differential threshold

Summary

Summary: The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold.

Top Publications

  1. ncbi From physical time to the first and second moments of psychological time
    S Grondin
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Psychol Bull 127:22-44. 2001
  2. ncbi Adaptive psychophysical procedures
    B Treutwein
    Institut fur Medizinische Psychologie, Ludwig Maximilians Universitat Munchen, Germany
    Vision Res 35:2503-22. 1995
  3. ncbi Subtractive and divisive inhibition: effect of voltage-dependent inhibitory conductances and noise
    B Doiron
    Physics Department, University of Ottawa, Canada
    Neural Comput 13:227-48. 2001
  4. ncbi Discriminating time intervals presented in sequences marked by visual signals
    S Grondin
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Percept Psychophys 63:1214-28. 2001
  5. ncbi Duration discrimination in crossmodal sequences
    Simon Grondin
    Ecole de Psychologie, Universite Laval, Quebec, QC G1A 0V6, Canada
    Perception 38:1542-59. 2009
  6. ncbi Membrane and firing properties of avian medial vestibular nucleus neurons in vitro
    S Du Lac
    Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143 0444, USA
    J Comp Physiol A 176:641-51. 1995
  7. ncbi Topiramate and cortical excitability in humans: a study with repetitive transcranial magnetic stimulation
    M Inghilleri
    Dipartimento Scienze Neurologiche, Universita di Roma La Sapienza, Rome, Italy
    Exp Brain Res 174:667-72. 2006
  8. pmc Post-spike distance-to-threshold trajectories of neurones in monkey motor cortex
    Daniel Z Wetmore
    Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Physiol 555:831-50. 2004
  9. ncbi Biochemical signaling networks decode temporal patterns of synaptic input
    Upinder S Bhalla
    National Centre for Biological Sciences, GKVK Campus, Bangalore 560065, India
    J Comput Neurosci 13:49-62. 2002
  10. ncbi Effect of volitional inhibition on cortical inhibitory mechanisms
    Young H Sohn
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurophysiol 88:333-8. 2002

Research Grants

Detail Information

Publications226 found, 100 shown here

  1. ncbi From physical time to the first and second moments of psychological time
    S Grondin
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Psychol Bull 127:22-44. 2001
    ..Weber's law is a useful guide for studying psychological time, but it is also reasonable to assume that more than one so-called central timekeeper could contribute to perceiving time...
  2. ncbi Adaptive psychophysical procedures
    B Treutwein
    Institut fur Medizinische Psychologie, Ludwig Maximilians Universitat Munchen, Germany
    Vision Res 35:2503-22. 1995
    ..This review tries to illuminate the historical background of adaptive procedures, explain their differences and similarities, and provide criteria for choosing among the various techniques...
  3. ncbi Subtractive and divisive inhibition: effect of voltage-dependent inhibitory conductances and noise
    B Doiron
    Physics Department, University of Ottawa, Canada
    Neural Comput 13:227-48. 2001
    ..A simple leaky integrate-and-fire type model that incorporates the voltage dependence supports the results from our full ionic simulations...
  4. ncbi Discriminating time intervals presented in sequences marked by visual signals
    S Grondin
    Ecole de Psychologie, Universite Laval, Quebec, Canada
    Percept Psychophys 63:1214-28. 2001
    ..With both methods, the increase was well described by Weber's law--the Weber fraction was roughly constant--between 600 and 900 msec (Experiment 2), whereas between 900 and 1,200 msec (Experiment 3), the Weber fraction increased...
  5. ncbi Duration discrimination in crossmodal sequences
    Simon Grondin
    Ecole de Psychologie, Universite Laval, Quebec, QC G1A 0V6, Canada
    Perception 38:1542-59. 2009
    ..Finally, presenting a fixed interval in the first sequence resulted in better discrimination than presenting a variable interval in the first sequence. Implications for theories of timing are discussed...
  6. ncbi Membrane and firing properties of avian medial vestibular nucleus neurons in vitro
    S Du Lac
    Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143 0444, USA
    J Comp Physiol A 176:641-51. 1995
    ..These properties appear identical to those of rodent MVN neurons, suggesting that the composition and distribution of ion channels in the MVN neuronal membrane has been highly conserved across vertebrate species...
  7. ncbi Topiramate and cortical excitability in humans: a study with repetitive transcranial magnetic stimulation
    M Inghilleri
    Dipartimento Scienze Neurologiche, Universita di Roma La Sapienza, Rome, Italy
    Exp Brain Res 174:667-72. 2006
    ....
  8. pmc Post-spike distance-to-threshold trajectories of neurones in monkey motor cortex
    Daniel Z Wetmore
    Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Physiol 555:831-50. 2004
    ..This could act to enhance synchronized oscillatory discharge among populations of cells at functionally relevant frequencies...
  9. ncbi Biochemical signaling networks decode temporal patterns of synaptic input
    Upinder S Bhalla
    National Centre for Biological Sciences, GKVK Campus, Bangalore 560065, India
    J Comput Neurosci 13:49-62. 2002
    ..Thus the synaptic signaling network may function as a temporal decoder that transforms patterns from the time domain into the domain of chemical signaling. This may underlie different synaptic responses to different stimulus patterns...
  10. ncbi Effect of volitional inhibition on cortical inhibitory mechanisms
    Young H Sohn
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurophysiol 88:333-8. 2002
    ..The present results demonstrate that volitional inhibition enhances SICI but reduces LICI nonselectively. These results suggest that these two inhibitory mechanisms act differently during execution and suppression of voluntary movements...
  11. ncbi Flumazenil does not affect intracortical motor excitability in humans: a transcranial magnetic stimulation study
    H Y Jung
    Department of Rehabilitation Medicine, Inha University College of Medicine, Inchon, South Korea
    Clin Neurophysiol 115:325-9. 2004
    ..One inhibitory mechanism is supported by activity at benzodiazepine (BZP) receptors. In this study we investigate whether or not the BZP antagonist, flumazenil, increases cortical motor excitability in humans...
  12. ncbi The effects of prolonged intracortical microstimulation on the excitability of pyramidal tract neurons in the cat
    Douglas B McCreery
    Huntington Medical Research Institutes, Neural Engineering Laboratory, Pasadena, CA 91105, USA
    Ann Biomed Eng 30:107-19. 2002
    ....
  13. ncbi Finite element bidomain model of epiretinal stimulation
    Saiful A Joarder
    Faculty of Engineering, University of Newcastle, Callaghan, NSW 2038, Australia
    Conf Proc IEEE Eng Med Biol Soc 2007:1132-5. 2007
    ..Model threshold values were some 2-5 times higher than that of the experimental values...
  14. ncbi Effects of gonadal steroids on the input-output relationship of the corticospinal pathway in humans
    Marco Bonifazi
    Dipartimento di Fisiologia, Universita degli Studi di Siena, 53100, Siena, Italy
    Brain Res 1011:187-94. 2004
    ..Our observations confirm that the threshold and gain of corticospinal motoneurones are determined by different neural mechanisms...
  15. ncbi Subtle hemispheric asymmetry of motor cortical inhibitory tone
    Tihomir V Ilic
    Clinic of Neurology, J W Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Clin Neurophysiol 115:330-40. 2004
    ..To test whether a novel paired transcranial magnetic stimulation (TMS) protocol (J Physiol 545.1 (2002) 153) detects hemispheric differences in motor cortical inhibition...
  16. ncbi Acute and chronic effects of ethanol on cortical excitability
    A Conte
    Department of Neurological Sciences, University of Rome Sapienza, Viale dell Universita, 30, 00185, Rome, Italy
    Clin Neurophysiol 119:667-74. 2008
    ..We designed this study to find out whether 5Hz repetitive transcranial magnetic stimulation (rTMS) would disclose changes in cortical plasticity after acute intake of ethanol and in patients with chronic alcohol consumption...
  17. ncbi Modulation of motor cortical excitability following rapid-rate transcranial magnetic stimulation
    Eman M Khedr
    Department of Neurology, Assiut University Hospital, Assiut, Egypt
    Clin Neurophysiol 118:140-5. 2007
    ..To investigate the effect of high frequency rTMS (25 Hz at 90-100% of resting motor threshold) on the excitability of the motor cortex of healthy human subjects...
  18. pmc Repetitive firing of rat cerebellar parallel fibres after a single stimulation
    Philippe Isope
    Laboratoire de Physiologie Cérébrale, UMR CNRS 8118, Centre Universitaire des Saints Peres, 45 Rue des Saints Peres, 75006 Paris, France
    J Physiol 554:829-39. 2004
    ..The repetitive activation of the PF by a single stimulation could play a role in the induction of long-term depression...
  19. ncbi Further evidence that a shared efferent collicular pathway drives separate circuits for smooth eye movements and saccades
    M Missal
    Laboratory of Neurophysiology, School of Medicine, Universite Catholique de Louvain, 5449 Ave Hippocrate, 1200 Brussels, Brussels, Belgium
    Exp Brain Res 147:344-52. 2002
    ..We suggest that the same collicular efferent cells carry out the motor command to saccadic and SEM circuits and that the position error originating from the SC may be distributed amongst separate downstream motor systems...
  20. ncbi Synchronization of electrically coupled pairs of inhibitory interneurons in neocortex
    Jaime G Mancilla
    Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 27:2058-73. 2007
    ..Electrical coupling between cortical interneurons of the same type maintained robust synchronous firing of cell pairs for up to approximately 10% heterogeneity in their intrinsic frequencies...
  21. pmc Ca2+ imaging of mouse neocortical interneurone dendrites: contribution of Ca2+-permeable AMPA and NMDA receptors to subthreshold Ca2+dynamics
    Jesse H Goldberg
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    J Physiol 551:67-78. 2003
    ..These data highlight different strategies in dendritic signal processing by distinct classes of interneurones...
  22. ncbi Slow frequency repetitive transcranial magnetic stimulation affects reaction times, but not priming effects, in a masked prime task
    F Schlaghecken
    Department of Psychology, University of Warwick, Coventry CV4 7AL, UK
    Clin Neurophysiol 114:1272-7. 2003
    ..Slow frequency repetitive transcranial magnetic stimulation (rTMS) reduces motor cortex excitability, but it is unclear whether this has behavioural consequences in healthy subjects...
  23. ncbi Frequency-dependent, bi-directional plasticity in motor cortex of human adults
    Julia B Pitcher
    Department of Physiology, The University of Adelaide, Adelaide, SA 5005, Australia
    Clin Neurophysiol 114:1265-71. 2003
    ..To determine whether the plastic changes induced in human motor cortex by afferent stimulation depend on stimulus frequency...
  24. ncbi Construction of a computer model to investigate sawtooth effects in the Purkinje system
    Edward J Vigmond
    Department of Electrical and Computer Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada
    IEEE Trans Biomed Eng 54:389-99. 2007
    ..Thus, the Purkinje system is capable of affecting the defibrillation process, and warrants further experimentation to elucidate its role...
  25. ncbi Effects of 5 Hz subthreshold magnetic stimulation of primary motor cortex on fast finger movements in normal subjects
    R Agostino
    Department of Neurological Sciences and Neuromed Institute, University of Rome La Sapienza, Viale dell Universita, 30, 00185 Rome, Italy
    Exp Brain Res 180:105-11. 2007
    ..Since motor behaviour engages a distributed cortical and subcortical neuronal network, excitatory conditioning of the primary motor cortex is probably not sufficient to influence the behavioural output...
  26. ncbi Neurophysiological study of corticomotor pathways in restless legs syndrome
    R Quatrale
    Department of Neurology, S Anna Hospital, University of Ferrara, C so Giovecca, 203 I 44100 Ferrara, Italy
    Clin Neurophysiol 114:1638-45. 2003
    ..Moreover, in primary RLS, these modifications are still debated...
  27. ncbi Cortical correlates of neuromotor development in healthy children
    M A Garvey
    Pediatric Movement Disorders Unit, Human Motor Control Section, Motor Neurology Branch, NINDS, National Institutes of Health, 10 Center Drive, 5N226, MSC 1428, Bethesda, MD 20982 1428, USA
    Clin Neurophysiol 114:1662-70. 2003
    ..To examine the relationship between acquisition of fine motor skills in childhood and development of the motor cortex...
  28. pmc Ketamine increases human motor cortex excitability to transcranial magnetic stimulation
    V Di Lazzaro
    Institute of Neurology, Universita Cattolica, Largo A Gemelli 8, 00168 Rome, Italy
    J Physiol 547:485-96. 2003
    ..We suggest that the enhancement of human motor cortex excitability to transcranial magnetic stimulation is the effect of an increase in glutamatergic transmission at non-NMDA receptors similar to that described in experimental studies...
  29. ncbi Dipole distance for minimum threshold current to stimulate unmyelinated axons with microelectrodes
    Frank Rattay
    Institute for Analysis and Scientific Computing at the Vienna University of Technology, Wiedner Hauptstr 8 10 101, A 1040 Vienna, Austria
    IEEE Trans Biomed Eng 54:158-62. 2007
    ..Spike initiations in straight fibers and retinal ganglion cell axons are investigated...
  30. ncbi Suprathreshold 0.3 Hz repetitive TMS prolongs the cortical silent period: potential implications for therapeutic trials in epilepsy
    M Cincotta
    Unita Operativa di Neurologia, Azienda Sanitaria di Firenze, Ospedale S Maria Nuova, Piazza S Maria Nuova, 1 50122, Florence, Italy
    Clin Neurophysiol 114:1827-33. 2003
    ..To investigate the after-effects of 0.3 Hz repetitive transcranial magnetic stimulation (rTMS) on excitatory and inhibitory mechanisms at the primary motor cortex level, as tested by single-pulse TMS variables...
  31. pmc Mathematical models of cochlear nucleus onset neurons: I. Point neuron with many weak synaptic inputs
    Sridhar Kalluri
    Harvard University Massachusetts Institute of Technology, Division of Health Sciences and Technology, Eaton Peabody Lab, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Comput Neurosci 14:71-90. 2003
    ..These results show a tradeoff, that may be a general property of many neurons, between following rapid stimulus fluctuations and responding without short interspike intervals at the onset of sustained stimuli...
  32. pmc Short-interval paired-pulse inhibition and facilitation of human motor cortex: the dimension of stimulus intensity
    Tihomir V Ilic
    Clinic of Neurology, Johann Wolfgang Goethe University of Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    J Physiol 545:153-67. 2002
    ..In contrast, SICF originates through non-synaptic facilitation at the initial axon segment of interneurones along a high-threshold excitatory pathway...
  33. ncbi Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5 Hz repetitive TMS to the primary motor cortex
    Alexander Peinemann
    Department of Neurology, Technische Universitat Munchen, Mohlstrasse 28, D 81675 Munich, Germany
    Clin Neurophysiol 115:1519-26. 2004
    ..To study the after effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) on corticospinal excitability...
  34. ncbi Effect of muscle-fiber velocity recovery function on motor unit action potential properties in voluntary contractions
    Dario Farina
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7 D 3, DK 9220 Aalborg, Denmark
    Muscle Nerve 37:650-8. 2008
    ..This has implications for the use of conduction velocity values measured during voluntary contractions to differentiate patient populations from healthy individuals and for the development of normative data...
  35. ncbi The most likely voltage path and large deviations approximations for integrate-and-fire neurons
    Liam Paninski
    Department of Statistics, Columbia University, Columbia
    J Comput Neurosci 21:71-87. 2006
    ..We close by comparing this most likely voltage path to the true observed subthreshold voltage trace in a case when intracellular voltage recordings are available in vitro...
  36. ncbi Conduction velocity of quiescent muscle fibers decreases during sustained contraction
    Marco Gazzoni
    Laboratorio di Ingegneria del Sistema Neuromusculore, Dipartimento di Elettronica, Politecnico di Torino, Torino, Italy
    J Neurophysiol 94:387-94. 2005
    ..6 +/- 5.4%). In conclusion, the contraction-induced modifications in electrophysiological membrane properties of muscle fibers are partly independent on fiber activation...
  37. ncbi Magnetic stimulation of curved nerves
    A Rotem
    A Rotem is with the Weizmann Institute of Science, PO Box 26, Rehovot 76100 Israel
    IEEE Trans Biomed Eng 53:414-20. 2006
    ..In the experimental section, we show that magnetic stimulation of the frog sciatic nerve follows our theoretical predictions. Furthermore, the voltage length constant of the nerve can be measured based on these results alone...
  38. ncbi Orderly activation of human motor neurons using electrical ramp prepulses
    Kristian Hennings
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Frederik Bajers Vej 7 D3 203, 9220 Aalborg, Denmark
    Clin Neurophysiol 116:597-604. 2005
    ..The present study investigated the possibility for changing the recruitment order of electrical stimuli with sub-threshold ramp prepulses...
  39. ncbi Corticomotor organisation and motor function in multiple sclerosis
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders M518, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands, WA 6009, Australia
    J Neurol 252:765-71. 2005
    ..An understanding of motor function in MS should incorporate models of both axonal demyelination and conduction deficits as well as neural plasticity...
  40. pmc Asynchronous inputs alter excitability, spike timing, and topography in primary auditory cortex
    Pritesh K Pandya
    Neuroscience Program, School of Behavioral and Brain Sciences, PO Box 830688, GR 41, University of Texas at Dallas, Richardson, TX 75083 0688, USA
    Hear Res 203:10-20. 2005
    ..These results are consistent with earlier observations that sensory input statistics can shape cortical map organization and spike timing...
  41. ncbi Predicting dynamic range and intensity discrimination for electrical pulse-train stimuli using a stochastic auditory nerve model: the effects of stimulus noise
    Yifang Xu
    Department of Electrical and Computer Engineering, Duke University, Durham, NC 27708 0291, USA
    IEEE Trans Biomed Eng 52:1040-9. 2005
    ..However, since our predictions indicate that intensity discrimination under noise degrades, overall intensity coding performance may not improve significantly...
  42. ncbi Marked differences in the thermal characteristics of figure-of-eight shaped coils used for repetitive transcranial magnetic stimulation
    Thomas Weyh
    Heinz Nixdorf Lehrstuhl für Medizinische Elektronik, Technische Universitat Munchen, Arcisstrasse 21, 80333 Munich, Germany
    Clin Neurophysiol 116:1477-86. 2005
    ..To compare the heating behaviour of three figure-of-eight shaped coils during repetitive transcranial magnetic stimulation (rTMS)...
  43. ncbi Repetitive paired-pulse TMS at I-wave periodicity markedly increases corticospinal excitability: a new technique for modulating synaptic plasticity
    Gary W Thickbroom
    Centre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, University of Western Australia, Perth, Nedlands, WA 6009, Australia
    Clin Neurophysiol 117:61-6. 2006
    ..Our objective was to determine whether prolonged iTMS can increase corticospinal excitability, and whether this form of stimulation can have lasting aftereffects...
  44. ncbi Physiology of modulation of motor cortex excitability by low-frequency suprathreshold repetitive transcranial magnetic stimulation
    G Heide
    Department of Neurology, Friedrich Schiller University, Erlanger Allee 101, 07740 Jena, Germany
    Exp Brain Res 171:26-34. 2006
    ..Modulation of motor cortical inhibition did not play a role in explaining the rTMS induced changes in MEP amplitude...
  45. ncbi Dynamic-clamp analysis of the effects of convergence on spike timing. II. Few synaptic inputs
    Matthew A Xu-Friedman
    Department of Biological Sciences, University at Buffalo, State University of New York, USA
    J Neurophysiol 94:2526-34. 2005
    ..These significant differences indicate that each means of reducing jitter has advantages and disadvantages and may be more effective for different neurons depending on the properties of their inputs...
  46. ncbi Pathways mediating abnormal intracortical inhibition in Parkinson's disease
    Colum D MacKinnon
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ann Neurol 58:516-24. 2005
    ..These findings show that the low threshold inhibitory pathways mediating SICI are normal in PD. The suppression of SICI observed at higher CSIs suggests that the threshold of intracortical facilitatory pathways is decreased in PD...
  47. ncbi Predicting spike timing of neocortical pyramidal neurons by simple threshold models
    Renaud Jolivet
    Ecol Polytechnique Federale de Lausanne EPFL, School of Computer and Communication Sciences and Brain Mind Institute, Station 15, CH 1015, Lausanne, Switzerland
    J Comput Neurosci 21:35-49. 2006
    ....
  48. ncbi Stimulus-response curves of a neuronal model for noisy subthreshold oscillations and related spike generation
    Martin Tobias Huber
    Department of Psychiatry and Psychotherapy, University of Marburg, Rudolf Bultmannstrasse 8, D 35033 Marburg, Germany
    Phys Rev E Stat Nonlin Soft Matter Phys 73:041929. 2006
    ..We demonstrate that subthreshold oscillatory neurons in the presence of noise can sensitively and also selectively be tuned by the stimulus-dependent variation of model parameters...
  49. ncbi Preconditioning with transcranial direct current stimulation sensitizes the motor cortex to rapid-rate transcranial magnetic stimulation and controls the direction of after-effects
    Nicolas Lang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Biol Psychiatry 56:634-9. 2004
    ....
  50. ncbi Cortical silent period prolongation in spinocerebellar ataxia type 2 (SCA2)
    Domenico A Restivo
    Department of Neurology, Garibaldi Hospital, Catania, Italy
    Funct Neurol 19:37-41. 2004
    ..Thus, the cerebellum seems to exert a pliable physiological influence on the cortico-spinal system through control of inhibitory cortical interneurons...
  51. ncbi A novel electrode array for diameter-dependent control of axonal excitability: a simulation study
    Zeng Lertmanorat
    Neural Engineering Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    IEEE Trans Biomed Eng 51:1242-50. 2004
    ..The diameter selectivity of the electrode array can be controlled by the electrode separation and the method is independent of pulse width...
  52. ncbi A single motor unit recording technique for studying the differential activation of corticospinal volleys by transcranial magnetic stimulation
    Y Terao
    Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan
    Brain Res Brain Res Protoc 7:61-7. 2001
    ..The obtained results accord well with recent epidural recording studies, which lends support to the validity of this method...
  53. ncbi Phasic stimuli evoke precisely timed spikes in intermittently discharging mitral cells
    Ramani Balu
    Dept of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Neurophysiol 92:743-53. 2004
    ..These intrinsic properties of mitral cells may be important for precisely timing spikes evoked by phasic stimuli that occur in response to odor presentation in vivo...
  54. ncbi Focal transcranial magnetic stimulation of motor cortex evokes bilateral and symmetrical silent periods in human masseter muscles
    Shapour Jaberzadeh
    Discipline of Physiology, School of Molecular and Biomedical Sciences, The University of Adelaide, Adelaide, SA 5005, Australia
    Clin Neurophysiol 119:693-703. 2008
    ....
  55. ncbi Corticospinal system excitability at rest is associated with tic severity in tourette syndrome
    Michael Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Biol Psychiatry 64:248-51. 2008
    ..However, it is not clear whether these represent abnormalities of specific pathways or reflect a more widespread reduction of motor cortex excitability. Their significance for the clinical phenotype is also unknown...
  56. ncbi Effect of levetiracetam on cortical excitability: a transcranial magnetic stimulation study
    C Solinas
    Southern Clinical School, Monash University, Clayton, Vic, Australia
    Eur J Neurol 15:501-5. 2008
    ..For this purpose, 38 healthy volunteers were assessed in two TMS sessions, before and after an oral dose of 3000 mg LEV...
  57. ncbi Comparative assessment of best conventional with best theta burst repetitive transcranial magnetic stimulation protocols on human motor cortex excitability
    Noman Zafar
    Department of Clinical Neurophysiology, University of Gottingen, Robert Koch Street 40, 37075 Gottingen, Germany
    Clin Neurophysiol 119:1393-9. 2008
    ..Comparative assessment of best conventional with best theta burst repetitive transcranial magnetic stimulation (rTMS) protocols on human motor cortex excitability...
  58. ncbi Afterhyperpolarization time-course and minimal discharge rate in low threshold motor units in humans
    Christopher W MacDonell
    Graduate Program in Neuroscience, University of Western Ontario, London, ON, Canada
    Exp Brain Res 189:23-33. 2008
    ..The calculated AHP time course using the IDR analysis, therefore, is a reasonable estimate and coupled with motor unit properties attained with STA, it provides a powerful method to describe low-threshold motor units...
  59. ncbi Estimating action potential thresholds from neuronal time-series: new metrics and evaluation of methodologies
    Murat Sekerli
    Laboratory for Neuroengineering and the School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0250, USA
    IEEE Trans Biomed Eng 51:1665-72. 2004
    ..Our user database of responses may be useful to other investigators interested in developing additional methods in that it quantifies what has often been a subjective estimate...
  60. ncbi Quantification of the corticospinal silent period evoked via transcranial magnetic stimulation
    Leatha A Damron
    Department of Physical Therapy, SUNY Upstate Medical University, United States
    J Neurosci Methods 173:121-8. 2008
    ..These results suggest that SPs evoked with a stimulus intensity >or=30% AMT and quantified visually by defining the start of the SP at stimulus delivery or the start of the MEP be utilized to decrease the between visit variability...
  61. ncbi Distal excitability changes in motor axons in amyotrophic lateral sclerosis
    Miho Nakata
    Department of Neurology, Graduate School of Medicine, Chiba University, 1 8 1, Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Clin Neurophysiol 117:1444-8. 2006
    ..This study tested the hypothesis that dysfunction of potassium channels is more pronounced in the more distal parts of axons...
  62. ncbi Correspondence between the location of evoked potential generators and sites of maximal sensitivity to stimulation
    Mark M Stecker
    Department of Neurology, Geisinger Medical Center, Danville, PA 17822, USA
    IEEE Trans Biomed Eng 52:1619-21. 2005
    ..This allows the identification of the point at which an action potential generates a maximal extracellular potential as the point that is stimulated with the lowest threshold...
  63. ncbi Multistage evaluation scale, differential threshold steps and equivalent sensation contours of respiratory flow-resistive load sensation
    L F Zhang
    Department of Aviation Environmental Physiology, Fourth Military Medical College, Xi an
    Sci Sin B 31:204-16. 1988
    ..In brief, we have proposed a new way to elucidate the physiological and psychophysical effects of various added resistive loads...
  64. ncbi Dual-energy CT in the diagnosis and quantification of fatty liver: limited clinical value in comparison to ultrasound scan and single-energy CT, with special reference to iron overload
    M H Mendler
    Department of Gastroenterology, Dupuytren University Hospital, Limoges, France
    J Hepatol 28:785-94. 1998
    ..We compared dual-energy CT to ultrasound scan and single-energy CT in the diagnosis and quantification of fatty liver, with special reference to iron overload...
  65. ncbi An evaluation of acrylic complete dentures using the discrimination of elastic bodies or viscous fluids
    K Inoue
    Department of Dental Materials Science, Kagoshima University Dental School, Japan
    J Oral Rehabil 26:608-12. 1999
    ..This indicates that with an increase in the area occupied by dentures in the oral cavity, the value of the differential threshold increased markedly and made food discrimination more difficult...
  66. ncbi Age-dependent normative values for differential luminance sensitivity in automated static perimetry using the Octopus 101
    Agnes Hermann
    Centre for Ophthalmology, University of Tubingen, Tubingen, Germany
    Acta Ophthalmol 86:446-55. 2008
    To determine age-dependent normative differential threshold values for the Octopus 101 instrument and to create a smooth mathematical model characterizing the age-dependency and asymmetry of the hill of vision.
  67. pmc Accuracy of popular automatic QT interval algorithms assessed by a 'gold standard' and comparison with a Novel method: computer simulation study
    Anthony Charles Hunt
    PSI HeartSignals Ltd, Institute of Medical Technology, Glasgow Technology Park, PO Box 7043, Glasgow G44 9AB, UK
    BMC Cardiovasc Disord 5:29. 2005
    ..There is a scientific imperative to evaluate the most commonly used algorithms with an accurate and objective 'gold standard' and investigate novel automatic algorithms if the commonly used algorithms are found to be deficient...
  68. ncbi Differential threshold of length and response criterion for inspecting irregular objects
    C F Chi
    Department of Industrial Management, National Taiwan University of Science and Technology, Taipei
    Percept Mot Skills 85:723-35. 1997
    ..The standard deviation of the signal distribution was about 1.30 and 1.41 times that of the noise distributions for 'low' and 'high' detectability...
  69. ncbi Impact of hyperventilation on stimulus efficiency during the early phase of an electroconvulsive therapy course: a randomized double-blind study
    Prashanth Mayur
    Department of Psychiatry, Cumberland Hospital, Sydney, Australia
    J ECT 26:91-4. 2010
    ..The question whether hyperventilation during electroconvulsive therapy (ECT) can improve stimulus efficiency is as yet unanswered...
  70. ncbi Differential threshold effects of habitat fragmentation on gene flow in two widespread species of bush crickets
    Rebecca Lange
    Department of Animal Ecology, Justus Liebig University, Heinrich Buff Ring 26 32, D 35392 Giessen, Germany
    Mol Ecol 19:4936-48. 2010
    ..These results indicate that even for widespread species in modern agricultural landscapes fragmentation thresholds exist at which gene flow among suitable habitat patches becomes restricted...
  71. ncbi Unification of psychophysical phenomena: the complete form of Fechner's law
    K H Norwich
    Department of Physiology, University of Toronto, ON, Canada
    Percept Psychophys 59:929-40. 1997
    ..triplets of quantities: subjective magnitude of stimulus, subjective just noticeable difference (jnd), and differential threshold. Each of the preceding quantities are functions of the physical magnitude of the stimulus...
  72. ncbi Predominant involvement of a particular group of fingers due to small, cortical infarction
    J S Kim
    Department of Neurology, University of Ulsan, Asan Medical Center, Seoul, Korea
    Neurology 56:1677-82. 2001
    ..Small cortical strokes may cause predominant weakness restricted to a particular group of fingers. However, clinical, radiologic, and etiopathogenetical studies have rarely been done in these patients...
  73. ncbi Neohesperidin dihydrochalcone is not a taste enhancer in aqueous sucrose solutions
    J H Kroeze
    Psychological Laboratory, Utrecht University, Utrecht, The Netherlands and Wageningen Taste and Smell Center, Wageningen University, Wageningen, The Netherlands
    Chem Senses 25:555-9. 2000
    ..Finally, in experiment 4, differential threshold functions were constructed with either NHDC or sucrose added...
  74. ncbi Central visual field impairment during and following cystoid macular oedema
    C G Kiss
    Department of Ophthalmology and Optometry at the Medical University of Vienna, Vienna, Austria
    Br J Ophthalmol 92:84-8. 2008
    ..To determine differential light threshold values obtained with the Micro Perimeter 1 (MP1) in uveitis patients suffering from cystoid macular oedema (CMO) and to compare these measures to retinal thickness...
  75. ncbi [Study on resistance to motion artifact in pulse oximetry measurement using segment filter method]
    Qing Bo Li
    Key Laboratory of Precision Opto Mechatronics Technology, Ministry of Education, College of Instrument Science and Opto Electronics Engineering, Beihang University, Beijing 100191, China
    Guang Pu Xue Yu Guang Pu Fen Xi 29:2994-7. 2009
    The authors proposed a method which combined the differential threshold segment with median filter to eliminate abrupt artifact motion interference in the use of pulse oximeter, and further more, by adding the window moving average filter,..
  76. ncbi Stress sensitization and adolescent depressive severity as a function of childhood adversity: a link to anxiety disorders
    Emmanuel P Espejo
    Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA
    J Abnorm Child Psychol 35:287-99. 2007
    The goal of the present study was to determine whether exposure to adversity in childhood contributes to a differential threshold at which stressful life events provoke depressive reactions in adolescence...
  77. ncbi Impaired short temporal interval discrimination in a dyslexic adult
    L Rousseau
    Department of Psychology, Laurentian University, Sudbury, Ontario, Canada
    Brain Cogn 46:249-54. 2001
    ..Eight target intervals were used, ranging from 100 to 1,200 ms in duration. At each target interval, the differential threshold (DL) for duration was assessed, with the use of an adaptive psychophysical procedure...
  78. ncbi A novel algorithm for precise identification of spikes in extracellularly recorded neuronal signals
    Alessandro Maccione
    Department of Neuroscience and Brain Technology, Italian Institute of Technology, Via Morego 30, 16163 Genova, Italy
    J Neurosci Methods 177:241-9. 2009
    ..of the signal and looks for the Relative Maximum/Minimum whose peak-to-peak amplitude is above a defined differential threshold and responds to specific requirements...
  79. ncbi Repression of Dpp targets in the Drosophila wing by Brinker
    Stephanie E Winter
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Development 131:6071-81. 2004
    ..Understanding differential threshold responses requires knowledge of how these factors regulate transcription...
  80. ncbi [General indications of middle-ear implants]
    Angel Osorio Acosta
    Servicio de Otorrinolaringologia, Complejo Hospitalario Universitario Materno Infantil de Gran Canaria, Las Palmas de Gran Canaria, Espana
    Acta Otorrinolaringol Esp 59:14-6. 2008
    ..The differential threshold in frequencies of 500, 1,000, 2,000 and 4,000 Hz should not be above 10 dB in two or more of these ..
  81. pmc Stochastic probability landscape model for switching efficiency, robustness, and differential threshold for induction of genetic circuit in phage lambda
    Youfang Cao
    Shanghai Center for Systems Biomedicine, Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
    Conf Proc IEEE Eng Med Biol Soc 2008:611-4. 2008
    ..Our study has revealed likely mechanism of the phage switch network that was previously unknown...
  82. ncbi The physiological basis of transcranial motor cortex stimulation in conscious humans
    V Di Lazzaro
    Institute of Neurology, Universita Cattolica, Largo A Gemelli 8, 00168, Rome, Italy
    Clin Neurophysiol 115:255-66. 2004
    ..These differences occur because different structures in the motor cortex have a differential threshold to the different techniques of stimulation...
  83. ncbi [Threshold values for cost-effectiveness ratio and public funding of medical technologies]
    Mordechai Rabinovich
    Maccabi Healthcare Services, Tel Aviv, Israel
    Harefuah 146:453-8, 500. 2007
    ..There are several suggestions to set a differential threshold value between countries, associated with their relative wealth, or between diverse disease and treatment ..
  84. ncbi Effect of the moderate exercise on performance in upper/lower limb during long term bed rest
    Masami Miyazaki
    Waseda University, Tokorozawa Japan
    J Gravit Physiol 9:P147-8. 2002
    ..And then there were not change discriminal ability on differential threshold of weight sensory in scale test in all subjects during head down bed rest...
  85. ncbi Characteristics and mechanisms of the two types of photoelectric differential response of bacteriorhodopsin-based photocell
    Baoli Yao
    State Key Laboratory of Transient Optics Technology, Xi an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, PO Box 80 25, Xi an710068, P R China
    Biosens Bioelectron 19:283-7. 2003
    ..It was much faster but much weaker than that described before...
  86. ncbi Permitted and forbidden sets in symmetric threshold-linear networks
    Richard H R Hahnloser
    Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, MIT E25 210, Cambridge, MA 02139, U S A
    Neural Comput 15:621-38. 2003
    ..There is a close correspondence between threshold-linear networks and networks defined by the generalized Lotka-Volterra equations...
  87. pmc Mathematical models of cochlear nucleus onset neurons: II. model with dynamic spike-blocking state
    Sridhar Kalluri
    Harvard University Massachusetts Institute of Technology, Division of Health Sciences and Technology, Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Comput Neurosci 14:91-110. 2003
    ..These results provide a mechanistic rationale for distinguishing between the different physiological classes of CN On neurons...
  88. ncbi [Function of TRP channel as a thermal receptor]
    Makoto Tominaga
    Nihon Seirigaku Zasshi 65:130-7. 2003
  89. ncbi [Is the determination of the defibrillation threshold in patients with an implantable cardioverter-defibrillator still required?]
    M Licka
    Abteilung fur Kardiologie, Angiologie und Pneumologie, Universitatsklinikum Heidelberg, Heidelberg, Germany
    Herzschrittmacherther Elektrophysiol 22:209-13. 2011
    ....
  90. ncbi Maturational changes of 5 Hz SSVEPs elicited by intermittent photic stimulation
    Ala Birca
    Research Center, Centre Hospitalier Universitaire Mère Enfant Sainte Justine, Universite de Montreal, Montreal, QC, Canada
    Int J Psychophysiol 78:295-8. 2010
    ..We interpret these findings in terms of the development of functional interactions between different cortical areas involved in the processing of visual stimuli...
  91. pmc Microperimetry and fundus autofluorescence in patients with early age-related macular degeneration
    Edoardo Midena
    Department of Ophthalmology, University of Padova, Via Giustiani 2, 35128 Padova, Italy
    Br J Ophthalmol 91:1499-503. 2007
    ..The aim of this study was to compare fundus-related sensitivity (microperimetry) and fundus autofluorescence (FAF) of the macular area with drusen and pigment abnormalities in early AMD...
  92. pmc Influence of subthreshold nonlinearities on signal-to-noise ratio and timing precision for small signals in neurons: minimal model analysis
    Gytis Svirskis
    Center for Neural Science, New York University, NY 10003, USA
    Network 14:137-50. 2003
    ..Small-signal detection can be significantly improved in noisy neuronal systems by subthreshold negative feedback, serving to suppress false positives...
  93. ncbi Spatial frequency thresholds for face recognition when comparison faces are filtered and unfiltered
    Charles A Collin
    School of Psychology, University of Ottawa, Ottawa, Ontario, Canada
    Percept Psychophys 68:879-89. 2006
    ..These results are compatible with the idea that a middle band of SFs will be most useful for any visual task and that the breadth of this optimal middle band will vary depending on task characteristics...
  94. ncbi Stochastic resonance in neuron models: endogenous stimulation revisited
    H E Plesser
    Max Planck Institut für Strömungsforschung and Fakultät für Physik, Universitat Gottingen, Germany
    Phys Rev E Stat Nonlin Soft Matter Phys 63:031916. 2001
    ..This greatly simplifies the mathematical analysis, but we show that stochastic resonance as reported earlier occurs in this model only as a consequence of the reduced dynamics...
  95. ncbi The judgment operation of ratio production
    Sergio Cesare Masin
    Department of General Psychology, Universita di Padova, Padua, Italy
    Percept Psychophys 69:1-8. 2007
    ..It was found that this added amount varied nonlinearly with the predefined ratio, implying that ratio productions are nonlinear...
  96. ncbi On the mechanism of the probabilistic nature of ventricular defibrillation threshold
    Masaaki Yashima
    Division of Cardiology, Cedars Sinai Medical Center, Department of Medicine, School of Medicine, University of California, Los Angeles 90048, USA
    Am J Physiol Heart Circ Physiol 284:H249-55. 2003
    ..We conclude that the probabilistic nature of the DFT is related to the amount of myocardium in its VP...
  97. ncbi [Evaluation of adhesive tape containing lidocaine using current perception threshold measurement]
    A Egi
    Department of Anesthesia and Intensive Care, Hiroshima City Asa Hospital, Hiroshima 731-0293
    Masui 50:731-5. 2001
    ..However, CPT levels tended to decrease 12 hours after application, regardless of the stimulus rate. From the result, we conclude that Penles provides maximum benefit when applied 6 hours prior to vein puncture...
  98. pmc Electrophysiological and morphological properties of pre-autonomic neurones in the rat hypothalamic paraventricular nucleus
    J E Stern
    Department of Pharmacology and Toxicology, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    J Physiol 537:161-77. 2001
    ....
  99. ncbi Extracellular stimulation of mouse retinal ganglion cells with non-rectangular voltage-controlled waveforms
    Donald R Cantrell
    Northwestern University Interdepartmental Neuroscience Program, Northwestern University, Evanston, IL 60208 USA
    Conf Proc IEEE Eng Med Biol Soc 2009:642-5. 2009
    ..Also, the suprathreshold Gaussian and sinusoidal waveforms possessed much lower peaks in current. For this reason, these non-rectangular waveforms may be useful in reducing electrode corrosion and tissue damage...
  100. ncbi Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression
    Neal Lemon
    Learning and Memory Research, Medical Faculty, and International Graduate School for Neuroscience, Ruhr University Bochum, 44780 Bochum, Germany
    J Neurosci 26:7723-9. 2006
    ..These findings suggest that the dopaminergic system, acting via D1/D5 receptors, gates long-term changes in synaptic strength and that these changes are a critical factor in the acquisition of novel information...
  101. ncbi A randomized comparison of defibrillation thresholds in the right ventricular outflow tract versus right ventricular apex
    Michael Mollerus
    St Mary s Duluth Clinic, Duluth, MN 55805, USA
    J Interv Card Electrophysiol 22:221-5. 2008
    ..To determine whether the placement of an implantable cardioverter-defibrillator (ICD) lead in the right ventricular outflow tract (RVOT) has the same defibrillation threshold (DFT) as the right ventricular apex (RVA)...

Research Grants67

  1. Recovery of motoneuron excitability after spinal injury
    Monica A Gorassini; Fiscal Year: 2010
    ..Once known, then rehabilitative and/or pharmacological interventions that target motoneuron transduction processes can be developed. ..
  2. Arrhythmia Assessment Core Lab for IMMEDIATE Trial
    Eric Rashba; Fiscal Year: 2006
    ..End of abstract.) [unreadable] [unreadable]..
  3. Electrophysiologic effects of late PCI (OAT-EP)
    Stephen Shorofsky; Fiscal Year: 2005
    ....
  4. Prognostic significance of T wave variability
    Eric Rashba; Fiscal Year: 2006
    ..2) Patients with increased T wave variability derive a greater mortality benefit from prophylactic ICD implantation. ..
  5. Peripheral Visual Function of Children with Low Vision
    JOSEPH LAPPIN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  6. Assessment and Validation of Tongue Fatigue for Speech
    NANCY SOLOMON; Fiscal Year: 2004
    ..This aim will provide evidence to support the clinical relevance of the exacerbation of dysarthria by fatigue and further validate the constant-effort technique as an indicator of fatigue. ..
  7. Visual Dysfunction in Retinal Degenerations
    Kenneth R Alexander; Fiscal Year: 2010
    ....
  8. Dendodendritic computation in the olfactory glomerulus
    THOMAS CLELAND; Fiscal Year: 2004
    ..abstract_text> ..
  9. Elevated Tendency to Appraise Events as Stressful in the Risk for Depression and
    EMMANUEL ESPEJO; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. The Effects of Resveratrol on Presbyacusis
    Michael Seidman; Fiscal Year: 2004
    ..Furthermore, these data will provide novel strategies to impart greater wellness in the elderly population and perhaps have a positive effect on health care expenses. ..
  11. Computational mechanisms in the olfactory bulb
    THOMAS CLELAND; Fiscal Year: 2008
    ..Quantitative, integrative results such as these are unlikely to be achieved without the use of computational modeling. ..
  12. Transducer for indirect blood pressure& O2 saturation
    Leslie Geddes; Fiscal Year: 2005
    ..The neonatologist, the premature infant physician and the small-infant pediatrician have no single instrument that provides all of these vital signs. ..
  13. Gene Therapy of Autosomal Recessive RP
    Simon Petersen Jones; Fiscal Year: 2006
    ..abstract_text> ..
  14. Crosstalk of hypocretin and MCH in feeding regulation
    Xiao Bing Gao; Fiscal Year: 2010
    ..Ultimately, we hope that our research will benefit those suffering from obesity and obesity-related diseases. ..
  15. SEX HORMONES AND BODY FLUID REGULATION
    NINA STACHENFELD; Fiscal Year: 2003
    ....
  16. PHYSIOLOGY OF VOCALIZATION SEN IN AUDITORY CORTEX
    MARK TRAMO; Fiscal Year: 2002
    ....
  17. Development of Motion Processing in Human Infants
    Karen Dobkins; Fiscal Year: 2008
    ..abstract_text> ..
  18. PKC modulation of calcium current and anesthetic action
    GANESAN KAMATCHI; Fiscal Year: 2007
    ..abstract_text> ..
  19. Hypnotics and the Treatment of Psychiatric Disorders
    WILLIAM MCCALL; Fiscal Year: 2007
    ..abstract_text> ..
  20. Physiological Studies of Age-Related Hearing Loss
    RICHARD SCHMIEDT; Fiscal Year: 2007
    ..Taken together, the three aims explore the major causes and effects of metabolic presbyacusis and have direct application to future interventions to help restore age-related hearing loss. [unreadable] [unreadable]..
  21. Principles of Behavior Change: Choice and Context
    Edmund Fantino; Fiscal Year: 2010
    ..The outcomes of these studies are expected to influence the development of improved and individualized forms of behavioral and cognitive therapy as well as guide future research on the neural bases of choice. ..
  22. Sound Source Segregation and Determination
    Richard Fay; Fiscal Year: 2007
    ..We will focus on understanding the dimensions of neural activity that the brain could use in segregating and integrating simultaneous acoustic components from one or more sources. [unreadable] [unreadable]..
  23. Information processing at auditory nerve synapses
    Matthew A Xu Friedman; Fiscal Year: 2011
    ..This work may lead to improvements both in existing cochlear implants and in implants that stimulate the cochlear nucleus directly. ..
  24. Imprint Osmoregulation/Maternally-Dehydrated Offspring
    Mina Desai; Fiscal Year: 2007
    ..We will determine the molecular and cellular mechanism(s) and peripheral renal AVP receptor changes. Finally, we will delineate the critical period during which imprinting of the AVP/osmoregulatory pathway occurs. ..
  25. Auditory nerve responses to electric pulse trains
    Charles Miller; Fiscal Year: 2009
    ..We expect the results of this work will guide future designs of cochlear-implant speech processors so that modulated stimuli can be better tailored to the encoding capacity of the user's auditory nerve. ..
  26. Computational Methods for Fine Mapping
    Paul Marjoram; Fiscal Year: 2007
    ..Bayes methods, which abstract out the effects of the genealogy using hierarchical clustering techniques. ..
  27. Sound Source Segregation and the Cocktail Party Problem in a Non-human Vertebrate
    MARK BEE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Origins of Binaural Processing in Vertebrates
    Richard Fay; Fiscal Year: 2008
    ..abstract_text> ..
  29. SYMPOSIA FOR ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
    Elizabeth Keithley; Fiscal Year: 2008
    ..abstract_text> ..
  30. SPINAL MOTOR CONDUCTION AND RECOVERY AFTER HUMAN SCI
    Blair Calancie; Fiscal Year: 2009
    ..A slow-release formulation the K-channel blocker 4-aminopyridine will be tested for its effects on conduction in some cases. ..
  31. Control of Repetitive Movement in Parkinson's Disease
    Colum MacKinnon; Fiscal Year: 2009
    ..This project is relevant to public health because the findings will provide a better understanding of the human basal ganglia and its role in the production of disordered movement and help to develop improved treatments. ..
  32. Mechanisms of Deep Brain Stimulation: Joule Heating and Electroporation
    Marom Bikson; Fiscal Year: 2008
    ..These results will improve the success and safety of DBS. [unreadable] [unreadable] [unreadable]..
  33. Cancer Prevention Mastery-Model Internet Intervention
    Richard Winett; Fiscal Year: 2008
    ....
  34. In-Car Technology to Alert Attention-Imparied Drivers
    Matthew Rizzo; Fiscal Year: 2009
    ..The results may be used to design safer automobiles that use new strategies and technologies for collision warning, perceptual augmentation, and attention management. ..
  35. Vascular Alterations in the Prediabetic Condition
    Cynthia Cheng; Fiscal Year: 2008
    ....
  36. CUTANEOUS PATTERN PERCEPTION
    James Craig; Fiscal Year: 2007
    ..The results will also be relevant to the effects that intermediate surfaces such as surgical gloves have on tactile sensitivity and to the measurement and understanding of neurological problems. ..
  37. MODERATE ALCOHOL USE--CARDIOVASCULAR RISKS AND BENEFITS
    Thomas Giles; Fiscal Year: 2001
    ..The exacerbation or prevention of EIH will be related to drug effects on the cell-signaling pathway. This research can define the cell-signaling pathway in EIH and provide new and novel approaches to treating EIH. ..
  38. P20-Mediated Suppression of Vascular Force
    Christopher Rembold; Fiscal Year: 2004
    ..Many current treatments target smooth muscle to reduce tone. It is possible that targeting the force suppression pathway (i.e. p20) might provide comparable benefits. ..
  39. BODY WEIGHT SUPPORTED AMBULATION TRAINING AFTER SCI
    Blair Calancie; Fiscal Year: 2004
    ..abstract_text> ..
  40. Understanding the Nature of Visual Representation in Hum
    Zili Liu; Fiscal Year: 2003
    ..DESCRIPTION: (Applicant's Abstract) No abstract was provided by the applicant. ..
  41. FEATURES OF STIMULATION IMPORTANT FOR ELECTRICAL HEARING
    BRYAN PFINGST; Fiscal Year: 2003
    ..abstract_text> ..
  42. INNER EAR IMMUNE RESPONSES
    Elizabeth Keithley; Fiscal Year: 2002
    ..Such knowledge will enable clinicians to improve the treatments administered to patients who experience the unfortunate and potentially devastating trauma of rapidly progressing sensorineural hearing loss. ..
  43. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  44. Investigation of numerical abilities in infants with ERP
    ELIZABETH BRANNON; Fiscal Year: 2003
    ..Such insights will contribute to a fuller understanding of the development of mathematical thinking in adults, and may also have important implications for teaching elementary mathematics to children. ..
  45. CAUSES OF SLEEP-INDUCED BREATHING INSTABILITIES
    Jerome Dempsey; Fiscal Year: 2002
    ..These latter studies conduced in sleep are important to testing the sensitivity of respiratory control mechanisms to mechanical feedback-a problem which remains relatively unexplored, especially in the human. ..
  46. SEXUAL DIMORPHISM IN SEIZURE CONTROL
    JANA VELISKOVA; Fiscal Year: 2002
    ..Rats of both sexes and various ages will be used. These studies may lead to the development of new antiepileptic treatments that take into the account sexual age-related differences. ..
  47. NEUROTROPHIN CONTROL OF REM SLEEP
    Jack Yamuy; Fiscal Year: 2004
    ..This concerted set of experiments will be critical in elucidating the role that neurotrophins play in the control of REM sleep. ..
  48. Vision and Locomotion in Infants
    David Anderson; Fiscal Year: 2006
    ..Yet, such a test would permit the identification of babies who have mild or moderate visual or motor impairments so that interventions could be started at ages much earlier than at present. [unreadable] [unreadable]..
  49. BONY EFFECTS OF TRANSIENT NONSKELETAL ILLNESS
    Robert Heaney; Fiscal Year: 2001
    ....
  50. MECHANISMS OF SKELETAL MUSCLE FATIGUE
    Jay Williams; Fiscal Year: 2001
    ..In addition, it will attempt to identify direct links between muscle glycogen levels, CHO metabolism and the fatigue process. ..
  51. Information Transfer at Auditory Nerve Synapses
    MATTHEW XU FRIEDMAN; Fiscal Year: 2005
    ..This work will also provide information for implants that stimulate the brain directly, for patients who lack a functioning auditory nerve. ..
  52. Validation of rat models for resistant epilepsy therapy
    Wolfgang Loscher; Fiscal Year: 2005
    ..Our goal is to establish standard assays that can be employed by researchers to continue the search for treatments of drug resistant epilepsy. ..
  53. FUNCTIONAL EFFECTS OF DEAFNESS AND NEURAL STIMULATION
    BRYAN PFINGST; Fiscal Year: 2005
    ....
  54. OPTIMIZATION OF ELECTROCONVULSIVE THERAPY
    WILLIAM MCCALL; Fiscal Year: 2005
    ....
  55. Prenatal Corticosteroid Impact on Hippocampus
    LIBOR VELISEK; Fiscal Year: 2004
    ..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..
  56. Representation of number in infancy
    Elizabeth M Brannon; Fiscal Year: 2010
    ....
  57. Neurobiologic Study of Psychological Distress & Dementia
    Robert S Wilson; Fiscal Year: 2010
    ....
  58. NEURONAL ORGANIZATION OF BASAL GANGLIA
    Charles Wilson; Fiscal Year: 2003
    ..This latter will allow us to determine whether there is an actual mismatch between physiological and anatomical estimates of connectivity (i.e. non-functional synaptic connections). ..
  59. TRAINING IN APPLIED AND BASIC COGNITION
    CAREN ROTELLO; Fiscal Year: 2008
    ..Postdoctoral trainees are selected who can best benefit from the interdisciplinary collaborative research experiences offered by the program. ..
  60. Changes in cortical neurons and networks in mice overexpressing A beta
    Jack Waters; Fiscal Year: 2008
    ..These studies will provide critical insight into the cellular changes that occur in Alzheimer's disease and the resulting degeneration of neural networks. [unreadable] [unreadable] [unreadable]..
  61. CENTRAL NEURONAL MECHANISMS--DECOMPENSATED HEMORRHAGE
    PATRICE GUYENET; Fiscal Year: 2003
    ..Understanding the neurophysiological mechanisms triggered by hypotensive hemorrhage should lead to improved ability to manage this all too frequent clinical problem. ..
  62. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    PATRICE GUYENET; Fiscal Year: 2008
    ..The research will contribute to the basic physiological knowledge needed to understand how syrr pathetic tone is regulated in health and in diseases such as arrhythmias, hypertension and dysautonomias. ..
  63. Aging Effects on a-Adrenergic Activity in Female Bladder
    Natalia Dmitrieva; Fiscal Year: 2006
    ..The results of these studies will be the basis for developing a longer research program. ..
  64. Regulation of Progenenitor Cell Maturation in the Cortex
    Laura Lillien; Fiscal Year: 2007
    ..The targets of Akt- 1 that mediate maturation and/or self-renewal will be addressed in aim 3. ..
  65. White Matter Change and CNS Process in the Elderly
    Lisa Silbert; Fiscal Year: 2008
    ..This application proposes a structured didactic mentorship program for the principal investigator, Dr. Lisa Silbert, to ensure her independence as a clinical investigator at the end of the 5-year award period. [unreadable] [unreadable]..
  66. Auditory Neuroscience Training at Univ. Connecticut
    Shigeyuki Kuwada; Fiscal Year: 2006
    ..A postdoctoral trainee in this milieu cannot help but flourish to become a productive and creative investigator in his own right. ..