self stimulation

Summary

Summary: Stimulation of the brain, which is self-administered. The stimulation may result in negative or positive reinforcement.

Top Publications

  1. ncbi Effects of central leptin infusion on the reward-potentiating effect of D-amphetamine
    Joy Hao
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Brain Res 1087:123-33. 2006
  2. ncbi Real time measurement of stimulated dopamine release in the conscious rat using fast cyclic voltammetry: dopamine release is not observed during intracranial self stimulation
    Z L Kruk
    Department of Pharmacology, Queen Mary and Westfield College, London, UK
    J Neurosci Methods 79:9-19. 1998
  3. ncbi Nicotinic acetylcholine alpha4beta2 receptor regulates the motivational effect of intracranial self stimulation behavior in the runway method
    Hidenori Sagara
    Department of Pharmaceutical Information Sciences, Matsuyama University, Japan
    J Pharmacol Sci 108:455-61. 2008
  4. ncbi Short- and long-term effects of interleukin-2 on weight, food intake, and hedonic mechanisms in the rat
    M Miguelez
    School of Psychology, University of Ottawa, Ottawa, K1N 6N5, Canada
    Behav Brain Res 154:311-9. 2004
  5. ncbi WIN 55,212-2 decreases the reinforcing actions of cocaine through CB1 cannabinoid receptor stimulation
    Styliani Vlachou
    Division of Biopsychology, Laboratory of Neurosciences and Behavior, Department of Psychology, School of Social Sciences, University of Crete, 74100 Rethymnon, Crete, Greece
    Behav Brain Res 141:215-22. 2003
  6. ncbi Two brain sites for cannabinoid reward
    Abraham Zangen
    National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 26:4901-7. 2006
  7. ncbi Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists
    Anton Bespalov
    Institute of Pharmacology, IP Pavlov Medical University, St Petersburg, Russia
    Behav Pharmacol 17:295-302. 2006
  8. ncbi Effects of endocannabinoid neurotransmission modulators on brain stimulation reward
    Styliani Vlachou
    Laboratory of Behavioral Neuroscience, Department of Psychology, School of Social Sciences, University of Crete, 74100 Rethymnon, Crete, Greece
    Psychopharmacology (Berl) 188:293-305. 2006
  9. ncbi The 5-HT3 antagonist Y-25130 blocks cocaine-induced lowering of ICSS reward thresholds in the rat
    Stephen P Kelley
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, Dundee, DD1 9SY Scotland, UK
    Pharmacol Biochem Behav 74:297-302. 2003
  10. ncbi Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for "free chow" and "earned" sucrose intake
    Zul Merali
    Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Canada
    Psychopharmacology (Berl) 165:413-8. 2003

Detail Information

Publications216 found, 100 shown here

  1. ncbi Effects of central leptin infusion on the reward-potentiating effect of D-amphetamine
    Joy Hao
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Brain Res 1087:123-33. 2006
    ..Together, results of this study support the importance of weight loss, but not leptin, in the enhancement of drug reward sensitivity...
  2. ncbi Real time measurement of stimulated dopamine release in the conscious rat using fast cyclic voltammetry: dopamine release is not observed during intracranial self stimulation
    Z L Kruk
    Department of Pharmacology, Queen Mary and Westfield College, London, UK
    J Neurosci Methods 79:9-19. 1998
    ..Rats trained on a continuous reinforcement schedule to perform intracranial self stimulation (ICSS) were implanted with electrodes for FCV...
  3. ncbi Nicotinic acetylcholine alpha4beta2 receptor regulates the motivational effect of intracranial self stimulation behavior in the runway method
    Hidenori Sagara
    Department of Pharmaceutical Information Sciences, Matsuyama University, Japan
    J Pharmacol Sci 108:455-61. 2008
    ..These results demonstrate that nicotine enhances the running speed towards the goal lever via alpha4beta2 nicotinic receptors and suggest that alpha4beta2 nicotinic receptors influence the brain mechanism of motivation...
  4. ncbi Short- and long-term effects of interleukin-2 on weight, food intake, and hedonic mechanisms in the rat
    M Miguelez
    School of Psychology, University of Ottawa, Ottawa, K1N 6N5, Canada
    Behav Brain Res 154:311-9. 2004
    ..We further suggest that since this modulation appears to be notably site-specific, IL-2 receptors or its metabolites may not be evenly distributed within the medial forebrain bundle...
  5. ncbi WIN 55,212-2 decreases the reinforcing actions of cocaine through CB1 cannabinoid receptor stimulation
    Styliani Vlachou
    Division of Biopsychology, Laboratory of Neurosciences and Behavior, Department of Psychology, School of Social Sciences, University of Crete, 74100 Rethymnon, Crete, Greece
    Behav Brain Res 141:215-22. 2003
    ....
  6. ncbi Two brain sites for cannabinoid reward
    Abraham Zangen
    National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 26:4901-7. 2006
    ..These findings link the sites of rewarding action of Delta9THC to brain regions where such drugs as amphetamines, cocaine, heroin, and nicotine are also thought to have their sites of rewarding action...
  7. ncbi Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists
    Anton Bespalov
    Institute of Pharmacology, IP Pavlov Medical University, St Petersburg, Russia
    Behav Pharmacol 17:295-302. 2006
    ..These results indicate that, within a limited dose range, caffeine in combination with an NMDA receptor channel blocker and a competitive antagonist significantly lowers brain stimulation reward thresholds in rats...
  8. ncbi Effects of endocannabinoid neurotransmission modulators on brain stimulation reward
    Styliani Vlachou
    Laboratory of Behavioral Neuroscience, Department of Psychology, School of Social Sciences, University of Crete, 74100 Rethymnon, Crete, Greece
    Psychopharmacology (Berl) 188:293-305. 2006
    ..However, the relevant studies concerning the ability of endocannabinoid modulators to modify reward processes in experimental animals remain rather scarce...
  9. ncbi The 5-HT3 antagonist Y-25130 blocks cocaine-induced lowering of ICSS reward thresholds in the rat
    Stephen P Kelley
    Department of Pharmacology and Neuroscience, Ninewells Hospital and Medical School, Dundee, DD1 9SY Scotland, UK
    Pharmacol Biochem Behav 74:297-302. 2003
    ..3 and 3.0 mg/kg) did attenuate the threshold-lowering effect of cocaine. These findings suggest that the rewarding effects of cocaine are mediated through 5-HT(3) receptor activity...
  10. ncbi Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for "free chow" and "earned" sucrose intake
    Zul Merali
    Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Canada
    Psychopharmacology (Berl) 165:413-8. 2003
    ..Analysis of the behavioral effects of interleukin-1beta (IL-1beta), and their modification by antidepressants, is complicated since the anorexic and anhedonic effects of the cytokine are not readily dissociated from one another...
  11. ncbi Increase in accumbal dopaminergic transmission correlates with response cost not reward of hypothalamic stimulation
    Darryl B Neill
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Behav Brain Res 137:129-38. 2002
    ....
  12. ncbi Exposure to chronic mild stress alters thresholds for lateral hypothalamic stimulation reward and subsequent responsiveness to amphetamine
    D Lin
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torry Pines Road, La Jolla, CA 92037, USA
    Neuroscience 114:925-33. 2002
    ..These findings support the hypothesis that prior exposure to stress affects the vulnerability for drug-taking behavior by increasing the positive reinforcing properties of drug of abuse...
  13. ncbi Does neuropeptide Y contribute to the modulation of brain stimulation reward by chronic food restriction?
    Stephanie Fulton
    Center for Studies in Behavioural Neurobiology, Concordia University, Hall Building Rm 1013, 1455 de Maisonneuve Blvd, Montreal QC, Canada H3G 1M8
    Behav Brain Res 134:157-64. 2002
    ..These findings suggest that NPY does not take part in the process whereby food restriction and leptin modulate reward circuitry activated by stimulating restriction-sensitive sites...
  14. ncbi [Effects of antidepressants in models of brain self-stimulation and place preference after prolong social isolation and alcoholization]
    P D Shabanov
    Eksp Klin Farmakol 69:60-5. 2006
    ..It is concluded that antidepressants studied activate the reinforcing properties of the brain, that is associated with the involvement of both the catecholamine and serotonin system, working reciprocally...
  15. ncbi Contrasting effects of dopamine antagonists and frequency reduction on Fos expression induced by lateral hypothalamic stimulation
    Glenn E Hunt
    Department of Psychological Medicine, University of Sydney, Concord Hospital, Concord, NSW 2139, Australia
    Behav Brain Res 132:187-201. 2002
    ..These results reveal the utility of Fos immunohistochemistry to show how different treatments that alter the rewarding impact of electrical brain stimulation achieve their effects at the neural level...
  16. ncbi Investigating the hedonic effects of interferon-alpha on female rats using brain-stimulation reward
    Amanda C Kentner
    School of Psychology, University of Ottawa, Ottawa, Canada K1N 6N5
    Behav Brain Res 177:90-9. 2007
    ..This pattern was also evident in the overall total sickness behaviour scores. Our data suggest that a single exposure to IFN-alpha treatment in female rats elicits long-term somatic effects, without altering hedonic status...
  17. ncbi Facilitation of electrical brain self-stimulation behavior by abused solvents
    Anton Bespalov
    Department of Psychopharmacology, Institute of Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg 197089, Russia
    Pharmacol Biochem Behav 75:199-208. 2003
    ..Data from intracranial self-stimulation studies of solvents may be useful in abuse potential assessment of individual compounds and for examining neural and behavioral processes involved in inhalant abuse...
  18. ncbi Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction
    Laura E O'Dell
    Molecular and Integrative Neuroscience Department, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 186:612-9. 2006
    ..Enhanced reinforcing effects of nicotine during adolescence appear to contribute to the rapid development of dependence in this age group. However, the contribution of nicotine withdrawal to dependence in adolescents is unclear...
  19. ncbi Roles of pedunculopontine tegmental cholinergic receptors in brain stimulation reward in the rat
    J Chen
    Department of Psychology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192, Japan
    Psychopharmacology (Berl) 184:514-22. 2006
    ..However, to date there is little direct evidence to support this hypothesis...
  20. ncbi Mesencephalic substrate of reward: lesion effects
    Sandra M Boye
    Centre de Recherche Fernand Seguin, Hopital Louis H Lafontaine, 7331 Hochelaga, Montreal, Que, Canada H1N 3V2
    Behav Brain Res 156:31-43. 2005
    ....
  21. ncbi The basolateral complex of the amygdala mediates the modulation of intracranial self-stimulation threshold by drug-associated cues
    Robert J Hayes
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Dr, Baltimore, Maryland 21224, USA
    Eur J Neurosci 20:273-80. 2004
    ..We conclude that the BLC is necessary for cues associated with previous drug exposure to modulate activity within or downstream from the classical reward circuitry of the medial forebrain bundle...
  22. ncbi Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats
    Paul J Kenny
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 179:247-54. 2005
    ..Evidence is accumulating that metabotropic glutamate 5 (mGlu5) receptors play an important role in regulating the reinforcing actions of drugs of abuse...
  23. ncbi Mapping the neural substrate underlying brain stimulation reward with the behavioral adaptation of double-pulse methods
    Maia Miguelez
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
    Rev Neurosci 15:47-74. 2004
    ..Attention is drawn to the major contribution of these methods to our understanding of the neural pathways and characteristics underlying BSR...
  24. ncbi A progressive ratio schedule of self-stimulation testing in rats reveals profound augmentation of d-amphetamine reward by food restriction but no effect of a "sensitizing" regimen of d-amphetamine
    Soledad Cabeza de Vaca
    Department of Psychiatry Millhauser Laboratories, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 175:106-13. 2004
    ....
  25. ncbi A new rat model of the human serial reaction time task: contrasting effects of caudate and hippocampal lesions
    Michael A Christie
    Center for Aging Genetics and Neurodegeneration, Department of Neurology, Massachusetts General Hospital and Harvard School of Medicine, Boston, Massachusetts 02129, USA
    J Neurosci 24:1034-9. 2004
    ..By contrast, rats with dorsal hippocampal lesions showed an interference effect at all sequence lengths. This new rat SRT model clarifies the basal ganglia-limbic system dichotomy suggested by human work...
  26. ncbi The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat
    David A Slattery
    Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Neuropsychopharmacology 30:2065-72. 2005
    ..Therefore, GABAB-positive modulation may represent a novel therapeutic strategy for the treatment of cocaine dependence and possibly other drugs of abuse without the side effects of full GABAB receptor agonists...
  27. ncbi Slower extinction of responses maintained by intra-cranial self-stimulation (ICSS) in an animal model of attention-deficit/hyperactivity disorder (ADHD)
    Espen Borgå Johansen
    Department of Physiology, University of Oslo, Norway Centre for Advanced Study, P O Box 1103 Blindern, 0317 Oslo, Norway
    Behav Brain Res 162:22-31. 2005
    ..Slower extinction of previously reinforced behavior is suggested as an alternative explanation for the frequently observed increased behavioral output that has previously been interpreted as "disinhibition" of behavior in ADHD...
  28. ncbi Neural correlates to action and rewards in the rat posterior cingulate cortex
    Eiichi Tabuchi
    System Emotional Science, Graduate School of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930 0194, Japan
    Neuroreport 16:949-53. 2005
    ..The present results and comparison with previous studies on the anterior cingulate cortex suggest that the posterior cingulate cortex is involved in the monitoring or storage of action-reward outcome association...
  29. ncbi Prolonged nicotine exposure does not alter GABA(B) receptor-mediated regulation of brain reward function
    Neil E Paterson
    Department of Molecular and Integrative Neuroscience, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 49:953-62. 2005
    ....
  30. ncbi Facilitation of brain stimulation reward by MK-801 (dizocilpine) may be independent of D2-like dopamine receptor stimulation in rats
    R L H Clements
    Department of Psychiatry, and Centre for Neuroscience, University of Alberta, Edmonton, Alberta, T6G 2B7, Canada
    Psychopharmacology (Berl) 182:65-74. 2005
    ..We have recently demonstrated synergistic effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor blockade and D(2/3) DA receptor stimulation in brain stimulation reward (BSR)...
  31. ncbi Exposure of mice to a predator odor increases acoustic startle but does not disrupt the rewarding properties of VTA intracranial self-stimulation
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Brain Res 982:195-210. 2003
    ..Moreover, the anxiogenic properties of psychogenic stressors can be separated from their anhedonic effects. The implications of these data for clinical psychopathology are discussed...
  32. ncbi Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice
    G I Elmer
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Maple and Locust Streets, Baltimore, MD 21228, USA
    Psychopharmacology (Berl) 182:33-44. 2005
    ..Genetically engineered animal models provide a complementary approach to pharmacological investigations...
  33. ncbi The effects of ventral tegmental administration of GABA(A), GABA(B), NMDA and AMPA receptor agonists on ventral pallidum self-stimulation
    George Panagis
    University of Crete, School of Social Sciences, Department of Psychology, Crete, Rethymnon, Greece
    Behav Brain Res 131:115-23. 2002
    ..The decreased rewarding efficacy of VP self-stimulation following intrategmental injections of muscimol and baclofen may be due to GABAergic modulation of ventral tegmental dopaminergic and nondopaminergic neurons projecting to the VP...
  34. ncbi Medial forebrain bundle stimulation evokes endocannabinoid-mediated modulation of ventral tegmental area dopamine neuron firing in vivo
    Giuliano Pillolla
    B B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, 09042, Monserrato, Cagliari, Italy
    Psychopharmacology (Berl) 191:843-53. 2007
    ..However, their functional and/or behavioural correlates are yet to be determined...
  35. ncbi Histochemical mapping of the substrate for brain-stimulation reward with glycogen phosphorylase
    A T Konkle
    School of Psychology, University of Ottawa, Ont, Canada
    J Neurosci Methods 93:111-9. 1999
    ....
  36. ncbi Motivational effects of nicotine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior
    Hidenori Sagara
    Department of Pharmacy, Okayama University Hospital, Okayama, Japan
    Acta Med Okayama 62:227-33. 2008
    ..The runway method using priming stimulation of ICSS behavior may become the new experimental methodology with which to measure the motivational effect of some drugs...
  37. pmc Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats
    Daria Rylkova
    Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
    Neuropeptides 42:215-27. 2008
    ..In addition, NPY decreases the sensitivity to rewarding electrical stimuli via an Y1 dependent mechanism...
  38. ncbi Motivational effects of methamphetamine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior
    Hidenori Sagara
    Department of Hospital Pharmacy, Okayama University Medical School, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Biol Pharm Bull 31:541-5. 2008
    ..These results suggest that the runway method using priming stimulation of ICSS behavior may be an effective way to evaluate the enhancing effect of a drug on motivation...
  39. ncbi Dopamine tone increases similarly during predictable and unpredictable administration of rewarding brain stimulation at short inter-train intervals
    Giovanni Hernandez
    Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec H4B 1R6, Canada
    Behav Brain Res 188:227-32. 2008
    ..This finding is consistent with the idea that tonic DA signaling is insensitive to the predictability of rewards...
  40. ncbi Factors that influence the persistence of stimulation-induced aversion
    M Diotte
    School of Psychology, University of Ottawa, 145 Jean-Jacques Lussier Street, P.O. Box 450, Station A, K1N 6N5, Ottawa, Ontario, Canada
    Physiol Behav 72:661-7. 2001
    ..One interpretation of these findings is that the aversion mechanisms associated with the Gi and DTg are differentially susceptible to analgesic processes...
  41. ncbi Self-stimulation rewarding experience restores stress-induced CA3 dendritic atrophy, spatial memory deficits and alterations in the levels of neurotransmitters in the hippocampus
    K Ramkumar
    Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Hosur Road, PB 2900, Bangalore, 560 029, Karnataka, India
    Neurochem Res 33:1651-62. 2008
    ..We propose that SS rewarding behavioral experience ameliorates the stress-induced cognitive deficits by inducing structural and biochemical changes in the hippocampus...
  42. ncbi Consistent rewarding or aversive effects of the electrical stimulation of the lateral parabrachial complex
    Maria J Simon
    Psychobiology, University of Granada, Campus de Cartuja s n, Granada, Spain
    Behav Brain Res 190:67-73. 2008
    ..Therefore, the activation of aversive or rewarding systems may depend on the precise location of the electrode implanted in the LPBe of each animal...
  43. ncbi Withdrawal from chronic amphetamine induces depressive-like behavioral effects in rodents
    John F Cryan
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:49-58. 2003
    ....
  44. ncbi Ameliorative effects of a cognitive enhancer, T-588, on place learning deficits induced by transient forebrain ischemia in rats
    Y Nakada
    Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan
    Physiol Behav 74:227-35. 2001
    ..These results suggested that T-588 has ameliorative effects on learning deficits induced by brain ischemia, which could be produced through enhancement of residual cognitive functions...
  45. ncbi Measuring threshold shifts for brain stimulation reward using the method of limits
    A T Konkle
    University of Ottawa
    Can J Exp Psychol 55:253-60. 2001
    ..Our findings suggest that the threshold procedure is generally not influenced by the sequence of delivery of stimulus values and, thus, may be regarded as a reliable measure of the reinforcing properties of brain-stimulation reward...
  46. pmc Brain stimulation reward is integrated by a network of electrically coupled GABA neurons
    Matthew B Lassen
    Brigham Young University, Provo, UT 84602, USA
    Brain Res 1156:46-58. 2007
    ..Thus, a network of electrically coupled GABA neurons in the ventral brain may form the elusive neural integrator of BSR...
  47. ncbi Predictable and unpredictable rewards produce similar changes in dopamine tone
    Giovanni Hernandez
    Center for Studies in Behavioural Neurobiology, Concordia University, Montreal, PQ, Canada
    Behav Neurosci 121:887-95. 2007
    ..Nonetheless, indistinguishable changes in DA concentration were observed in the 2 groups. Thus, reward predictability had no discernable effect on a measure believed to track the slower components of DA signaling...
  48. ncbi In rats, acute morphine dependence results in antagonist-induced response suppression of intracranial self-stimulation
    Keith W Easterling
    Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA, USA
    Psychopharmacology (Berl) 175:287-95. 2004
    ..Lower (0.001-1.0 mg/kg) doses of the opioid antagonist naltrexone produce few behavioral effects in otherwise drug-free rats responding for ICSS, but reduce response rates by up to 75% after a single dose of morphine...
  49. ncbi Accidental death due to complete autoerotic asphyxia associated with transvestic fetishism and anal self-stimulation - case report
    Tatjana Atanasijevic
    Institute of Forensic Medicine, School of Medicine, Belgrade, Serbia
    Psychiatr Danub 21:246-51. 2009
    ....
  50. ncbi Opposite effects of ibotenic acid and 6-hydroxydopamine lesions of the lateral hypothalamus on intracranial self-stimulation and stimulation-induced locomotion
    L Velley
    CNRS UA 339, Talence, France
    Neuroscience 25:595-603. 1988
    ..Furthermore, the brains of two rats unilaterally injected with the usual dose of 6-hydroxydopamine were processed for tyrosine hydroxylase immunocytochemistry.(ABSTRACT TRUNCATED AT 250 WORDS)..
  51. ncbi Blood pressure changes during sexual stimulation, ejaculation and midodrine treatment in men with spinal cord injury
    Frédérique J Courtois
    Department of Sexology, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    BJU Int 101:331-7. 2008
    ....
  52. ncbi Effects of the D(3) dopamine receptor antagonist, U99194A, on brain stimulation and d-amphetamine reward, motor activity, and c-fos expression in ad libitum fed and food-restricted rats
    K D Carr
    Department of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Psychopharmacology (Berl) 163:76-84. 2002
    ..However, the locations of the D(3) receptors that regulate behavior, and the range of behavioral functions regulated, are not clear...
  53. ncbi Role of dopamine in the behavioural actions of nicotine related to addiction
    G Di Chiara
    Department of Toxicology and CNR Center of Neuropharmacology, University of Cagliari, Viale Diaz 182, 09100 Cagliari, Italy
    Eur J Pharmacol 393:295-314. 2000
    ..Unavailability of tobacco disrupts the automatic, implicit modality of abnormal habit responding switching responding into the explicit, conscious modality of incentive drug-seeking and craving...
  54. ncbi Chronic bupropion differentially alters the reinforcing, reward-enhancing and conditioned motivational properties of nicotine in rats
    Neil E Paterson
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Nicotine Tob Res 10:995-1008. 2008
    ..Rather, preclinical investigations suggest that bupropion attenuates nicotine-induced enhancement of brain reward function and reverses the anhedonic, somatic, and neurochemical correlates of nicotine withdrawal...
  55. ncbi Alcohol, cocaine, and brain stimulation-reward in C57Bl6/J and DBA2/J mice
    Eric W Fish
    Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Alcohol Clin Exp Res 34:81-9. 2010
    ..These experiments had 2 objectives: first, to establish the effects of alcohol on ICSS responding in the C57Bl6/J (C57) and DBA2/J (DBA) mouse strains; and second, to compare these effects to those of the psychostimulant cocaine...
  56. pmc Attention deficits and hyperactivity following inhibition of cAMP-dependent protein kinase within the medial prefrontal cortex of rats
    Tracie A Paine
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 34:2143-55. 2009
    ..These studies indicate that PKA inhibition within the mPFC of rats produces inattention and hyperactivity, and thus might be useful in modeling human attention disorders...
  57. pmc Dopamine signals for reward value and risk: basic and recent data
    Wolfram Schultz
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
    Behav Brain Funct 6:24. 2010
    ..This review provides an updated overview about the basic signals of dopamine neurons to environmental stimuli...
  58. ncbi Excitability and gap junction-mediated mechanisms in nucleus accumbens regulate self-stimulation reward in rats
    L Kokarovtseva
    Neuroscience and Mental Health Programme and Brain and Behaviour Centre, Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada M5G1X8
    Neuroscience 159:1257-63. 2009
    ..Thus, the Acb provides a site for the study of pleasure/reward, addiction and conscious experience...
  59. ncbi Route of administration affects the ability of naltrexone to reduce amphetamine-potentiated brain stimulation reward in rats
    Mark S Todtenkopf
    Department of Life Sciences and Toxicology, Alkermes, Inc, USA
    Addict Biol 14:408-18. 2009
    ..In summary, an extended-release formulation of naltrexone results in significant attenuation of psychostimulant-enhanced BSR that is not observed with acute naltrexone...
  60. ncbi Locomotion induced by non-contingent intracranial stimulation: comparison to psychomotor stimulant
    Valeri Farmer-Dougan
    Departments of Psychology and Biological Sciences, Illinois State University, Normal, IL 61790 4620, USA
    Behav Processes 67:245-61. 2004
    ..The results suggest that locomotion elicited by nEAS was stereotypic, dependent upon DA release and similar, but not identical, to psychomotor stimulant-induced locomotion...
  61. ncbi The effects of buprenorphine on fentanyl withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, 100 S Newell Dr, 100256, Gainesville, FL 32610 0244, USA
    Psychopharmacology (Berl) 191:931-41. 2007
    ..Fentanyl is a potent mu-opioid receptor agonist that is widely used for the treatment of severe chronic pain. Discontinuation of fentanyl administration has been shown to induce a negative emotional state...
  62. pmc NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala
    Paul J Kenny
    Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Neuropsychopharmacology 34:266-81. 2009
    ..Taken together, these data suggest that NMDA receptors, including those in the CeA and VTA, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug...
  63. pmc Somatostatin-28 modulates prepulse inhibition of the acoustic startle response, reward processes and spontaneous locomotor activity in rats
    Svetlana Semenova
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Neuropeptides 44:421-9. 2010
    ....
  64. pmc Tobacco smoke exposure induces nicotine dependence in rats
    Elysia Small
    Department of Psychiatry, College of Medicine, McKnight Brain Institute, University of Florida, 100 S Newell Dr, PO Box 100256, Gainesville, FL 32610, USA
    Psychopharmacology (Berl) 208:143-58. 2010
    ..Therefore, animal models are needed that allow the investigation of chronic exposure to the full spectrum of tobacco smoke constituents...
  65. ncbi Intracranial self-stimulation to the lateral hypothalamus, a memory improving treatment, results in hippocampal changes in gene expression
    G Huguet
    Universitat de Girona, Departament de Biologia, Facultat de Ciencies, Campus de Montilivi, 17071 Girona, Spain
    Neuroscience 162:359-74. 2009
    ..Our results suggest that ICSS may facilitate learning and memory by regulation of multiple signaling pathways in the hippocampus that may promote neuroplasticity...
  66. ncbi Sleep after immobilization stress and sleep deprivation: common features and theoretical integration
    V S Rotenberg
    Abarbanel Mental Health Center, 15 Keren Kayemet Street, Bat Yam, Israel
    Crit Rev Neurobiol 14:225-31. 2000
    ..Sleep deprivation on the rotating platform, like immobilization stress, prevents SA, produces conditions for learned helplessness and, suppresses PS. Such a combination increases PS pressure and decreases body resistance...
  67. pmc The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats
    Xinchun Jin
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0603, USA
    Neuropsychopharmacology 35:2021-36. 2010
    ..The higher selectivity of BINA compared with an mGluR2/3 agonist for drug- vs food-motivated behaviors suggests a therapeutic role for mGluR2 PAMs for the treatment of cocaine addiction and possibly other drugs of abuse...
  68. pmc Mineralocorticoid receptor antagonism prevents hedonic deficits induced by a chronic sodium appetite
    Michael J Morris
    Department of Psychology, Integrative Physiology and Pharmacology, and the Cardiovascular Center, The University of Iowa, Iowa City, IA 52242 1407, USA
    Behav Neurosci 124:211-24. 2010
    ..We conclude that an unresolved sodium appetite will reduce responding for rewards and that experimental manipulations that reduce sodium appetite (e.g., access to saline or blockade of MR) decrease hedonic deficits...
  69. ncbi Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus
    Dean S Carson
    Brain and Mind Research Institute, University of Sydney, NSW, Australia
    Addict Biol 15:448-63. 2010
    ..Overall, these results give further insight into the way in which oxytocin might moderate compulsive behaviors and demonstrate the capacity of peripherally administered oxytocin to induce widespread central effects...
  70. ncbi Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats
    Adrie W Bruijnzeel
    Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Neuropsychopharmacology 32:955-63. 2007
    ..These data provide support for the hypothesis that a hyperactivity of brain CRF systems may at least partly mediate the initiation of the negative affective aspects of nicotine withdrawal...
  71. ncbi Audiovocal interactions during development? Vocalisation in deafened young horseshoe bats vs. audition in vocalisation-impaired bats
    R Rubsamen
    Zoological Department, University of Kelaniya, Sri Lanka
    J Comp Physiol A 167:771-84. 1990
    ..The significance of this postnatal development might be the adjustment of the vocal motor system of each bat to the frequency of its 'personal' auditory fovea...
  72. ncbi Cannabinoid transmission and reward-related events
    E L Gardner
    Department of Psychiatry, Albert Einstein College of Medicine, New York, New York 10461 1602, USA
    Neurobiol Dis 5:502-33. 1998
    ..From these actions, presumably, derive both the abuse potential of cannabinoids and the possible clinical efficacy in dysphoric states...
  73. ncbi The role of dopamine in intracranial self-stimulation of the ventral tegmental area
    H C Fibiger
    Department of Psychiatry, University of British Columbia, Vancouver, Canada
    J Neurosci 7:3888-96. 1987
    ..Despite high rates of responding, no effects were observed on DOPAC:DA or HVA:DA ratios in these brain regions.(ABSTRACT TRUNCATED AT 250 WORDS)..
  74. ncbi Effects of anxiolytic drugs on rewarding and aversive behaviors induced by intracranial stimulation
    Yutaka Gomita
    Department of Hospital Pharmacy, Okayama Medical School, Okayama 700 8558, Japan
    Acta Med Okayama 57:95-108. 2003
    ....
  75. pmc AMPA receptor subunit GluR1 downstream of D-1 dopamine receptor stimulation in nucleus accumbens shell mediates increased drug reward magnitude in food-restricted rats
    K D Carr
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neuroscience 165:1074-86. 2010
    ....
  76. ncbi Effects of fentanyl dose and exposure duration on the affective and somatic signs of fentanyl withdrawal in rats
    Jiang Liu
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Neuropharmacology 55:812-8. 2008
    ..These studies suggest that the magnitude and duration of the negative affective signs of fentanyl withdrawal depend on the dose of fentanyl administered and not on the duration of fentanyl administration...
  77. ncbi Lidocaine inactivation of the ventral pallidum affects responding for brain stimulation reward more than it affects the stimulation's reward value
    Meg Waraczynski
    Department of Psychology, University of Wisconsin at Whitewater, 800 West Main Street, Whitewater, WI 53190, USA
    Behav Brain Res 173:288-98. 2006
    ....
  78. pmc Incidence of autonomic dysreflexia and silent autonomic dysreflexia in men with spinal cord injury undergoing sperm retrieval: implications for clinical practice
    Marci B Ekland
    International Collaboration on Repair Discoveries, GF Strong Rehab Centre, Sexual Health Rehabilitation Service, Vancouver, British Columbia, Canada
    J Spinal Cord Med 31:33-9. 2008
    ..To determine the incidence of symptomatic autonomic dysreflexia (AD) and asymptomatic autonomic dysreflexia (silent AD) in men with spinal cord injury (SCI) undergoing sperm retrieval procedures...
  79. pmc Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens
    Jennifer A DiNieri
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 29:1855-9. 2009
    ..Together with previous findings, these studies raise the possibility that disruption of CREB in the NAc influences motivation by simultaneously facilitating reward and reducing depressive-like states such as anhedonia and dysphoria...
  80. ncbi The medial prefrontal cortex as a part of the brain reward system
    T M Tzschentke
    Department of Pharmacology, Research and Development, Grunenthal GmbH, Aachen, Federal Republic of Germany
    Amino Acids 19:211-9. 2000
    ....
  81. ncbi Functional MRI of the brain during orgasm in women
    Barry R Komisaruk
    Department of Psychology, Rutgers, The State University of New Jersey, Newark 07102, USA
    Annu Rev Sex Res 16:62-86. 2005
    ..We conclude that the Vagus nerves provide a spinal cord-bypass pathway for vaginal-cervical sensibility and that activation of this pathway can produce analgesia and orgasm...
  82. ncbi Study of cannabinoid dependence in animals
    Rafael Maldonado
    Laboratori de Neurofarmacologia, Facultat de Ciences de la Salut I de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Pharmacol Ther 95:153-64. 2002
    ..The mesolimbic dopaminergic system seems to be the substrate for the rewarding properties of cannabinoids...
  83. ncbi Population dynamics of interacting spiking neurons
    Maurizio Mattia
    Physics Laboratory, Istituto Superiore di Sanita, INFN Gr Coll Roma I, V le Regina Elena 299, Italy
    Phys Rev E Stat Nonlin Soft Matter Phys 66:051917. 2002
    ..There is remarkable agreement of the theoretical predictions with simulations of a network of IF neurons with a constant leakage term for the membrane potential...
  84. pmc Brain expression and song regulation of the cholecystokinin gene in the zebra finch (Taeniopygia guttata)
    Peter V Lovell
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    J Comp Neurol 519:211-37. 2011
    ....
  85. ncbi Neuroethics of deep brain stimulation for mental disorders: brain stimulation reward in humans
    Hideki Oshima
    Department of Functional Morphology, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Tokyo, Japan
    Neurol Med Chir (Tokyo) 50:845-52. 2010
    ..To develop DBS to the level of a standard therapy for mental disorders, we need to discuss "Who has the right to control the mental condition?" and "Who makes decisions" on "How much control is appropriate?" in daily life...
  86. ncbi Paradoxical modulation of short-term facilitation of dopamine release by dopamine autoreceptors
    Justin M Kita
    Department of Chemistry and Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Neurochem 102:1115-24. 2007
    ..These data demonstrate that the commanding control exerted by dopamine autoreceptors over short-term neuroadaptation of dopamine release involves both inhibitory and paradoxically, facilitatory components...
  87. ncbi Role of alpha(1)-adrenoceptors of the locus coeruleus in self-stimulation of the medial forebrain bundle
    Yan Lin
    Department of Psychiatry, New York University School of Medicine, New York University Medical Center, New York, NY 10016, USA
    Neuropsychopharmacology 32:835-41. 2007
    ..It is concluded that LC alpha(1)-adrenoceptors are involved both in reward/motivational processes and operant response elaboration which are postulated to work together to facilitate goal attainment...
  88. ncbi Intracranial self-stimulation enhances neurogenesis in hippocampus of adult mice and rats
    T Takahashi
    Department of Psychology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu 431 3192, Shizuoka 431 3192, Japan
    Neuroscience 158:402-11. 2009
    ..The results demonstrate that ICSS can increase newborn neurons in the hippocampal DG that endure into maturity...
  89. ncbi Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sjögren's syndrome
    Capucine Daridon
    Laboratory of Immunology, Brest University Medical School Hospital, Brest, France
    Arthritis Rheum 56:1134-44. 2007
    ..To identify the cells that produce BAFF in the salivary glands of patients with primary Sjögren's syndrome (SS), and to analyze BAFF receptor expression by local T and B lymphocytes...
  90. ncbi [Effect of the melanostatin analogue alaptide on dopamine-dependent behavior in rats reared in isolation]
    A A Lebedev
    Institute for Experimental Medicine, Russian Academy of Medical Sciences, St Petersburg
    Zh Vyssh Nerv Deiat Im I P Pavlova 50:716-9. 2000
    ..At the same time, alaptide suppressed the effects of amphetamine on self-stimulation of rats reared in isolation. The central dopamine mechanisms of melanostatine action are discussed...
  91. pmc Dopamine type-1 receptor binding in major depressive disorder assessed using positron emission tomography and [11C]NNC-112
    Dara M Cannon
    Department of Psychiatry, Clinical Sciences Institute, National University of Ireland, Galway, Ireland
    Neuropsychopharmacology 34:1277-87. 2009
    ....
  92. pmc Synaptic overflow of dopamine in the nucleus accumbens arises from neuronal activity in the ventral tegmental area
    Leslie A Sombers
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, USA
    J Neurosci 29:1735-42. 2009
    ..The results from these three distinct experiments directly demonstrate, for the first time, how neuronal firing of dopamine neurons originating in the VTA translates into synaptic overflow in a key terminal region, the NAc shell...
  93. ncbi Metabotropic glutamate 2/3 receptor activation induced reward deficits but did not aggravate brain reward deficits associated with spontaneous nicotine withdrawal in rats
    Matthias E Liechti
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Biochem Pharmacol 74:1299-307. 2007
    ..Thus, this mGlu2/3 agonist does not appear to significantly influence the affective depression-like aspects of nicotine withdrawal...
  94. ncbi Effects of delta9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress
    S Fokos
    Laboratory of Behavioral Neuroscience, Department of Psychology, School of Social Sciences, University of Crete, Crete, Greece
    J Psychopharmacol 24:767-77. 2010
    ....
  95. ncbi Healthy brain aging: role of cognitive reserve, cognitive stimulation, and cognitive exercises
    Asenath La Rue
    Wisconsin Alzheimer s Institute, School of Medicine and Public Health, University of Wisconsin Madison, 7818 Big Sky Drive, Suite 215, Madison, WI 53719, USA
    Clin Geriatr Med 26:99-111. 2010
    ..More randomized controlled trials, using challenging regimes of training and stimulation and long-term follow-up, are needed, measuring cognitive trajectories in normal aging and relative risk of Alzheimer disease as outcomes...
  96. pmc Dissociable effects of the noncompetitive NMDA receptor antagonists ketamine and MK-801 on intracranial self-stimulation in rats
    Todd M Hillhouse
    Department of Psychology, Virginia Commonwealth University, PO Box 842018, 806 West Franklin Street, Richmond, 23284, VA, USA
    Psychopharmacology (Berl) 231:2705-16. 2014
    ..The noncompetitive NMDA antagonist ketamine produces rapid antidepressant effects in treatment-resistant patients suffering from major depressive and bipolar disorders. However, abuse liability is a concern...
  97. pmc Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA
    Kimberly A Kempadoo
    Ernest Gallo Clinic and Research Center, Emeryville, California 94608, USA
    J Neurosci 33:7618-26. 2013
    ..The striking behavioral and electrophysiological effects of NT and glutamate highlight the LH to VTA pathway as an important component of reward...
  98. pmc Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence
    Xia Li
    Department of Psychiatry, M C 0603, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Neuropharmacology 66:12-23. 2013
    ..AMN082 or other mGlu7 receptor allosteric agonists may have potential as novel pharmacotherapies for cocaine addiction. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'...
  99. ncbi Effects of the neuroactive steroid allopregnanolone on intracranial self-stimulation in C57BL/6J mice
    Eric W Fish
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, CB 7178, 104 Manning Dr, Chapel Hill, NC, 27599, USA
    Psychopharmacology (Berl) 231:3415-23. 2014
    ..Intracranial self-stimulation (ICSS) is an operant behavioral technique that detects changes in the sensitivity of brain reward circuitry following drug administration...
  100. ncbi Operant conditioning of hippocampal theta: dissociating reward from performance deficits
    B D Fantie
    Dalhousie University, Halifax, Nova Scotia, Canada
    Behav Neurosci 101:626-33. 1987
    ..Dopaminergic blocking at low doses reduces the rewarding value of brain stimulation at the level of the lateral hypothalamus. The method described in this report has wide applicability...
  101. ncbi Immunohistochemical characterisation of Fos-positive cells in brainstem monoaminergic nuclei following intracranial self-stimulation of the medial forebrain bundle in the rat
    Y Ishida
    Department of Psychiatry, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Eur J Neurosci 13:1600-8. 2001
    ..These results suggest that ICSS of the MFB induces differential Fos expression within monoaminergic and GABAergic neurons in brainstem monoaminergic nuclei under modulation by glutamatergic afferents...

Research Grants63

  1. Modulators of Metabotropic Glutamate Receptor Subtype 2 for Cocaine Dependence
    Nicholas Cosford; Fiscal Year: 2009
    ..The proposed research is a highly innovative, significant and timely multidisciplinary project that draws on the expertise of the research team and addresses the requirements of this RFA. ..
  2. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..We will make chemical measurements of O2 and 5-HT and electrophysiological measurements of GABAergic neurons in this region with the same electrode during ICSS. ..
  3. Neurobiological mechanisms of nicotine reinforcement: Role of the nucleus tractus
    LUIS MIGUEL TUESTA; Fiscal Year: 2012
    ..Results from the experiments outlined in this proposal will increase our basic understanding of nicotine addiction, and may provide exciting targets for the development of novel therapeutics for smoking cessation. ..
  4. Adolescent Alcohol,Dysregulated Stress System, and PTSD Vulnerability
    GERHARD H SCHULTEIS; Fiscal Year: 2013
    ....
  5. Endocannabinoid Discrimination
    Jenny L Wiley; Fiscal Year: 2013
    ....
  6. The Role of CLOCK in Ethanol-Related Behaviors
    Angela Renee Ozburn; Fiscal Year: 2012
    ..The funding of this NRSA application is instrumental in my success. ..
  7. Endocannabinoid modulation of pain-depressed behavior
    LAURA J SIMSELLEY; Fiscal Year: 2013
    ....
  8. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2011
    ..Such studies will identify novel therapeutic targets for the treatment of nicotine dependence and habitual tobacco smoking in humans. ..
  9. Roles of Nucleus Accumbens CREB and Kappa Function in Depression
    William A Carlezon; Fiscal Year: 2013
    ..We will also test the hypothesis that KOR disruption blocks stress-induced alterations in microRNA (miR) expression in the mesocorticolimbic system. This work may provide a basis for improved diagnostics and therapeutics. ..
  10. Sex differences in the aversive effects of kappa-opioid receptor activation
    Elena H Chartoff; Fiscal Year: 2013
    ....
  11. Targeted Library Synthesis and Screening: Allosteric Modulators of Transporters
    Subramaniam Ananthan; Fiscal Year: 2013
    ..These studies should reveal the potential of the allosteric ligands of DAT as treatment agents for substance abuse and psychiatric disorders. ..
  12. Effects of Acute and Chronic Alcohol on Brain Reward in Mice
    C J Malanga; Fiscal Year: 2013
    ....
  13. Group II mGluR antagonists and negative modulators in depression
    Athina Markou; Fiscal Year: 2013
    ..This project is very innovative and promises to have a highly significant overall impact by promoting the discovery of new treatments for this devastating disorder. ..
  14. GABAA subtype-specific pharmacological modulation of reward-related behavior
    Uwe Rudolph; Fiscal Year: 2010
    ....
  15. A novel rodent model of dopamine agonist-induced impulsive control disorders
    T Celeste Napier; Fiscal Year: 2012
    ..Moreover, we predict this model will provide a completely new means to rapidly screen compounds under development as therapeutics for CNS disorders for potential of the compound to induced ICDs. ..
  16. Nicotine dependence and central adiposity signaling
    ADRIAAN WILLEM BRUIJNZEEL; Fiscal Year: 2010
    ..A better understanding of the brain mechanisms underlying post-cessation weight gain may contribute to new treatments for post-cessation weight gain and thereby improve smoking cessation rates. ..
  17. Drug Abuse, Schizophrenia, NMDA Receptor
    Joseph T Coyle; Fiscal Year: 2013
    ..Finally, we will determine whether behavioral abnormalities in the SR-/- mice can be reversed by treatments that replace the deficient D-serine. ..
  18. Prenatal ethanol exposure effects on reward circuitry and ethanol consumption
    JAMES PATRICK RICE; Fiscal Year: 2012
    ..The results of these experiments will lead to a better understanding of how learning and memory related to alcohol are impacted by early development insults, and provide a therapeutic target for future research and treatments. ..
  19. Sexual Modulation of HIV-Revelant Vaginal Immunity
    Sari M van Anders; Fiscal Year: 2013
    ....
  20. Role of D3 receptors in drug-induced impulsivity in a rat model of Parkinson's di
    STEPHANIE E TEDFORD; Fiscal Year: 2013
    ....
  21. Nicotine withdrawal and relapse: role of neuroadaptations in brain stress systems
    ADRIAAN WILLEM BRUIJNZEEL; Fiscal Year: 2012
    ..These novel treatments may aid in improving smoking cessation rates. ..
  22. Dysregulation of glial glutamate transmission as a model of depressive illness
    ANITA JEAN BECHTHOLT GOMPF; Fiscal Year: 2011
    ..This work has a high likelihood of facilitating the development of new more effective treatment strategies. ..
  23. Combined Voltammetry/Electrophysiology in Behaving Rats
    Regina M Carelli; Fiscal Year: 2013
    ..The information obtained from the present application will provide insight into the neurobiological mechanisms mediating cocaine addiction and thereby aid in the development of pharmacological agents to treat human drug addiction. ..
  24. Role of dopamine signaling in the mood-related effects of salvinorin A
    Elena H Chartoff; Fiscal Year: 2013
    ..The goal of the proposed studies is to determine if salvinorin A modulates brain reward systems by altering dopamine-mediated signaling in the nucleus accumbens, a brain region involved in the regulation of reward. ..
  25. Antidepressant-like and reward-related functions of a2-containing GABAA receptors
    Uwe Rudolph; Fiscal Year: 2010
    ....
  26. Mechanisms of Alcohol Reward in a Humanized OPRM1 Mouse Model
    JOHN ELLIOTT ROBINSON; Fiscal Year: 2013
    ..The proposed training plan will provide a solid educational and professional foundation on which to pursue a career as a physician-scientist in the field of addiction medicine. ..
  27. Mechanisms of Psychostimulant Abuse
    CLAYTON THOMAS BAUER; Fiscal Year: 2013
    ....
  28. Neurobiology and Treatment of Pain
    SIDNEY S NEGUS; Fiscal Year: 2013
    ..We predict that pain will stimulate CREB phosphorylation and dynorphin synthesis in nucleus accumbens, and that these pain effects will be blocked by affective analgesics. ..
  29. Examination of the Functional Consequences of HIV-1 Tat on Motivated Behavior
    Laurence L Miller; Fiscal Year: 2013
    ....
  30. Kappa opioid antagonists: synthesis, potency, selectivity, and time-course
    William A Carlezon; Fiscal Year: 2011
    ..biaryl/diaryl ether agents and the standard KOR antagonist JDTic will be evaluated in the rat intracranial self stimulation test to provide information about in vivo potency and time course of KOR blockade...
  31. Development of GABABeta Receptor Compounds for Nicotine Dependence
    Athina Markou; Fiscal Year: 2013
    ..This multidisciplinary research program integrates the complementary expertise of the participating scientists to provide innovative potential therapeutics for nicotine dependence in humans. ..
  32. Effects of Cannabinoids on Pain-Stimulated and Pain-Depressed Behavior in Rats
    Andrew J Kwilasz; Fiscal Year: 2013
    ..The primary goal of this project is to assess antinociceptive effects of CBs using a model that may be more predictive of analgesia in humans. ..
  33. Efficacy of Novel Triple Uptake Inhibitors in Treating Alcoholism and Depression
    Harry L June; Fiscal Year: 2013
    ..abstract_text> ..
  34. The Neural Regulation of Negative Affect in a New Model of Cocaine Seeking
    Robert A Wheeler; Fiscal Year: 2013
    ..abstract_text> ..
  35. Stimulation of Tumorigenesis by NKG2D
    Thomas Spies; Fiscal Year: 2013
    ..twist, cancer cells themselves express NKG2D receptors and may thus exploit the presence of its ligands for self stimulation of tumor growth...
  36. Development of Orexin-1 Receptor Antagonists to Prevent Drug Relapse
    Paul J Kenny; Fiscal Year: 2011
    ..Such an integrated multidisciplinary research plan will capitalize on the unique drug discovery capabilities at Scripps Florida, and promises to yield novel therapeutic entities for the prevention of relapse in human addicts. ..
  37. Discovery and development of nociceptin receptor ligands in alcohol dependence
    CLAES ROBERT WAHLESTEDT; Fiscal Year: 2010
    ..Our goal is to generate a novel therapeutic entity to be used in alcohol research and with the potential of ultimately translating into the clinic as efficacious treatments for alcohol dependence and abuse. ..
  38. DRUGS OF ABUSE, DOPAMINE & CONTROL BY BRAIN PEPTIDES
    BARTLEY HOEBEL; Fiscal Year: 1991
    ....
  39. MARIJUANA & DOPAMINE/ENKEPHALIN BRAIN REWARD SYSTEMS
    ELIOT GARDNER; Fiscal Year: 1992
    ..The health relatedness is clear, given that marijuana is the most widely used illicit drug in the United States, and given the evidence for health consequences of chronic marijuana abuse...
  40. "Post-partum steroid withdrawal-induced depression"
    REBECCA CRAFT; Fiscal Year: 2006
    ..Findings from the proposed model will enhance our understanding of the etiology of PPD and possibly lead to improved treatment options. ..
  41. Inflammatory Processes and Depression in a Syngeneic Model of Ovarian Cancer
    DONALD LAMKIN; Fiscal Year: 2009
    ....
  42. Optogenetic Manipulation of Brain Reward
    Luis de Lecea; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: This proposal will use state of the art methods to identify neuronal structures involved in brain reward function. ..
  43. CELLULAR NEUROBIOLOGY OF ENDORPHINS: ROLE IN DRUG ABUSE
    Steven Henriksen; Fiscal Year: 1992
    ..e. hippocampus and nucleus accumbens) in awake animals involved in a heroin self-administration protocol. Using this paradigm the cellular correlates of opiate reward phenomena will be investigated in a more relevant preparation...
  44. Bupropion and Secondary Motivational Effects of Nicotine
    ANTHONY RAUHUT; Fiscal Year: 2005
    ..S. population to 12% and 16%, accordingly. ..
  45. SELF-ADMINISTRATION OF BRAIN STIMULATION REWARD
    JAMES STELLAR; Fiscal Year: 1993
    ..Because this is a novel approach a short grant format has been selected. Future grant proposals will focus on the application of psychophysical methods to cocaine self-administration...
  46. Role of dopamine D1 receptors in morphine withdrawal
    Elena Chartoff; Fiscal Year: 2006
    ..This work may lead to new pharmacotherapies that can alleviate aversive and dysphoric states associated with opiate withdrawal and perhaps reduce relapse to drug taking. ..
  47. DRUG MODULATION OF COCAINE-INDUCED CHANGES IN BSR
    Robert Frank; Fiscal Year: 1990
    ..Finally, the influence of imipramine on cocaine's effects will be assessed to determine whether this drug, which has been proposed as a treatment for cocaine dependence, alters cocaine-induced euphoria and/or dysphoria...
  48. OPIATE ACTION ON SEPTO HIPPOCAMPAL NEURONS
    Meenakshi Alreja; Fiscal Year: 1999
    ....
  49. BEHAVIORAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS
    STEPHEN HOLTZMAN; Fiscal Year: 2002
    ..Acute agonist-induced sensitization to opioid antagonists appears to be an exquisite example of neuronal plasticity, reflecting the first hours of the drug-receptor interactions that lead to chronic physical dependence upon opioids. ..
  50. Maternal Separation: Rat Model of Opioid Vulnerability
    STEPHEN HOLTZMAN; Fiscal Year: 2006
    ..abstract_text> ..
  51. GLUTAMATERIC MECHANISMS OF DRUG-CONDITIONED BEHAVIOR
    Robert Balster; Fiscal Year: 2004
    ....
  52. Metabolic regulation of midbrain dopamine neurons
    Robert MacKenzie; Fiscal Year: 2005
    ..Completion of the project will provide the necessary tools for a second phase project in which specific genes will be examined for their role in mediating the direct or indirect action of leptin on midbrain DA neurons. ..
  53. NEURAL SUBSTRATE OF REWARDING BRAIN STIMULATION
    Meg Waraczynski; Fiscal Year: 1999
    ....
  54. PATHOPHYSIOLOGIC MECHANISMS OF LUNG INJURY AFTER BMT
    Kenneth Cooke; Fiscal Year: 2000
    ..In step two, activated T cells undergo self stimulation and proliferation while they simultaneously prime pulmonary macrophages by secreting Interferon-gamma (IFNy)...
  55. A Simple Behavioral Model of Cocaine Withdrawal in Rats
    WILLIAM CARLEZON; Fiscal Year: 2002
    ..Together, these studies may facilitate the identification and development of innovative treatments that more effectively treat the symptoms of withdrawal from cocaine and other drugs of abuse. ..
  56. SELF-STIMULATION, SELF-INJECTION AND DRUGS OF ABUSE
    BARTLEY HOEBEL; Fiscal Year: 1980
    ..We will also study the interactions between norepinephrine and opiods in the control of feeding, self-stimulation and self-injection...
  57. LOCALIZATION OF CNS SITES OF ACTION OF ABUSED DRUGS
    Solomon Steiner; Fiscal Year: 1980
    ..We have already performed a variety of experiments looking at the effects of amphetamine and morphine on different neuroanatomical sites that support ICSS...
  58. NEUROPSYCHOPHARMACOLOGICAL STUDIES OF ATTENTION
    Conan Kornetsky; Fiscal Year: 1980
    ..g., amphetamine, cocaine, phencyclidine) on intracranial self stimulation thresholds...
  59. CATECHOLAMINE UNIT ACTIVITY AND POSITIVE REINFORCERS
    DWIGHT GERMAN; Fiscal Year: 1980
    ..e., chocolate milk). Such a research project should provide a clearer understanding of the functional significance of the neurons whose malfunctions have been implicated in such disorders as schizophrenia and mania/depression...
  60. MORPHINE, DRIVEN BEHAVIOR, REWARD, & NEURON ACTIVITY
    MARIANNE OLDS; Fiscal Year: 1980
    ..The ultimate aim is to contribute to an understanding of opiate action on the one hand and to a central motivational mechanism on the other. ..
  61. SENSORIMOTOR PLASTICITY--ROLE OF D1 AND D2 RECEPTORS
    John Bruno; Fiscal Year: 1993
    ..The results obtained from this proposal will provide insights into the neurochemical and neuroanatomical bases for plasticity in sensorimotor and self-stimulation behavior and how age constrains the extent of this plasticity...
  62. The Neural Regulation of Negative Affect in a New Model of Cocaine Seeking
    Robert A Wheeler; Fiscal Year: 2010
    ..The PI will investigate the motivational properties and neural underpinnings of this state that promotes drug seeking. Such investigations could lead to new pharmacotherapies aimed at disrupting the motivation to seek cocaine. ..
  63. Impulsivity and Neural Processing of Rewards
    MARK TODTENKOPF; Fiscal Year: 2005
    ..abstract_text> ..