Research Topics
Genomes and Genes
| cognitionSummarySummary: Intellectual or mental process whereby an organism becomes aware of or obtains knowledge. Top Publications
Research Grants
| Scientific Experts
|
Detail Information
Publications
Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework
S Dehaene
Unité INSERM 334, Service Hospitalier Frederic Joliot, CEA DRM DSV, 4, place du General Leclerc, 91401 Cedex, Orsay, France
Cognition 79:1-37. 2001..Neurophysiological, anatomical, and brain-imaging data strongly argue for a major role of prefrontal cortex, anterior cingulate, and the areas that connect to them, in creating the postulated brain-scale workspace...Anterior cingulate conflict monitoring and adjustments in control
John G Kerns
Department of Psychological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
Science 303:1023-6. 2004....A default mode of brain function: a brief history of an evolving idea
Marcus E Raichle
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuroimage 37:1083-90; discussion 1097-9. 2007..Most critically, this work has called attention to the importance of intrinsic functional activity in assessing brain behavior relationships...Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Michael D Greicius
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5719, USA
Proc Natl Acad Sci U S A 100:253-8. 2003..Our findings also provide insight into how this network is modulated by task demands and what functions it might subserve...Conflict monitoring and cognitive control
M M Botvinick
Department of Psychology, Carnegie Mellon University, Pennsylvania, USA
Psychol Rev 108:624-52. 2001..The second study implements a feedback loop connecting conflict monitoring to cognitive control, using this to simulate a number of important behavioral phenomena...An integrative theory of prefrontal cortex function
E K Miller
Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Annu Rev Neurosci 24:167-202. 2001..We review neurophysiological, neurobiological, neuroimaging, and computational studies that support this theory and discuss its implications as well as further issues to be addressed..Alzheimer's disease is a synaptic failure
Dennis J Selkoe
Center for Neurologic Diseases, Brigham and Women s Hospital, and the Harvard Center for Neurodegeneration and Repair, Boston, MA 02115, USA
Science 298:789-91. 2002....The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis
A Miyake
Department of Psychology, University of Colorado at Boulder, 80309-0345, USA
Cogn Psychol 41:49-100. 2000..These results suggest that it is important to recognize both the unity and diversity of executive functions and that latent variable analysis is a useful approach to studying the organization and roles of executive functions...The brainweb: phase synchronization and large-scale integration
F Varela
Laboratoire de Neurosciences Cognitives et Imagerie Cerebrale, Hopital de la Salpetriere, Paris 47 Boulevard de l Hôpital, 75651 Paris Cedex 13, France
Nat Rev Neurosci 2:229-39. 2001..anatomical and functional organization of brain activity to enable the emergence of coherent behaviour and cognition. Although the mechanisms involved in large-scale integration are still largely unknown, we argue that the most ..Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies
Jeffrey R Binder
Language Imaging Laboratory, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Cereb Cortex 19:2767-96. 2009....The role of the medial frontal cortex in cognitive control
K Richard Ridderinkhof
Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, Netherlands
Science 306:443-7. 2004....Effects of stress throughout the lifespan on the brain, behaviour and cognition
Sonia J Lupien
Universite de Montreal, Mental Health Research Centre, Fernand Seguin Hôpital Louis H Lafontaine, Quebec, Canada
Nat Rev Neurosci 10:434-45. 2009..period, infancy, childhood, adolescence, adulthood or aging, has an impact on brain structures involved in cognition and mental health...Conflict monitoring and anterior cingulate cortex: an update
Matthew M Botvinick
University of Pennsylvania, Center for Cognitive Neuroscience, 3720 Walnut Street, Philadelphia, PA 10104 6241, USA
Trends Cogn Sci 8:539-46. 2004..Recent research has also begun to shed light on the larger function of the ACC, suggesting some new possibilities concerning how conflict monitoring might fit into the cingulate's overall role in cognition and action.Fitness effects on the cognitive function of older adults: a meta-analytic study
Stanley Colcombe
Beckman Institute and Department of Psychology, University of Illinois, Urbana, 61801, USA
Psychol Sci 14:125-30. 2003..Most important fitness training was found to have robust but selective benefits for cognition, with the largest fitness-induced benefits occurring for executive-control processes...A mechanism for cognitive dynamics: neuronal communication through neuronal coherence
Pascal Fries
F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
Trends Cogn Sci 9:474-80. 2005..Thus, a flexible pattern of coherence defines a flexible communication structure, which subserves our cognitive flexibility...Neurophysiological and computational principles of cortical rhythms in cognition
Xiao Jing Wang
Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Physiol Rev 90:1195-268. 2010..This review focuses on oscillations in the cerebral cortex that occur during cognition, in alert behaving conditions...Grounded cognition
Lawrence W Barsalou
Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
Annu Rev Psychol 59:617-45. 2008Grounded cognition rejects traditional views that cognition is computation on amodal symbols in a modular system, independent of the brain's modal systems for perception, action, and introspection...A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks
Devarajan Sridharan
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 105:12569-74. 2008..Our findings have important implications for a unified view of network mechanisms underlying both exogenous and endogenous cognitive control...Wandering minds: the default network and stimulus-independent thought
Malia F Mason
Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA
Science 315:393-5. 2007..of human minds to wander, little is known about the neural operations that support this core component of human cognition. Using both thought sampling and brain imaging, the current investigation demonstrated that mind-wandering is ..Can social interaction constitute social cognition?
Hanne De Jaegher
Marie Curie Project DISCOS, Department of Psychiatry, University of Heidelberg, Vossstrasse 4, D 69115 Heidelberg, Germany
Trends Cogn Sci 14:441-7. 2010An important shift is taking place in social cognition research, away from a focus on the individual mind and toward embodied and participatory aspects of social understanding...For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion
Kevin N Ochsner
Department of Psychology, Columbia University, 369 Schermerhorn Hall, New York, NY 10027, USA
Neuroimage 23:483-99. 2004....Influence of cognitive control and mismatch on the N2 component of the ERP: a review
Jonathan R Folstein
Department of Psychology, University of Arizona, Tucson, Arizona, USA
Psychophysiology 45:152-70. 2008..We focus on the visual modality for which components with frontocentral and more posterior scalp distributions can be readily distinguished...Cognitive reserve
Yaakov Stern
Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, United States
Neuropsychologia 47:2015-28. 2009..It then focuses on methodologic issues that are important when attempting to elucidate the neural underpinnings of cognitive reserve using imaging studies, and reviews some of our group's work in order to demonstrate these issues...Be smart, exercise your heart: exercise effects on brain and cognition
Charles H Hillman
Charles H Hillman is at the Department of Kinesiology and Community Health, 213 Louise Freer Hall, 906 South Goodwin Avenue, University of Illinois, Urbana, Illinois 61801, USA
Nat Rev Neurosci 9:58-65. 2008..Human and non-human animal studies have shown that aerobic exercise can improve a number of aspects of cognition and performance...Large-scale brain networks in cognition: emerging methods and principles
Steven L Bressler
Center for Complex Systems and Brain Sciences, Department of Psychology, Florida Atlantic University, Boca Raton, FL, USA
Trends Cogn Sci 14:277-90. 2010An understanding of how the human brain produces cognition ultimately depends on knowledge of large-scale brain organization...Evidence for a frontoparietal control system revealed by intrinsic functional connectivity
Justin L Vincent
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
J Neurophysiol 100:3328-42. 2008..The frontoparietal control system is therefore anatomically positioned to integrate information from these two opposing brain systems...The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Jeremy K Seamans
Department of Physiology, MUSC, 173 Ashley Avenue, Suite 403, Charleston, SC 29425, USA
Prog Neurobiol 74:1-58. 2004..Based on these factors, a theory is proposed for DA's action in PFC. This theory suggests that DA acts to expand or contract the breadth of information held in working memory buffers in PFC networks...Uncertainty-based competition between prefrontal and dorsolateral striatal systems for behavioral control
Nathaniel D Daw
Gatsby Computational Neuroscience Unit, University College London, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
Nat Neurosci 8:1704-11. 2005..This provides a unifying account of a wealth of experimental evidence about the factors favoring dominance by either system...The free-energy principle: a unified brain theory?
Karl Friston
The Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London, WC1N 3BG, UK
Nat Rev Neurosci 11:127-38. 2010..This is the quantity that is optimized under the free-energy principle, which suggests that several global brain theories might be unified within a free-energy framework...Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies
Catherine J Stoodley
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Neuroimage 44:489-501. 2009..Prospective studies of multiple domains within single individuals are necessary to better elucidate neurobehavioral structure-function correlations in the cerebellar posterior lobe...Neuroimaging studies of working memory: a meta-analysis
Tor D Wager
University of Michigan, Ann Arbor, Michigan, USA
Cogn Affect Behav Neurosci 3:255-74. 2003..Finally, we consider a potential fourth executive function: selective attention to features of a stimulus to be stored in WM, which leads to increased probability of activating the medial prefrontal cortex (BA 32) in storage tasks...The structural basis of inter-individual differences in human behaviour and cognition
Ryota Kanai
The UCL Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queen Square, London WC1N 3AR, UK
Nat Rev Neurosci 12:231-42. 2011..We propose that inter-individual differences can be used as a source of information to link human behaviour and cognition to brain anatomy.The neural basis of economic decision-making in the Ultimatum Game
Alan G Sanfey
Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
Science 300:1755-8. 2003..Unfair offers elicited activity in brain areas related to both emotion (anterior insula) and cognition (dorsolateral prefrontal cortex)...Joint action: bodies and minds moving together
Natalie Sebanz
Rutgers, The State University of New Jersey, Psychology Department, Smith Hall, 101 Warren Street, Newark, NJ 07102, USA
Trends Cogn Sci 10:70-6. 2006..Several mechanisms are proposed that allow individuals to share representations, to predict actions, and to integrate predicted effects of own and others' actions...A unifying view of the basis of social cognition
Vittorio Gallese
Department of Neuroscience, Section of Physiology, University of Parma, Italy
Trends Cogn Sci 8:396-403. 2004..A similar mechanism, but involving the activation of viscero-motor centers, underlies the experiential understanding of the emotions of others...Relating introspective accuracy to individual differences in brain structure
Stephen M Fleming
Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N 3BG, UK
Science 329:1541-3. 2010..Our findings point to a focal neuroanatomical substrate for introspective ability, a substrate distinct from that supporting primary perception...Gaze cueing of attention: visual attention, social cognition, and individual differences
Alexandra Frischen
Macquarie Centre for Cognitive Science, Macquarie University, Sydney, NSW, Australia
Psychol Bull 133:694-724. 2007..The contribution of this paradigm has been significant and will likely continue to advance knowledge across diverse fields within psychology and neuroscience...Selective review of cognitive aging
Timothy A Salthouse
Department of Psychology, University of Virginia, Charlottesville, Virginia 22904 4400, USA
J Int Neuropsychol Soc 16:754-60. 2010..of cognitive functioning, and what methods can be used to identify causes of age-related influences on cognition. Although definitive answers are not yet possible, quite a bit of information relevant to the questions is now ..Anterior cingulate cortex, error detection, and the online monitoring of performance
C S Carter
Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Science 280:747-9. 1998..This suggests that the ACC detects conditions under which errors are likely to occur rather than errors themselves...Brain aging, cognition in youth and old age and vascular disease in the Lothian Birth Cohort 1936: rationale, design and methodology of the imaging protocol
Joanna M Wardlaw
Brain Research Imaging Centre, Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
Int J Stroke 6:547-59. 2011..However, the changes in brain structure that accompany normal aging, and the role they play in cognitive decline, remain to be fully elucidated...Cardiovascular fitness, cortical plasticity, and aging
Stanley J Colcombe
The Beckman Institute, and Neuroscience Program, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Proc Natl Acad Sci U S A 101:3316-21. 2004..These data suggest that increased cardiovascular fitness can affect improvements in the plasticity of the aging human brain, and may serve to reduce both biological and cognitive senescence in humans...The processing-speed theory of adult age differences in cognition
T A Salthouse
Georgia Institute of Technology, Atlanta 30332 0170, USA
Psychol Rev 103:403-28. 1996A theory is proposed to account for some of the age-related differences reported in measures of Type A or fluid cognition. The central hypothesis in the theory is that increased age in adulthood is associated with a decrease in the speed ..Six views of embodied cognition
Margaret Wilson
Department of Psychology, University of California, Santa Cruz, CA 95064, USA
Psychon Bull Rev 9:625-36. 2002The emerging viewpoint of embodied cognition holds that cognitive processes are deeply rooted in the body's interactions with the world...Brain systems mediating cognitive interference by emotional distraction
Florin Dolcos
Brain Imaging and Analysis Center, Duke University, Durham, North Carolina 27710, USA
J Neurosci 26:2072-9. 2006....A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study
Glenn E Smith
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Am Geriatr Soc 57:594-603. 2009..To investigate the efficacy of a novel brain plasticity-based computerized cognitive training program in older adults and to evaluate the effect on untrained measures of memory and attention and participant-reported outcomes...Changes in cortical dopamine D1 receptor binding associated with cognitive training
Fiona McNab
Neuropediatric Unit, Department of Woman and Child Health, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
Science 323:800-2. 2009Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission...Putting brain training to the test
Adrian M Owen
MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK
Nature 465:775-8. 2010..Although improvements were observed in every one of the cognitive tasks that were trained, no evidence was found for transfer effects to untrained tasks, even when those tasks were cognitively closely related...Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection
Martin Sarter
Department of Psychology, University of Michigan, 525 E University Ave, Ann Arbor, MI 48109 1109, USA
Brain Res Brain Res Rev 48:98-111. 2005....The role of default network deactivation in cognition and disease
Alan Anticevic
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Trends Cogn Sci 16:584-92. 2012..Collectively, this research highlights the functional relevance of DMN suppression for goal-directed cognition, possibly by reducing goal-irrelevant functions supported by the DMN (e.g...Social cognition and the brain: a meta-analysis
Frank Van Overwalle
Department of Psychology, Vrije Universiteit Brussel, Brussel, Belgium
Hum Brain Mapp 30:829-58. 2009This meta-analysis explores the location and function of brain areas involved in social cognition, or the capacity to understand people's behavioral intentions, social beliefs, and personality traits...Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial
Nicola T Lautenschlager
WA Centre for Health and Ageing, University of Western Australia, Melbourne, Australia
JAMA 300:1027-37. 2008..Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking...Individual differences in non-verbal number acuity correlate with maths achievement
Justin Halberda
Johns Hopkins University, Ames Hall, 3400 North Charles Street, Baltimore, Maryland 21218, USA
Nature 455:665-8. 2008..Further research will determine whether early differences in number sense acuity affect later maths learning, whether maths education enhances number sense acuity, and the extent to which tertiary factors can affect both...Guidelines for using human event-related potentials to study cognition: recording standards and publication criteria
T W Picton
Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
Psychophysiology 37:127-52. 2000..The data must then be analyzed and presented in a way that allows different studies to be compared readily. This paper presents guidelines for recording ERPs and criteria for publishing the results...From sensation to cognition
M M Mesulam
Department of Neurology, Northwestern University Medical School, Chicago 60611, USA
Brain 121:1013-52. 1998..extensive associative elaboration and attentional modulation as it becomes incorporated into the texture of cognition. This process occurs along a core synaptic hierarchy which includes the primary sensory, upstream unimodal, ..Effects of cognitive training interventions with older adults: a randomized controlled trial
Karlene Ball
Department of Psychology, University of Alabama at Birmingham, 35294 2100, USA
JAMA 288:2271-81. 2002..However, few studies have addressed whether improving cognitive functions might have short- or long-term effects on activities related to living independently...Brain white matter tract integrity as a neural foundation for general intelligence
L Penke
Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK
Mol Psychiatry 17:1026-30. 2012....Enhanced perceptual functioning in autism: an update, and eight principles of autistic perception
Laurent Mottron
Pervasive Developmental Disorders Specialized Clinic, Riviere des Prairies Hospital, and Fernand Seguin Research Center, University of Montreal, Canada
J Autism Dev Disord 36:27-43. 2006..The overfunctioning of brain regions typically involved in primary perceptual functions may explain the autistic perceptual endophenotype...Frames, biases, and rational decision-making in the human brain
Benedetto De Martino
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1 3AR, UK
Science 313:684-7. 2006..This finding highlights the importance of incorporating emotional processes within models of human choice and suggests how the brain may modulate the effect of these biasing influences to approximate rationality...Valid conjunction inference with the minimum statistic
Thomas Nichols
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
Neuroimage 25:653-60. 2005..This result holds even if the comparisons are not independent. We suggest that the revised test proposed here is the appropriate means for conjunction inference in neuroimaging...A critical look at the embodied cognition hypothesis and a new proposal for grounding conceptual content
Bradford Z Mahon
Cognitive Neuropsychology Laboratory, Harvard University, Cambridge, MA 02138, USA
J Physiol Paris 102:59-70. 2008..Such results have been interpreted as indicating that concepts, and important aspects of cognition more broadly, are embodied. That conclusion does not follow from the empirical evidence...Disruption of large-scale brain systems in advanced aging
Jessica R Andrews-Hanna
Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
Neuron 56:924-35. 2007..accompanied by disruptive alterations in the coordination of large-scale brain systems that support high-level cognition. In 93 adults aged 18 to 93, we demonstrate that aging is characterized by marked reductions in normally present ..The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond
Ian J Deary
Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
BMC Geriatr 7:28. 2007..A limitation of many studies is the lack of a sufficiently long period between cognitive assessments to examine determinants. Here, the aim is to examine influences on cognitive ageing between childhood and old age...Structural and functional brain development and its relation to cognitive development
B J Casey
Department of Psychiatry, The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, 525 East 68th Street, Box 171, New York, NY 10021, USA
Biol Psychol 54:241-57. 2000..It is clear that innovative methods like fMRI together with MRI-based morphometry and nonhuman primate studies will transform our current understanding of human brain development and its relation to behavioral development...Gait and cognition: a complementary approach to understanding brain function and the risk of falling
Manuel Montero-Odasso
Division of Geriatric Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada
J Am Geriatr Soc 60:2127-36. 2012..but increasing evidence from clinical practice, epidemiological studies, and clinical trials shows that gait and cognition are interrelated in older adults...Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis
Jacob Raber
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, 97239, USA
Radiat Res 162:39-47. 2004..The significant loss of proliferating SGZ cells and their progeny suggests a contributory role of reduced neurogenesis in the pathogenesis of radiation-induced cognitive impairments...Storage and executive processes in the frontal lobes
E E Smith
Department of Psychology, Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 1109, USA
Science 283:1657-61. 1999..Two of the fundamental executive processes are selective attention and task management. Both processes activate the anterior cingulate and dorsolateral prefrontal cortex...Prenatal undernutrition and cognitive function in late adulthood
Susanne R de Rooij
Department of Clinical Epidemiology Biostatistics and Bioinformatics, Academic Medical Center of the University of Amsterdam, 1100 DD, Amsterdam, The Netherlands
Proc Natl Acad Sci U S A 107:16881-6. 2010..We hypothesize that this decline may be an early manifestation of an accelerated cognitive aging process...Can cognitive processes be inferred from neuroimaging data?
Russell A Poldrack
Department of Psychology and Brain Research Institute, UCLA, Los Angeles, CA 90095 1563, USA
Trends Cogn Sci 10:59-63. 2006There is much interest currently in using functional neuroimaging techniques to understand better the nature of cognition. One particular practice that has become common is 'reverse inference', by which the engagement of a particular ..The human inferior parietal cortex: cytoarchitectonic parcellation and interindividual variability
Svenja Caspers
C and O Vogt Brain Research Institute, University of Dusseldorf, P O Box 10 10 07, 40001 Dusseldorf, Germany
Neuroimage 33:430-48. 2006..Furthermore, the map is registered in three dimensions and thereby provides a robust anatomical base for interpreting functional imaging studies...Does working memory training work? The promise and challenges of enhancing cognition by training working memory
Alexandra B Morrison
Department of Psychology, Temple University, 6th Floor Weiss Hall, Philadelphia, PA 19122, USA
Psychon Bull Rev 18:46-60. 2011..Given the established relationship between WM and higher cognition, these successful training studies have led to speculation that WM training may yield broad cognitive benefits...Modes and models of forebrain cholinergic neuromodulation of cognition
Michael E Hasselmo
Center for Memory and Brain, Department of Psychology, Boston University, Boston, MA 02215, USA
Neuropsychopharmacology 36:52-73. 2011..The available evidence and these models point to new principles governing the development of the next generation of cholinergic treatments for cognitive disorders...Uniquely human social cognition
Rebecca Saxe
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology 46 4019, 43 Vassar St, Cambridge MA, 02138, USA
Curr Opin Neurobiol 16:235-9. 2006Recent data identify distinct components of social cognition associated with five brain regions. In posterior temporal cortex, the extrastriate body area is associated with perceiving the form of other human bodies...Understanding and sharing intentions: the origins of cultural cognition
Michael Tomasello
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Behav Brain Sci 28:675-91; discussion 691-735. 2005We propose that the crucial difference between human cognition and that of other species is the ability to participate with others in collaborative activities with shared goals and intentions: shared intentionality...Intellectual ability and cortical development in children and adolescents
P Shaw
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20182, USA
Nature 440:676-9. 2006..This study indicates that the neuroanatomical expression of intelligence in children is dynamic...Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry
Marcel Adam Just
Center for Cognitive Brain Imaging, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Cereb Cortex 17:951-61. 2007..These findings suggest that the neural basis of altered cognition in autism entails a lower degree of integration of information across certain cortical areas resulting from ..An application of prefrontal cortex function theory to cognitive aging
R L West
Department of Psychology, University of South Carolina, USA
Psychol Bull 120:272-92. 1996..I found the frontal lobe hypothesis to perform well, with the exception of an inability to account for age-related declines in item recall and recognition memory, possibly a result of age-related declines in medial temporal function...High gamma power is phase-locked to theta oscillations in human neocortex
R T Canolty
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
Science 313:1626-8. 2006..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...The electronic-cigarette: effects on desire to smoke, withdrawal symptoms and cognition
Lynne Dawkins
School of Psychology, University of East London, Water Lane, Stratford, London, England, United Kingdom
Addict Behav 37:970-3. 2012..Few studies have evaluated acute effects on craving and mood, and none have explored effects on cognition. This study aimed to explore the effects of the White Super e-cigarette on desire to smoke, nicotine withdrawal ..Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review
Erik G Willcutt
Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
Biol Psychiatry 57:1336-46. 2005..Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD...Diffusion tensor imaging of cerebral white matter integrity in cognitive aging
David J Madden
Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA
Biochim Biophys Acta 1822:386-400. 2012..tensor imaging (DTI) of white matter (WM) integrity and the implications for age-related differences in cognition. Neurobiological mechanisms defined from DTI analyses suggest that a primary dimension of age-related decline in ..Decoding the visual and subjective contents of the human brain
Yukiyasu Kamitani
ATR Computational Neuroscience Laboratories, 2 2 2 Hikaridai, Keihanna Science City, Kyoto 619 0288, Japan
Nat Neurosci 8:679-85. 2005..Our approach provides a framework for the readout of fine-tuned representations in the human brain and their subjective contents...The cortico-basal ganglia integrative network: the role of the thalamus
Suzanne N Haber
Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA suzanne
Brain Res Bull 78:69-74. 2009..the frontal cortical-basal ganglia-thalamic circuits that mediate motivation and emotional drive, planning and cognition for the development and expression of goal-directed behaviors...Breakfast habits, nutritional status, body weight, and academic performance in children and adolescents
Gail C Rampersaud
Food Science and Human Nutrition Department, Institute of Food and Agricultural Sciences, University of Florida, SW 23rd Drive, FETL Building 685, Gainesville, FL 32611 0720, USA
J Am Diet Assoc 105:743-60; quiz 761-2. 2005..We advocate consumption of a healthful breakfast on a daily basis consisting of a variety of foods, especially high-fiber and nutrient-rich whole grains, fruits, and dairy products...Perceptual symbol systems
L W Barsalou
Department of Psychology, Emory University, Atlanta, GA 30322, USA
Behav Brain Sci 22:577-609; discussion 610-60. 1999..Implications for cognition, neuroscience, evolution, development, and artificial intelligence are explored.The neural basis of inhibition in cognitive control
Adam R Aron
Department of Psychology, University of California, San Diego, La Jolla, CA 92093, USA
Neuroscientist 13:214-28. 2007..This article examines the role that neuroscience can play when examining whether the psychological concept of active inhibition can be meaningfully applied in cognitive control research...A neuropsychological theory of positive affect and its influence on cognition
F G Ashby
Department of Psychology, University of California, Santa Barbara 93106, USA
Psychol Rev 106:529-50. 1999..For example, the theory assumes that creative problem solving is improved, in part, because increased dopamine release in the anterior cingulate improves cognitive flexibility and facilitates the selection of cognitive perspective...Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study
Henry W Mahncke
Posit Science Corporation, 225 Bush Street, San Francisco, CA 94104, USA
Proc Natl Acad Sci U S A 103:12523-8. 2006Normal aging is associated with progressive functional losses in perception, cognition, and memory...Amyloid deposition is associated with impaired default network function in older persons without dementia
Reisa A Sperling
Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neuron 63:178-88. 2009....The role of the right temporoparietal junction in social interaction: how low-level computational processes contribute to meta-cognition
Jean Decety
Department of Psychology, and Center for Cognitive and Social Neuroscience, The University of Chicago, Chicago, IL 60637, USA
Neuroscientist 13:580-93. 2007..cortex, at the junction with the posterior temporal cortex, plays a critical role in various aspects of social cognition such as theory of mind and empathy...Dual-processing accounts of reasoning, judgment, and social cognition
Jonathan St B T Evans
Center for Thinking and Language, School of Psychology, University of Plymouth, Plymouth PL4 8AA, United Kingdom, USA
Annu Rev Psychol 59:255-78. 2008This article reviews a diverse set of proposals for dual processing in higher cognition within largely disconnected literatures in cognitive and social psychology...Anterior prefrontal function and the limits of human decision-making
Etienne Koechlin
Institut National de la Sante et de la Recherche Medicale, Departement d Etudes Cognitives, Ecole Normale Superieure, Universite Pierre et Marie Curie, 9, quai Saint Bernard, 75005 Paris, France
Science 318:594-8. 2007....Long-term effects of cognitive training on everyday functional outcomes in older adults
Sherry L Willis
Department of Human Development and Family Studies, Pennsylvania State University, State College, PA 16801
JAMA 296:2805-14. 2006..Cognitive training has been shown to improve cognitive abilities in older adults but the effects of cognitive training on everyday function have not been demonstrated...An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance
Gary Aston-Jones
Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Annu Rev Neurosci 28:403-50. 2005..We propose that these frontal areas produce the above patterns of LC activity to optimize utility on both short and long timescales...Neurocognitive mechanisms of cognitive control: the role of prefrontal cortex in action selection, response inhibition, performance monitoring, and reward-based learning
K Richard Ridderinkhof
Department of Psychology, University of Amsterdam, The Netherlands
Brain Cogn 56:129-40. 2004..Lateral and orbitofrontal divisions of prefrontal cortex are involved in subsequently implementing appropriate adjustments...The architecture of cognitive control in the human prefrontal cortex
Etienne Koechlin
Institut National de la Sante et de Recherche Medicale, Universite Pierre et Marie Curie, 9, quai St Bernard, 75005 Paris, France
Science 302:1181-5. 2003..The results support an unified modular model of cognitive control that describes the overall functional organization of the human lateral PFC and has basic methodological and theoretical implications...The locus coeruleus and noradrenergic modulation of cognition
Susan J Sara
CNRS UMR 7152, College de France, Paris 75005, France
Nat Rev Neurosci 10:211-23. 2009....Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
Paul A Adlard
Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
Neuron 59:43-55. 2008..The speed of recovery of the animals underscores the acutely reversible nature of the cognitive deficits associated with transgenic models of AD...Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition
R Nathan Spreng
Department of Psychology, Harvard University, Cambridge MA 02138, USA
Neuroimage 53:303-17. 2010..Consequently, many assume that default network activity is suppressed during goal-directed cognition. We challenge this assumption in an fMRI study of planning...Genetic foundations of human intelligence
Ian J Deary
Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland, UK
Hum Genet 126:215-32. 2009..Here, we describe the human intelligence phenotype, summarise the evidence for its heritability, provide an overview of and comment on molecular genetic studies, and comment on future progress in the field...Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion
Christopher Barkus
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
Eur J Pharmacol 626:49-56. 2010..Wied had a fundamental interest in the brain and behaviour, with a particular interest in the interface between cognition and emotion, and how impairments at this interface could underlie human psychopathology...Value computations in ventral medial prefrontal cortex during charitable decision making incorporate input from regions involved in social cognition
Todd A Hare
Computation and Neural Systems and Humanities and Social Science Divisions, California Institute of Technology, Pasadena, California 91125 7700, USA
J Neurosci 30:583-90. 2010..functional connectivity analyses indicated that the value signal in VMPFC might integrate inputs from networks, including the anterior insula and posterior superior temporal cortex, that are thought to be involved in social cognition.
Research Grants
- Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical IllnessEva Szigethy; Fiscal Year: 2009..abstract_text> ..
- Statin modulation of immunotherapy for Alzheimer diseaseJun Tan; Fiscal Year: 2012..anti-AD strategy, vaccination with the A( peptide, also reduces A( deposition in AD transgenic mice and improves cognition. Two major hypotheses regarding the actions of A( immunotherapy are the facilitation of microglial phagocytosis ..
- Physiology of Hypothalamic Neurosteroidal ProgesteronePaul E Micevych; Fiscal Year: 2013..synthesized de novo in the brain, have been implicated in functions ranging from stress, depression, anxiety, to cognition. One neurosteroid is progesterone, a classic sex hormone involved in the regulation of reproduction...
- Mechanism of action of omega-3 fatty acids in brain injuryCHARLES NICHOLAS SERHAN; Fiscal Year: 2010..particularly), are uniquely concentrated in the central nervous system and are involved in neuroprotection, cognition, and other brain and retinal functions...
- Regulation of AKAP79 Postsynaptic Membrane TargetingMARK L DELL'ACQUA; Fiscal Year: 2012..and glutamate receptor function are believed to be relevant for mechanisms of altered synaptic plasticity and cognition in neurological disorders such as Alzheimer's and epilepsy and mental health disorders such as Down ..
- Adenosine and the Basal Forebrain in the Control of Behavioral StateRobert E Strecker; Fiscal Year: 2012..for as little as 2 h for several days can impair cardiovascular, immune, and endocrine functions, as well as cognition and daytime vigilance...
- Glutamate receptor recruitment to new synapses in vivoPHILIP ERIC WASHBOURNE; Fiscal Year: 2013..formation of appropriate synapses is crucial for establishment of neuronal circuits that underlie behavior and cognition. Minor irregularities during synapse formation can lead to developmental disorders such as autism, mental ..
- Efficacy of GABAA a5 receptor inverse agonists in learning impaired ratsEARL MICHAEL GIBBS; Fiscal Year: 2010..This necessitates the development of new, better acting and safer medications for enhancing cognition. In this SBIR Phase I project, PhysioGenix will determine the efficacy, pharmacokinetics (PK), maximum tolerated ..
- Mechanisms of Heme Transport in MacrophagesCARINE CARINE WHITE; Fiscal Year: 2012..Perinatal iron deficiency negatively impacts intelligence and cognition in children. Heme is the most bioavailable form of iron for human consumption...
- Transplatin: A Novel Agent to Mitigate Cisplatin ToxicityVickram Ramkumar; Fiscal Year: 2013..Loss of hearing at this developmental stage hampers speech, cognition and social development. Thus, there is an urgent need to develop effective treatments to ameliorate ototoxicity...
- Neuroimaging Assessments of Brain Integrity in Aging MiceAi Ling Lin; Fiscal Year: 2013..CMRO2, CBF, CMRGlc, total ATP concentration;and, thus preserved brain structure, functional connectivity, and cognition during aging...
- The Role of Astrocytes in Cortical Interneuron DevelopmentKAREN MULLER SMITH; Fiscal Year: 2013..rhythms so that excitatory neurons can fire in synchrony- properties deemed to be critical for their function in cognition and behavioral control...
- Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat BrainJENNE MITCHELL WESTBERRY; Fiscal Year: 2012..These insights could lead to development of therapeutics that result in improved cognition in the postmenopausal woman by potentially preventing changes in ER2 gene expression...
- Neuroprotection by IFN-beta in AIDSMarcus Kaul; Fiscal Year: 2013..IFN? can inhibit HIV/gp120 from inducing neuronal damage and impairing neurogenesis and compromising memory and cognition by a unique combination of mechanisms, comprising the induction of neuroprotective ?-chemokines and neurotrophic ..
- Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's DiseaseCRAIG STEPHEN ATWOOD; Fiscal Year: 2013..healthy postmenopausal women taking 17[unreadable]-estradiol (E2), the major female estrogen, 2) improvements in cognition in subjects treated with physiologically relevant sex steroids: women treated with E2 (3 controlled/1 ..
- A Computational Framework for Mapping Long Range Genetic CircuitsTolga Tasdizen; Fiscal Year: 2010..The long range links to other cortical or subcortical structures involved in regulation of emotion or cognition, particularly at the scale needed for primate systems cannot yet be visualized...
- Vascular and Skeletal Muscle Function in Gulf War Veterans IllnessScott Kinlay; Fiscal Year: 2013..criteria, which are based on statistical symptom cluster analysis resulting in three categories: fatigue, mood/ cognition, and musculoskeletal symptoms...
- KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATIONPALMER WILLIAM TAYLOR; Fiscal Year: 2013..proteins that affect the intensity and duration of acetylcholine action, a critical neurotransmitter affecting cognition in the CNS and peripheral autonomic and motor function...
- Design and Synthesis of Anxioselective AnxiolyticsJames M Cook; Fiscal Year: 2010..This is of special importance here in regard to cognition/amnesia and other processes mediated by the hippocampus...
- Dietary Cholesterol and Defects in Cholesterol SynthesisROBERT DAVID STEINER; Fiscal Year: 2013..Treatment efficacy will be judged primarily on changes in cognition and behavior (clinical) but also on surrogate biochemical and other measures (i.e...
- Interacting Impact of Adrenal and Ovarian Aging on the CNSHenryk F Urbanski; Fiscal Year: 2011..the perimenopausal decline in estradiol, and thereby negatively impacts central physiological processes such as cognition, learning, and attention, and leads to perturbation of the circadian sleep-wake cycle...
- Intravenous Protein Therapy for Myotonic Dystrophy Type 1Richard Weisbart; Fiscal Year: 2010..muscle wasting and myotonia, insulin resistance, testicular atrophy, cutaneous tumors cardiac arrhythmia and cognition defects (4- 8)...
- Connexins in Neuronal and Glial Gap Junctions in the Central Nervous SystemJohn E Rash; Fiscal Year: 2012..neuronal oscillatory synchronizations that are thought to underlie consciousness, arousal from sleep, cognition, associative binding for learning and memory, and fine motor control, and which become pathologically altered in ..
- Mechanism of CREB dysregulation in Alzheimer brainSubbiah Pugazhenthi; Fiscal Year: 2013..Cyclic AMP response element binding protein (CREB), a nuclear transcription factor, enhances cognition, memory formation and neuronal survival. CREB is known to be downregulated in the AD brain...
- Low level exposure to PBDEs: testing the hormetic and epigenetic hypothesesLucio G Costa; Fiscal Year: 2013..periods causes long-lasting behavioral abnormalities, particularly in the domains of motor activity and cognition. Limited evidence is also suggestive of possible developmental adverse effects in humans from PBDE exposure...
- Predictors of sleep-dependent Memory Consolidation in Obstructive Sleep ApneaIna E Djonlagic; Fiscal Year: 2013..an Associate Professor of Psychiatry at Harvard Medical School and Director of the Center for Sleep and Cognition at Beth Israel Deaconess Medical Center. Dr...
- Air Toxics, Neighborhood Environment and Risk of Oral CleftsPhilip J Lupo; Fiscal Year: 2013..Children with CL[unreadable]P suffer deficits in speech, hearing and cognition and have higher morbidity and mortality throughout life compared to their unaffected contemporaries...
- Neuroendocrine Contribution to Behavior &Cognition in the Female LifespanC NEILL NEILL EPPERSON; Fiscal Year: 2013..by which sex hormones and neurosteroids interact with neurotransmitters to modulate behavior, mood, and cognition in women...
- Pathogenesis of cognitive/neurologic deficits in central nervous system malariaChandy C John; Fiscal Year: 2012..However, the effects of CM on cognition in younger children have not been prospectively characterized, and the underlying question of what leads to ..
- Genomics of RNA Editing: Identification and RegulationJin Billy Li; Fiscal Year: 2013..suicide, glioma, and cancers, and may have contributed to the evolutionary development of human neurobiology and cognition. While numerous RNA editing sites have been identified to date, we are still far from possessing a complete list ..
- Epigenetics and choline: mediation of fetal alcohol effects in a rat modelCarol L Cheatham; Fiscal Year: 2013..provided by applicant): The proposed training is designed to provide the candidate with a background in animal cognition and testing as well as training in molecular mechanisms of development...
- Presynaptic Mechanisms Regulating the Dopamine TransporterJAMES A HARDAWAY; Fiscal Year: 2013..In humans, DA signaling modulates arousal, cognition, reward, and motor function...
- Modeling schizophrenia gamma deficits using cell-specific RNAi knockdown of GAD67RITCHIE EDWARD BROWN; Fiscal Year: 2012..construct validity which can be used to develop new therapeutic approaches to improve gamma oscillations and cognition;and (iii) Determine whether downregulation of GAD67 expression can cause cortical circuitry deficits typical of ..
- SIRT1 as a regulator of health and lifespan of mammalsDavid A Sinclair; Fiscal Year: 2013..of aging in highly energetic organs and tissues can be reversed by assessing metabolism, motor function, and cognition. Recent evidence from C...
- The Greatest Generation: The NAS-NRC WWII Twin Registry as a Scientific ResourceMargaret Gatz; Fiscal Year: 2012..Selected twins have also participated in sub-studies where data include screening for cognition and various complex diseases, in-person medical examinations and resulting diagnoses, and genotyping...
- Epigenetic Changes in the Glucocorticoid Receptor Gene Due to Arsenic ExposureAndrea M Allan; Fiscal Year: 2013..The GRs are particularly concentrated in areas of central importance for cognition (hippocampus, amygdala and frontal cortex)...
- Frontal Lobe Injury and Executive Control of Cognition and EmotionDiane Swick; Fiscal Year: 2013..Since these conditions can result in tremendous losses of productivity, the development of more sensitive assessments of brain health can assist in tailoring rehabilitation efforts to the needs of individual patients. ..
- Development and Regulation of Cholinergic SynapsesAndres Villu Maricq; Fiscal Year: 2013..Cholinergic neurotransmission is implicated in nicotine addiction, memory and cognition. Perturbations in a7 AChR regulation and function are thought to contribute to a broad spectrum of neuronal ..
- Dopaminergic Mechanisms of Cytokine-Induced Behavioral ChangeAndrew H Miller; Fiscal Year: 2012..a pivotal role in regulating multiple behaviors including mood, motivation/reward, motor activity, sleep and cognition. To explore effects of cytokines on DA and the basal ganglia, we have studied patients receiving treatment with ..
- Human VGF Polymorphisms and DepressionStephen R Salton; Fiscal Year: 2010..mouse models, determining whether carriers of this polymorphism could be predisposed to depression and impaired cognition, much as those with aberrant BDNF expression and/or signaling are at risk for memory and behavioral disorders...
- Synaptic autoimmunity in disorders of memory, behavior, cognition and psychosisJosep Dalmau; Fiscal Year: 2010..the characterization of autoimmune responses to synaptic proteins that result in disorders of behavior, memory, cognition and psychosis...
- Epidemiology of Retinopathy and other Complications in Long Term Type 1 DiabetesMichael Y Tsai; Fiscal Year: 2013..acuity, carotid artery ultrasound, electrocardiogram, measurement of skin intrinsic fluorescence, tests of cognition, and measurement of serum (e.g...
- Freeze-Dried Blueberries: Prevention and Rehabilitation Strategies in MSSusan O McGuire; Fiscal Year: 2011..Some also improve cognition and depression in animals, symptoms that are troublesome for the MS patient...
- Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential DrugsHeike Wulff; Fiscal Year: 2012..validate KCa2 channels as novel pharmacological targets for the treatment of epilepsy and would further provide the scientific community with tool compounds to study the role of KCa2 channels in ataxia, neuropathic pain and cognition.
- Neuroprotective strategies in seizure-induced damageJANA VELISKOVA; Fiscal Year: 2011..of gender-specific expression of such processes as depression/anxiety, stress processing, memory, and cognition.2-Estradiol has neuroprotective effects in several neurodegenerative diseases including the seizure-induced ..
- BDNF-Estrogen Interactions with Perimenopausal Mood and CognitionElizabeth M Waters; Fiscal Year: 2012..These studies will provide information on the interaction of estrogen and BDNF in affective disorders and could lead to improved hormone replacement therapies to alleviate menopausal symptoms. ..
- Cerebrovascular Disease and its Consequences in the Strong Study CohortDedra S Buchwald; Fiscal Year: 2013..were not, however, benign accompaniments of aging as they were associated with impaired motor function and cognition, depression, and a striking increase in the risk of subsequent stroke and death...
- Noncoding RNAs as epigenomic modulators in Alzheimer's DiseaseCLAES ROBERT WAHLESTEDT; Fiscal Year: 2010..disease is a devastating age-related neurodegenerative disorder characterized by progressive impairment of cognition and short-term memory loss...
- Regulation of 22q11 Genes in Embroyonic and Adult ForebrainAnthony S LaMantia; Fiscal Year: 2013..Syndrome) occurs in approximately 1/3000 live births and confers increased vulnerability for language and social cognition deficits, attention deficit/hyperactivity disorder, autism, mood disorders, and schizophrenia...
- The role of diet-induced obesity in cognitive impairmentCATRINA SIMS ROBINSON; Fiscal Year: 2013..have demonstrated that improving insulin signaling in the central nervous system (CNS) has a positive impact on cognition;however, obese individuals are excluded from such studies...
- Outcomes and Predictors in Mild Cognitive ImpairmentMary Ganguli; Fiscal Year: 2012..Apo A1, ApoB, homocysteine, C-Reactive Protein, and cystatin) from subgroups of participants with normal cognition and with subtypes of MCI...
- Adolescent brains, nicotine and endogenous prototoxinsRae Nishi; Fiscal Year: 2010..Grant is a multidisciplinary approach that involves investigators from the fields of animal behavior, human cognition, genetic epidemiology, and molecular cell biology to test the validity of the following model: that the enhanced ..
- DETERMINATION OF NEURONAL FATES IN VISUAL CORTEXSusan K McConnell; Fiscal Year: 2013..Defects in the formation and elaboration of cortical circuits have fundamental implications for vision, cognition, and mental health, since defects in the migration and connectivity of cortical neurons are associated with a ..
- miR132 regulation of neuronal plasticity, learning, and memoryKATELIN L F HANSEN; Fiscal Year: 2013..Thus, the functional role of miRNAs in nervous system physiology and cognition merits close examination...
- CRCNS: Theory and experiment of neural circuit mapping by DNA sequencingAnthony M Zador; Fiscal Year: 2013..A wide range of brain functions, including sensory perception, learning, memory, decision making, cognition, reasoning, and communication, is therefore related to the details of this neuronal connectivity...
- Molecular-Genetic Dissection of Basal Forebrain Circuitry Regulating ArousalPATRICK MICHAEL FULLER; Fiscal Year: 2013..complex brain region that is implicated in a wide range of higher-level neurobiological processes including, cognition, learning, memory and attention, virtually all of which operate on a basis of wakefulness...
- Nicotinic receptor stimulation and epigenetic regulation of GABAergic function.Alessandro Guidotti; Fiscal Year: 2013..antagonist drugs (typical or atypical neuroleptics) has an antipsychotic effect, but negative symptoms and cognition are not significantly improved...
- Endocannabinoid DiscriminationJenny L Wiley; Fiscal Year: 2013..g., brain reward, appetite regulation, cognition)...
- Inhibition of HIV-Induced Synaptodentritic DamageVal S Goodfellow; Fiscal Year: 2013..Damage to synaptic architecture is the key pathological process of HAND in cognition and memory impairment...
- Endocannabinoid Intracellular TransportersDale G Deutsch; Fiscal Year: 2010..as a new drug target drug target may lead to treatment for addiction, mood disorders, pain and inflammation, cognition, and appetite regulation...
- Measuring Altered Social Behavior in Neurodegenerative DiseaseKatherine P Rankin; Fiscal Year: 2013..The specific aim of this project is to adapt existing measures of social cognition for reliable and valid use in neurodegenerative diseases...
- Hypothalamic autophagy and metabolic regulation in agingRajat Singh; Fiscal Year: 2013..through one of many adverse effects on cardio- and cerebrovascular health, locomotor activity, vision and cognition, as well as on the development of tumors...
- Long Term Outcomes in ICU Patients: Delirium & Apolipoprotein ESheila Alexander; Fiscal Year: 2009Delirium and Apolipoprotein Delirium, a disturbance is consciousness with inattention accompanied by a change in cognition or perceptual disturbances, is a common occurrence in hospitalized patients in and out of the ICU...
- Vitamin B12 and Folate in Relation to Cognition in the Framingham Offspring StudyJacob Selhub; Fiscal Year: 2010..Few previous studies of cognition investigated the interaction between vitamin B12 status and folate status, and most that looked at the main- ..
- Social Cognition and Functioning in Bipolar DisorderMichael F Green; Fiscal Year: 2010..An extensive literature in schizophrenia research has established that basic (non-social) cognition is a key determinant of functional outcome in schizophrenia and that social cognition acts as a mediator between ..
- Remediation of Working Memory in SchizophreniaTasha Nienow; Fiscal Year: 2009..The proposed intervention study is designed to enhance cognition and psychosocial functioning in patients...
- Young Development of a Novel PET Ligand for Detecting Oxytocin Receptors in BrainLarry J Young; Fiscal Year: 2012..provided by applicant): Oxytocin (OT) is a neuropeptide that has been implicated in the regulation of social cognition and social behavior both in animal models and in humans...
- Brain-Based Measures for Treatment Development of Impaired Cognition in SchizophrCameron S Carter; Fiscal Year: 2010..the past decade there has been a growing awareness of the disabling and treatment refractory effects of impaired cognition in schizophrenia, which results in performance deficits that are strongly and consistently related to poor ..
- Aging, Social Interdependence and Wisdom in the U.S. and JapanRichard E Nisbett; Fiscal Year: 2010..older people are more interdependent than younger people and (2) as a consequence, they become more holistic in cognition, and (3) in part as a result of more holistic thinking, they become wiser in some respects...
- ANDROGEN EFFECTS ON COGNITION IN TURNER SYNDROMEJudith Ross; Fiscal Year: 2007..a unique, sex hormone-deficient model in which to study the biological effects of androgen treatment on cognition and behavior in females...
- Metal and Organochlorines Exposure: Impact on Adolescent Behavior and CognitionSusan A Korrick; Fiscal Year: 2010..of early life exposure to neurotoxic metal mixtures, and their interactions, with early adolescent behavior and cognition. The metals to be studied are prenatal manganese (Mn), methylmercury (MeHg), arsenic (As), lead (Pb) and ..
- A Study of Narrative as the Cognitivie Process Underlying Diagnostic ReasoningCURTIS SCOTT SMITH; Fiscal Year: 2010..Studies in cognitive science and social psychology suggest that narrative cognition integrates these two processes. The role of narrative cognition in medical diagnosis is not well understood...
- COGNITION, STEROIDS AND IMAGING IN CUSHINGS DISEASEMONICA STARKMAN; Fiscal Year: 2001..Patients with CD exhibit hypercortisolemia and develop disturbances in mood, sleep, libido, and cognition. The investigator's hypothesis is that steroid elevations in these various conditions have important neuroactive ..
- Cognitive Decline and Dementia: Life Experiences and the Brain Histone EpigenomeDavid A Bennett; Fiscal Year: 2010..cerebrovascular disease, and Lewy body disease, these conditions only account for about 20% of the variance of cognition in older persons...
- COGNITION AND PANICRichard McNally; Fiscal Year: 1991..Unfortunately, most cognitive research has relied solely on patient self-report as the sole measure of cognition. Investigators have yet to apply the experimental paradigms of cognitive psychology to study cognition and panic...
- SOCIAL-COGNITIVE FUNCTIONING IN AGING AND DEMENTIAAllyson Washburn; Fiscal Year: 1999..proposed pilot work is preliminary to a longitudinal study of the relationships among social behavior, social cognition, and general cognitive status in dementia patients and in a group of controls matched for age, gender, and ..
- LIFE-SPAN DEVELOPMENT--MECHANISMS OF EVERYDAY COGNITIONHAYNE REESE; Fiscal Year: 1990..provide a unique integration of theoretical perspectives, methodology, and data on the mechanisms of everyday cognition across the life-span...