space perception

Summary

Summary: The awareness of the spatial properties of objects; includes physical space.

Top Publications

  1. ncbi Place navigation impaired in rats with hippocampal lesions
    R G Morris
    Nature 297:681-3. 1982
  2. ncbi Microstructure of a spatial map in the entorhinal cortex
    Torkel Hafting
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Nature 436:801-6. 2005
  3. ncbi The human hippocampus and spatial and episodic memory
    Neil Burgess
    Institute of Cognitive Neuroscience and Department of Anatomy and Developmental Biology, University College London, 17 Queen Square, London, United Kingdom
    Neuron 35:625-41. 2002
  4. ncbi Reverse replay of behavioural sequences in hippocampal place cells during the awake state
    David J Foster
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 46 5223, Cambridge, Massachusetts 02139, USA
    Nature 440:680-3. 2006
  5. ncbi Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect
    Biyu J He
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 53:905-18. 2007
  6. ncbi Conjunctive representation of position, direction, and velocity in entorhinal cortex
    Francesca Sargolini
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 312:758-62. 2006
  7. pmc Reduction of theta rhythm dissociates grid cell spatial periodicity from directional tuning
    Mark P Brandon
    Center for Memory and Brain, Department of Psychology, Graduate Program for Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Science 332:595-9. 2011
  8. ncbi Representation of geometric borders in the entorhinal cortex
    Trygve Solstad
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 322:1865-8. 2008
  9. pmc Parahippocampal and retrosplenial contributions to human spatial navigation
    Russell A Epstein
    Department of Psychology and Center for Cognitive Neuroscience, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104 6241, USA
    Trends Cogn Sci 12:388-96. 2008
  10. ncbi Development of the spatial representation system in the rat
    Rosamund F Langston
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Medical Technical Research Center, Norwegian University of Science and Technology, Olav Kyrres gate 9, 7489 Trondheim, Norway
    Science 328:1576-80. 2010

Research Grants

  1. MULTIMODAL BASIS FOR EGOCENTRIC PERCEPTION OF SPACE
    Leonard Matin; Fiscal Year: 2004
  2. Egocentric reference frames in memory
    David Waller; Fiscal Year: 2005
  3. Cue Reliability and Depth Calibration During Space Perception
    Benjamin T Backus; Fiscal Year: 2011
  4. Psychophysical Research on Auditory/Visual Space Perception and Navigation
    PAVEL A ZAHORIK; Fiscal Year: 2013
  5. Mechanisms of Intermediate Distance Space Perception
    ZIJIANG HE; Fiscal Year: 2011
  6. Mechanisms of Intermediate Distance Space Perception
    ZIJIANG HE; Fiscal Year: 2007
  7. CORTICAL MECHANISMS OF VISUAL SPACE PERCEPTION
    ALLAN DOBBINS; Fiscal Year: 2003
  8. Molecular Mechanisms in TCR Reactivity to Self Ligands
    STEPHEN JAMESON; Fiscal Year: 2005
  9. NAVIGATING WITHOUT VISION--BASIC AND APPLIED RESEARCH
    JACK LOOMIS; Fiscal Year: 2002
  10. MOTION INFORMATION AND INFANTS' COORDINATED BEHAVIOR
    Daniel Ashmead; Fiscal Year: 1992

Detail Information

Publications291 found, 100 shown here

  1. ncbi Place navigation impaired in rats with hippocampal lesions
    R G Morris
    Nature 297:681-3. 1982
  2. ncbi Microstructure of a spatial map in the entorhinal cortex
    Torkel Hafting
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Nature 436:801-6. 2005
    ..The map is anchored to external landmarks, but persists in their absence, suggesting that grid cells may be part of a generalized, path-integration-based map of the spatial environment...
  3. ncbi The human hippocampus and spatial and episodic memory
    Neil Burgess
    Institute of Cognitive Neuroscience and Department of Anatomy and Developmental Biology, University College London, 17 Queen Square, London, United Kingdom
    Neuron 35:625-41. 2002
    ....
  4. ncbi Reverse replay of behavioural sequences in hippocampal place cells during the awake state
    David J Foster
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 46 5223, Cambridge, Massachusetts 02139, USA
    Nature 440:680-3. 2006
    ..This replay is suggestive of a role in the evaluation of event sequences in the manner of reinforcement learning models. We propose that such replay might constitute a general mechanism of learning and memory...
  5. ncbi Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect
    Biyu J He
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 53:905-18. 2007
    ..Lastly, disconnection of the white matter tracts connecting frontal and parietal cortices was associated with more severe neglect and more disrupted functional connectivity. These findings support a network view in understanding neglect...
  6. ncbi Conjunctive representation of position, direction, and velocity in entorhinal cortex
    Francesca Sargolini
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 312:758-62. 2006
    ..All cell types were modulated by running speed. The conjunction of positional, directional, and translational information in a single MEC cell type may enable grid coordinates to be updated during self-motion-based navigation...
  7. pmc Reduction of theta rhythm dissociates grid cell spatial periodicity from directional tuning
    Mark P Brandon
    Center for Memory and Brain, Department of Psychology, Graduate Program for Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Science 332:595-9. 2011
    ..This supports the hypothesis that spatial coding by grid cells requires theta oscillations, and dissociates the mechanisms underlying the generation of entorhinal grid cell periodicity and head-direction selectivity...
  8. ncbi Representation of geometric borders in the entorhinal cortex
    Trygve Solstad
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 322:1865-8. 2008
    ..Border cells may be instrumental in planning trajectories and anchoring grid fields and place fields to a geometric reference frame...
  9. pmc Parahippocampal and retrosplenial contributions to human spatial navigation
    Russell A Epstein
    Department of Psychology and Center for Cognitive Neuroscience, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104 6241, USA
    Trends Cogn Sci 12:388-96. 2008
    ..These findings are a first step towards understanding the separate components of the cortical network that mediates spatial navigation in humans...
  10. ncbi Development of the spatial representation system in the rat
    Rosamund F Langston
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Medical Technical Research Center, Norwegian University of Science and Technology, Olav Kyrres gate 9, 7489 Trondheim, Norway
    Science 328:1576-80. 2010
    ..The presence of adultlike directional signals at the onset of navigation raises the possibility that such signals are instrumental in setting up networks for place and grid representation...
  11. pmc Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts
    Dave G Mumby
    Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, H4B 1R6, Quebec, Canada
    Learn Mem 9:49-57. 2002
    ..The findings indicate that hippocampal damage impairs memory for contextual or spatial aspects of an experience, whereas memory for objects that were part of the same experience are left relatively intact...
  12. ncbi Distributed and overlapping cerebral representations of number, size, and luminance during comparative judgments
    Philippe Pinel
    INSERM Unit 562, Service Hospitalier Frederic Joliot, CEA DRM DSV, 4 Place du General Leclerc, 91401 Orsay Cedex, France
    Neuron 41:983-93. 2004
    ....
  13. pmc Patients with hippocampal amnesia cannot imagine new experiences
    Demis Hassabis
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 104:1726-31. 2007
    ..Given how closely imagined experiences match episodic memories, the absence of this function mediated by the hippocampus, may also fundamentally affect the ability to vividly re-experience the past...
  14. ncbi Independent codes for spatial and episodic memory in hippocampal neuronal ensembles
    Stefan Leutgeb
    Centre for the Biology of Memory, Medical Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 309:619-23. 2005
    ..These independent encoding schemes may enable simultaneous representation of spatial and episodic memory information...
  15. ncbi Cellular networks underlying human spatial navigation
    Arne D Ekstrom
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 425:184-8. 2003
    ..The former are present primarily in the hippocampus, and the latter in the parahippocampal region. Cells throughout the frontal and temporal lobes responded to the subjects' navigational goals and to conjunctions of place, goal and view...
  16. pmc Remembering the past and imagining the future: a neural model of spatial memory and imagery
    Patrick Byrne
    Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada
    Psychol Rev 114:340-75. 2007
    ....
  17. pmc Boundary vector cells in the subiculum of the hippocampal formation
    Colin Lever
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Neurosci 29:9771-7. 2009
    ..These cells may contribute environmental information to place cell firing, complementing path integrative information. Their relationship to other cell types, including medial entorhinal "border cells," is discussed...
  18. pmc Space and the parietal cortex
    Masud Husain
    Institute of Cognitive Neuroscience, University College, London, 17 Queen Square, London WC1N 3AR, UK
    Trends Cogn Sci 11:30-6. 2007
    ....
  19. ncbi Experience-dependent rescaling of entorhinal grids
    Caswell Barry
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
    Nat Neurosci 10:682-4. 2007
    ..Thus grid scale reflects an interaction between intrinsic, path-integrative calculation of location and learned associations to the external environment...
  20. ncbi Dissociating hippocampal subregions: double dissociation between dentate gyrus and CA1
    P E Gilbert
    Department of Psychology, University of Utah, Salt Lake City 84112, USA
    Hippocampus 11:626-36. 2001
    ..In contrast, CA1 lesions resulted in a deficit on the temporal task but not the spatial task. Results suggest that the DG supports spatial pattern separation, whereas CA1 supports temporal pattern separation...
  21. pmc Double dissociation between hippocampal and parahippocampal responses to object-background context and scene novelty
    Lorelei R Howard
    Research Department of Cognitive, Perceptual, and Brain Sciences, Division of Psychology and Language Sciences, Institute of Behavioural Neuroscience, University College London, London WC1H 0AP, United Kingdom
    J Neurosci 31:5253-61. 2011
    ....
  22. ncbi Theta-paced flickering between place-cell maps in the hippocampus
    Karel Jezek
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, Olav Kyrres gate 9, MTFS, 7489 Trondheim, Norway
    Nature 478:246-9. 2011
    ..Repetition of pattern-completion processes across successive theta cycles may facilitate error correction and enhance discriminative power in the presence of weak and ambiguous input cues...
  23. ncbi Knowing where and getting there: a human navigation network
    E A Maguire
    Wellcome Department of Cognitive Neurology, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Science 280:921-4. 1998
    ..These findings outline a network of brain areas that support navigation in humans and link the functions of these regions to physiological observations in other mammals...
  24. pmc Dual phase and rate coding in hippocampal place cells: theoretical significance and relationship to entorhinal grid cells
    John O'Keefe
    Department of Anatomy and Developmental Biology, University College London
    Hippocampus 15:853-66. 2005
    ..Finally, we propose a model of the firing of the recently discovered "grid cells" in entorhinal cortex as part of a path-integration system, in combination with place cells and head-direction cells...
  25. ncbi Place cells, grid cells, and the brain's spatial representation system
    Edvard I Moser
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Annu Rev Neurosci 31:69-89. 2008
    ....
  26. ncbi Cortical dynamics of contextually cued attentive visual learning and search: spatial and object evidence accumulation
    Tsung Ren Huang
    Department of Cognitive and Neural Systems, Center for Adaptive Systems, Boston University, 677 Beacon Street, Boston, MA 02215, USA
    Psychol Rev 117:1080-112. 2010
    ..Model ventral prefrontal cortex (area 47/12) primes possible target identities in inferior temporal cortex based on the history of viewed objects represented in perirhinal cortex...
  27. pmc Frontoparietal cortex controls spatial attention through modulation of anticipatory alpha rhythms
    Paolo Capotosto
    Dipartimento di Scienze Cliniche e Bioimmagini and Istituto di Tecnologie Avanzate Biomediche Università G D Annunzio, 66013 Chieti, Italy
    J Neurosci 29:5863-72. 2009
    ..These results support the causal role of the dorsal frontoparietal network in the control of visuospatial attention, and suggest that this is partly exerted through the synchronization of occipital visual neurons...
  28. ncbi Hippocampal neurons encode information about different types of memory episodes occurring in the same location
    E R Wood
    Laboratory of Cognitive Neurobiology, Boston University, Massachusetts 02215, USA
    Neuron 27:623-33. 2000
    ..This pattern of results suggests that hippocampal representations encode some of the information necessary for representing specific memory episodes...
  29. ncbi Modeling place fields in terms of the cortical inputs to the hippocampus
    T Hartley
    Institute of Cognitive Neuroscience, University College London, UK
    Hippocampus 10:369-79. 2000
    ..The cells' behavior can be predicted for novel environments of arbitrary size and shape, or for manipulations such as introducing a barrier. The model can be extended to make behavioral predictions regarding spatial memory...
  30. ncbi Neuronal synchronization along the dorsal visual pathway reflects the focus of spatial attention
    Markus Siegel
    Department of Neurophysiology and Pathophysiology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Neuron 60:709-19. 2008
    ....
  31. pmc Acetylcholine dynamically controls spatial integration in marmoset primary visual cortex
    M J Roberts
    Psychology Brain and Behavior, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    J Neurophysiol 93:2062-72. 2005
    ..The natural release of ACh is strongly linked with states of arousal and attention. Our results may therefore be relevant to the neurobiological mechanism of attention...
  32. ncbi Attentional resolution and the locus of visual awareness
    S He
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 383:334-7. 1996
    ..We suggest that the attentional filter acts in one or more higher visual cortical areas to restrict the availability of visual information to conscious awareness...
  33. ncbi Long-lasting amelioration of visuospatial neglect by prism adaptation
    Francesca Frassinetti
    Dipartimento di Psicologia, Universita degli Studi di Bologna, Bologna, Italy
    Brain 125:608-23. 2002
    ..In conclusion, these findings show that prism adaptation is a productive way of achieving long-lasting improvements in neglect treatment...
  34. pmc Evidence for grid cells in a human memory network
    Christian F Doeller
    UCL Institute of Cognitive Neuroscience, London WC1N 3AR, UK
    Nature 463:657-61. 2010
    ..Our results provide evidence for grid-cell-like representations in humans, and implicate a specific type of neural representation in a network of regions which supports spatial cognition and also autobiographical memory...
  35. pmc Grid cells and theta as oscillatory interference: theory and predictions
    Neil Burgess
    Institute of Cognitive Neuroscience, University College London
    Hippocampus 18:1157-74. 2008
    ..Qualitative predictions are given for the properties of the VCOs, and the relationship between environmental novelty, the two components of theta, grid scale and place cell remapping...
  36. ncbi Direct evidence for a parietal-frontal pathway subserving spatial awareness in humans
    Michel Thiebaut de Schotten
    INSERM Unit 610, Assistance Publique Hopitaux de Paris, Hopital de la Salpetriere, 75013 Paris, France
    Science 309:2226-8. 2005
    ..These findings suggest that parietal-frontal communication is necessary for the symmetrical processing of the visual scene...
  37. ncbi Neural mechanisms of visual attention: how top-down feedback highlights relevant locations
    Yuri B Saalmann
    Department of Optometry and Vision Sciences, University of Melbourne, Parkville 3010, Australia
    Science 316:1612-5. 2007
    ..Parietal neurons may thus selectively increase activity in earlier sensory areas to enable focused spatial attention...
  38. ncbi Neural simulation of action: a unifying mechanism for motor cognition
    M Jeannerod
    Institut des Sciences Cognitives, 67 Boulevard Pinel, Bron, 69675, France
    Neuroimage 14:S103-9. 2001
    ..The function of this process of simulation would be not only to shape the motor system in anticipation to execution, but also to provide the self with information on the feasibility and the meaning of potential actions...
  39. ncbi Spatial cognition and the brain
    Neil Burgess
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
    Ann N Y Acad Sci 1124:77-97. 2008
    ....
  40. ncbi From thought to action: the parietal cortex as a bridge between perception, action, and cognition
    Jacqueline Gottlieb
    Center for Neurobiology and Behavior and Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Neuron 53:9-16. 2007
    ..By specifying attentional priority as a synthesis of multiple task demands, LIP operates at the interface of perception, action, and cognition...
  41. ncbi What determines our navigational abilities?
    Thomas Wolbers
    Centre for Cognitive and Neural Systems, University of Edinburgh, Edinburgh, EH8 9JZ, UK
    Trends Cogn Sci 14:138-46. 2010
    ..Together, the findings converge into an emerging model of how different factors interact to produce individual patterns of navigational performance...
  42. ncbi Human parietal cortex in action
    Jody C Culham
    Department of Psychology, Social Science Centre, University of Western Ontario, London, Ontario, Canada, N6A 5C2
    Curr Opin Neurobiol 16:205-12. 2006
    ..We review the known subregions of the human posterior parietal cortex and the principles behind their organization...
  43. ncbi Distinct ensemble codes in hippocampal areas CA3 and CA1
    Stefan Leutgeb
    Centre for the Biology of Memory, Medical Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 305:1295-8. 2004
    ..In CA1, the activated populations overlapped, and the overlap increased in similar enclosures. After exposure to a novel room, ensemble activity developed slower in CA3 than CA1, suggesting that the representations emerged independently...
  44. ncbi FMRI evidence for a 'parietal reach region' in the human brain
    Jason D Connolly
    CIHR Group on Action and Perception, Department of Psychology, University of Western Ontario, London, Ontario, N6A 5C2, Canada
    Exp Brain Res 153:140-5. 2003
    ..We therefore conclude that activation in this region is related to specific motor intent; i.e. it encodes information related to the subject's intention to make a specific movement to a particular spatial location...
  45. pmc Topographic maps in human frontal and parietal cortex
    Michael A Silver
    School of Optometry, Helen Wills Neuroscience Institute, and Henry H Wheeler, Jr Brain Imaging Center, University of California, Berkeley, Berkeley, CA 94720, USA
    Trends Cogn Sci 13:488-95. 2009
    ..The study of higher-order topographic cortex promises to yield unprecedented insights into the neural mechanisms of cognitive processes and, in conjunction with parallel studies in non-human primates, into the evolution of cognition...
  46. ncbi Time in the mind: using space to think about time
    Daniel Casasanto
    Department of Psychology, Jordan Hall, Bldg 420, Stanford University, Stanford, CA 94305, USA
    Cognition 106:579-93. 2008
    ..Results suggest that our mental representations of things we can never see or touch may be built, in part, out of representations of physical experiences in perception and motor action...
  47. ncbi Extending the spontaneous preference test of recognition: evidence of object-location and object-context recognition
    S L Dix
    School of Psychology, University of Cardiff Wales, Cardiff, UK
    Behav Brain Res 99:191-200. 1999
    ..In the standard condition and the context condition, the first 2 min were found to be the most sensitive period. In the two conditions involving a position change, discrimination was only evident in the first minute...
  48. pmc Oscillatory alpha-band mechanisms and the deployment of spatial attention to anticipated auditory and visual target locations: supramodal or sensory-specific control mechanisms?
    Snigdha Banerjee
    The Cognitive Neurophysiology Laboratory, Children s Evaluation and Rehabilitation Center, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 31:9923-32. 2011
    ..The data support an "interactivity account," whereby a supramodal system interacts with sensory-specific control systems during deployment of spatial attention...
  49. ncbi Multiple reference frames used by the human brain for spatial perception and memory
    Gaspare Galati
    Department of Psychology, Sapienza University, Rome, Italy
    Exp Brain Res 206:109-20. 2010
    ..This effect can be dissociated from the consequences of an explicit memory recall of landmark locations, a process that further engages the retrosplenial cortex...
  50. pmc Distinct error-correcting and incidental learning of location relative to landmarks and boundaries
    Christian F Doeller
    Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom
    Proc Natl Acad Sci U S A 105:5909-14. 2008
    ..Finally, the demonstration that reinforcement learning applies selectively to formally equivalent aspects of task-performance supports broader consideration of two-system models in analyses of learning and decision making...
  51. ncbi Humans use internal models to construct and update a sense of verticality
    Julien Barra
    Laboratoire de Psychologie et Neuropsychologie Cognitive, Universite Paris Descartes, FRE 3292, France
    Brain 133:3552-63. 2010
    ..We conclude that humans construct and update internal models of verticality in which somatosensory information plays an important role...
  52. pmc If I were you: perceptual illusion of body swapping
    Valeria I Petkova
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 3:e3832. 2008
    ..Our results are of fundamental importance because they identify the perceptual processes that produce the feeling of ownership of one's body...
  53. ncbi Place cells and place recognition maintained by direct entorhinal-hippocampal circuitry
    Vegard H Brun
    Neuroscience Unit, Medical Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 296:2243-6. 2002
    ..These results suggest that the hippocampus contains two functionally separable memory circuits: The direct entorhinal-CA1 system is sufficient for recollection-based recognition memory, but recall depends on intact CA3-CA1 connectivity...
  54. pmc Cosine directional tuning of theta cell burst frequencies: evidence for spatial coding by oscillatory interference
    Adam C Welday
    Psychology Department, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 31:16157-76. 2011
    ..These results suggest that theta cells may serve a high-level computational function by encoding a basis set of oscillatory signals that interfere with one another to synthesize spatial memory representations...
  55. ncbi Grid cell hexagonal patterns formed by fast self-organized learning within entorhinal cortex
    Himanshu Mhatre
    Department of Cognitive and Neural Systems, Center for Adaptive Systems, Boston University, Boston, Massachusetts, USA
    Hippocampus 22:320-34. 2012
    ..These results support an emerging unified computational framework based on a hierarchy of self-organizing maps for explaining how entorhinal-hippocampal interactions support spatial navigation...
  56. ncbi A double dissociation between hippocampal subfields: differential time course of CA3 and CA1 place cells for processing changed environments
    Inah Lee
    Department of Neurobiology and Anatomy, W M Keck Center for the Neurobiology of Learning and Memory, University of Texas Medical School at Houston, Houston, Texas 77225, USA
    Neuron 42:803-15. 2004
    ....
  57. ncbi Selectivity and spatial distribution of signals from the receptive field surround in macaque V1 neurons
    James R Cavanaugh
    Center for Neural Science, New York University, New York City, New York 10003, USA
    J Neurophysiol 88:2547-56. 2002
    ..We suggest that the underlying mechanism of this complexity may involve interactions between relatively simple center and surround mechanisms...
  58. ncbi Human hippocampus and viewpoint dependence in spatial memory
    John A King
    Institute of Cognitive Neuroscience and Department of Anatomy, University College, London, United Kingdom
    Hippocampus 12:811-20. 2002
    ..In addition, they suggest an extremely sensitive test for human hippocampal damage, and hint at the nature of the hippocampal role in episodic recollection...
  59. ncbi "I have often walked down this street before": fMRI studies on the hippocampus and other structures during mental navigation of an old environment
    R Shayna Rosenbaum
    Department of Psychology, University of Toronto, Toronto, Ontario, Canada
    Hippocampus 14:826-35. 2004
    ..Importantly, right medial temporal lobe activity was observed, its magnitude equivalent across all tasks, though the core of the activated region was in the parahippocampal gyrus, barely touching the hippocampus proper...
  60. ncbi Is there a geometric module for spatial orientation? Insights from a rodent navigation model
    Denis Sheynikhovich
    Laboratory of Computational Neuroscience, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Psychol Rev 116:540-66. 2009
    ..Moreover, the same model also describes behavioral results in different types of water-maze tasks...
  61. ncbi Fragmentation of grid cell maps in a multicompartment environment
    Dori Derdikman
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, MTFS, Norwegian University of Science and Technology, Trondheim, Norway
    Nat Neurosci 12:1325-32. 2009
    ..These results indicate that spatial environments are represented in entorhinal cortex and hippocampus as a mosaic of discrete submaps that correspond to the geometric structure of the space...
  62. pmc Independent rate and temporal coding in hippocampal pyramidal cells
    John Huxter
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 425:828-32. 2003
    ....
  63. pmc Functional imaging of hippocampal place cells at cellular resolution during virtual navigation
    Daniel A Dombeck
    Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA
    Nat Neurosci 13:1433-40. 2010
    ..The combination of virtual reality and high-resolution functional imaging should allow a new generation of studies to investigate neuronal circuit dynamics during behavior...
  64. pmc Dorsal premotor neurons encode the relative position of the hand, eye, and goal during reach planning
    Bijan Pesaran
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Neuron 51:125-34. 2006
    ..Such a relative position code may play an important role in coordinating hand and eye movements by computing their relative position...
  65. ncbi Gray matter differences correlate with spontaneous strategies in a human virtual navigation task
    Veronique D Bohbot
    Department of Psychiatry, McGill University, Verdun, Quebec, Canada H4H 1R3
    J Neurosci 27:10078-83. 2007
    ..In addition, these data suggest that spatial strategies may provide protective effects against degeneration of the hippocampus that occurs with normal aging...
  66. ncbi Parietal cortex mediates voluntary control of spatial and nonspatial auditory attention
    Sarah Shomstein
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 26:435-9. 2006
    ....
  67. pmc A new role for the parahippocampal cortex in representing space
    Sinéad L Mullally
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 31:7441-9. 2011
    ....
  68. pmc Accurate path integration in continuous attractor network models of grid cells
    Yoram Burak
    Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 5:e1000291. 2009
    ..We suggest experiments to test the continuous attractor model and differentiate it from models in which single cells establish their responses independently of each other...
  69. pmc Awake replay of remote experiences in the hippocampus
    Mattias P Karlsson
    W M Keck Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, USA
    Nat Neurosci 12:913-8. 2009
    ..Our results indicate that the hippocampus consistently replays past experiences during brief pauses in waking behavior, suggesting a role for waking replay in memory consolidation and retrieval...
  70. ncbi Progressive increase in grid scale from dorsal to ventral medial entorhinal cortex
    Vegard Heimly Brun
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, Trondheim, Norway
    Hippocampus 18:1200-12. 2008
    ....
  71. ncbi Neuroanatomy of hemispatial neglect and its functional components: a study using voxel-based lesion-symptom mapping
    Vincent Verdon
    Department of Psychology, University of Geneva, Geneva, Switzerland
    Brain 133:880-94. 2010
    ....
  72. ncbi Neural basis and recovery of spatial attention deficits in spatial neglect
    Maurizio Corbetta
    Department of Neurology, Washington University, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Neurosci 8:1603-10. 2005
    ....
  73. ncbi Visuo-spatial neglect: a systematic review of current interventions and their effectiveness
    Jacques Luaute
    Hospices Civils de Lyon, Hopital Henry Gabrielle, Rééducation Neurologique, Mouvement et Handicap, Saint Genis Laval, F 69230, France
    Neurosci Biobehav Rev 30:961-82. 2006
    ..Sensory stimulations alone and Fresnel prisms do not appear to be functionally relevant. For the other methods, the actual literature is not sufficient to conclude whether or not a long-term functional improvement can be achieved...
  74. ncbi Development of cue integration in human navigation
    Marko Nardini
    Centre for Brain and Cognitive Development, Birkbeck College, University of London, London, UK
    Curr Biol 18:689-93. 2008
    ..Humans can integrate spatial cues nearly optimally to navigate, but this ability depends on an extended developmental process...
  75. ncbi Cognitive strategies dependent on the hippocampus and caudate nucleus in human navigation: variability and change with practice
    Giuseppe Iaria
    Douglas Hospital Research Center, McGill University, Verdun, Quebec, Canada, H4H 1R3
    J Neurosci 23:5945-52. 2003
    ..Activation common to both groups was observed in the posterior parietal and frontal cortex. These results provide the first evidence for spontaneous variability and shift in neural mechanisms during navigation in humans...
  76. ncbi Quantitative characterization of visual response properties in the mouse dorsal lateral geniculate nucleus
    Matthew S Grubb
    University Laboratory of Physiology, Oxford OX1 3PT, United Kingdom
    J Neurophysiol 90:3594-607. 2003
    ..We looked for evidence of parallel processing in the mouse dLGN and found it only in a functional difference between ON- and OFF-center cells: ON-center cells were more sensitive to stimulus contrast than their OFF-center neighbors...
  77. ncbi Medial parietal cortex encodes perceived heading direction in humans
    Oliver Baumann
    Queensland Brain Institute and School of Psychology, University of Queensland, St Lucia, Queensland 4072, Australia
    J Neurosci 30:12897-901. 2010
    ....
  78. ncbi Two forms of spatial imagery: neuroimaging evidence
    William L Thompson
    Harvard University, Boston, Massachusetts, UK
    Psychol Sci 20:1245-53. 2009
    ..These differences in activation provide evidence that there are at least two different types of spatial imagery...
  79. ncbi Integration of diverse information in working memory within the frontal lobe
    V Prabhakaran
    Program in Neurosciences, Jordan Hall, Bldg 420, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 3:85-90. 2000
    ..The role of prefrontal cortex in integrating multiple forms of information in working memory may underlie its unique contribution to high-level cognition that demands flexible mental representations...
  80. ncbi An area specialized for spatial working memory in human frontal cortex
    S M Courtney
    Laboratory of Brain and Cognition, National Institute of Mental Health, Building 10, Room 4C104, 10 Center Drive, Bethesda, MD 20892 1366, USA
    Science 279:1347-51. 1998
    ..This area is located more superiorly and posteriorly in the human than in the monkey brain, which may explain why it was not recognized previously...
  81. ncbi Functional specificity of superior parietal mediation of spatial shifting
    R Vandenberghe
    Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Medical School, Chicago, Illinois, USA
    Neuroimage 14:661-73. 2001
    ..The response to spatial shifts and the correlation with the distance between the original and the new location points to a specific role of the superior parietal gyrus in shifting the locus of spatial attention...
  82. ncbi Spatiotemporal elements of macaque v1 receptive fields
    Nicole C Rust
    Center for Neural Science and New York University, New York, New York 10003, USA
    Neuron 46:945-56. 2005
    ..Suppressive signals are especially potent in direction-selective cells, where they reduce responses to stimuli moving in the nonpreferred direction...
  83. pmc Parallel striatal and hippocampal systems for landmarks and boundaries in spatial memory
    Christian F Doeller
    Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom
    Proc Natl Acad Sci U S A 105:5915-20. 2008
    ....
  84. ncbi Hippocampal long-term depression: master or minion in declarative memory processes?
    Anne Kemp
    Learning and Memory Research, Medical Faculty, Ruhr University Bochum, Universitatsstrasse 150, MABF 01 551, 44780 Bochum, Germany
    Trends Neurosci 30:111-8. 2007
    ..Accumulating evidence supports the idea that LTP and LTD enable distinct and separate forms of information storage, which together facilitate the generation of a spatial cognitive map...
  85. ncbi Spatial memory: how egocentric and allocentric combine
    Neil Burgess
    Institute of Cognitive Neuroscience and Department of Anatomy, University College London, 17 Queen Square, London WC1N 3AR, UK
    Trends Cogn Sci 10:551-7. 2006
    ..Identifying the neuronal mechanisms and functional roles of each type of representation, and of their interactions, promises to provide a framework for investigation of the organization of human memory more generally...
  86. pmc Place-selective firing contributes to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in open-field exploration
    Jozsef Csicsvari
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    Eur J Neurosci 26:704-16. 2007
    ..We therefore propose that both place-related drive and the firing history of cells contribute to reverse reactivation during eSWRs...
  87. ncbi Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning
    Marta A P Moita
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 37:485-97. 2003
    ..These findings may help to elucidate how the hippocampus contributes to context-specific memory formation during associative learning...
  88. ncbi The information content of panoramic images II: view-based navigation in nonrectangular experimental arenas
    Allen Cheung
    ARC Centre of Excellence in Vision Science, Research School of Biological Sciences, The Australian National University, Canberra, Australia
    J Exp Psychol Anim Behav Process 34:15-30. 2008
    ..For both experiments, this model mimics many aspects of rat behavior. View-based navigation provides a sufficient and parsimonious explanation for a range of navigational behaviors of rats under these experimental conditions...
  89. ncbi Space re-exploration in hemispatial neglect
    Andrew Parton
    Centre for Cognition and Neuroimaging, Brunel University, Uxbridge, London, UK
    Neuroreport 17:833-6. 2006
    ..Finally, manipulating the visual salience of found targets altered the degree of neglect, but not revisit rates. Space exploration appears to be modulated both by the ability to keep track of spatial locations and by stimulus salience...
  90. ncbi Protein phosphatase 1 is a molecular constraint on learning and memory
    David Genoux
    Institute of Cell Biology, Swiss Federal Institute of Technology, Department of Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Nature 418:970-5. 2002
    ..Our findings emphasize the physiological importance of PP1 as a suppressor of learning and memory, and as a potential mediator of cognitive decline during ageing...
  91. ncbi Visuo-motor coordination and internal models for object interception
    Myrka Zago
    Laboratory of Human Neurophysiology, IRCCS Santa Lucia Foundation, University of Rome Tor Vergata, Via Ardeatina 306, 00179, Rome, Italy
    Exp Brain Res 192:571-604. 2009
    ....
  92. ncbi Contrast's effect on spatial summation by macaque V1 neurons
    M P Sceniak
    Center for Neural Science, New York University, 4 Washington Pl, New York, New York 10003, USA
    Nat Neurosci 2:733-9. 1999
    ..3-fold greater at low contrast. This adaptive increase in spatial summation at low contrast was seen in cells throughout V1 and was independent of surround inhibition...
  93. ncbi Hearing visual motion in depth
    Norimichi Kitagawa
    Department of Psychology, Tokyo Metropolitan University, 1 1, Minami Osawa, Hachioji shi, Tokyo 192 0397, Japan
    Nature 416:172-4. 2002
    ..The results provide psychophysical evidence that, for processing of motion in depth, the auditory system responds to both auditory changing intensity and visual motion in depth...
  94. ncbi Moving the eyes along the mental number line: comparing SNARC effects with saccadic and manual responses
    Wolf Schwarz
    University of Nijmegen, Nijmegen, The Netherlands
    Percept Psychophys 66:651-64. 2004
    ....
  95. pmc Neurophysiological correlates of relatively enhanced local visual search in autistic adolescents
    Zina M Manjaly
    Institute of Neuroscience and Biophysics, Department of Medicine, Research Centre Julich, 52425 Julich, Germany
    Neuroimage 35:283-91. 2007
    ..These results suggest that enhanced local processing in early visual areas, as opposed to impaired processing of global context, is characteristic for performance of the EFT by autistic patients...
  96. ncbi Pattern span: a tool for unwelding visuo-spatial memory
    S Della Sala
    Department of Psychology, University of Aberdeen, Old Aberdeen, UK
    Neuropsychologia 37:1189-99. 1999
    ..The VPT will be a useful neuropsychological instrument for measuring the visual component...
  97. ncbi A cortical representation of the local visual environment
    R Epstein
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 392:598-601. 1998
    ..This response is reduced if the surfaces in the scene are rearranged so that they no longer define a coherent space. We propose that the PPA represents places by encoding the geometry of the local environment...
  98. ncbi Direct visuomotor transformations for reaching
    Christopher A Buneo
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Nature 416:632-6. 2002
    ..Data obtained in the adjacent parietal reach region (PRR) indicate that this transformation may be achieved by vectorially subtracting hand location from target location, with both locations represented in eye-centred coordinates...
  99. pmc Topographic maps of visual spatial attention in human parietal cortex
    Michael A Silver
    Department of Psychology, Stanford University, Stanford, CA, USA
    J Neurophysiol 94:1358-71. 2005
    ..The two proposed cortical areas exhibited relatively little response to passive visual stimulation in comparison with early visual areas. These results provide evidence for multiple topographic maps in human parietal cortex...
  100. ncbi Dissociable retrosplenial and hippocampal contributions to successful formation of survey representations
    Thomas Wolbers
    NeuroImage Nord, Department of Neurology, Universitatsklinikum Hamburg Eppendorf, 20246 Hamburg, Germany
    J Neurosci 25:3333-40. 2005
    ....
  101. pmc Control of eye movements and spatial attention
    T Moore
    Department of Psychology, Princeton University, Princeton, NJ 08544 1010, USA
    Proc Natl Acad Sci U S A 98:1273-6. 2001
    ..We found that we could improve the monkey's performance with microstimulation when, but only when, the object to be attended was positioned in the space represented by the cortical stimulation site...

Research Grants66

  1. MULTIMODAL BASIS FOR EGOCENTRIC PERCEPTION OF SPACE
    Leonard Matin; Fiscal Year: 2004
    ..from Applicant's abstract): Many neurological deficits and disease entities involve difficulties in visual space perception and visually guided behavior, and may involve fine manual control and/or gross motor behavior...
  2. Egocentric reference frames in memory
    David Waller; Fiscal Year: 2005
    ..Findings may also lead to ways of improving spatial abilities in the general population. ..
  3. Cue Reliability and Depth Calibration During Space Perception
    Benjamin T Backus; Fiscal Year: 2011
    ....
  4. Psychophysical Research on Auditory/Visual Space Perception and Navigation
    PAVEL A ZAHORIK; Fiscal Year: 2013
    ..Moreover, it will provide a vehicle for future studies to advance the field of multisensory space perception. The proposed research is relevant to public health because it will lead to a better understanding of how ..
  5. Mechanisms of Intermediate Distance Space Perception
    ZIJIANG HE; Fiscal Year: 2011
    Visual space perception in the intermediate distance range (2-25 meters) serves a multi-faceted function. It allows the observer to perceive the 3D shapes, sizes and locations of objects, orient in space and guides our actions...
  6. Mechanisms of Intermediate Distance Space Perception
    ZIJIANG HE; Fiscal Year: 2007
    Visual space perception in the intermediate distance range (2-25 meters) serves a multi-faceted function. It allows the observer to perceive the 3D shapes, sizes and locations of objects, orient in space and guide our actions...
  7. CORTICAL MECHANISMS OF VISUAL SPACE PERCEPTION
    ALLAN DOBBINS; Fiscal Year: 2003
    ..abstract_text> ..
  8. Molecular Mechanisms in TCR Reactivity to Self Ligands
    STEPHEN JAMESON; Fiscal Year: 2005
    ..This has health implications for recovery of the T-cell pool in patients suffering from T lymphopenia due to disease (e.g. AIDS), or therapeutic treatments (such as bone morrow transplant). ..
  9. NAVIGATING WITHOUT VISION--BASIC AND APPLIED RESEARCH
    JACK LOOMIS; Fiscal Year: 2002
    ..There are 4 basic research topics: auditory space perception, path integration, the learning of spatial layout, and the learning of route configurations by "preview"...
  10. MOTION INFORMATION AND INFANTS' COORDINATED BEHAVIOR
    Daniel Ashmead; Fiscal Year: 1992
    The general topic of this research is how human infants coordinate their space perception with their actions...
  11. FMRI OF HUMAN AUDITORY SPATIAL PROCESSING
    James Lewis; Fiscal Year: 2002
    ..In addition to its relevance for understanding the neural basis of auditory space perception, the results of this study may also be of significant use in understanding and diagnosing deficits in ..
  12. MODELS OF APPARENT SIZE AND DISTANCE
    Martha Teghtsoonian; Fiscal Year: 1980
    ..The development of space perception will be studied by designing bias-free scaling procedures to measure apparent size and distance for children ..
  13. Contextual cueing and implicit learning
    Yuhong Jiang; Fiscal Year: 2009
    ..Understanding its cognitive and neural mechanisms is the first step toward understanding this ability in normal adults as well as in those whose explicit learning and memory mechanisms are impaired. ..
  14. Response Selection as a Function of Age
    Robert Proctor; Fiscal Year: 2002
    ..These guidelines will lead to development of products and environments that allow elderly adults to remain more independent and to engage safely in more activities in their daily lives. ..
  15. The Development of Visual Integration & Attention: A High-Density EEG Study
    Melanie Palomares; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  16. A Spiking Model of Hippocampus for Guiding Behavior
    Michael Hasselmo; Fiscal Year: 2006
    ..U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA. [unreadable] [unreadable]..
  17. A Dynamic Process Approach to Cognitive Representation
    John Lipinski; Fiscal Year: 2006
    ..This empirical work will lay the essential groundwork for development of a formal model linking linguistic and non-linguistic representations of space. ..
  18. Motor Learning for the Control of an Assistive Device
    Ferdinando Mussa Ivaldi; Fiscal Year: 2008
    ..The results of these studies are expected to guide the development of new technology for assistive devices based on human motor learning and on engineering of adaptive control. Project Description Page 6 ..
  19. NEURAL BASIS OF SPATIAL COGNITION
    JEFFREY TAUBE; Fiscal Year: 2003
    ..Learning how spatial information is processed in the rat brain will give us clues about the complex nature of spatial processes in humans. ..
  20. Functional Remapping of Hand Control
    FERDINANDO ALESSANDRO MUSSA IVALDI; Fiscal Year: 2010
    ..expected that this study will identify new means for exploiting the ability of the nervous system to reorganize itself so as to facilitate training novel hand movements and to recover skills lost to stroke and other neuromotor disorders ..
  21. Long-term Ambulatory Gait Monitor for Parkinson's Disease
    Steven Moore; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. NEURAL MECHANISMS OF DIRECTIONAL ORIENTATION
    JEFFREY TAUBE; Fiscal Year: 2004
    ....
  23. VESTIBULAR INFLUENCES ON SPATIAL ORIENTATION
    Richard Lewis; Fiscal Year: 2008
    ..abstract_text> ..
  24. Neural Mechanisms of Planning and Control of Movement
    Giuseppe Pellizzer; Fiscal Year: 2005
    ....
  25. Interaction torques in voluntary turning and reaching
    James R Lackner; Fiscal Year: 2010
    ..The experimental findings and analyses will provide a comprehensive evaluation of the role of feedforward predictive mechanisms in the control of reaching movements involving body rotation. ..
  26. Neural Correlates of Methamphetamine Use in Schizophrenia: An MRS Study
    Ruth Salo; Fiscal Year: 2007
    ..These findings will have important implications for neurobiological models of comorbid substance abuse and treatment. [unreadable] [unreadable] [unreadable]..
  27. Age related effects on macaque auditory cortex
    Gregg Recanzone; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  28. Identify abnormal neurocognitive circuits in temporal lobe epilepsy
    Joseph Tracy; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. The VETSA Longitudinal Twin Study of Cortisol and Aging
    William Kremen; Fiscal Year: 2007
    ..Using multivariate twin analytic approaches, we will determine the extent of genetic, and shared and unique environmental factors influencing cortisol in midlife as well as their association with other key measures. ..
  30. Cognitive and Neural Consequence of Long Term Cortisol Exposure in Human Aging.
    Scott D Moffat; Fiscal Year: 2010
    ....
  31. Adolescent Neurodevelopment and Alcohol
    Robert Thoma; Fiscal Year: 2008
    ..abstract_text> ..
  32. The development of visual short-term memory in infancy
    LISA OAKES; Fiscal Year: 2009
    ..abstract_text> ..
  33. MULTI-MODAL INTERACTIONS IN SPATIAL AND TEMPORAL PERCEPTION
    Gregg Recanzone; Fiscal Year: 2009
    ..These insights will provide a cornerstone for understanding complex perceptions and cognitive ability. ..
  34. Learning dependent neural encoding in the hippocampus
    Matthew L Shapiro; Fiscal Year: 2010
    ..The research should inform the design of rational treatments for amnesia (e.g. by stroke or Alzheimer's disease), including the future development of neural prostheses. ..
  35. Adapting Experimental Cognitive and Affective Tasks for Schizophrenia
    Ruben C Gur; Fiscal Year: 2010
    ..We will evaluate a dataset from an existing battery to fine tune available measures and adapt new tasks to augment the battery. ..
  36. Synaptic Dialogue: Plasticity Leading to Memory Storage
    Aryeh Routtenberg; Fiscal Year: 2010
    ..abstract_text> ..
  37. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
    ..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
  38. Raloxifene in Women with AD: Randomized Controlled Trial
    VICTOR HENDERSON; Fiscal Year: 2007
    ..It is anticipated that findings from this pilot study will provide useful guidance to plan and conduct future studies of raloxifene in women with mild to moderate symptoms of dementia due to AD. ..
  39. Parietal mechanisms of vision and attention
    Jacqueline Gottlieb; Fiscal Year: 2007
    ..The results are expected to significantly advance our understanding of the neural mechanisms of attention and to bring us closer toward establishing an animal model of neglect. ..
  40. The cognitive neuroscience of body knowledge
    H Coslett; Fiscal Year: 2007
    ..Understanding the cerebral basis of motor control and the body schema is likely to contribute substantially to the development of interventions that target these representations. [unreadable] [unreadable]..
  41. Hemodynamic predictors of brain and cognitive aging
    Naftali Raz; Fiscal Year: 2005
    ....
  42. WEARABLE ARTIFICIAL LABYRINTH IN MOTION SICKNESS/VERTIGO
    WESLEY KRUEGER; Fiscal Year: 2005
    ....
  43. Adaptation to controlled vestibular stimulation
    DANIEL MERFELD; Fiscal Year: 2005
    ..All of these proposed specific aims will be investigated by measuring changes in the vestibulo-ocular responses induced by changes in chronic, patterned, electrical stimulation of the peripheral vestibular system. ..
  44. Cognitive Sequelae of Methamphetamine Abuse
    Ruth Salo; Fiscal Year: 2005
    ..abstract_text> ..
  45. FUNCTIONAL ORGANIZATION--NONPRIMARY AUDITORY CORTEX
    JOSEF RAUSCHECKER; Fiscal Year: 2004
    ....
  46. Modulation of visual cortex by attention and uncertainty
    Michael Silver; Fiscal Year: 2004
    ..abstract_text> ..
  47. REGULATORY MECHANISMS UNDERLYING POSTURAL STABILITY
    EMILY KESHNER; Fiscal Year: 2004
    ..Quantification of the adaptation process should reveal its effectiveness in a natural, dynamic environment and may suggest methods for remediation of postural instability. ..
  48. Infant spatial categorization
    Marianella Casasola; Fiscal Year: 2004
    ..Finally, the findings will document whether the development of infant spatial categorization varies in infants and toddlers raised in different cultures and with languages other than English. ..
  49. Behavioral Model of Contextual Attention in the Monkey
    J Jentsch; Fiscal Year: 2003
    ..The development of such an approach to modeling contextual aspects of attention, in particular, in animals should be a major advance linking pre-clinical psychopharmacological studies and treatment-based research for schizophrenia. ..
  50. NEURAL CORRELATES OF AGE RELATED DIFFERENCES IN MEMORY
    Naftali Raz; Fiscal Year: 2003
    ....
  51. Figure-ground segregation and self-sitting in infancy
    LISA OAKES; Fiscal Year: 2006
    ..abstract_text> ..
  52. CHRONIC COCAINE ABUSE EFFECTS ON P50 AND P3A ERPS
    George Fein; Fiscal Year: 2001
    ..Finally, samples of active cocaine abusers will be studied. ..
  53. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  54. CRCNS: Innovative technologies inspired by biosonar
    Cynthia Moss; Fiscal Year: 2007
    ..It will also lay the foundation for a wide range of biomedical applications, such as implantable neural prostheses, ultra-lightweight low power sensors, controllers, medical tool design, and sonar-based assistive medical devices. ..
  55. ANALYSIS OF SPACE BY THE AUDITORY SYSTEM
    ERIC KNUDSEN; Fiscal Year: 2007
    ..abstract_text> ..
  56. Attention and Oculomotor Control: Attentional Resolution
    Cathleen Moore; Fiscal Year: 2007
    ..We hypothesize, for example, that transient adaptation of the saccadic system will transfer to the attentional control system and alter observers' attentional resolution. ..
  57. Minimizing Instability with Dynamic Visual Inputs
    EMILY KESHNER; Fiscal Year: 2007
    ..Results from these studies will provide insight into the dynamics of the visual- vestibular interaction and identify specific quantitative protocols for therapeutic interventions with balance disorders. ..
  58. Task Practice Schedules to Enhance Recovery after Stroke
    Nicolas Schweighofer; Fiscal Year: 2006
    ..The hypothesis is that subjects with mild deficits benefit most from expanded variable practice, whereas subjects with moderate deficits benefit most from massed practice schedules. [unreadable] [unreadable]..
  59. PSYCHOLOGICAL STUDIES OF BINAURAL HEARING AND ATTENTION
    Ervin Hafter; Fiscal Year: 2006
    ..abstract_text> ..
  60. Peripheral Visual Function of Children with Low Vision
    JOSEPH LAPPIN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  61. An EEG Study of Neural Dynamics in Schizophrenia
    Kevin Spencer; Fiscal Year: 2006
    ..This project seeks to further this goal by studying how brainwave synchronization is related to perception and thinking in people who are healthy, and in people who have schizophrenia. [unreadable] [unreadable] [unreadable]..
  62. Function of a Neuropeptide Gene Family in C. elegans
    Christine Li; Fiscal Year: 2006
    ..In addition, because C. elegans is the current genetic model system for parasitic nematodes, elucidating the functions of neuropeptides and their signaling pathways may identify new antihelmintic drug targets. ..
  63. EFFECTS OF TEMPORAL STRUCTURE ON MEMORY FOR EVENTS
    Patricia Bauer; Fiscal Year: 2006
    ..Investigations of the long-term fate of early memories, and of the impact of early determinants on later auto-biographical reports, are the subjects of the final three experiments. ..
  64. Auditory response properties of the prefrontal cortex
    YALE COHEN; Fiscal Year: 2009
    ..abstract_text> ..