattern was also evident in the overall total sickness behaviour scores. Our data suggest that a single exposure to IFN-alpha treatment in female rats elicits long-term somatic effects, without altering hedonic status...
  35. ncbi [Effects of antidepressants in models of brain self-stimulation and place preference after prolong social isolation and alcoholization]
    P D Shabanov
    Eksp Klin Farmakol 69:60-5. 2006
    ..It is concluded that antidepressants studied activate the reinforcing properties of the brain, that is associated with the involvement of both the catecholamine and serotonin system, working reciprocally...
  36. ncbi Heroin addiction: anticipating the reward of heroin or the agony of withdrawal?
    Magalie Lenoir
    Laboratoire de Neuropsychobiologie, Universite Victor Segalen Bordeaux 2, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5541, 33076 Bordeaux, France
    J Neurosci 26:9080-1. 2006
  37. ncbi Effects of endocannabinoid neurotransmission modulators on brain stimulation reward
    Styliani Vlachou
    Laboratory of Behavioral Neuroscience, Department of Psychology, School of Social Sciences, University of Crete, 74100 Rethymnon, Crete, Greece
    Psychopharmacology (Berl) 188:293-305. 2006
    ..However, the relevant studies concerning the ability of endocannabinoid modulators to modify reward processes in experimental animals remain rather scarce...
  38. ncbi Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists
    Anton Bespalov
    Institute of Pharmacology, IP Pavlov Medical University, St Petersburg, Russia
    Behav Pharmacol 17:295-302. 2006
    ..These results indicate that, within a limited dose range, caffeine in combination with an NMDA receptor channel blocker and a competitive antagonist significantly lowers brain stimulation reward thresholds in rats...
  39. ncbi Two brain sites for cannabinoid reward
    Abraham Zangen
    National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 26:4901-7. 2006
    ..These findings link the sites of rewarding action of Delta9THC to brain regions where such drugs as amphetamines, cocaine, heroin, and nicotine are also thought to have their sites of rewarding action...
  40. ncbi Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction
    Laura E O'Dell
    Molecular and Integrative Neuroscience Department, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 186:612-9. 2006
    ..Enhanced reinforcing effects of nicotine during adolescence appear to contribute to the rapid development of dependence in this age group. However, the contribution of nicotine withdrawal to dependence in adolescents is unclear...
  41. pmc Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats
    Daria Rylkova
    Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
    Neuropeptides 42:215-27. 2008
    ..In addition, NPY decreases the sensitivity to rewarding electrical stimuli via an Y1 dependent mechanism...
  42. ncbi The effects of ventral tegmental administration of GABA(A), GABA(B), NMDA and AMPA receptor agonists on ventral pallidum self-stimulation
    George Panagis
    University of Crete, School of Social Sciences, Department of Psychology, Crete, Rethymnon, Greece
    Behav Brain Res 131:115-23. 2002
    ..The decreased rewarding efficacy of VP self-stimulation following intrategmental injections of muscimol and baclofen may be due to GABAergic modulation of ventral tegmental dopaminergic and nondopaminergic neurons projecting to the VP...
  43. ncbi A cellular mechanism of reward-related learning
    J N Reynolds
    The Neuroscience Research Centre, University of Otago, School of Medical Sciences, Dunedin, New Zealand
    Nature 413:67-70. 2001
    ..We propose that stimulation of the substantia nigra when the lever is pressed induces a similar potentiation of cortical inputs to the striatum, positively reinforcing the learning of the behaviour by the rats...
  44. ncbi Does neuropeptide Y contribute to the modulation of brain stimulation reward by chronic food restriction?
    Stephanie Fulton
    Center for Studies in Behavioural Neurobiology, Concordia University, Hall Building Rm 1013, 1455 de Maisonneuve Blvd, Montreal QC, Canada H3G 1M8
    Behav Brain Res 134:157-64. 2002
    ..These findings suggest that NPY does not take part in the process whereby food restriction and leptin modulate reward circuitry activated by stimulating restriction-sensitive sites...
  45. ncbi Contrasting effects of dopamine antagonists and frequency reduction on Fos expression induced by lateral hypothalamic stimulation
    Glenn E Hunt
    Department of Psychological Medicine, University of Sydney, Concord Hospital, Concord, NSW 2139, Australia
    Behav Brain Res 132:187-201. 2002
    ..These results reveal the utility of Fos immunohistochemistry to show how different treatments that alter the rewarding impact of electrical brain stimulation achieve their effects at the neural level...
  46. ncbi Measuring threshold shifts for brain stimulation reward using the method of limits
    A T Konkle
    University of Ottawa
    Can J Exp Psychol 55:253-60. 2001
    ..Our findings suggest that the threshold procedure is generally not influenced by the sequence of delivery of stimulus values and, thus, may be regarded as a reliable measure of the reinforcing properties of brain-stimulation reward...
  47. ncbi Exposure to chronic mild stress alters thresholds for lateral hypothalamic stimulation reward and subsequent responsiveness to amphetamine
    D Lin
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torry Pines Road, La Jolla, CA 92037, USA
    Neuroscience 114:925-33. 2002
    ..These findings support the hypothesis that prior exposure to stress affects the vulnerability for drug-taking behavior by increasing the positive reinforcing properties of drug of abuse...
  48. ncbi Increase in accumbal dopaminergic transmission correlates with response cost not reward of hypothalamic stimulation
    Darryl B Neill
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Behav Brain Res 137:129-38. 2002
    ....
  49. ncbi Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for "free chow" and "earned" sucrose intake
    Zul Merali
    Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Canada
    Psychopharmacology (Berl) 165:413-8. 2003
    ..Analysis of the behavioral effects of interleukin-1beta (IL-1beta), and their modification by antidepressants, is complicated since the anorexic and anhedonic effects of the cytokine are not readily dissociated from one another...
  50. ncbi Factors that influence the persistence of stimulation-induced aversion
    M Diotte
    School of Psychology, University of Ottawa, 145 Jean-Jacques Lussier Street, P.O. Box 450, Station A, K1N 6N5, Ottawa, Ontario, Canada
    Physiol Behav 72:661-7. 2001
    ..One interpretation of these findings is that the aversion mechanisms associated with the Gi and DTg are differentially susceptible to analgesic processes...
  51. ncbi Ameliorative effects of a cognitive enhancer, T-588, on place learning deficits induced by transient forebrain ischemia in rats
    Y Nakada
    Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan
    Physiol Behav 74:227-35. 2001
    ..These results suggested that T-588 has ameliorative effects on learning deficits induced by brain ischemia, which could be produced through enhancement of residual cognitive functions...
  52. ncbi Motivational effects of nicotine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior
    Hidenori Sagara
    Department of Pharmacy, Okayama University Hospital, Okayama, Japan
    Acta Med Okayama 62:227-33. 2008
    ..The runway method using priming stimulation of ICSS behavior may become the new experimental methodology with which to measure the motivational effect of some drugs...
  53. ncbi The 5-HT3 antagonist Y-25130 blocks cocaine-induced lowering of ICSS reward thresholds in the rat
    Stephen P Kelley
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, Dundee, DD1 9SY Scotland, UK
    Pharmacol Biochem Behav 74:297-302. 2003
    ..3 and 3.0 mg/kg) did attenuate the threshold-lowering effect of cocaine. These findings suggest that the rewarding effects of cocaine are mediated through 5-HT(3) receptor activity...
  54. ncbi Histochemical mapping of the substrate for brain-stimulation reward with glycogen phosphorylase
    A T Konkle
    School of Psychology, University of Ottawa, Ont, Canada
    J Neurosci Methods 93:111-9. 1999
    ....
  55. ncbi In rats, acute morphine dependence results in antagonist-induced response suppression of intracranial self-stimulation
    Keith W Easterling
    Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA, USA
    Psychopharmacology (Berl) 175:287-95. 2004
    ..Lower (0.001-1.0 mg/kg) doses of the opioid antagonist naltrexone produce few behavioral effects in otherwise drug-free rats responding for ICSS, but reduce response rates by up to 75% after a single dose of morphine...
  56. ncbi Accidental death due to complete autoerotic asphyxia associated with transvestic fetishism and anal self-stimulation - case report
    Tatjana Atanasijevic
    Institute of Forensic Medicine, School of Medicine, Belgrade, Serbia
    Psychiatr Danub 21:246-51. 2009
    ....
  57. ncbi Opposite effects of ibotenic acid and 6-hydroxydopamine lesions of the lateral hypothalamus on intracranial self-stimulation and stimulation-induced locomotion
    L Velley
    CNRS UA 339, Talence, France
    Neuroscience 25:595-603. 1988
    ..Furthermore, the brains of two rats unilaterally injected with the usual dose of 6-hydroxydopamine were processed for tyrosine hydroxylase immunocytochemistry.(ABSTRACT TRUNCATED AT 250 WORDS)..
  58. ncbi Blood pressure changes during sexual stimulation, ejaculation and midodrine treatment in men with spinal cord injury
    Frédérique J Courtois
    Department of Sexology, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    BJU Int 101:331-7. 2008
    ....
  59. ncbi Effects of the D(3) dopamine receptor antagonist, U99194A, on brain stimulation and d-amphetamine reward, motor activity, and c-fos expression in ad libitum fed and food-restricted rats
    K D Carr
    Department of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 163:76-84. 2002
    ..However, the locations of the D(3) receptors that regulate behavior, and the range of behavioral functions regulated, are not clear...
  60. ncbi Role of dopamine in the behavioural actions of nicotine related to addiction
    G Di Chiara
    Department of Toxicology and CNR Center of Neuropharmacology, University of Cagliari, Viale Diaz 182, 09100 Cagliari, Italy
    Eur J Pharmacol 393:295-314. 2000
    ..Unavailability of tobacco disrupts the automatic, implicit modality of abnormal habit responding switching responding into the explicit, conscious modality of incentive drug-seeking and craving...
  61. ncbi Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats
    Adrie W Bruijnzeel
    Molecular and Integrative Neuroscience Department, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 1058:91-100. 2005
    ....
  62. doi Chronic bupropion differentially alters the reinforcing, reward-enhancing and conditioned motivational properties of nicotine in rats
    Neil E Paterson
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Nicotine Tob Res 10:995-1008. 2008
    ..Rather, preclinical investigations suggest that bupropion attenuates nicotine-induced enhancement of brain reward function and reverses the anhedonic, somatic, and neurochemical correlates of nicotine withdrawal...
  63. ncbi Alcohol, cocaine, and brain stimulation-reward in C57Bl6/J and DBA2/J mice
    Eric W Fish
    Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Alcohol Clin Exp Res 34:81-9. 2010
    ..These experiments had 2 objectives: first, to establish the effects of alcohol on ICSS responding in the C57Bl6/J (C57) and DBA2/J (DBA) mouse strains; and second, to compare these effects to those of the psychostimulant cocaine...
  64. pmc Attention deficits and hyperactivity following inhibition of cAMP-dependent protein kinase within the medial prefrontal cortex of rats
    Tracie A Paine
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 34:2143-55. 2009
    ..These studies indicate that PKA inhibition within the mPFC of rats produces inattention and hyperactivity, and thus might be useful in modeling human attention disorders...
  65. doi Excitability and gap junction-mediated mechanisms in nucleus accumbens regulate self-stimulation reward in rats
    L Kokarovtseva
    Neuroscience and Mental Health Programme and Brain and Behaviour Centre, Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada M5G1X8
    Neuroscience 159:1257-63. 2009
    ..Thus, the Acb provides a site for the study of pleasure/reward, addiction and conscious experience...
  66. pmc Dopamine signals for reward value and risk: basic and recent data
    Wolfram Schultz
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
    Behav Brain Funct 6:24. 2010
    ..This review provides an updated overview about the basic signals of dopamine neurons to environmental stimuli...
  67. doi Route of administration affects the ability of naltrexone to reduce amphetamine-potentiated brain stimulation reward in rats
    Mark S Todtenkopf
    Department of Life Sciences and Toxicology, Alkermes, Inc, USA
    Addict Biol 14:408-18. 2009
    ..In summary, an extended-release formulation of naltrexone results in significant attenuation of psychostimulant-enhanced BSR that is not observed with acute naltrexone...
  68. ncbi Locomotion induced by non-contingent intracranial stimulation: comparison to psychomotor stimulant
    Valeri Farmer-Dougan
    Departments of Psychology and Biological Sciences, Illinois State University, Normal, IL 61790 4620, USA
    Behav Processes 67:245-61. 2004
    ..The results suggest that locomotion elicited by nEAS was stereotypic, dependent upon DA release and similar, but not identical, to psychomotor stimulant-induced locomotion...
  69. ncbi The effects of buprenorphine on fentanyl withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, 100 S Newell Dr, 100256, Gainesville, FL 32610 0244, USA
    Psychopharmacology (Berl) 191:931-41. 2007
    ..Fentanyl is a potent mu-opioid receptor agonist that is widely used for the treatment of severe chronic pain. Discontinuation of fentanyl administration has been shown to induce a negative emotional state...
  70. pmc NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala
    Paul J Kenny
    Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Neuropsychopharmacology 34:266-81. 2009
    ..Taken together, these data suggest that NMDA receptors, including those in the CeA and VTA, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug...
  71. pmc Tobacco smoke exposure induces nicotine dependence in rats
    Elysia Small
    Department of Psychiatry, College of Medicine, McKnight Brain Institute, University of Florida, 100 S Newell Dr, PO Box 100256, Gainesville, FL 32610, USA
    Psychopharmacology (Berl) 208:143-58. 2010
    ..Therefore, animal models are needed that allow the investigation of chronic exposure to the full spectrum of tobacco smoke constituents...
  72. pmc Somatostatin-28 modulates prepulse inhibition of the acoustic startle response, reward processes and spontaneous locomotor activity in rats
    Svetlana Semenova
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Neuropeptides 44:421-9. 2010
    ....
  73. pmc Preadolescent tobacco smoke exposure leads to acute nicotine dependence but does not affect the rewarding effects of nicotine or nicotine withdrawal in adulthood in rats
    Hidetaka Yamada
    Department of Psychiatry, College of Medicine, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Pharmacol Biochem Behav 95:401-9. 2010
    ....
  74. ncbi Sleep after immobilization stress and sleep deprivation: common features and theoretical integration
    V S Rotenberg
    Abarbanel Mental Health Center, 15 Keren Kayemet Street, Bat Yam, Israel
    Crit Rev Neurobiol 14:225-31. 2000
    ..Sleep deprivation on the rotating platform, like immobilization stress, prevents SA, produces conditions for learned helplessness and, suppresses PS. Such a combination increases PS pressure and decreases body resistance...
  75. ncbi Intracranial self-stimulation to the lateral hypothalamus, a memory improving treatment, results in hippocampal changes in gene expression
    G Huguet
    Universitat de Girona, Departament de Biologia, Facultat de Ciencies, Campus de Montilivi, 17071 Girona, Spain
    Neuroscience 162:359-74. 2009
    ..Our results suggest that ICSS may facilitate learning and memory by regulation of multiple signaling pathways in the hippocampus that may promote neuroplasticity...
  76. pmc The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats
    Xinchun Jin
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0603, USA
    Neuropsychopharmacology 35:2021-36. 2010
    ..The higher selectivity of BINA compared with an mGluR2/3 agonist for drug- vs food-motivated behaviors suggests a therapeutic role for mGluR2 PAMs for the treatment of cocaine addiction and possibly other drugs of abuse...
  77. pmc Mineralocorticoid receptor antagonism prevents hedonic deficits induced by a chronic sodium appetite
    Michael J Morris
    Department of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, The University of Iowa, Iowa City, IA 52242 1407, USA
    Behav Neurosci 124:211-24. 2010
    ..We conclude that an unresolved sodium appetite will reduce responding for rewards and that experimental manipulations that reduce sodium appetite (e.g., access to saline or blockade of MR) decrease hedonic deficits...
  78. ncbi Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Neuropsychopharmacology 32:955-63. 2007
    ..These data provide support for the hypothesis that a hyperactivity of brain CRF systems may at least partly mediate the initiation of the negative affective aspects of nicotine withdrawal...
  79. doi Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus
    Dean S Carson
    Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Addict Biol 15:448-63. 2010
    ..Overall, these results give further insight into the way in which oxytocin might moderate compulsive behaviors and demonstrate the capacity of peripherally administered oxytocin to induce widespread central effects...
  80. ncbi Audiovocal interactions during development? Vocalisation in deafened young horseshoe bats vs. audition in vocalisation-impaired bats
    R Rubsamen
    Zoological Department, University of Kelaniya, Sri Lanka
    J Comp Physiol A 167:771-84. 1990
    ..The significance of this postnatal development might be the adjustment of the vocal motor system of each bat to the frequency of its 'personal' auditory fovea...
  81. ncbi Effects of anxiolytic drugs on rewarding and aversive behaviors induced by intracranial stimulation
    Yutaka Gomita
    Department of Hospital Pharmacy, Okayama Medical School, Okayama 700 8558, Japan
    Acta Med Okayama 57:95-108. 2003
    ....
  82. ncbi Anabolic-androgenic steroids and brain reward
    A S Clark
    Department of Psychology, Dartmouth College, Hanover, NH 03755, USA
    Pharmacol Biochem Behav 53:741-5. 1996
    ..Although AAS do not appear to alter the rewarding properties of brain stimulation, AAS may influence the sensitivity of brain reward systems...
  83. ncbi Cannabinoid transmission and reward-related events
    E L Gardner
    Department of Psychiatry, Albert Einstein College of Medicine, New York, New York 10461 1602, USA
    Neurobiol Dis 5:502-33. 1998
    ..From these actions, presumably, derive both the abuse potential of cannabinoids and the possible clinical efficacy in dysphoric states...
  84. ncbi The role of dopamine in intracranial self-stimulation of the ventral tegmental area
    H C Fibiger
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Neurosci 7:3888-96. 1987
    ..Despite high rates of responding, no effects were observed on DOPAC:DA or HVA:DA ratios in these brain regions.(ABSTRACT TRUNCATED AT 250 WORDS)..
  85. pmc AMPA receptor subunit GluR1 downstream of D-1 dopamine receptor stimulation in nucleus accumbens shell mediates increased drug reward magnitude in food-restricted rats
    K D Carr
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neuroscience 165:1074-86. 2010
    ....
  86. ncbi Lidocaine inactivation of the ventral pallidum affects responding for brain stimulation reward more than it affects the stimulation's reward value
    Meg Waraczynski
    Department of Psychology, University of Wisconsin at Whitewater, 800 West Main Street, Whitewater, WI 53190, USA
    Behav Brain Res 173:288-98. 2006
    ....
  87. ncbi Effects of fentanyl dose and exposure duration on the affective and somatic signs of fentanyl withdrawal in rats
    Jiang Liu
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Neuropharmacology 55:812-8. 2008
    ..These studies suggest that the magnitude and duration of the negative affective signs of fentanyl withdrawal depend on the dose of fentanyl administered and not on the duration of fentanyl administration...
  88. ncbi The medial prefrontal cortex as a part of the brain reward system
    T M Tzschentke
    Department of Pharmacology, Research and Development, Grunenthal GmbH, Aachen, Federal Republic of Germany
    Amino Acids 19:211-9. 2000
    ....
  89. ncbi Study of cannabinoid dependence in animals
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Facultat de Ciences de la Salut I de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Pharmacol Ther 95:153-64. 2002
    ..The mesolimbic dopaminergic system seems to be the substrate for the rewarding properties of cannabinoids...
  90. pmc Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens
    Jennifer A DiNieri
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 29:1855-9. 2009
    ..Together with previous findings, these studies raise the possibility that disruption of CREB in the NAc influences motivation by simultaneously facilitating reward and reducing depressive-like states such as anhedonia and dysphoria...
  91. ncbi Population dynamics of interacting spiking neurons
    Maurizio Mattia
    Physics Laboratory, Istituto Superiore di Sanita, INFN Gr Coll Roma I, V le Regina Elena 299, Italy
    Phys Rev E Stat Nonlin Soft Matter Phys 66:051917. 2002
    ..There is remarkable agreement of the theoretical predictions with simulations of a network of IF neurons with a constant leakage term for the membrane potential...
  92. pmc Incidence of autonomic dysreflexia and silent autonomic dysreflexia in men with spinal cord injury undergoing sperm retrieval: implications for clinical practice
    Marci B Ekland
    International Collaboration on Repair Discoveries, GF Strong Rehab Centre, Sexual Health Rehabilitation Service, Vancouver, British Columbia, Canada
    J Spinal Cord Med 31:33-9. 2008
    ..To determine the incidence of symptomatic autonomic dysreflexia (AD) and asymptomatic autonomic dysreflexia (silent AD) in men with spinal cord injury (SCI) undergoing sperm retrieval procedures...
  93. ncbi Neuroethics of deep brain stimulation for mental disorders: brain stimulation reward in humans
    Hideki Oshima
    Department of Functional Morphology, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Tokyo, Japan
    Neurol Med Chir (Tokyo) 50:845-52. 2010
    ..To develop DBS to the level of a standard therapy for mental disorders, we need to discuss "Who has the right to control the mental condition?" and "Who makes decisions" on "How much control is appropriate?" in daily life...
  94. ncbi Functional MRI of the brain during orgasm in women
    Barry R Komisaruk
    Department of Psychology, Rutgers, The State University of New Jersey, Newark 07102, USA
    Annu Rev Sex Res 16:62-86. 2005
    ..We conclude that the Vagus nerves provide a spinal cord-bypass pathway for vaginal-cervical sensibility and that activation of this pathway can produce analgesia and orgasm...
  95. pmc Brain expression and song regulation of the cholecystokinin gene in the zebra finch (Taeniopygia guttata)
    Peter V Lovell
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    J Comp Neurol 519:211-37. 2011
    ....
  96. doi Intracranial self-stimulation enhances neurogenesis in hippocampus of adult mice and rats
    T Takahashi
    Department of Psychology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu 431 3192, Shizuoka 431 3192, Japan
    Neuroscience 158:402-11. 2009
    ..The results demonstrate that ICSS can increase newborn neurons in the hippocampal DG that endure into maturity...
  97. ncbi Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle
    Yan Lin
    Department of Psychiatry, New York University School of Medicine, New York University Medical Center, New York, NY 10016, USA
    Neuropsychopharmacology 32:835-41. 2007
    ..It is concluded that LC alpha(1)-adrenoceptors are involved both in reward/motivational processes and operant response elaboration which are postulated to work together to facilitate goal attainment...
  98. ncbi Paradoxical modulation of short-term facilitation of dopamine release by dopamine autoreceptors
    Justin M Kita
    Department of Chemistry and Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Neurochem 102:1115-24. 2007
    ..These data demonstrate that the commanding control exerted by dopamine autoreceptors over short-term neuroadaptation of dopamine release involves both inhibitory and paradoxically, facilitatory components...
  99. pmc Synaptic overflow of dopamine in the nucleus accumbens arises from neuronal activity in the ventral tegmental area
    Leslie A Sombers
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    J Neurosci 29:1735-42. 2009
    ..The results from these three distinct experiments directly demonstrate, for the first time, how neuronal firing of dopamine neurons originating in the VTA translates into synaptic overflow in a key terminal region, the NAc shell...
  100. pmc Dopamine type-1 receptor binding in major depressive disorder assessed using positron emission tomography and [11C]NNC-112
    Dara M Cannon
    Department of Psychiatry, Clinical Sciences Institute, National University of Ireland, Galway, Ireland
    Neuropsychopharmacology 34:1277-87. 2009
    ....
  101. ncbi Metabotropic glutamate 2/3 receptor activation induced reward deficits but did not aggravate brain reward deficits associated with spontaneous nicotine withdrawal in rats
    Matthias E Liechti
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Biochem Pharmacol 74:1299-307. 2007
    ..Thus, this mGlu2/3 agonist does not appear to significantly influence the affective depression-like aspects of nicotine withdrawal...

Research Grants77

  1. DYNAMICS OF IN VIVO DOPAMINE RELEASE
    Robert Wightman; Fiscal Year: 2007
    ..Both targets have dynamic concentration fluctuations in regions of the brain that use DA. Their detection will enable a more complete view of the chemical changes associated with reward. ..
  2. Role of noncoding RNAs in schizophrenia
    Claes Wahlestedt; Fiscal Year: 2009
    ..Importantly, the underlying etiology of schizophrenia remains largely unknown and there is a marked need for improved treatment paradigms. The proposed work has the potential to aid in the development of completely novel therapeutics. ..
  3. Modulators of Metabotropic Glutamate Receptor Subtype 2 for Cocaine Dependence
    Nicholas Cosford; Fiscal Year: 2009
    ..The proposed research is a highly innovative, significant and timely multidisciplinary project that draws on the expertise of the research team and addresses the requirements of this RFA. ..
  4. Combined Voltammetry/Electrophysiology in Behaving Rats
    REGINA CARELLI; Fiscal Year: 2009
    ..The information obtained from the present application will provide insight into the neurobiological mechanisms mediating cocaine addiction and thereby aid in the development of pharmacological agents to treat human drug addiction. ..
  5. Adolescent Alcohol,Dysregulated Stress System, and PTSD Vulnerability
    GERHARD SCHULTEIS; Fiscal Year: 2009
    ....
  6. Endocannabinoid Discrimination
    Jenny L Wiley; Fiscal Year: 2010
    ....
  7. DRUGS OF ABUSE, DOPAMINE & CONTROL BY BRAIN PEPTIDES
    BARTLEY HOEBEL; Fiscal Year: 1990
    ....
  8. Combined Voltammetry/Electrophysiology in Behaving Rats
    Regina M Carelli; Fiscal Year: 2010
    ..The information obtained from the present application will provide insight into the neurobiological mechanisms mediating cocaine addiction and thereby aid in the development of pharmacological agents to treat human drug addiction. ..
  9. Role of noncoding RNAs in schizophrenia
    CLAES ROBERT WAHLESTEDT; Fiscal Year: 2011
    ..Importantly, the underlying etiology of schizophrenia remains largely unknown and there is a marked need for improved treatment paradigms. The proposed work has the potential to aid in the development of completely novel therapeutics. ..
  10. Role of noncoding RNAs in schizophrenia
    CLAES ROBERT contact WAHLESTEDT; Fiscal Year: 2010
    ..Importantly, the underlying etiology of schizophrenia remains largely unknown and there is a marked need for improved treatment paradigms. The proposed work has the potential to aid in the development of completely novel therapeutics. ..
  11. Prenatal ethanol exposure effects on reward circuitry and ethanol consumption
    JAMES PATRICK RICE; Fiscal Year: 2012
    ..The results of these experiments will lead to a better understanding of how learning and memory related to alcohol are impacted by early development insults, and provide a therapeutic target for future research and treatments. ..
  12. MARIJUANA & DOPAMINE/ENKEPHALIN BRAIN REWARD SYSTEMS
    ELIOT GARDNER; Fiscal Year: 1990
    ..The health relatedness is clear, given that marijuana is the most widely used illicit drug in the United States, and given the evidence for health consequences of chronic marijuana abuse...
  13. MARIJUANA & DOPAMINE/ENKEPHALIN BRAIN REWARD SYSTEMS
    ELIOT GARDNER; Fiscal Year: 1992
    ..The health relatedness is clear, given that marijuana is the most widely used illicit drug in the United States, and given the evidence for health consequences of chronic marijuana abuse...
  14. CNS OPIOID MECHANISMS THAT MODULATE REWARD AND AVERSION
    KENNETH CARR; Fiscal Year: 1992
    ....
  15. Neurobiology and Treatment of Pain
    SIDNEY S NEGUS; Fiscal Year: 2010
    ....
  16. Neurobiology and Treatment of Pain
    SIDNEY NEGUS; Fiscal Year: 2009
    ....
  17. Role of dopamine signaling in the mood-related effects of salvinorin A
    Elena H Chartoff; Fiscal Year: 2010
    ..The goal of the proposed studies is to determine if salvinorin A modulates brain reward systems by altering dopamine-mediated signaling in the nucleus accumbens, a brain region involved in the regulation of reward. ..
  18. GABAA subtype-specific pharmacological modulation of reward-related behavior
    Uwe Rudolph; Fiscal Year: 2010
    ....
  19. GABAA subtype-specific pharmacological modulation of reward-related behavior
    Uwe Rudolph; Fiscal Year: 2009
    ....
  20. Targeted Library Synthesis and Screening: Allosteric Modulators of Transporters
    Subramaniam Ananthan; Fiscal Year: 2010
    ....
  21. Endogenous cannabinoid control of reward substrates
    Joseph Cheer; Fiscal Year: 2009
    ..Altogether, these experiments should provide an unprecedented insight into accumbal encoding of reward and its physiological modulation by endogenous cannabinoids. ..
  22. Modulators of Metabotropic Glutamate Receptor Subtype 2 for Cocaine Dependence
    Nicholas Cosford; Fiscal Year: 2007
    ..The proposed research is a highly innovative, significant and timely multidisciplinary project that draws on the expertise of the research team and addresses the requirements of this RFA. ..
  23. Effect of prenatal cocaine exposure on brain reward
    C Malanga; Fiscal Year: 2004
    ..abstract_text> ..
  24. Effect of prenatal cocaine exposure on brain reward
    C Malanga; Fiscal Year: 2005
    ..abstract_text> ..
  25. Effect of prenatal cocaine exposure on brain reward
    C Malanga; Fiscal Year: 2003
    ..abstract_text> ..
  26. Optogenetic Manipulation of Brain Reward
    Luis de Lecea; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: This proposal will use state of the art methods to identify neuronal structures involved in brain reward function. ..
  27. Effect of prenatal cocaine exposure on brain reward
    C Malanga; Fiscal Year: 2006
    ..abstract_text> ..
  28. Targeted Library Synthesis and Screening: Allosteric Modulators of Transporters
    Subramaniam Ananthan; Fiscal Year: 2012
    ..These studies should reveal the potential of the allosteric ligands of DAT as treatment agents for substance abuse and psychiatric disorders. ..
  29. NEUROADAPTATIONS IN DRUG SELF-ADMINISTRATION AND RELAPSE
    David Self; Fiscal Year: 2003
    ..abstract_text> ..
  30. Role of CREB in nucleus accumbens in mood and motivation
    Eric Nestler; Fiscal Year: 2002
    ..abstract_text> ..
  31. The alpha5 Nicotinic Acetylcholine Receptor Subunit in Nicotine Dependence
    CHRISTIE FOWLER; Fiscal Year: 2009
    ..Importantly, these findings could lead to the development of novel therapeutics efficacious for smoking cessation and/or relapse prevention in humans. ..
  32. Post-partum steroid withdrawal-induced depression
    REBECCA CRAFT; Fiscal Year: 2005
    ..Findings from the proposed model will enhance our understanding of the etiology of PPD and possibly lead to improved treatment options. ..
  33. "Post-partum steroid withdrawal-induced depression"
    REBECCA CRAFT; Fiscal Year: 2006
    ..Findings from the proposed model will enhance our understanding of the etiology of PPD and possibly lead to improved treatment options. ..
  34. Nicotine dependence and central adiposity signaling
    ADRIAAN WILLEM BRUIJNZEEL; Fiscal Year: 2010
    ..A better understanding of the brain mechanisms underlying post-cessation weight gain may contribute to new treatments for post-cessation weight gain and thereby improve smoking cessation rates. ..
  35. Nicotine dependence and central adiposity signaling
    ADRIAAN BRUIJNZEEL; Fiscal Year: 2009
    ..A better understanding of the brain mechanisms underlying post-cessation weight gain may contribute to new treatments for post-cessation weight gain and thereby improve smoking cessation rates. ..
  36. MATERNAL PROTEIN RESTRICTION AND MENTAL RETARDATION
    OSCAR RESNICK; Fiscal Year: 1980
    ..A study of the effects of malnutrition on behavior will examine learning and memory, motor behavior and self-stimulation activity...
  37. Inflammatory Processes and Depression in a Syngeneic Model of Ovarian Cancer
    DONALD LAMKIN; Fiscal Year: 2009
    ....
  38. NEURAL SUBSTRATE OF COCAINE ABUSE
    ROY WISE; Fiscal Year: 1980
    ..Studies of intravenous stimulant self-administration, intracranial self-stimulation, and drug-self stimulation interactions are planned in the rat; these phenomena will be studied under conditions of pharmacological ..
  39. CELLULAR NEUROBIOLOGY OF ENDORPHINS: ROLE IN DRUG ABUSE
    Steven Henriksen; Fiscal Year: 1990
    ..e. hippocampus and nucleus accumbens) in awake animals involved in a heroin self-administration protocol. Using this paradigm the cellular correlates of opiate reward phenomena will be investigated in a more relevant preparation...
  40. Development of GABABeta Receptor Compounds for Nicotine Dependence
    Athina Markou; Fiscal Year: 2010
    ....
  41. ENDOGENOUS OPIOID PROCESSES: ROLE IN DRUG ABUSE
    Joseph Mayer; Fiscal Year: 1990
    ....
  42. Neurobiology of nicotine reward and dependence in mice
    Athina Markou; Fiscal Year: 2007
    ....
  43. Neurobiology of nicotine reward and dependence in mice
    Athina Markou; Fiscal Year: 2009
    ....
  44. Bupropion and Secondary Motivational Effects of Nicotine
    ANTHONY RAUHUT; Fiscal Year: 2005
    ..S. population to 12% and 16%, accordingly. ..
  45. Neurobiology of nicotine reward and dependence in mice
    Athina Markou; Fiscal Year: 2010
    ....
  46. SUBSTRATES OF BRAIN STIMULATION-INDUCED REWARD
    RONALD CLAVIER; Fiscal Year: 1980
    ..In the case of rejection of the catecholaminergic basis of ICSS, alternative systems have been identified anatomically, and are being analyzed for their functional contributions to this behavior...
  47. Regulation of Drug Addiction by Feeding Related Peptides
    Soledad Cabeza de Vaca; Fiscal Year: 2003
    ..It is expected that the proposed studies will elucidate neuropeptidergic mechanisms that co-regulate energy balance and vulnerability to drug addiction. ..
  48. D2/5HT2 MODULATION OF STIMULANT INDUCED CHANGES IN BSR
    Robert Frank; Fiscal Year: 1992
    ..In addition, these experiments will provide information concerning the potential value of D2 and 5-HT2 antagonists as pharmacotherapies for psychomotor stimulant abuse...
  49. Regulation of Drug Addiction by Feeding Related Peptides
    Soledad Cabeza de Vaca; Fiscal Year: 2004
    ..It is expected that the proposed studies will elucidate neuropeptidergic mechanisms that co-regulate energy balance and vulnerability to drug addiction. ..
  50. Regulation of Drug Addiction by Feeding Related Peptides
    Soledad Cabeza de Vaca; Fiscal Year: 2002
    ..It is expected that the proposed studies will elucidate neuropeptidergic mechanisms that co-regulate energy balance and vulnerability to drug addiction. ..
  51. Regulation of Drug Addiction by Feeding Related Peptides
    Soledad Cabeza de Vaca; Fiscal Year: 2001
    ..It is expected that the proposed studies will elucidate neuropeptidergic mechanisms that co-regulate energy balance and vulnerability to drug addiction. ..
  52. PSYCHOBIOLOGICAL MECHANISMS OF DRUG ABUSE
    Larry Stein; Fiscal Year: 1980
    ..The results are expected to provide a framework for understanding the addictive properties of opiate and stimulant drugs...
  53. SELF-ADMINISTRATION OF BRAIN STIMULATION REWARD
    JAMES STELLAR; Fiscal Year: 1992
    ..Because this is a novel approach a short grant format has been selected. Future grant proposals will focus on the application of psychophysical methods to cocaine self-administration...
  54. Role of dopamine D1 receptors in morphine withdrawal
    Elena Chartoff; Fiscal Year: 2005
    ..This work may lead to new pharmacotherapies that can alleviate aversive and dysphoric states associated with opiate withdrawal and perhaps reduce relapse to drug taking. ..
  55. Role of dopamine D1 receptors in morphine withdrawal
    Elena Chartoff; Fiscal Year: 2006
    ..This work may lead to new pharmacotherapies that can alleviate aversive and dysphoric states associated with opiate withdrawal and perhaps reduce relapse to drug taking. ..
  56. NEUROBIOLOGY OF STIMULANT PSYCHOTOMIMETIC DRUGS
    DWIGHT GERMAN; Fiscal Year: 1980
    ..This tripartite investigation is designed to allow a balanced research effort calculated to allow the most complete interpretation possible of the research results on the roles of DA and NE in mental function and dysfunction...
  57. Efficacy of Novel Triple Uptake Inhibitors in Treating Alcoholism and Depression
    Harry L June; Fiscal Year: 2011
    ..The primary objective of the proposal will be to successfully identify agents that may be used to treat both depression and alcohol addiction in humans. ..
  58. Efficacy of Novel Triple Uptake Inhibitors in Treating Alcoholism and Depression
    HARRY JUNE; Fiscal Year: 2009
    ..The primary objective of the proposal will be to successfully identify agents that may be used to treat both depression and alcohol addiction in humans. ..
  59. Role of Nucleus Accumbens CREB in Depression
    WILLIAM CARLEZON; Fiscal Year: 2001
    ..These studies may establish that elevated CREB expression in the NASh is a "molecular trigger" for depression, and identify novel targets for pharmacotherapies. ..
  60. Role of Nucleus Accumbens CREB in Depression
    WILLIAM CARLEZON; Fiscal Year: 2002
    ..These studies may establish that elevated CREB expression in the NASh is a "molecular trigger" for depression, and identify novel targets for pharmacotherapies. ..
  61. Efficacy of Novel Triple Uptake Inhibitors in Treating Alcoholism and Depression
    Harry L June; Fiscal Year: 2010
    ..The primary objective of the proposal will be to successfully identify agents that may be used to treat both depression and alcohol addiction in humans. ..
  62. Role of Nucleus Accumbens CREB in Depression
    WILLIAM CARLEZON; Fiscal Year: 2004
    ..These studies may establish that elevated CREB expression in the NASh is a "molecular trigger" for depression, and identify novel targets for pharmacotherapies. ..
  63. Role of CRF in the affective symptoms of acute and protracted ethanol withdrawal
    ADRIAAN BRUIJNZEEL; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  64. Role of Nucleus Accumbens CREB in Depression
    WILLIAM CARLEZON; Fiscal Year: 2003
    ..These studies may establish that elevated CREB expression in the NASh is a "molecular trigger" for depression, and identify novel targets for pharmacotherapies. ..
  65. Project 2: Nicotine exposure reduction in rats
    Paul Pentel; Fiscal Year: 2004
    ..In addition, this study parallels and provides complementary information to Dr. Hatsukami's human laboratory studies of smoking reduction...
  66. Role of Nucleus Accumbens CREB in Depression
    WILLIAM CARLEZON; Fiscal Year: 2005
    ..These studies may establish that elevated CREB expression in the NASh is a "molecular trigger" for depression, and identify novel targets for pharmacotherapies. ..
  67. DYNAMICS OF IN VIVO DOPAMINE RELEASE
    Robert Wightman; Fiscal Year: 2009
    ..Both targets have dynamic concentration fluctuations in regions of the brain that use DA. Their detection will enable a more complete view of the chemical changes associated with reward. ..
  68. DRUG MODULATION OF COCAINE-INDUCED CHANGES IN BSR
    Robert Frank; Fiscal Year: 1990
    ..Finally, the influence of imipramine on cocaine's effects will be assessed to determine whether this drug, which has been proposed as a treatment for cocaine dependence, alters cocaine-induced euphoria and/or dysphoria...