schizotypal personality disorder

Summary

Summary: A personality disorder in which there are oddities of thought (magical thinking, paranoid ideation, suspiciousness), perception (illusions, depersonalization), speech (digressive, vague, overelaborate), and behavior (inappropriate affect in social interactions, frequently social isolation) that are not severe enough to characterize schizophrenia.

Top Publications

  1. ncbi Clinical characteristics of first-admitted patients with ICD-10 schizotypal disorder
    Peter Handest
    University Department of Psychiatry, Hvidovre Hospital, Brøndby stervej 160, 2605 Brønby, Denmark
    Br J Psychiatry Suppl 48:s49-54. 2005
  2. ncbi Anxiety and depression symptoms in psychometrically identified schizotypy
    Kathryn E Lewandowski
    University of North Carolina at Greensboro, Department of Psychology, 296 Eberhart Building, Greensboro, NC 27402, USA
    Schizophr Res 83:225-35. 2006
  3. ncbi Schizotypal personality: neurodevelopmental and psychosocial trajectories
    Adrian Raine
    Department of Psychology and Neuroscience Program, University of Southern California, Los Angeles, California 90089 1061, USA
    Annu Rev Clin Psychol 2:291-326. 2006
  4. ncbi A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population
    Xiaohong Ma
    Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China
    Psychiatry Res 153:7-15. 2007
  5. doi A follow-up MRI study of the superior temporal subregions in schizotypal disorder and first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 119:65-74. 2010
  6. ncbi Reduced Kamin blocking in non paranoid schizophrenia: associations with schizotypy
    P M Moran
    School of Psychology, University of Leicester, University Road, Leicester LE1 7RH, UK
    J Psychiatr Res 37:155-63. 2003
  7. pmc Fronto-temporal disconnectivity in schizotypal personality disorder: a diffusion tensor imaging study
    Motoaki Nakamura
    Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, MA 02301, USA
    Biol Psychiatry 58:468-78. 2005
  8. pmc Emotion processing in persons at risk for schizophrenia
    Laura K Phillips
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Schizophr Bull 34:888-903. 2008
  9. ncbi Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity allele
    Franck Schurhoff
    Département Hospitalo Universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor, 40 rue Mesly, Creteil, France
    Am J Med Genet B Neuropsychiatr Genet 144:64-8. 2007
  10. ncbi Sustained attention deficits in relation to psychometrically identified schizotypy: evaluating a potential endophenotypic marker
    Diane C Gooding
    University of Wisconsin Madison, Department of Psychology, Madison, WI 53706, USA
    Schizophr Res 82:27-37. 2006

Detail Information

Publications243 found, 100 shown here

  1. ncbi Clinical characteristics of first-admitted patients with ICD-10 schizotypal disorder
    Peter Handest
    University Department of Psychiatry, Hvidovre Hospital, Brøndby stervej 160, 2605 Brønby, Denmark
    Br J Psychiatry Suppl 48:s49-54. 2005
    ..The clinical picture of schizotypal disorders is rarely comprehensively described...
  2. ncbi Anxiety and depression symptoms in psychometrically identified schizotypy
    Kathryn E Lewandowski
    University of North Carolina at Greensboro, Department of Psychology, 296 Eberhart Building, Greensboro, NC 27402, USA
    Schizophr Res 83:225-35. 2006
    ....
  3. ncbi Schizotypal personality: neurodevelopmental and psychosocial trajectories
    Adrian Raine
    Department of Psychology and Neuroscience Program, University of Southern California, Los Angeles, California 90089 1061, USA
    Annu Rev Clin Psychol 2:291-326. 2006
    ....
  4. ncbi A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population
    Xiaohong Ma
    Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China
    Psychiatry Res 153:7-15. 2007
    ..Molecular Psychiatry 7, 706-711]. We conclude that SNP Val158Met (rs4680) in the COMT gene may be associated with some schizotypal traits in male subjects, but our results are not conclusive...
  5. doi A follow-up MRI study of the superior temporal subregions in schizotypal disorder and first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 119:65-74. 2010
    ....
  6. ncbi Reduced Kamin blocking in non paranoid schizophrenia: associations with schizotypy
    P M Moran
    School of Psychology, University of Leicester, University Road, Leicester LE1 7RH, UK
    J Psychiatr Res 37:155-63. 2003
    ....
  7. pmc Fronto-temporal disconnectivity in schizotypal personality disorder: a diffusion tensor imaging study
    Motoaki Nakamura
    Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, MA 02301, USA
    Biol Psychiatry 58:468-78. 2005
    ..Here, we investigate these two bundles in unmedicated subjects with schizotypal personality disorder (SPD).
  8. pmc Emotion processing in persons at risk for schizophrenia
    Laura K Phillips
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Schizophr Bull 34:888-903. 2008
    ..The most robust findings in at-risk groups are in the areas of reduced emotion perception, self-reported anhedonia, and increased negative affect. We conclude with an agenda for future research...
  9. ncbi Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity allele
    Franck Schurhoff
    Département Hospitalo Universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor, 40 rue Mesly, Creteil, France
    Am J Med Genet B Neuropsychiatr Genet 144:64-8. 2007
    ....
  10. ncbi Sustained attention deficits in relation to psychometrically identified schizotypy: evaluating a potential endophenotypic marker
    Diane C Gooding
    University of Wisconsin Madison, Department of Psychology, Madison, WI 53706, USA
    Schizophr Res 82:27-37. 2006
    ..The findings add to the converging evidence indicating that sustained attention deficits are a potential endophenotypic indicator of a schizophrenia diathesis...
  11. ncbi Saccadic eye movements, schizotypy, and the role of neuroticism
    Ulrich Ettinger
    Department of Psychology, McGill University, Stewart Biological Sciences Building, 1205 Dr Penfield Ave, Montreal, Que, Canada H3A 1B1
    Biol Psychol 68:61-78. 2005
    ..We conclude that saccadic performance patterns in schizotypy are not due to negative emotionality or general psychopathology, but specific to schizophrenia spectrum signs and symptoms...
  12. ncbi Temporal lobe volume determined by magnetic resonance imaging in schizotypal personality disorder and schizophrenia
    J E Downhill
    Department of Psychiatry, Neuroscience PET Lab, Box 1505, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
    Schizophr Res 48:187-99. 2001
    ..gyrus and the corpus callosum were measured on magnetic resonance images from 13 patients with schizotypal personality disorder (SPD), 27 patients with schizophrenia, and 31 age- and sex-matched controls...
  13. ncbi Emotional correlates of the different dimensions of schizotypal personality disorder
    Howard Berenbaum
    Department of Psychology, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    J Abnorm Psychol 115:359-68. 2006
    Two studies explored which different dimensions of schizotypal personality disorder (SPD) were associated with negative affect, attention to emotions, clarity of emotions, and emotional intensity/instability...
  14. ncbi Schizotypy facets, cognitive control, and emotion
    John G Kerns
    Department of Psychological Sciences, University of Missouri Columbia, 65211, USA
    J Abnorm Psychol 115:418-27. 2006
    ....
  15. pmc Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk?
    Alison R Yung
    ORYGEN Research Centre, 35 Poplar Road, Parkville 3052, Victoria, Australia
    Schizophr Bull 33:673-81. 2007
    ..Patients presenting to them need help. It may be that we need to aim to prevent a range of target syndromes...
  16. pmc Looking at the schizophrenia spectrum through the prism of self-disorders: an empirical study
    Andrea Raballo
    Danish National Research Foundation Center for Subjectivity Research, University of Copenhagen, Copenhagen S, Denmark
    Schizophr Bull 37:344-51. 2011
    ..Manual of Mental Disorders (Third Edition Revised) main diagnosis: schizophrenia, (n = 29), schizotypal personality disorder (n = 61), other mental illness not belonging to the schizophrenia spectrum (n = 112), and no mental ..
  17. ncbi Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Brain 128:2109-22. 2005
    ....
  18. ncbi Social anhedonia as a predictor of the development of schizophrenia-spectrum disorders
    T R Kwapil
    Department of Psychology, University of Wisconsin, Madison, USA
    J Abnorm Psychol 107:558-65. 1998
    ..Thus, the SocAnh Scale, unlike the Perceptual Aberration and Magical Ideation Scales, appears to identify individuals at specific risk for future development of schizophrenia-spectrum disorders...
  19. ncbi Hedonic capacity and schizotypy revisited: a taxometric analysis of social anhedonia
    J J Blanchard
    Department of Psychology, University of New Mexico, USA
    J Abnorm Psychol 109:87-95. 2000
    ..10. These data are interpreted in the context of other findings suggesting that social anhedonia is an indicator of schizotypy...
  20. ncbi Perceptual aberrations impair mental own-body transformations
    C Mohr
    Department of Experimental Psychology, University of Bristol, Bristol, United Kingdom
    Behav Neurosci 120:528-34. 2006
    ....
  21. ncbi Schizotypy in community samples: the three-factor structure and correlation with sustained attention
    W J Chen
    Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei
    J Abnorm Psychol 106:649-54. 1997
    ..The PAS differed from the Cognitive-Perceptual factor in its consistent association with poorer attention in both samples. These have important implications for the scales in the early detection of the schizotypy in various cultures...
  22. ncbi Magnetic resonance imaging of the thalamic mediodorsal nucleus and pulvinar in schizophrenia and schizotypal personality disorder
    W Byne
    Mount Sinai School of Medicine, New York, NY, USA
    Arch Gen Psychiatry 58:133-40. 2001
    ..Because frontal and temporal lobe volumes are diminished in schizophrenia, volume loss could characterize their primary thalamic relay nuclei (mediodorsal nucleus [MDN] and pulvinar)...
  23. doi Objective measures of prospective memory do not correlate with subjective complaints in schizophrenia
    Raymond C K Chan
    Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    Schizophr Res 103:229-39. 2008
    ..poorer performance in all domains of memory function except visual memory than individuals with schizotypal personality disorder and healthy controls...
  24. ncbi Gray matter features of schizotypal disorder patients exhibiting the schizophrenia-related code types of the Minnesota Multiphasic Personality Inventory
    E Yoneyama
    Department of Neuropsychiatry, School of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Acta Psychiatr Scand 108:333-40. 2003
    ..We hypothesized that schizotypal disorder (STD) patients with such schizophrenia-related code types have the morphological brain abnormalities associated with schizophrenia...
  25. ncbi Schizotypal personality disorder inside and outside the schizophrenic spectrum
    Svenn Torgersen
    Department of Psychology, Center for Research in Clinical Psychology, Oslo University, PO Box 1039, Blindern, N 0315 Oslo, Norway
    Schizophr Res 54:33-8. 2002
    The concept of schizotypal personality disorder has been heavily discussed since its introduction into the official classification of mental disorders in DSM-III...
  26. pmc Clinical, cognitive, and social characteristics of a sample of neuroleptic-naive persons with schizotypal personality disorder
    Chandlee C Dickey
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Psychiatry 116A, 940 Belmont St, Brockton, MA 02401, USA
    Schizophr Res 78:297-308. 2005
    b>Schizotypal personality disorder (SPD) shares with schizophrenia many biological features, yet little is known about the clinical characteristics of persons diagnosed with this disorder...
  27. ncbi Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorder
    Min Seong Koo
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Arch Gen Psychiatry 63:1090-100. 2006
    Structural brain abnormalities, including larger cerebrospinal fluid (CSF) volumes, have been observed in men diagnosed as having schizotypal personality disorder (SPD).
  28. ncbi Cannabis use is associated with schizotypy and attentional disinhibition
    P D Skosnik
    Department of Psychology, Northwestern University, Evanston, IL 60208, USA
    Schizophr Res 48:83-92. 2001
    ..These results suggest that cannabis use can mimic attentional deficits seen in acute schizophrenia and is associated with schizotypal personality, thus setting the stage for a possible cannabinoid model of SZ...
  29. pmc Factors in sensory processing of prosody in schizotypal personality disorder: an fMRI experiment
    Chandlee C Dickey
    Serious Mental Illness Program, VA Boston Healthcare System, Psychiatry 116A 7, 940 Belmont St, Brockton, MA 02301, United States
    Schizophr Res 121:75-89. 2010
    ..To examine prosody along the schizophrenia spectrum, antipsychotic-naïve schizotypal personality disorder (SPD) subjects and healthy control subjects were compared...
  30. ncbi Topographic abnormalities of P3 in schizotypal personality disorder
    D F Salisbury
    Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, Boston, USA
    Biol Psychiatry 40:165-72. 1996
    ..Asymmetry of P3 amplitude, with left-sided deficit, may be associated with the schizophrenia diathesis, but overall P3 reductions may be more associated with chronic effects...
  31. pmc Auditory steady state response in the schizophrenia, first-degree relatives, and schizotypal personality disorder
    Olga Rass
    Department of Psychological and Brain Sciences, Indiana University, 1101 East 10th Street, Bloomington, IN 47405, USA
    Schizophr Res 136:143-9. 2012
    ..The sensitivity of the 40 Hz ASSR to schizophrenia spectrum phenotypes, such as schizotypal personality disorder (SPD), or to familial risk has been less well characterized...
  32. ncbi The effects of guanfacine on context processing abnormalities in schizotypal personality disorder
    Margaret M McClure
    VA VISN3 Mental Illness Research, Education, and Clinical Center, Bronx, New York 10468, USA
    Biol Psychiatry 61:1157-60. 2007
    The signature of impaired cognition in people with schizotypal personality disorder (SPD) may be centrally related to working memory impairments...
  33. pmc MRI abnormalities of the hippocampus and cavum septi pellucidi in females with schizotypal personality disorder
    Chandlee C Dickey
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA
    Schizophr Res 89:49-58. 2007
    This study examined MRI hippocampal volume and cavum septi pellucidi (CSP) in female subjects with schizotypal personality disorder (SPD) and comparison subjects.
  34. doi Emotion dysregulation and schizotypy
    Julie D Henry
    School of Psychology, University of New South Wales, Sydney, NSW 2052 Australia
    Psychiatry Res 166:116-24. 2009
    ..Implications for understanding blunted affect in schizophrenia and related disorders are discussed...
  35. ncbi Neurocognitive, behavioural and neurodevelopmental correlates of schizotypy clusters in adolescents from the general population
    Neus Barrantes-Vidal
    Departament de Psicologia de la Salut, Facultat de Psicologia, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Schizophr Res 61:293-302. 2003
    ..We aimed to establish clusters of normal adolescents based on schizotypy dimensions and compare them on neurocognitive, behavioural, and neurodevelopmental markers...
  36. ncbi Prefrontal structural and functional deficits in schizotypal personality disorder
    Adrian Raine
    Department of Psychology, University of Southern California, Los Angeles, CA 90089 1061, USA
    Schizophr Bull 28:501-13. 2002
    ....
  37. ncbi Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorder
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur Arch Psychiatry Clin Neurosci 252:268-77. 2002
    ..These results suggest that both schizotypal and schizophrenic subjects share, at least in part, the same cerebral asymmetry abnormalities...
  38. pmc Smaller left Heschl's gyrus volume in patients with schizotypal personality disorder
    Chandlee C Dickey
    Harvard Medical School, Clinical Neuroscience Division, Department of Psychiatry, VA Boston Healthcare System, Brockton, MA 02401, USA
    Am J Psychiatry 159:1521-7. 2002
    ..Magnetic resonance imaging (MRI) studies have shown smaller gray matter volume in patients with schizotypal personality disorder than in matched comparison subjects in the left superior temporal gyrus, an area important for ..
  39. doi Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene
    Yuka Yasuda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurosci Lett 495:216-20. 2011
    ..an increased risk not only for schizophrenia but also for schizophrenia spectrum disorders, such as schizotypal personality disorder. A single nucleotide polymorphism (SNP), rs1344706, in the Zinc Finger Protein 804A (ZNF804A) gene, ..
  40. pmc Heritability and longitudinal stability of schizotypal traits during adolescence
    Marissa Ericson
    Department of Psychology SGM 501, University of Southern California, Los Angeles, CA 90089 1061, USA
    Behav Genet 41:499-511. 2011
    ....
  41. pmc Cingulate and temporal lobe fractional anisotropy in schizotypal personality disorder
    Erin A Hazlett
    Mental Illness Research, Education and Clinical Center VISN 3, James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Neuroimage 55:900-8. 2011
    Consistent with the clinical picture of milder symptomatology in schizotypal personality disorder (SPD) than schizophrenia, morphological studies indicate SPD abnormalities in temporal lobe regions but to a much lesser extent in ..
  42. pmc An MRI study of superior temporal gyrus volume in women with schizotypal personality disorder
    Chandlee C Dickey
    VA Boston Healthcare System, Psychiatry 116A, 940 Belmont St, Brockton, MA 02401, USA
    Am J Psychiatry 160:2198-201. 2003
    ..research, and left superior temporal gyrus volume has been shown to be smaller in male subjects with schizotypal personality disorder. This is the first structural magnetic resonance imaging study to examine a group of female subjects ..
  43. pmc The five-factor model in schizotypal personality disorder
    Ronald J Gurrera
    Harvard Medical School, Department of Psychiatry, Boston, MA, USA
    Schizophr Res 80:243-51. 2005
    Studies of the five-factor model of personality in schizotypal personality disorder (SPD) have produced inconsistent results, particularly with respect to openness...
  44. ncbi Volume reduction of the right anterior limb of the internal capsule in patients with schizotypal disorder
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 130:213-25. 2004
    ..Volume deficit confined to the right ALIC suggests that limited involvement of the fronto-thalamic connectivity may have some relevance to the sparing of schizotypal patients from the development of overt psychosis...
  45. doi Schizotypal traits and cognitive function in healthy adults
    Hiroko Noguchi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Psychiatry Res 161:162-9. 2008
    ....
  46. ncbi Cingulate gyrus volume and metabolism in the schizophrenia spectrum
    M Mehmet Haznedar
    Department of Psychiatry, Mount Sinai School of Medicine, Neuroscience PET Laboratory, One Gustave L Levy Place, P O Box 1505, New York, NY 10029 6574, USA
    Schizophr Res 71:249-62. 2004
    ....
  47. doi Visual event-related potentials in schizotypal personality disorder and schizophrenia
    Jenifer L Vohs
    Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN 47405, USA
    J Abnorm Psychol 117:119-31. 2008
    Schizophrenia (SZ) occurs among a spectrum of disorders with similar characteristics, including schizotypal personality disorder (SPD)...
  48. pmc The uncinate fasciculus and extraversion in schizotypal personality disorder: a diffusion tensor imaging study
    Ronald J Gurrera
    Schizophr Res 90:360-2. 2007
  49. pmc The brain in schizotypal personality disorder: a review of structural MRI and CT findings
    Chandlee C Dickey
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Boston, MA 02401, USA
    Harv Rev Psychiatry 10:1-15. 2002
    Studies of schizotypal personality disorder (SPD) are important because the condition is genetically related to schizophrenia and because data accumulating to confirm its biological underpinnings are challenging some traditional views ..
  50. pmc Shape abnormalities of caudate nucleus in schizotypal personality disorder
    James J Levitt
    Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, USA
    Schizophr Res 110:127-39. 2009
    Previously, we reported abnormal volume and global shape in the caudate nucleus in schizotypal personality disorder (SPD)...
  51. ncbi The multidimensionality of self-report schizotypy in a psychiatric population: an analysis using multidimensional Rasch models
    M G Vollema
    Meerkanten GGZ Felvo Veluwe, Veldwijk Psychiatric Hospital Dept of Psychological Assessment, Ermelo, The Netherlands
    Schizophr Bull 26:565-75. 2000
    ..1994) and Gruzelier (1996), yielded the best fit. It consisted of positive schizotypy, disorganization, and negative schizotypy. The results strongly suggest that schizotypy, as measured with the SPQ, is a three-dimensional construct...
  52. ncbi Concurrent validation of schizotaxia: a pilot study
    W S Stone
    Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    Biol Psychiatry 50:434-40. 2001
    ....
  53. ncbi Risperidone in the treatment of schizotypal personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
    J Clin Psychiatry 64:628-34. 2003
    b>Schizotypal personality disorder (SPD) has many phenomenological, genetic, physiologic, and neuroanatomical commonalities with schizophrenia...
  54. ncbi Regional cerebral blood flow during the Wisconsin Card Sort Test in schizotypal personality disorder
    M S Buchsbaum
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Schizophr Res 27:21-8. 1997
    ..blood flow (rCBF) was measured by single photon emission computed tomography in 10 patients with schizotypal personality disorder (SPD) and nine age- and sex-matched normal volunteers...
  55. ncbi Primary and secondary hypohedonia
    P E Meehl
    Department of Psychology, University of Minnesota, Elliott Hall, 75 East River Road, Minneapolis, Minnesota 55455-0344, USA
    J Abnorm Psychol 110:188-93. 2001
    ..To choose between causal interpretations, it could be ascertained whether the schizotypal anhedonic taxon is composed of individuals who are schizotaxic on the basis of psychophysiological, cognitive, and soft neurologic indicators...
  56. ncbi Pre-morbid psychopathology in schizophrenia spectrum
    J Parnas
    University Department of Psychiatry, Kommunehospitalet, Copenhagen, Denmark
    Br J Psychiatry 155:623-7. 1989
    ..Pre-schizophrenics', as compared with 'pre-schizotypes', were characterised by affective dyscontrol, reflected in less introverted and more disturbed behaviour...
  57. pmc Basic symptoms and ultrahigh risk criteria: symptom development in the initial prodromal state
    Frauke Schultze-Lutter
    Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
    Schizophr Bull 36:182-91. 2010
    ..However, as regards the criteria, the results support the notion of BS as at least a complementary approach to the ultrahigh risk criteria, which may also allow for an earlier detection of psychosis...
  58. pmc A qualitative research study of the evolution of symptoms in individuals identified as prodromal to psychosis
    Cheryl Corcoran
    New York State Psychiatric Institute Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Psychiatr Q 74:313-32. 2003
    ..Although preliminary, these results suggest that a trajectory of change in personality, relationships, and behavior from an essentially normal baseline may be consistent with increased risk for psychosis among prodromal adolescents...
  59. ncbi Multiple dimensions of schizotypy in first degree biological relatives of schizophrenia patients
    Monica E Calkins
    University of Pennsylvania School of Medicine, Neuropsychiatry Section, Schizophrenia Research Center, Pittsburgh, PA, USA
    Schizophr Bull 30:317-25. 2004
    ....
  60. ncbi Executive/attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relatives
    A Laurent
    Department of Psychiatry, University Hospital of Grenoble, BP 217 38043, Grenoble, France
    Schizophr Res 46:269-83. 2000
    ..Only two significant correlations were found between the neuropsychological performance and the measures of schizotypy...
  61. ncbi Differential metabolic rates in prefrontal and temporal Brodmann areas in schizophrenia and schizotypal personality disorder
    Monte S Buchsbaum
    Neuroscience PET Laboratory, Department of Psychiatry, Mt Sinai School of Medicine, Box 1505, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Schizophr Res 54:141-50. 2002
    ..spectrum, we compared cortical metabolic rates in unmedicated patients with schizophrenia and schizotypal personality disorder (SPD) with findings in age- and sex-matched normal volunteers...
  62. pmc The empirical status of the ultra high-risk (prodromal) research paradigm
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, CA, USA
    Schizophr Bull 33:661-4. 2007
    ....
  63. pmc Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality Disorder
    Yong Wook Shin
    Department of Psychological and Brain Sciences, Indiana University, 1101 E 10th Street, Bloomington, IN 47405, United States
    Schizophr Res 124:110-8. 2010
    ..Synchronization or timing abnormalities may represent a biomarker for schizophrenia spectrum disorders, and contribute to aberrant perceptual and cognitive integration...
  64. ncbi Duration and not strength of activation in temporo-parietal cortex positively correlates with schizotypy
    Shahar Arzy
    Laboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Neuroimage 35:326-33. 2007
    ..We argue that this might reflect local pathology, pathologies in cortico-cortical connections and/or re-entry of top-down processing...
  65. ncbi Mentalising, schizotypy, and schizophrenia
    R Langdon
    Department of Psychology, Macquarie University, Sydney, NSW, Australia
    Cognition 71:43-71. 1999
    ....
  66. ncbi The pathophysiology of schizophrenia disorders: perspectives from the spectrum
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Am J Psychiatry 161:398-413. 2004
    This overview focuses on neurobiological abnormalities found in subjects with schizotypal personality disorder, the prototype of the schizophrenia spectrum disorders, and chronic schizophrenia in the context of common vulnerabilities ..
  67. pmc Smaller superior temporal gyrus volume specificity in schizotypal personality disorder
    Kim E Goldstein
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Schizophr Res 112:14-23. 2009
    Superior temporal gyrus (STG/BA22) volume is reduced in schizophrenia and to a milder degree in schizotypal personality disorder (SPD), representing a less severe disorder in the schizophrenia spectrum...
  68. ncbi An integration of schizophrenia with schizotypy: identification of schizotaxia and implications for research on treatment and prevention
    Ming T Tsuang
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center MMHC, 74 Fenwood Road, Boston, MA 02115, USA
    Schizophr Res 54:169-75. 2002
    ..Conceptually, this view of schizotaxia is similar to negative schizotypy (i.e., schizotypal personality disorder minus the positive symptoms)...
  69. ncbi Anomalous subjective experience among first-admitted schizophrenia spectrum patients: empirical investigation
    Josef Parnas
    Department of Psychiatry, Copenhagen University, Hvidovre Hospital, Hvidovre, Denmark
    Psychopathology 38:259-67. 2005
    ..In contrast, anomalies of subjective experience were clearly more pronounced among the patients within, as compared to those outside the Sz spectrum...
  70. ncbi Morphologic alterations of the parcellated superior temporal gyrus in schizophrenia spectrum
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 83:131-43. 2006
    ....
  71. ncbi Functional MRI of visuospatial working memory in schizotypal personality disorder: a region-of-interest analysis
    Harold W Koenigsberg
    Bronx Veterans Affairs Medical Center, Bronx 1046, NY, USA
    Psychol Med 35:1019-30. 2005
    ..The study of schizotypal personality disorder (SPD) provides regional analysis in unmedicated patients in the schizophrenia spectrum.
  72. ncbi The initial prodrome of schizophrenia: different duration, different underlying deficits?
    Frauke Schultze-Lutter
    Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
    Compr Psychiatry 48:479-88. 2007
    ....
  73. ncbi Neuromotor functioning in adolescents with schizotypal personality disorder: associations with symptoms and neurocognition
    Craig S Neumann
    Department of Psychology, University of North Texas, Denton 76203 1280, USA
    Schizophr Bull 29:285-98. 2003
    Previously, Neumann and Walker (1999) used a computerized motor assessment and found that adults with schizotypal personality disorder (SPD) displayed increased and more variable motor force compared to adults with other personality ..
  74. ncbi Paul E. Meehl's influence on experimental psychopathology: fruits of the nexus of schizotypy and schizophrenia, neurology, and methodology
    Mark F Lenzenweger
    State University of New York at Binghamton, NY 13902 6000, USA
    J Clin Psychol 61:1295-315. 2005
    ..These contributions have also shaped inquiry into many other psychopathological entities...
  75. ncbi Schizotypy: phenotypic marker as risk factor
    S V Catts
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Aust N Z J Psychiatry 34:S101-7. 2000
    ..To evaluate measures of schizotypy as familial risk factors for schizophrenia with the aim of making recommendations for assessing schizotypy as part of screening procedures for identifying people at risk of schizophrenia...
  76. ncbi Neurobiological measures of schizotypal personality disorder: defining an inhibitory endophenotype?
    Kristin S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0810, USA
    Am J Psychiatry 159:869-71. 2002
    Subjects with schizotypal personality disorder demonstrate deficits in inhibition when assessed on prepulse inhibition, P50 suppression, and antisaccade paradigms...
  77. pmc MRI study of caudate nucleus volume and its cognitive correlates in neuroleptic-naive patients with schizotypal personality disorder
    James J Levitt
    Clinical Neuroscience Division, Laboratory of Neuroscience, Dept of Psychiatry, VA Boston Healthcare System Brockton Division, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
    Am J Psychiatry 159:1190-7. 2002
    ..For this reason, individuals diagnosed with schizotypal personality disorder offer an ideal group for the measurement of the caudate nucleus because they may be genetically ..
  78. ncbi EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorder
    Colleen A Brenner
    Department of Psychology, Indiana University, 1101 East Tenth St, Bloomington, IN 47405, USA
    Am J Psychiatry 160:2238-40. 2003
    The authors tested whether neural synchronization deficits were present in subjects with schizophrenia and schizotypal personality disorder.
  79. ncbi Context-processing deficits in schizotypal personality disorder
    Deanna M Barch
    Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    J Abnorm Psychol 113:556-68. 2004
    Research suggests that schizotypal personality disorder (SPD) is a part of the spectrum of schizophrenia-related illnesses...
  80. doi Schizotypal personality traits and prediction of one's own movements in motor control: what causes an abnormal sense of agency?
    Tomohisa Asai
    Department of Cognitive and Behavioral Science, Graduate School of Arts and Sciences, University of Tokyo, 3 8 1 Komaba, Meguro ku, Tokyo 153 8902, Japan
    Conscious Cogn 17:1131-42. 2008
    ..A sense of agency asserts that it is oneself who is causing or generating an action. It is possible that this abnormal sense of self-agency is attributable to the abnormal prediction of one's own movements in motor control...
  81. ncbi Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia
    R S Keefe
    Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
    Arch Gen Psychiatry 54:169-76. 1997
    Biological relatives of patients with schizophrenia demonstrate an increased prevalence of schizotypal personality disorder symptoms, eye tracking deficits, and attentional disturbances...
  82. ncbi Two-point discrimination thresholds and schizotypy: illuminating a somatosensory dysfunction
    M F Lenzenweger
    Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA
    Schizophr Res 42:111-24. 2000
    ..The results of this study are discussed within a neuropsychological context implicating parietal cortex involvement with schizotypy and schizophrenia...
  83. ncbi Neuropsychological performance in schizotypal personality disorder: importance of working memory
    Vivian Mitropoulou
    Clinical Research Center, Box 1027, Mt Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Am J Psychiatry 162:1896-903. 2005
    Cognitive deficits consistently have been reported in schizophrenia patients and in patients with schizotypal personality disorder. For this study, the authors wanted to identify which of the domains of cognitive impairment represent "..
  84. ncbi Executive/attentional cognitive functions in schizophrenic patients and their parents: a preliminary study
    Sonia Dollfus
    Groupe d Imagerie Neurofonctionnelle, Unité mixte de recherche 6095, CNRS CEA Université de Caen Université Paris V, Centre Cycêron Boulevard Henri Becquerel 14000, Caen, France
    Schizophr Res 53:93-9. 2002
    ..The impairments on the Stroop and fluency could be considered as endophenotypic markers of schizophrenia...
  85. ncbi The Roscommon Family Study. III. Schizophrenia-related personality disorders in relatives
    K S Kendler
    Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond
    Arch Gen Psychiatry 50:781-8. 1993
    ....
  86. ncbi The Schizotypic Syndrome Questionnaire (SSQ): Psychometrics, validation and norms
    Dirk van Kampen
    Vrije Universiteit, Department of Clinical Psychology, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    Schizophr Res 84:305-22. 2006
    ..Because of the implications of the SSQ model for the definition of schizophrenia, the instrument's three-dimensional factor structure and the nature of one of the factors are discussed in more detail...
  87. doi Childhood and current autistic features in adolescents with schizotypal personality disorder
    Michelle L Esterberg
    Emory University Graduate School of Arts and Sciences, Department of Psychology, United States, 1462 Clifton Road, Suite 235, Atlanta, GA 30322, United States
    Schizophr Res 104:265-73. 2008
    ..The present study examined childhood and current signs of autistic disorder (AD) in adolescents with schizotypal personality disorder (SPD) or other personality disorders, as well as healthy controls...
  88. pmc Elevated social Internet use and schizotypal personality disorder in adolescents
    Vijay A Mittal
    Emory University, Psychology, Department of Psychology, 235 Dental Building, 1462 Clifton Road, Atlanta, GA 30322, USA
    Schizophr Res 94:50-7. 2007
    ..study examined the rate of Internet use in adolescents with personality disorders, with a focus on schizotypal personality disorder (SPD), which is characterized by marked interpersonal deficits...
  89. ncbi Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego 92093 0804, USA
    Am J Psychiatry 157:55-9. 2000
    ..schizophrenia spectrum includes individuals with schizophrenia, their relatives, and individuals with schizotypal personality disorder. Subjects in the schizophrenia spectrum have disorders of attention, cognition, and information ..
  90. ncbi Sex differences in digit ratio (2D:4D) are disrupted in adolescents with schizotypal personality disorder: altered prenatal gonadal hormone levels as a risk factor
    Deborah J Walder
    Psychology Department at Brooklyn College City University of New York, Brooklyn, NY 11210, USA
    Schizophr Res 86:118-22. 2006
    ..This study examined 2D:4D in adolescents with schizotypal personality disorder (SPD)...
  91. ncbi Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups
    Michael J Minzenberg
    Bronx Veterans Affairs Medical Center, Bronx, New York, 14068, USA
    Psychiatr Genet 16:117-24. 2006
    ..We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder.
  92. ncbi Minor physical anomalies, dermatoglyphic asymmetries, and cortisol levels in adolescents with schizotypal personality disorder
    D D Weinstein
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Am J Psychiatry 156:617-23. 1999
    A relationship between schizotypal personality disorder and schizophrenia has been documented in behavioral genetic studies, and there are similarities in the cognitive deficits and brain abnormalities associated with these disorders...
  93. ncbi Cognitive functions in schizotypal personality disorder
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Schizophr Res 37:123-32. 1999
    ..Schizotypal personality disordered (SPD) subjects do not have many of the confounds seen in schizophrenic patients, but may have the same pattern of cognitive deficits in attention and executive functioning...
  94. ncbi Wisconsin Card Sorting Test deficits in schizotypic individuals
    D C Gooding
    Department of Psychology, University of Wisconsin Madison 53706 1696, USA
    Schizophr Res 40:201-9. 1999
    ..We identified a subset of schizotypic individuals who also produced clinically deviant WCST profiles. The findings support the hypothesis that executive function deficits may precede the onset of schizophrenia and related illnesses...
  95. ncbi Smooth pursuit eye movements in 1,087 men: effects of schizotypy, anxiety, and depression
    Nikolaos Smyrnis
    University Mental Health Research Institute, Athens, Greece
    Exp Brain Res 179:397-408. 2007
    Individuals with schizotypal personality disorder or high scores in questionnaires measuring schizotypy are at high risk for the development of schizophrenia and they also share some of the same phenotypic characteristics such as eye-..
  96. ncbi Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits
    K S Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0804, USA
    Am J Psychiatry 157:1660-8. 2000
    ..The authors hypothesized that nonschizophrenic relatives of patients with schizophrenia would also have prepulse inhibition deficits, thereby reflecting a genetically transmitted susceptibility to sensorimotor gating deficits...
  97. ncbi Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study
    K S Kendler
    Department of Psychiatry, Medical College of Virginia, Richmond 23298 0710, USA
    Am J Psychiatry 152:749-54. 1995
    ..The authors sought to evaluate whether the pattern of schizophrenia and related disorders in probands and their relatives can be explained by a single underlying continuum of liability to the "schizophrenia spectrum."..
  98. ncbi Striatal size and relative glucose metabolic rate in schizotypal personality disorder and schizophrenia
    L Shihabuddin
    Bronx Veterans Affairs Medical Center, Mental Health Patient Care Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
    Arch Gen Psychiatry 58:877-84. 2001
    b>Schizotypal personality disorder (SPD) shares social deficits and cognitive impairment with schizophrenia, but is not typically characterized by frank psychosis...
  99. ncbi Do schizotypal symptoms mediate the relationship between genetic risk for schizophrenia and impaired neuropsychological performance in co-twins of schizophrenic patients?
    Jennifer K Johnson
    Department of Psychology JKJ, University of California at Los Angeles, Los Angeles, California California 90095 1563, USA
    Biol Psychiatry 54:1200-4. 2003
    Neurocognitive deficits and symptoms of schizotypal personality disorder are both elevated in the first-degree relatives of schizophrenic patients, but their relationship to each other and their potential common genetic source remain ..
  100. ncbi Self-face recognition is affected by schizotypal personality traits
    Steven M Platek
    Department of Psychology, State University of New York at Albany, 1400 Washington Avenue, Albany, NY 12222, USA
    Schizophr Res 57:81-5. 2002
    ..Our data are the first to show that traits associated with a schizophrenic spectrum disorder in a non-clinical population may compromise self-face recognition...
  101. ncbi Neuropsychological performance in schizotypal personality disorder: evidence regarding diagnostic specificity
    Vivian Mitropoulou
    Mt Sinai School of Medicine, Department of Psychiatry, The Bronx Veterans Affairs Medical Center, New York, New York, USA
    Biol Psychiatry 52:1175-82. 2002
    Individuals with schizotypal personality disorder (SPD) share cognitive deficits with schizophrenic patients, suggesting that these deficits represent a core feature of the schizophrenia spectrum...

Research Grants100

  1. PHARMACOLOGY OF COGNITION IN SCHIZOTYPAL PERSONALITY
    Larry Siever; Fiscal Year: 2003
    The proposed studies are designed to characterize the cognitive impairment associated with schizotypal personality disorder (SPD) using a cognitive battery including recently developed tests to evaluate the effect of a pharmacologic ..
  2. Cognitive Control Deficits and Formal Thought Disorder
    JOHN KERNS; Fiscal Year: 2005
    ..abstract_text> ..
  3. ANATOMY AND FUNCTION OF THE THALAMUS IN SCHIZOPHRENIA
    Monte Buchsbaum; Fiscal Year: 2007
    ..41 unmedicated patients with schizophrenia and 60 normal controls and a group of 12 patients with schizotypal personality disorder. This confirmed smaller volumes of the medial dorsal and pulvinar in patients with schizophrenia and ..
  4. Pharmacology of Cognition in Schizotypal Personality Disorder
    Larry Siever; Fiscal Year: 2007
    ..study is designed to specifically evaluate: (1) the working memory impairment associated with schizotypal personality disorder (SPD), assessing components of manipulation and maintenance as delineated in Baddeley's comprehensive ..
  5. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin S Cadenhead; Fiscal Year: 2010
    ..The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
  6. BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDER
    ROBERT MC CARLEY; Fiscal Year: 2009
    The biological basis of schizotypal personality disorder (SPD) is of intrinsic interest and also important because it bears closely on the nature of schizophrenia (SZ) and "SZ spectrum disorders"...
  7. BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDER
    ROBERT MC CARLEY; Fiscal Year: 2007
    The biological basis of schizotypal personality disorder (SPD) is of intrinsic interest and also important because it bears closely on the nature of schizophrenia (SZ) and "SZ spectrum disorders"...
  8. Pharmacology of Cognition in Schizotypal Personality Disorder
    Larry J Siever; Fiscal Year: 2010
    ..study is designed to specifically evaluate: (1) the working memory impairment associated with schizotypal personality disorder (SPD), assessing components of manipulation and maintenance as delineated in Baddeley's ..
  9. BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDER
    ROBERT MC CARLEY; Fiscal Year: 2003
    ..5-year multidisciplinary research study is to advance our understanding of the biological basis of schizotypal personality disorder (SPD), using neuropsychological, electrophysiological, and magnetic resonance imaging (MRI) studies ..
  10. Prediction of Psychosis in Schizotypal Adolescents
    Elaine Walker; Fiscal Year: 2006
    ..Findings from our preliminary research indicate that adolescents with schizotypal personality disorder (SPD) manifest several physical indicators that have been observed in schizophrenia patients, ..
  11. PHARMACOLOGY OF COGNITION IN SCHIZOTYPAL PERSONALITY
    Larry Siever; Fiscal Year: 2006
    The proposed studies are designed to characterize the cognitive impairment associated with schizotypal personality disorder (SPD) using a cognitive battery including recently developed tests to evaluate the effect of a pharmacologic ..
  12. Computational Morphometry in Schizophrenia and Related Disorders
    Sylvain Bouix; Fiscal Year: 2010
    ..including, but not limited to, normal neurodevelopment, Alzheimer's disease, schizophrenia and schizotypal personality disorder (SPD), bipolar disorder, psychotic affective disorder, and fetal alcohol exposure...
  13. THE NEURAL CIRCUITRY OF SENSORIMOTOR GATING
    Erin Hazlett; Fiscal Year: 2002
    ....
  14. Neural Substrates of Emotion in Borderline Patients
    Erin Hazlett; Fiscal Year: 2007
    ..Axis I disorder or Cluster A or C personality disorders), 26 non-BPD patients (with a diagnosis of schizotypal personality disorder and no comorbid Cluster B or C personality disorders or Axis I disorder) and 26 healthy controls...
  15. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2007
    ..The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
  16. Vulnerability Markers in the Prodrome and First Episode of Schizophrenia
    Kristin Cadenhead; Fiscal Year: 2007
    ....
  17. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin Cadenhead; Fiscal Year: 2004
    ..The disruption of social networks, education and occupational activity as well as the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
  18. VIOLENCE--INTEGRATING SOCIAL AND PHYSIOLOGICAL FACTORS
    Adrian Raine; Fiscal Year: 2003
    ....
  19. 3/3-Improving Metabolic Parameters of Antipsychotic Child Treatment (IMPACT)
    Christoph U Correll; Fiscal Year: 2010
    ..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..
  20. Anterior Cingulate, Prefrontal Cortex, and Conflict-Control Loop Theory
    JOHN KERNS; Fiscal Year: 2006
    ..abstract_text> ..
  21. Enhancing the Prospective Prediction of Psychosis
    Jean Addington; Fiscal Year: 2007
    ..Each site has proven its ability to recruit prodromal patients in a previous collaboration. ..
  22. EARLY DETECTION AND INTERVENTION IN PSYCHOSIS
    Thomas McGlashan; Fiscal Year: 2003
    ..studies as follows: 4) Ascertaining the frequency, nature, and consequences of prodromal states in Schizotypal Personality Disorder and 5) The epidemiology of prodromal states in first degree relatives of schizophrenic patients in ..
  23. TARDIVE DYSKINESIA INCIDENCE AND ATYPICAL ANTIPSYCHOTIC
    Scott Woods; Fiscal Year: 2004
    ..The existence of a previous sample at the same site provides a useful additional comparison group. Methods including sample ascertainment and TD assessment are closely modeled after the original work. ..
  24. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Scott Woods; Fiscal Year: 1999
    ..Nonresponders will be randomized to a study comparing paroxetine with continued CBT. In addition to the main questions, possible predictors of response and relapse will be examined as well as possible mediators of response. ..
  25. Sensory Processing Deficits in Cannabis Use
    PATRICK SKOSNIK; Fiscal Year: 2006
    ..Taken together, this data may serve to elucidate whether the known cognitive dysfunction observed in cannabis use is in part related to disturbances in early sensory information processing and/or neural synchronization. ..
  26. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Matcheri Keshavan; Fiscal Year: 2007
    ....
  27. Neurologic Predictors of Schizophrenia
    Jason Schiffman; Fiscal Year: 2007
    ....
  28. The Effect of Cannabis Use on Human Cerebellar Function
    PATRICK SKOSNIK; Fiscal Year: 2007
    ..Taken together, data from these studies will further our understanding of the cannabinoid system, which will help elucidate the mechanism of action of one of the most commonly used drugs of abuse.Project Narrative ..
  29. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Matcheri Keshavan; Fiscal Year: 2009
    ....