psychoneuroimmunology

Summary

Summary: The field concerned with the interrelationship between the brain, behavior and the immune system. Neuropsychologic, neuroanatomic and psychosocial studies have demonstrated their role in accentuating or diminishing immune/allergic responses.

Top Publications

  1. ncbi [Psychological interventions and their immune consequences]
    Karol Mausch

    Psychiatr Pol 36:945-52. 2002
  2. ncbi Receptor regulation in neuroendocrine-immune communication: current knowledge and future perspectives
    Cobi J Heijnen
    Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Brain Behav Immun 21:1-8. 2007
  3. ncbi Understanding the interaction between psychosocial stress and immune-related diseases: a stepwise progression
    Margaret E Kemeny
    Health Psychology Program, Department of Psychiatry, University of California, San Francisco, CA 94143 0848, USA
    Brain Behav Immun 21:1009-18. 2007
  4. ncbi Psychoneuroimmunology and psychosomatic medicine: back to the future
    Janice K Kiecolt-Glaser
    Department of Psychiatry, Ohio State University, Columbus, OH 43210, USA
    Psychosom Med 64:15-28. 2002
  5. ncbi Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology
    Janice K Kiecolt-Glaser
    Department of Psychiatry The Ohio State University College of Medicine, 1670 Upham Drive, Columbus, Ohio 43210, USA
    Annu Rev Psychol 53:83-107. 2002
  6. ncbi A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities
    Thaddeus W W Pace
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Behav Immun 25:6-13. 2011
  7. ncbi Research on psychoneuroimmunology: tai chi as a stress management approach for individuals with HIV disease
    Jo Lynne W Robins
    Integrating Wellness, Inc, Richmond, VA 23235, USA
    Appl Nurs Res 19:2-9. 2006
  8. ncbi The psychoneuroimmunology of depression
    Brian E Leonard
    Pharmacology Department, National University of Ireland, Galway, Ireland
    Hum Psychopharmacol 24:165-75. 2009
  9. ncbi Resources, stress, and immunity: an ecological perspective on human psychoneuroimmunology
    Suzanne C Segerstrom
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY, 40506 0044, USA
    Ann Behav Med 40:114-25. 2010
  10. ncbi Infection-induced viscerosensory signals from the gut enhance anxiety: implications for psychoneuroimmunology
    Lisa E Goehler
    Department of Psychology, University of Virginia, Charlottesville, VA 22904 4400, USA
    Brain Behav Immun 21:721-6. 2007

Research Grants

  1. Preterm Birth: Psychoneuroimmunology in Hispanics
    ROBERTA RUIZ; Fiscal Year: 2005
  2. Psychoneuroimmunology of T Cell Activation
    Steve Zalcman; Fiscal Year: 2004
  3. Psychoneuroimmunology: Preterm Birth in Hispanics
    ROBERTA RUIZ; Fiscal Year: 2009
  4. Psychoneuroimmunology: Preterm Birth in Hispanics
    Roberta Jeanne Ruiz; Fiscal Year: 2010
  5. Psychoneuroimmunology: Preterm Birth in Hispanics
    Roberta Jeanne Ruiz; Fiscal Year: 2010
  6. Diet and Breast Density over Time in US Chinese Women
    Marilyn Tseng; Fiscal Year: 2009
  7. PNI and Decision Making in Women Diagnosed with DCIS
    LINDA JANUSEK; Fiscal Year: 2007
  8. Cognitive Behavioral Effects on Sleep, Pain, and Cytokines in Gynecologic Cancer
    Deidre B Pereira; Fiscal Year: 2010
  9. Complicated Grief in Older Adults: Physiological Substrates of Emotion Regulation
    MARY FRANCES O CONNOR; Fiscal Year: 2007
  10. The Rochester Center for Mind-Body Research
    Jan Moynihan; Fiscal Year: 2007

Detail Information

Publications160 found, 100 shown here

  1. ncbi [Psychological interventions and their immune consequences]
    Karol Mausch

    Psychiatr Pol 36:945-52. 2002
    b>Psychoneuroimmunology is a new tendency in science which integrates medicine and social sciences...
  2. ncbi Receptor regulation in neuroendocrine-immune communication: current knowledge and future perspectives
    Cobi J Heijnen
    Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Brain Behav Immun 21:1-8. 2007
    ..Finally, consequences of alterations in GRK2 during (neuro)-inflammatory diseases are discussed...
  3. ncbi Understanding the interaction between psychosocial stress and immune-related diseases: a stepwise progression
    Margaret E Kemeny
    Health Psychology Program, Department of Psychiatry, University of California, San Francisco, CA 94143 0848, USA
    Brain Behav Immun 21:1009-18. 2007
    ..This knowledge will provide the basis for new therapeutic pharmacological and non-pharmacological behavioral approaches to the treatment of chronic diseases via specific modulation of nervous system-immune system communication...
  4. ncbi Psychoneuroimmunology and psychosomatic medicine: back to the future
    Janice K Kiecolt-Glaser
    Department of Psychiatry, Ohio State University, Columbus, OH 43210, USA
    Psychosom Med 64:15-28. 2002
    ..This article speculates on future directions for psychoneuroimmunology research, after reviewing the history of the field.
  5. ncbi Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology
    Janice K Kiecolt-Glaser
    Department of Psychiatry The Ohio State University College of Medicine, 1670 Upham Drive, Columbus, Ohio 43210, USA
    Annu Rev Psychol 53:83-107. 2002
    ..Resources such as close personal relationships that diminish negative emotions enhance health in part through their positive impact on immune and endocrine regulation...
  6. ncbi A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities
    Thaddeus W W Pace
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Behav Immun 25:6-13. 2011
    ..This short article reviews immune alterations in PTSD, and considers possible mechanisms by which such changes may be related to neuroendocrine alterations and medical comorbidities of PTSD...
  7. ncbi Research on psychoneuroimmunology: tai chi as a stress management approach for individuals with HIV disease
    Jo Lynne W Robins
    Integrating Wellness, Inc, Richmond, VA 23235, USA
    Appl Nurs Res 19:2-9. 2006
    b>Psychoneuroimmunology is a framework for mind-body practice and research that combines cutting-edge scientific exploration with holistic philosophy to appreciate and understand stress responses...
  8. ncbi The psychoneuroimmunology of depression
    Brian E Leonard
    Pharmacology Department, National University of Ireland, Galway, Ireland
    Hum Psychopharmacol 24:165-75. 2009
    ..Such changes may provide evidence for the link between chronic depression and dementia in later life...
  9. ncbi Resources, stress, and immunity: an ecological perspective on human psychoneuroimmunology
    Suzanne C Segerstrom
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY, 40506 0044, USA
    Ann Behav Med 40:114-25. 2010
    ..In conclusion, ecological models may aid in understanding the relationship between stress and immunity...
  10. ncbi Infection-induced viscerosensory signals from the gut enhance anxiety: implications for psychoneuroimmunology
    Lisa E Goehler
    Department of Psychology, University of Virginia, Charlottesville, VA 22904 4400, USA
    Brain Behav Immun 21:721-6. 2007
    ....
  11. ncbi The psychoneuroimmunology of postpartum depression
    Elizabeth J Corwin
    The Ohio State University, Columbus, Ohio 43210, USA
    J Womens Health (Larchmt) 17:1529-34. 2008
    ..The purpose of this paper is to review the psychoneuroimmunology of PPD...
  12. ncbi Theoretical accounts of Gulf War Syndrome: from environmental toxins to psychoneuroimmunology and neurodegeneration
    E Ferguson
    School of Psychology, University of Nottingham, Nottingham, NG7 2RD, UK
    Behav Neurol 13:133-47. 2001
    ..This position contrasts with other immunological accounts of GWS that suggest that the immune system demonstrates a shift to a Th2 (allergy) profile. Evidence pertaining to these two contrasting positions is reviewed...
  13. ncbi Mind-body interface: the role of n-3 fatty acids in psychoneuroimmunology, somatic presentation, and medical illness comorbidity of depression
    Kuan Pin Su
    Department of General Psychiatry, China Medical University Hospital, No 2, Yuh Der Road, Taichung 404, Taiwan
    Asia Pac J Clin Nutr 17:151-7. 2008
    ..Indeed, the role of n-3 PUFAs in immunity and mood function supports the promising psychoneuroimmunologic hypothesis of depression and provides an excellent interface shared by body and mind...
  14. ncbi Stressed to death: implication of lymphocyte apoptosis for psychoneuroimmunology
    Yufang Shi
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 661 Hoes Lane, Piscataway 08854, USA
    Brain Behav Immun 17:S18-26. 2003
    ....
  15. ncbi Psychoneuroimmunology
    Francisco Tausk
    Department of Dermatology, University of Rochester, Rochester, New York 14642, USA
    Dermatol Ther 21:22-31. 2008
    b>Psychoneuroimmunology (PNI) is a discipline that has evolved in the last 40 years to study the relationship between immunity, the endocrine system, and the central and peripheral nervous systems...
  16. ncbi Psychoneuroimmunology: psychological influences on immune function and health
    Janice K Kiecolt-Glaser
    Department of Psychiatry and Institute for Behavioral Medicine Research, Ohio State University College of Medicine, Columbus 43210, USA
    J Consult Clin Psychol 70:537-47. 2002
    This review focuses on human psychoneuroimmunology studies published in the past decade...
  17. ncbi Innate immunity at the forefront of psychoneuroimmunology
    Robert Dantzer
    Integrative Neurobiology, Bordeaux, France
    Brain Behav Immun 18:1-6. 2004
    The last 15 years of research in psychoneuroimmunology have been marked by a renewed interest in the mechanisms of inflammation and participation of the brain in these mechanisms...
  18. ncbi The integration of cardiovascular behavioral medicine and psychoneuroimmunology: new developments based on converging research fields
    Willem J Kop
    Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Brain Behav Immun 17:233-7. 2003
    ..g., mental stress and anger) can promote myocardial ischemia and plaque rupture. The psychoneuroimmunological pathways are described for each of these three types of psychological risk factors for acute coronary syndromes...
  19. ncbi Comparative psychoneuroimmunology: evidence from the insects
    Shelley A Adamo
    Dalhousie University, Canada
    Behav Cogn Neurosci Rev 5:128-40. 2006
    ..Because insects occupy a wide range of ecological niches, they will be useful in examining how some immune-behavioral interactions are sculpted by an animal's behavioral ecology...
  20. ncbi The promotion of tumor metastasis by surgery and stress: immunological basis and implications for psychoneuroimmunology
    Shamgar Ben-Eliyahu
    Biopsychology Research Unit, Department of Psychology, Tel Aviv University, Israel
    Brain Behav Immun 17:S27-36. 2003
    This mini-review emphasizes a psychoneuroimmunology (PNI) perspective of the hypothesis that stress and surgical excision of the primary tumor can promote tumor metastasis...
  21. ncbi Psychoneuroimmunology in critically ill patients
    Freda DeKeyser
    Hadassah Hebrew University, School of Nursing, Jerusalem, Israel
    AACN Clin Issues 14:25-32. 2003
    b>Psychoneuroimmunology is the study of the interactions among behavior, neural, and endocrine functions and the immune system...
  22. ncbi Psycho-oncology and cancer: psychoneuroimmunology and cancer
    J K Kiecolt-Glaser
    Department of Psychiatry, The Ohio State University Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio, USA
    Ann Oncol 13:165-9. 2002
  23. ncbi Invertebrate studies and the evolution of comparative psychoneuroimmunology
    Arnaud Aubert
    DESCO, , 37200 Tours, France
    Brain Behav Immun 21:290-1. 2007
  24. ncbi The unknown mechanism of the overtraining syndrome: clues from depression and psychoneuroimmunology
    Lawrence E Armstrong
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, Connecticut 06269-1110, USA
    Sports Med 32:185-209. 2002
    ..Novel recommendations are proposed for the treatment of overtrained athletes with antidepressant medications, and guidelines are provided for psychological counselling...
  25. ncbi Brain-immune communication psychoneuroimmunology of multiple sclerosis
    S Kern
    Technische Universitat Dresden, Klinik und Poliklinik fur Neurologie, Multiple Sklerose Zentrum Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Mult Scler 14:6-21. 2008
    ..While the exact mechanisms for these phenomena are still poorly understood, the young discipline of psychoneuroimmunology (PNI), which focuses on the mechanism underlying the brain to immune crosstalk, might offer some insights ..
  26. ncbi Human psychoneuroimmunology: 20 years of discovery
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, 300 Medical Plaza, Suite 3 109, Los Angeles, CA 90095 7057, USA
    Brain Behav Immun 22:129-39. 2008
    An important component of psychoneuroimmunology research is to reveal the myriad ways that behaviors and health are inter-related, with a focus on the immunological mechanisms that underlie these interactions...
  27. ncbi On the development of psychoneuroimmunology
    R Ader
    Center for Psychoneuroimmunology Research, Department of Psychiatry, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Eur J Pharmacol 405:167-76. 2000
    b>Psychoneuroimmunology, the study of interactions among behavioral, neural and endocrine, and immune processes, coalesced as an interdisciplinary field of study in the late 1970s...
  28. ncbi The measurement of stress-related immune dysfunction in psychoneuroimmunology
    K Vedhara
    Department of Experimental Psychology, University of Bristol, Clifton, UK
    Neurosci Biobehav Rev 23:699-715. 1999
    ..e. the field of Psychoneuroimmunology (PNI)...
  29. ncbi Stress-associated immune dysregulation and its importance for human health: a personal history of psychoneuroimmunology
    Ronald Glaser
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Institute for Behavioral Medicine Research, The Ohio State University Medical Center, USA
    Brain Behav Immun 19:3-11. 2005
    ..The field of psychoneuroimmunology (PNI) is a field of research that deals with the complex interactions between the central nervous system, ..
  30. ncbi Psychobiological responses to social threat: evolution of a psychological model in psychoneuroimmunology
    Margaret E Kemeny
    Health Psychology Program, Department of Psychiatry, University of California San Francisco School of Medicine, 3333 California Street, Suite 465, San Francisco, CA 94143 0848, USA
    Brain Behav Immun 23:1-9. 2009
    ..The role of cognitive processes in shaping the physiological response to the social world will be emphasized...
  31. ncbi Psychoneuroimmunology and cancer: fact or fiction?
    J K Kiecolt-Glaser
    Department of Psychiatry, Ohio State University College of Medicine, Columbus 43210, USA
    Eur J Cancer 35:1603-7. 1999
    ..These studies and others suggest that psychological or behavioural factors may influence the incidence or progression of cancer through psychosocial influences on immune function and other physiological pathways...
  32. ncbi Psychoneuroimmunology and health psychology: an integrative model
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, Iowa 52242, USA
    Brain Behav Immun 17:225-32. 2003
    ..These interactions are discussed in the context of aging...
  33. ncbi Psychoneuroimmunology: new avenues of research for the twenty-first century
    Paolo Prolo
    UCLA School of Dentistry, and Dental Research Institute, Los Angeles, California 90095, USA
    Ann N Y Acad Sci 966:400-8. 2002
    b>Psychoneuroimmunology (PNI) investigates the relations between the psychophysiological and immunophysiological dimensions of living beings...
  34. ncbi Psychoneuroimmunology
    N Cohen
    Department of Microbiology and Immunology, University of Rochester, New York 14642, USA
    Environ Health Perspect 105:527-9. 1997
    ..an overview of the questions and hypotheses generated by a working group exploring the application of psychoneuroimmunology to chemical sensitivities...
  35. ncbi Physiology of psychoneuroimmunology: a personal view
    Hugo O Besedovsky
    Department of Immunophysiology, Institute of Physiology and Pathophysiology, Deutschhausstrasse 2, 35037 Marburg, Germany
    Brain Behav Immun 21:34-44. 2007
    ..We also discuss increasing evidence that brain-born cytokines play an important role in brain physiology and in the integration of the immune-neuro-endocrine network...
  36. ncbi Type C coping, alexithymia, and heart rate reactivity are associated independently and differentially with specific immune mechanisms linked to HIV progression
    Lydia R Temoshok
    Institute of Human Virology, Department of Medicine, University of Maryland School of Medicine, 725 West Lombard Street, N 146, Baltimore, MD 21201, USA
    Brain Behav Immun 22:781-92. 2008
    ....
  37. ncbi Stress and depression-induced immune dysfunction: implications for the development and progression of cancer
    Edna Maria Vissoci Reiche
    Department of Pathology, Clinical Analysis and Toxicology, State University of Londrina, Londrina, Parana, Brazil
    Int Rev Psychiatry 17:515-27. 2005
    ..A better understanding of the bidirectional communication between the neuroendocrine and immune systems could contribute to novel clinical and treatment strategies in oncology...
  38. ncbi Immunity, neuroglia and neuroinflammation in autism
    Carlos A Pardo
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int Rev Psychiatry 17:485-95. 2005
    ..A better understanding of the role of neuroinflammation in the pathogenesis of autism may have important clinical and therapeutic implications...
  39. ncbi Written disclosure of experiences with racial discrimination and antibody response to an influenza vaccine
    Cinnamon Stetler
    University of British Columbia, Vancouver, Canada
    Int J Behav Med 13:60-8. 2006
    ..The attributional ambiguity sometimes associated with racism may inhibit the benefits of disclosure interventions for these types of stressors...
  40. ncbi TNF-alpha levels in cancer patients relate to social variables
    Phillip T Marucha
    Department of Periodontics, College of Dentistry, University of Illinois at Chicago, USA
    Brain Behav Immun 19:521-5. 2005
    ..This is the first study to link changes in patient social relations with a cancer-relevant immune variable...
  41. ncbi Implementing a comprehensive approach to the study of health dynamics using the psychoneuroimmunology paradigm
    Nancy L McCain
    Department of Adult Health, Virginia Commonwealth University, Richmond, VA 23298, USA
    ANS Adv Nurs Sci 28:320-32. 2005
    This article addresses psychoneuroimmunology (PNI) as an integrative paradigm for advancing both theoretical and empirical knowledge of physiological patterns that contribute to the dynamics of health...
  42. ncbi [Heavy burdens and complex disease--an integrated perspective]
    Anna Luise Kirkengen
    Institutt for samfunnsmedisinske fag Universitetet i Tromsø
    Tidsskr Nor Laegeforen 127:3228-31. 2007
    ..By regarding human beings as persons who experience bodily and who both create and convey meaning, we claim to have transgressed the mind-body-dichotomy in complex disease development. The dichotomy converges in the living body...
  43. ncbi The mediation effect of posttraumatic stress disorder symptoms on the relationship of intimate partner violence and IFN-gamma levels
    Anne B Woods
    Johns Hopkins University School of Nursing, 525 N Wolfe Street, Room 442, Baltimore, Maryland 21205, USA
    Am J Community Psychol 36:159-75. 2005
    ..Although an association between psychological stress and altered immune function has been shown, IPV studies have not investigated this relationship...
  44. ncbi Biological underpinnings of health alterations in women with PTSD: a sex disparity
    Jessica M Gill
    Johns Hopkins University School of Nursing, Baltimore, MD 21205, USA
    Biol Res Nurs 7:44-54. 2005
    ....
  45. ncbi Unkind cytokines: current evidence for the potential role of cytokines in immune-mediated depression
    Michele L Pucak
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287-7121, USA
    Int Rev Psychiatry 17:477-83. 2005
    ....
  46. ncbi It takes nerve to tell T and B cells what to do
    Nicholas W Kin
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Leukoc Biol 79:1093-104. 2006
    ..We will also discuss how dysregulation of this line of communication between the nervous and immune systems might contribute to disease development and progression...
  47. ncbi Brain-immune communication pathways
    Ning Quan
    Institute of Behavioral Medicine, Ohio State University, USA
    Brain Behav Immun 21:727-35. 2007
    ..These and other pathways have established the existence of a neuroimmune axis, but raise new questions on how they act and interact with one another...
  48. ncbi Psychoneuroimmunology--cross-talk between the immune and nervous systems
    Tjalf Ziemssen
    MS Center Dresden, Neuroimmunological laboratory, Neurological Clinic, University Clinic Carl Gustav Carus Dresden, Fetscherstr 74, 01307, Dresden, Germany
    J Neurol 254:II8-11. 2007
    b>Psychoneuroimmunology is a relatively new field of study that investigates interactions between behaviour and the immune system, mediated by the endocrine and nervous systems...
  49. ncbi The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis
    Andrew Steptoe
    Psychobiology Group, Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1 6BT, UK
    Brain Behav Immun 21:901-12. 2007
    ..The acute stress-induced inflammatory response may have implications for future health, and has become an important topic of psychoneuroimmunological research...
  50. ncbi Psychoneuroimmunology and related mechanisms in understanding health disparities in vulnerable populations
    Teresita L Briones
    University of Illinois at Chicago, USA
    Annu Rev Nurs Res 25:219-56. 2007
    ..Given that the relevant literature on these topics is vast, the presentation in this chapter will serve to highlight primary references that reflect state of the science in these systems of focus...
  51. ncbi Depressive disorders and immunity: 20 years of progress and discovery
    Michael R Irwin
    Cousins Center for Psychoneuroimmunology, University of California Los Angeles, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3 109, Los Angeles, CA, USA
    Brain Behav Immun 21:374-83. 2007
    ..These developments have increasingly put the field of psychoneuroimmunology into a clinical context with important translational implications...
  52. ncbi [Influence of anxiety in diverse cutaneous diseases]
    E Vargas Laguna
    Hospital Clinico San Carlos, IECP, Madrid, Spain
    Actas Dermosifiliogr 97:637-43. 2006
    ..The objective of the current study is to determine the levels of anxiety in patients with dermatological diseases compared to healthy subjects and the degree of anxiety in the different cutaneous diseases...
  53. ncbi Cytokines, infections, stress, and dysphoric moods in breastfeeders and formula feeders
    Maureen W Groer
    University of South Florida College of Nursing, Tampa, USA
    J Obstet Gynecol Neonatal Nurs 35:599-607. 2006
    ..To analyze relationships between stress, moods, and immunity in breastfeeding compared to formula-feeding mothers...
  54. ncbi Individual trajectories in stress covary with immunity during recovery from cancer diagnosis and treatments
    Lisa M Thornton
    Department of Psychology, The Ohio State University, 159 Psychology Building, 1835 Neil Avenue, Columbus, Ohio 43210, USA
    Brain Behav Immun 21:185-94. 2007
    ..These data highlight the importance of subjective stress, particularly stress appraisals, in the immune response to a major stressor...
  55. ncbi Age and neuroinflammation: a lifetime of psychoneuroimmune consequences
    Jonathan P Godbout
    Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Neurol Clin 24:521-38. 2006
    ..Therefore pharmacologic strategies to decrease neuroinflammation associated with infection may be important for improving recovery from sickness and reducing neurobehavioral deficits in the elderly...
  56. ncbi Depression and immunity: inflammation and depressive symptoms in multiple sclerosis
    Stefan M Gold
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3109, Los Angeles, CA 90095, USA
    Neurol Clin 24:507-19. 2006
    ..For example, an inflammatory depression may require different therapeutic approaches than a reactive depression in MS. Future research should aim to characterize these subtypes better with the goal of optimizing treatment...
  57. ncbi Social interactions, stress, and immunity
    Ronit Avitsur
    School of Behavioral Sciences, The Academic College of Tel Aviv Yaffo, Yaffo, Israel
    Neurol Clin 24:483-91. 2006
    ..Thus, individual differences in response to SDR are associated with specific behavioral strategies that can have substantive implications for host resistance to infectious disease...
  58. ncbi Cytokine, sickness behavior, and depression
    Robert Dantzer
    Laboratory of Integrative Neurobiology, CNRS, INRA, University of Bordeaux 2, 33077 Bordeaux Cedex, France
    Neurol Clin 24:441-60. 2006
    ..In addition, a dynamic view of the cellular interactions that occur at the brain sites of cytokine production and action is missing, together with a clarification of the mechanisms that favor the transition toward pathology...
  59. ncbi A biological substrate for somatoform disorders: importance of pathophysiology
    Joel E Dimsdale
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Psychosom Med 69:850-4. 2007
    ..Studies on communication pathways from the immune system to the brain provide exciting new information on the pathophysiology of inflammation-associated symptoms...
  60. ncbi Therapeutic modulation of the psychoneuroimmune system by medical acupuncture creates enhanced feelings of well-being
    Allan Walling
    J Am Acad Nurse Pract 18:135-43. 2006
    ..An explanation of how medical acupuncture accomplishes this stabilization concludes the article...
  61. ncbi [Atopic dermatitis and stress? How do emotions come into skin?]
    A V Mitschenko
    Klinik für Dermatologie und Venerologie, Moskauer Medizinische I M Setschenow Akademie, Moskau
    Hautarzt 59:314-8. 2008
    ..Thereby lamellar body secretion is decreased and epidermal expression of antimicrobial peptides (beta-defensin and cathelicidin) is down-regulated. We review recent investigations in this field...
  62. ncbi Cytokine-induced sickness behavior: where do we stand?
    R Dantzer
    INRA INSERM U394, Bordeaux Cedex, 33077, France
    Brain Behav Immun 15:7-24. 2001
    ..There is clinical and experimental evidence that activation of the brain cytokine system is associated with depression, although the exact relationship between sickness behavior and depression is still elusive...
  63. ncbi Effects of stress management on PNI-based outcomes in persons with HIV disease
    Nancy L McCain
    School of Nursing, Virginia Commonwealth University School of Nursing, Richmond, VA 23298-0567, USA
    Res Nurs Health 26:102-17. 2003
    ..The findings point to a pressing need for further, well-controlled research with these common intervention modalities...
  64. ncbi Psychological adjustment to the melanoma experience
    Deborah A Boyle
    Good Samaritan Regional Medical Center, 1111 E. McDowell Rd, Phoenix, AZ 85006, USA
    Semin Oncol Nurs 19:70-7. 2003
    ..Nurses need to identify an individual's risk for psychological distress and help them enhance coping skills...
  65. ncbi Cytokine-induced sickness behavior
    Keith W Kelley
    Department of Animal Sciences, Laboratory of Immunophysiology, University of Illinois, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana 61801, USA
    Brain Behav Immun 17:S112-8. 2003
    ..Although basic studies in psychoneuroimmunology have defined proinflammatory cytokines as the central mediators of sickness behavior, a much better ..
  66. ncbi Controversies in cancer and the mind: effects of psychosocial support
    Wallace Sampson
    Stanford University School of Medicine, Stanford, CA, USA
    Semin Oncol 29:595-600. 2002
    ..Psychosocial support may result in better adjustment and quality of life, but it does not directly affect the evolution of human cancer...
  67. ncbi Massage therapy as a supportive care intervention for children with cancer
    Deborah Hughes
    Division of Pediatric Oncology, Columbia University Medical Center, Morgan Stanley Children s Hospital of New York Presbyterian, New York, USA
    Oncol Nurs Forum 35:431-42. 2008
    ..To review relevant literature about massage therapy to assess the feasibility of integrating the body-based complementary and alternative medicine (CAM) practice as a supportive care intervention for children with cancer...
  68. ncbi Does the pineal gland have a role in the psychological mechanisms involved in the progression of cancer?
    B D Callaghan
    Department of Anatomical Sciences, University of Adelaide, Adelaide, Australia
    Med Hypotheses 59:302-11. 2002
    ..It is thus hypothesized that the pineal gland, and melatonin, are involved in the mechanism of psychological effects in the promotion of the progress of cancer...
  69. ncbi Psychoneuroimmunology in oral biology and medicine: the model of oral lichen planus
    Paolo Prolo
    UCLA School of Dentistry, and Dental Research Institute, Los Angeles, California 90095, USA
    Ann N Y Acad Sci 966:429-40. 2002
    ..or complement. It is increasingly well characterized and recognized as a model for psychoneuroimmunology research in oral biology and medicine...
  70. ncbi Coping as a multisystem construct associated with pathways mediating HIV-relevant immune function and disease progression
    Lydia R Temoshok
    Department of Medicine, University of Maryland School of Medicine, and The Institute of Human Virology, 725 West Lombard Street, Baltimore, MD 21201, USA
    Psychosom Med 70:555-61. 2008
    ..Based on empirical evidence, the model suggests plausible mechanisms by which coping may be connected to HIV progression/antiprogression factors and immunopathogenesis to affect HIV clinical progression...
  71. ncbi Psychosocial influences on HIV-1 disease progression: neural, endocrine, and virologic mechanisms
    Steve W Cole
    Department of Medicine, Division of Hematology Oncology, UCLA School of Medicine, the Norman Cousins Center, Jonsson Comprehensive Cancer Center, UCLA AIDS Institute, California 90095 1678, USA
    Psychosom Med 70:562-8. 2008
    ..As such, neural and endocrine parameters might provide useful biomarkers for gauging the promise of behavioral interventions and suggest novel adjunctive strategies for controlling HIV-1 disease progression...
  72. ncbi Stress-induced immunomodulation and the implications for health
    Eric V Yang
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University Comprehensive Cancer Center, Institute for Behavioral Medicine Research, The Ohio State University Medical Center, Columbus 43210, USA
    Int Immunopharmacol 2:315-24. 2002
    ..the mechanisms of this bi-directional communication is not yet fully understood, studies in the field of psychoneuroimmunology (PNI) have shown that stress, through the hypothalamic-pituitary-adrenal (HPA) and the sympathetic-adrenal ..
  73. ncbi A temporal framework for understanding the effects of stressful life events on inflammation in patients with multiple sclerosis
    David C Mohr
    Department of Psychiatry and Neurology, University of California, San Francisco, CA 94131, USA
    Brain Behav Immun 20:27-36. 2006
    ..These three hypotheses are not necessarily mutually exclusive. Data on psychosocial mediators and moderators are also briefly reviewed and future research directions are discussed...
  74. ncbi Psychosocial-immune relationships in HIV disease
    D G Cruess
    Department of Psychology, University of Pennsylvania, Philadelphia, 19104-6196, USA
    Semin Clin Neuropsychiatry 6:241-51. 2001
    ..We conclude by suggesting some areas for future research, particularly the study of HIV-positive women...
  75. ncbi Physiological concentrations of dopamine inhibit the proliferation and cytotoxicity of human CD4+ and CD8+ T cells in vitro: a receptor-mediated mechanism
    B Saha
    Signal Transduction and Biogenic Amines Lab, Chittaranjan National Cancer Institute, Calcutta, India
    Neuroimmunomodulation 9:23-33. 2001
    ..CONCLUSION: Results may be of significance to understand the role of peripheral dopamine in human neuroimmune communication in terms of physiological homeostasis in health and disease...
  76. ncbi Aberrant nuclear expression of AP-1 and NFkappaB in lymphocytes of women stressed by the experience of breast biopsy
    M Nagabhushan
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyala University of Chicago Medical Center, Maywood, Illinois 60153, USA
    Brain Behav Immun 15:78-84. 2001
    ..The results of this study suggest that psychological stress may mediate immunosuppression by altering the expression of the transcription factors, AP-1 and NFkappaB...
  77. ncbi Psycho-neuro-immunological treatment of hepatocellular carcinoma with major depression--a single case report
    H Jozuka
    Department of Psychiatry, JMC Stress Medical Laboratory and Jozuka Mental Clinic, Nishio, Aichi, Japan
    Curr Med Res Opin 19:59-63. 2003
    ..While this may be a case of spontaneous regression, the results suggest that a psycho-neuro-immunological approach to treating the patient's depression and cancer was helpful for her recovery...
  78. ncbi Stressful life events and physical health
    Dusica Lecic Tosevski
    Institute of Mental Health, School of Medicine, University of Belgrade, Serbia and Montenegro
    Curr Opin Psychiatry 19:184-9. 2006
    ..This review summarizes the findings of recent researches from selected empirical and nonempirical publications focused on stressful life events and physical health...
  79. ncbi Coping style and immunity in animals: making sense of individual variation
    J M Koolhaas
    Department of Behavioral Physiology, Centre for Behavioral and Cognitive Neuroscience, University Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Brain Behav Immun 22:662-7. 2008
    ..This asks for a more fundamental and translational approach of individual disease vulnerability based on a common biological basis of individual differentiation in behavior and physiology in humans and animals...
  80. ncbi [Atopic dermatitis and psychological stress]
    U Raap
    Klinik und Poliklinik fur Dermatologie und Venerologie, Medizinische Hochschule Hannover
    Hautarzt 54:925-9. 2003
    ..These findings underline the role of immunological changes and a possible suppressed hypothalamic-pituitary-adrenal (HPA) axis closing the loop for the final aggravation of AD...
  81. ncbi Socioeconomic status, C-reactive protein, immune factors, and responses to acute mental stress
    Natalie Owen
    Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK
    Brain Behav Immun 17:286-95. 2003
    ..Post-stress recovery was delayed in women compared with men. The results suggest that moderate inflammation and immune activation may be processes through which lower SES increases disease risk...
  82. ncbi The interrelationship of maternal stress, endocrine factors and inflammation on gestational length
    Roberta J Ruiz
    Department of Family Nursing Care, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229, USA
    Obstet Gynecol Surv 58:415-28. 2003
    ..This review addresses the role of maternal stress on the regulation of maternal hormone and inflammatory responses and how aberrations in these systems may lead to preterm birth...
  83. ncbi Stress, stress response, and health
    Sandra Adams Motzer
    Department of Biobehavioral Nursing and Health Systems, University of Washington School of Nursing, 1959 NE Pacific Street, Box 357266, Seattle, WA 98195 7266, USA
    Nurs Clin North Am 39:1-17. 2004
    ..Further study is needed to clarify the influence of ovarian hormones on the stress and immune responses during the reproductive stages in women's lives, including menarche. pregnancy, and perimenopause...
  84. ncbi Life stress and cervical squamous intraepithelial lesions in women with human papillomavirus and human immunodeficiency virus
    Deidre Byrnes Pereira
    Department of Psychology, University of Miami, Coral Gables, Florida 32610 0165, USA
    Psychosom Med 65:427-34. 2003
    ....
  85. ncbi Cytokines and sleep: the first hundred years
    Mark R Opp
    Departments of Anesthesiology and Molecular and Integrative, Physiology and the Neuroscience Graduate Program, Ann Arbor, MI 48109-0615, USA
    Brain Behav Immun 18:295-7. 2004
  86. ncbi Neuroimmunomodulation in medical oncology: application of psychoneuroimmunology with subcutaneous low-dose IL-2 and the pineal hormone melatonin in patients with untreatable metastatic solid tumors
    Paolo Lissoni
    Division of Radiation Oncology, S Gerardo Hospital, Monza, Italy
    Anticancer Res 28:1377-81. 2008
    ....
  87. ncbi Neuroendocrine mechanisms of immune dysregulation: applications to allergy and asthma
    Gailen D Marshall
    Division of Allergy and Clinical Immunology, The University of Texas Medical School at Houston, Houston, Texas 77030 1501, USA
    Ann Allergy Asthma Immunol 93:S11-7. 2004
    ....
  88. ncbi Biobehavioral mechanisms of work-related upper extremity disorders: a new agenda for research and practice
    Michael Feuerstein
    Department of Medical and Clinical Psychology, Uniformed Services University of Health Services, Bethesda, Maryland 20814 4799, USA
    Am J Ind Med 41:293-7. 2002
    ..Despite this evidence, the biological plausibility of a relationship between exposure to various psychosocial and work organizational stressors and WRUEDs remains unclear..
  89. ncbi [The meaning of wholeness in medical philosophy]
    Klaus Michael Meyer-Abich
    Charitas Bischoff Treppe 9, 22587 Hamburg, Germany
    Forsch Komplementmed 14:240-6. 2007
    ..On the first one psychosomatic experiences tend to be confirmed by recent results of psychoneuroimmunology. On the second level health or pathogenicity of private or professional social environments tend to be ..
  90. ncbi Associations among central nervous, endocrine, and immune activities when positive emotions are elicited by looking at a favorite person
    Masahiro Matsunaga
    Department of Psychology, Graduate School of Environmental Studies, Nagoya University, Aichi, Japan
    Brain Behav Immun 22:408-17. 2008
    Recent studies on psychoneuroimmunology have indicated that positive psychological events are related to immune functions; however, limited information is available regarding associations among the central nervous, endocrine, and immune ..
  91. ncbi The effect of mirthful laughter on stress and natural killer cell activity
    Mary P Bennett
    Indiana State University School of Nursing, Terre Haute, Ind, USA
    Altern Ther Health Med 9:38-45. 2003
    ..b>Psychoneuroimmunology research suggests that, in addition to its established psychological benefits, humor may have ..
  92. ncbi Using complementary and alternative medicine curricular elements to foster medical student self-awareness
    Willam Elder
    Department of Family and Community Medicine, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0284, USA
    Acad Med 82:951-5. 2007
    ....
  93. ncbi Stress, neuropsychiatric disorders and immunological effects exerted by benzodiazepines
    V Covelli
    II Faculty of Medicine, University of Naples, Italy
    Immunopharmacol Immunotoxicol 20:199-209. 1998
    b>Psychoneuroimmunology is a growing scientific field which deals with the mutual interplay between nervous and immune systems...
  94. ncbi 50 years of hypnosis in medicine and clinical health psychology: a synthesis of cultural crosscurrents
    Mark B Weisberg
    Minnesota Head and Neck Pain Clinic, St Paul, MN 55114, USA
    Am J Clin Hypn 51:13-27. 2008
    ..by the rapid growth of technological medicine in the 1950's, the AIDS epidemic and development of psychoneuroimmunology, revolutionary developments in genetics and neuroimaging technology, and the progression from alternative ..
  95. ncbi Stress, depression, the immune system, and cancer
    Edna Maria Vissoci Reiche
    Department of Pathology, Clinical Analysis and Toxicology, Health Sciences Centre, State University of Londrina, Londrina, Parana, Brazil
    Lancet Oncol 5:617-25. 2004
    ..the psychological and physiological features of cancer risk and progression have been studied through psychoneuroimmunology. The persistent activation of the hypothalamic-pituitary-adrenal (HPA) axis in the chronic stress response ..
  96. ncbi Somatization: a psychoneuroimmune perspective
    Robert Dantzer
    Neurobiologie Integrative, CNRS INRA Université de Bordeaux 2, Institut Francois Magendie, 33077 Bordeaux Cedex, France
    Psychoneuroendocrinology 30:947-52. 2005
    ..Recent advances in psychoneuroimmunology offer new perspectives in this area...
  97. ncbi How faith heals: a theoretical model
    Jeff Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Explore (NY) 5:77-96. 2009
    ..of hope, learned optimism, positive illusions, and opening up or disclosure, and to theory and research on psychoneuroimmunology and placebos, demonstrates that contemporary psychology can accommodate a healing power of faith...
  98. ncbi ["Sickness behavior"--mechanisms of origin and significance]
    Dariusz Soszynski
    Katedra i Zakład Fizjologii, Akademii Medycznej im Ludwika Rydygiera, w Bydgoszczy
    Postepy Hig Med Dosw (Online) 58:74-82. 2004
    b>Psychoneuroimmunology, a combination of immunology and neurobiology, is a new field that has emerged over the past 20 years...
  99. ncbi Immunological research in clinical psychiatry: report on the consensus debate during the 7th Expert Meeting on Psychiatry and Immunology
    V Arolt
    Department of Psychiatry, University of Muenster, Albert Schweitzer Strasse 11, D 48129 Muenster, Germany
    Mol Psychiatry 7:822-6. 2002
    ..where a consensus symposium was held to consider the strengths and weaknesses of current research in psychoneuroimmunology. Following a general overview of the field, the following topics were discussed: (1) methodological ..
  100. ncbi Psychoneuroimmunological outcomes and quality of life
    M A Webber
    Department of Haematology, Constantiaberg Mediclinic Hospitals, P O Box 11219, Bloubergrant 7443, South Africa
    Transfus Apher Sci 42:157-61. 2010
    According to the American Psychological Association the field of psychoneuroimmunology comprises a rapidly expanding body of knowledge that strongly suggests a reciprocal interaction between mind (cognition) and body...
  101. ncbi Neuroimmunologic influences in neuropsychiatric and psychophysiologic disorders
    G Fricchione
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Acta Pharmacol Sin 22:577-87. 2001
    ..This may provide new strategies for pharmacologic anti inflammatory treatments. The monocyte /macrophage, which crosses the blood brain barrier is an essential candidate cell in the study of psychoneuroimmunology.

Research Grants69

  1. Preterm Birth: Psychoneuroimmunology in Hispanics
    ROBERTA RUIZ; Fiscal Year: 2005
    ..A clearer understanding of the interrelationships of the pathways leading to preterm birth and associated LBW is essential to determine and develop appropriate preventive strategies. ..
  2. Psychoneuroimmunology of T Cell Activation
    Steve Zalcman; Fiscal Year: 2004
    ..abstract_text> ..
  3. Psychoneuroimmunology: Preterm Birth in Hispanics
    ROBERTA RUIZ; Fiscal Year: 2009
    ..e. increasing the risk of preterm birth). Our understanding of the relation between acculturation and prematurity is vital in the process of implementing interventions to promote a healthy maternal and fetal outcome. ..
  4. Psychoneuroimmunology: Preterm Birth in Hispanics
    Roberta Jeanne Ruiz; Fiscal Year: 2010
    ..e. increasing the risk of preterm birth). Our understanding of the relation between acculturation and prematurity is vital in the process of implementing interventions to promote a healthy maternal and fetal outcome. ..
  5. Psychoneuroimmunology: Preterm Birth in Hispanics
    Roberta Jeanne Ruiz; Fiscal Year: 2010
    ..e. increasing the risk of preterm birth). Our understanding of the relation between acculturation and prematurity is vital in the process of implementing interventions to promote a healthy maternal and fetal outcome. ..
  6. Diet and Breast Density over Time in US Chinese Women
    Marilyn Tseng; Fiscal Year: 2009
    ..use a transdisciplinary approach, with expertise in breast cancer epidemiology, genetic epidemiology, and psychoneuroimmunology, to offer new insight into the effects of interactions between psychosocial and genetic factors on breast ..
  7. PNI and Decision Making in Women Diagnosed with DCIS
    LINDA JANUSEK; Fiscal Year: 2007
    ..Extensive evidence from the multidisciplinary field of psychoneuroimmunology (PNI) has demonstrated that emotional distress impairs immune function, including NK cell activity and ..
  8. Cognitive Behavioral Effects on Sleep, Pain, and Cytokines in Gynecologic Cancer
    Deidre B Pereira; Fiscal Year: 2010
    ..will be implemented by a multidisciplinary team with research/clinical experience in psycho-oncology, psychoneuroimmunology (PNI), behavioral sleep medicine, pain, reproductive immunology, and gynecologic oncology...
  9. Complicated Grief in Older Adults: Physiological Substrates of Emotion Regulation
    MARY FRANCES O CONNOR; Fiscal Year: 2007
    ..The Cousins Center for Psychoneuroimmunology at UCLA has both excellent resources (e.g. 3T imaging scanner) and excellent mentors (including Dr...
  10. The Rochester Center for Mind-Body Research
    Jan Moynihan; Fiscal Year: 2007
    ..on our considerable strengths in clinical science, aging research, developmental psychobiology and psychoneuroimmunology. We bring together scientists from multiple disciplines to create cross-disciplinary research teams that ..
  11. The Psychoneuroimmunology of Insomnia: Response to a Vaccine Challenge
    WILFRED PIGEON; Fiscal Year: 2009
    ..is to engage in a program of training and developing research that will allow the applicant to blend psychoneuroimmunology (PNI) and insomnia research, and to foster a program of investigation that seeks to delineate how two ..
  12. The Psychoneuroimmunology of Insomnia: Response to a Vaccine Challenge
    WILFRED PIGEON; Fiscal Year: 2007
    ..is to engage in a program of training and developing research that will allow the applicant to blend psychoneuroimmunology (PNI) and insomnia research, and to foster a program of investigation that seeks to delineate how two ..
  13. Effects of Energy Healers on Atherosclerosis
    Joan Fox; Fiscal Year: 2003
    ..The rapidly growing field of psychoneuroimmunology is providing insights into potential mechanisms by which emotional health could affect physical health...
  14. Accelerated Biologic Aging and Risk for Sepsis and Organ Failure Following Trauma
    ELIZABETH GROOMS NESMITH; Fiscal Year: 2010
    ..by an adapted version of the Vulnerable Populations Conceptual Framework which incorporates concepts from Psychoneuroimmunology, this project will examine bio-behavioral mechanisms associated with chronic stress and accelerated ..
  15. MBSR for Stress-Related Immune Dysregulation in Cancer
    LINDA JANUSEK; Fiscal Year: 2004
    ..Extensive evidence from the multi-disciplinary field of psychoneuroimmunology (PNI) has demonstrated that emotional distress impairs immune function...
  16. Psychosocial Influences on Systemic Lupus
    CAROL GRECO; Fiscal Year: 2007
    ..and strengthen her skills in cardiovascular behavioral medicine, psychophysiologic assessment, and psychoneuroimmunology. Mentors Susan Manzi, MD, MPH, Karen Matthews, Ph.D., and Andrew Baum, Ph.D...
  17. Mindfulness Based Stress Reduction for Psycho-Immune Dysregulation in Cancer
    HERBERT MATHEWS; Fiscal Year: 2009
    ..Interventions that stem the tide of negative emotions and their physiological sequelae are needed. Psychoneuroimmunology (PNI) has established that psychosocial distress impairs immune function...