Summary: Intellectual or mental process whereby an organism becomes aware of or obtains knowledge.

Top Publications

  1. ncbi Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework
    S Dehaene
    Unité INSERM 334, Service Hospitalier Frederic Joliot, CEA DRM DSV, 4, place du General Leclerc, 91401 Cedex, Orsay, France
    Cognition 79:1-37. 2001
  2. ncbi Anterior cingulate conflict monitoring and adjustments in control
    John G Kerns
    Department of Psychological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Science 303:1023-6. 2004
  3. ncbi A default mode of brain function: a brief history of an evolving idea
    Marcus E Raichle
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 37:1083-90; discussion 1097-9. 2007
  4. pmc Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 100:253-8. 2003
  5. ncbi Conflict monitoring and cognitive control
    M M Botvinick
    Department of Psychology, Carnegie Mellon University, Pennsylvania, USA
    Psychol Rev 108:624-52. 2001
  6. ncbi An integrative theory of prefrontal cortex function
    E K Miller
    Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Neurosci 24:167-202. 2001
  7. ncbi Alzheimer's disease is a synaptic failure
    Dennis J Selkoe
    Center for Neurologic Diseases, Brigham and Women s Hospital, and the Harvard Center for Neurodegeneration and Repair, Boston, MA 02115, USA
    Science 298:789-91. 2002
  8. ncbi The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis
    A Miyake
    Department of Psychology, University of Colorado at Boulder, 80309-0345, USA
    Cogn Psychol 41:49-100. 2000
  9. ncbi The brainweb: phase synchronization and large-scale integration
    F Varela
    Laboratoire de Neurosciences Cognitives et Imagerie Cerebrale, Hopital de la Salpetriere, Paris 47 Boulevard de l Hôpital, 75651 Paris Cedex 13, France
    Nat Rev Neurosci 2:229-39. 2001
  10. pmc Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies
    Jeffrey R Binder
    Language Imaging Laboratory, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cereb Cortex 19:2767-96. 2009

Detail Information

Publications345 found, 100 shown here

  1. ncbi Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework
    S Dehaene
    Unité INSERM 334, Service Hospitalier Frederic Joliot, CEA DRM DSV, 4, place du General Leclerc, 91401 Cedex, Orsay, France
    Cognition 79:1-37. 2001
    ..Neurophysiological, anatomical, and brain-imaging data strongly argue for a major role of prefrontal cortex, anterior cingulate, and the areas that connect to them, in creating the postulated brain-scale workspace...
  2. ncbi Anterior cingulate conflict monitoring and adjustments in control
    John G Kerns
    Department of Psychological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Science 303:1023-6. 2004
  3. ncbi A default mode of brain function: a brief history of an evolving idea
    Marcus E Raichle
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 37:1083-90; discussion 1097-9. 2007
    ..Most critically, this work has called attention to the importance of intrinsic functional activity in assessing brain behavior relationships...
  4. pmc Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 100:253-8. 2003
    ..Our findings also provide insight into how this network is modulated by task demands and what functions it might subserve...
  5. ncbi Conflict monitoring and cognitive control
    M M Botvinick
    Department of Psychology, Carnegie Mellon University, Pennsylvania, USA
    Psychol Rev 108:624-52. 2001
    ..The second study implements a feedback loop connecting conflict monitoring to cognitive control, using this to simulate a number of important behavioral phenomena...
  6. ncbi An integrative theory of prefrontal cortex function
    E K Miller
    Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Neurosci 24:167-202. 2001
    ..We review neurophysiological, neurobiological, neuroimaging, and computational studies that support this theory and discuss its implications as well as further issues to be addressed..
  7. ncbi Alzheimer's disease is a synaptic failure
    Dennis J Selkoe
    Center for Neurologic Diseases, Brigham and Women s Hospital, and the Harvard Center for Neurodegeneration and Repair, Boston, MA 02115, USA
    Science 298:789-91. 2002
  8. ncbi The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis
    A Miyake
    Department of Psychology, University of Colorado at Boulder, 80309-0345, USA
    Cogn Psychol 41:49-100. 2000
    ..These results suggest that it is important to recognize both the unity and diversity of executive functions and that latent variable analysis is a useful approach to studying the organization and roles of executive functions...
  9. ncbi The brainweb: phase synchronization and large-scale integration
    F Varela
    Laboratoire de Neurosciences Cognitives et Imagerie Cerebrale, Hopital de la Salpetriere, Paris 47 Boulevard de l Hôpital, 75651 Paris Cedex 13, France
    Nat Rev Neurosci 2:229-39. 2001
    ..anatomical and functional organization of brain activity to enable the emergence of coherent behaviour and cognition. Although the mechanisms involved in large-scale integration are still largely unknown, we argue that the most ..
  10. pmc Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies
    Jeffrey R Binder
    Language Imaging Laboratory, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cereb Cortex 19:2767-96. 2009
  11. ncbi The role of the medial frontal cortex in cognitive control
    K Richard Ridderinkhof
    Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, Netherlands
    Science 306:443-7. 2004
  12. ncbi Effects of stress throughout the lifespan on the brain, behaviour and cognition
    Sonia J Lupien
    Universite de Montreal, Mental Health Research Centre, Fernand Seguin Hôpital Louis H Lafontaine, Quebec, Canada
    Nat Rev Neurosci 10:434-45. 2009
    ..period, infancy, childhood, adolescence, adulthood or aging, has an impact on brain structures involved in cognition and mental health...
  13. ncbi Conflict monitoring and anterior cingulate cortex: an update
    Matthew M Botvinick
    University of Pennsylvania, Center for Cognitive Neuroscience, 3720 Walnut Street, Philadelphia, PA 10104 6241, USA
    Trends Cogn Sci 8:539-46. 2004
    ..Recent research has also begun to shed light on the larger function of the ACC, suggesting some new possibilities concerning how conflict monitoring might fit into the cingulate's overall role in cognition and action.
  14. ncbi Fitness effects on the cognitive function of older adults: a meta-analytic study
    Stanley Colcombe
    Beckman Institute and Department of Psychology, University of Illinois, Urbana, 61801, USA
    Psychol Sci 14:125-30. 2003
    ..Most important fitness training was found to have robust but selective benefits for cognition, with the largest fitness-induced benefits occurring for executive-control processes...
  15. ncbi A mechanism for cognitive dynamics: neuronal communication through neuronal coherence
    Pascal Fries
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    Trends Cogn Sci 9:474-80. 2005
    ..Thus, a flexible pattern of coherence defines a flexible communication structure, which subserves our cognitive flexibility...
  16. pmc Neurophysiological and computational principles of cortical rhythms in cognition
    Xiao Jing Wang
    Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Physiol Rev 90:1195-268. 2010
    ..This review focuses on oscillations in the cerebral cortex that occur during cognition, in alert behaving conditions...
  17. ncbi Grounded cognition
    Lawrence W Barsalou
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    Annu Rev Psychol 59:617-45. 2008
    Grounded cognition rejects traditional views that cognition is computation on amodal symbols in a modular system, independent of the brain's modal systems for perception, action, and introspection...
  18. pmc A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks
    Devarajan Sridharan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:12569-74. 2008
    ..Our findings have important implications for a unified view of network mechanisms underlying both exogenous and endogenous cognitive control...
  19. pmc Wandering minds: the default network and stimulus-independent thought
    Malia F Mason
    Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA
    Science 315:393-5. 2007
    ..of human minds to wander, little is known about the neural operations that support this core component of human cognition. Using both thought sampling and brain imaging, the current investigation demonstrated that mind-wandering is ..
  20. ncbi Can social interaction constitute social cognition?
    Hanne De Jaegher
    Marie Curie Project DISCOS, Department of Psychiatry, University of Heidelberg, Vossstrasse 4, D 69115 Heidelberg, Germany
    Trends Cogn Sci 14:441-7. 2010
    An important shift is taking place in social cognition research, away from a focus on the individual mind and toward embodied and participatory aspects of social understanding...
  21. ncbi For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion
    Kevin N Ochsner
    Department of Psychology, Columbia University, 369 Schermerhorn Hall, New York, NY 10027, USA
    Neuroimage 23:483-99. 2004
  22. pmc Influence of cognitive control and mismatch on the N2 component of the ERP: a review
    Jonathan R Folstein
    Department of Psychology, University of Arizona, Tucson, Arizona, USA
    Psychophysiology 45:152-70. 2008
    ..We focus on the visual modality for which components with frontocentral and more posterior scalp distributions can be readily distinguished...
  23. pmc Cognitive reserve
    Yaakov Stern
    Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, United States
    Neuropsychologia 47:2015-28. 2009
    ..It then focuses on methodologic issues that are important when attempting to elucidate the neural underpinnings of cognitive reserve using imaging studies, and reviews some of our group's work in order to demonstrate these issues...
  24. ncbi Be smart, exercise your heart: exercise effects on brain and cognition
    Charles H Hillman
    Charles H Hillman is at the Department of Kinesiology and Community Health, 213 Louise Freer Hall, 906 South Goodwin Avenue, University of Illinois, Urbana, Illinois 61801, USA
    Nat Rev Neurosci 9:58-65. 2008
    ..Human and non-human animal studies have shown that aerobic exercise can improve a number of aspects of cognition and performance...
  25. ncbi Large-scale brain networks in cognition: emerging methods and principles
    Steven L Bressler
    Center for Complex Systems and Brain Sciences, Department of Psychology, Florida Atlantic University, Boca Raton, FL, USA
    Trends Cogn Sci 14:277-90. 2010
    An understanding of how the human brain produces cognition ultimately depends on knowledge of large-scale brain organization...
  26. pmc Evidence for a frontoparietal control system revealed by intrinsic functional connectivity
    Justin L Vincent
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neurophysiol 100:3328-42. 2008
    ..The frontoparietal control system is therefore anatomically positioned to integrate information from these two opposing brain systems...
  27. ncbi The principal features and mechanisms of dopamine modulation in the prefrontal cortex
    Jeremy K Seamans
    Department of Physiology, MUSC, 173 Ashley Avenue, Suite 403, Charleston, SC 29425, USA
    Prog Neurobiol 74:1-58. 2004
    ..Based on these factors, a theory is proposed for DA's action in PFC. This theory suggests that DA acts to expand or contract the breadth of information held in working memory buffers in PFC networks...
  28. ncbi Uncertainty-based competition between prefrontal and dorsolateral striatal systems for behavioral control
    Nathaniel D Daw
    Gatsby Computational Neuroscience Unit, University College London, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
    Nat Neurosci 8:1704-11. 2005
    ..This provides a unifying account of a wealth of experimental evidence about the factors favoring dominance by either system...
  29. ncbi The free-energy principle: a unified brain theory?
    Karl Friston
    The Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London, WC1N 3BG, UK
    Nat Rev Neurosci 11:127-38. 2010
    ..This is the quantity that is optimized under the free-energy principle, which suggests that several global brain theories might be unified within a free-energy framework...
  30. ncbi Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies
    Catherine J Stoodley
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuroimage 44:489-501. 2009
    ..Prospective studies of multiple domains within single individuals are necessary to better elucidate neurobehavioral structure-function correlations in the cerebellar posterior lobe...
  31. ncbi Neuroimaging studies of working memory: a meta-analysis
    Tor D Wager
    University of Michigan, Ann Arbor, Michigan, USA
    Cogn Affect Behav Neurosci 3:255-74. 2003
    ..Finally, we consider a potential fourth executive function: selective attention to features of a stimulus to be stored in WM, which leads to increased probability of activating the medial prefrontal cortex (BA 32) in storage tasks...
  32. ncbi The structural basis of inter-individual differences in human behaviour and cognition
    Ryota Kanai
    The UCL Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
    Nat Rev Neurosci 12:231-42. 2011
    ..We propose that inter-individual differences can be used as a source of information to link human behaviour and cognition to brain anatomy.
  33. ncbi The neural basis of economic decision-making in the Ultimatum Game
    Alan G Sanfey
    Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
    Science 300:1755-8. 2003
    ..Unfair offers elicited activity in brain areas related to both emotion (anterior insula) and cognition (dorsolateral prefrontal cortex)...
  34. ncbi Joint action: bodies and minds moving together
    Natalie Sebanz
    Rutgers, The State University of New Jersey, Psychology Department, Smith Hall, 101 Warren Street, Newark, NJ 07102, USA
    Trends Cogn Sci 10:70-6. 2006
    ..Several mechanisms are proposed that allow individuals to share representations, to predict actions, and to integrate predicted effects of own and others' actions...
  35. ncbi A unifying view of the basis of social cognition
    Vittorio Gallese
    Department of Neuroscience, Section of Physiology, University of Parma, Italy
    Trends Cogn Sci 8:396-403. 2004
    ..A similar mechanism, but involving the activation of viscero-motor centers, underlies the experiential understanding of the emotions of others...
  36. pmc Relating introspective accuracy to individual differences in brain structure
    Stephen M Fleming
    Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N 3BG, UK
    Science 329:1541-3. 2010
    ..Our findings point to a focal neuroanatomical substrate for introspective ability, a substrate distinct from that supporting primary perception...
  37. pmc Gaze cueing of attention: visual attention, social cognition, and individual differences
    Alexandra Frischen
    Macquarie Centre for Cognitive Science, Macquarie University, Sydney, NSW, Australia
    Psychol Bull 133:694-724. 2007
    ..The contribution of this paradigm has been significant and will likely continue to advance knowledge across diverse fields within psychology and neuroscience...
  38. pmc Selective review of cognitive aging
    Timothy A Salthouse
    Department of Psychology, University of Virginia, Charlottesville, Virginia 22904 4400, USA
    J Int Neuropsychol Soc 16:754-60. 2010
    ..of cognitive functioning, and what methods can be used to identify causes of age-related influences on cognition. Although definitive answers are not yet possible, quite a bit of information relevant to the questions is now ..
  39. ncbi Anterior cingulate cortex, error detection, and the online monitoring of performance
    C S Carter
    Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Science 280:747-9. 1998
    ..This suggests that the ACC detects conditions under which errors are likely to occur rather than errors themselves...
  40. ncbi Brain aging, cognition in youth and old age and vascular disease in the Lothian Birth Cohort 1936: rationale, design and methodology of the imaging protocol
    Joanna M Wardlaw
    Brain Research Imaging Centre, Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Int J Stroke 6:547-59. 2011
    ..However, the changes in brain structure that accompany normal aging, and the role they play in cognitive decline, remain to be fully elucidated...
  41. pmc Cardiovascular fitness, cortical plasticity, and aging
    Stanley J Colcombe
    The Beckman Institute, and Neuroscience Program, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 101:3316-21. 2004
    ..These data suggest that increased cardiovascular fitness can affect improvements in the plasticity of the aging human brain, and may serve to reduce both biological and cognitive senescence in humans...
  42. ncbi The processing-speed theory of adult age differences in cognition
    T A Salthouse
    Georgia Institute of Technology, Atlanta 30332 0170, USA
    Psychol Rev 103:403-28. 1996
    A theory is proposed to account for some of the age-related differences reported in measures of Type A or fluid cognition. The central hypothesis in the theory is that increased age in adulthood is associated with a decrease in the speed ..
  43. ncbi Six views of embodied cognition
    Margaret Wilson
    Department of Psychology, University of California, Santa Cruz, CA 95064, USA
    Psychon Bull Rev 9:625-36. 2002
    The emerging viewpoint of embodied cognition holds that cognitive processes are deeply rooted in the body's interactions with the world...
  44. ncbi Brain systems mediating cognitive interference by emotional distraction
    Florin Dolcos
    Brain Imaging and Analysis Center, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 26:2072-9. 2006
  45. pmc A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study
    Glenn E Smith
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Geriatr Soc 57:594-603. 2009
    ..To investigate the efficacy of a novel brain plasticity-based computerized cognitive training program in older adults and to evaluate the effect on untrained measures of memory and attention and participant-reported outcomes...
  46. ncbi Changes in cortical dopamine D1 receptor binding associated with cognitive training
    Fiona McNab
    Neuropediatric Unit, Department of Woman and Child Health, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
    Science 323:800-2. 2009
    Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission...
  47. pmc Putting brain training to the test
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK
    Nature 465:775-8. 2010
    ..Although improvements were observed in every one of the cognitive tasks that were trained, no evidence was found for transfer effects to untrained tasks, even when those tasks were cognitively closely related...
  48. ncbi Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection
    Martin Sarter
    Department of Psychology, University of Michigan, 525 E University Ave, Ann Arbor, MI 48109 1109, USA
    Brain Res Brain Res Rev 48:98-111. 2005
  49. pmc The role of default network deactivation in cognition and disease
    Alan Anticevic
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Trends Cogn Sci 16:584-92. 2012
    ..Collectively, this research highlights the functional relevance of DMN suppression for goal-directed cognition, possibly by reducing goal-irrelevant functions supported by the DMN (e.g...
  50. ncbi Social cognition and the brain: a meta-analysis
    Frank Van Overwalle
    Department of Psychology, Vrije Universiteit Brussel, Brussel, Belgium
    Hum Brain Mapp 30:829-58. 2009
    This meta-analysis explores the location and function of brain areas involved in social cognition, or the capacity to understand people's behavioral intentions, social beliefs, and personality traits...
  51. ncbi Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial
    Nicola T Lautenschlager
    WA Centre for Health and Ageing, University of Western Australia, Melbourne, Australia
    JAMA 300:1027-37. 2008
    ..Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking...
  52. ncbi Individual differences in non-verbal number acuity correlate with maths achievement
    Justin Halberda
    Johns Hopkins University, Ames Hall, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    Nature 455:665-8. 2008
    ..Further research will determine whether early differences in number sense acuity affect later maths learning, whether maths education enhances number sense acuity, and the extent to which tertiary factors can affect both...
  53. ncbi Guidelines for using human event-related potentials to study cognition: recording standards and publication criteria
    T W Picton
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Psychophysiology 37:127-52. 2000
    ..The data must then be analyzed and presented in a way that allows different studies to be compared readily. This paper presents guidelines for recording ERPs and criteria for publishing the results...
  54. ncbi From sensation to cognition
    M M Mesulam
    Department of Neurology, Northwestern University Medical School, Chicago 60611, USA
    Brain 121:1013-52. 1998
    ..extensive associative elaboration and attentional modulation as it becomes incorporated into the texture of cognition. This process occurs along a core synaptic hierarchy which includes the primary sensory, upstream unimodal, ..
  55. pmc Effects of cognitive training interventions with older adults: a randomized controlled trial
    Karlene Ball
    Department of Psychology, University of Alabama at Birmingham, 35294 2100, USA
    JAMA 288:2271-81. 2002
    ..However, few studies have addressed whether improving cognitive functions might have short- or long-term effects on activities related to living independently...
  56. ncbi Brain white matter tract integrity as a neural foundation for general intelligence
    L Penke
    Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 17:1026-30. 2012
  57. ncbi Enhanced perceptual functioning in autism: an update, and eight principles of autistic perception
    Laurent Mottron
    Pervasive Developmental Disorders Specialized Clinic, Riviere des Prairies Hospital, and Fernand Seguin Research Center, University of Montreal, Canada
    J Autism Dev Disord 36:27-43. 2006
    ..The overfunctioning of brain regions typically involved in primary perceptual functions may explain the autistic perceptual endophenotype...
  58. pmc Frames, biases, and rational decision-making in the human brain
    Benedetto De Martino
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1 3AR, UK
    Science 313:684-7. 2006
    ..This finding highlights the importance of incorporating emotional processes within models of human choice and suggests how the brain may modulate the effect of these biasing influences to approximate rationality...
  59. ncbi Valid conjunction inference with the minimum statistic
    Thomas Nichols
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Neuroimage 25:653-60. 2005
    ..This result holds even if the comparisons are not independent. We suggest that the revised test proposed here is the appropriate means for conjunction inference in neuroimaging...
  60. ncbi A critical look at the embodied cognition hypothesis and a new proposal for grounding conceptual content
    Bradford Z Mahon
    Cognitive Neuropsychology Laboratory, Harvard University, Cambridge, MA 02138, USA
    J Physiol Paris 102:59-70. 2008
    ..Such results have been interpreted as indicating that concepts, and important aspects of cognition more broadly, are embodied. That conclusion does not follow from the empirical evidence...
  61. pmc Disruption of large-scale brain systems in advanced aging
    Jessica R Andrews-Hanna
    Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Neuron 56:924-35. 2007
    ..accompanied by disruptive alterations in the coordination of large-scale brain systems that support high-level cognition. In 93 adults aged 18 to 93, we demonstrate that aging is characterized by marked reductions in normally present ..
  62. pmc The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    BMC Geriatr 7:28. 2007
    ..A limitation of many studies is the lack of a sufficiently long period between cognitive assessments to examine determinants. Here, the aim is to examine influences on cognitive ageing between childhood and old age...
  63. ncbi Structural and functional brain development and its relation to cognitive development
    B J Casey
    Department of Psychiatry, The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, 525 East 68th Street, Box 171, New York, NY 10021, USA
    Biol Psychol 54:241-57. 2000
    ..It is clear that innovative methods like fMRI together with MRI-based morphometry and nonhuman primate studies will transform our current understanding of human brain development and its relation to behavioral development...
  64. pmc Gait and cognition: a complementary approach to understanding brain function and the risk of falling
    Manuel Montero-Odasso
    Division of Geriatric Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada
    J Am Geriatr Soc 60:2127-36. 2012
    ..but increasing evidence from clinical practice, epidemiological studies, and clinical trials shows that gait and cognition are interrelated in older adults...
  65. ncbi Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, 97239, USA
    Radiat Res 162:39-47. 2004
    ..The significant loss of proliferating SGZ cells and their progeny suggests a contributory role of reduced neurogenesis in the pathogenesis of radiation-induced cognitive impairments...
  66. ncbi Storage and executive processes in the frontal lobes
    E E Smith
    Department of Psychology, Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Science 283:1657-61. 1999
    ..Two of the fundamental executive processes are selective attention and task management. Both processes activate the anterior cingulate and dorsolateral prefrontal cortex...
  67. pmc Prenatal undernutrition and cognitive function in late adulthood
    Susanne R de Rooij
    Department of Clinical Epidemiology Biostatistics and Bioinformatics, Academic Medical Center of the University of Amsterdam, 1100 DD, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 107:16881-6. 2010
    ..We hypothesize that this decline may be an early manifestation of an accelerated cognitive aging process...
  68. ncbi Can cognitive processes be inferred from neuroimaging data?
    Russell A Poldrack
    Department of Psychology and Brain Research Institute, UCLA, Los Angeles, CA 90095 1563, USA
    Trends Cogn Sci 10:59-63. 2006
    There is much interest currently in using functional neuroimaging techniques to understand better the nature of cognition. One particular practice that has become common is 'reverse inference', by which the engagement of a particular ..
  69. ncbi The human inferior parietal cortex: cytoarchitectonic parcellation and interindividual variability
    Svenja Caspers
    C and O Vogt Brain Research Institute, University of Dusseldorf, P O Box 10 10 07, 40001 Dusseldorf, Germany
    Neuroimage 33:430-48. 2006
    ..Furthermore, the map is registered in three dimensions and thereby provides a robust anatomical base for interpreting functional imaging studies...
  70. ncbi Does working memory training work? The promise and challenges of enhancing cognition by training working memory
    Alexandra B Morrison
    Department of Psychology, Temple University, 6th Floor Weiss Hall, Philadelphia, PA 19122, USA
    Psychon Bull Rev 18:46-60. 2011
    ..Given the established relationship between WM and higher cognition, these successful training studies have led to speculation that WM training may yield broad cognitive benefits...
  71. pmc Modes and models of forebrain cholinergic neuromodulation of cognition
    Michael E Hasselmo
    Center for Memory and Brain, Department of Psychology, Boston University, Boston, MA 02215, USA
    Neuropsychopharmacology 36:52-73. 2011
    ..The available evidence and these models point to new principles governing the development of the next generation of cholinergic treatments for cognitive disorders...
  72. ncbi Uniquely human social cognition
    Rebecca Saxe
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology 46 4019, 43 Vassar St, Cambridge MA, 02138, USA
    Curr Opin Neurobiol 16:235-9. 2006
    Recent data identify distinct components of social cognition associated with five brain regions. In posterior temporal cortex, the extrastriate body area is associated with perceiving the form of other human bodies...
  73. ncbi Understanding and sharing intentions: the origins of cultural cognition
    Michael Tomasello
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Behav Brain Sci 28:675-91; discussion 691-735. 2005
    We propose that the crucial difference between human cognition and that of other species is the ability to participate with others in collaborative activities with shared goals and intentions: shared intentionality...
  74. ncbi Intellectual ability and cortical development in children and adolescents
    P Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20182, USA
    Nature 440:676-9. 2006
    ..This study indicates that the neuroanatomical expression of intelligence in children is dynamic...
  75. ncbi Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry
    Marcel Adam Just
    Center for Cognitive Brain Imaging, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Cereb Cortex 17:951-61. 2007
    ..These findings suggest that the neural basis of altered cognition in autism entails a lower degree of integration of information across certain cortical areas resulting from ..
  76. ncbi An application of prefrontal cortex function theory to cognitive aging
    R L West
    Department of Psychology, University of South Carolina, USA
    Psychol Bull 120:272-92. 1996
    ..I found the frontal lobe hypothesis to perform well, with the exception of an inability to account for age-related declines in item recall and recognition memory, possibly a result of age-related declines in medial temporal function...
  77. pmc High gamma power is phase-locked to theta oscillations in human neocortex
    R T Canolty
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Science 313:1626-8. 2006
    ..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...
  78. ncbi The electronic-cigarette: effects on desire to smoke, withdrawal symptoms and cognition
    Lynne Dawkins
    School of Psychology, University of East London, Water Lane, Stratford, London, England, United Kingdom
    Addict Behav 37:970-3. 2012
    ..Few studies have evaluated acute effects on craving and mood, and none have explored effects on cognition. This study aimed to explore the effects of the White Super e-cigarette on desire to smoke, nicotine withdrawal ..
  79. ncbi Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review
    Erik G Willcutt
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    Biol Psychiatry 57:1336-46. 2005
    ..Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD...
  80. pmc Diffusion tensor imaging of cerebral white matter integrity in cognitive aging
    David J Madden
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA
    Biochim Biophys Acta 1822:386-400. 2012
    ..tensor imaging (DTI) of white matter (WM) integrity and the implications for age-related differences in cognition. Neurobiological mechanisms defined from DTI analyses suggest that a primary dimension of age-related decline in ..
  81. pmc Decoding the visual and subjective contents of the human brain
    Yukiyasu Kamitani
    ATR Computational Neuroscience Laboratories, 2 2 2 Hikaridai, Keihanna Science City, Kyoto 619 0288, Japan
    Nat Neurosci 8:679-85. 2005
    ..Our approach provides a framework for the readout of fine-tuned representations in the human brain and their subjective contents...
  82. ncbi The cortico-basal ganglia integrative network: the role of the thalamus
    Suzanne N Haber
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA suzanne
    Brain Res Bull 78:69-74. 2009
    ..the frontal cortical-basal ganglia-thalamic circuits that mediate motivation and emotional drive, planning and cognition for the development and expression of goal-directed behaviors...
  83. ncbi Breakfast habits, nutritional status, body weight, and academic performance in children and adolescents
    Gail C Rampersaud
    Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, SW 23rd Drive, FETL Building 685, Gainesville, FL 32611 0720, USA
    J Am Diet Assoc 105:743-60; quiz 761-2. 2005
    ..We advocate consumption of a healthful breakfast on a daily basis consisting of a variety of foods, especially high-fiber and nutrient-rich whole grains, fruits, and dairy products...
  84. ncbi Perceptual symbol systems
    L W Barsalou
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Behav Brain Sci 22:577-609; discussion 610-60. 1999
    ..Implications for cognition, neuroscience, evolution, development, and artificial intelligence are explored.
  85. ncbi The neural basis of inhibition in cognitive control
    Adam R Aron
    Department of Psychology, University of California, San Diego, La Jolla, CA 92093, USA
    Neuroscientist 13:214-28. 2007
    ..This article examines the role that neuroscience can play when examining whether the psychological concept of active inhibition can be meaningfully applied in cognitive control research...
  86. ncbi A neuropsychological theory of positive affect and its influence on cognition
    F G Ashby
    Department of Psychology, University of California, Santa Barbara 93106, USA
    Psychol Rev 106:529-50. 1999
    ..For example, the theory assumes that creative problem solving is improved, in part, because increased dopamine release in the anterior cingulate improves cognitive flexibility and facilitates the selection of cognitive perspective...
  87. pmc Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study
    Henry W Mahncke
    Posit Science Corporation, 225 Bush Street, San Francisco, CA 94104, USA
    Proc Natl Acad Sci U S A 103:12523-8. 2006
    Normal aging is associated with progressive functional losses in perception, cognition, and memory...
  88. pmc Amyloid deposition is associated with impaired default network function in older persons without dementia
    Reisa A Sperling
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 63:178-88. 2009
  89. ncbi The role of the right temporoparietal junction in social interaction: how low-level computational processes contribute to meta-cognition
    Jean Decety
    Department of Psychology, and Center for Cognitive and Social Neuroscience, The University of Chicago, Chicago, IL 60637, USA
    Neuroscientist 13:580-93. 2007
    ..cortex, at the junction with the posterior temporal cortex, plays a critical role in various aspects of social cognition such as theory of mind and empathy...
  90. ncbi Dual-processing accounts of reasoning, judgment, and social cognition
    Jonathan St B T Evans
    Center for Thinking and Language, School of Psychology, University of Plymouth, Plymouth PL4 8AA, United Kingdom, USA
    Annu Rev Psychol 59:255-78. 2008
    This article reviews a diverse set of proposals for dual processing in higher cognition within largely disconnected literatures in cognitive and social psychology...
  91. ncbi Anterior prefrontal function and the limits of human decision-making
    Etienne Koechlin
    Institut National de la Sante et de la Recherche Medicale, Departement d Etudes Cognitives, Ecole Normale Superieure, Universite Pierre et Marie Curie, 9, quai Saint Bernard, 75005 Paris, France
    Science 318:594-8. 2007
  92. pmc Long-term effects of cognitive training on everyday functional outcomes in older adults
    Sherry L Willis
    Department of Human Development and Family Studies, Pennsylvania State University, State College, PA 16801
    JAMA 296:2805-14. 2006
    ..Cognitive training has been shown to improve cognitive abilities in older adults but the effects of cognitive training on everyday function have not been demonstrated...
  93. ncbi An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance
    Gary Aston-Jones
    Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Annu Rev Neurosci 28:403-50. 2005
    ..We propose that these frontal areas produce the above patterns of LC activity to optimize utility on both short and long timescales...
  94. ncbi Neurocognitive mechanisms of cognitive control: the role of prefrontal cortex in action selection, response inhibition, performance monitoring, and reward-based learning
    K Richard Ridderinkhof
    Department of Psychology, University of Amsterdam, The Netherlands
    Brain Cogn 56:129-40. 2004
    ..Lateral and orbitofrontal divisions of prefrontal cortex are involved in subsequently implementing appropriate adjustments...
  95. ncbi The architecture of cognitive control in the human prefrontal cortex
    Etienne Koechlin
    Institut National de la Sante et de Recherche Medicale, Universite Pierre et Marie Curie, 9, quai St Bernard, 75005 Paris, France
    Science 302:1181-5. 2003
    ..The results support an unified modular model of cognitive control that describes the overall functional organization of the human lateral PFC and has basic methodological and theoretical implications...
  96. ncbi The locus coeruleus and noradrenergic modulation of cognition
    Susan J Sara
    CNRS UMR 7152, College de France, Paris 75005, France
    Nat Rev Neurosci 10:211-23. 2009
  97. ncbi Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
    Paul A Adlard
    Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
    Neuron 59:43-55. 2008
    ..The speed of recovery of the animals underscores the acutely reversible nature of the cognitive deficits associated with transgenic models of AD...
  98. pmc Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition
    R Nathan Spreng
    Department of Psychology, Harvard University, Cambridge MA 02138, USA
    Neuroimage 53:303-17. 2010
    ..Consequently, many assume that default network activity is suppressed during goal-directed cognition. We challenge this assumption in an fMRI study of planning...
  99. ncbi Genetic foundations of human intelligence
    Ian J Deary
    Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland, UK
    Hum Genet 126:215-32. 2009
    ..Here, we describe the human intelligence phenotype, summarise the evidence for its heritability, provide an overview of and comment on molecular genetic studies, and comment on future progress in the field...
  100. pmc Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion
    Christopher Barkus
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
    Eur J Pharmacol 626:49-56. 2010
    ..Wied had a fundamental interest in the brain and behaviour, with a particular interest in the interface between cognition and emotion, and how impairments at this interface could underlie human psychopathology...
  101. ncbi Value computations in ventral medial prefrontal cortex during charitable decision making incorporate input from regions involved in social cognition
    Todd A Hare
    Computation and Neural Systems and Humanities and Social Science Divisions, California Institute of Technology, Pasadena, California 91125 7700, USA
    J Neurosci 30:583-90. 2010
    ..functional connectivity analyses indicated that the value signal in VMPFC might integrate inputs from networks, including the anterior insula and posterior superior temporal cortex, that are thought to be involved in social cognition.

Research Grants77

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
    ..anti-AD strategy, vaccination with the A( peptide, also reduces A( deposition in AD transgenic mice and improves cognition. Two major hypotheses regarding the actions of A( immunotherapy are the facilitation of microglial phagocytosis ..
  3. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..synthesized de novo in the brain, have been implicated in functions ranging from stress, depression, anxiety, to cognition. One neurosteroid is progesterone, a classic sex hormone involved in the regulation of reproduction...
  4. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..particularly), are uniquely concentrated in the central nervous system and are involved in neuroprotection, cognition, and other brain and retinal functions...
  5. Regulation of AKAP79 Postsynaptic Membrane Targeting
    MARK L DELL'ACQUA; Fiscal Year: 2012
    ..and glutamate receptor function are believed to be relevant for mechanisms of altered synaptic plasticity and cognition in neurological disorders such as Alzheimer's and epilepsy and mental health disorders such as Down ..
  6. Adenosine and the Basal Forebrain in the Control of Behavioral State
    Robert E Strecker; Fiscal Year: 2012
    ..for as little as 2 h for several days can impair cardiovascular, immune, and endocrine functions, as well as cognition and daytime vigilance...
  7. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..formation of appropriate synapses is crucial for establishment of neuronal circuits that underlie behavior and cognition. Minor irregularities during synapse formation can lead to developmental disorders such as autism, mental ..
  8. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    ..This necessitates the development of new, better acting and safer medications for enhancing cognition. In this SBIR Phase I project, PhysioGenix will determine the efficacy, pharmacokinetics (PK), maximum tolerated ..
  9. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
    ..Perinatal iron deficiency negatively impacts intelligence and cognition in children. Heme is the most bioavailable form of iron for human consumption...
  10. Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity
    Vickram Ramkumar; Fiscal Year: 2013
    ..Loss of hearing at this developmental stage hampers speech, cognition and social development. Thus, there is an urgent need to develop effective treatments to ameliorate ototoxicity...
  11. Neuroimaging Assessments of Brain Integrity in Aging Mice
    Ai Ling Lin; Fiscal Year: 2013
    ..CMRO2, CBF, CMRGlc, total ATP concentration;and, thus preserved brain structure, functional connectivity, and cognition during aging...
  12. The Role of Astrocytes in Cortical Interneuron Development
    KAREN MULLER SMITH; Fiscal Year: 2013
    ..rhythms so that excitatory neurons can fire in synchrony- properties deemed to be critical for their function in cognition and behavioral control...
  13. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    ..These insights could lead to development of therapeutics that result in improved cognition in the postmenopausal woman by potentially preventing changes in ER2 gene expression...
  14. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2013
    ..IFN? can inhibit HIV/gp120 from inducing neuronal damage and impairing neurogenesis and compromising memory and cognition by a unique combination of mechanisms, comprising the induction of neuroprotective ?-chemokines and neurotrophic ..
  15. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..healthy postmenopausal women taking 17[unreadable]-estradiol (E2), the major female estrogen, 2) improvements in cognition in subjects treated with physiologically relevant sex steroids: women treated with E2 (3 controlled/1 ..
  16. A Computational Framework for Mapping Long Range Genetic Circuits
    Tolga Tasdizen; Fiscal Year: 2010
    ..The long range links to other cortical or subcortical structures involved in regulation of emotion or cognition, particularly at the scale needed for primate systems cannot yet be visualized...
  17. Vascular and Skeletal Muscle Function in Gulf War Veterans Illness
    Scott Kinlay; Fiscal Year: 2013
    ..criteria, which are based on statistical symptom cluster analysis resulting in three categories: fatigue, mood/ cognition, and musculoskeletal symptoms...
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    ..proteins that affect the intensity and duration of acetylcholine action, a critical neurotransmitter affecting cognition in the CNS and peripheral autonomic and motor function...
  19. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..This is of special importance here in regard to cognition/amnesia and other processes mediated by the hippocampus...
  20. Dietary Cholesterol and Defects in Cholesterol Synthesis
    ROBERT DAVID STEINER; Fiscal Year: 2013
    ..Treatment efficacy will be judged primarily on changes in cognition and behavior (clinical) but also on surrogate biochemical and other measures (i.e...
  21. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..the perimenopausal decline in estradiol, and thereby negatively impacts central physiological processes such as cognition, learning, and attention, and leads to perturbation of the circadian sleep-wake cycle...
  22. Intravenous Protein Therapy for Myotonic Dystrophy Type 1
    Richard Weisbart; Fiscal Year: 2010
    ..muscle wasting and myotonia, insulin resistance, testicular atrophy, cutaneous tumors cardiac arrhythmia and cognition defects (4- 8)...
  23. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    John E Rash; Fiscal Year: 2012
    ..neuronal oscillatory synchronizations that are thought to underlie consciousness, arousal from sleep, cognition, associative binding for learning and memory, and fine motor control, and which become pathologically altered in ..
  24. Mechanism of CREB dysregulation in Alzheimer brain
    Subbiah Pugazhenthi; Fiscal Year: 2013
    ..Cyclic AMP response element binding protein (CREB), a nuclear transcription factor, enhances cognition, memory formation and neuronal survival. CREB is known to be downregulated in the AD brain...
  25. Low level exposure to PBDEs: testing the hormetic and epigenetic hypotheses
    Lucio G Costa; Fiscal Year: 2013
    ..periods causes long-lasting behavioral abnormalities, particularly in the domains of motor activity and cognition. Limited evidence is also suggestive of possible developmental adverse effects in humans from PBDE exposure...
  26. Predictors of sleep-dependent Memory Consolidation in Obstructive Sleep Apnea
    Ina E Djonlagic; Fiscal Year: 2013 Associate Professor of Psychiatry at Harvard Medical School and Director of the Center for Sleep and Cognition at Beth Israel Deaconess Medical Center. Dr...
  27. Air Toxics, Neighborhood Environment and Risk of Oral Clefts
    Philip J Lupo; Fiscal Year: 2013
    ..Children with CL[unreadable]P suffer deficits in speech, hearing and cognition and have higher morbidity and mortality throughout life compared to their unaffected contemporaries...
  28. Neuroendocrine Contribution to Behavior &Cognition in the Female Lifespan
    C NEILL NEILL EPPERSON; Fiscal Year: 2013 which sex hormones and neurosteroids interact with neurotransmitters to modulate behavior, mood, and cognition in women...
  29. Pathogenesis of cognitive/neurologic deficits in central nervous system malaria
    Chandy C John; Fiscal Year: 2012
    ..However, the effects of CM on cognition in younger children have not been prospectively characterized, and the underlying question of what leads to ..
  30. Genomics of RNA Editing: Identification and Regulation
    Jin Billy Li; Fiscal Year: 2013
    ..suicide, glioma, and cancers, and may have contributed to the evolutionary development of human neurobiology and cognition. While numerous RNA editing sites have been identified to date, we are still far from possessing a complete list ..
  31. Epigenetics and choline: mediation of fetal alcohol effects in a rat model
    Carol L Cheatham; Fiscal Year: 2013
    ..provided by applicant): The proposed training is designed to provide the candidate with a background in animal cognition and testing as well as training in molecular mechanisms of development...
  32. Presynaptic Mechanisms Regulating the Dopamine Transporter
    JAMES A HARDAWAY; Fiscal Year: 2013
    ..In humans, DA signaling modulates arousal, cognition, reward, and motor function...
  33. Modeling schizophrenia gamma deficits using cell-specific RNAi knockdown of GAD67
    RITCHIE EDWARD BROWN; Fiscal Year: 2012
    ..construct validity which can be used to develop new therapeutic approaches to improve gamma oscillations and cognition;and (iii) Determine whether downregulation of GAD67 expression can cause cortical circuitry deficits typical of ..
  34. SIRT1 as a regulator of health and lifespan of mammals
    David A Sinclair; Fiscal Year: 2013
    ..of aging in highly energetic organs and tissues can be reversed by assessing metabolism, motor function, and cognition. Recent evidence from C...
  35. The Greatest Generation: The NAS-NRC WWII Twin Registry as a Scientific Resource
    Margaret Gatz; Fiscal Year: 2012
    ..Selected twins have also participated in sub-studies where data include screening for cognition and various complex diseases, in-person medical examinations and resulting diagnoses, and genotyping...
  36. Epigenetic Changes in the Glucocorticoid Receptor Gene Due to Arsenic Exposure
    Andrea M Allan; Fiscal Year: 2013
    ..The GRs are particularly concentrated in areas of central importance for cognition (hippocampus, amygdala and frontal cortex)...
  37. Frontal Lobe Injury and Executive Control of Cognition and Emotion
    Diane Swick; Fiscal Year: 2013
    ..Since these conditions can result in tremendous losses of productivity, the development of more sensitive assessments of brain health can assist in tailoring rehabilitation efforts to the needs of individual patients. ..
  38. Development and Regulation of Cholinergic Synapses
    Andres Villu Maricq; Fiscal Year: 2013
    ..Cholinergic neurotransmission is implicated in nicotine addiction, memory and cognition. Perturbations in a7 AChR regulation and function are thought to contribute to a broad spectrum of neuronal ..
  39. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2012
    ..a pivotal role in regulating multiple behaviors including mood, motivation/reward, motor activity, sleep and cognition. To explore effects of cytokines on DA and the basal ganglia, we have studied patients receiving treatment with ..
  40. Human VGF Polymorphisms and Depression
    Stephen R Salton; Fiscal Year: 2010
    ..mouse models, determining whether carriers of this polymorphism could be predisposed to depression and impaired cognition, much as those with aberrant BDNF expression and/or signaling are at risk for memory and behavioral disorders...
  41. Synaptic autoimmunity in disorders of memory, behavior, cognition and psychosis
    Josep Dalmau; Fiscal Year: 2010
    ..the characterization of autoimmune responses to synaptic proteins that result in disorders of behavior, memory, cognition and psychosis...
  42. Epidemiology of Retinopathy and other Complications in Long Term Type 1 Diabetes
    Michael Y Tsai; Fiscal Year: 2013
    ..acuity, carotid artery ultrasound, electrocardiogram, measurement of skin intrinsic fluorescence, tests of cognition, and measurement of serum (e.g...
  43. Freeze-Dried Blueberries: Prevention and Rehabilitation Strategies in MS
    Susan O McGuire; Fiscal Year: 2011
    ..Some also improve cognition and depression in animals, symptoms that are troublesome for the MS patient...
  44. Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs
    Heike Wulff; Fiscal Year: 2012
    ..validate KCa2 channels as novel pharmacological targets for the treatment of epilepsy and would further provide the scientific community with tool compounds to study the role of KCa2 channels in ataxia, neuropathic pain and cognition.
  45. Neuroprotective strategies in seizure-induced damage
    JANA VELISKOVA; Fiscal Year: 2011
    ..of gender-specific expression of such processes as depression/anxiety, stress processing, memory, and cognition.2-Estradiol has neuroprotective effects in several neurodegenerative diseases including the seizure-induced ..
  46. BDNF-Estrogen Interactions with Perimenopausal Mood and Cognition
    Elizabeth M Waters; Fiscal Year: 2012
    ..These studies will provide information on the interaction of estrogen and BDNF in affective disorders and could lead to improved hormone replacement therapies to alleviate menopausal symptoms. ..
  47. Cerebrovascular Disease and its Consequences in the Strong Study Cohort
    Dedra S Buchwald; Fiscal Year: 2013
    ..were not, however, benign accompaniments of aging as they were associated with impaired motor function and cognition, depression, and a striking increase in the risk of subsequent stroke and death...
  48. Noncoding RNAs as epigenomic modulators in Alzheimer's Disease
    CLAES ROBERT WAHLESTEDT; Fiscal Year: 2010
    ..disease is a devastating age-related neurodegenerative disorder characterized by progressive impairment of cognition and short-term memory loss...
  49. Regulation of 22q11 Genes in Embroyonic and Adult Forebrain
    Anthony S LaMantia; Fiscal Year: 2013
    ..Syndrome) occurs in approximately 1/3000 live births and confers increased vulnerability for language and social cognition deficits, attention deficit/hyperactivity disorder, autism, mood disorders, and schizophrenia...
  50. The role of diet-induced obesity in cognitive impairment
    CATRINA SIMS ROBINSON; Fiscal Year: 2013
    ..have demonstrated that improving insulin signaling in the central nervous system (CNS) has a positive impact on cognition;however, obese individuals are excluded from such studies...
  51. Outcomes and Predictors in Mild Cognitive Impairment
    Mary Ganguli; Fiscal Year: 2012
    ..Apo A1, ApoB, homocysteine, C-Reactive Protein, and cystatin) from subgroups of participants with normal cognition and with subtypes of MCI...
  52. Adolescent brains, nicotine and endogenous prototoxins
    Rae Nishi; Fiscal Year: 2010
    ..Grant is a multidisciplinary approach that involves investigators from the fields of animal behavior, human cognition, genetic epidemiology, and molecular cell biology to test the validity of the following model: that the enhanced ..
    Susan K McConnell; Fiscal Year: 2013
    ..Defects in the formation and elaboration of cortical circuits have fundamental implications for vision, cognition, and mental health, since defects in the migration and connectivity of cortical neurons are associated with a ..
  54. miR132 regulation of neuronal plasticity, learning, and memory
    KATELIN L F HANSEN; Fiscal Year: 2013
    ..Thus, the functional role of miRNAs in nervous system physiology and cognition merits close examination...
  55. CRCNS: Theory and experiment of neural circuit mapping by DNA sequencing
    Anthony M Zador; Fiscal Year: 2013
    ..A wide range of brain functions, including sensory perception, learning, memory, decision making, cognition, reasoning, and communication, is therefore related to the details of this neuronal connectivity...
  56. Molecular-Genetic Dissection of Basal Forebrain Circuitry Regulating Arousal
    PATRICK MICHAEL FULLER; Fiscal Year: 2013
    ..complex brain region that is implicated in a wide range of higher-level neurobiological processes including, cognition, learning, memory and attention, virtually all of which operate on a basis of wakefulness...
  57. Nicotinic receptor stimulation and epigenetic regulation of GABAergic function.
    Alessandro Guidotti; Fiscal Year: 2013
    ..antagonist drugs (typical or atypical neuroleptics) has an antipsychotic effect, but negative symptoms and cognition are not significantly improved...
  58. Endocannabinoid Discrimination
    Jenny L Wiley; Fiscal Year: 2013
    ..g., brain reward, appetite regulation, cognition)...
  59. Inhibition of HIV-Induced Synaptodentritic Damage
    Val S Goodfellow; Fiscal Year: 2013
    ..Damage to synaptic architecture is the key pathological process of HAND in cognition and memory impairment...
  60. Endocannabinoid Intracellular Transporters
    Dale G Deutsch; Fiscal Year: 2010 a new drug target drug target may lead to treatment for addiction, mood disorders, pain and inflammation, cognition, and appetite regulation...
  61. Measuring Altered Social Behavior in Neurodegenerative Disease
    Katherine P Rankin; Fiscal Year: 2013
    ..The specific aim of this project is to adapt existing measures of social cognition for reliable and valid use in neurodegenerative diseases...
  62. Hypothalamic autophagy and metabolic regulation in aging
    Rajat Singh; Fiscal Year: 2013
    ..through one of many adverse effects on cardio- and cerebrovascular health, locomotor activity, vision and cognition, as well as on the development of tumors...
  63. Long Term Outcomes in ICU Patients: Delirium & Apolipoprotein E
    Sheila Alexander; Fiscal Year: 2009
    Delirium and Apolipoprotein Delirium, a disturbance is consciousness with inattention accompanied by a change in cognition or perceptual disturbances, is a common occurrence in hospitalized patients in and out of the ICU...
  64. Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring Study
    Jacob Selhub; Fiscal Year: 2010
    ..Few previous studies of cognition investigated the interaction between vitamin B12 status and folate status, and most that looked at the main- ..
  65. Social Cognition and Functioning in Bipolar Disorder
    Michael F Green; Fiscal Year: 2010
    ..An extensive literature in schizophrenia research has established that basic (non-social) cognition is a key determinant of functional outcome in schizophrenia and that social cognition acts as a mediator between ..
  66. Remediation of Working Memory in Schizophrenia
    Tasha Nienow; Fiscal Year: 2009
    ..The proposed intervention study is designed to enhance cognition and psychosocial functioning in patients...
  67. Young Development of a Novel PET Ligand for Detecting Oxytocin Receptors in Brain
    Larry J Young; Fiscal Year: 2012
    ..provided by applicant): Oxytocin (OT) is a neuropeptide that has been implicated in the regulation of social cognition and social behavior both in animal models and in humans...
  68. Brain-Based Measures for Treatment Development of Impaired Cognition in Schizophr
    Cameron S Carter; Fiscal Year: 2010
    ..the past decade there has been a growing awareness of the disabling and treatment refractory effects of impaired cognition in schizophrenia, which results in performance deficits that are strongly and consistently related to poor ..
  69. Aging, Social Interdependence and Wisdom in the U.S. and Japan
    Richard E Nisbett; Fiscal Year: 2010
    ..older people are more interdependent than younger people and (2) as a consequence, they become more holistic in cognition, and (3) in part as a result of more holistic thinking, they become wiser in some respects...
    Judith Ross; Fiscal Year: 2007
    ..a unique, sex hormone-deficient model in which to study the biological effects of androgen treatment on cognition and behavior in females...
  71. Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition
    Susan A Korrick; Fiscal Year: 2010
    ..of early life exposure to neurotoxic metal mixtures, and their interactions, with early adolescent behavior and cognition. The metals to be studied are prenatal manganese (Mn), methylmercury (MeHg), arsenic (As), lead (Pb) and ..
  72. A Study of Narrative as the Cognitivie Process Underlying Diagnostic Reasoning
    CURTIS SCOTT SMITH; Fiscal Year: 2010
    ..Studies in cognitive science and social psychology suggest that narrative cognition integrates these two processes. The role of narrative cognition in medical diagnosis is not well understood...
    MONICA STARKMAN; Fiscal Year: 2001
    ..Patients with CD exhibit hypercortisolemia and develop disturbances in mood, sleep, libido, and cognition. The investigator's hypothesis is that steroid elevations in these various conditions have important neuroactive ..
  74. Cognitive Decline and Dementia: Life Experiences and the Brain Histone Epigenome
    David A Bennett; Fiscal Year: 2010
    ..cerebrovascular disease, and Lewy body disease, these conditions only account for about 20% of the variance of cognition in older persons...
    Richard McNally; Fiscal Year: 1991
    ..Unfortunately, most cognitive research has relied solely on patient self-report as the sole measure of cognition. Investigators have yet to apply the experimental paradigms of cognitive psychology to study cognition and panic...
    Allyson Washburn; Fiscal Year: 1999
    ..proposed pilot work is preliminary to a longitudinal study of the relationships among social behavior, social cognition, and general cognitive status in dementia patients and in a group of controls matched for age, gender, and ..
    HAYNE REESE; Fiscal Year: 1990
    ..provide a unique integration of theoretical perspectives, methodology, and data on the mechanisms of everyday cognition across the life-span...