motor skills

Summary

Summary: Performance of complex motor acts.

Top Publications

  1. ncbi Daytime sleep condenses the time course of motor memory consolidation
    Maria Korman
    Brain Behavior Research Center, University of Haifa, Mount Carmel, Haifa 31905, Israel
    Nat Neurosci 10:1206-13. 2007
  2. ncbi Implicit motor learning in surgery: implications for multi-tasking
    R S W Masters
    Institute of Human Performance, The University of Hong Kong, Hong Kong SAR, China
    Surgery 143:140-5. 2008
  3. doi Tactile feedback and timing accuracy in piano performance
    Werner Goebl
    Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada
    Exp Brain Res 186:471-9. 2008
  4. ncbi Impairment of retention but not acquisition of a visuomotor skill through time-dependent disruption of primary motor cortex
    Arash Hadipour-Niktarash
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 27:13413-9. 2007
  5. ncbi Off-line processing: reciprocal interactions between declarative and procedural memories
    Rachel M Brown
    Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 27:10468-75. 2007
  6. ncbi Practice with sleep makes perfect: sleep-dependent motor skill learning
    Matthew P Walker
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Neuron 35:205-11. 2002
  7. ncbi Action observation and acquired motor skills: an FMRI study with expert dancers
    B Calvo-Merino
    Institute of Movement Neuroscience, University College London and Department of Basic Psychology, Faculty of Psychology, Universidad Complutense, Madrid, Spain
    Cereb Cortex 15:1243-9. 2005
  8. ncbi Distinct contribution of the cortico-striatal and cortico-cerebellar systems to motor skill learning
    Julien Doyon
    Department of Psychology, University of Montreal, PO Box 6128, Downtown Station, Montreal, Que, Canada H3C3J7
    Neuropsychologia 41:252-62. 2003
  9. ncbi The musician's brain as a model of neuroplasticity
    Thomas F Münte
    Department of Neuropsychology, Otto von Guericke University, Universitatsplatz 2, Gebäude 24, 39106 Magdeburg, Germany
    Nat Rev Neurosci 3:473-8. 2002
  10. ncbi Bayesian integration in sensorimotor learning
    Konrad P Kording
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nature 427:244-7. 2004

Research Grants

  1. RANDOMIZED INDOMETHACIN GMH/IVH PREVENTION TRIAL
    Laura Ment; Fiscal Year: 1999
  2. Neuroprotection with serpins during cardiac surgery
    Richard A Jonas; Fiscal Year: 2010
  3. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    Donald G Phinney; Fiscal Year: 2010
  4. ADAPTIVE PLASTICITY IN THE SPINAL STRETCH REFLEX
    JONATHAN RICKEL WOLPAW; Fiscal Year: 2010
  5. Childhood Leukemia: Oxidative Stress, Cognitive Changes & Academic Outcomes
    IDA MARIE MOORE; Fiscal Year: 2010
  6. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
  7. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
  8. Spinal Reflex Conditioning and Locomotion
    JONATHAN RICKEL contact WOLPAW; Fiscal Year: 2010
  9. Spinal Reflex Conditioning and Locomotion
    JONATHAN WOLPAW; Fiscal Year: 2009
  10. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2006

Detail Information

Publications322 found, 100 shown here

  1. ncbi Daytime sleep condenses the time course of motor memory consolidation
    Maria Korman
    Brain Behavior Research Center, University of Haifa, Mount Carmel, Haifa 31905, Israel
    Nat Neurosci 10:1206-13. 2007
    ..These results suggest that the evolution of robustness to interference and the evolution of delayed gains can coincide immediately post-training and that both effects reflect sleep-sensitive processes...
  2. ncbi Implicit motor learning in surgery: implications for multi-tasking
    R S W Masters
    Institute of Human Performance, The University of Hong Kong, Hong Kong SAR, China
    Surgery 143:140-5. 2008
    Implicitly learned motor skills are characterized by minimal conscious knowledge of the movements involved and stable performance despite stress, fatigue, or multi-tasking...
  3. doi Tactile feedback and timing accuracy in piano performance
    Werner Goebl
    Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, QC, H3A 1B1, Canada
    Exp Brain Res 186:471-9. 2008
    ..These findings suggest that sensory information available at finger-key contact enhances the timing accuracy of finger movements in piano performance...
  4. ncbi Impairment of retention but not acquisition of a visuomotor skill through time-dependent disruption of primary motor cortex
    Arash Hadipour-Niktarash
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 27:13413-9. 2007
    ..This processing in M1 may represent a slow component of motor memory which plays a significant role in retention...
  5. ncbi Off-line processing: reciprocal interactions between declarative and procedural memories
    Rachel M Brown
    Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 27:10468-75. 2007
    ..These results challenge the concept of fixed independent memory systems; instead, they suggest a dynamic relationship, modulated by when consolidation takes place, allowing at times for a reciprocal interaction between memory systems...
  6. ncbi Practice with sleep makes perfect: sleep-dependent motor skill learning
    Matthew P Walker
    Laboratory of Neurophysiology, Department of Psychiatry, Harvard Medical School, 74 Fenwood Road, Boston, Massachusetts 02115, USA
    Neuron 35:205-11. 2002
    ..This finding of sleep-dependent motor skill improvement may have important implications for the efficient learning of all skilled actions in humans...
  7. ncbi Action observation and acquired motor skills: an FMRI study with expert dancers
    B Calvo-Merino
    Institute of Movement Neuroscience, University College London and Department of Basic Psychology, Faculty of Psychology, Universidad Complutense, Madrid, Spain
    Cereb Cortex 15:1243-9. 2005
    When we observe someone performing an action, do our brains simulate making that action? Acquired motor skills offer a unique way to test this question, since people differ widely in the actions they have learned to perform...
  8. ncbi Distinct contribution of the cortico-striatal and cortico-cerebellar systems to motor skill learning
    Julien Doyon
    Department of Psychology, University of Montreal, PO Box 6128, Downtown Station, Montreal, Que, Canada H3C3J7
    Neuropsychologia 41:252-62. 2003
    ..e. automatization) when subjects achieve asymptotic performance, as well as during reactivation of the new skilled behavior in the retention phase...
  9. ncbi The musician's brain as a model of neuroplasticity
    Thomas F Münte
    Department of Neuropsychology, Otto von Guericke University, Universitatsplatz 2, Gebäude 24, 39106 Magdeburg, Germany
    Nat Rev Neurosci 3:473-8. 2002
    ..Here, we focus on the functional and anatomical differences that have been detected in musicians by modern neuroimaging methods...
  10. ncbi Bayesian integration in sensorimotor learning
    Konrad P Kording
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nature 427:244-7. 2004
    ..The central nervous system therefore employs probabilistic models during sensorimotor learning...
  11. ncbi Reorganization and plasticity in the adult brain during learning of motor skills
    Julien Doyon
    Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen Mary Street, Montreal, Quebec, H3W 1W5, Canada
    Curr Opin Neurobiol 15:161-7. 2005
    ..There has been recent behavioral, lesion and additional neuroimaging studies that have addressed the assumptions made in this theory that will help in the revision of this model...
  12. ncbi Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct
    R J Nudo
    Department of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, 77030, USA
    Science 272:1791-4. 1996
    ....
  13. pmc Interacting adaptive processes with different timescales underlie short-term motor learning
    Maurice A Smith
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 4:e179. 2006
    ..Our results suggest that motor adaptation depends on at least two distinct neural systems that have different sensitivity to error and retain information at different rates...
  14. pmc Motor adaptation as a process of reoptimization
    Jun Izawa
    Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 28:2883-91. 2008
    ..Through reward-based optimization, we use the internal model to search for a better movement plan to minimize implicit motor costs and maximize rewards...
  15. pmc Sleep and the time course of motor skill learning
    Matthew P Walker
    Massachusetts Mental Health Center, Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA
    Learn Mem 10:275-84. 2003
    ..Finally, whereas the majority of sleep-dependent motor-skill learning develops during the first night of sleep following training, additional nights of sleep still offer continued improvements...
  16. ncbi Central mechanisms of motor skill learning
    Okihide Hikosaka
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Building 49, Room 2A50, Bethesda, Maryland 20892, USA
    Curr Opin Neurobiol 12:217-22. 2002
    ..This architecture accounts for the seemingly diverse features of motor learning...
  17. pmc Experience-dependent changes in cerebellar contributions to motor sequence learning
    Julien Doyon
    Department of Psychology, University of Montreal, Montreal, QC, Canada H3C 3J7
    Proc Natl Acad Sci U S A 99:1017-22. 2002
    ....
  18. ncbi An interference effect of observed biological movement on action
    J M Kilner
    Institut des Sciences Cognitives, 67 Boulevard Pinel, Bron 69675, France
    Curr Biol 13:522-5. 2003
    ..These results suggest that the simultaneous activation of the overlapping neural networks that process movement observation and execution infers a measurable cost to motor control...
  19. doi Fundamental movement skills in children and adolescents: review of associated health benefits
    David R Lubans
    School of Education, University of Newcastle, Callaghan Campus, Newcastle, New South Wales, Australia
    Sports Med 40:1019-35. 2010
    ..More longitudinal and intervention research examining the relationship between FMS competency and potential psychological, physiological and behavioural outcomes in children and adolescents is recommended...
  20. pmc Contribution of night and day sleep vs. simple passage of time to the consolidation of motor sequence and visuomotor adaptation learning
    Julien Doyon
    Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565 Queen Mary, Montreal, QC H3W 1W5, Canada
    Exp Brain Res 195:15-26. 2009
    There is increasing evidence supporting the notion that the contribution of sleep to consolidation of motor skills depends on the nature of the task used in practice...
  21. doi Contributions of the basal ganglia and functionally related brain structures to motor learning
    Julien Doyon
    Functional Neuroimaging Unit, University of Montreal Geriatric Institute, Montreal, Quebec, Canada
    Behav Brain Res 199:61-75. 2009
    ..These results are then put into a plausible neurobiological model of motor skill learning, which proposes an integrated view of the brain plasticity mediating this form of memory at different stages of the acquisition process...
  22. pmc Neural correlates of outcome after stroke: a cross-sectional fMRI study
    N S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 126:1430-48. 2003
    ..These results further our understanding of the recovery process by demonstrating for the first time a clear relationship between task-related activation of the motor system and outcome after stroke...
  23. ncbi An implicit plan overrides an explicit strategy during visuomotor adaptation
    Pietro Mazzoni
    Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 26:3642-5. 2006
    ..This suggests that the motor system requires that planned and executed trajectories remain congruous in visual space, and enforces this correspondence even at the expense of an opposing explicit task goal...
  24. ncbi The neural correlates of motor skill automaticity
    Russell A Poldrack
    Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095 1563, USA
    J Neurosci 25:5356-64. 2005
    ....
  25. ncbi Motor control strategies revealed in the structure of motor variability
    Mark L Latash
    Department of Kinesiology, Pennsylvania State University, University Park 16802, USA
    Exerc Sport Sci Rev 30:26-31. 2002
    ..The hypothesis and associated computational apparatus have great potential for application in the areas of motor rehabilitation and motor skill acquisiton...
  26. doi Functional neuroanatomical networks associated with expertise in motor imagery
    Aymeric Guillot
    CRIS, Performance Motrice, Mentale et du Matériel P3M, Universite de Lyon, Universite Claude Bernard Lyon I, 27 29 Boulevard du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
    Neuroimage 41:1471-83. 2008
    ..225-238], our results demonstrate that compared to skilled imagers, poor imagers not only need to recruit the cortico-striatal system, but to compensate with the cortico-cerebellar system during MI of sequential movements...
  27. ncbi Motor sequence learning with the nondominant left hand. A PET functional imaging study
    Scott T Grafton
    Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, 6162 Moore Hall, Dartmouth College, Hanover, NH 03755, USA
    Exp Brain Res 146:369-78. 2002
    ..Mirror transformation of the sequence by the right hand was associated with a marked increase in regional activity in the left motor cortex, consistent with a role for sequential transformation at this level of the motor output pathway...
  28. doi Encoding of motor skill in the corticomuscular system of musicians
    Reinhard Gentner
    Human Cortical Physiology and Motor Control Laboratory, Department of Neurology, University of Wuerzburg, Josef Schneider Strasse 11, Wuerzburg, Germany
    Curr Biol 20:1869-74. 2010
    How motor skills are stored in the nervous system represents a fundamental question in neuroscience...
  29. ncbi Infant and toddler oral- and manual-motor skills predict later speech fluency in autism
    Morton Ann Gernsbacher
    University of Wisconsin Madison, USA
    J Child Psychol Psychiatry 49:43-50. 2008
    ..Spoken and gestural communication proficiency varies greatly among autistic individuals. Three studies examined the role of oral- and manual-motor skill in predicting autistic children's speech development...
  30. ncbi Awareness modifies the skill-learning benefits of sleep
    Edwin M Robertson
    Laboratory for Magnetic Brain Stimulation, Behavioral Neurology Unit, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Biol 14:208-12. 2004
    ..These results show a behavioral dissociation, based upon an individual's awareness for having learned a sequence of finger movements. Offline learning is sleep dependent for explicit skills but time dependent for implicit skills...
  31. ncbi Early consolidation in human primary motor cortex
    Wolf Muellbacher
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 10, Rm 5N226, 10 Center Drive MSC 1428, Bethesda, Maryland 20892 1428, USA
    Nature 415:640-4. 2002
    ..These findings indicate that the human M1 is specifically engaged during the early stage of motor consolidation...
  32. pmc Brain plasticity related to the consolidation of motor sequence learning and motor adaptation
    Karen Debas
    Functional Neuroimaging Unit, Centre de Recherche de l Institut Gériatrique, Universite de Montreal, Montreal, QC, Canada H3W 1W5
    Proc Natl Acad Sci U S A 107:17839-44. 2010
    ..through functional MRI (fMRI), the neuronal substrates associated with the consolidation process of two motor skills: motor sequence learning (MSL) and motor adaptation (MA)...
  33. ncbi Repetitive transcranial magnetic stimulation-induced corticomotor excitability and associated motor skill acquisition in chronic stroke
    Yun Hee Kim
    Department of Physical Therapy, Graduate School of Rehabilitation Therapy, Yonsei University, Wonju City, Kangwon do corrected Republic of Korea
    Stroke 37:1471-6. 2006
    ..This study investigated high-frequency rTMS-induced cortical excitability and the associated motor skill acquisition in chronic stroke patients...
  34. ncbi Fundamental movement skills and habitual physical activity in young children
    Abigail Fisher
    University of Glasgow Division of Developmental Medicine, Yorkhill Hospitals, Glasgow, Scotland
    Med Sci Sports Exerc 37:684-8. 2005
    ..To test for relationships between objectively measured habitual physical activity and fundamental movement skills in a relatively large and representative sample of preschool children...
  35. pmc Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits
    Matthias Groszer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Curr Biol 18:354-62. 2008
    ....
  36. ncbi Fine modulation in network activation during motor execution and motor imagery
    Ana Solodkin
    Department of Neurology and Brain Research Imaging Center, The University of Chicago, Chicago, IL 60637, USA
    Cereb Cortex 14:1246-55. 2004
    ..Finally, this study highlights the role of the connection of superior parietal lobule to the supplementary motor area in both types of motor imagery...
  37. pmc Dual adaptation supports a parallel architecture of motor memory
    Jeong Yoon Lee
    Department of Computer Science and Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90089, USA
    J Neurosci 29:10396-404. 2009
    ..Our result suggests that during motor adaptation, fast and slow processes are updated simultaneously from the same motor learning errors...
  38. ncbi Hemispheric differences in the relationship between corticomotor excitability changes following a fine-motor task and motor learning
    Michael I Garry
    Discipline of Physiology, School of Molecular and Biomedical Science, The University of Adelaide, Adelaide SA 5005, Australia
    J Neurophysiol 91:1570-8. 2004
    ..This asymmetry may reflect different behavioral strategies for performance improvement with left and right upper limb in this task or hemispheric differences in the control of skilled hand movements...
  39. ncbi A neuropsychological theory of motor skill learning
    D B Willingham
    Department of Psychology, University of Virginia, Charlottesville 22903 USA
    Psychol Rev 105:558-84. 1998
    ..It also makes a number of predictions about the purely cognitive, including accounts of mental practice, the representation of motor skill, and the interaction of conscious and unconscious processes in motor skill learning...
  40. ncbi Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats
    T A Jones
    Department of Psychology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 19:10153-63. 1999
    ..experience effects on synaptic plasticity after brain damage, the present study examined the effects of complex motor skills training (the acrobatic task) on synaptic changes in layer V of the motor cortex opposite unilateral damage to ..
  41. pmc Dopamine in motor cortex is necessary for skill learning and synaptic plasticity
    Katiuska Molina-Luna
    Clinical Neurorehabilitation, Department of Neurology, University of Zurich, Zurich, Switzerland
    PLoS ONE 4:e7082. 2009
    Preliminary evidence indicates that dopamine given by mouth facilitates the learning of motor skills and improves the recovery of movement after stroke. The mechanism of these phenomena is unknown...
  42. pmc Learning optimal adaptation strategies in unpredictable motor tasks
    Daniel A Braun
    Bernstein Center for Computational Neuroscience, Albert Ludwig University, 79104 Freiburg, Germany
    J Neurosci 29:6472-8. 2009
    ..These results suggest that adaptation can become specifically tuned to identify task-specific parameters in an optimal manner...
  43. doi Bimanual coordination and corpus callosum microstructure in young adults with traumatic brain injury: a diffusion tensor imaging study
    Karen Caeyenberghs
    Motor Control Laboratory, Research Center for Movement Control and Neuroplasticity, K U Leuven, Belgium
    J Neurotrauma 28:897-913. 2011
    ..This study provides evidence that structural alterations of several subregional callosal fibers in adults with TBI are associated with differential behavioral manifestations of bimanual motor functioning...
  44. doi Two classes of movements in motor control
    Elizabeth B Torres
    Psychology Department Busch Campus, Rutgers University, 152 Frelinghuysen Rd, Piscataway, NJ 08854, USA
    Exp Brain Res 215:269-83. 2011
    ....
  45. ncbi Motor and gestural performance in children with autism spectrum disorders, developmental coordination disorder, and/or attention deficit hyperactivity disorder
    Deborah Dewey
    Department of Pediatrics, University of Calgary, Alberta, Canada
    J Int Neuropsychol Soc 13:246-56. 2007
    ..b>Motor skills were assessed with the Bruininks-Oseretsky Test of Motor Proficiency Short Form, and gestural skills were ..
  46. ncbi Sleep-dependent motor memory plasticity in the human brain
    M P Walker
    Sleep and Neuroimaging Laboratory, FD Feldberg 862, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Neuroscience 133:911-7. 2005
    ..This evidence of an overnight, systems-level change in the representation of a motor memory holds important implications for acquiring real-life skills and in clinical rehabilitation following brain trauma, such as stroke...
  47. doi Motor development in very preterm and very low-birth-weight children from birth to adolescence: a meta-analysis
    Jorrit F de Kieviet
    Department of Clinical Neuropsychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    JAMA 302:2235-42. 2009
    ..There is increasing evidence that very preterm birth and VLBW have a considerable effect on motor development, although findings are inconsistent...
  48. doi Obesity and skill attainment in early childhood
    John Cawley
    Department of Policy Analysis and Management, Cornell University, Ithaca, NY 14853, USA
    Econ Hum Biol 6:388-97. 2008
    ..estimate models of developmental functioning in four critical areas (verbal skills, activities of daily living, motor skills, and social skills) as a function of various measures of weight (including body mass index and obesity) ..
  49. doi Motor skills in children aged 7-10 years, diagnosed with autism spectrum disorder
    Caroline P Whyatt
    School of Psychology, Queen s University Belfast, 18 30 Malone Road, Belfast, BT9 5BN, Northern Ireland, UK
    J Autism Dev Disord 42:1799-809. 2012
    This study used the Movement Assessment Battery for Children (M-ABC2) to assess motor skills in children aged 7-10 years with autism (n = 18) in comparison to two groups of age-matched typically developing children; a receptive ..
  50. doi Task-specific training: evidence for and translation to clinical practice
    Isobel J Hubbard
    Acute Stroke Unit, John Hunter Hospital, Hunter New England Area Health Service, Newcastle, and The University of Newcastle, Newcastle, Australia
    Occup Ther Int 16:175-89. 2009
    ....
  51. pmc Mechanisms controlling motor output to a transfer hand after learning a sequential pinch force skill with the opposite hand
    Mickael Camus
    Human Cortical Physiology and Stroke Neurorehabilitation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20817, USA
    Clin Neurophysiol 120:1859-65. 2009
    ..We hypothesized that intermanual transfer of learning such a task would reveal intracortical changes within M1...
  52. doi Repeated mesenchymal stem cell treatment after neonatal hypoxia-ischemia has distinct effects on formation and maturation of new neurons and oligodendrocytes leading to restoration of damage, corticospinal motor tract activity, and sensorimotor function
    Cindy T J van Velthoven
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands
    J Neurosci 30:9603-11. 2010
    ..We propose that the function of MSCs is dictated by adaptive specific signals provided by the damaged and regenerating brain...
  53. pmc Implicit sequence-specific motor learning after subcortical stroke is associated with increased prefrontal brain activations: an fMRI study
    Sean K Meehan
    Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada
    Hum Brain Mapp 32:290-303. 2011
    ..This study is the first to highlight the importance of the prefrontal cortex for implicit sequence-specific motor learning after stroke...
  54. ncbi Enhanced cortical activation in the contralesional hemisphere of chronic stroke patients in response to motor skill challenge
    Judith D Schaechter
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Cereb Cortex 18:638-47. 2008
    ..The findings of the current study suggest that successful recovery of motor skill after hemiparetic stroke involves participation of the contralesional cortical network...
  55. doi Developmental coordination disorder and other motor control problems in girls with autism spectrum disorder and/or attention-deficit/hyperactivity disorder
    Svenny Kopp
    Goteborg University, Institute of Neuroscience and Physiology, Sweden
    Res Dev Disabil 31:350-61. 2010
    ..Their motor problems contribute to reduced activity in daily life even when the effects of IQ have been partialled out...
  56. ncbi Motor improvements after focal cortical ischemia in adult rats are mediated by compensatory mechanisms
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 162:71-82. 2005
    ..The finding that reaching success was not related to lesion size supports the idea that the degree of adaptive behavior after cortical ischemia depends on plastic properties of the remaining intact tissue...
  57. doi The effect of amblyopia on fine motor skills in children
    Ann L Webber
    School of Optometry and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    Invest Ophthalmol Vis Sci 49:594-603. 2008
    In an investigation of the functional impact of amblyopia in children, the fine motor skills of amblyopes and age-matched control subjects were compared...
  58. ncbi Instructional climates in preschool children who are at-risk. Part I: object-control skill development
    Leah E Robinson
    Department of Kinesiology, Auburn University, Auburn, AL 36849 5323, USA
    Res Q Exerc Sport 80:533-42. 2009
    ..The authors conclude that developmentally and instructionally appropriate climates are beneficial to OC skill learning, along with the need for "planned" movement experiences in motor learning environments...
  59. pmc Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill
    Henry H Yin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, 5625 Fishers Lane, MSC 9411, Bethesda, Maryland 20852 9411, USA
    Nat Neurosci 12:333-41. 2009
    ..These findings demonstrate that region- and pathway-specific plasticity sculpts the circuits involved in the performance of the skill as it becomes automatized...
  60. doi Motor learning in children: feedback effects on skill acquisition
    Katherine J Sullivan
    Division of Biokinesiology and Physical Therapy at the School of Dentistry, University of Southern California, 1540 E Alcazar St, CHP 155, Los Angeles, CA 90089 9006, USA
    Phys Ther 88:720-32. 2008
    ..The purpose of this study was to determine the effect of different relative frequencies of feedback on skill acquisition in children compared with young adults...
  61. doi Neural substrates of motor memory consolidation depend on practice structure
    Shailesh S Kantak
    Motor Behavior and Neurorehabilitation Laboratory, Division of Biokinesiology and Physical Therapy at the Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California, USA
    Nat Neurosci 13:923-5. 2010
    ..We conclude that neural substrates of motor-memory consolidation are modulated by practice structure...
  62. pmc Sleep-dependent learning and motor-skill complexity
    Kenichi Kuriyama
    Center for Sleep and Cognition, Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Learn Mem 11:705-13. 2004
    ..4% improvement. Together, these findings suggest that the sleep-dependent learning process selectively provides maximum benefit to motor-skill procedures that proved to be most difficult prior to sleep...
  63. ncbi Long-term training affects cerebellar processing in skilled keyboard players
    Susan Koeneke
    Department of Neuropsychology, University of Zurich, Treichlerstrasse 10, CH 8032 Zurich, Switzerland
    Neuroreport 15:1279-82. 2004
    ..For the same movements fewer neurons need to be recruited. The different volume of the activated cortical areas might therefore reflect the different effort necessary for motor performance in both groups...
  64. doi The impact of stroke on the performance of grasping: usefulness of kinetic and kinematic motion analysis
    Dennis A Nowak
    Department of Neurology, University of Cologne, Cologne, Germany
    Neurosci Biobehav Rev 32:1439-50. 2008
    ....
  65. pmc Motor sequence learning increases sleep spindles and fast frequencies in post-training sleep
    Amelie Morin
    Centre d Etude du Sommeil et des Rythmes Biologiques, Laboratoire de chronobiologie, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    Sleep 31:1149-56. 2008
    ..To investigate polysomnographic (PSG) sleep and NREM sleep characteristics, including sleep spindles and spectral activity involved in offline consolidation of a motor sequence learning task...
  66. ncbi Improvement of dexterity by single session low-frequency repetitive transcranial magnetic stimulation over the contralesional motor cortex in acute stroke: a double-blind placebo-controlled crossover trial
    Joachim Liepert
    Department of Neurology, University Hospital, Freiburg, Germany
    Restor Neurol Neurosci 25:461-5. 2007
    ..We investigated if inhibitory 1~Hz repetitive transcranial magnetic stimulation (rTMS) over the contralesional M1 improved motor performance of the affected hand in acute stroke...
  67. ncbi Limited transfer of learning between unimanual and bimanual skills within the same limb
    Daichi Nozaki
    Centre for Neuroscience Studies, Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Nat Neurosci 9:1364-6. 2006
    ..These results suggest partial, but not complete, overlap in the learning processes involved in the acquisition of unimanual and bimanual skills...
  68. doi Dopaminergic projections from midbrain to primary motor cortex mediate motor skill learning
    Jonas A Hosp
    Clinical Neurorehabilitation, Department of Neurology, University of Zurich, CH 8091 Zurich, Switzerland
    J Neurosci 31:2481-7. 2011
    ..Because VTA dopaminergic neurons are known to signal rewards, the VTA-to-M1 projection is a candidate for relaying reward information that could directly support the encoding of a motor skill within M1...
  69. ncbi Coarticulation in fluent fingerspelling
    Thomas E Jerde
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 23:2383-93. 2003
    ..The simultaneous occurrence of dissimilation in some joints and assimilation in others demonstrates an unprecedented level of parallel control of individual joint rotations in an essentially serial task...
  70. pmc Motor control and aging: links to age-related brain structural, functional, and biochemical effects
    Rachael D Seidler
    School of Kinesiology, University of Michigan, 401 Washtenaw Avenue, Ann Arbor, MI 48109 2214, USA
    Neurosci Biobehav Rev 34:721-33. 2010
    ..Existing exercise, pharmaceutical, and motor training interventions may ameliorate motor deficits in older adults...
  71. pmc Optimal control predicts human performance on objects with internal degrees of freedom
    Arne J Nagengast
    Department of Engineering, Computational and Biological Learning Lab, University of Cambridge, Cambridge, United Kingdom
    PLoS Comput Biol 5:e1000419. 2009
    ..A class of tasks, which can pose a serious challenge to our motor skills, are those that involve manipulating objects with internal degrees of freedom, such as when folding laundry or ..
  72. doi Inside the brain of an elite athlete: the neural processes that support high achievement in sports
    Kielan Yarrow
    Department of Psychology, City University London, Northampton Square, London, EC1V OHB, UK
    Nat Rev Neurosci 10:585-96. 2009
    ..In this way we hope to inspire neuroscientists to consider how their basic research might help to explain sporting skill at the highest levels of performance...
  73. ncbi Mental practice in chronic stroke: results of a randomized, placebo-controlled trial
    Stephen J Page
    Department of Physical Medicine and Rehabilitation, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0530
    Stroke 38:1293-7. 2007
    ..Pilot study results suggest that a rehabilitation program incorporating MP of valued motor skills in chronic stroke patients provides sufficient repetitive practice to increase affected arm use and function...
  74. ncbi Dual task interference during gait in people with Parkinson disease: effects of motor versus cognitive secondary tasks
    Simone O'Shea
    Wodonga Regional Health Service, Wodonga, Victoria, Australia
    Phys Ther 82:888-97. 2002
    ..The aim of this investigation was to identify whether the type of secondary task (motor or cognitive) determined the severity of dual task interference...
  75. ncbi Parallel evolution of cortical areas involved in skilled hand use
    Jeffrey Padberg
    Center for Neuroscience, University of California, Davis, California 95618, USA
    J Neurosci 27:10106-15. 2007
    ....
  76. doi The what and how of observational learning
    Sara Torriero
    Laboratorio di Neurologia Clinica e Comportamentale, IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00178 Rome, Italy
    J Cogn Neurosci 19:1656-63. 2007
    ....
  77. doi Role of the primary somatosensory cortex in motor learning: An rTMS study
    E D Vidoni
    Department of Neurology, University of Kansas Medical Centre, Kansas City, KS, USA
    Neurobiol Learn Mem 93:532-9. 2010
    ..The current study shows that disruption of somatosensation during task practice impairs the magnitude of change associated with motor learning, perhaps through the development of an inaccurate internal model...
  78. doi A study on fine motor skills of Iranian children with attention deficit/hyper activity disorder aged from 6 to 11 years
    Negar Miri Lavasani
    School of Health and Social Development, Deakin University, Geelong, Victoria 3217, Australia
    Occup Ther Int 18:106-14. 2011
    The aim of this study was to compare the fine motor skills of two groups of Iranian children...
  79. doi EEG activity during the verbal-cognitive stage of motor skill acquisition
    F F Zhu
    Institute of Human Performance, The University of Hong Kong, PR China
    Biol Psychol 84:221-7. 2010
    ....
  80. ncbi Neural correlates of motor memory consolidation
    R Shadmehr
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, 419 Traylor, Baltimore, MD 21205 2195, USA
    Science 277:821-5. 1997
    ....
  81. pmc Inducing motor skill improvements with a declarative task
    Rachel M Brown
    Center for Non Invasive Brain Stimulation, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Kirstein Building KS 446, Boston, Massachusetts 02215, USA
    Nat Neurosci 10:148-9. 2007
    ..We conclude that off-line memory processing relies not only on the engagement of neuroplastic mechanisms but also on the disengagement of an interaction between declarative and procedural memory systems...
  82. ncbi Neuroplasticity: changes in grey matter induced by training
    Bogdan Draganski
    Department of Neurology, University of Regensburg, Regensburg 93053, Germany
    Nature 427:311-2. 2004
  83. ncbi Changes in prefrontal cortical behaviour depend upon familiarity on a bimanual co-ordination task: an fNIRS study
    Daniel Richard Leff
    Royal Wolfson Image Computing Laboratory and Department of Biosurgery and Surgical Technology, Imperial College London, UK
    Neuroimage 39:805-13. 2008
    ..These data suggest that prefrontal processing across five knot-tying trials is influenced by the level of experience on a task. Modifications in prefrontal activation appear to confer technical performance adaptation in novices...
  84. pmc Excitatory repetitive transcranial magnetic stimulation to left dorsal premotor cortex enhances motor consolidation of new skills
    Lara A Boyd
    Department of Physical Therapy, University of British Columbia, Vancouver, Canada
    BMC Neurosci 10:72. 2009
    ..A delayed retention test assessed motor learning of repeated and random sequences of continuous movement; no rTMS was applied at retention...
  85. doi Developmental omega-3 supplementation improves motor skills in juvenile-adult rats
    Addolorata Coluccia
    Department of Pharmacology and Human Physiology, Medical School, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Int J Dev Neurosci 27:599-605. 2009
    ....
  86. ncbi Principles derived from the study of simple skills do not generalize to complex skill learning
    Gabriele Wulf
    Department of Kinesiology, University of Nevada, Las Vegas 89154 3034, USA
    Psychon Bull Rev 9:185-211. 2002
    We review research related to the learning of complex motor skills with respect to principles developed on the basis of simple skill learning...
  87. pmc Motor task variation induces structural learning
    Daniel A Braun
    Department of Engineering, University of Cambridge, UK
    Curr Biol 19:352-7. 2009
    ..These results suggest that skill generalization relies on task variation and structural learning...
  88. pmc Variability in motor learning: relocating, channeling and reducing noise
    R G Cohen
    Department of Psychology, The Pennsylvania State University, University Park, PA 16802, USA
    Exp Brain Res 193:69-83. 2009
    ..We speculate that by exploiting T-Cost and C-Cost, participants minimize the effects of inevitable intrinsic noise...
  89. ncbi The implicit benefit of learning without errors
    J P Maxwell
    University of Birmingham, UK
    Q J Exp Psychol A 54:1049-68. 2001
    ..It was concluded that the reduction of errors during learning encourages the use of implicit, unselective learning processes, which confer insusceptibility to performance breakdown under distraction...
  90. ncbi The role of the left temporal region under the cognitive motor demands of shooting in skilled marksmen
    S E Kerick
    Department of Kinesiology, University of Maryland, College Park, MD 20742, USA
    Biol Psychol 58:263-77. 2001
    ....
  91. ncbi Pilot study of functional MRI to assess cerebral activation of motor function after poststroke hemiparesis
    Y Cao
    NMR Research Center, Department of Neurology, Henry Ford Health Sciences Center, Detroit, Mich 48202 2689, USA
    Stroke 29:112-22. 1998
    ..Studies of cerebral activation of motor function after ischemic stroke may enhance our understanding of the underlying mechanisms of motor functional recovery, including the role of the noninfarcted hemisphere...
  92. ncbi Motor learning and Parkinson's disease: refinement of within-limb and between-limb coordination as a result of practice
    S P Swinnen
    Laboratory of Motor Control, Department of Kinesiology F L O K Group Biomedical Sciences, Katholieke Universiteit Leuven, Tervuurse Vest 101, 3001, Heverlee, Belgium
    Behav Brain Res 111:45-59. 2000
    ..The findings demonstrate that Parkinson patients do benefit from practice to refine their upper limb control and to alleviate their most basic motor deficits...
  93. ncbi Close interrelation of motor development and cognitive development and of the cerebellum and prefrontal cortex
    A Diamond
    Center for Developmental Cognitive Neurosciece, Eunice Kennedy Shriver Center, Waltham, MA 02452, USA
    Child Dev 71:44-56. 2000
    ....
  94. ncbi Prism adaptation in normal aging: slower adaptation rate and larger aftereffect
    J Fernandez-Ruiz
    Departamento de Fisiolog ia, Facultad de Medicina, Universidad Nacional Aut onoma de M exico, D F, C P 04510, Mexico, Mexico
    Brain Res Cogn Brain Res 9:223-6. 2000
    ..These findings suggest that the aftereffect requires the involvement of non-cognitive and cognitive processes and indicate that both adaptation and aftereffect are influenced by aging...
  95. doi Repetitive transcranial magnetic stimulation over the primary motor cortex disrupts early boost but not delayed gains in performance in motor sequence learning
    Christophe Hotermans
    Cyclotron Research Centre, University of Liege, B 4000 Liege, Belgium
    Eur J Neurosci 28:1216-21. 2008
    In humans the consolidation of recently learned motor skills is a multi-step process. We previously showed that performance on the finger-tapping task (FTT; i.e...
  96. ncbi Control of 3D limb dynamics in unconstrained overarm throws of different speeds performed by skilled baseball players
    Masaya Hirashima
    Department of Life Sciences Sports Sciences Graduate School of Arts and Sciences, University of Tokyo, 3 8 1 Komaba, Meguro ku, Tokyo 153 8902, Japan
    J Neurophysiol 97:680-91. 2007
    ..These results indicates that skilled ball throwers adopted a hierarchical control in which the proximal muscle torques created a dynamic foundation for the entire limb motion and beneficial interaction torques for distal joint rotations...
  97. ncbi Consolidation of dynamic motor learning is not disrupted by rTMS of primary motor cortex
    Pierre Baraduc
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Curr Biol 14:252-6. 2004
    b>Motor skills, once learned, are often retained over a long period of time. However, such learning first undergoes a period of consolidation after practice...
  98. doi Effective utilization of gravity during arm downswing in keystrokes by expert pianists
    S Furuya
    Graduate School of Medicine, Osaka University, Toyonaka, Osaka 5600043, Japan Research Center for Human Media, Kwansei Gakuin University, Sanda, Hyogo 6691337, Japan
    Neuroscience 164:822-31. 2009
    ..This shift would support the notion of non-muscular force utilization for improving physiological efficiency of limb movement with respect to the effective use of gravity...
  99. pmc Improvement of sensorimotor functions in old age by passive sensory stimulation
    Tobias Kalisch
    Department of Theoretical Biology, Institute for Neuroinformatics, Ruhr University Bochum, Bochum, Germany
    Clin Interv Aging 3:673-90. 2008
    ..Further optimizing of the stimulation protocol can be assumed to strengthen both the range and durability of its efficacy...
  100. ncbi Stable implicit motor processes despite aerobic locomotor fatigue
    R S W Masters
    Institute of Human Performance, The University of Hong Kong, 111 113 Pokfulam Road, Hong Kong SAR, China
    Conscious Cogn 17:335-8. 2008
    ..British Journal of Psychology, 83, 343-358.]) has shown that implicitly learned motor skills remain stable under psychological pressure and concurrent cognitive demands, and recently [Poolton, J. M...
  101. ncbi Motor sequence complexity and performing hand produce differential patterns of hemispheric lateralization
    Kathleen Y Haaland
    New Mexico Veterans Affairs Health Care System and University of New Mexico, USA
    J Cogn Neurosci 16:621-36. 2004
    ....

Research Grants97

  1. RANDOMIZED INDOMETHACIN GMH/IVH PREVENTION TRIAL
    Laura Ment; Fiscal Year: 1999
    ..C. A. We propose to serially study measures of IQ, attention, executive function, motor skills, behavior, and school readiness in our study population at both 54 and 72 mo. C. A...
  2. Neuroprotection with serpins during cardiac surgery
    Richard A Jonas; Fiscal Year: 2010
    ..Alternatively it can manifest itself as a generalized decline in cognitive and motor skills. Aprotinin, a "SERPIN" (serine protease inhibitor), reduces bleeding after cardiopulmonary bypass (CPB)...
  3. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    Donald G Phinney; Fiscal Year: 2010
    ..various periods up to 1 year post-transplantation, the health, development, behavior as well as cognitive and motor skills of each transplant recipient will be evaluated using a battery of age appropriate tests and compared to sham-..
  4. ADAPTIVE PLASTICITY IN THE SPINAL STRETCH REFLEX
    JONATHAN RICKEL WOLPAW; Fiscal Year: 2010
    Throughout life, the nervous system acquires and maintains many different motor skills. How this is accomplished is one of the central problems of neuroscience research...
  5. Childhood Leukemia: Oxidative Stress, Cognitive Changes & Academic Outcomes
    IDA MARIE MOORE; Fiscal Year: 2010
    ..stress, and are important for cognitive abilities, such as working memory, learning, visual-spatial and visual-motor skills. Oxidative stress as a mechanism of methotrexate-induced CNS injury that may lead to cognitive declines and ..
  6. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
    ..of the mechanisms of supraspinal control of spinal cord plasticity would elucidate the acquisition of motor skills and should lead to novel methods for inducing and guiding recovery of function after injury or disease...
  7. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2009
    ..of the mechanisms of supraspinal control of spinal cord plasticity would elucidate the acquisition of motor skills and should lead to novel methods for inducing and guiding recovery of function after injury or disease...
  8. Spinal Reflex Conditioning and Locomotion
    JONATHAN RICKEL contact WOLPAW; Fiscal Year: 2010
    Throughout life, the nervous system acquires and maintains many different motor skills. These skills depend on complex patterns of activity-dependent plasticity throughout the CNS, from the cortex to the spinal cord...
  9. Spinal Reflex Conditioning and Locomotion
    JONATHAN WOLPAW; Fiscal Year: 2009
    Throughout life, the nervous system acquires and maintains many different motor skills. These skills depend on complex patterns of activity-dependent plasticity throughout the CNS, from the cortex to the spinal cord...
  10. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2006
    ..Better understanding would elucidate the mechanisms of acquisition of motor skills, and could lead to novel methods for inducing, guiding, and assessing recovery of function after spinal cord ..
  11. VARIABILITY AND STABILITY IN SKILL ACQUISITION
    Dagmar Sternad; Fiscal Year: 2010
    The acquisition of perceptual-motor skills and their adaptation to changing task demands is fundamental to everyday life...
  12. Childhood After Preterm Birth: The Preschool Years
    LISA MCELANEY; Fiscal Year: 2007
    ..about the likely needs of infants and toddlers who were born preterm in areas such as cognition, visual and motor skills, speech and language, and executive function...
  13. Early-life phthalate exposure, thyroid function and child cognitive development
    ROBIN MARJORIE WHYATT; Fiscal Year: 2010
    ..with phthalate-induced reductions in thyroid function (intelligence, attention, executive function and motor skills)...
  14. Speech of Young Males with Fragile X Syndrome
    Joanne Roberts; Fiscal Year: 2007
    ..In addition, children's oral motor skills, phonological processing, and selective listening will be examined...
  15. ADAPTIVE PLASTICITY IN THE SPINAL STRETCH REFLEX
    JONATHAN WOLPAW; Fiscal Year: 2009
    Throughout life, the nervous system acquires and maintains many different motor skills. How this is accomplished is one of the central problems of neuroscience research...
  16. ADAPTIVE PLASTICITY IN THE SPINAL STRETCH REFLEX
    JONATHAN WOLPAW; Fiscal Year: 2009
    Throughout life, the nervous system acquires and maintains many different motor skills. How this is accomplished is one of the central problems of neuroscience research...
  17. Lesion and activity dependent corticospinal tract plasticity
    John H Martin; Fiscal Year: 2010
    ..strengthens CST connections, and can improve motor skills. We use a reproducible partial injury model in the adult rat, a unilateral pyramidal tract (PT) lesion, which ..
  18. Lesion and activity dependent corticospinal tract plasticity
    John H Martin; Fiscal Year: 2009
    ..strengthens CST connections, and can improve motor skills. We use a reproducible partial injury model in the adult rat, a unilateral pyramidal tract (PT) lesion, which ..
  19. DEVELOPMENT OF LOCAL CIRCUITS IN CEREBRAL CORTEX
    Asaf Keller; Fiscal Year: 1999
    ..be modified in a use- dependent fashion, following sensory-motor perturbations and during the acquisition of motor skills. The pliability of motor representation maps is particularly dramatic during the postnatal developmental period,..
  20. Motor Learning in Parkinson's Disease
    M Ghilardi; Fiscal Year: 2002
    ..In this longitudinal study, we will also evaluate changes in acquisition of motor skills other than sequence learning, such as adaptation to new reference frames or novel inertial configuration...
  21. Brain metabolism and neuroprotection in cardiopulmonary bypass
    Anna Pastuszko; Fiscal Year: 2010
    ..impaired executive function, expressive speech and language abnormalities, impaired visual-spatial and visual-motor skills, attention deficit/hyperactivity disorder, motor delays, and learning disabilities The neuropathological basis ..
  22. Brain metabolism and neuroprotection in cardiopulmonary bypass
    Anna Pastuszko; Fiscal Year: 2009
    ..impaired executive function, expressive speech and language abnormalities, impaired visual-spatial and visual-motor skills, attention deficit/hyperactivity disorder, motor delays, and learning disabilities The neuropathological basis ..
  23. Pre-Clinical Trial of MSC-Based Therapy for CNS Disease
    DONALD PHINNEY; Fiscal Year: 2007
    ..various periods up to 1 year post-transplantation, the health, development, behavior as well as cognitive and motor skills of each transplant recipient will be evaluated using a battery of age appropriate tests and compared to sham-..
  24. Childhood Leukemia: Oxidative Stress, Cognitive Changes & Academic Outcomes
    IDA MARIE MOORE; Fiscal Year: 2010
    ..stress, and are important for cognitive abilities, such as working memory, learning, visual-spatial and visual-motor skills. Oxidative stress as a mechanism of methotrexate-induced CNS injury that may lead to cognitive declines and ..
  25. Novel MRS Methods to Characterize MCMD
    Karl Goodkin; Fiscal Year: 2007
    ..speed, working memory, episodic memory, visuoconstructive skills, abstraction/executive function, language, and motor skills. Support of this study would lead to a subsequent larger, longitudinal R01 proposal aimed at further ..
  26. Effects of Estrogen on Cognition in Schizophrenia
    LEAH RUBIN; Fiscal Year: 2007
    ..that women with schizophrenia will show improvements in clinical symptoms, visual scanning, and fine motor skills and perform worse on visuospatial abilities when estrogen levels are high compared to low levels of estrogen, ..
  27. Neuroprotection with serpins during cardiac surgery
    Richard Jonas; Fiscal Year: 2007
    ..Alternatively it can manifest itself as a generalized decline in cognitive and motor skills. Aprotinin, a "SERPIN" (serine protease inhibitor), reduces bleeding after cardiopulmonary bypass (CPB)...
  28. How Do Immature Perceptual-Motor Skills Put Child Cyclists at Risk for Injury?
    Jodie M Plumert; Fiscal Year: 2010
    ..apos; ..
  29. How Do Immature Perceptual-Motor Skills Put Child Cyclists at Risk for Injury?
    JODIE PLUMERT; Fiscal Year: 2007
    ....
  30. Glucocorticoids and Apoptosis of Cerebellar Neural Progenitor Cells
    Nuri Farber; Fiscal Year: 2007
    ..glucocorticoids in addition to having developmental delays and smaller brains and bodies, have impairments in motor skills, motor coordination, and visualmotor integration...
  31. NOVEL LYSOSOMAL ENZYME DEFICIENT IN BATTEN DISEASE
    Peter Lobel; Fiscal Year: 2010
    ..Disease progression is characterized by increasingly severe seizures, loss of vision and motor skills, and dementia. Early death is inevitable, typically at 8-15 years of age...
  32. Sympathetic Nerve Activity and Fine Motor Skills
    Minoru Shinohara; Fiscal Year: 2007
    ..whether enhanced activity of the sympathetic nervous system impairs the ability of individuals to perform fine motor skills. The proposed research represents a novel study that will investigate an unexplored functional connection ..
  33. Protection of Developing White Matter during Cardiac Surgery
    Richard A Jonas; Fiscal Year: 2010
    ..of development of children following surgery for congenital heart disease have documented worse outcomes for motor skills than cognitive abilities...
  34. Cognitive Representation in Specific Language Impairment
    Julia L Evans; Fiscal Year: 2010
    ..Procedural memory is used in the learning of sequential, cognitive, and perceptual motor skills. Recent work suggests, however, that SLI may instead be a domain general implicit learning impairment that ..
  35. Cognitive Representation in Specific Language Impairment
    Julia L Evans; Fiscal Year: 2010
    ..Procedural memory is used in the learning of sequential, cognitive, and perceptual motor skills. Recent work suggests, however, that SLI may instead be a domain general implicit learning impairment that ..
  36. fMRI of Hippocampal Function in Cannabis Users
    JENNIFER SNEIDER; Fiscal Year: 2007
    ..It has been shown that cannabis affects memory, frontal and executive function, decision-making and motor skills. However, previous studies have not systematically assessed hippocampal spatial processing...
  37. Alcohol and cerebellar circuits
    CARLOS VALENZUELA; Fiscal Year: 2007
    Ethanol at concentrations greater than or qual too 0.08 g/dl significantly impairs motor skills and this effect is responsible for the majority of traffic accident-related deaths in the United States...
  38. Motor Skill Learning in Autism
    Stewart H Mostofsky; Fiscal Year: 2010
    ..Our studies led to a critical observation: there is a fundamental difference in how children with autism learn motor skills: they build a stronger than normal association between motor commands and intrinsic proprioceptive feedback and ..
  39. Aging, Brain Cytokines and HIV-Associated Dementia
    Rodney Johnson; Fiscal Year: 2007
    ..In the first aim, learning, memory, and motor skills in adult and aged mice will be assessed and oxidative stress and several inflammatory cytokines will be ..
  40. Neurobehavioral Effects of Insecticide Exposure in Pregnancy and Early Childhood
    Kimberly Yolton; Fiscal Year: 2010
    ..The study will extend follow-up of this cohort to include assessments or development, cognition, motor skills, and behaviors at ages 4, 5, and 6 in an effort to examine the effects of postnatal exposure to insecticides...
  41. Learning and adaptation of Multi-Joint Arm Movement
    FERDINANDO ALESSANDRO MUSSA IVALDI; Fiscal Year: 2010
    ..These representations are the basis for the recovery of performance without the need for relearning motor skills. Adaptive mechanisms will be investigated for the recovery of force control after a change in the mechanical ..
  42. Behavioral and Neural Analysis of vocal Plasticity
    Michael S Brainard; Fiscal Year: 2010
    ..model for studying how performance-based feedback is used by the nervous system in calibrating and maintaining motor skills, with particular relevance to human speech...
  43. Learning and adaptation of Multi-Joint Arm Movement
    Ferdinando Mussa Ivaldi; Fiscal Year: 2009
    ..These representations are the basis for the recovery of performance without the need for relearning motor skills. Adaptive mechanisms will be investigated for the recovery of force control after a change in the mechanical ..
  44. Physical Activity to Modify Sequelae and QOL in Childhood ALL: A Nursing Trial
    Cheryl Cox; Fiscal Year: 2009
    ..be tested for its effect on: 1) physical function outcomes (muscle strength, range of motion, endurance, gross motor skills), bone density and bone mineral content (135 weeks only); and 2) HRQL...
  45. Physical Activity to Modify Sequelae and QOL in Childhood ALL: A Nursing Trial
    Cheryl Lorane Cox; Fiscal Year: 2010
    ..be tested for its effect on: 1) physical function outcomes (muscle strength, range of motion, endurance, gross motor skills), bone density and bone mineral content (135 weeks only);and 2) HRQL...