motor skills

Summary

Summary: Performance of complex motor acts.

Top Publications

  1. ncbi Daytime sleep condenses the time course of motor memory consolidation
    Maria Korman
    Brain Behavior Research Center, University of Haifa, Mount Carmel, Haifa 31905, Israel
    Nat Neurosci 10:1206-13. 2007
  2. pmc Brain plasticity related to the consolidation of motor sequence learning and motor adaptation
    Karen Debas
    Functional Neuroimaging Unit, Centre de Recherche de l Institut Gériatrique, Universite de Montreal, Montreal, QC, Canada H3W 1W5
    Proc Natl Acad Sci U S A 107:17839-44. 2010
  3. pmc Learning optimal adaptation strategies in unpredictable motor tasks
    Daniel A Braun
    Bernstein Center for Computational Neuroscience, Albert Ludwig University, 79104 Freiburg, Germany
    J Neurosci 29:6472-8. 2009
  4. ncbi Contributions of the basal ganglia and functionally related brain structures to motor learning
    Julien Doyon
    Functional Neuroimaging Unit, University of Montreal Geriatric Institute, Montreal, Quebec, Canada
    Behav Brain Res 199:61-75. 2009
  5. ncbi Neural correlates of motor memory consolidation
    R Shadmehr
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, 419 Traylor, Baltimore, MD 21205 2195, USA
    Science 277:821-5. 1997
  6. pmc Neuroplasticity subserving motor skill learning
    Eran Dayan
    Human Cortical Physiology and Stroke Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Neuron 72:443-54. 2011
  7. ncbi Bayesian integration in sensorimotor learning
    Konrad P Kording
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nature 427:244-7. 2004
  8. ncbi Distinct contribution of the cortico-striatal and cortico-cerebellar systems to motor skill learning
    Julien Doyon
    Department of Psychology, University of Montreal, PO Box 6128, Downtown Station, Montreal, Que, Canada H3C3J7
    Neuropsychologia 41:252-62. 2003
  9. ncbi Practice with sleep makes perfect: sleep-dependent motor skill learning
    Matthew P Walker
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Neuron 35:205-11. 2002
  10. pmc Interacting adaptive processes with different timescales underlie short-term motor learning
    Maurice A Smith
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 4:e179. 2006

Detail Information

Publications357 found, 100 shown here

  1. ncbi Daytime sleep condenses the time course of motor memory consolidation
    Maria Korman
    Brain Behavior Research Center, University of Haifa, Mount Carmel, Haifa 31905, Israel
    Nat Neurosci 10:1206-13. 2007
    ..These results suggest that the evolution of robustness to interference and the evolution of delayed gains can coincide immediately post-training and that both effects reflect sleep-sensitive processes...
  2. pmc Brain plasticity related to the consolidation of motor sequence learning and motor adaptation
    Karen Debas
    Functional Neuroimaging Unit, Centre de Recherche de l Institut Gériatrique, Universite de Montreal, Montreal, QC, Canada H3W 1W5
    Proc Natl Acad Sci U S A 107:17839-44. 2010
    ..through functional MRI (fMRI), the neuronal substrates associated with the consolidation process of two motor skills: motor sequence learning (MSL) and motor adaptation (MA)...
  3. pmc Learning optimal adaptation strategies in unpredictable motor tasks
    Daniel A Braun
    Bernstein Center for Computational Neuroscience, Albert Ludwig University, 79104 Freiburg, Germany
    J Neurosci 29:6472-8. 2009
    ..These results suggest that adaptation can become specifically tuned to identify task-specific parameters in an optimal manner...
  4. ncbi Contributions of the basal ganglia and functionally related brain structures to motor learning
    Julien Doyon
    Functional Neuroimaging Unit, University of Montreal Geriatric Institute, Montreal, Quebec, Canada
    Behav Brain Res 199:61-75. 2009
    ..These results are then put into a plausible neurobiological model of motor skill learning, which proposes an integrated view of the brain plasticity mediating this form of memory at different stages of the acquisition process...
  5. ncbi Neural correlates of motor memory consolidation
    R Shadmehr
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, 419 Traylor, Baltimore, MD 21205 2195, USA
    Science 277:821-5. 1997
    ....
  6. pmc Neuroplasticity subserving motor skill learning
    Eran Dayan
    Human Cortical Physiology and Stroke Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Neuron 72:443-54. 2011
    ..new insight into functional reorganization associated with the acquisition, consolidation, and retention of motor skills. Plastic changes involving structural reorganization in gray and white matter architecture that occur over ..
  7. ncbi Bayesian integration in sensorimotor learning
    Konrad P Kording
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nature 427:244-7. 2004
    ..The central nervous system therefore employs probabilistic models during sensorimotor learning...
  8. ncbi Distinct contribution of the cortico-striatal and cortico-cerebellar systems to motor skill learning
    Julien Doyon
    Department of Psychology, University of Montreal, PO Box 6128, Downtown Station, Montreal, Que, Canada H3C3J7
    Neuropsychologia 41:252-62. 2003
    ..e. automatization) when subjects achieve asymptotic performance, as well as during reactivation of the new skilled behavior in the retention phase...
  9. ncbi Practice with sleep makes perfect: sleep-dependent motor skill learning
    Matthew P Walker
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Neuron 35:205-11. 2002
    ..This finding of sleep-dependent motor skill improvement may have important implications for the efficient learning of all skilled actions in humans...
  10. pmc Interacting adaptive processes with different timescales underlie short-term motor learning
    Maurice A Smith
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 4:e179. 2006
    ..Our results suggest that motor adaptation depends on at least two distinct neural systems that have different sensitivity to error and retain information at different rates...
  11. ncbi Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct
    R J Nudo
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, 77030, USA
    Science 272:1791-4. 1996
    ....
  12. ncbi Encoding of motor skill in the corticomuscular system of musicians
    Reinhard Gentner
    Human Cortical Physiology and Motor Control Laboratory, Department of Neurology, University of Wuerzburg, Josef Schneider Strasse 11, Wuerzburg, Germany
    Curr Biol 20:1869-74. 2010
    How motor skills are stored in the nervous system represents a fundamental question in neuroscience...
  13. pmc Motor adaptation as a process of reoptimization
    Jun Izawa
    Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 28:2883-91. 2008
    ..Through reward-based optimization, we use the internal model to search for a better movement plan to minimize implicit motor costs and maximize rewards...
  14. pmc Sleep and the time course of motor skill learning
    Matthew P Walker
    Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA
    Learn Mem 10:275-84. 2003
    ..Finally, whereas the majority of sleep-dependent motor-skill learning develops during the first night of sleep following training, additional nights of sleep still offer continued improvements...
  15. ncbi Imaging brain plasticity during motor skill learning
    Leslie G Ungerleider
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neurobiol Learn Mem 78:553-64. 2002
    ..We also briefly review neurophysiological and psychophysical evidence for the consolidation of motor skills, and we propose a working hypothesis of its underlying neural substrate in motor sequence learning.
  16. ncbi Motor sequence learning with the nondominant left hand. A PET functional imaging study
    Scott T Grafton
    Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, 6162 Moore Hall, Dartmouth College, Hanover, NH 03755, USA
    Exp Brain Res 146:369-78. 2002
    ..Mirror transformation of the sequence by the right hand was associated with a marked increase in regional activity in the left motor cortex, consistent with a role for sequential transformation at this level of the motor output pathway...
  17. ncbi Early consolidation in human primary motor cortex
    Wolf Muellbacher
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 10, Rm 5N226, 10 Center Drive MSC 1428, Bethesda, Maryland 20892 1428, USA
    Nature 415:640-4. 2002
    ..These findings indicate that the human M1 is specifically engaged during the early stage of motor consolidation...
  18. ncbi Reorganization and plasticity in the adult brain during learning of motor skills
    Julien Doyon
    Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen Mary Street, Montreal, Quebec, H3W 1W5, Canada
    Curr Opin Neurobiol 15:161-7. 2005
    ..There has been recent behavioral, lesion and additional neuroimaging studies that have addressed the assumptions made in this theory that will help in the revision of this model...
  19. ncbi An interference effect of observed biological movement on action
    J M Kilner
    Institut des Sciences Cognitives, 67 Boulevard Pinel, Bron 69675, France
    Curr Biol 13:522-5. 2003
    ..These results suggest that the simultaneous activation of the overlapping neural networks that process movement observation and execution infers a measurable cost to motor control...
  20. pmc Neural correlates of outcome after stroke: a cross-sectional fMRI study
    N S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 126:1430-48. 2003
    ..These results further our understanding of the recovery process by demonstrating for the first time a clear relationship between task-related activation of the motor system and outcome after stroke...
  21. ncbi The neural correlates of motor skill automaticity
    Russell A Poldrack
    Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095 1563, USA
    J Neurosci 25:5356-64. 2005
    ....
  22. ncbi The musician's brain as a model of neuroplasticity
    Thomas F Münte
    Department of Neuropsychology, Otto von Guericke University, Universitatsplatz 2, Gebäude 24, 39106 Magdeburg, Germany
    Nat Rev Neurosci 3:473-8. 2002
    ..Here, we focus on the functional and anatomical differences that have been detected in musicians by modern neuroimaging methods...
  23. ncbi An implicit plan overrides an explicit strategy during visuomotor adaptation
    Pietro Mazzoni
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 26:3642-5. 2006
    ..This suggests that the motor system requires that planned and executed trajectories remain congruous in visual space, and enforces this correspondence even at the expense of an opposing explicit task goal...
  24. ncbi Functional neuroanatomical networks associated with expertise in motor imagery
    Aymeric Guillot
    CRIS, Performance Motrice, Mentale et du Matériel P3M, Universite de Lyon, Universite Claude Bernard Lyon I, 27 29 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
    Neuroimage 41:1471-83. 2008
    ..225-238], our results demonstrate that compared to skilled imagers, poor imagers not only need to recruit the cortico-striatal system, but to compensate with the cortico-cerebellar system during MI of sequential movements...
  25. pmc Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning
    Brita Fritsch
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 66:198-204. 2010
    ..We propose that tDCS may improve motor skill learning through augmentation of synaptic plasticity that requires BDNF secretion and TrkB activation within M1...
  26. pmc Infant and toddler oral- and manual-motor skills predict later speech fluency in autism
    Morton Ann Gernsbacher
    University of Wisconsin Madison, USA
    J Child Psychol Psychiatry 49:43-50. 2008
    ..Spoken and gestural communication proficiency varies greatly among autistic individuals. Three studies examined the role of oral- and manual-motor skill in predicting autistic children's speech development...
  27. pmc A computational neuroanatomy for motor control
    Reza Shadmehr
    Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, 410 Traylor Building, 720 Rutland Ave, Baltimore, MD 21205, USA
    Exp Brain Res 185:359-81. 2008
    ..Finally, functions of the primary and the premotor cortices are related to implementing the optimal control policy by transforming beliefs about proprioceptive and visual states, respectively, into motor commands...
  28. pmc Contribution of night and day sleep vs. simple passage of time to the consolidation of motor sequence and visuomotor adaptation learning
    Julien Doyon
    Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565 Queen Mary, Montreal, QC H3W 1W5, Canada
    Exp Brain Res 195:15-26. 2009
    There is increasing evidence supporting the notion that the contribution of sleep to consolidation of motor skills depends on the nature of the task used in practice...
  29. ncbi Effect of levodopa in combination with physiotherapy on functional motor recovery after stroke: a prospective, randomised, double-blind study
    K Scheidtmann
    Neurologische Klinik, D 83043 Bad, Aibling, Germany
    Lancet 358:787-90. 2001
    ..Our aim was to ascertain whether levodopa could enhance the efficacy of physiotherapy after hemiplegia...
  30. ncbi Action observation and acquired motor skills: an FMRI study with expert dancers
    B Calvo-Merino
    Institute of Movement Neuroscience, University College London and Department of Basic Psychology, Faculty of Psychology, Universidad Complutense, Madrid, Spain
    Cereb Cortex 15:1243-9. 2005
    When we observe someone performing an action, do our brains simulate making that action? Acquired motor skills offer a unique way to test this question, since people differ widely in the actions they have learned to perform...
  31. ncbi Motor imagery
    Martin Lotze
    Institute of Medical Psychology and Behavioral Neurobiology, Eberhard Karls University of Tubingen, D 72074 Tubingen, Germany
    J Physiol Paris 99:386-95. 2006
    ..Finally we provide an outlook on additional work about motor imagery important for further understanding of the topic...
  32. ncbi Awareness modifies the skill-learning benefits of sleep
    Edwin M Robertson
    Laboratory for Magnetic Brain Stimulation, Behavioral Neurology Unit, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Biol 14:208-12. 2004
    ..These results show a behavioral dissociation, based upon an individual's awareness for having learned a sequence of finger movements. Offline learning is sleep dependent for explicit skills but time dependent for implicit skills...
  33. ncbi Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury
    J Biernaskie
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada A1B 3V6
    J Neurosci 21:5272-80. 2001
    ....
  34. ncbi Fundamental movement skills and habitual physical activity in young children
    Abigail Fisher
    University of Glasgow Division of Developmental Medicine, Yorkhill Hospitals, Glasgow, Scotland
    Med Sci Sports Exerc 37:684-8. 2005
    ..To test for relationships between objectively measured habitual physical activity and fundamental movement skills in a relatively large and representative sample of preschool children...
  35. ncbi Computerized arm training improves the motor control of the severely affected arm after stroke: a single-blinded randomized trial in two centers
    S Hesse
    Klinik Berlin, Neurological Rehabilitation, Charite, Berlin, Germany
    Stroke 36:1960-6. 2005
    ....
  36. ncbi Fundamental movement skills in children and adolescents: review of associated health benefits
    David R Lubans
    School of Education, University of Newcastle, Callaghan Campus, Newcastle, New South Wales, Australia
    Sports Med 40:1019-35. 2010
    ..More longitudinal and intervention research examining the relationship between FMS competency and potential psychological, physiological and behavioural outcomes in children and adolescents is recommended...
  37. ncbi Cortical synaptogenesis and motor map reorganization occur during late, but not early, phase of motor skill learning
    Jeffrey A Kleim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4
    J Neurosci 24:628-33. 2004
    ..We propose that motor map reorganization and synapse formation do not contribute to the initial acquisition of motor skills but represent the consolidation of motor skill that occurs during late stages of training.
  38. ncbi Central mechanisms of motor skill learning
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Building 49, Room 2A50, Bethesda, Maryland 20892, USA
    Curr Opin Neurobiol 12:217-22. 2002
    ..This architecture accounts for the seemingly diverse features of motor learning...
  39. ncbi Repetitive transcranial magnetic stimulation-induced corticomotor excitability and associated motor skill acquisition in chronic stroke
    Yun Hee Kim
    Department of Physical Therapy, Graduate School of Rehabilitation Therapy, Yonsei University, Wonju City, Kangwon do corrected Republic of Korea
    Stroke 37:1471-6. 2006
    ..This study investigated high-frequency rTMS-induced cortical excitability and the associated motor skill acquisition in chronic stroke patients...
  40. pmc Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing
    Catherine J Stoodley
    Ataxia Unit, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 175 Cambridge Street, Boston, MA 02114, USA
    Cortex 46:831-44. 2010
    ..These observations provide testable hypotheses for future investigations...
  41. ncbi Similar network activated by young and old adults during the acquisition of a motor sequence
    Sander M Daselaar
    Center for Cognitive Neuroscience, Duke University, Box 90999, LSRC Bldg, Rm B243N, Durham, NC 27708, USA
    Neurobiol Aging 24:1013-9. 2003
    ....
  42. ncbi Cortical activation patterns during complex motor tasks in piano players and control subjects. A functional magnetic resonance imaging study
    T Krings
    Department of Neuroradiology, University Hospital of the Technical University, Aachen, Germany
    Neurosci Lett 278:189-93. 2000
    ..For the same movements lesser neurons need to be recruited. The different volume of the activated ortical areas might therefore reflect the different effort necessary for motor performance in both groups...
  43. ncbi Probability of regaining dexterity in the flaccid upper limb: impact of severity of paresis and time since onset in acute stroke
    Gert Kwakkel
    Rehabilitation Centre De Hoogstraat, University Medical Centre, Utrecht, The Netherlands
    Stroke 34:2181-6. 2003
    ....
  44. ncbi Reliability and concurrent validity of the movement assessment battery for children
    R V Croce
    Department of Kinesiology, University of New Hampshire, Durham 03824, USA
    Percept Mot Skills 93:275-80. 2001
    ..These results support the use of the Movement battery as a measure of motor ability in children, ages 5 to 12 years...
  45. ncbi Motor control strategies revealed in the structure of motor variability
    Mark L Latash
    Department of Kinesiology, Pennsylvania State University, University Park 16802, USA
    Exerc Sport Sci Rev 30:26-31. 2002
    ..The hypothesis and associated computational apparatus have great potential for application in the areas of motor rehabilitation and motor skill acquisiton...
  46. pmc Dual adaptation supports a parallel architecture of motor memory
    Jeong Yoon Lee
    Department of Computer Science and Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90089, USA
    J Neurosci 29:10396-404. 2009
    ..Our result suggests that during motor adaptation, fast and slow processes are updated simultaneously from the same motor learning errors...
  47. pmc Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits
    Matthias Groszer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Curr Biol 18:354-62. 2008
    ....
  48. ncbi Hemispheric differences in the relationship between corticomotor excitability changes following a fine-motor task and motor learning
    Michael I Garry
    Discipline of Physiology, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide SA 5005, Australia
    J Neurophysiol 91:1570-8. 2004
    ..This asymmetry may reflect different behavioral strategies for performance improvement with left and right upper limb in this task or hemispheric differences in the control of skilled hand movements...
  49. ncbi A neuropsychological theory of motor skill learning
    D B Willingham
    Department of Psychology, University of Virginia, Charlottesville 22903 USA
    Psychol Rev 105:558-84. 1998
    ..It also makes a number of predictions about the purely cognitive, including accounts of mental practice, the representation of motor skill, and the interaction of conscious and unconscious processes in motor skill learning...
  50. ncbi Learning-performance distinction and memory processes for motor skills: a focused review and perspective
    Shailesh S Kantak
    Motor Behavior and Neurorehabilitation Laboratory, Division of Biokinesiology and Physical Therapy at the Herman Ostrow School of Dentistry, University of Southern California, 1540 E Alcazar Street, CHP 155, Los Angeles, CA 90089, USA
    Behav Brain Res 228:219-31. 2012
    ..when challenging practice conditions may impair practice performance, but enhance long-term retention of motor skills. A review of motor learning studies with a specific focus on comparing differences in performance between that ..
  51. pmc Cortical plasticity following motor skill learning during mental practice in stroke
    Stephen J Page
    Department of Physical Medicine and Rehabilitation, University of Cincinnati Academic Medical Center, Cincinnati, Ohio 45267 0394, USA
    Neurorehabil Neural Repair 23:382-8. 2009
    ..As a next step, this 10-subject case series examined the possibility that cortical plasticity is a mechanism underlying the treatment effect of MP when combined with RTP...
  52. ncbi Kinesthetic imagery and tool-specific modulation of corticospinal representations in expert tennis players
    Alissa D Fourkas
    Dipartimento di Psicologia, Universita degli Studi di Roma La Sapienza, I 00185 Roma, Italia
    Cereb Cortex 18:2382-90. 2008
    ..Neurophysiological and subjective data converge to suggest a key role of long-term experience in modulating sensorimotor body representations during mental simulation of sports...
  53. ncbi Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats
    T A Jones
    Department of Psychology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 19:10153-63. 1999
    ..experience effects on synaptic plasticity after brain damage, the present study examined the effects of complex motor skills training (the acrobatic task) on synaptic changes in layer V of the motor cortex opposite unilateral damage to ..
  54. pmc Dopamine in motor cortex is necessary for skill learning and synaptic plasticity
    Katiuska Molina-Luna
    Clinical Neurorehabilitation, Department of Neurology, University of Zurich, Zurich, Switzerland
    PLoS ONE 4:e7082. 2009
    Preliminary evidence indicates that dopamine given by mouth facilitates the learning of motor skills and improves the recovery of movement after stroke. The mechanism of these phenomena is unknown...
  55. pmc Motor system activation after subcortical stroke depends on corticospinal system integrity
    Nick S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 129:809-19. 2006
    ..Secondary motor regions are less efficient at generating motor output so this reorganization can only be considered partially successful in reducing motor impairment after stroke...
  56. ncbi Motor-learning-related changes in piano players and non-musicians revealed by functional magnetic-resonance signals
    M Hund-Georgiadis
    Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
    Exp Brain Res 125:417-25. 1999
    ..In summary, the involvement of primary and secondary motor cortices in motor learning is dependent on experience. Interhemispheric transfer effects are present...
  57. ncbi Neural substrates of intermanual transfer of a newly acquired motor skill
    M A Perez
    Human Cortical Physiology Section and Stroke Neurorehabilitation Clinic, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892 1430
    Curr Biol 17:1896-902. 2007
    ..These findings provide direct evidence for an SMA-based mechanism that supports intermanual transfer of motor-skill learning...
  58. pmc Relationship of aerobic fitness and motor skills with memory and attention in preschoolers (Ballabeina): a cross-sectional and longitudinal study
    Iris Niederer
    Institute of Exercise and Health Sciences, University of Basel, Birsstrasse 320B, 4052 Basel, Switzerland
    BMC Pediatr 11:34. 2011
    The debate about a possible relationship between aerobic fitness and motor skills with cognitive development in children has recently re-emerged, because of the decrease in children's aerobic fitness and the concomitant pressure of ..
  59. ncbi Pickup of essential kinematics underpins expert perception of movement patterns
    Bruce Abernethy
    Institute of Human Performance, The University of Hong Kong
    J Mot Behav 39:353-67. 2007
    ..g., W. Prinz, 1997), some important differences were evident between the characteristics of the experts' movement prediction and those of expert movement production...
  60. ncbi The serial reaction time task: implicit motor skill learning?
    Edwin M Robertson
    Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 27:10073-5. 2007
  61. ncbi Neonatal brain structure on MRI and diffusion tensor imaging, sex, and neurodevelopment in very-low-birthweight preterm children
    Jessica Rose
    Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Dev Med Child Neurol 51:526-35. 2009
    ..Results indicate that the higher incidence of abnormal neurodevelopment in preterm males relates to greater incidence and severity of brain abnormalities, including reduced PLIC and splenium development...
  62. ncbi Back seat driving: hindlimb corticospinal neurons assume forelimb control following ischaemic stroke
    Michelle Louise Starkey
    Department of Health Sciences and Technology, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland
    Brain 135:3265-81. 2012
    ....
  63. pmc A distributed left hemisphere network active during planning of everyday tool use skills
    Scott H Johnson-Frey
    Department of Psychology, University of Oregon, Eugene, OR 97403 1227, USA
    Cereb Cortex 15:681-95. 2005
    ..We suggest that this left lateralized network constitutes a neural substrate for the interaction of semantic and motoric representations upon which meaningful skills depend...
  64. pmc How is a motor skill learned? Change and invariance at the levels of task success and trajectory control
    Lior Shmuelof
    Motor Performance Laboratory, The Neurological Institute, Columbia University, New York, New York, USA
    J Neurophysiol 108:578-94. 2012
    ..We propose that motor skill acquisition can be characterized as a slow reduction in movement variability, which is distinct from faster model-based learning that reduces systematic error in adaptation paradigms...
  65. ncbi Relationship of physical activity with motor skills, aerobic fitness and body fat in preschool children: a cross-sectional and longitudinal study (Ballabeina)
    F Bürgi
    Institute of Exercise and Health Science, University of Basel, Basel, Switzerland
    Int J Obes (Lond) 35:937-44. 2011
    ..Adiposity, low aerobic fitness and low levels of activity are all associated with clustered cardiovascular disease risk in children and their high prevalence represents a major public health concern...
  66. ncbi Capacity, capability, and performance: different constructs or three of a kind?
    Laura Holsbeeke
    Rehabilitation Center De Hoogstraat, Center of Excellence for Rehabilitation Medicine, Utrecht, The Netherlands
    Arch Phys Med Rehabil 90:849-55. 2009
    ....
  67. ncbi Fine modulation in network activation during motor execution and motor imagery
    Ana Solodkin
    Department of Neurology and Brain Research Imaging Center, The University of Chicago, Chicago, IL 60637, USA
    Cereb Cortex 14:1246-55. 2004
    ..Finally, this study highlights the role of the connection of superior parietal lobule to the supplementary motor area in both types of motor imagery...
  68. pmc Experience-dependent changes in cerebellar contributions to motor sequence learning
    Julien Doyon
    Department of Psychology, University of Montreal, Montreal, QC, Canada H3C 3J7
    Proc Natl Acad Sci U S A 99:1017-22. 2002
    ....
  69. ncbi Hand function in relation to brain lesions and corticomotor-projection pattern in children with unilateral cerebral palsy
    Linda Holmström
    Department of Woman and Child Health, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    Dev Med Child Neurol 52:145-52. 2010
    ..To investigate relationships between hand function, brain lesions, and corticomotor projections in children with unilateral cerebral palsy (CP)...
  70. ncbi Reciprocal changes in input-output curves of motor evoked potentials while learning motor skills
    Makoto Suzuki
    Faculty of Medical Technology, Niigata University of Health and Welfare, Niigata, Japan
    Brain Res 1473:114-23. 2012
    ..The present findings validate the IO curves simultaneously measured for reciprocal muscles, and suggest that motor skill training could induce reciprocal change in corticospinal excitability...
  71. pmc Long-term motor training induced changes in regional cerebral blood flow in both task and resting states
    Jinhu Xiong
    Department of Radiology, University of Iowa, Iowa City, 52242, USA
    Neuroimage 45:75-82. 2009
    ..Combining changes in resting state with activation data should greatly enhance our understanding of the mechanisms of motor-skill learning...
  72. pmc Consolidating the effects of waking and sleep on motor-sequence learning
    Timothy P Brawn
    Department of Psychology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 30:13977-82. 2010
    ..These observations indicate that current theories of memory consolidation that have been formulated to explain sleep-dependent performance enhancements are insufficient to explain the range of behavioral changes associated with sleep...
  73. pmc Learning of a sequential motor skill comprises explicit and implicit components that consolidate differently
    M Felice Ghilardi
    CUNY Medical School, Department of Physiology and Pharmacology, Harris Hall Suite 210, 138th and Convent Avenue, New York, NY 10031, USA
    J Neurophysiol 101:2218-29. 2009
    ..We propose that an essential feature of motor skill learning is the process by which discrete explicit task elements are combined with continuous implicit features of movement to form flawless sequential actions...
  74. ncbi Tactile stimulation promotes motor recovery following cortical injury in adult rats
    Robbin L Gibb
    Canadian Centre for Behavioral Neuroscience, The University of Lethbridge, Alberta, Canada
    Behav Brain Res 214:102-7. 2010
    ..Taken together, these data show tactile stimulation can improve motor performance in adult animals and the improvement is correlated with dendritic sprouting. This finding could have implications for therapy in humans following stroke...
  75. ncbi Motor improvements after focal cortical ischemia in adult rats are mediated by compensatory mechanisms
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 162:71-82. 2005
    ..The finding that reaching success was not related to lesion size supports the idea that the degree of adaptive behavior after cortical ischemia depends on plastic properties of the remaining intact tissue...
  76. ncbi Sleep-dependent motor memory plasticity in the human brain
    M P Walker
    Sleep and Neuroimaging Laboratory, FD Feldberg 862, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuroscience 133:911-7. 2005
    ..This evidence of an overnight, systems-level change in the representation of a motor memory holds important implications for acquiring real-life skills and in clinical rehabilitation following brain trauma, such as stroke...
  77. ncbi Motor skills in children aged 7-10 years, diagnosed with autism spectrum disorder
    Caroline P Whyatt
    School of Psychology, Queen s University Belfast, 18 30 Malone Road, Belfast, BT9 5BN, Northern Ireland, UK
    J Autism Dev Disord 42:1799-809. 2012
    This study used the Movement Assessment Battery for Children (M-ABC2) to assess motor skills in children aged 7-10 years with autism (n = 18) in comparison to two groups of age-matched typically developing children; a receptive ..
  78. ncbi Motor and gestural performance in children with autism spectrum disorders, developmental coordination disorder, and/or attention deficit hyperactivity disorder
    Deborah Dewey
    Department of Pediatrics, University of Calgary, Alberta, Canada
    J Int Neuropsychol Soc 13:246-56. 2007
    ..b>Motor skills were assessed with the Bruininks-Oseretsky Test of Motor Proficiency Short Form, and gestural skills were ..
  79. ncbi Enhanced cortical activation in the contralesional hemisphere of chronic stroke patients in response to motor skill challenge
    Judith D Schaechter
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Cereb Cortex 18:638-47. 2008
    ..The findings of the current study suggest that successful recovery of motor skill after hemiparetic stroke involves participation of the contralesional cortical network...
  80. ncbi Two classes of movements in motor control
    Elizabeth B Torres
    Psychology Department Busch Campus, Rutgers University, 152 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    Exp Brain Res 215:269-83. 2011
    ....
  81. pmc Implicit sequence-specific motor learning after subcortical stroke is associated with increased prefrontal brain activations: an fMRI study
    Sean K Meehan
    Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada
    Hum Brain Mapp 32:290-303. 2011
    ..This study is the first to highlight the importance of the prefrontal cortex for implicit sequence-specific motor learning after stroke...
  82. ncbi Task-specific training: evidence for and translation to clinical practice
    Isobel J Hubbard
    Acute Stroke Unit, John Hunter Hospital, Hunter New England Area Health Service, Newcastle, and The University of Newcastle, Newcastle, Australia
    Occup Ther Int 16:175-89. 2009
    ....
  83. ncbi Obesity and skill attainment in early childhood
    John Cawley
    Department of Policy Analysis and Management, Cornell University, Ithaca, NY 14853, USA
    Econ Hum Biol 6:388-97. 2008
    ..estimate models of developmental functioning in four critical areas (verbal skills, activities of daily living, motor skills, and social skills) as a function of various measures of weight (including body mass index and obesity) ..
  84. ncbi Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function
    Cindy T J van Velthoven
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands
    J Neurosci 30:9603-11. 2010
    ..We propose that the function of MSCs is dictated by adaptive specific signals provided by the damaged and regenerating brain...
  85. pmc Mechanisms controlling motor output to a transfer hand after learning a sequential pinch force skill with the opposite hand
    Mickael Camus
    Human Cortical Physiology and Stroke Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Clin Neurophysiol 120:1859-65. 2009
    ..We hypothesized that intermanual transfer of learning such a task would reveal intracortical changes within M1...
  86. ncbi Instructional climates in preschool children who are at-risk. Part I: object-control skill development
    Leah E Robinson
    Department of Kinesiology, Auburn University, Auburn, AL 36849 5323, USA
    Res Q Exerc Sport 80:533-42. 2009
    ..The authors conclude that developmentally and instructionally appropriate climates are beneficial to OC skill learning, along with the need for "planned" movement experiences in motor learning environments...
  87. ncbi Motor learning in children: feedback effects on skill acquisition
    Katherine J Sullivan
    Division of Biokinesiology and Physical Therapy at the School of Dentistry, University of Southern California, 1540 E Alcazar St, CHP 155, Los Angeles, CA 90089 9006, USA
    Phys Ther 88:720-32. 2008
    ..The purpose of this study was to determine the effect of different relative frequencies of feedback on skill acquisition in children compared with young adults...
  88. ncbi Bimanual coordination and corpus callosum microstructure in young adults with traumatic brain injury: a diffusion tensor imaging study
    Karen Caeyenberghs
    Motor Control Laboratory, Research Center for Movement Control and Neuroplasticity, K U Leuven, Belgium
    J Neurotrauma 28:897-913. 2011
    ..This study provides evidence that structural alterations of several subregional callosal fibers in adults with TBI are associated with differential behavioral manifestations of bimanual motor functioning...
  89. ncbi Developmental coordination disorder and other motor control problems in girls with autism spectrum disorder and/or attention-deficit/hyperactivity disorder
    Svenny Kopp
    Goteborg University, Institute of Neuroscience and Physiology, Sweden
    Res Dev Disabil 31:350-61. 2010
    ..Their motor problems contribute to reduced activity in daily life even when the effects of IQ have been partialled out...
  90. ncbi The effect of amblyopia on fine motor skills in children
    Ann L Webber
    School of Optometry and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    Invest Ophthalmol Vis Sci 49:594-603. 2008
    In an investigation of the functional impact of amblyopia in children, the fine motor skills of amblyopes and age-matched control subjects were compared...
  91. ncbi Motor development in very preterm and very low-birth-weight children from birth to adolescence: a meta-analysis
    Jorrit F de Kieviet
    Department of Clinical Neuropsychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    JAMA 302:2235-42. 2009
    ..There is increasing evidence that very preterm birth and VLBW have a considerable effect on motor development, although findings are inconsistent...
  92. pmc Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill
    Henry H Yin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, 5625 Fishers Lane, MSC 9411, Bethesda, Maryland 20852 9411, USA
    Nat Neurosci 12:333-41. 2009
    ..These findings demonstrate that region- and pathway-specific plasticity sculpts the circuits involved in the performance of the skill as it becomes automatized...
  93. ncbi Neural substrates of motor memory consolidation depend on practice structure
    Shailesh S Kantak
    Motor Behavior and Neurorehabilitation Laboratory, Division of Biokinesiology and Physical Therapy at the Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California, USA
    Nat Neurosci 13:923-5. 2010
    ..We conclude that neural substrates of motor-memory consolidation are modulated by practice structure...
  94. pmc Sleep-dependent learning and motor-skill complexity
    Kenichi Kuriyama
    Center for Sleep and Cognition, Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Learn Mem 11:705-13. 2004
    ..4% improvement. Together, these findings suggest that the sleep-dependent learning process selectively provides maximum benefit to motor-skill procedures that proved to be most difficult prior to sleep...
  95. ncbi Long-term training affects cerebellar processing in skilled keyboard players
    Susan Koeneke
    Department of Neuropsychology, University of Zurich, Treichlerstrasse 10, CH 8032 Zurich, Switzerland
    Neuroreport 15:1279-82. 2004
    ..For the same movements fewer neurons need to be recruited. The different volume of the activated cortical areas might therefore reflect the different effort necessary for motor performance in both groups...
  96. ncbi Coarticulation in fluent fingerspelling
    Thomas E Jerde
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 23:2383-93. 2003
    ..The simultaneous occurrence of dissimilation in some joints and assimilation in others demonstrates an unprecedented level of parallel control of individual joint rotations in an essentially serial task...
  97. ncbi Dopaminergic projections from midbrain to primary motor cortex mediate motor skill learning
    Jonas A Hosp
    Clinical Neurorehabilitation, Department of Neurology, University of Zurich, CH 8091 Zurich, Switzerland
    J Neurosci 31:2481-7. 2011
    ..Because VTA dopaminergic neurons are known to signal rewards, the VTA-to-M1 projection is a candidate for relaying reward information that could directly support the encoding of a motor skill within M1...
  98. pmc Motor sequence learning increases sleep spindles and fast frequencies in post-training sleep
    Amelie Morin
    Centre d Etude du Sommeil et des Rythmes Biologiques, Laboratoire de chronobiologie, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    Sleep 31:1149-56. 2008
    ..To investigate polysomnographic (PSG) sleep and NREM sleep characteristics, including sleep spindles and spectral activity involved in offline consolidation of a motor sequence learning task...
  99. ncbi Limited transfer of learning between unimanual and bimanual skills within the same limb
    Daichi Nozaki
    Centre for Neuroscience Studies, Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Nat Neurosci 9:1364-6. 2006
    ..These results suggest partial, but not complete, overlap in the learning processes involved in the acquisition of unimanual and bimanual skills...
  100. ncbi The impact of stroke on the performance of grasping: usefulness of kinetic and kinematic motion analysis
    Dennis A Nowak
    Department of Neurology, University of Cologne, Cologne, Germany
    Neurosci Biobehav Rev 32:1439-50. 2008
    ....
  101. ncbi Improvement of dexterity by single session low-frequency repetitive transcranial magnetic stimulation over the contralesional motor cortex in acute stroke: a double-blind placebo-controlled crossover trial
    Joachim Liepert
    Department of Neurology, University Hospital, Freiburg, Germany
    Restor Neurol Neurosci 25:461-5. 2007
    ..We investigated if inhibitory 1~Hz repetitive transcranial magnetic stimulation (rTMS) over the contralesional M1 improved motor performance of the affected hand in acute stroke...

Research Grants73

  1. Neuroprotection with serpins during cardiac surgery
    Richard A Jonas; Fiscal Year: 2010
    ..Alternatively it can manifest itself as a generalized decline in cognitive and motor skills. Aprotinin, a "SERPIN" (serine protease inhibitor), reduces bleeding after cardiopulmonary bypass (CPB)...
  2. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    Donald G Phinney; Fiscal Year: 2010
    ..various periods up to 1 year post-transplantation, the health, development, behavior as well as cognitive and motor skills of each transplant recipient will be evaluated using a battery of age appropriate tests and compared to sham-..
  3. Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood
    Kimberly Yolton; Fiscal Year: 2010
    ..The study will extend follow-up of this cohort to include assessments or development, cognition, motor skills, and behaviors at ages 4, 5, and 6 in an effort to examine the effects of postnatal exposure to insecticides...
  4. How Do Immature Perceptual-Motor Skills Put Child Cyclists at Risk for Injury?
    Jodie M Plumert; Fiscal Year: 2010
    ..apos; ..
  5. Childhood After Preterm Birth: The Preschool Years
    LISA MCELANEY; Fiscal Year: 2007
    ..about the likely needs of infants and toddlers who were born preterm in areas such as cognition, visual and motor skills, speech and language, and executive function...
  6. Effects of Testosterone and Genetic Factors on Psychological and Motor Function i
    NICOLE RENEE TARTAGLIA; Fiscal Year: 2013
    ..with KS have increased rates of verbal cognitive impairments, executive dysfunction, psychosocial problems, and motor skills deficits...
  7. Sensorimotor Control of the Human Orofacial System
    Steven M Barlow; Fiscal Year: 2012
    ..oral stimulation therapy can effectively accelerate development of suck and feeding skills, enhance brain development, decrease the length of hospitalization, and improve speech-language and motor skills measured at 3 years of age.
  8. Behavioral therapy to treat urinary symptoms in Parkinson's disease
    ELIZABETH CAMILLE VAUGHAN; Fiscal Year: 2012
    ..Exercise-based behavioral interventions for UI require individuals to learn motor skills (PFME) and implement an adaptive strategy...
  9. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2012
    ..of the mechanisms of supraspinal control of spinal cord plasticity would elucidate the acquisition of motor skills and should lead to novel methods for inducing and guiding recovery of function after injury or disease...
  10. Role of Target-derived FGFs in Maintaining and Repairing Synapses
    Gregorio Valdez; Fiscal Year: 2013
    ..seek to discover and manipulate molecules that act to maintain synapses, and thereby prevent the decline of motor skills that occur with normal aging and in blunting the effects of a multitude of age-related neurodegenerative ..
  11. Neurochemical &Behavioral Correlates of ETOH Effects
    Rueben A Gonzales; Fiscal Year: 2013
    ..Research on the behavioral effects of ethanol will include its influence on motor skills, reinforcement, anxiety, and withdrawal (Harris, Gonzales)...
  12. Protection of Developing White Matter during Cardiac Surgery
    Richard A Jonas; Fiscal Year: 2013
    ..of development of children following surgery for congenital heart disease have documented worse outcomes for motor skills than cognitive abilities...
  13. Long term consequences of white matter damage by perinatal hyperoxia.
    Vittorio Gallo; Fiscal Year: 2013
    ..properties such as velocity and compound action potentials, and ii) changes in motor behavior using the motor skills sequence task test...
  14. Improving Fine Motor Skill Development to Promote Mathematical Ability
    DAVID W GRISSMER; Fiscal Year: 2010
    ..Recent neuroscience and empirical research suggests that lagging fine motor skills in kindergarten and first grade may impact cognitive skills, especially math skills, at 3rd and 5th grade...
  15. Brain metabolism and neuroprotection in cardiopulmonary bypass
    Anna Pastuszko; Fiscal Year: 2012
    ..impaired executive function, expressive speech and language abnormalities, impaired visual-spatial and visual-motor skills, attention deficit/hyperactivity disorder, motor delays, and learning disabilities The neuropathological basis ..
  16. Early-life phthalate exposure, thyroid function and child cognitive development
    ROBIN MARJORIE WHYATT; Fiscal Year: 2013
    ..with phthalate-induced reductions in thyroid function (intelligence, attention, executive function and motor skills)...
  17. Childhood Leukemia: Oxidative Stress, Cognitive Changes &Academic Outcomes
    IDA MARIE MOORE; Fiscal Year: 2013
    ..stress, and are important for cognitive abilities, such as working memory, learning, visual-spatial and visual-motor skills. Oxidative stress as a mechanism of methotrexate-induced CNS injury that may lead to cognitive declines and ..
  18. MYOSIN GENE DIVERSITY AND FUNCTION
    LESLIE ANNE LEINWAND; Fiscal Year: 2013
    ..Since the cerebellum controls motor skills and coordination and muscle spindles are important for posture and gait, we hypothesize that MYH7B plays ..
  19. Physical Activity to Modify Sequelae and QOL in Childhood ALL: A Nursing Trial
    Cheryl Lorane Cox; Fiscal Year: 2013
    ..be tested for its effect on: 1) physical function outcomes (muscle strength, range of motion, endurance, gross motor skills), bone density and bone mineral content (135 weeks only);and 2) HRQL...
  20. Neurophysiology of Receptive Speech in Rett Syndrome
    John J Foxe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The loss of acquired language and motor skills are two main diagnostic criteria for Rett Syndrome (RTT), a devastating developmental disorder caused by known mutations in the MECP2 gene...
  21. Longitudinal study of exposure to PBDEs and PFCs and child neurobehavior
    Kimberly Yolton; Fiscal Year: 2013
    ..will systematically examine their associations with thyroid function, cognition, learning and memory, motor skills, attention and executive function, and behavior from age 1 to 8 years...
  22. Near Infrared Brain Imaging for Guiding Treatment in Children with Cerebral Palsy
    Georgios Alexandrakis; Fiscal Year: 2013
    ..This motor deficit profoundly affects a child's ability to develop age-typical motor skills and to engage fully in play, exploration and self-help activities...
  23. Viral-induced demyelination and neural stem cell-mediated remyelination
    Thomas E Lane; Fiscal Year: 2013
    ..neural stem cells (NSCs) into MHV- infected mice with established demyelination results in improved motor skills associated with extensive remyelination...
  24. Examining the Dynamic Relationship between Motor Competence and Physical Activity
    JACQUELINE DAWN GOODWAY; Fiscal Year: 2010
    ..This study aims to investigate how competence in motor skills, perceptions of motor competence, and fitness influence a child's physical activity patterns and obesity ..
  25. Physically Realistic Virtual Surgery
    DANIEL BOUGERE JONES; Fiscal Year: 2013
    ..e., training in hand-eye coordination and motor skills necessary for tasks such as tool movement, cutting, suturing, etc with little training in cognitive skills ..
  26. NOVEL LYSOSOMAL ENZYME DEFICIENT IN BATTEN DISEASE
    Peter Lobel; Fiscal Year: 2013
    ..Disease progression is characterized by increasingly severe seizures, loss of vision and motor skills, and dementia. Early death is inevitable, typically at 8-15 years of age...
  27. The Efficacy of the Neurotrophic Factor CDNF in Treating Parkinsonian Symptoms
    Amanda M Dettmer; Fiscal Year: 2011
    ..how well CDNF protects against the progression of motor deficits induced by MPTP by analyzing gross and fine motor skills in the home pen setting, on the Automated Movement Tracking system, on the monkey Motor Assessment Panel, and ..
  28. Clinical and Neuropsychological Investigations in Batten Disease
    Jonathan W Mink; Fiscal Year: 2010
    ..most common early symptoms of JNCL are vision loss, seizures dementia, behavioral difficulties, and impaired motor skills. As the disease progresses, the child becomes increasingly disabled and there is a substantial caregiver burden...
  29. Piloting Treatment with Insulin-Like Growth Factor-1 in Phelan-McDermid Syndrome
    Alexander Kolevzon; Fiscal Year: 2013
    ..distinct genetic risk genes and one example is SHANK3 deficiency, characterized by global developmental delay, motor skills deficits, delayed or absent speech, and ASD...
  30. Subtypes and Associated Risk Factors in Stuttering
    Nicoline Grinager Ambrose; Fiscal Year: 2013
    ..stuttering maps the longitudinal pathways of stuttering development in preschool children across the domains of motor skills, language skills, and temperament/personality in relation to fundamental epidemiologic and genetic factors...
  31. ADAPTIVE PLASTICITY IN THE SPINAL STRETCH REFLEX
    JONATHAN RICKEL WOLPAW; Fiscal Year: 2012
    ..THE SPINAL STRETCH REFLEX" ABSTRACT Throughout life, the nervous system acquires and maintains many different motor skills. How this is accomplished is one of the central problems of neuroscience research...
  32. DTI as a tool to identify infants with Krabbe Disease in need of urgent treatment
    Maria L Escolar; Fiscal Year: 2012
    ..Once the myelin sheath is destroyed, severe degeneration of mental and motor skills ensue...
  33. AMPA receptor attenuation as a new therapeutic approach for Batten disease
    David A Pearce; Fiscal Year: 2010
    ..injection of the specific AMPA antagonist, EGIS-8332, resulted in an immediate improvement of their motor skills confirming that an abnormally increased AMPA receptor activity contributes to the motor coordination deficit at ..
  34. Injury and adaptation in the developing rat corticospinal and rubrospinal tracts
    JASON BRANT CARMEL; Fiscal Year: 2013
    ..We predict that there will be incomplete recovery of the specialized motor skills. For functions that do recover, we will temporarily inactivate each of the two spared pathways, by infusing an ..
  35. Repairing maladaptive corticospinal tract development
    John H Martin; Fiscal Year: 2013
    ..Whereas this could help restore function, since the RST and ReST functions are limited compared with the CST, motor skills remain impaired. Stronger brain stem systems, we propose, means a weakened CST. !
  36. Hemifacial Microsomia: Psychosocial and Other Sequelae
    Martha M Werler; Fiscal Year: 2013
    ..academic achievement, speech and language, memory, executive function, processing speed, and perceptual motor skills. Hearing, vision, and speech impairments;sleep disordered breathing;and anesthesia exposure may be in the ..
  37. VISION SUBSTITUTION THROUGH THE TONGUE
    Aimee Arnoldussen; Fiscal Year: 2009
    ..Pilot data shows that TVSS users develop new perceptual motor skills in the first few hours of training...
  38. Reducing Gait Asymmetry in Lower-LImb Amputees Using Real-Time Rehab to Train-to-
    Stacy J Morris Bamberg; Fiscal Year: 2013
    ..immediately following the removal of the limb and uses a variety of activities to improve muscle strength and motor skills, restore daily activities, and improve independence, but fails to quantitatively address the typical force and ..
  39. Development and Validation of a Virtual Electrosurgical Skill Trainer (VEST)
    DANIEL BOUGERE JONES; Fiscal Year: 2013
    ..e., training for hand-eye coordination and motor skills necessary for tasks such as tool movement, cutting, suturing, etc), none exists specifically for ..
  40. Bone Mineral Accretion in Young Children
    Babette S Zemel; Fiscal Year: 2013
    ..Pronounced changes in gross motor skills, locomotion and physical activity also occur in early childhood...
  41. The COPA vesicle protein and pathogenesis of spinal muscular atrophy
    Elliot J Androphy; Fiscal Year: 2013
    ..increased levels of alpha-COP and COPI vesicles promote SMN dependent cargo delivery to the axon and restore motor skills and increase lifespan...
  42. VARIABILITY AND STABILITY IN SKILL ACQUISITION
    Dagmar Sternad; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The acquisition of perceptual-motor skills and their adaptation to changing task demands is fundamental to everyday life...
  43. Spatial and Temporal Scales of Motor Sequence Learning
    SCOTT THOMAS GRAFTON; Fiscal Year: 2013
    ..in humans to study the neural substrates for off-line consolidation of three types of newly acquired motor skills: sequencing, visuomotor and dynamic adaptation...
  44. Sleepiness in Parkinson's Disease
    Seiji Nishino; Fiscal Year: 2013
    ..with Parkinson's disease (PD), a chronically progressive neurodegenerative disease that often impairs motor skills (muscle rigidity, tremor and bradykinesia), have suffered from excessive daytime sleepiness (EDS)...
  45. Evaluation of a Massachusetts physical activity policy for child care
    SARA ELIZABETH NEELON; Fiscal Year: 2012
    ..In preschool-aged children, regular exercise decreases obesity risk, improves motor skills, and enhances cardiovascular function...
  46. Neural mechanisms underlying vocal learning in the songbird
    Bence P Olveczky; Fiscal Year: 2012
    ..system in which to pursue this goal, as it acquires its song in much the same way that we learn many of our motor skills, including speech...
  47. Learning and adaptation of Multi-Joint Arm Movement
    FERDINANDO ALESSANDRO MUSSA-IVALDI; Fiscal Year: 2012
    ..These representations are the basis for the recovery of performance without the need for relearning motor skills. Adaptive mechanisms will be investigated for the recovery of force control after a change in the mechanical ..
  48. Function of basal ganglia-cortical circuits in vocal learning in early life
    Satoshi Kojima; Fiscal Year: 2013
    ..a great and rare opportunity to study the mechanisms underlying basal ganglia-dependent learning of complex motor skills in early life. One of the major obstacles in studying song learning mechanisms is complexity of the behavior...
  49. Sensor-based technology in the study of motor skills in infants at risk for ASD
    Jana M Iverson; Fiscal Year: 2012
    ..literature on motor concerns in ASD, relatively little attention has been devoted to the early development of motor skills in HR infants...
  50. Motor Learning in a Customized Body-Machine Interface for Persons with Paralysis
    FERDINANDO ALESSANDRO MUSSA-IVALDI; Fiscal Year: 2013
    ..train spinal-cord injury survivors to skillfully operate a powered wheelchair using their enhanced upper body motor skills and customized interface parameters...
  51. Role of the Olivo-Cerebellar Network in Motor Coordination and Learning
    Rodolfo R Llinas; Fiscal Year: 2011
    ..4. Motor skills acquisition abilities (rotorod test) and motricity/postural compensation properties following unilateral ..
  52. Effects of Therapeutic Horseback Riding on Children and Adolescents with Autism S
    Robin L Gabriels; Fiscal Year: 2013
    ..aims to expand on our pilot study findings of significant improvements in self-regulation, communication, and motor skills for ASD participants involved in 10-weeks of therapeutic horseback riding compared to a 10-week waitlist ..
  53. Motor Skill Learning in Autism
    Stewart H Mostofsky; Fiscal Year: 2012
    ..Our studies led to a critical observation: there is a fundamental difference in how children with autism learn motor skills: they build a stronger than normal association between motor commands and intrinsic proprioceptive feedback and ..
  54. Cognitive Neurorehabilitation to Enhance Recovery After Stroke
    DeAnna L Adkins; Fiscal Year: 2010
    ..However, basic neurobiology research suggests that the neural basis of motor skills acquisition and performance is different from cognitive tasks such as episodic memory...
  55. Wireless EEG System for Training Attention and Eye Movement in ASD
    Jeanne Townsend; Fiscal Year: 2013
    ..develop over the first two post- natal years and are preceded by subtle but abnormal visual attention and motor skills. Trainings to improve social interaction and communication are the most common of behavioral interventions in ..
  56. Regulation of Force in Children with Prenatal Exposure to Alcohol
    ROGER WILLIAM SIMMONS; Fiscal Year: 2010
    ..problems including deficits in intellectual functioning, language development, attention, learning, memory, and motor skills. With regard to motor skills, we have previously assessed balance, reaction time, anticipation time, and ..
  57. Robot child interactions as an intervention tool for children with autism
    ANJANA NARAYAN BHAT; Fiscal Year: 2010
    ..will examine the efficacy of robot child interactions for enhancing social, communication, and perceptuo-motor skills of children with high and low functioning ASD...
  58. Involvement of motor cortex in the acquisition and production of motor sequences
    Risa Kawai; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Much of our behavioral repertoire consists of learned motor skills, yet little is known about the neural mechanisms underlying their acquisition and production...
  59. Motor Planning in Children with Cerebral Palsy
    MAX KURZ; Fiscal Year: 2013
    ..of developing innovative treatment strategies that can maximize the ability of children with CP to learn new motor skills. To meet this goal, we have implemented an innovative approach that that uses magnetoencephalography (MEG) ..
  60. Behavioral and Neural Analysis of vocal Plasticity
    Michael S Brainard; Fiscal Year: 2013
    ..model for studying how performance-based feedback is used by the nervous system in calibrating and maintaining motor skills, with particular relevance to human speech...
  61. Robot child interactions as an intervention tool for children with autism
    ANJANA NARAYAN BHAT; Fiscal Year: 2012
    ..will examine the efficacy of robot child interactions for enhancing social, communication, and perceptuo-motor skills of children with high and low functioning ASD...
  62. Sensorimotor learning of facial expressions: A novel intervention for autism
    Marian Stewart Bartlett; Fiscal Year: 2010
    ..The project will also contribute to the understanding of the development and learning of motor skills essential to social functioning...
  63. Cell Biological Determinants of Jaw Size
    JENNIFER LESLIE FISH; Fiscal Year: 2013
    ..Proper establishment of jaw length is essential to feeding, breathing, and normal development of oral-motor skills. Micrognathia, also referred to as mandibular hypoplasia, is a condition where the jaw is undersized...
  64. MOTOR TRAINING FOR FALL PREVENTION: ADAPTATION AND RETENTION IN OLDER ADULTS
    YI CHUNG CLIVE PAI; Fiscal Year: 2012
    ..Furthermore, we have demonstrated that these improved motor skills acquired from a single session can be retained for at least 4-6 months upon re-testing, making such ..
  65. VA Low Vision Intervention Trial (LOVIT) II
    Joan Stelmack; Fiscal Year: 2009
    ..will compare the mean changes in other visual ability measures (mobility, visual information processing, visual motor skills and overall visual ability) in the treatment and control groups using t-tests for independent groups with ..
  66. Motor Learning in Parkinson's Disease
    M Ghilardi; Fiscal Year: 2002
    ..In this longitudinal study, we will also evaluate changes in acquisition of motor skills other than sequence learning, such as adaptation to new reference frames or novel inertial configuration...
  67. CANNABIS PHARMACOKINETICS: RELATION TO HUMAN PERFORMANCE
    BARBARA MANNO; Fiscal Year: 1992
    ..Pursuit tracking will be assessed using the Pursuit Meter II which is a task related perceptual motor skills testing device similar to those used in operating vehicles and other commonly encountered work and recreational ..
  68. Novel MRS Methods to Characterize MCMD
    Karl Goodkin; Fiscal Year: 2007
    ..speed, working memory, episodic memory, visuoconstructive skills, abstraction/executive function, language, and motor skills. Support of this study would lead to a subsequent larger, longitudinal R01 proposal aimed at further ..
  69. Ethanol and the Developing Cerebellum
    Dwight Pierce; Fiscal Year: 2009
    ..the early third trimester and results in loss of Purkinje neurons of the cerebellum and functional deficits in motor skills and eye blink conditioning. Similar impairments are seen in human FASD...
  70. Sympathetic Nerve Activity and Fine Motor Skills
    Minoru Shinohara; Fiscal Year: 2007
    ..whether enhanced activity of the sympathetic nervous system impairs the ability of individuals to perform fine motor skills. The proposed research represents a novel study that will investigate an unexplored functional connection ..
  71. Cognitive Representation in Specific Language Impairment
    Julia L Evans; Fiscal Year: 2010
    ..Procedural memory is used in the learning of sequential, cognitive, and perceptual motor skills. Recent work suggests, however, that SLI may instead be a domain general implicit learning impairment that ..
  72. fMRI of Hippocampal Function in Cannabis Users
    JENNIFER SNEIDER; Fiscal Year: 2007
    ..It has been shown that cannabis affects memory, frontal and executive function, decision-making and motor skills. However, previous studies have not systematically assessed hippocampal spatial processing...
  73. Aging, Brain Cytokines and HIV-Associated Dementia
    Rodney Johnson; Fiscal Year: 2007
    ..In the first aim, learning, memory, and motor skills in adult and aged mice will be assessed and oxidative stress and several inflammatory cytokines will be ..