Genomes and Genes
schizotypal personality disorder
Summary: A personality disorder in which there are oddities of thought (magical thinking, paranoid ideation, suspiciousness), perception (illusions, depersonalization), speech (digressive, vague, overelaborate), and behavior (inappropriate affect in social interactions, frequently social isolation) that are not severe enough to characterize schizophrenia.
Publications235 found, 100 shown here
- Clinical characteristics of first-admitted patients with ICD-10 schizotypal disorderPeter Handest
University Department of Psychiatry, Hvidovre Hospital, Brøndby stervej 160, 2605 Brønby, Denmark
Br J Psychiatry Suppl 48:s49-54. 2005..The clinical picture of schizotypal disorders is rarely comprehensively described...
- Smaller superior temporal gyrus volume specificity in schizotypal personality disorderKim E Goldstein
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Schizophr Res 112:14-23. 2009Superior temporal gyrus (STG/BA22) volume is reduced in schizophrenia and to a milder degree in schizotypal personality disorder (SPD), representing a less severe disorder in the schizophrenia spectrum...
- Anomalous subjective experience among first-admitted schizophrenia spectrum patients: empirical investigationJosef Parnas
Department of Psychiatry, Copenhagen University, Hvidovre Hospital, Hvidovre, Denmark
Psychopathology 38:259-67. 2005..In contrast, anomalies of subjective experience were clearly more pronounced among the patients within, as compared to those outside the Sz spectrum...
- Magnetic resonance imaging of the thalamic mediodorsal nucleus and pulvinar in schizophrenia and schizotypal personality disorderW Byne
Mount Sinai School of Medicine, New York, NY, USA
Arch Gen Psychiatry 58:133-40. 2001..Because frontal and temporal lobe volumes are diminished in schizophrenia, volume loss could characterize their primary thalamic relay nuclei (mediodorsal nucleus [MDN] and pulvinar)...
- Schizotypy in community samples: the three-factor structure and correlation with sustained attentionW J Chen
Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei
J Abnorm Psychol 106:649-54. 1997..The PAS differed from the Cognitive-Perceptual factor in its consistent association with poorer attention in both samples. These have important implications for the scales in the early detection of the schizotypy in various cultures...
- Anxiety and depression symptoms in psychometrically identified schizotypyKathryn E Lewandowski
University of North Carolina at Greensboro, Department of Psychology, 296 Eberhart Building, Greensboro, NC 27402, USA
Schizophr Res 83:225-35. 2006....
- Temporal lobe volume determined by magnetic resonance imaging in schizotypal personality disorder and schizophreniaJ E Downhill
Department of Psychiatry, Neuroscience PET Lab, Box 1505, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
Schizophr Res 48:187-99. 2001..gyrus and the corpus callosum were measured on magnetic resonance images from 13 patients with schizotypal personality disorder (SPD), 27 patients with schizophrenia, and 31 age- and sex-matched controls...
- Schizotypal personality: neurodevelopmental and psychosocial trajectoriesAdrian Raine
Department of Psychology and Neuroscience Program, University of Southern California, Los Angeles, California 90089 1061, USA
Annu Rev Clin Psychol 2:291-326. 2006....
- Morphologic alterations of the parcellated superior temporal gyrus in schizophrenia spectrumTsutomu Takahashi
Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Schizophr Res 83:131-43. 2006....
- Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk?Alison R Yung
ORYGEN Research Centre, 35 Poplar Road, Parkville 3052, Victoria, Australia
Schizophr Bull 33:673-81. 2007..Patients presenting to them need help. It may be that we need to aim to prevent a range of target syndromes...
- Schizotypy facets, cognitive control, and emotionJohn G Kerns
Department of Psychological Sciences, University of Missouri Columbia, 65211, USA
J Abnorm Psychol 115:418-27. 2006....
- An integration of schizophrenia with schizotypy: identification of schizotaxia and implications for research on treatment and preventionMing T Tsuang
Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center MMHC, 74 Fenwood Road, Boston, MA 02115, USA
Schizophr Res 54:169-75. 2002..Conceptually, this view of schizotaxia is similar to negative schizotypy (i.e., schizotypal personality disorder minus the positive symptoms)...
- Emotional correlates of the different dimensions of schizotypal personality disorderHoward Berenbaum
Department of Psychology, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
J Abnorm Psychol 115:359-68. 2006Two studies explored which different dimensions of schizotypal personality disorder (SPD) were associated with negative affect, attention to emotions, clarity of emotions, and emotional intensity/instability...
- Looking at the schizophrenia spectrum through the prism of self-disorders: an empirical studyAndrea Raballo
Danish National Research Foundation Center for Subjectivity Research, University of Copenhagen, Copenhagen S, Denmark
Schizophr Bull 37:344-51. 2011..Manual of Mental Disorders (Third Edition Revised) main diagnosis: schizophrenia, (n = 29), schizotypal personality disorder (n = 61), other mental illness not belonging to the schizophrenia spectrum (n = 112), and no mental ..
- Duration and not strength of activation in temporo-parietal cortex positively correlates with schizotypyShahar Arzy
Laboratory of Cognitive Neuroscience, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Neuroimage 35:326-33. 2007..We argue that this might reflect local pathology, pathologies in cortico-cortical connections and/or re-entry of top-down processing...
- Social anhedonia as a predictor of the development of schizophrenia-spectrum disordersT R Kwapil
Department of Psychology, University of Wisconsin, Madison, USA
J Abnorm Psychol 107:558-65. 1998..Thus, the SocAnh Scale, unlike the Perceptual Aberration and Magical Ideation Scales, appears to identify individuals at specific risk for future development of schizophrenia-spectrum disorders...
- Hedonic capacity and schizotypy revisited: a taxometric analysis of social anhedoniaJ J Blanchard
Department of Psychology, University of New Mexico, USA
J Abnorm Psychol 109:87-95. 2000..10. These data are interpreted in the context of other findings suggesting that social anhedonia is an indicator of schizotypy...
- Objective measures of prospective memory do not correlate with subjective complaints in schizophreniaRaymond C K Chan
Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
Schizophr Res 103:229-39. 2008..poorer performance in all domains of memory function except visual memory than individuals with schizotypal personality disorder and healthy controls...
- Emotion processing in persons at risk for schizophreniaLaura K Phillips
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Schizophr Bull 34:888-903. 2008..The most robust findings in at-risk groups are in the areas of reduced emotion perception, self-reported anhedonia, and increased negative affect. We conclude with an agenda for future research...
- The five-factor model in schizotypal personality disorderRonald J Gurrera
Harvard Medical School, Department of Psychiatry, Boston, MA, USA
Schizophr Res 80:243-51. 2005Studies of the five-factor model of personality in schizotypal personality disorder (SPD) have produced inconsistent results, particularly with respect to openness...
- Schizotypal traits and cognitive function in healthy adultsHiroko Noguchi
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
Psychiatry Res 161:162-9. 2008....
- Emotion dysregulation and schizotypyJulie D Henry
School of Psychology, University of New South Wales, Sydney, NSW 2052 Australia
Psychiatry Res 166:116-24. 2009..Implications for understanding blunted affect in schizophrenia and related disorders are discussed...
- Shape abnormalities of caudate nucleus in schizotypal personality disorderJames J Levitt
Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, USA
Schizophr Res 110:127-39. 2009Previously, we reported abnormal volume and global shape in the caudate nucleus in schizotypal personality disorder (SPD)...
- The uncinate fasciculus and extraversion in schizotypal personality disorder: a diffusion tensor imaging studyRonald J Gurrera
Schizophr Res 90:360-2. 2007
- Heritability and longitudinal stability of schizotypal traits during adolescenceMarissa Ericson
Department of Psychology SGM 501, University of Southern California, Los Angeles, CA 90089 1061, USA
Behav Genet 41:499-511. 2011....
- Volume reduction of the right anterior limb of the internal capsule in patients with schizotypal disorderMichio Suzuki
Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
Psychiatry Res 130:213-25. 2004..Volume deficit confined to the right ALIC suggests that limited involvement of the fronto-thalamic connectivity may have some relevance to the sparing of schizotypal patients from the development of overt psychosis...
- Neuromotor functioning in adolescents with schizotypal personality disorder: associations with symptoms and neurocognitionCraig S Neumann
Department of Psychology, University of North Texas, Denton 76203 1280, USA
Schizophr Bull 29:285-98. 2003Previously, Neumann and Walker (1999) used a computerized motor assessment and found that adults with schizotypal personality disorder (SPD) displayed increased and more variable motor force compared to adults with other personality ..
- Prefrontal structural and functional deficits in schizotypal personality disorderAdrian Raine
Department of Psychology, University of Southern California, Los Angeles, CA 90089 1061, USA
Schizophr Bull 28:501-13. 2002....
- Cingulate and temporal lobe fractional anisotropy in schizotypal personality disorderErin A Hazlett
Mental Illness Research, Education and Clinical Center VISN 3, James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
Neuroimage 55:900-8. 2011Consistent with the clinical picture of milder symptomatology in schizotypal personality disorder (SPD) than schizophrenia, morphological studies indicate SPD abnormalities in temporal lobe regions but to a much lesser extent in ..
- A follow-up MRI study of the superior temporal subregions in schizotypal disorder and first-episode schizophreniaTsutomu Takahashi
Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Schizophr Res 119:65-74. 2010....
- An MRI study of superior temporal gyrus volume in women with schizotypal personality disorderChandlee C Dickey
VA Boston Healthcare System, Psychiatry 116A, 940 Belmont St, Brockton, MA 02401, USA
Am J Psychiatry 160:2198-201. 2003..research, and left superior temporal gyrus volume has been shown to be smaller in male subjects with schizotypal personality disorder. This is the first structural magnetic resonance imaging study to examine a group of female subjects ..
- Neurocognitive, behavioural and neurodevelopmental correlates of schizotypy clusters in adolescents from the general populationNeus Barrantes-Vidal
Departament de Psicologia de la Salut, Facultat de Psicologia, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
Schizophr Res 61:293-302. 2003..We aimed to establish clusters of normal adolescents based on schizotypy dimensions and compare them on neurocognitive, behavioural, and neurodevelopmental markers...
- Sustained attention deficits in relation to psychometrically identified schizotypy: evaluating a potential endophenotypic markerDiane C Gooding
University of Wisconsin Madison, Department of Psychology, Madison, WI 53706, USA
Schizophr Res 82:27-37. 2006..The findings add to the converging evidence indicating that sustained attention deficits are a potential endophenotypic indicator of a schizophrenia diathesis...
- Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A geneYuka Yasuda
Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
Neurosci Lett 495:216-20. 2011..an increased risk not only for schizophrenia but also for schizophrenia spectrum disorders, such as schizotypal personality disorder. A single nucleotide polymorphism (SNP), rs1344706, in the Zinc Finger Protein 804A (ZNF804A) gene, ..
- MRI abnormalities of the hippocampus and cavum septi pellucidi in females with schizotypal personality disorderChandlee C Dickey
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA
Schizophr Res 89:49-58. 2007This study examined MRI hippocampal volume and cavum septi pellucidi (CSP) in female subjects with schizotypal personality disorder (SPD) and comparison subjects.
- The multidimensionality of self-report schizotypy in a psychiatric population: an analysis using multidimensional Rasch modelsM G Vollema
Meerkanten GGZ Felvo Veluwe, Veldwijk Psychiatric Hospital Dept of Psychological Assessment, Ermelo, The Netherlands
Schizophr Bull 26:565-75. 2000..1994) and Gruzelier (1996), yielded the best fit. It consisted of positive schizotypy, disorganization, and negative schizotypy. The results strongly suggest that schizotypy, as measured with the SPQ, is a three-dimensional construct...
- The brain in schizotypal personality disorder: a review of structural MRI and CT findingsChandlee C Dickey
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Boston, MA 02401, USA
Harv Rev Psychiatry 10:1-15. 2002Studies of schizotypal personality disorder (SPD) are important because the condition is genetically related to schizophrenia and because data accumulating to confirm its biological underpinnings are challenging some traditional views ..
- The effects of guanfacine on context processing abnormalities in schizotypal personality disorderMargaret M McClure
VA VISN3 Mental Illness Research, Education, and Clinical Center, Bronx, New York 10468, USA
Biol Psychiatry 61:1157-60. 2007The signature of impaired cognition in people with schizotypal personality disorder (SPD) may be centrally related to working memory impairments...
- Visual event-related potentials in schizotypal personality disorder and schizophreniaJenifer L Vohs
Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN 47405, USA
J Abnorm Psychol 117:119-31. 2008Schizophrenia (SZ) occurs among a spectrum of disorders with similar characteristics, including schizotypal personality disorder (SPD)...
- Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity alleleFranck Schurhoff
Département Hospitalo Universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor, 40 rue Mesly, Creteil, France
Am J Med Genet B Neuropsychiatr Genet 144:64-8. 2007....
- Saccadic eye movements, schizotypy, and the role of neuroticismUlrich Ettinger
Department of Psychology, McGill University, Stewart Biological Sciences Building, 1205 Dr Penfield Ave, Montreal, Que, Canada H3A 1B1
Biol Psychol 68:61-78. 2005..We conclude that saccadic performance patterns in schizotypy are not due to negative emotionality or general psychopathology, but specific to schizophrenia spectrum signs and symptoms...
- Cingulate gyrus volume and metabolism in the schizophrenia spectrumM Mehmet Haznedar
Department of Psychiatry, Mount Sinai School of Medicine, Neuroscience PET Laboratory, One Gustave L Levy Place, P O Box 1505, New York, NY 10029 6574, USA
Schizophr Res 71:249-62. 2004....
- Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorderTsutomu Takahashi
Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
Eur Arch Psychiatry Clin Neurosci 252:268-77. 2002..These results suggest that both schizotypal and schizophrenic subjects share, at least in part, the same cerebral asymmetry abnormalities...
- Smaller left Heschl's gyrus volume in patients with schizotypal personality disorderChandlee C Dickey
Harvard Medical School, Clinical Neuroscience Division, Department of Psychiatry, VA Boston Healthcare System, Brockton, MA 02401, USA
Am J Psychiatry 159:1521-7. 2002..Magnetic resonance imaging (MRI) studies have shown smaller gray matter volume in patients with schizotypal personality disorder than in matched comparison subjects in the left superior temporal gyrus, an area important for ..
- A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese populationXiaohong Ma
Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China
Psychiatry Res 153:7-15. 2007..Molecular Psychiatry 7, 706-711]. We conclude that SNP Val158Met (rs4680) in the COMT gene may be associated with some schizotypal traits in male subjects, but our results are not conclusive...
- Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality DisorderYong Wook Shin
Department of Psychological and Brain Sciences, Indiana University, 1101 E 10th Street, Bloomington, IN 47405, United States
Schizophr Res 124:110-8. 2010..Synchronization or timing abnormalities may represent a biomarker for schizophrenia spectrum disorders, and contribute to aberrant perceptual and cognitive integration...
- The empirical status of the ultra high-risk (prodromal) research paradigmTyrone D Cannon
Department of Psychology, University of California, Los Angeles, CA, USA
Schizophr Bull 33:661-4. 2007....
- Executive/attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relativesA Laurent
Department of Psychiatry, University Hospital of Grenoble, BP 217 38043, Grenoble, France
Schizophr Res 46:269-83. 2000..Only two significant correlations were found between the neuropsychological performance and the measures of schizotypy...
- Basic symptoms and ultrahigh risk criteria: symptom development in the initial prodromal stateFrauke Schultze-Lutter
Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
Schizophr Bull 36:182-91. 2010..However, as regards the criteria, the results support the notion of BS as at least a complementary approach to the ultrahigh risk criteria, which may also allow for an earlier detection of psychosis...
- Reduced Kamin blocking in non paranoid schizophrenia: associations with schizotypyP M Moran
School of Psychology, University of Leicester, University Road, Leicester LE1 7RH, UK
J Psychiatr Res 37:155-63. 2003....
- Perceptual aberrations impair mental own-body transformationsC Mohr
Department of Experimental Psychology, University of Bristol, Bristol, United Kingdom
Behav Neurosci 120:528-34. 2006....
- Risperidone in the treatment of schizotypal personality disorderHarold W Koenigsberg
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
J Clin Psychiatry 64:628-34. 2003OBJECTIVE: Schizotypal personality disorder (SPD) has many phenomenological, genetic, physiologic, and neuroanatomical commonalities with schizophrenia...
- The initial prodrome of schizophrenia: different duration, different underlying deficits?Frauke Schultze-Lutter
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Compr Psychiatry 48:479-88. 2007....
- Pre-morbid psychopathology in schizophrenia spectrumJ Parnas
University Department of Psychiatry, Kommunehospitalet, Copenhagen, Denmark
Br J Psychiatry 155:623-7. 1989..Pre-schizophrenics', as compared with 'pre-schizotypes', were characterised by affective dyscontrol, reflected in less introverted and more disturbed behaviour...
- Paul E. Meehl's influence on experimental psychopathology: fruits of the nexus of schizotypy and schizophrenia, neurology, and methodologyMark F Lenzenweger
State University of New York at Binghamton, NY 13902 6000, USA
J Clin Psychol 61:1295-315. 2005..These contributions have also shaped inquiry into many other psychopathological entities...
- Schizotypy: phenotypic marker as risk factorS V Catts
School of Psychiatry, University of New South Wales, Sydney, Australia
Aust N Z J Psychiatry 34:S101-7. 2000..To evaluate measures of schizotypy as familial risk factors for schizophrenia with the aim of making recommendations for assessing schizotypy as part of screening procedures for identifying people at risk of schizophrenia...
- Multiple dimensions of schizotypy in first degree biological relatives of schizophrenia patientsMonica E Calkins
University of Pennsylvania School of Medicine, Neuropsychiatry Section, Schizophrenia Research Center, Pittsburgh, PA, USA
Schizophr Bull 30:317-25. 2004....
- Primary and secondary hypohedoniaP E Meehl
Department of Psychology, University of Minnesota, Elliott Hall, 75 East River Road, Minneapolis, Minnesota 55455-0344, USA
J Abnorm Psychol 110:188-93. 2001..To choose between causal interpretations, it could be ascertained whether the schizotypal anhedonic taxon is composed of individuals who are schizotaxic on the basis of psychophysiological, cognitive, and soft neurologic indicators...
- Differential metabolic rates in prefrontal and temporal Brodmann areas in schizophrenia and schizotypal personality disorderMonte S Buchsbaum
Neuroscience PET Laboratory, Department of Psychiatry, Mt Sinai School of Medicine, Box 1505, One Gustave L Levy Place, New York, NY 10029 6574, USA
Schizophr Res 54:141-50. 2002..spectrum, we compared cortical metabolic rates in unmedicated patients with schizophrenia and schizotypal personality disorder (SPD) with findings in age- and sex-matched normal volunteers...
- Regional cerebral blood flow during the Wisconsin Card Sort Test in schizotypal personality disorderM S Buchsbaum
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Schizophr Res 27:21-8. 1997..blood flow (rCBF) was measured by single photon emission computed tomography in 10 patients with schizotypal personality disorder (SPD) and nine age- and sex-matched normal volunteers...
- A qualitative research study of the evolution of symptoms in individuals identified as prodromal to psychosisCheryl Corcoran
New York State Psychiatric Institute Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
Psychiatr Q 74:313-32. 2003..Although preliminary, these results suggest that a trajectory of change in personality, relationships, and behavior from an essentially normal baseline may be consistent with increased risk for psychosis among prodromal adolescents...
- Concurrent validation of schizotaxia: a pilot studyW S Stone
Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
Biol Psychiatry 50:434-40. 2001....
- Mentalising, schizotypy, and schizophreniaR Langdon
Department of Psychology, Macquarie University, Sydney, NSW, Australia
Cognition 71:43-71. 1999....
- Two-point discrimination thresholds and schizotypy: illuminating a somatosensory dysfunctionM F Lenzenweger
Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA
Schizophr Res 42:111-24. 2000..The results of this study are discussed within a neuropsychological context implicating parietal cortex involvement with schizotypy and schizophrenia...
- EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorderColleen A Brenner
Department of Psychology, Indiana University, 1101 East Tenth St, Bloomington, IN 47405, USA
Am J Psychiatry 160:2238-40. 2003..tested whether neural synchronization deficits were present in subjects with schizophrenia and schizotypal personality disorder. METHOD: Amplitude-modulated tones were used to evaluate auditory steady-state evoked potential ..
- Context-processing deficits in schizotypal personality disorderDeanna M Barch
Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
J Abnorm Psychol 113:556-68. 2004Research suggests that schizotypal personality disorder (SPD) is a part of the spectrum of schizophrenia-related illnesses...
- Neuropsychological performance in schizotypal personality disorder: importance of working memoryVivian Mitropoulou
Clinical Research Center, Box 1027, Mt Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
Am J Psychiatry 162:1896-903. 2005Cognitive deficits consistently have been reported in schizophrenia patients and in patients with schizotypal personality disorder. For this study, the authors wanted to identify which of the domains of cognitive impairment represent &..
- Neurobiological measures of schizotypal personality disorder: defining an inhibitory endophenotype?Kristin S Cadenhead
Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0810, USA
Am J Psychiatry 159:869-71. 2002Subjects with schizotypal personality disorder demonstrate deficits in inhibition when assessed on prepulse inhibition, P50 suppression, and antisaccade paradigms...
- Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorderK S Cadenhead
Department of Psychiatry, University of California, San Diego 92093 0804, USA
Am J Psychiatry 157:55-9. 2000..schizophrenia spectrum includes individuals with schizophrenia, their relatives, and individuals with schizotypal personality disorder. Subjects in the schizophrenia spectrum have disorders of attention, cognition, and information ..
- Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groupsMichael J Minzenberg
Bronx Veterans Affairs Medical Center, Bronx, New York, 14068, USA
Psychiatr Genet 16:117-24. 2006..We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder.
- Topographic abnormalities of P3 in schizotypal personality disorderD F Salisbury
Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, Boston, USA
Biol Psychiatry 40:165-72. 1996..Asymmetry of P3 amplitude, with left-sided deficit, may be associated with the schizophrenia diathesis, but overall P3 reductions may be more associated with chronic effects...
- Elevated social Internet use and schizotypal personality disorder in adolescentsVijay A Mittal
Emory University, Psychology, Department of Psychology, 235 Dental Building, 1462 Clifton Road, Atlanta, GA 30322, USA
Schizophr Res 94:50-7. 2007..study examined the rate of Internet use in adolescents with personality disorders, with a focus on schizotypal personality disorder (SPD), which is characterized by marked interpersonal deficits...
- The Schizotypic Syndrome Questionnaire (SSQ): Psychometrics, validation and normsDirk van Kampen
Vrije Universiteit, Department of Clinical Psychology, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
Schizophr Res 84:305-22. 2006..Because of the implications of the SSQ model for the definition of schizophrenia, the instrument's three-dimensional factor structure and the nature of one of the factors are discussed in more detail...
- Executive/attentional cognitive functions in schizophrenic patients and their parents: a preliminary studySonia Dollfus
Groupe d Imagerie Neurofonctionnelle, Unité mixte de recherche 6095, CNRS CEA Université de Caen Université Paris V, Centre Cycêron Boulevard Henri Becquerel 14000, Caen, France
Schizophr Res 53:93-9. 2002..The impairments on the Stroop and fluency could be considered as endophenotypic markers of schizophrenia...
- Schizotypal personality traits and prediction of one's own movements in motor control: what causes an abnormal sense of agency?Tomohisa Asai
Department of Cognitive and Behavioral Science, Graduate School of Arts and Sciences, University of Tokyo, 3 8 1 Komaba, Meguro ku, Tokyo 153 8902, Japan
Conscious Cogn 17:1131-42. 2008..A sense of agency asserts that it is oneself who is causing or generating an action. It is possible that this abnormal sense of self-agency is attributable to the abnormal prediction of one's own movements in motor control...
- Childhood and current autistic features in adolescents with schizotypal personality disorderMichelle L Esterberg
Emory University Graduate School of Arts and Sciences, Department of Psychology, United States, 1462 Clifton Road, Suite 235, Atlanta, GA 30322, United States
Schizophr Res 104:265-73. 2008..The present study examined childhood and current signs of autistic disorder (AD) in adolescents with schizotypal personality disorder (SPD) or other personality disorders, as well as healthy controls...
- MRI study of caudate nucleus volume and its cognitive correlates in neuroleptic-naive patients with schizotypal personality disorderJames J Levitt
Clinical Neuroscience Division, Laboratory of Neuroscience, Dept. of Psychiatry, VA Boston Healthcare System-Brockton Division, Harvard Medical School, 940 Belmont Street, Brockton, MA 02301, USA
Am J Psychiatry 159:1190-7. 2002..For this reason, individuals diagnosed with schizotypal personality disorder offer an ideal group for the measurement of the caudate nucleus because they may be genetically ..
- The Roscommon Family Study. III. Schizophrenia-related personality disorders in relativesK S Kendler
Department of Psychiatry, Medical College of Virginia Virginia Commonwealth University, Richmond
Arch Gen Psychiatry 50:781-8. 1993....
- Sex differences in digit ratio (2D:4D) are disrupted in adolescents with schizotypal personality disorder: altered prenatal gonadal hormone levels as a risk factorDeborah J Walder
Psychology Department at Brooklyn College City University of New York, Brooklyn, NY 11210, USA
Schizophr Res 86:118-22. 2006..This study examined 2D:4D in adolescents with schizotypal personality disorder (SPD)...
- Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophreniaR S Keefe
Department of Psychiatry, Mount Sinai School of Medicine, New York, USA
Arch Gen Psychiatry 54:169-76. 1997Biological relatives of patients with schizophrenia demonstrate an increased prevalence of schizotypal personality disorder symptoms, eye tracking deficits, and attentional disturbances...
- Cognitive functions in schizotypal personality disorderK S Cadenhead
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
Schizophr Res 37:123-32. 1999..Schizotypal personality disordered (SPD) subjects do not have many of the confounds seen in schizophrenic patients, but may have the same pattern of cognitive deficits in attention and executive functioning...
- Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficitsK S Cadenhead
Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0804, USA
Am J Psychiatry 157:1660-8. 2000..The authors hypothesized that nonschizophrenic relatives of patients with schizophrenia would also have prepulse inhibition deficits, thereby reflecting a genetically transmitted susceptibility to sensorimotor gating deficits...
- Minor physical anomalies, dermatoglyphic asymmetries, and cortisol levels in adolescents with schizotypal personality disorderD D Weinstein
Department of Psychology, Emory University, Atlanta, GA 30322, USA
Am J Psychiatry 156:617-23. 1999A relationship between schizotypal personality disorder and schizophrenia has been documented in behavioral genetic studies, and there are similarities in the cognitive deficits and brain abnormalities associated with these disorders...
- Self-face recognition is affected by schizotypal personality traitsSteven M Platek
Department of Psychology, State University of New York at Albany, 1400 Washington Avenue, Albany, NY 12222, USA
Schizophr Res 57:81-5. 2002..Our data are the first to show that traits associated with a schizophrenic spectrum disorder in a non-clinical population may compromise self-face recognition...
- Striatal size and relative glucose metabolic rate in schizotypal personality disorder and schizophreniaL Shihabuddin
Bronx Veterans Affairs Medical Center, Mental Health Patient Care Center, 130 W Kingsbridge Rd, Bronx, NY 10468, USA
Arch Gen Psychiatry 58:877-84. 2001b>Schizotypal personality disorder (SPD) shares social deficits and cognitive impairment with schizophrenia, but is not typically characterized by frank psychosis...
- Neuropsychological performance in schizotypal personality disorder: evidence regarding diagnostic specificityVivian Mitropoulou
Mt. Sinai School of Medicine, Department of Psychiatry, The Bronx Veterans Affairs Medical Center, New York, New York, USA
Biol Psychiatry 52:1175-82. 2002BACKGROUND: Individuals with schizotypal personality disorder (SPD) share cognitive deficits with schizophrenic patients, suggesting that these deficits represent a core feature of the schizophrenia spectrum...
- Smooth pursuit eye movements in 1,087 men: effects of schizotypy, anxiety, and depressionNikolaos Smyrnis
University Mental Health Research Institute, Athens, Greece
Exp Brain Res 179:397-408. 2007Individuals with schizotypal personality disorder or high scores in questionnaires measuring schizotypy are at high risk for the development of schizophrenia and they also share some of the same phenotypic characteristics such as eye-..
- Do schizotypal symptoms mediate the relationship between genetic risk for schizophrenia and impaired neuropsychological performance in co-twins of schizophrenic patients?Jennifer K Johnson
Department of Psychology JKJ, University of California at Los Angeles, Los Angeles, California California 90095 1563, USA
Biol Psychiatry 54:1200-4. 2003Neurocognitive deficits and symptoms of schizotypal personality disorder are both elevated in the first-degree relatives of schizophrenic patients, but their relationship to each other and their potential common genetic source remain ..
- Evaluating the spectrum concept of schizophrenia in the Roscommon Family StudyK S Kendler
Department of Psychiatry, Medical College of Virginia, Richmond 23298 0710, USA
Am J Psychiatry 152:749-54. 1995..The authors sought to evaluate whether the pattern of schizophrenia and related disorders in probands and their relatives can be explained by a single underlying continuum of liability to the "schizophrenia spectrum."..
- Wisconsin Card Sorting Test deficits in schizotypic individualsD C Gooding
Department of Psychology, University of Wisconsin Madison 53706 1696, USA
Schizophr Res 40:201-9. 1999..We identified a subset of schizotypic individuals who also produced clinically deviant WCST profiles. The findings support the hypothesis that executive function deficits may precede the onset of schizophrenia and related illnesses...
- Fronto-temporal disconnectivity in schizotypal personality disorder: a diffusion tensor imaging studyMotoaki Nakamura
Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, MA 02301, USA
Biol Psychiatry 58:468-78. 2005..Here, we investigate these two bundles in unmedicated subjects with schizotypal personality disorder (SPD)...
- Early-onset schizophrenia: a 15-year follow-upBernd Röpcke
Klinik fur Psychiatrie und Psychotherapie des Kindes und Jugendalters, Rheinische Landes und Hochschulklinik Essen, Virchowstrasse 174, 45147 Essen, Germany
Eur Child Adolesc Psychiatry 14:341-50. 2005..Therefore, it seems that VEOS is a special group compared with early onset schizophrenia (EOS) and AOS...
- Neurocognitive deficits in the (putative) prodrome and first episode of psychosisA D Eastvold
University of Utah, USA
Schizophr Res 93:266-77. 2007..The identification of brain based neurocognitive vulnerability markers for schizophrenia may contribute to the development of an at risk algorithm with greater predictive accuracy...
- Psychosis prediction: 12-month follow up of a high-risk ("prodromal") groupAlison R Yung
Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
Schizophr Res 60:21-32. 2003..Symptomatic individuals with either a family history of psychotic disorder, schizotypal personality disorder, subthreshold psychotic symptoms or brief transient psychotic symptoms were assessed and followed up ..
- Neuroprotection: a therapeutic strategy to prevent deterioration associated with schizophreniaJeffrey A Lieberman
Columbia University College of Physicians and Surgeons, New York, NY, USA
CNS Spectr 12:1-13; quiz 14. 2007..Finally, L. Fredrik Jarskog, MD, focuses on the neurobiology of functional progression in schizophrenia as well as pharmacology and the potential for neuroprotection...
- Seeing non-existent events: effects of environmental conditions, schizotypal symptoms, and sub-clinical characteristicsPhil Reed
Institute of Psychiatry, King s College London, Psychological Medicine, 66 Snowsfields, London SE1 3SS, UK
J Behav Ther Exp Psychiatry 39:276-91. 2008..This tendency was especially pronounced in the high schizotypy group. False perceptions were predicted by positive schizotypy and disposition to hallucinations after controlling for trait anxiety, depression and delusional ideation...
- Spatial working memory ability is a marker of risk-for-psychosisS J Wood
Cognitive Neuropsychiatry Research and Academic Unit, PACE Clinic, Department of Psychiatry, University of Melbourne, Sunshine Hospital, St Albans, Vic, Australia
Psychol Med 33:1239-47. 2003..02). CONCLUSIONS: Spatial working memory abilities are impaired in those at high-risk for psychosis. The relationship between working memory and negative symptoms may be useful as a predictive tool...
- Cognitive dysfunctions in parents of schizophrenic patients parallel the deficits found in patientsMelanie C M Appels
Department of Psychiatry, University Medical Center, PO Box 85500, 3508 GA, Utrecht, The Netherlands
Schizophr Res 63:285-93. 2003..e. unilateral motor skill and digit span. Results suggest that the cognitive constructs on which patients show relatively most severe impairment may prove suitable as endophenotypic markers in schizophrenia...
- Patterns of premorbid functioning in first-episode psychosis: initial presentationJean Addington
Department of Psychiatry, University of Calgary, Calgary, AB, Canada
Schizophr Res 62:23-30. 2003....
- Recovery style and outcome in first-episode psychosisKatherine N Thompson
Early Psychosis Prevention and Intervention Centre EPPIC, Australia
Schizophr Res 62:31-6. 2003..The capacity for recovery style to change challenges the suggestion it is a personality trait and raises the need for psychoeducation and other psychological interventions that could improve outcome...
- Prospective study of adolescents with subsyndromal psychosis: characteristics and outcomeChristoph U Correll
The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
J Child Adolesc Psychopharmacol 15:418-33. 2005..The aim of this study was to examine the characteristics and outcome of adolescents with psychotic disorder not otherwise specified (PsyNOS) and brief psychotic disorder (BrPsy), two neglected subsyndromal diagnostic entities...
- PHARMACOLOGY OF COGNITION IN SCHIZOTYPAL PERSONALITYLarry Siever; Fiscal Year: 2003The proposed studies are designed to characterize the cognitive impairment associated with schizotypal personality disorder (SPD) using a cognitive battery including recently developed tests to evaluate the effect of a pharmacologic ..
- Cognitive Control Deficits and Formal Thought DisorderJOHN KERNS; Fiscal Year: 2005..abstract_text> ..
- ANATOMY AND FUNCTION OF THE THALAMUS IN SCHIZOPHRENIAMonte Buchsbaum; Fiscal Year: 2007..41 unmedicated patients with schizophrenia and 60 normal controls and a group of 12 patients with schizotypal personality disorder. This confirmed smaller volumes of the medial dorsal and pulvinar in patients with schizophrenia and ..
- Pharmacology of Cognition in Schizotypal Personality DisorderLarry Siever; Fiscal Year: 2007..study is designed to specifically evaluate: (1) the working memory impairment associated with schizotypal personality disorder (SPD), assessing components of manipulation and maintenance as delineated in Baddeley's comprehensive ..
- VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIAKristin S Cadenhead; Fiscal Year: 2010..The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
- BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDERROBERT MC CARLEY; Fiscal Year: 2007The biological basis of schizotypal personality disorder (SPD) is of intrinsic interest and also important because it bears closely on the nature of schizophrenia (SZ) and "SZ spectrum disorders"...
- BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDERROBERT MC CARLEY; Fiscal Year: 2009The biological basis of schizotypal personality disorder (SPD) is of intrinsic interest and also important because it bears closely on the nature of schizophrenia (SZ) and "SZ spectrum disorders"...
- Pharmacology of Cognition in Schizotypal Personality DisorderLarry J Siever; Fiscal Year: 2010..study is designed to specifically evaluate: (1) the working memory impairment associated with schizotypal personality disorder (SPD), assessing components of manipulation and maintenance as delineated in Baddeley's ..
- BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDERROBERT MC CARLEY; Fiscal Year: 2003..5-year multidisciplinary research study is to advance our understanding of the biological basis of schizotypal personality disorder (SPD), using neuropsychological, electrophysiological, and magnetic resonance imaging (MRI) studies ..
- Prediction of Psychosis in Schizotypal AdolescentsElaine Walker; Fiscal Year: 2006..Findings from our preliminary research indicate that adolescents with schizotypal personality disorder (SPD) manifest several physical indicators that have been observed in schizophrenia patients, ..
- PHARMACOLOGY OF COGNITION IN SCHIZOTYPAL PERSONALITYLarry Siever; Fiscal Year: 2006The proposed studies are designed to characterize the cognitive impairment associated with schizotypal personality disorder (SPD) using a cognitive battery including recently developed tests to evaluate the effect of a pharmacologic ..
- Computational Morphometry in Schizophrenia and Related DisordersSylvain Bouix; Fiscal Year: 2010..including, but not limited to, normal neurodevelopment, Alzheimer's disease, schizophrenia and schizotypal personality disorder (SPD), bipolar disorder, psychotic affective disorder, and fetal alcohol exposure...
- Neural Substrates of Emotion in Borderline PatientsErin Hazlett; Fiscal Year: 2007..Axis I disorder or Cluster A or C personality disorders), 26 non-BPD patients (with a diagnosis of schizotypal personality disorder and no comorbid Cluster B or C personality disorders or Axis I disorder) and 26 healthy controls...
- THE NEURAL CIRCUITRY OF SENSORIMOTOR GATINGErin Hazlett; Fiscal Year: 2002....
- VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIAKristin Cadenhead; Fiscal Year: 2007..The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
- Vulnerability Markers in the Prodrome and First Episode of SchizophreniaKristin Cadenhead; Fiscal Year: 2007....
- VIOLENCE--INTEGRATING SOCIAL AND PHYSIOLOGICAL FACTORSAdrian Raine; Fiscal Year: 2003....
- VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIAKristin Cadenhead; Fiscal Year: 2004..The disruption of social networks, education and occupational activity as well as the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
- 3/3-Improving Metabolic Parameters of Antipsychotic Child Treatment (IMPACT)Christoph U Correll; Fiscal Year: 2010..The results of this project will inform future treatment for children and adolescents with major psychiatric disorders. The results are also likely to lead to treatments that improve their health and longevity. ..
- Anterior Cingulate, Prefrontal Cortex, and Conflict-Control Loop TheoryJOHN KERNS; Fiscal Year: 2006..abstract_text> ..
- Enhancing the Prospective Prediction of PsychosisJean Addington; Fiscal Year: 2007..Each site has proven its ability to recruit prodromal patients in a previous collaboration. ..
- Sensory Processing Deficits in Cannabis UsePATRICK SKOSNIK; Fiscal Year: 2006..Taken together, this data may serve to elucidate whether the known cognitive dysfunction observed in cannabis use is in part related to disturbances in early sensory information processing and/or neural synchronization. ..
- TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIESScott Woods; Fiscal Year: 1999..Nonresponders will be randomized to a study comparing paroxetine with continued CBT. In addition to the main questions, possible predictors of response and relapse will be examined as well as possible mediators of response. ..
- Neurologic Predictors of SchizophreniaJason Schiffman; Fiscal Year: 2007....
- EARLY DETECTION AND INTERVENTION IN PSYCHOSISThomas McGlashan; Fiscal Year: 2003..studies as follows: 4) Ascertaining the frequency, nature, and consequences of prodromal states in Schizotypal Personality Disorder and 5) The epidemiology of prodromal states in first degree relatives of schizophrenic patients in ..
- Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesMatcheri Keshavan; Fiscal Year: 2009....
- Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesMatcheri Keshavan; Fiscal Year: 2007....
- The Effect of Cannabis Use on Human Cerebellar FunctionPATRICK SKOSNIK; Fiscal Year: 2007..Taken together, data from these studies will further our understanding of the cannabinoid system, which will help elucidate the mechanism of action of one of the most commonly used drugs of abuse.Project Narrative ..
- TARDIVE DYSKINESIA INCIDENCE AND ATYPICAL ANTIPSYCHOTICScott Woods; Fiscal Year: 2004..The existence of a previous sample at the same site provides a useful additional comparison group. Methods including sample ascertainment and TD assessment are closely modeled after the original work. ..