Summary: Focusing on certain aspects of current experience to the exclusion of others. It is the act of heeding or taking notice or concentrating.

Top Publications

  1. ncbi Control of goal-directed and stimulus-driven attention in the brain
    Maurizio Corbetta
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Rev Neurosci 3:201-15. 2002
  2. pmc The human brain is intrinsically organized into dynamic, anticorrelated functional networks
    Michael D Fox
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:9673-8. 2005
  3. ncbi An integrative theory of prefrontal cortex function
    E K Miller
    Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Neurosci 24:167-202. 2001
  4. pmc A default mode of brain function
    M E Raichle
    Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:676-82. 2001
  5. ncbi The cognitive control of emotion
    Kevin N Ochsner
    Department of Psychology, Columbia University, Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10027, USA
    Trends Cogn Sci 9:242-9. 2005
  6. ncbi Effects of attention and emotion on face processing in the human brain: an event-related fMRI study
    P Vuilleumier
    Institute of Cognitive Neuroscience, University College London, England, London, United Kingdom
    Neuron 30:829-41. 2001
  7. ncbi Uncertainty, neuromodulation, and attention
    Angela J Yu
    Gatsby Computational Neuroscience Unit, London, United Kingdom
    Neuron 46:681-92. 2005
  8. pmc Wandering minds: the default network and stimulus-independent thought
    Malia F Mason
    Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA
    Science 315:393-5. 2007
  9. ncbi Alpha-band electroencephalographic activity over occipital cortex indexes visuospatial attention bias and predicts visual target detection
    Gregor Thut
    Center for Noninvasive Brain Stimulation, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 26:9494-502. 2006
  10. ncbi Distracted and confused?: selective attention under load
    Nilli Lavie
    Department of Psychology and Institute of Cognitive Neuroscience, University College, Gower Street, London WC1E 6BT, UK
    Trends Cogn Sci 9:75-82. 2005

Detail Information

Publications340 found, 100 shown here

  1. ncbi Control of goal-directed and stimulus-driven attention in the brain
    Maurizio Corbetta
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Rev Neurosci 3:201-15. 2002
    ..This ventral frontoparietal network works as a 'circuit breaker' for the dorsal system, directing attention to salient events...
  2. pmc The human brain is intrinsically organized into dynamic, anticorrelated functional networks
    Michael D Fox
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:9673-8. 2005
    During performance of attention-demanding cognitive tasks, certain regions of the brain routinely increase activity, whereas others routinely decrease activity...
  3. ncbi An integrative theory of prefrontal cortex function
    E K Miller
    Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Neurosci 24:167-202. 2001
    ..We review neurophysiological, neurobiological, neuroimaging, and computational studies that support this theory and discuss its implications as well as further issues to be addressed..
  4. pmc A default mode of brain function
    M E Raichle
    Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:676-82. 2001
    ..These decreases suggest the existence of an organized, baseline default mode of brain function that is suspended during specific goal-directed behaviors...
  5. ncbi The cognitive control of emotion
    Kevin N Ochsner
    Department of Psychology, Columbia University, Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10027, USA
    Trends Cogn Sci 9:242-9. 2005
    ..Such studies have examined (1) controlling attention to, and (2) cognitively changing the meaning of, emotionally evocative stimuli...
  6. ncbi Effects of attention and emotion on face processing in the human brain: an event-related fMRI study
    P Vuilleumier
    Institute of Cognitive Neuroscience, University College London, England, London, United Kingdom
    Neuron 30:829-41. 2001
    ..event-related fMRI to assess whether brain responses to fearful versus neutral faces are modulated by spatial attention. Subjects performed a demanding matching task for pairs of stimuli at prespecified locations, in the presence of ..
  7. ncbi Uncertainty, neuromodulation, and attention
    Angela J Yu
    Gatsby Computational Neuroscience Unit, London, United Kingdom
    Neuron 46:681-92. 2005
    ..Moreover, the model suggests a class of attentional cueing tasks that involve both neuromodulators and shows how their interactions may be part-antagonistic, part-synergistic...
  8. pmc Wandering minds: the default network and stimulus-independent thought
    Malia F Mason
    Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA
    Science 315:393-5. 2007
    ..In addition, individuals' reports of the tendency of their minds to wander were correlated with activity in this network...
  9. ncbi Alpha-band electroencephalographic activity over occipital cortex indexes visuospatial attention bias and predicts visual target detection
    Gregor Thut
    Center for Noninvasive Brain Stimulation, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 26:9494-502. 2006
    Covertly directing visual attention toward a spatial location in the absence of visual stimulation enhances future visual processing at the attended position...
  10. ncbi Distracted and confused?: selective attention under load
    Nilli Lavie
    Department of Psychology and Institute of Cognitive Neuroscience, University College, Gower Street, London WC1E 6BT, UK
    Trends Cogn Sci 9:75-82. 2005
    ..These findings provide a resolution to the long-standing early and late selection debate within a load theory of attention that accommodates behavioural and neuroimaging data within a framework that integrates attention research with ..
  11. pmc Top-down modulation: bridging selective attention and working memory
    Adam Gazzaley
    Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA
    Trends Cogn Sci 16:129-35. 2012
    Selective attention, the ability to focus our cognitive resources on information relevant to our goals, influences working memory (WM) performance. Indeed, attention and working memory are increasingly viewed as overlapping constructs...
  12. ncbi Computational modelling of visual attention
    L Itti
    Hedco Neuroscience Building, University of Southern California, 3641 Watt Way, Los Angeles, California 90089 2520, USA
    Nat Rev Neurosci 2:194-203. 2001
    Five important trends have emerged from recent work on computational models of focal visual attention that emphasize the bottom-up, image-based control of attentional deployment...
  13. ncbi Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study
    Yair Bar-Haim
    Adler Center for Reasearch in Child Development and Psychopathology, Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Psychol Bull 133:1-24. 2007
    ..Empirical and clinical implications as well as future directions for research are discussed...
  14. ncbi The magical number 4 in short-term memory: a reconsideration of mental storage capacity
    N Cowan
    Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA
    Behav Brain Sci 24:87-114; discussion 114-85. 2001
    ..Reasons why pure capacity estimates fall within a narrow range are discussed and a capacity limit for the focus of attention is proposed.
  15. doi Entrainment of neuronal oscillations as a mechanism of attentional selection
    Peter Lakatos
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Science 320:110-3. 2008
    Whereas gamma-band neuronal oscillations clearly appear integral to visual attention, the role of lower-frequency oscillations is still being debated...
  16. ncbi Joint action: bodies and minds moving together
    Natalie Sebanz
    Rutgers, The State University of New Jersey, Psychology Department, Smith Hall, 101 Warren Street, Newark, NJ 07102, USA
    Trends Cogn Sci 10:70-6. 2006
    ..In this article we outline how studies on joint attention, action observation, task sharing, action coordination and agency contribute to the understanding of the ..
  17. ncbi The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 163:362-80. 2002
    ..The developmental history and application of the 5-choice serial reaction time task (5CSRTT) for measuring effects of drugs and other manipulations on attentional performance (and stimulus control) in rats is reviewed...
  18. pmc Gaze cueing of attention: visual attention, social cognition, and individual differences
    Alexandra Frischen
    Macquarie Centre for Cognitive Science, Macquarie University, Sydney, NSW, Australia
    Psychol Bull 133:694-724. 2007
    During social interactions, people's eyes convey a wealth of information about their direction of attention and their emotional and mental states...
  19. ncbi Prestimulus oscillations predict visual perception performance between and within subjects
    Simon Hanslmayr
    Department of Experimental Psychology, Regensburg University, 93040 Regensburg, Germany
    Neuroimage 37:1465-73. 2007
    ..We conclude that alpha, beta and gamma oscillations indicate the attentional state of a subject and thus are able to predict perception performance on a single trial basis...
  20. ncbi Emotion drives attention: detecting the snake in the grass
    A Ohman
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Exp Psychol Gen 130:466-78. 2001
    ..Thus, evolutionary relevant threatening stimuli were effective in capturing attention, and this effect was further facilitated if the stimulus was emotionally provocative.
  21. doi Different states in visual working memory: when it guides attention and when it does not
    Christian N L Olivers
    Department of Cognitive Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    Trends Cogn Sci 15:327-34. 2011
    Recent studies have revealed a strong relationship between visual working memory and selective attention, such that attention is biased by what is currently on our mind...
  22. pmc Mechanisms of attentional biases towards threat in anxiety disorders: An integrative review
    Josh M Cisler
    Psychology Department, University of Arkansas, USA
    Clin Psychol Rev 30:203-16. 2010
    ..Facilitated attention, difficulty in disengagement, and attentional avoidance comprise the components of attentional bias...
  23. ncbi Contributions of the amygdala to emotion processing: from animal models to human behavior
    Elizabeth A Phelps
    Department of Psychology, New York University, 4 6 Washington Place, New York, New York 10003, USA
    Neuron 48:175-87. 2005
    ..amygdala in humans and other animals, including implicit emotional learning and memory, emotional modulation of memory, emotional influences on attention and perception, emotion and social behavior, and emotion inhibition and regulation.
  24. ncbi The activation of attentional networks
    Jin Fan
    Laboratory of Neuroimaging, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroimage 26:471-9. 2005
    Alerting, orienting, and executive control are widely thought to be relatively independent aspects of attention that are linked to separable brain regions...
  25. ncbi The emotional Stroop task and psychopathology
    J M Williams
    Department of Psychology, University of Wales, Bangor, Gwynedd
    Psychol Bull 120:3-24. 1996
    ..They address the causes and mechanisms underlying the phenomenon, focusing on J.D. Cohen, K. Dunbar, and J.L. McClelland's (1990) parallel distributed processing model...
  26. ncbi Load theory of selective attention and cognitive control
    Nilli Lavie
    Department of Psychology, University College London, London, United Kingdom
    J Exp Psychol Gen 133:339-54. 2004
    A load theory of attention in which distractor rejection depends on the level and type of load involved in current processing was tested...
  27. ncbi Dynamic causal modelling
    K J Friston
    The Wellcome Department of Imaging Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 19:1273-302. 2003
    ..psychophysiologic interactions). However, unlike previous approaches in neuroimaging, the causal model ascribes responses to designed deterministic inputs, as opposed to treating inputs as unknown and stochastic...
  28. ncbi The processing-speed theory of adult age differences in cognition
    T A Salthouse
    Georgia Institute of Technology, Atlanta 30332 0170, USA
    Psychol Rev 103:403-28. 1996
  29. ncbi The neural bases of momentary lapses in attention
    D H Weissman
    Center for Cognitive Neuroscience and Department of Psychiatry, Duke University, Durham, North Carolina 27708, USA
    Nat Neurosci 9:971-8. 2006
    Momentary lapses in attention frequently impair goal-directed behavior, sometimes with serious consequences. Nevertheless, we lack an integrated view of the brain mechanisms underlying such lapses...
  30. ncbi Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection
    Martin Sarter
    Department of Psychology, University of Michigan, 525 E University Ave, Ann Arbor, MI 48109 1109, USA
    Brain Res Brain Res Rev 48:98-111. 2005
    ..hypothesizes that the cortical cholinergic input system generally acts to optimize the processing of signals in attention-demanding contexts...
  31. pmc Attention, intention, and priority in the parietal lobe
    James W Bisley
    Department of Neurobiology and Jules Stein Eye Institute, David Geffen School of Medicine, and Department of Psychology and the Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Annu Rev Neurosci 33:1-21. 2010
    ..area that has been shown to play independent roles in target selection for saccades and the generation of visual attention. Based on results from a variety of tasks, we propose that LIP acts as a priority map in which objects are ..
  32. pmc High-frequency, long-range coupling between prefrontal and visual cortex during attention
    Georgia G Gregoriou
    McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 324:1207-10. 2009
    ..inputs from other structures? Using paired recordings in the frontal eye field (FEF) and area V4, we found that attention to a stimulus in their joint receptive field leads to enhanced oscillatory coupling between the two areas, ..
  33. ncbi Neurocognitive deficit in schizophrenia: a quantitative review of the evidence
    R W Heinrichs
    Department of Psychology, York University, Toronto, Ontario, Canada
    Neuropsychology 12:426-45. 1998
    ..and selective verbal memory, nonverbal memory, bilateral and unilateral motor performance, visual and auditory attention, general intelligence, spatial ability, executive function, language, and interhemispheric tactile-transfer test ..
  34. pmc Spontaneous EEG oscillations reveal periodic sampling of visual attention
    Niko A Busch
    Institute of Medical Psychology, Charite Universitatsmedizin, 10099 Berlin, Germany
    Proc Natl Acad Sci U S A 107:16048-53. 2010
    An important effect of sustained attention is the facilitation of perception...
  35. ncbi Valid conjunction inference with the minimum statistic
    Thomas Nichols
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Neuroimage 25:653-60. 2005
    ..This result holds even if the comparisons are not independent. We suggest that the revised test proposed here is the appropriate means for conjunction inference in neuroimaging...
  36. ncbi The mismatch negativity (MMN) in basic research of central auditory processing: a review
    R Naatanen
    Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, Helsinki, Finland
    Clin Neurophysiol 118:2544-90. 2007
    ..In addition, the MMN enables one to establish the brain processes underlying the initiation of attention switch to, conscious perception of, sound change in an unattended stimulus stream.
  37. ncbi A common network of functional areas for attention and eye movements
    M Corbetta
    Department of Neurology, McDonnell Center for Higher Brain Functions, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 21:761-73. 1998
    ..of brain activity were used to compare the functional anatomy of two tasks, one involving covert shifts of attention to peripheral visual stimuli, the other involving both attentional and saccadic shifts to the same stimuli...
  38. pmc Attention regulation and monitoring in meditation
    Antoine Lutz
    Waisman Laboratory for Brain Imaging and Behavior, Department of Psychology, University of Wisconsin, Madison, WI 53705, USA
    Trends Cogn Sci 12:163-9. 2008
    ..Among these various practices, there are two styles that are commonly studied. One style, focused attention meditation, entails the voluntary focusing of attention on a chosen object...
  39. pmc α-band oscillations, attention, and controlled access to stored information
    Wolfgang Klimesch
    Department of Physiological Psychology, University of Salzburg, A 5020 Salzburg, Austria
    Trends Cogn Sci 16:606-17. 2012
    ..oscillations have two roles (inhibition and timing) that are closely linked to two fundamental functions of attention (suppression and selection), which enable controlled knowledge access and semantic orientation (the ability to ..
  40. pmc Spatial neglect and attention networks
    Maurizio Corbetta
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Neurosci 34:569-99. 2011
    ..Core spatial deficits involve mechanisms for saliency coding, spatial attention, and short-term memory and occur in conjunction with nonspatial deficits that involve reorienting, target ..
  41. pmc Attention improves performance primarily by reducing interneuronal correlations
    Marlene R Cohen
    Howard Hughes Medical Institute and Harvard Medical School Department of Neurobiology, Boston, Massachusetts, USA
    Nat Neurosci 12:1594-600. 2009
    Visual attention can improve behavioral performance by allowing observers to focus on the important information in a complex scene. Attention also typically increases the firing rates of cortical sensory neurons...
  42. doi On the role of prestimulus alpha rhythms over occipito-parietal areas in visual input regulation: correlation or causation?
    Vincenzo Romei
    Centre for Cognitive Neuroimaging, Department of Psychology, University of Glasgow, Glasgow G12 8QB, UK
    J Neurosci 30:8692-7. 2010
    ..Posterior alpha power is influenced by visual spatial attention via top-down control from higher order attention areas such as the frontal eye field...
  43. pmc Processing of emotional distraction is both automatic and modulated by attention: evidence from an event-related fMRI investigation
    Andrea T Shafer
    University of Alberta, Canada
    J Cogn Neurosci 24:1233-52. 2012
    ..emotional stimuli have been thought to be automatically processed via a bottom-up automatic "capture of attention" mechanism...
  44. ncbi Attention and consciousness: two distinct brain processes
    Christof Koch
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Trends Cogn Sci 11:16-22. 2007
    The close relationship between attention and consciousness has led many scholars to conflate these processes...
  45. pmc Visual attention: the past 25 years
    Marisa Carrasco
    Psychology and Neural Science, New York University, NY, NY, United States
    Vision Res 51:1484-525. 2011
    This review focuses on covert attention and how it alters early vision...
  46. pmc The normalization model of attention
    John H Reynolds
    Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Neuron 61:168-85. 2009
    b>Attention has been found to have a wide variety of effects on the responses of neurons in visual cortex...
  47. ncbi Human gamma-frequency oscillations associated with attention and memory
    Ole Jensen
    F C Donders Centre for Cognitive Neuroimaging, Kapittelweg 29, 6525 EN Nijmegen, The Netherlands
    Trends Neurosci 30:317-24. 2007
    ..from recordings in animals and humans have suggested that gamma-frequency activity also has an important role in attention and both working and long-term memory...
  48. pmc Positive affect increases the breadth of attentional selection
    G Rowe
    Department of Psychology, University of Toronto, Toronto, ON, Canada M5S 3G3
    Proc Natl Acad Sci U S A 104:383-8. 2007
    ..was measured in two different cognitive domains: semantic search (remote associates task) and visual selective attention (Eriksen flanker task)...
  49. pmc Cortical state and attention
    Kenneth D Harris
    Department of Bioengineering, Imperial College, London SW7 2AZ, UK kenneth harris imperial ac uk
    Nat Rev Neurosci 12:509-23. 2011
    ..information processing has been investigated: the study of state-dependent cortical processing in rodents and attention in the primate visual system...
  50. ncbi Anticipatory biasing of visuospatial attention indexed by retinotopically specific alpha-band electroencephalography increases over occipital cortex
    M S Worden
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 20:RC63. 2000
    ..cortex contralateral to the direction of the to-be-ignored location (ipsilateral to the cued direction of attention) before onset of the to-be-attended stimulus...
  51. pmc Attention alters appearance
    Marisa Carrasco
    Department of Psychology, New York University, 6 Washington Place, New York, New York 10003, USA
    Nat Neurosci 7:308-13. 2004
    Does attention alter appearance? This critical issue, debated for over a century, remains unsettled...
  52. pmc Dynamic shifts of limited working memory resources in human vision
    Paul M Bays
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
    Science 321:851-4. 2008
    ..This resource can be shifted flexibly between objects, with allocation biased by selective attention and toward targets of upcoming eye movements...
  53. pmc Decoding the visual and subjective contents of the human brain
    Yukiyasu Kamitani
    ATR Computational Neuroscience Laboratories, 2 2 2 Hikaridai, Keihanna Science City, Kyoto 619 0288, Japan
    Nat Neurosci 8:679-85. 2005
    ..Moreover, when subjects had to attend to one of two overlapping orthogonal gratings, feature-based attention strongly biased ensemble activity toward the attended orientation...
  54. ncbi Action video game modifies visual selective attention
    C Shawn Green
    Department of Brain and Cognitive Sciences, Center for Visual Science, University of Rochester, Rochester, New York 14627, USA
    Nature 423:534-7. 2003
    ..Four experiments establish changes in different aspects of visual attention in habitual video-game players as compared with non-video-game players...
  55. ncbi Increased activity in human visual cortex during directed attention in the absence of visual stimulation
    S Kastner
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuron 22:751-61. 1999
    When subjects direct attention to a particular location in a visual scene, responses in the visual cortex to stimuli presented at that location are enhanced, and the suppressive influences of nearby distractors are reduced...
  56. ncbi The proactive brain: using analogies and associations to generate predictions
    Moshe Bar
    Martinos Center for Biomedical Imaging at MGH, Harvard Medical School, 149 Thirteenth Street, Charlestown, MA 02129, USA
    Trends Cogn Sci 11:280-9. 2007
    ..This cognitive neuroscience framework can help explain a variety of phenomena, ranging from recognition to first impressions, and from the brain's 'default mode' to a host of mental disorders...
  57. pmc Investigation of mindfulness meditation practitioners with voxel-based morphometry
    Britta K Hölzel
    Bender Institute of Neuroimaging, Justus Liebig University, 35394 Giessen, Germany
    Soc Cogn Affect Neurosci 3:55-61. 2008
    ..Results suggest that meditation practice is associated with structural differences in regions that are typically activated during meditation and in regions that are relevant for the task of meditation...
  58. ncbi Mechanisms of visual attention in the human cortex
    S Kastner
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 23:315-41. 2000
    ..cortex can be biased by both bottom-up sensory-driven mechanisms and top-down influences, such as selective attention. Functional brain imaging studies reveal that, both in the absence and in the presence of visual stimulation, ..
  59. ncbi Anxiety and cognitive performance: attentional control theory
    Michael W Eysenck
    Department of Psychology, Royal Holloway University of London, London, United Kingdom
    Emotion 7:336-53. 2007
    ..In addition to decreasing attentional control, anxiety increases attention to threat-related stimuli...
  60. pmc The reorienting system of the human brain: from environment to theory of mind
    Maurizio Corbetta
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 58:306-24. 2008
    ..At rest, each network is distinct and internally correlated, but when attention is focused, the ventral network is suppressed to prevent reorienting to distracting events...
  61. ncbi The frontoparietal attention network of the human brain: action, saliency, and a priority map of the environment
    Radek Ptak
    Division of Neurorehabilitation, Geneva University Hospital, University of Geneva, Switzerland
    Neuroscientist 18:502-15. 2012
    ..frontal and parietal lobes forms a network that is crucially involved in the selection of sensory contents by attention. This network comprehends cortex along the intraparietal sulcus, the inferior parietal lobe, and dorsal premotor ..
  62. ncbi Dynamic brain sources of visual evoked responses
    S Makeig
    Computational Neurobiology Laboratory and, The Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, San Diego, CA 92037, USA
    Science 295:690-4. 2002
    ..In a human visual selective attention task, we show that nontarget event-related potentials were mainly generated by partial stimulus-induced phase ..
  63. ncbi The role of the right temporoparietal junction in social interaction: how low-level computational processes contribute to meta-cognition
    Jean Decety
    Department of Psychology, and Center for Cognitive and Social Neuroscience, The University of Chicago, Chicago, IL 60637, USA
    Neuroscientist 13:580-93. 2007
    ..engaged in lower-level (bottom-up) computational processes associated with the sense of agency and reorienting attention to salient stimuli...
  64. ncbi Age effects on gray matter volume and attentional performance in Zen meditation
    Giuseppe Pagnoni
    Department of Psychiatry and Behavioral Sciences, Emory University, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
    Neurobiol Aging 28:1623-7. 2007
    ..Voxel-based morphometry for MRI anatomical brain images and a computerized sustained attention task were employed in 13 regular practitioners of Zen meditation and 13 matched controls...
  65. ncbi Saccade target selection and object recognition: evidence for a common attentional mechanism
    H Deubel
    Max Planck Institut für Psychologische Forschung, Munchen, Germany
    Vision Res 36:1827-37. 1996
    The spatial interaction of visual attention and saccadic eye movements was investigated in a dual-task paradigm that required a target-directed saccade in combination with a letter discrimination task...
  66. ncbi To what extent are emotional visual stimuli processed without attention and awareness?
    Luiz Pessoa
    Department of Psychology, Brown University, 89 Waterman Street, Providence, RI 02912, USA
    Curr Opin Neurobiol 15:188-96. 2005
    ..e. conditions in which the focus of attention was diverted away from the stimuli due to task instructions), during visual masking and during binocular ..
  67. pmc Event-related brain potentials in the study of visual selective attention
    S A Hillyard
    Department of Neurosciences, 0608, University of California at San Diego, La Jolla, CA 92093 0608, USA
    Proc Natl Acad Sci U S A 95:781-7. 1998
    ..from blood-flow neuroimaging studies enable improved localization of cortical activity during visual selective attention. ERP modulations during spatial attention point toward a mechanism of gain control over information flow in ..
  68. ncbi Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD
    R A Barkley
    Department of Psychiatry, University of Massachusetts Medical Center, Worcester 01655, USA
    Psychol Bull 121:65-94. 1997
    b>Attention deficit hyperactivity disorder (ADHD) comprises a deficit in behavioral inhibition...
  69. ncbi Storage and executive processes in the frontal lobes
    E E Smith
    Department of Psychology, Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Science 283:1657-61. 1999
    ..Two of the fundamental executive processes are selective attention and task management. Both processes activate the anterior cingulate and dorsolateral prefrontal cortex.
  70. pmc Spatial attention decorrelates intrinsic activity fluctuations in macaque area V4
    Jude F Mitchell
    Systems Neurobiology Lab, The Salk Institute, La Jolla, CA 92037 1099, USA
    Neuron 63:879-88. 2009
    b>Attention typically amplifies neuronal responses evoked by task-relevant stimuli while attenuating responses to task-irrelevant distracters...
  71. ncbi Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism
    Ami Klin
    Yale Child Study Center, Yale University, 230 S Frontage Rd, New Haven, CT 06520, USA
    Arch Gen Psychiatry 59:809-16. 2002
    ..Enhanced ecological validity was intended to maximize between-group effect sizes and assess the predictive utility of experimental variables relative to outcome measures of social competence...
  72. pmc Emotion facilitates perception and potentiates the perceptual benefits of attention
    Elizabeth A Phelps
    Department of Psychology and Center for Neural Science, New York University, NY 10003, USA
    Psychol Sci 17:292-9. 2006
    Does emotion affect how people see? We investigated the effects of emotion and attention, as well as their conjoint effect, on contrast sensitivity, a dimension of early vision...
  73. pmc Neural correlates of attentional expertise in long-term meditation practitioners
    J A Brefczynski-Lewis
    W M Keck Laboratory for Functional Brain Imaging and Behavior, Medical College of Wisconsin, University of Wisconsin, Madison, WI 53226, USA
    Proc Natl Acad Sci U S A 104:11483-8. 2007
    ..One of the most basic forms of meditation is concentration meditation, in which sustained attention is focused on an object such as a small visual stimulus or the breath...
  74. ncbi Neurocognitive mechanisms of anxiety: an integrative account
    Sonia J Bishop
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Trends Cogn Sci 11:307-16. 2007
    ..Recent neuroimaging studies of conditioned fear, attention to threat and interpretation of emotionally ambiguous stimuli indicate common amygdala-prefrontal circuitry ..
  75. pmc High gamma power is phase-locked to theta oscillations in human neocortex
    R T Canolty
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Science 313:1626-8. 2006
    ..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...
  76. ncbi Age-related changes in the time course of vigilant attention during 40 hours without sleep in men
    Martin Adam
    Institute of Pharmacology and Toxicology and Center for Integrative Human Physiology CIHP, University of Zurich, Switzerland
    Sleep 29:55-7. 2006
    To examine whether vigilant attention and sleepiness develop differently during prolonged wakefulness in young and older men.
  77. pmc Neural processing of emotional faces requires attention
    L Pessoa
    Laboratory of Brain and Cognition, National Institute of Mental Health, Building 10, Room 4C104, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:11458-63. 2002
    b>Attention gates the processing of stimuli relatively early in visual cortex. Yet, existing data suggest that emotional stimuli activate brain regions automatically, largely immune from attentional control...
  78. doi The locus coeruleus and noradrenergic modulation of cognition
    Susan J Sara
    CNRS UMR 7152, College de France, Paris 75005, France
    Nat Rev Neurosci 10:211-23. 2009
    Mood, attention and motivation co-vary with activity in the neuromodulatory systems of the brain to influence behaviour...
  79. ncbi Microsaccades uncover the orientation of covert attention
    Ralf Engbert
    Department of Psychology, University of Potsdam, P O Box 601553, 14415, Potsdam, Germany
    Vision Res 43:1035-45. 2003
    ..Here we investigate the modulation of microsaccades by shifts of covert attention in a classical spatial cueing paradigm...
  80. ncbi Reward expectation, orientation of attention and locus coeruleus-medial frontal cortex interplay during learning
    Sebastien Bouret
    Neuromodulation et Processus Mnésiques, CNRS UMR 7102, Universite Pierre and Marie Curie, 9 Quai St Bernard, 75005 Paris, France
    Eur J Neurosci 20:791-802. 2004
    Regulation of attention and promotion of behavioural flexibility are functions attributed to both the noradrenergic nucleus locus coeruleus (LC) and the prefrontal cortex (PFC)...
  81. pmc Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems
    Michael D Fox
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:10046-51. 2006
    On the basis of task-related imaging studies in normal human subjects, it has been suggested that two attention systems exist in the human brain: a bilateral dorsal attention system involved in top-down orienting of attention and a right-..
  82. ncbi Affective influences on the attentional dynamics supporting awareness
    Adam K Anderson
    Department of Psychology, University of Toronto, ON, Canada
    J Exp Psychol Gen 134:258-81. 2005
    ..These results suggest that arousal is associated with decreased attentional prerequisites for awareness, enabling emotional significance to shape perceptual experience...
  83. ncbi Evidence from functional magnetic resonance imaging of crossmodal binding in the human heteromodal cortex
    G A Calvert
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford, UK
    Curr Biol 10:649-57. 2000
    ..Although spatially concordant multisensory inputs can produce a dramatic, often multiplicative, increase in cellular activity, spatially disparate cues tend to induce a profound response depression...
  84. pmc Electroencephalographic signatures of attentional and cognitive default modes in spontaneous brain activity fluctuations at rest
    H Laufs
    Cognitive Neurology Unit, Department of Neurology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 100:11053-8. 2003
  85. ncbi Contextual cueing: implicit learning and memory of visual context guides spatial attention
    M M Chun
    Department of Psychology, Yale University, New Haven, CT 06520 8205, USA
    Cogn Psychol 36:28-71. 1998
    ..This study demonstrates that a robust memory for visual context exists to guide spatial attention. Global context was operationalized as the spatial layout of objects in visual search displays...
  86. ncbi Modulation of oscillatory neuronal synchronization by selective visual attention
    P Fries
    Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49, Room 1B80, 9000 Rockville Pike, Bethesda, MD 20892 4415, USA
    Science 291:1560-3. 2001
    In crowded visual scenes, attention is needed to select relevant stimuli. To study the underlying mechanisms, we recorded neurons in cortical area V4 while macaque monkeys attended to behaviorally relevant stimuli and ignored distracters...
  87. pmc Frontoparietal cortex controls spatial attention through modulation of anticipatory alpha rhythms
    Paolo Capotosto
    Dipartimento di Scienze Cliniche e Bioimmagini and Istituto di Tecnologie Avanzate Biomediche Università G D Annunzio, 66013 Chieti, Italy
    J Neurosci 29:5863-72. 2009
    ..sulcus (IPS) and frontal eye field (FEF), has been hypothesized to control the allocation of spatial attention to environmental stimuli...
  88. ncbi Functional anatomy of the attentional modulation of time estimation
    Jennifer T Coull
    Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Science 303:1506-8. 2004
    b>Attention modulates our subjective perception of time. The less we attend to an event's duration, the shorter it seems to last...
  89. ncbi Mechanisms of selective inhibition in visual spatial attention are indexed by alpha-band EEG synchronization
    Tonia A Rihs
    Functional Brain Mapping Laboratory, Department of Neurology, University Hospital Geneva, 24, Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Eur J Neurosci 25:603-10. 2007
    Electroencephalographic studies in humans have demonstrated that orienting of visual attention induces a decrease in oscillatory alpha-band activity (alpha-desynchronization) over cortical areas tuned to the attended visual space...
  90. doi Neural dissociation between visual awareness and spatial attention
    Valentin Wyart
    Universite Pierre et Marie Curie Paris 6, 75005 Paris, France
    J Neurosci 28:2667-79. 2008
    ..where we attend to? Psychologists have long stressed the tight relationship between visual awareness and spatial attention at the behavioral level...
  91. pmc The role of executive function and attention in gait
    Galit Yogev-Seligmann
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mov Disord 23:329-42; quiz 472. 2008
    ..Increasing evidence, however, links alterations in executive function and attention to gait disturbances...
  92. pmc α oscillations related to anticipatory attention follow temporal expectations
    Gustavo Rohenkohl
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    J Neurosci 31:14076-84. 2011
    ..alpha band, has been implicated in regulating excitability in visual areas as a function of anticipatory spatial attention. Here we asked whether temporal expectations derived from regular, rhythmic events can modulate ongoing ..
  93. ncbi Attention and the control of posture and gait: a review of an emerging area of research
    Marjorie Woollacott
    Department of Exercise and Movement Science, University of Oregon, Eugene, OR 97403, USA
    Gait Posture 16:1-14. 2002
    Research on the relationship between attention and the control of posture and gait is a new and expanding area with studies on young adults revealing the role of cognitive factors in the control of balance during standing and walking...
  94. doi Training and plasticity of working memory
    Torkel Klingberg
    Department of Neuroscience, Karolinska Institute, Retzius vag 8, 171 77 Stockholm, Sweden
    Trends Cogn Sci 14:317-24. 2010
    ..The observed training effects suggest that WM training could be used as a remediating intervention for individuals for whom low WM capacity is a limiting factor for academic performance or in everyday life...
  95. pmc Natural selective attention: orienting and emotion
    Margaret M Bradley
    Center for the Study of Emotion and Attention, University of Florida, Gainesville, Florida 32611, USA
    Psychophysiology 46:1-11. 2009
    The foundations of orienting and attention are hypothesized to stem from activation of defensive and appetitive motivational systems that evolved to protect and sustain the life of the individual...
  96. doi Causal interactions in attention networks predict behavioral performance
    Xiaotong Wen
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    J Neurosci 32:1284-92. 2012
    Lesion and functional brain imaging studies have suggested that there are two anatomically nonoverlapping attention networks...
  97. pmc The role of the right inferior frontal gyrus: inhibition and attentional control
    Adam Hampshire
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
    Neuroimage 50:1313-9. 2010
    ..Our results reveal that the RIFG is recruited when important cues are detected, regardless of whether that detection is followed by the inhibition of a motor response, the generation of a motor response, or no external response at all...
  98. ncbi The role of neuronal synchronization in selective attention
    Thilo Womelsdorf
    FC Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Kapittelweg 29, 6525 EN Nijmegen, The Netherlands
    Curr Opin Neurobiol 17:154-60. 2007
    b>Attention selectively enhances the influence of neuronal responses conveying information about relevant sensory attributes...
  99. ncbi Selective attention and emotional vulnerability: assessing the causal basis of their association through the experimental manipulation of attentional bias
    Colin MacLeod
    Department of Psychology, University of Western Australia, Nedlands, Perth
    J Abnorm Psychol 111:107-23. 2002
  100. ncbi The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: an individual-differences perspective
    Michael J Kane
    Department of Psychology, University of North Carolina, Greensboro, North Carolina 27402 6164, USA
    Psychon Bull Rev 9:637-71. 2002
    We provide an "executive-attention" framework for organizing the cognitive neuroscience research on the constructs of working-memory capacity (WMC), general fluid intelligence, and prefrontal cortex (PFC) function...
  101. pmc Attention bias modification treatment: a meta-analysis toward the establishment of novel treatment for anxiety
    Yuko Hakamata
    Division of Adult Mental Health, National Institute of Mental Health, Tokyo, Japan
    Biol Psychiatry 68:982-90. 2010
    b>Attention Bias Modification Treatment (ABMT) is a newly emerging, promising treatment for anxiety disorders...

Research Grants79

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    ..While these mechanisms have been explored in essential hypertension, they have received little attention in renovascular disease...
  3. Genome-wide recombination as a risk factor for nondisjunction
    NATASHA D HOLLIS; Fiscal Year: 2010
    ..The research plan is well written and attention has been paid to potential risks and confidentiality issues...
  4. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..In recent years, attention has turned towards the possibility that many chronic disorders, especially those involving autoimmune response, ..
  5. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..Although small ubiquitin-like modifier (SUMO) is a new member of this family, it has attracted a great deal of attention recently because of its novel and distinct functions...
  6. Effects of Testosterone and Genetic Factors on Psychological and Motor Function i
    NICOLE RENEE TARTAGLIA; Fiscal Year: 2013
    ..Our preliminary studies suggest that testosterone therapy started in early adolescence improves attention and self-report of personal adjustment, and does not lead to increased negative behaviors, and that individuals ..
    Gary Cecchini; Fiscal Year: 2013
    ..Reversible acetylation of lysine residues is one such modification that is receiving increasing attention. Metabolic proteins and large protein complexes, such as found in the mitochondrion, are particularly prone to ..
  8. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..of CBLB502's effect on protection and healing of small intestine in irradiated mice with particular attention on the role of bone marrow-derived cells...
  9. Targeting superbugs: discovery and development of new broad-spectrum lipopeptides
    Jian Li; Fiscal Year: 2013
    ..IDSA 'hit list'of the six top-priority dangerous microorganisms "ESKAPE" that require the most urgent attention to discover new antibiotics. Sadly, no novel antibiotics against MDR P. aeruginosa, A. baumannii and K...
  10. Systemic Inflammation and Central Nervous System Dysfunction
    Laura L Dugan; Fiscal Year: 2013
    ..and that Nox2, in turn, results in persistent deficits in inhibitory neural circuits required for learning, attention, and memory encoding...
  11. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE Research relevant to women's health is an area of D.V.A. attention. In order to effectively treat disorders associated with over 1...
  12. Arcuate nucleus glutamatergic neurons modulate energy homeostasis
    Anthony N van den Pol; Fiscal Year: 2013
    ..But in the hypothalamus, relatively little attention has been given to glutamate neurons, despite the fact that in the presence of glutamate receptor antagonists ..
  13. Adenosine and the Basal Forebrain in the Control of Behavioral State
    Robert E Strecker; Fiscal Year: 2012
    ..and vigilance performance? (using sleep recordings, sleep latency tests, and operant tests of sustained attention). CSR is predicted to produce sleepiness and cognitive impairments in rats (like in humans). Aim 2...
  14. A quantitative proteomics approach to understand viral immune evasion strategies
    Michele E Hardy; Fiscal Year: 2010
    Research into mechanisms utilized by viruses to evade cellular antiviral responses is receiving increased attention. These pathways and the key players, both viral and host, have garnered such focus because of the potential to develop ..
  15. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..LCNN constitute a critical component of the circuitry that is necessary for the processes of learning, memory, attention, sleep, arousal, anxiety, and responses to stress...
  16. Role of Peroxidasin in Glomerular Matrix Homeostasis
    Gautam Bhave; Fiscal Year: 2013
    ..Superoxide and its product, hydrogen peroxide (H2O2), are ROS that have garnered greatest attention in DN...
  17. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010 copy number variation (CNV): "Microscopic deletions and replications of the genome have attracted increasing attention for their potential role in many complex human diseases...
  18. Regulation of LPS-mediated HMGB1 Release by Poly (ADP-ribose) Polymerase-1
    RAJESH K ANEJA; Fiscal Year: 2013
    ..While much attention has been focused on the function of extracellular HMGB1, the mechanisms of HMGB1 release in sepsis have received ..
  19. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..Recently, special attention has focused on the role of phosphatidylinositol 3-kinase (PI3K) signaling pathways as mediator of leptin effects ..
  20. Use of Interactive Gaming for Enhanced Function after Spinal Cord Injury
    BEATRICE JENNY KIRATLI; Fiscal Year: 2011
    ..While interactive video gaming has gained attention in the lay-press and is being used as a rehabilitation approach in some clinical settings with a variety of ..
  21. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..We will focus our attention on two of the first described mutant NFL proteins, P8R NFL and Q333P NFL that we have characterized in the most ..
  22. Mechanisms of Bone Loss from Administration of the Second-Generation Antipsychoti
    KATHERINE JEAN MOTYL; Fiscal Year: 2013
    ..antipsychotics (SGAs) are commonly administered to children and adolescents for major psychiatric disorders, attention deficit disorder, and irritability associated with autism...
  23. The Role of Astrocytes in Cortical Interneuron Development
    KAREN MULLER SMITH; Fiscal Year: 2013
    ..Dr. Smith obtained her Ph.D. in genetics by performing candidate gene analysis of dopaminergic system genes in Attention Deficit Hyperactivity Disorder (ADHD)...
  24. Role of the neurogenic inflammatory pathway in the genital tract immune response
    Roger G Rank; Fiscal Year: 2010 inflammatory response at mucosal sites;however, a pathway mediated by neuropeptides has received little attention but may be equally as important in the induction of the inflammatory response by bacteria...
  25. Cell stress, development, and stimulant-induced behavior: Regulation by GSK3
    Marjelo A Mines; Fiscal Year: 2012
    ..has recently been a rapid increase in the prevalence of psychiatric diseases in young persons, particularly in attention-deficit/hyperactivity disorder (ADHD)...
  26. Folate Status, Genomic Uracil, and the Balance of Base Excision Repair Activity
    Michael D Wyatt; Fiscal Year: 2011
    ..provided by applicant): Dietary folic acid is an important nutrient for human health and has received much attention as a means of preventing cancer...
  27. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Lymphatic diseases have received insufficient attention in the past, such that progress in treating lymphatic disease has been slowed...
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2012
    ..To date, little attention has been given to the long-term impact of this reproductive experience on the female's physiology and ..
  29. PS11-003 Minority AIDS Research Initiative
    ..1) a targeted HIV/STI risk reduction intervention to reduce their risk of HIV and other STIs;or 2) an attention control condition on general health promotion to reduce their risk of adverse health conditions including cancer,..
  30. Dopamine's Role in the Rapid Estradiol Enhancement of Excitatory Synapses
    ..leader in the field of dopamine mediated alterations in hippocampal circuit and functional output, to focus my attention on dopamine dependent alterations in hippocampal circuit function...
  31. Effectivenss of a New Non-Invasive Erectile Support System in Aging Populations
    S ALEXANDER WEINSTOCK; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The fact that so much National attention is being placed on the solvency of the Social Security Administration reflects the fact that during the next ..
  32. Maternal Autoantibodies: Pathogenesis of Neonatal Lupus
    JILL PAMELA BUYON; Fiscal Year: 2013
    ..relative oxygen insult during pregnancy, and the need to explain CHB- discordance in monozygotic twins, directed attention to hypoxia as an amplification factor on the distal fibrosing component...
  33. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..Despite its significance this subject has received little attention from basic scientists...
  34. Salivary-based Bone-loss Marker Detection Platform for Point-of-Care Screening
    MANAL BESHAY; Fiscal Year: 2012
    ..Bone turnover markers can be assayed from blood or urine, however, recent attention has focused on salivary diagnostics because of their convenient and non-invasive nature of sampling...
  35. Improving Patient Safety: Context and Nurses'Work Processes for Pressure Ulcers
    Lynn M Soban; Fiscal Year: 2013
    ..adverse events and promoting patient safety in the hospital environment, yet have received comparatively little attention from patient safety researchers...
  36. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2012
    ..Dr. Buxton possesses a rare combination of medical knowledge, attention to detail, and vision...
  37. Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy an
    Heather R Burkin; Fiscal Year: 2013
    ..Dr. Buxton posesses a rare combination of medical knowledge, attention to detail, and vision...
  38. Controlled delivery of polypeptide hormone calcitonin
    Jagdish Singh; Fiscal Year: 2013
    ..The combined lifetime risk for hip, forearm, and vertebral fractures coming to clinical attention is ~40%, which is equal to the risk for cardiovascular disease...
  39. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..Disorders such as alcohol and other substance abuse disorders, unipolar depression, bipolar disorder and attention-deficit/hyperactivity disorder (ADHD) are amongst the most significant causes of morbidity and mortality in the ..
  40. Fall risk assessment and prevention in elderly with diabetes using wearable techn
    Bor Rong Chen; Fiscal Year: 2012
    ..This is an often neglected problem, and has received little attention regarding development of and testing of innovative strategies to improve balance and postural stability in this ..
  41. Oxidative Stress in Chronic Kidney Disease
    Talat Alp Ikizler; Fiscal Year: 2012
    ..factors are root causes of CKD development, progression, and associated complications, yet have received scant attention in translational research...
  42. Pathogenesis of Postoperative Cognitive Dysfunction
    Zhongcong Xie; Fiscal Year: 2013
    ..gene mutation- or aging-induced elevation of A[unreadable] levels, leading to impairment of learning/memory and attention/executive function...
    Bruce S McEwen; Fiscal Year: 2013
    ..on behavior, morphology and gene expression in hippocampus and prefrontal cortex? Our work has had major impact on the field of biological psychiatry by directing attention to structural changes in the brain as a result of stress.
  44. Genomic Enhancers at 8q24 and Prostate Cancer
    Gerhard A Coetzee; Fiscal Year: 2013
    ..1). Special attention will be directed towards already-identified, TCF7L2-, FoxA1- and androgen receptor-mediated risk mechanisms...
  45. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2013
    ..for preventing autoimmune diseases, decreasing inflammation and relieving joint pain are receiving increasing attention in the medical literature and the popular press...
  46. Fic-mediated Adenylylation
    CAROLYN ANN WORBY; Fiscal Year: 2013
    ..We focused our attention on IbpA since convalescent serum from symptomatic animals infected with H...
  47. Astrocytic Ca2+ Signaling in the Ischemic Penumbra
    Maiken Nedergaard; Fiscal Year: 2011
    ..The fate of astrocytes in the penumbra has received little attention, in part, because the activity of these non-excitable cells only can be analyzed by Ca2+ imaging technique...
  48. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011 estradiol, and thereby negatively impacts central physiological processes such as cognition, learning, and attention, and leads to perturbation of the circadian sleep-wake cycle...
  49. The Role of the Terminal Complement Pathway in ALS
    Scott R Barnum; Fiscal Year: 2013
    ..Neuroinflammation has received attention as a mechanism that participates in motor neuron loss in ALS, due in large part to the recognition of immune-..
  50. Histone Methylation: a role in excessive ethanol intake and self-administration
    Jennifer A Rinker; Fiscal Year: 2012
    ..focused on the role of histone acetylation and phosphorylation, while histone methylation has received far less attention. Histone acetylation has been implicated in the regulation of acute responses to ethanol, development of ..
    Steven G Clarke; Fiscal Year: 2013
    ..We will pay special attention to the human PRMT7 protein that has been implicated in tumor formation and stem cell survival...
  52. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..Much attention has understandably been paid to the possible long-term complications of radiation therapy to the brain and spine ..
  53. ATM Controls Genomic Stability in Pluripotent Stem Cells
    JASON MARK BECKTA; Fiscal Year: 2013
    ..Thus, we turned our attention to the decatenation checkpoint in order to elucidate ATM's role in PSCs...
    Zbigniew Darzynkiewicz; Fiscal Year: 2013
    ..Particular attention will be given to explore whether DNA damage occurs under conditions in which these probes are used to isolate ..
  55. Anxiety development in 5-HT1A autoreceptor knockout mice, interaction with stress
    Rene Hen; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Recently attention has been focused on how genetic variation interacts with the environment and development...
  56. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..knocking-down detrimental genes in macrophages, or using the macrophage as a delivery mechanism is gaining attention in the gene therapy field...
  57. Evaluation of novel FoxM1 inhibitors against liver cancer
    Andrei L Gartel; Fiscal Year: 2012
    ..One particular gene that has gained attention in recent years due to its importance in a number of cancers including HCC is Forkhead Box M1 (FoxM1)...
  58. Downregulation of Rod Metabolism in Retinopathy of Prematurity
    JAMES DANIEL AKULA; Fiscal Year: 2010
    ..of the vasculopathy has been the focus of much good work, but the insult to the neural retina has received less attention. Recent discoveries indicate that oxidative stress in the rod photoreceptors plays a causal role in ROP...
  59. Enterovirus RNA Translation and Replication
    David J Barton; Fiscal Year: 2013 the proposed investigation, will have significant impact on our understanding of molecular evolution, drawing attention to the common features and mechanisms of a viral RNA-dependent RNA polymerase and eukaryotic telomerase reverse-..
  60. Carbohydrate-based Antiinfective Agents
    Chi Huey Wong; Fiscal Year: 2013
    ..A strategy for a carbohydrate-modified HA protein vaccine is presented, with attention directed toward maximizing cross-reactive immunity.
  61. Best Management of Sigmoid Volvulus: a Prospective Randomized Trial
    JONATHAN CHARLES SAMUEL; Fiscal Year: 2013
    ..disease process is in part because it is predominately a disease of developing countries and has not received attention from skilled investigators and funding agencies...
  62. Dopamine Transporter Structure and Function
    Christopher K Surratt; Fiscal Year: 2010
    ..Rational, brain receptor protein-guided design of novel antidepressants, attention deficit therapeutics and other CNS-acting agents is also an unfulfilled goal of the dopamine transporter (DAT) ..
  63. Regulation of HIV-1 by Rad51 in CNS cells
    Kamel Khalili; Fiscal Year: 2013
    ..Recently, much attention has been focused on the impact of HIV-1 infection on host cell homeostasis, more specifically the interaction of ..
  64. Betahistine: Novel Therapeutic in Attention Deficit Hyperactivity Disorder
    CHARLES PIERCE; Fiscal Year: 2009 applicant): Satiety Solutions, is developing a novel histamine agonist, betahistine, as a treatment for attention-deficit, hyperactivity disorder (ADHD)...
    Michael T Carlin; Fiscal Year: 2011
    ..For many individuals, these methods have proven very successful. For some individuals, however, directing attention to task-relevant features of stimuli has proven difficult or impossible using these methods...
  66. Assessing space and feature based attention with fMRI and multivoxel pattern anal
    John Serences; Fiscal Year: 2010
    ..Thus, population coding schemes are necessary to provide a reliable foundation for perception, and selective attention is required to ensure that representations of relevant stimuli dominate awareness...
  67. Brain Mechanisms in Pediatric Bipolar Disorder and Attention Deficit Hyperactivit
    Mani N Pavuluri; Fiscal Year: 2010 to differentiate the alterations in cognitive and affective circuitry in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD) relative to typically developing operations...
    ROBIN PANNETON; Fiscal Year: 2002
    ..Several researchers in this area have speculated that ID speech is a powerful modulator of infant attention, leading it to be a primary candidate for affecting aspects of infant perceptual development...
  69. Attention and Memory: Mother-Child Psychophysiology and Behavior
    Martha Ann Bell; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Well-regulated attention and memory processes are critical to healthy cognitive development in childhood and beyond...
    John Richards; Fiscal Year: 2006
    The objectives are to study the development of sustained attention in young infants and to relate development in sustained attention to concurrent heart rate (HR) changes...
  71. Attentional Dysfunction and Recovery in Traumatic Brain Injury (TBI)
    ANDREW ROBERT MAYER; Fiscal Year: 2010
    ..Of all cognitive deficits following mild TBI, difficulties with attention and distractibility are one of the most commonly reported, and observed, symptoms...
  72. Analysis of human cortical networks during sustained visuospatial attention
    Michael Silver; Fiscal Year: 2009
    ..project are 1) to identify functional networks of cortical areas in the human brain that subserve visual spatial attention, and 2) to determine the effects of manipulation of synaptic levels of acetylcholine on the physiology of these ..
  73. Development of Behavioral Problems in VLBW Preschoolers
    Leslie Halpern; Fiscal Year: 2003
    ..VLBW) preterm children exhibit a greater incidence of behavioral problems, with hyperactivity and attention deficits most consistently discriminating between VLBW and normal birth weight children...
  74. Feasibility Study: Attention Measures in Persons with Alzheimer's Disease
    Catherine Cole; Fiscal Year: 2007
    ..feasibility of using repeated simple reaction time measures to study the effect of sleep disruption on vigilant attention in persons with AD...
  75. Neurodynamics of Attention: MEG, EEG, and Modeling
    Stephanie Jones; Fiscal Year: 2009
    The purpose of this proposal is to investigate the relationship between neural dynamics and attention in normal human subjects...
  76. Effect of attentional control on the expression of the negativity bias in aging
    Michael A Kisley; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Emotion and attention both work to focus our thoughts in a manner that is adaptive...
    Lawrence Marks; Fiscal Year: 2004 processing sensory information in various modalities, this research aims to understand the role of voluntary attention in perception, particularly in the detection of weak sensory stimuli...
  78. Using Attention to Understand Cortical Population Codes
    MARLENE ROCHELLE COHEN; Fiscal Year: 2010
    ..To identify the most important aspects of the population code for guiding behavior, I varied visual attention, which improves perception of an attended location or feature...
  79. Optogenetic control of attention through prefrontal synchrony
    Robert Desimone; Fiscal Year: 2010
    ..The prefrontal cortex (PFC) plays an important role in executive function, including the control of attention. Lesions of PFC impair the ability to focus attention, ignore distracters, and switch attention in a flexible ..