Genomes and Genes
Summary: Intellectual or mental process whereby an organism becomes aware of or obtains knowledge.
Publications302 found, 100 shown here
- An integrative theory of prefrontal cortex functionE K Miller
Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Annu Rev Neurosci 24:167-202. 2001..We review neurophysiological, neurobiological, neuroimaging, and computational studies that support this theory and discuss its implications as well as further issues to be addressed..
- Functional connectivity in the resting brain: a network analysis of the default mode hypothesisMichael D Greicius
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5719, USA
Proc Natl Acad Sci U S A 100:253-8. 2003..Our findings also provide insight into how this network is modulated by task demands and what functions it might subserve...
- The role of the medial frontal cortex in cognitive controlK Richard Ridderinkhof
Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, Netherlands
Science 306:443-7. 2004....
- The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysisA Miyake
Department of Psychology, University of Colorado at Boulder, 80309-0345, USA
Cogn Psychol 41:49-100. 2000..These results suggest that it is important to recognize both the unity and diversity of executive functions and that latent variable analysis is a useful approach to studying the organization and roles of executive functions...
- Anterior cingulate conflict monitoring and adjustments in controlJohn G Kerns
Department of Psychological Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA
Science 303:1023-6. 2004....
- Conflict monitoring and anterior cingulate cortex: an updateMatthew M Botvinick
University of Pennsylvania, Center for Cognitive Neuroscience, 3720 Walnut Street, Philadelphia, PA 10104 6241, USA
Trends Cogn Sci 8:539-46. 2004..Recent research has also begun to shed light on the larger function of the ACC, suggesting some new possibilities concerning how conflict monitoring might fit into the cingulate's overall role in cognition and action.
- Towards a cognitive neuroscience of consciousness: basic evidence and a workspace frameworkS Dehaene
Unité INSERM 334, Service Hospitalier Frederic Joliot, CEA DRM DSV, 4, place du General Leclerc, 91401 Cedex, Orsay, France
Cognition 79:1-37. 2001..Neurophysiological, anatomical, and brain-imaging data strongly argue for a major role of prefrontal cortex, anterior cingulate, and the areas that connect to them, in creating the postulated brain-scale workspace...
- A default mode of brain function: a brief history of an evolving ideaMarcus E Raichle
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuroimage 37:1083-90; discussion 1097-9. 2007..Most critically, this work has called attention to the importance of intrinsic functional activity in assessing brain behavior relationships...
- Relating introspective accuracy to individual differences in brain structureStephen M Fleming
Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N 3BG, UK
Science 329:1541-3. 2010..Our findings point to a focal neuroanatomical substrate for introspective ability, a substrate distinct from that supporting primary perception...
- Large-scale brain networks in cognition: emerging methods and principlesSteven L Bressler
Center for Complex Systems and Brain Sciences, Department of Psychology, Florida Atlantic University, Boca Raton, FL, USA
Trends Cogn Sci 14:277-90. 2010An understanding of how the human brain produces cognition ultimately depends on knowledge of large-scale brain organization...
- Anterior cingulate cortex, error detection, and the online monitoring of performanceC S Carter
Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Science 280:747-9. 1998..This suggests that the ACC detects conditions under which errors are likely to occur rather than errors themselves...
- The architecture of cognitive control in the human prefrontal cortexEtienne Koechlin
Institut National de la Sante et de Recherche Medicale, Universite Pierre et Marie Curie, 9, quai St Bernard, 75005 Paris, France
Science 302:1181-5. 2003..The results support an unified modular model of cognitive control that describes the overall functional organization of the human lateral PFC and has basic methodological and theoretical implications...
- Wandering minds: the default network and stimulus-independent thoughtMalia F Mason
Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA
Science 315:393-5. 2007..of human minds to wander, little is known about the neural operations that support this core component of human cognition. Using both thought sampling and brain imaging, the current investigation demonstrated that mind-wandering is ..
- The structural basis of inter-individual differences in human behaviour and cognitionRyota Kanai
The UCL Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
Nat Rev Neurosci 12:231-42. 2011..We propose that inter-individual differences can be used as a source of information to link human behaviour and cognition to brain anatomy.
- Changes in cortical dopamine D1 receptor binding associated with cognitive trainingFiona McNab
Neuropediatric Unit, Department of Woman and Child Health, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
Science 323:800-2. 2009Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission...
- Neurophysiological and computational principles of cortical rhythms in cognitionXiao Jing Wang
Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Physiol Rev 90:1195-268. 2010..This review focuses on oscillations in the cerebral cortex that occur during cognition, in alert behaving conditions...
- The processing-speed theory of adult age differences in cognitionT A Salthouse
Georgia Institute of Technology, Atlanta 30332 0170, USA
Psychol Rev 103:403-28. 1996A theory is proposed to account for some of the age-related differences reported in measures of Type A or fluid cognition. The central hypothesis in the theory is that increased age in adulthood is associated with a decrease in the speed ..
- Grounded cognitionLawrence W Barsalou
Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
Annu Rev Psychol 59:617-45. 2008Grounded cognition rejects traditional views that cognition is computation on amodal symbols in a modular system, independent of the brain's modal systems for perception, action, and introspection...
- A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networksDevarajan Sridharan
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 105:12569-74. 2008..Our findings have important implications for a unified view of network mechanisms underlying both exogenous and endogenous cognitive control...
- Frames, biases, and rational decision-making in the human brainBenedetto De Martino
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1 3AR, UK
Science 313:684-7. 2006..This finding highlights the importance of incorporating emotional processes within models of human choice and suggests how the brain may modulate the effect of these biasing influences to approximate rationality...
- Effects of cognitive training interventions with older adults: a randomized controlled trialKarlene Ball
Department of Psychology, University of Alabama at Birmingham, 35294 2100, USA
JAMA 288:2271-81. 2002..However, few studies have addressed whether improving cognitive functions might have short- or long-term effects on activities related to living independently...
- An application of prefrontal cortex function theory to cognitive agingR L West
Department of Psychology, University of South Carolina, USA
Psychol Bull 120:272-92. 1996..I found the frontal lobe hypothesis to perform well, with the exception of an inability to account for age-related declines in item recall and recognition memory, possibly a result of age-related declines in medial temporal function...
- High gamma power is phase-locked to theta oscillations in human neocortexR T Canolty
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
Science 313:1626-8. 2006..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...
- Long-term effects of cognitive training on everyday functional outcomes in older adultsSherry L Willis
Department of Human Development and Family Studies, Pennsylvania State University, State College, PA 16801
JAMA 296:2805-14. 2006..Cognitive training has been shown to improve cognitive abilities in older adults but the effects of cognitive training on everyday function have not been demonstrated...
- An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performanceGary Aston-Jones
Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Annu Rev Neurosci 28:403-50. 2005..We propose that these frontal areas produce the above patterns of LC activity to optimize utility on both short and long timescales...
- Understanding and sharing intentions: the origins of cultural cognitionMichael Tomasello
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Behav Brain Sci 28:675-91; discussion 691-735. 2005We propose that the crucial difference between human cognition and that of other species is the ability to participate with others in collaborative activities with shared goals and intentions: shared intentionality...
- The locus coeruleus and noradrenergic modulation of cognitionSusan J Sara
CNRS UMR 7152, College de France, Paris 75005, France
Nat Rev Neurosci 10:211-23. 2009....
- Gaze cueing of attention: visual attention, social cognition, and individual differencesAlexandra Frischen
Macquarie Centre for Cognitive Science, Macquarie University, Sydney, NSW, Australia
Psychol Bull 133:694-724. 2007..The contribution of this paradigm has been significant and will likely continue to advance knowledge across diverse fields within psychology and neuroscience...
- Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial AbetaPaul A Adlard
Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
Neuron 59:43-55. 2008..The speed of recovery of the animals underscores the acutely reversible nature of the cognitive deficits associated with transgenic models of AD...
- Six views of embodied cognitionMargaret Wilson
Department of Psychology, University of California, Santa Cruz, CA 95064, USA
Psychon Bull Rev 9:625-36. 2002The emerging viewpoint of embodied cognition holds that cognitive processes are deeply rooted in the body's interactions with the world...
- A unifying view of the basis of social cognitionVittorio Gallese
Department of Neuroscience, Section of Physiology, University of Parma, Italy
Trends Cogn Sci 8:396-403. 2004..A similar mechanism, but involving the activation of viscero-motor centers, underlies the experiential understanding of the emotions of others...
- Disruption of large-scale brain systems in advanced agingJessica R Andrews-Hanna
Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
Neuron 56:924-35. 2007..accompanied by disruptive alterations in the coordination of large-scale brain systems that support high-level cognition. In 93 adults aged 18 to 93, we demonstrate that aging is characterized by marked reductions in normally present ..
- Dual-processing accounts of reasoning, judgment, and social cognitionJonathan St B T Evans
Center for Thinking and Language, School of Psychology, University of Plymouth, Plymouth PL4 8AA, United Kingdom, USA
Annu Rev Psychol 59:255-78. 2008This article reviews a diverse set of proposals for dual processing in higher cognition within largely disconnected literatures in cognitive and social psychology...
- Anterior prefrontal function and the limits of human decision-makingEtienne Koechlin
Institut National de la Sante et de la Recherche Medicale, Departement d Etudes Cognitives, Ecole Normale Superieure, Universite Pierre et Marie Curie, 9, quai Saint Bernard, 75005 Paris, France
Science 318:594-8. 2007....
- For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotionKevin N Ochsner
Department of Psychology, Columbia University, 369 Schermerhorn Hall, New York, NY 10027, USA
Neuroimage 23:483-99. 2004....
- Effects of stress throughout the lifespan on the brain, behaviour and cognitionSonia J Lupien
Universite de Montreal, Mental Health Research Centre, Fernand Seguin Hôpital Louis H Lafontaine, Quebec, Canada
Nat Rev Neurosci 10:434-45. 2009..period, infancy, childhood, adolescence, adulthood or aging, has an impact on brain structures involved in cognition and mental health...
- Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled studyHenry W Mahncke
Posit Science Corporation, 225 Bush Street, San Francisco, CA 94104, USA
Proc Natl Acad Sci U S A 103:12523-8. 2006Normal aging is associated with progressive functional losses in perception, cognition, and memory...
- Evidence for a frontoparietal control system revealed by intrinsic functional connectivityJustin L Vincent
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
J Neurophysiol 100:3328-42. 2008..The frontoparietal control system is therefore anatomically positioned to integrate information from these two opposing brain systems...
- Default network activity, coupled with the frontoparietal control network, supports goal-directed cognitionR Nathan Spreng
Department of Psychology, Harvard University, Cambridge MA 02138, USA
Neuroimage 53:303-17. 2010..Consequently, many assume that default network activity is suppressed during goal-directed cognition. We challenge this assumption in an fMRI study of planning...
- The role of the right temporoparietal junction in social interaction: how low-level computational processes contribute to meta-cognitionJean Decety
Department of Psychology, and Center for Cognitive and Social Neuroscience, The University of Chicago, Chicago, IL 60637, USA
Neuroscientist 13:580-93. 2007..cortex, at the junction with the posterior temporal cortex, plays a critical role in various aspects of social cognition such as theory of mind and empathy...
- Toward a neurobiology of temporal cognition: advances and challengesJ Gibbon
Department of Biopsychology, New York State Psychiatric Institute, Box 50, 722 West 168th Street, New York, NY 10032, USA
Curr Opin Neurobiol 7:170-84. 1997..We propose that cerebellar dysfunction may induce deregulation of tonic thalamic tuning, which disrupts gating of the mnemonic temporal information generated in the basal ganglia through striato-thalamo-cortical loops...
- Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotionChristopher Barkus
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
Eur J Pharmacol 626:49-56. 2010..Wied had a fundamental interest in the brain and behaviour, with a particular interest in the interface between cognition and emotion, and how impairments at this interface could underlie human psychopathology...
- Cognitive reserveYaakov Stern
Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, United States
Neuropsychologia 47:2015-28. 2009..It then focuses on methodologic issues that are important when attempting to elucidate the neural underpinnings of cognitive reserve using imaging studies, and reviews some of our group's work in order to demonstrate these issues...
- Value computations in ventral medial prefrontal cortex during charitable decision making incorporate input from regions involved in social cognitionTodd A Hare
Computation and Neural Systems and Humanities and Social Science Divisions, California Institute of Technology, Pasadena, California 91125 7700, USA
J Neurosci 30:583-90. 2010..functional connectivity analyses indicated that the value signal in VMPFC might integrate inputs from networks, including the anterior insula and posterior superior temporal cortex, that are thought to be involved in social cognition.
- Social cognition and the brain: a meta-analysisFrank Van Overwalle
Department of Psychology, Vrije Universiteit Brussel, Brussel, Belgium
Hum Brain Mapp 30:829-58. 2009This meta-analysis explores the location and function of brain areas involved in social cognition, or the capacity to understand people's behavioral intentions, social beliefs, and personality traits...
- Neural mechanisms of transient and sustained cognitive control during task switchingTodd S Braver
Department of Psychology, Washington University, St Louis, MO 63130, USA
Neuron 39:713-26. 2003....
- Storage and executive processes in the frontal lobesE E Smith
Department of Psychology, Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 1109, USA
Science 283:1657-61. 1999..Two of the fundamental executive processes are selective attention and task management. Both processes activate the anterior cingulate and dorsolateral prefrontal cortex...
- The neural basis of economic decision-making in the Ultimatum GameAlan G Sanfey
Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
Science 300:1755-8. 2003..Unfair offers elicited activity in brain areas related to both emotion (anterior insula) and cognition (dorsolateral prefrontal cortex)...
- Individual differences in non-verbal number acuity correlate with maths achievementJustin Halberda
Johns Hopkins University, Ames Hall, 3400 North Charles Street, Baltimore, Maryland 21218, USA
Nature 455:665-8. 2008..Further research will determine whether early differences in number sense acuity affect later maths learning, whether maths education enhances number sense acuity, and the extent to which tertiary factors can affect both...
- Constructive and unconstructive repetitive thoughtEdward R Watkins
Mood Disorders Centre, School of Psychology, University of Exeter, Washington Singer Laboratories, UK
Psychol Bull 134:163-206. 2008..concrete processing) adopted during RT. Of the existing models of RT, it is proposed that an elaborated version of the control theory account provides the best theoretical framework to account for its distinct consequences...
- Temporal dynamics of brain activation during a working memory taskJ D Cohen
Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Nature 386:604-8. 1997..We used the temporal resolution of this technique to examine the dynamics of regional activation, and to show that prefrontal cortex along with parietal cortex appears to play a role in active maintenance...
- A neural basis for social cooperationJames Rilling
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
Neuron 35:395-405. 2002..We propose that activation of this neural network positively reinforces reciprocal altruism, thereby motivating subjects to resist the temptation to selfishly accept but not reciprocate favors...
- Structural dynamics of dendritic spines in memory and cognitionHaruo Kasai
Laboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, and Center for NanoBio Integration, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
Trends Neurosci 33:121-9. 2010..Spine dynamics are also implicated in long-term memory and cognition: intrinsic fluctuations in volume can explain synapse maintenance over long periods, and rapid, activity-..
- Exercise: a behavioral intervention to enhance brain health and plasticityCarl W Cotman
Institute for Brain Aging and Dementia, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 4540, USA
Trends Neurosci 25:295-301. 2002..Thus, exercise could provide a simple means to maintain brain function and promote brain plasticity...
- Two views of brain functionMarcus E Raichle
Departments of Radiology, Neurology, Neurobiology and Biomedical Engineering, Washington University School of Medicine, 4525 Scott Avenue, Room 2116, St Louis, MO 63110, USA
Trends Cogn Sci 14:180-90. 2010....
- Modes and models of forebrain cholinergic neuromodulation of cognitionMichael E Hasselmo
Center for Memory and Brain, Department of Psychology, Boston University, Boston, MA 02215, USA
Neuropsychopharmacology 36:52-73. 2011..The available evidence and these models point to new principles governing the development of the next generation of cholinergic treatments for cognitive disorders...
- Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometryMarcel Adam Just
Center for Cognitive Brain Imaging, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Cereb Cortex 17:951-61. 2007..These findings suggest that the neural basis of altered cognition in autism entails a lower degree of integration of information across certain cortical areas resulting from ..
- Learned predictions of error likelihood in the anterior cingulate cortexJoshua W Brown
Department of Psychology, CB 1125, Washington University, St Louis, MO 63130, USA
Science 307:1118-21. 2005..These results support a more general error-likelihood theory of ACC function based on reinforcement learning, of which conflict and error detection are special cases...
- Conscious intention and motor cognitionPatrick Haggard
Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
Trends Cogn Sci 9:290-5. 2005..Both intention and agency result from the brain processes for predictive motor control, not merely from retrospective inference...
- Lateral prefrontal cortex: architectonic and functional organizationMichael Petrides
Montreal Neurological Institute and Department of Psychology, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
Philos Trans R Soc Lond B Biol Sci 360:781-95. 2005....
- Enhanced perceptual functioning in autism: an update, and eight principles of autistic perceptionLaurent Mottron
Pervasive Developmental Disorders Specialized Clinic, Riviere des Prairies Hospital, and Fernand Seguin Research Center, University of Montreal, Canada
J Autism Dev Disord 36:27-43. 2006..The overfunctioning of brain regions typically involved in primary perceptual functions may explain the autistic perceptual endophenotype...
- The role of sleep in cognition and emotionMatthew P Walker
Sleep and Neuroimaging Laboratory, Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 1650, USA
Ann N Y Acad Sci 1156:168-97. 2009As critical as waking brain function is to cognition, an extensive literature now indicates that sleep supports equally important, different yet complementary operations...
- Attentional sensitization of unconscious cognition: task sets modulate subsequent masked semantic primingMarkus Kiefer
Department of Psychiatry, Univerity of Ulm, Ulm, Germany
J Exp Psychol Gen 139:464-89. 2010..Hence, automatic processing of unconscious stimuli is susceptible to top-down control for optimizing goal-related information processing...
- On the relationship between emotion and cognitionLuiz Pessoa
Department of Psychological and Brain Sciences, and Programs in Neuroscience and Cognitive Science, Indiana University, Bloomington, Indiana 47405, USA
Nat Rev Neurosci 9:148-58. 2008..Popular examples are the amygdala in the domain of emotion and the lateral prefrontal cortex in the case of cognition. This prevalent view is problematic for a number of reasons...
- Can social interaction constitute social cognition?Hanne De Jaegher
Marie Curie Project DISCOS, Department of Psychiatry, University of Heidelberg, Vossstrasse 4, D 69115 Heidelberg, Germany
Trends Cogn Sci 14:441-7. 2010An important shift is taking place in social cognition research, away from a focus on the individual mind and toward embodied and participatory aspects of social understanding...
- Joint action: bodies and minds moving togetherNatalie Sebanz
Rutgers, The State University of New Jersey, Psychology Department, Smith Hall, 101 Warren Street, Newark, NJ 07102, USA
Trends Cogn Sci 10:70-6. 2006..Several mechanisms are proposed that allow individuals to share representations, to predict actions, and to integrate predicted effects of own and others' actions...
- What does the amygdala contribute to social cognition?Ralph Adolphs
California Institute of Technology, Pasadena, California 91125, USA
Ann N Y Acad Sci 1191:42-61. 2010..These aspects help to clarify the amygdala's contributions to recognizing emotion from faces, to social behavior toward conspecifics, and to reward learning and instrumental behavior...
- Electroencephalographic signatures of attentional and cognitive default modes in spontaneous brain activity fluctuations at restH Laufs
Cognitive Neurology Unit, Department of Neurology, J. W. Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany
Proc Natl Acad Sci U S A 100:11053-8. 2003....
- Cognitive control, hierarchy, and the rostro-caudal organization of the frontal lobesDavid Badre
Department of Cognitive and Linguistic Sciences, Brown University, Box 1978, Providence, RI 02912 1978, USA
Trends Cogn Sci 12:193-200. 2008..Distinctions among these frameworks are considered as a basis for future research...
- Left ventrolateral prefrontal cortex and the cognitive control of memoryDavid Badre
Helen Wills Neuroscience Institute, 132 Barker Hall, MC3190, UC Berkeley, CA 94720 3190, USA
Neuropsychologia 45:2883-901. 2007..Finally, we consider open directions for future research into left VLPFC function and the cognitive control of memory...
- Emotion and cognition: insights from studies of the human amygdalaElizabeth A Phelps
Department of Psychology, New York University, New York, New York 10003, USA
Annu Rev Psychol 57:27-53. 2006Traditional approaches to the study of cognition emphasize an information-processing view that has generally excluded emotion...
- Epigenetic mechanisms in cognitionJeremy J Day
Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
Neuron 70:813-29. 2011..Finally, we consider how aberrant epigenetic modifications may lead to cognitive disorders that affect learning and memory, and we review the therapeutic potential of epigenetic treatments for the amelioration of these conditions...
- Can cognitive processes be inferred from neuroimaging data?Russell A Poldrack
Department of Psychology and Brain Research Institute, UCLA, Los Angeles, CA 90095 1563, USA
Trends Cogn Sci 10:59-63. 2006There is much interest currently in using functional neuroimaging techniques to understand better the nature of cognition. One particular practice that has become common is 'reverse inference', by which the engagement of a particular ..
- Perceptual symbol systemsL W Barsalou
Department of Psychology, Emory University, Atlanta, GA 30322, USA
Behav Brain Sci 22:577-609; discussion 610-60. 1999..Implications for cognition, neuroscience, evolution, development, and artificial intelligence are explored.
- Time perception: manipulation of task difficulty dissociates clock functions from other cognitive demandsAlexandra C Livesey
Department of Psychology, Royal Holloway, University of London, Egham, UK
Neuropsychologia 45:321-31. 2007..We argue that the extent of the timing "network" has been significantly over-estimated in the past and that only these three relatively small regions can safely be regarded as being directly concerned with duration judgements...
- The brainweb: phase synchronization and large-scale integrationF Varela
Laboratoire de Neurosciences Cognitives et Imagerie Cerebrale, Hopital de la Salpetriere, Paris 47 Boulevard de l Hôpital, 75651 Paris Cedex 13, France
Nat Rev Neurosci 2:229-39. 2001..anatomical and functional organization of brain activity to enable the emergence of coherent behaviour and cognition. Although the mechanisms involved in large-scale integration are still largely unknown, we argue that the most ..
- The cognitive control of emotionKevin N Ochsner
Department of Psychology, Columbia University, Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10027, USA
Trends Cogn Sci 9:242-9. 2005..Taken together, the results suggest a functional architecture for the cognitive control of emotion that dovetails with findings from other human and nonhuman research on emotion...
- Triangulating a cognitive control network using diffusion-weighted magnetic resonance imaging (MRI) and functional MRIAdam R Aron
Department of Psychology, University of California San Diego, La Jolla, California 92093, USA
J Neurosci 27:3743-52. 2007..The results also demonstrate a three-way functional-anatomical network in the right hemisphere that could either brake or completely stop responses...
- From sensation to cognitionM M Mesulam
Department of Neurology, Northwestern University Medical School, Chicago 60611, USA
Brain 121:1013-52. 1998..extensive associative elaboration and attentional modulation as it becomes incorporated into the texture of cognition. This process occurs along a core synaptic hierarchy which includes the primary sensory, upstream unimodal, ..
- Neuroscience. Transient dynamics for neural processingMisha Rabinovich
Institute for Nonlinear Science, University of California at San Diego, La Jolla, CA 92093, USA
Science 321:48-50. 2008
- Social cognition and the evolution of language: constructing cognitive phylogeniesW Tecumseh Fitch
Department of Cognitive Biology, Althanstrasse 14, University of Vienna, A 1090 Vienna, Austria
Neuron 65:795-814. 2010Human language and social cognition are closely linked: advanced social cognition is necessary for children to acquire language, and language allows forms of social understanding (and, more broadly, culture) that would otherwise be ..
- Treatment adherence in multiple sclerosis: association with emotional status, personality, and cognitionJared M Bruce
Department of Psychology, University of Missouri Kansas City, 4825 Troost Building, Suite 111G, Kansas City, MO 64110, USA
J Behav Med 33:219-27. 2010..Pharmacological or psychotherapeutic treatment of mood/anxiety disorders, use of scheduled reminders, and/or increased organization and structure may lead to improved treatment adherence in MS...
- Neurogenetics and pharmacology of learning, motivation, and cognitionMichael J Frank
Department of Cognitive, Linguistic and Psychological Sciences, Brown Institute for Brain Science, Brown University, Providence, RI 02912 1978, USA
Neuropsychopharmacology 36:133-52. 2011Many of the individual differences in cognition, motivation, and learning-and the disruption of these processes in neurological conditions-are influenced by genetic factors...
- Self-referential cognition and empathy in autismMichael V Lombardo
Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
PLoS ONE 2:e883. 2007..We aimed to evaluate across several well validated measures in both domains, whether both self-referential cognition and empathy are impaired in ASC and whether these two domains are related to each other.
- Optimal predictions in everyday cognitionThomas L Griffiths
Department of Cognitive and Linguistic Sciences, Brown University, RI 02912, USA
Psychol Sci 17:767-73. 2006..We examined the optimality of human cognition in a more realistic context than typical laboratory studies, asking people to make predictions about the ..
- White matter integrity and cognition in childhood and old ageI J Deary
Department of Psychology, School of Philosophy, Psychology, and Language Sciences, University of Edinburgh, UK
Neurology 66:505-12. 2006..To test the hypothesis that white matter integrity, as measured by diffusion tensor and magnetization transfer MRI is significantly associated with cognitive ability measured in youth and old age...
- Constraining theories of embodied cognitionArthur B Markman
Department of Psychology, University of Texas, Austin, TX 78712, USA
Psychol Sci 16:6-10. 2005Influences of perceptual and motor activity on evaluation have led to theories of embodied cognition suggesting that putatively complex judgments can be carried out using only perceptual and motor representations...
- An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivoDaniel B Timmermann
Neurosearch A S, Ballerup, Denmark
J Pharmacol Exp Ther 323:294-307. 2007..These data support the notion that alpha7 nAChR allosteric modulation may constitute a novel pharmacological principle for the treatment of cognitive dysfunction...
- Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studiesJeffrey R Binder
Language Imaging Laboratory, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Cereb Cortex 19:2767-96. 2009....
- Physical and motor fitness are both related to cognition in old ageClaudia Voelcker-Rehage
Jacobs Center on Lifelong Learning and Institutional Development, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany
Eur J Neurosci 31:167-76. 2010..Results are discussed with regard to the compensation hypothesis and potential consequences for intervention work...
- Political conservatism as motivated social cognitionJohn T Jost
Graduate School of Business, Stanford University, California 94305, USA
Psychol Bull 129:339-75. 2003Analyzing political conservatism as motivated social cognition integrates theories of personality (authoritarianism, dogmatism-intolerance of ambiguity), epistemic and existential needs (for closure, regulatory focus, terror management), ..
- Impact of aging on hippocampal function: plasticity, network dynamics, and cognitionEphron S Rosenzweig
Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, AZ, USA
Prog Neurobiol 69:143-79. 2003..Further studies of the aged hippocampus will not only lead to treatments for age-related cognitive impairments, but may also clarify the mechanisms of learning in adult mammals...
- Be smart, exercise your heart: exercise effects on brain and cognitionCharles H Hillman
Charles H Hillman is at the Department of Kinesiology and Community Health, 213 Louise Freer Hall, 906 South Goodwin Avenue, University of Illinois, Urbana, Illinois 61801, USA
Nat Rev Neurosci 9:58-65. 2008..Human and non-human animal studies have shown that aerobic exercise can improve a number of aspects of cognition and performance...
- Sleep inspires insightUllrich Wagner
Department of Neuroendocrinology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
Nature 427:352-5. 2004..We conclude that sleep, by restructuring new memory representations, facilitates extraction of explicit knowledge and insightful behaviour...
- The interplay of cognition and cooperationSarah F Brosnan
Department of Psychology, Georgia State University, Atlanta, GA, USA
Philos Trans R Soc Lond B Biol Sci 365:2699-710. 2010..This paper spans the literature from bacteria to humans in our search for the key variables that link cooperation and deception to cognition.
- The effect of modified jazz dance on balance, cognition, and mood in older adultsPatricia T Alpert
Department of Physiologic Nursing, School of Nursing, University of Nevada Las Vegas, 4505 Maryland Parkway, Las Vegas, NV 89154 3018, USA
J Am Acad Nurse Pract 21:108-15. 2009The purpose of this pilot study was to evaluate the impact of jazz dance class instruction on balance, cognition, and mood (specifically depression) in 13 healthy, community-dwelling, English-speaking older women with a mean age of 68.
- The role of the human anterior insular cortex in time processingP Kosillo
Department of Psychology, Royal Holloway University of London, Egham, TW20 0EX, UK
Brain Struct Funct 214:623-8. 2010..Other structures may be more strongly associated with core timing functions...
- Cognitive functioning ten years following traumatic brain injury and rehabilitationKristy Draper
Monash University, Clayton, Victoria, Australia
Neuropsychology 22:618-25. 2008..Greater injury severity was significantly correlated with poorer test performances across all domains. This study shows that cognitive impairments are present many years following TBI and are associated with injury severity...
- Spatial and object working memory deficits in Parkinson's disease are due to impairment in different underlying processesKatherine L Possin
University of California, San Diego, CA, USA
Neuropsychology 22:585-95. 2008..These results suggest that deficits in working memory for spatial and object information are mediated by distinct cognitive processes in nondemented patients with PD and may differ in their pathophysiological basis...
- A twin study of cognitive function in chronic fatigue syndrome: the effects of sudden illness onsetKeith H Claypoole
Department of Psychology, University of Hawaii, Honolulu, HI, USA
Neuropsychology 21:507-13. 2007..If confirmed, these findings suggest the need to distinguish illness onset in future CFS studies and may have implications for treatment, cognitive rehabilitation, and disability determination...
- Associative knowledge controls deployment of visual selective attentionElisabeth Moores
Department of Neurological and Vision Sciences, Section of Physiology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
Nat Neurosci 6:182-9. 2003..Moreover, in a speeded search protocol, associated objects rendered search both slower and less accurate. Finally, the first saccades after onset of the stimulus array were more often directed toward associated than control items...
- OLDER BREAST CANCER PATIENTS: RISK FOR COGNITIVE DECLINEJeanne Mandelblatt; Fiscal Year: 2009..We use the vulnerability model of cancer survivorship to describe systemic therapy effects on cognition over a 12 month period, test associations between cognition and quality of life and to evaluate whether APOE ..
- OLDER BREAST CANCER PATIENTS: RISK FOR COGNITIVE DECLINERobert A Stern; Fiscal Year: 2010..We use the vulnerability model of cancer survivorship to describe systemic therapy effects on cognition over a 12 month period, test associations between cognition and quality of life and to evaluate whether APOE ..
- Measuring Altered Social Behavior in Neurodegenerative DiseaseKatherine P Rankin; Fiscal Year: 2010..The specific aim of this project is to adapt existing measures of social cognition for reliable and valid use in neurodegenerative diseases...
- Measuring Altered Social Behavior in Neurodegenerative DiseaseKatherine Rankin; Fiscal Year: 2009..The specific aim of this project is to adapt existing measures of social cognition for reliable and valid use in neurodegenerative diseases...
- Long Term Outcomes in ICU Patients: Delirium & Apolipoprotein ESheila Alexander; Fiscal Year: 2009..Delirium and Apolipoprotein Delirium, a disturbance is consciousness with inattention accompanied by a change in cognition or perceptual disturbances, is a common occurrence in hospitalized patients in and out of the ICU...
- Speech of Young Males with Fragile X SyndromeDavid Zajac; Fiscal Year: 2009..among boys with FXS, DS, and TD; and c) identify potential mechanisms (anxiety/arousal, motor speech, nonverbal cognition, attention) that may account for anticipated group differences in speech intelligibility among boys with FXS and ..
- Speech of Young Males with Fragile X SyndromeDavid Zajac; Fiscal Year: 2009..among boys with FXS, DS, and TD; and c) identify potential mechanisms (anxiety/arousal, motor speech, nonverbal cognition, attention) that may account for anticipated group differences in speech intelligibility among boys with FXS and ..
- Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring StudyJacob Selhub; Fiscal Year: 2010..Few previous studies of cognition investigated the interaction between vitamin B12 status and folate status, and most that looked at the main- ..
- Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring StudyJacob Selhub; Fiscal Year: 2009..Few previous studies of cognition investigated the interaction between vitamin B12 status and folate status, and most that looked at the main- ..
- Drug Discovery for Cognitive Impairment Associated with Drugs of AbuseAlvin V Terry; Fiscal Year: 2010Deficits in cognition and working memory accompany several neurological and neuropsychiatric disorders. Effective treatment of these symptoms is of paramount importance for full recovery and for improving medication compliance...
- Exploring the Role of the Brain Epigenome: Cognitive Decline and Life ExperiencesDavid A Bennett; Fiscal Year: 2010..of the proposed project is to explore the role of the epigenome in modulating the effect of life experiences on cognition and dementia in older persons...
- Exploring the Role of the Brain Epigenome: Cognitive Decline and Life ExperiencesDavid Bennett; Fiscal Year: 2009..of the proposed project is to explore the role of the epigenome in modulating the effect of life experiences on cognition and dementia in older persons...
- The Effect of High-Dose Atorvastatin on Neuronal Activity and Cognitive FunctionDonna Polk; Fiscal Year: 2010..Data regarding the effects of statins on cognition are discrepant, although randomized clinical trials have shown either no effect of statins on cognition or even ..
- Aging and Sites of Action of Cognition-Enhancing DrugsDIANA WOODRUFF PAK; Fiscal Year: 2007..classical conditioning model in rabbits will be used to identify sites of action and possible mechanisms for cognition enhancing drugs...
- Aging, Social Interdependence and Wisdom in the U.S. and JapanRichard E Nisbett; Fiscal Year: 2010..older people are more interdependent than younger people and (2) as a consequence, they become more holistic in cognition, and (3) in part as a result of more holistic thinking, they become wiser in some respects...
- Amygdala: sex differences in behavior, cognition, and neuroendocrine developmentKim Wallen; Fiscal Year: 2010The amygdala, a sexually differentiated brain structure intimately involved in emotions, cognition, social behavior, and sexuality, is particularly important in monkeys for recognizing and responding to social context and danger...
- Amygdala: sex differences in behavior, cognition, and neuroendocrine developmentKim Wallen; Fiscal Year: 2009The amygdala, a sexually differentiated brain structure intimately involved in emotions, cognition, social behavior, and sexuality, is particularly important in monkeys for recognizing and responding to social context and danger...
- Amygdala: sex differences in behavior, cognition, and neuroendocrine developmentKim Wallen; Fiscal Year: 2007The amygdala, a sexually differentiated brain structure intimately involved in emotions, cognition, social behavior, and sexuality, is particularly important in monkeys for recognizing and responding to social context and danger...
- Effects of Parkinson's Disease on Perception, Cognition, and GaitALICE M CRONIN GOLOMB; Fiscal Year: 2010Non-motor aspects of Parkinson's disease (PD) such as deficient sensation, perception, and cognition are a source of a significant decline in everyday function and quality of life...
- ANDROGEN EFFECTS ON COGNITION IN TURNER SYNDROMEJudith Ross; Fiscal Year: 2007..a unique, sex hormone-deficient model in which to study the biological effects of androgen treatment on cognition and behavior in females...
- Adolescent Maturation of Brain Network Integration for Executive Control AbilitieMichael Stevens; Fiscal Year: 2009Adolescence is a distinct developmental period during which 'executive' control over behavior and cognition improves towards mature, adult levels of performance on neuropsychological tests...
- Metal and Organochlorines Exposure: Impact on Adolescent Behavior and CognitionSusan A Korrick; Fiscal Year: 2010..of early life exposure to neurotoxic metal mixtures, and their interactions, with early adolescent behavior and cognition. The metals to be studied are prenatal manganese (Mn), methylmercury (MeHg), arsenic (As), lead (Pb) and ..
- Metal and Organochlorines Exposure: Impact on Adolescent Behavior and CognitionSusan Korrick; Fiscal Year: 2009..of early life exposure to neurotoxic metal mixtures, and their interactions, with early adolescent behavior and cognition. The metals to be studied are prenatal manganese (Mn), methylmercury (MeHg), arsenic (As), lead (Pb) and ..
- Metal and Organochlorines Exposure: Impact on Adolescent Behavior and CognitionSusan Korrick; Fiscal Year: 2007..of early life exposure to neurotoxic metal mixtures, and their interactions, with early adolescent behavior and cognition. The metals to be studied are prenatal manganese (Mn), methylmercury (MeHg), arsenic (As), lead (Pb) and ..
- Metal and Organochlorines Exposure: Impact on Adolescent Behavior and CognitionSusan Korrick; Fiscal Year: 2009
- MODELING IN COGNITIONJames Townsend; Fiscal Year: 2007..whom are in the Psychology Department, and are internationally recognized for their expertise in the modeling of cognition; they have contributed some of the major models of cognition in the field, also many important methodological ..
- Vascular Function, Cognition, and Brain MRI in Atherosclerotic Vascular DiseaseDavid Moser; Fiscal Year: 2009..This is the third submission of an R01 requesting five years of funding to support research on vascular disease, cognition, and brain structure in individuals with atherosclerotic vascular disease (AVD) and healthy comparison ..
- COGNITION, STEROIDS AND IMAGING IN CUSHINGS DISEASEMONICA STARKMAN; Fiscal Year: 2001..Patients with CD exhibit hypercortisolemia and develop disturbances in mood, sleep, libido, and cognition. The investigator's hypothesis is that steroid elevations in these various conditions have important neuroactive ..
- Epidemiologic Study of Neural Reserve and Neurobiology of AgingDavid Bennett; Fiscal Year: 2009The ability to maintain cognition despite the accumulation of AD pathology is known as cognitive or neural reserve. Theories of neural reserve include brain reserve capacity, and neural efficiency or compensation, i.e...
- Antipsychotic Influence on Altered MTL Neuronal Activity in SchizophreniaCarol Tamminga; Fiscal Year: 2009..neuronal activity in brain, the rich advances in cognitive neuroscience, and the focus of SZ research on cognition. It is a propitious time to examine mechanisms associated with hippocampal dysfunction in schizophrenia given ..
- Child Health, Cognition, and Behavior: Domain-Specific Estimates of the Effects oRachel A Gordon; Fiscal Year: 2010..between child care quality and child cognitive, behavioral and health outcomes focusing on new domain-specific (cognition, behavior, health) measures of quality...
- Variations in Hormone Therapy: Effects on Cognition and Markers of Brain AgingHeather Bimonte Nelson; Fiscal Year: 2007..However, abundant basic science evidence suggests that estrogens exert beneficial effects on cognition and neurobiological variables related to memory...
- Variations in Hormone Therapy: Effects on Cognition and Markers of Brain AgingHeather Bimonte Nelson; Fiscal Year: 2009..However, abundant basic science evidence suggests that estrogens exert beneficial effects on cognition and neurobiological variables related to memory...
- Variations in Hormone Therapy: Effects on Cognition and Markers of Brain AgingHEATHER ALLYSON BIMONTE NELSON; Fiscal Year: 2010..However, abundant basic science evidence suggests that estrogens exert beneficial effects on cognition and neurobiological variables related to memory...