schizotypal personality disorder

Summary

Summary: A personality disorder in which there are oddities of thought (magical thinking, paranoid ideation, suspiciousness), perception (illusions, depersonalization), speech (digressive, vague, overelaborate), and behavior (inappropriate affect in social interactions, frequently social isolation) that are not severe enough to characterize schizophrenia.

Top Publications

  1. ncbi Clinical characteristics of first-admitted patients with ICD-10 schizotypal disorder
    Peter Handest
    University Department of Psychiatry, Hvidovre Hospital, Brøndby stervej 160, 2605 Brønby, Denmark
    Br J Psychiatry Suppl 48:s49-54. 2005
  2. ncbi Schizotypal personality: neurodevelopmental and psychosocial trajectories
    Adrian Raine
    Department of Psychology and Neuroscience Program, University of Southern California, Los Angeles, California 90089 1061, USA
    Annu Rev Clin Psychol 2:291-326. 2006
  3. ncbi Anxiety and depression symptoms in psychometrically identified schizotypy
    Kathryn E Lewandowski
    University of North Carolina at Greensboro, Department of Psychology, 296 Eberhart Building, Greensboro, NC 27402, USA
    Schizophr Res 83:225-35. 2006
  4. ncbi Early psychopathological features in Spanish adolescents
    Eduardo Fonseca-Pedrero
    Facultad de Psicologia, Universidad de Oviedo, Oviedo, Spain
    Psicothema 23:87-93. 2011
  5. ncbi Saccadic eye movements, schizotypy, and the role of neuroticism
    Ulrich Ettinger
    Department of Psychology, McGill University, Stewart Biological Sciences Building, 1205 Dr Penfield Ave, Montreal, Que, Canada H3A 1B1
    Biol Psychol 68:61-78. 2005
  6. ncbi Factorial composition of self-rated schizotypal traits among young males undergoing military training
    Nicholas C Stefanis
    Athens University Medical School, Eginition Hospital, 72 74 Vas Sophias Ave, Athens, Greece
    Schizophr Bull 30:335-50. 2004
  7. ncbi Measurement invariance of the Schizotypal Personality Questionnaire-Brief across gender and age
    Eduardo Fonseca-Pedrero
    Department of Psychology, University of Oviedo, Spain
    Psychiatry Res 190:309-15. 2011
  8. pmc Auditory steady state response in the schizophrenia, first-degree relatives, and schizotypal personality disorder
    Olga Rass
    Department of Psychological and Brain Sciences, Indiana University, 1101 East 10th Street, Bloomington, IN 47405, USA
    Schizophr Res 136:143-9. 2012
  9. ncbi Confirmation of a four-factor structure of the Schizotypal Personality Questionnaire among undergraduate students
    Michael T Compton
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, Georgia 30322, USA
    Schizophr Res 111:46-52. 2009
  10. ncbi Overlap of autistic and schizotypal traits in adolescents with Autism Spectrum Disorders
    Petra S Barneveld
    Leiden University, Department of Clinical Child and Adolescent Studies, PO Box 9555, 2300 RB Leiden, The Netherlands
    Schizophr Res 126:231-6. 2011

Detail Information

Publications277 found, 100 shown here

  1. ncbi Clinical characteristics of first-admitted patients with ICD-10 schizotypal disorder
    Peter Handest
    University Department of Psychiatry, Hvidovre Hospital, Brøndby stervej 160, 2605 Brønby, Denmark
    Br J Psychiatry Suppl 48:s49-54. 2005
    ..The clinical picture of schizotypal disorders is rarely comprehensively described...
  2. ncbi Schizotypal personality: neurodevelopmental and psychosocial trajectories
    Adrian Raine
    Department of Psychology and Neuroscience Program, University of Southern California, Los Angeles, California 90089 1061, USA
    Annu Rev Clin Psychol 2:291-326. 2006
    ....
  3. ncbi Anxiety and depression symptoms in psychometrically identified schizotypy
    Kathryn E Lewandowski
    University of North Carolina at Greensboro, Department of Psychology, 296 Eberhart Building, Greensboro, NC 27402, USA
    Schizophr Res 83:225-35. 2006
    ....
  4. ncbi Early psychopathological features in Spanish adolescents
    Eduardo Fonseca-Pedrero
    Facultad de Psicologia, Universidad de Oviedo, Oviedo, Spain
    Psicothema 23:87-93. 2011
    ..These results are convergent with previous studies conducted in both clinical and non-clinical samples, indicating overlap between schizotypal experiences and depressive symptoms...
  5. ncbi Saccadic eye movements, schizotypy, and the role of neuroticism
    Ulrich Ettinger
    Department of Psychology, McGill University, Stewart Biological Sciences Building, 1205 Dr Penfield Ave, Montreal, Que, Canada H3A 1B1
    Biol Psychol 68:61-78. 2005
    ..We conclude that saccadic performance patterns in schizotypy are not due to negative emotionality or general psychopathology, but specific to schizophrenia spectrum signs and symptoms...
  6. ncbi Factorial composition of self-rated schizotypal traits among young males undergoing military training
    Nicholas C Stefanis
    Athens University Medical School, Eginition Hospital, 72 74 Vas Sophias Ave, Athens, Greece
    Schizophr Bull 30:335-50. 2004
    ..self-rated Schizotypal Personality Questionnaire (SPQ), which covers all nine aspects of DSM-III-R schizotypal personality disorder (SPD)...
  7. ncbi Measurement invariance of the Schizotypal Personality Questionnaire-Brief across gender and age
    Eduardo Fonseca-Pedrero
    Department of Psychology, University of Oviedo, Spain
    Psychiatry Res 190:309-15. 2011
    ....
  8. pmc Auditory steady state response in the schizophrenia, first-degree relatives, and schizotypal personality disorder
    Olga Rass
    Department of Psychological and Brain Sciences, Indiana University, 1101 East 10th Street, Bloomington, IN 47405, USA
    Schizophr Res 136:143-9. 2012
    ..The sensitivity of the 40 Hz ASSR to schizophrenia spectrum phenotypes, such as schizotypal personality disorder (SPD), or to familial risk has been less well characterized...
  9. ncbi Confirmation of a four-factor structure of the Schizotypal Personality Questionnaire among undergraduate students
    Michael T Compton
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, Georgia 30322, USA
    Schizophr Res 111:46-52. 2009
    ..This study determined the best-fitting factor structure from among five models that have been proposed in the literature, as well as five additional hierarchically related models...
  10. ncbi Overlap of autistic and schizotypal traits in adolescents with Autism Spectrum Disorders
    Petra S Barneveld
    Leiden University, Department of Clinical Child and Adolescent Studies, PO Box 9555, 2300 RB Leiden, The Netherlands
    Schizophr Res 126:231-6. 2011
    ....
  11. ncbi Effect of COMT val158met genotype on cognition and personality
    A J Sheldrick
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Eur Psychiatry 23:385-9. 2008
    ..Furthermore, we replicated findings from a recent study whereby the COMT genotype also predicts disorganized personality features...
  12. pmc Looking at the schizophrenia spectrum through the prism of self-disorders: an empirical study
    Andrea Raballo
    Danish National Research Foundation Center for Subjectivity Research, University of Copenhagen, Copenhagen S, Denmark
    Schizophr Bull 37:344-51. 2011
    ..Manual of Mental Disorders (Third Edition Revised) main diagnosis: schizophrenia, (n = 29), schizotypal personality disorder (n = 61), other mental illness not belonging to the schizophrenia spectrum (n = 112), and no mental ..
  13. pmc Fronto-temporal disconnectivity in schizotypal personality disorder: a diffusion tensor imaging study
    Motoaki Nakamura
    Clinical Neuroscience Division, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, MA 02301, USA
    Biol Psychiatry 58:468-78. 2005
    ..Here, we investigate these two bundles in unmedicated subjects with schizotypal personality disorder (SPD).
  14. ncbi Effect of age and gender on schizotypal personality traits in the normal population
    Emre Bora
    Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Victoria, Australia
    Psychiatry Clin Neurosci 63:663-9. 2009
    ..One important limitation of previous studies, however, is the restricted age range of subjects. The aim of the present study was therefore to investigate the effect of gender and age on schizotypal personality features...
  15. ncbi Validation of the Schizotypal Personality Questionnaire-Brief Form in adolescents
    Eduardo Fonseca-Pedrero
    University of Oviedo, Department of Psychology, Spain
    Schizophr Res 111:53-60. 2009
    ....
  16. ncbi The multidimensionality of self-report schizotypy in a psychiatric population: an analysis using multidimensional Rasch models
    M G Vollema
    Meerkanten GGZ Felvo Veluwe, Veldwijk Psychiatric Hospital Dept of Psychological Assessment, Ermelo, The Netherlands
    Schizophr Bull 26:565-75. 2000
    ..1994) and Gruzelier (1996), yielded the best fit. It consisted of positive schizotypy, disorganization, and negative schizotypy. The results strongly suggest that schizotypy, as measured with the SPQ, is a three-dimensional construct...
  17. ncbi Sustained attention deficit along the psychosis proneness continuum: a study on the Sustained Attention to Response Task (SART)
    Raymond C K Chan
    Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
    Cogn Behav Neurol 22:180-5. 2009
    ..Sustained attention deficits have been associated with schizophrenia. However, these findings were limited to patients with schizophrenia and cannot be generalized to a wider nonclinical sample with schizotypal personality features...
  18. ncbi Toward a more psychometrically sound brief measure of schizotypal traits: introducing the SPQ-Brief Revised
    Alex S Cohen
    Louisiana State University, 236 Audubon Hall, Baton Rouge, LA 70808, USA
    J Pers Disord 24:516-37. 2010
    ..The end product of these studies is the SPQ-Brief Revised, which offers a subordinate seven-factor and super-ordinate three or four factor solution, employs a Likert-scale format to improve sensitivity, and is brief (34 items)...
  19. ncbi Does the Schizotypal Personality Questionnaire reflect the biological-genetic vulnerability to schizophrenia?
    M G Vollema
    Meerkanten GGZ Flevo Veluwe, P O Box 1000, 3850 BA Ermelo, The Netherlands
    Schizophr Res 54:39-45. 2002
    ..Children scored higher than parents on Negative Schizotypy. The current study offers support to the hypothesis that the positive dimension of SPQ reflects the genetic vulnerability to schizophrenia...
  20. ncbi Effect of schizotypy on cognitive performance and its tuning by COMT val158 met genotype variations in a large population of young men
    Nikolaos Smyrnis
    University Mental Health Research Institute, Psychiatry Department, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece
    Biol Psychiatry 61:845-53. 2007
    ..The relation of schizotypy and state psychopathology to cognitive performance and its link to catechol-O-methyltransferase (COMT) val(158) met genotype variations was studied in a large sample of young men...
  21. ncbi Cluster A maladaptive personality patterns in a non-clinical adolescent population
    Eduardo Fonseca-Pedrero
    Departamento de Ciencias de la Educacion, Universidad de La Rioja, 26002 Logroño, Spain
    Psicothema 25:171-8. 2013
    ..In addition, the underlying dimensional structure and the possible influence of sex and age in its phenotypic expression were examined...
  22. ncbi Hand-preference and population schizotypy: a meta-analysis
    M Somers
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, B01 206, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Schizophr Res 108:25-32. 2009
    ..Bilateral language organisation may underlie loosening of association, possibly leading to higher schizotypy scores...
  23. ncbi A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population
    Xiaohong Ma
    Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China
    Psychiatry Res 153:7-15. 2007
    ..Molecular Psychiatry 7, 706-711]. We conclude that SNP Val158Met (rs4680) in the COMT gene may be associated with some schizotypal traits in male subjects, but our results are not conclusive...
  24. ncbi Prospective memory deficits in subjects with schizophrenia spectrum disorders: a comparison study with schizophrenic subjects, psychometrically defined schizotypal subjects, and healthy controls
    Ya Wang
    Department of Psychology, Sun Yat Sen University, Guangzhou, China School of Life Science, Sun Yat Sen University, Guangzhou, China
    Schizophr Res 106:70-80. 2008
    ..It is suggested that prospective memory be considered a potential endophenotype of schizophrenia...
  25. ncbi Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity allele
    Franck Schurhoff
    Département Hospitalo Universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor, 40 rue Mesly, Creteil, France
    Am J Med Genet B Neuropsychiatr Genet 144:64-8. 2007
    ....
  26. ncbi Sustained attention deficits in relation to psychometrically identified schizotypy: evaluating a potential endophenotypic marker
    Diane C Gooding
    University of Wisconsin Madison, Department of Psychology, Madison, WI 53706, USA
    Schizophr Res 82:27-37. 2006
    ..The findings add to the converging evidence indicating that sustained attention deficits are a potential endophenotypic indicator of a schizophrenia diathesis...
  27. pmc Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk?
    Alison R Yung
    ORYGEN Research Centre, 35 Poplar Road, Parkville 3052, Victoria, Australia
    Schizophr Bull 33:673-81. 2007
    ..Patients presenting to them need help. It may be that we need to aim to prevent a range of target syndromes...
  28. ncbi Temporal lobe volume determined by magnetic resonance imaging in schizotypal personality disorder and schizophrenia
    J E Downhill
    Department of Psychiatry, Neuroscience PET Lab, Box 1505, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574, USA
    Schizophr Res 48:187-99. 2001
    ..gyrus and the corpus callosum were measured on magnetic resonance images from 13 patients with schizotypal personality disorder (SPD), 27 patients with schizophrenia, and 31 age- and sex-matched controls...
  29. ncbi Emotional correlates of the different dimensions of schizotypal personality disorder
    Howard Berenbaum
    Department of Psychology, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    J Abnorm Psychol 115:359-68. 2006
    Two studies explored which different dimensions of schizotypal personality disorder (SPD) were associated with negative affect, attention to emotions, clarity of emotions, and emotional intensity/instability...
  30. ncbi Schizotypy facets, cognitive control, and emotion
    John G Kerns
    Department of Psychological Sciences, University of Missouri Columbia, 65211, USA
    J Abnorm Psychol 115:418-27. 2006
    ....
  31. pmc Empathy, schizotypy, and visuospatial transformations
    Katharine N Thakkar
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Cogn Neuropsychiatry 15:477-500. 2010
    ..In the current study, we sought to explore the relationship between empathy, schizotypy, and visuospatial transformation ability...
  32. ncbi Objective measures of prospective memory do not correlate with subjective complaints in schizophrenia
    Raymond C K Chan
    Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    Schizophr Res 103:229-39. 2008
    ..poorer performance in all domains of memory function except visual memory than individuals with schizotypal personality disorder and healthy controls...
  33. pmc Emotion processing in persons at risk for schizophrenia
    Laura K Phillips
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Schizophr Bull 34:888-903. 2008
    ..The most robust findings in at-risk groups are in the areas of reduced emotion perception, self-reported anhedonia, and increased negative affect. We conclude with an agenda for future research...
  34. ncbi The relationship of Asperger's characteristics and schizotypal personality traits in a non-clinical adult sample
    Ruth M Hurst
    University of North Carolina at Greensboro, Greensboro, NC, USA
    J Autism Dev Disord 37:1711-20. 2007
    The study examines the relationship between Asperger's Disorder (AD) and Schizotypal Personality Disorder (SPD), mutually exclusive but similar diagnoses [DSM-IV-TR; American Psychiatric Association (2000)...
  35. ncbi Schizotypy in community samples: the three-factor structure and correlation with sustained attention
    W J Chen
    Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei
    J Abnorm Psychol 106:649-54. 1997
    ..The PAS differed from the Cognitive-Perceptual factor in its consistent association with poorer attention in both samples. These have important implications for the scales in the early detection of the schizotypy in various cultures...
  36. pmc Temperament and character as schizophrenia-related endophenotypes in non-psychotic siblings
    Matthew J Smith
    Northwestern University, Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL 60611, United States
    Schizophr Res 104:198-205. 2008
    ..Thus, measures of temperament and character may serve as schizophrenia-related endophenotypes in individuals with schizophrenia and their non-psychotic siblings...
  37. ncbi Mentalising, schizotypy, and schizophrenia
    R Langdon
    Department of Psychology, Macquarie University, Sydney, NSW, Australia
    Cognition 71:43-71. 1999
    ....
  38. ncbi Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Brain 128:2109-22. 2005
    ....
  39. ncbi Social anhedonia as a predictor of the development of schizophrenia-spectrum disorders
    T R Kwapil
    Department of Psychology, University of Wisconsin, Madison, USA
    J Abnorm Psychol 107:558-65. 1998
    ..Thus, the SocAnh Scale, unlike the Perceptual Aberration and Magical Ideation Scales, appears to identify individuals at specific risk for future development of schizophrenia-spectrum disorders...
  40. ncbi Hedonic capacity and schizotypy revisited: a taxometric analysis of social anhedonia
    J J Blanchard
    Department of Psychology, University of New Mexico, USA
    J Abnorm Psychol 109:87-95. 2000
    ..10. These data are interpreted in the context of other findings suggesting that social anhedonia is an indicator of schizotypy...
  41. ncbi Multiple dimensions of schizotypy in first degree biological relatives of schizophrenia patients
    Monica E Calkins
    University of Pennsylvania School of Medicine, Neuropsychiatry Section, Schizophrenia Research Center, Pittsburgh, PA, USA
    Schizophr Bull 30:317-25. 2004
    ....
  42. ncbi A follow-up MRI study of the superior temporal subregions in schizotypal disorder and first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 119:65-74. 2010
    ....
  43. ncbi Magnetic resonance imaging of the thalamic mediodorsal nucleus and pulvinar in schizophrenia and schizotypal personality disorder
    W Byne
    Mount Sinai School of Medicine, New York, NY, USA
    Arch Gen Psychiatry 58:133-40. 2001
    ..Because frontal and temporal lobe volumes are diminished in schizophrenia, volume loss could characterize their primary thalamic relay nuclei (mediodorsal nucleus [MDN] and pulvinar)...
  44. ncbi Perceptual aberrations impair mental own-body transformations
    C Mohr
    Department of Experimental Psychology, University of Bristol, Bristol, United Kingdom
    Behav Neurosci 120:528-34. 2006
    ....
  45. ncbi Minor physical anomalies, dermatoglyphic asymmetries, and cortisol levels in adolescents with schizotypal personality disorder
    D D Weinstein
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Am J Psychiatry 156:617-23. 1999
    A relationship between schizotypal personality disorder and schizophrenia has been documented in behavioral genetic studies, and there are similarities in the cognitive deficits and brain abnormalities associated with these disorders...
  46. pmc Prodromal symptoms in adolescents with 22q11.2 deletion syndrome and schizotypal personality disorder
    D I Shapiro
    Emory University, Department of Psychology, GA, 30324, USA
    Schizophr Res 129:20-8. 2011
    Adolescents with 22q11.2 Deletion Syndrome (22q11.2DS) and Schizotypal Personality Disorder (SPD) are at increased risk for the development of psychosis based, respectively, on genetic or behavioral factors...
  47. ncbi Reduced Kamin blocking in non paranoid schizophrenia: associations with schizotypy
    P M Moran
    School of Psychology, University of Leicester, University Road, Leicester LE1 7RH, UK
    J Psychiatr Res 37:155-63. 2003
    ....
  48. ncbi Handedness and schizotypy in non-clinical populations: influence of handedness measures and age on the relationship
    Wei J Chen
    National Taiwan University College of Public Health, Taiwan
    Laterality 11:331-49. 2006
    ..The results highlight the potential of adolescents for future investigation on certain common causes underlying atypical cerebral lateralisation and positive schizotypy...
  49. pmc Experience of pleasure and emotional expression in individuals with schizotypal personality features
    Yan fang Shi
    Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 7:e34147. 2012
    ..of pleasure and emotional expression in college students who demonstrated high and low levels of schizotypal personality disorder (SPD) traits on self-report questionnaires...
  50. ncbi Semantic processing impairment in individuals with schizotypal personality disorder features: a preliminary event-related potential study
    Kui Wang
    Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    Prog Neuropsychopharmacol Biol Psychiatry 40:93-102. 2013
    This study aimed to examine semantic processing features in individuals with and without schizotypal personality disorder (SPD) features.
  51. pmc Social functioning in Chinese college students with and without schizotypal personality traits: an exploratory study of the Chinese version of the First Episode Social Functioning Scale
    Yi Wang
    Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 8:e61115. 2013
    ..The First Episode Social Functioning Scale (FESFS) was designed to measure social functioning of young individuals with schizophrenia. The aim of this study was to validate a Chinese version of the FESFS in a sample of young Chinese adults...
  52. ncbi Empathy, social functioning and schizotypy
    Julie D Henry
    School of Psychology, University of New South Wales, Sydney, Australia
    Psychiatry Res 160:15-22. 2008
    ..These data show that the relationship between negative schizotypy and social functioning is at least partially attributable to deficits in affective empathy...
  53. ncbi Endophenotyping schizotypy: a prelude to genetic studies within the schizophrenia spectrum
    Kristin S Cadenhead
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Schizophr Res 54:47-57. 2002
    Schizophrenia is a complex genetic disease with a prevalence rate of 1% in the general population. Schizotypal personality disorder (SPD) occurs in up to 3% of the population, and these subjects are phenomenologically and perhaps ..
  54. ncbi Structural brain differences in patients with schizophrenia and schizotypal disorder demonstrated by voxel-based morphometry
    Yasuhiro Kawasaki
    Dept of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur Arch Psychiatry Clin Neurosci 254:406-14. 2004
    ....
  55. ncbi Schizotypy and the shift from dextrality: a study of handedness in a large non-clinical sample
    J Shaw
    Department of Experimental Psychology, University of Oxford, South Parks Road, OX1 3UD, Oxford, UK
    Schizophr Res 50:181-9. 2001
    ..These findings are discussed in the light of various possible explanations of the association between handedness and schizophrenia/schizotypy...
  56. ncbi Neuropsychological performance in schizotypal personality disorder: importance of working memory
    Vivian Mitropoulou
    Clinical Research Center, Box 1027, Mt Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Am J Psychiatry 162:1896-903. 2005
    Cognitive deficits consistently have been reported in schizophrenia patients and in patients with schizotypal personality disorder. For this study, the authors wanted to identify which of the domains of cognitive impairment represent "..
  57. pmc Auditory processing abnormalities in schizotypal personality disorder: an fMRI experiment using tones of deviant pitch and duration
    Chandlee C Dickey
    Serious Mental Illness Program, VA Boston Healthcare System, Psychiatry 116A RC, 940 Belmont St, Brockton, MA 02401, United States
    Schizophr Res 103:26-39. 2008
    One of the cardinal features of schizotypal personality disorder (SPD) is language abnormalities...
  58. ncbi Schizotypy and mixed-handedness revisited
    Milan Dragovic
    Centre for Clinical Research in Neuropsychiatry, University of Western Australia, Perth, Australia
    Psychiatry Res 136:143-52. 2005
    ..In contrast, there was an expected significant but low in magnitude association between loss of hand dominance and the Schizotypal Personality Questionnaire factor of Cognitive Perceptual Dysfunction in schizophrenia patients...
  59. ncbi Going beyond students: an association between mixed-hand preference and schizotypy subscales in a general population
    Heidi L Chapman
    School of Psychology, The University of Birmingham, Birmingham, UK
    Psychiatry Res 187:89-93. 2011
    ..The possibility that the association is related to response biases or a biological mechanism is discussed...
  60. ncbi Elevated levels of schizotypal features in parents of patients with a family history of schizophrenia spectrum disorders
    Melanie C M Appels
    Cognitive Neuroscience Unit, University Medical Center Utrecht, The Netherlands
    Schizophr Bull 30:781-90. 2004
    ....
  61. ncbi Magical ideation and its relation to lateral preference
    Michael E R Nicholls
    Department of Psychology, University of Melbourne, Vic, Australia
    Laterality 10:503-15. 2005
    ..The results support research linking schizotypal personality to ambidextrality and weak cerebral dominance and demonstrate that the association extends to modalities other than hand preference...
  62. ncbi Exploratory study on the base-rate of paranoid ideation in a non-clinical Chinese sample
    Raymond C K Chan
    Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    Psychiatry Res 185:254-60. 2011
    ..Participants were classified into individuals with and without schizotypal personality disorder (SPD) features based on the SPQ. For the frequency subscale, 2.1-18...
  63. pmc Dorso- and ventro-lateral prefrontal volume and spatial working memory in schizotypal personality disorder
    Kim E Goldstein
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Behav Brain Res 218:335-40. 2011
    b>Schizotypal personality disorder (SPD) individuals and borderline personality disorder (BPD) individuals have been reported to show neuropsychological impairments and abnormalities in brain structure...
  64. ncbi Abnormal pitch mismatch negativity in individuals with schizotypal personality disorder
    Margaret A Niznikiewicz
    VA Boston Healthcare System Boston VA Healthcare System, Jamaica Plain VA and Brockton VA campuses, United States
    Schizophr Res 110:188-93. 2009
    The goal of the study was to examine mismatch negativity (MMN) in schizotypal personality disorder (SPD) individuals...
  65. ncbi The role of intellectual openness in the relationship between hand preference and positive schizotypy
    Frances M Bryson
    Victoria University of Wellington, New Zealand
    Laterality 14:441-56. 2009
    ..These findings suggest that responses on handedness questionnaires partially reflect personality variables, and such effects should be considered in future research on the nature of the relationship between handedness and schizotypy...
  66. ncbi Gray matter features of schizotypal disorder patients exhibiting the schizophrenia-related code types of the Minnesota Multiphasic Personality Inventory
    E Yoneyama
    Department of Neuropsychiatry, School of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Acta Psychiatr Scand 108:333-40. 2003
    ..We hypothesized that schizotypal disorder (STD) patients with such schizophrenia-related code types have the morphological brain abnormalities associated with schizophrenia...
  67. ncbi Schizotypal personality disorder inside and outside the schizophrenic spectrum
    Svenn Torgersen
    Department of Psychology, Center for Research in Clinical Psychology, Oslo University, PO Box 1039, Blindern, N 0315 Oslo, Norway
    Schizophr Res 54:33-8. 2002
    The concept of schizotypal personality disorder has been heavily discussed since its introduction into the official classification of mental disorders in DSM-III...
  68. pmc Clinical, cognitive, and social characteristics of a sample of neuroleptic-naive persons with schizotypal personality disorder
    Chandlee C Dickey
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Psychiatry 116A, 940 Belmont St, Brockton, MA 02401, USA
    Schizophr Res 78:297-308. 2005
    b>Schizotypal personality disorder (SPD) shares with schizophrenia many biological features, yet little is known about the clinical characteristics of persons diagnosed with this disorder...
  69. ncbi Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorder
    Min Seong Koo
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Arch Gen Psychiatry 63:1090-100. 2006
    Structural brain abnormalities, including larger cerebrospinal fluid (CSF) volumes, have been observed in men diagnosed as having schizotypal personality disorder (SPD).
  70. pmc Factors in sensory processing of prosody in schizotypal personality disorder: an fMRI experiment
    Chandlee C Dickey
    Serious Mental Illness Program, VA Boston Healthcare System, Psychiatry 116A 7, 940 Belmont St, Brockton, MA 02301, United States
    Schizophr Res 121:75-89. 2010
    ..To examine prosody along the schizophrenia spectrum, antipsychotic-naïve schizotypal personality disorder (SPD) subjects and healthy control subjects were compared...
  71. ncbi Topographic abnormalities of P3 in schizotypal personality disorder
    D F Salisbury
    Harvard Medical School, Department of Psychiatry at Massachusetts Mental Health Center, Boston, USA
    Biol Psychiatry 40:165-72. 1996
    ..Asymmetry of P3 amplitude, with left-sided deficit, may be associated with the schizophrenia diathesis, but overall P3 reductions may be more associated with chronic effects...
  72. ncbi Cannabis use is associated with schizotypy and attentional disinhibition
    P D Skosnik
    Department of Psychology, Northwestern University, Evanston, IL 60208, USA
    Schizophr Res 48:83-92. 2001
    ..These results suggest that cannabis use can mimic attentional deficits seen in acute schizophrenia and is associated with schizotypal personality, thus setting the stage for a possible cannabinoid model of SZ...
  73. pmc An MRI study of superior temporal gyrus volume in women with schizotypal personality disorder
    Chandlee C Dickey
    VA Boston Healthcare System, Psychiatry 116A, 940 Belmont St, Brockton, MA 02401, USA
    Am J Psychiatry 160:2198-201. 2003
    ..research, and left superior temporal gyrus volume has been shown to be smaller in male subjects with schizotypal personality disorder. This is the first structural magnetic resonance imaging study to examine a group of female subjects ..
  74. ncbi Visual event-related potentials in schizotypal personality disorder and schizophrenia
    Jenifer L Vohs
    Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN 47405, USA
    J Abnorm Psychol 117:119-31. 2008
    Schizophrenia (SZ) occurs among a spectrum of disorders with similar characteristics, including schizotypal personality disorder (SPD)...
  75. ncbi Volume reduction of the right anterior limb of the internal capsule in patients with schizotypal disorder
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 130:213-25. 2004
    ..Volume deficit confined to the right ALIC suggests that limited involvement of the fronto-thalamic connectivity may have some relevance to the sparing of schizotypal patients from the development of overt psychosis...
  76. pmc MRI abnormalities of the hippocampus and cavum septi pellucidi in females with schizotypal personality disorder
    Chandlee C Dickey
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA
    Schizophr Res 89:49-58. 2007
    This study examined MRI hippocampal volume and cavum septi pellucidi (CSP) in female subjects with schizotypal personality disorder (SPD) and comparison subjects.
  77. pmc The five-factor model in schizotypal personality disorder
    Ronald J Gurrera
    Harvard Medical School, Department of Psychiatry, Boston, MA, USA
    Schizophr Res 80:243-51. 2005
    Studies of the five-factor model of personality in schizotypal personality disorder (SPD) have produced inconsistent results, particularly with respect to openness...
  78. ncbi Cingulate gyrus volume and metabolism in the schizophrenia spectrum
    M Mehmet Haznedar
    Department of Psychiatry, Mount Sinai School of Medicine, Neuroscience PET Laboratory, One Gustave L Levy Place, P O Box 1505, New York, NY 10029 6574, USA
    Schizophr Res 71:249-62. 2004
    ....
  79. pmc The uncinate fasciculus and extraversion in schizotypal personality disorder: a diffusion tensor imaging study
    Ronald J Gurrera
    Schizophr Res 90:360-2. 2007
  80. ncbi The effects of guanfacine on context processing abnormalities in schizotypal personality disorder
    Margaret M McClure
    VA VISN3 Mental Illness Research, Education, and Clinical Center, Bronx, New York 10468, USA
    Biol Psychiatry 61:1157-60. 2007
    The signature of impaired cognition in people with schizotypal personality disorder (SPD) may be centrally related to working memory impairments...
  81. ncbi Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorder
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur Arch Psychiatry Clin Neurosci 252:268-77. 2002
    ..These results suggest that both schizotypal and schizophrenic subjects share, at least in part, the same cerebral asymmetry abnormalities...
  82. ncbi Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene
    Yuka Yasuda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurosci Lett 495:216-20. 2011
    ..an increased risk not only for schizophrenia but also for schizophrenia spectrum disorders, such as schizotypal personality disorder. A single nucleotide polymorphism (SNP), rs1344706, in the Zinc Finger Protein 804A (ZNF804A) gene, ..
  83. pmc Heritability and longitudinal stability of schizotypal traits during adolescence
    Marissa Ericson
    Department of Psychology SGM 501, University of Southern California, Los Angeles, CA 90089 1061, USA
    Behav Genet 41:499-511. 2011
    ....
  84. pmc Smaller left Heschl's gyrus volume in patients with schizotypal personality disorder
    Chandlee C Dickey
    Harvard Medical School, Clinical Neuroscience Division, Department of Psychiatry, VA Boston Healthcare System, Brockton, MA 02401, USA
    Am J Psychiatry 159:1521-7. 2002
    ..Magnetic resonance imaging (MRI) studies have shown smaller gray matter volume in patients with schizotypal personality disorder than in matched comparison subjects in the left superior temporal gyrus, an area important for ..
  85. ncbi Schizotypal traits and cognitive function in healthy adults
    Hiroko Noguchi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Psychiatry Res 161:162-9. 2008
    ....
  86. ncbi Emotion dysregulation and schizotypy
    Julie D Henry
    School of Psychology, University of New South Wales, Sydney, NSW 2052 Australia
    Psychiatry Res 166:116-24. 2009
    ..Implications for understanding blunted affect in schizophrenia and related disorders are discussed...
  87. pmc The brain in schizotypal personality disorder: a review of structural MRI and CT findings
    Chandlee C Dickey
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Boston, MA 02401, USA
    Harv Rev Psychiatry 10:1-15. 2002
    Studies of schizotypal personality disorder (SPD) are important because the condition is genetically related to schizophrenia and because data accumulating to confirm its biological underpinnings are challenging some traditional views ..
  88. pmc Cingulate and temporal lobe fractional anisotropy in schizotypal personality disorder
    Erin A Hazlett
    Mental Illness Research, Education and Clinical Center VISN 3, James J Peters Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Neuroimage 55:900-8. 2011
    Consistent with the clinical picture of milder symptomatology in schizotypal personality disorder (SPD) than schizophrenia, morphological studies indicate SPD abnormalities in temporal lobe regions but to a much lesser extent in ..
  89. pmc Shape abnormalities of caudate nucleus in schizotypal personality disorder
    James J Levitt
    Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, USA
    Schizophr Res 110:127-39. 2009
    Previously, we reported abnormal volume and global shape in the caudate nucleus in schizotypal personality disorder (SPD)...
  90. ncbi Prefrontal structural and functional deficits in schizotypal personality disorder
    Adrian Raine
    Department of Psychology, University of Southern California, Los Angeles, CA 90089 1061, USA
    Schizophr Bull 28:501-13. 2002
    ....
  91. ncbi Neurocognitive, behavioural and neurodevelopmental correlates of schizotypy clusters in adolescents from the general population
    Neus Barrantes-Vidal
    Departament de Psicologia de la Salut, Facultat de Psicologia, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Schizophr Res 61:293-302. 2003
    ..We aimed to establish clusters of normal adolescents based on schizotypy dimensions and compare them on neurocognitive, behavioural, and neurodevelopmental markers...
  92. pmc Increased temporal variability of auditory event-related potentials in schizophrenia and Schizotypal Personality Disorder
    Yong Wook Shin
    Department of Psychological and Brain Sciences, Indiana University, 1101 E 10th Street, Bloomington, IN 47405, United States
    Schizophr Res 124:110-8. 2010
    ..Synchronization or timing abnormalities may represent a biomarker for schizophrenia spectrum disorders, and contribute to aberrant perceptual and cognitive integration...
  93. ncbi Executive/attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relatives
    A Laurent
    Department of Psychiatry, University Hospital of Grenoble, BP 217 38043, Grenoble, France
    Schizophr Res 46:269-83. 2000
    ..Only two significant correlations were found between the neuropsychological performance and the measures of schizotypy...
  94. ncbi Primary and secondary hypohedonia
    P E Meehl
    Department of Psychology, University of Minnesota, Elliott Hall, 75 East River Road, Minneapolis, Minnesota 55455-0344, USA
    J Abnorm Psychol 110:188-93. 2001
    ..To choose between causal interpretations, it could be ascertained whether the schizotypal anhedonic taxon is composed of individuals who are schizotaxic on the basis of psychophysiological, cognitive, and soft neurologic indicators...
  95. ncbi Differential metabolic rates in prefrontal and temporal Brodmann areas in schizophrenia and schizotypal personality disorder
    Monte S Buchsbaum
    Neuroscience PET Laboratory, Department of Psychiatry, Mt Sinai School of Medicine, Box 1505, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Schizophr Res 54:141-50. 2002
    ..spectrum, we compared cortical metabolic rates in unmedicated patients with schizophrenia and schizotypal personality disorder (SPD) with findings in age- and sex-matched normal volunteers...
  96. ncbi Concurrent validation of schizotaxia: a pilot study
    W S Stone
    Department of Psychiatry at Massachusetts Mental Health Center, Harvard Medical School, 74 Fenwood Road, Boston, MA 02115, USA
    Biol Psychiatry 50:434-40. 2001
    ....
  97. pmc The empirical status of the ultra high-risk (prodromal) research paradigm
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, CA, USA
    Schizophr Bull 33:661-4. 2007
    ....
  98. ncbi Regional cerebral blood flow during the Wisconsin Card Sort Test in schizotypal personality disorder
    M S Buchsbaum
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Schizophr Res 27:21-8. 1997
    ..blood flow (rCBF) was measured by single photon emission computed tomography in 10 patients with schizotypal personality disorder (SPD) and nine age- and sex-matched normal volunteers...
  99. ncbi Pre-morbid psychopathology in schizophrenia spectrum
    J Parnas
    University Department of Psychiatry, Kommunehospitalet, Copenhagen, Denmark
    Br J Psychiatry 155:623-7. 1989
    ..Pre-schizophrenics', as compared with 'pre-schizotypes', were characterised by affective dyscontrol, reflected in less introverted and more disturbed behaviour...
  100. ncbi Risperidone in the treatment of schizotypal personality disorder
    Harold W Koenigsberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10468, USA
    J Clin Psychiatry 64:628-34. 2003
    b>Schizotypal personality disorder (SPD) has many phenomenological, genetic, physiologic, and neuroanatomical commonalities with schizophrenia...
  101. pmc A qualitative research study of the evolution of symptoms in individuals identified as prodromal to psychosis
    Cheryl Corcoran
    New York State Psychiatric Institute Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Psychiatr Q 74:313-32. 2003
    ..Although preliminary, these results suggest that a trajectory of change in personality, relationships, and behavior from an essentially normal baseline may be consistent with increased risk for psychosis among prodromal adolescents...

Research Grants62

  1. Cognitive Control Deficits and Formal Thought Disorder
    JOHN KERNS; Fiscal Year: 2005
    ..abstract_text> ..
  2. VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIA
    Kristin S Cadenhead; Fiscal Year: 2010
    ..The disruption of social networks, education and occupational activity and the high incidence of suicide and crime that often accompany psychosis might be reduced or averted. ..
  3. A D1 Agonist for Working Memory Enhancement in the Schizophrenia Spectrum
    Larry J Siever; Fiscal Year: 2013
    ..selective, full, dopamine-1 receptor (D1R) agonist -- on working memory impairments in patients with schizotypal personality disorder (SPD)...
  4. White Matter Abnormalities in the Schizophrenia Spectrum
    Larry J Siever; Fiscal Year: 2013
    ..We have selected schizotypal personality disorder (SPD) subjects as our choice of phenotype as they represent a form of schizophrenia without the ..
  5. Schizophrenia biomarkers discerned by cellular networks in DiGeorge syndrome
    Bradley D Pearce; Fiscal Year: 2010
    ..g. schizotypal personality disorder), or subtypes of the disorder...
  6. Computational Morphometry in Schizophrenia and Related Disorders
    Sylvain Bouix; Fiscal Year: 2013
    ..including, but not limited to, normal neurodevelopment, Alzheimer's disease, schizophrenia and schizotypal personality disorder (SPD), bipolar disorder, psychotic affective disorder, and fetal alcohol exposure...
  7. Cerebellar dysfunction in schizophrenia
    William P Hetrick; Fiscal Year: 2013
    ..Moreover, we found that 1st-degree relatives of SZ patients and individuals with schizotypal personality disorder also exhibit associative learning deficits...
  8. BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDER
    ROBERT MC CARLEY; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The biological basis of schizotypal personality disorder (SPD) is of intrinsic interest and also important because it bears closely on the nature of schizophrenia (SZ) and "SZ spectrum disorders"...
  9. INFORMATION PROCESSING DEFICITS IN SCHIZOTYPAL PATIENTS
    Kristin Cadenhead; Fiscal Year: 1999
    ..and utilizing novel information processing measures in order to identify deficits in subjects with schizotypal personality disorder (SPD)...
  10. Behavioral and fMRI Study: Social Reciprocity in Schizotypal Personality Disorder
    Chandlee Dickey; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Social impairment is a prominent feature of schizotypal personality disorder (SPD) and is often manifested in subjects by having few friends and long periods of unemployment...
  11. Gamma Synchronization in Schizophrenia Spectrum Disorder
    BRIAN O DONNELL; Fiscal Year: 2001
    ..whether auditory neural circuits can support gamma range synchronization in schizophrenia, or in schizotypal personality disorder. Schizotypal personality disorder is genetically and symptomatically related to SZ, but without the ..
  12. Neural Substrates of Emotion in Borderline Patients
    Erin Hazlett; Fiscal Year: 2008
    ..Axis I disorder or Cluster A or C personality disorders), 26 non-BPD patients (with a diagnosis of schizotypal personality disorder and no comorbid Cluster B or C personality disorders or Axis I disorder) and 26 healthy controls...
  13. THE NEURAL CIRCUITRY OF SENSORIMOTOR GATING
    Erin Hazlett; Fiscal Year: 2002
    ....
  14. VIOLENCE--INTEGRATING SOCIAL AND PHYSIOLOGICAL FACTORS
    Adrian Raine; Fiscal Year: 2003
    ....
  15. TARDIVE DYSKINESIA INCIDENCE AND ATYPICAL ANTIPSYCHOTIC
    Scott Woods; Fiscal Year: 2004
    ..The existence of a previous sample at the same site provides a useful additional comparison group. Methods including sample ascertainment and TD assessment are closely modeled after the original work. ..
  16. Enhancing the Prospective Prediction of Psychosis
    Jean Addington; Fiscal Year: 2007
    ..Each site has proven its ability to recruit prodromal patients in a previous collaboration. [unreadable] [unreadable]..
  17. TREATMENT OF PANIC DISORDER--LONG TERM STRATEGIES
    Scott Woods; Fiscal Year: 2003
    ..Thus, we are proposing to add these aims. ..
  18. Enhancing the Prospective Prediction of Psychosis
    Scott Woods; Fiscal Year: 2007
    ..Each site has provefi its ability to recruit prodromal patients in a previous collaboration. ..
  19. RESEARCH TRACK RESIDENCY TRAINING PROGRAM
    Gunvant Thaker; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  20. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone D Cannon; Fiscal Year: 2010
    ....
  21. Pathways to Distured Emotions, Perceptions & Beliefs
    Howard Berenbaum; Fiscal Year: 2004
    ..trauma and elevated levels of peculiar perceptions and beliefs, assessed by measuring symptoms of schizotypal personality disorder; (2) to examine whether the effects of neurodevelopmental factors and psychological trauma on ..
  22. Motion Perception in Schizophrenia
    Gunvant Thaker; Fiscal Year: 2007
    ..The proposed project is a collaborative effort--involving clinical scientists studying schizophrenia pathophysiology and basic scientists studying motion perception and eye movements. [unreadable] [unreadable]..
  23. CHARACTERIZATION OF PRODROMAL SCHIZOPHRENIA
    Barbara Cornblatt; Fiscal Year: 2009
    ..This design is expected to provide the prospective evidence base essential to develop effective, stage-specific interventions targeting a broad spectrum of outcomes. Prevention of psychosis remains a very long-term goal. ..
  24. FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS
    Gunvant Thaker; Fiscal Year: 2007
    ..Clinical information, electrophysiological and cognitive measures will be collected and compared among the groups using standard family case control analytic procedures. ..
  25. Abnormal Eye Movement in Schizophrenia: Genome-Wide Scan
    Randal Ross; Fiscal Year: 2008
    ..Linkage in both groups will assessed using methods capable of detecting genetic effects on quantitative traits. ..
  26. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Gunvant K Thaker; Fiscal Year: 2010
    ....
  27. COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER
    Thomas McGlashan; Fiscal Year: 2008
    ....
  28. Semantic knowledge and its underlying structures in schizophrenia-an fMRI study
    Margaret Niznikiewicz; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Childhood Physiology and Risk for Schizophrenia
    Randal Ross; Fiscal Year: 2008
    ..Clarification of this methodology may lead to a novel prenatal intervention strategy designed to decrease risk for adolescent and adult onset of psychosis. ..
  30. M-CPP/PET IN IMPULSIVE PERSONALITY DISORDERS
    Larry Siever; Fiscal Year: 2001
    ....
  31. Working Memory and Social Functioning in Schizophrenia
    Tyrone Cannon; Fiscal Year: 2007
    ..abstract_text> ..
  32. EARLY DETECTION AND INTERVENTION IN PSYCHOSIS
    Thomas McGlashan; Fiscal Year: 2003
    ..studies as follows: 4) Ascertaining the frequency, nature, and consequences of prodromal states in Schizotypal Personality Disorder and 5) The epidemiology of prodromal states in first degree relatives of schizophrenic patients in ..
  33. Perinatal Vulnerability to Psychosis
    Randal Ross; Fiscal Year: 2004
    ....
  34. Social Anhedonia and Schizophrenia Proneness
    JACK BLANCHARD; Fiscal Year: 2005
    ....
  35. Language Systems in Schizophrenia: Behavioral & ERP Data
    Margaret Niznikiewicz; Fiscal Year: 2006
    ..DSM-IV diagnosed clinical groups: chronic schizophrenia (CS), first episode schizophrenia (FES) and schizotypal personality disorder (SPD), and their matched normal controls...
  36. Anterior Cingulate, Prefrontal Cortex, and Conflict-Control Loop Theory
    JOHN KERNS; Fiscal Year: 2006
    ..abstract_text> ..
  37. The Effect of Cannabis Use on Human Cerebellar Function
    PATRICK SKOSNIK; Fiscal Year: 2008
    ..Project Narrative [unreadable] [unreadable] [unreadable]..
  38. Liability Markers for Deficit Schizophrenia?
    L Hong; Fiscal Year: 2004
    ..We plan to use the preliminary data collected from this grant support to guide our full-scale search for phenotypic markers specifically associated with the liability for deficit schizophrenia and subsequent molecular genetic studies. ..
  39. Course of Functional Deficits in Late-Life Schizophrenia
    Philip Harvey; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  40. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Matcheri S Keshavan; Fiscal Year: 2010
    ....
  41. Visual Processing in Schizophrenia and SPD
    BRIAN O DONNELL; Fiscal Year: 2009
    ..processing, and cognitive integration in patients with schizophrenia and in participants with schizotypal personality disorder (SPD)...
  42. Electrophysiological Correlates of Anhedonia in Schizophrenia
    WILLIAM HORAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  43. Identifying molecular path of behavioural phenotype in schizophrenia
    L Hong; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  44. Rehabilitation, Brain Function and Early Schizophrenia
    Matcheri Keshavan; Fiscal Year: 2005
    ..An understanding of the cerebral correlates of improvement (or lack thereof) in cognition and behavior might guide development of future cognitive rehabilitation strategies for schizophrenia. ..
  45. Neurologic Predictors of Schizophrenia
    Jason Schiffman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  46. Neurobehavioral correlates of bipolar disorder
    BRIAN O DONNELL; Fiscal Year: 2006
    ..abstract_text> ..
  47. Prediction of Psychosis in Schizotypal Adolescents
    Elaine Walker; Fiscal Year: 2006
    ..Findings from our preliminary research indicate that adolescents with schizotypal personality disorder (SPD) manifest several physical indicators that have been observed in schizophrenia patients, ..
  48. Schizophrenia risk to onset: Neurobiology and prevention
    Cheryl Corcoran; Fiscal Year: 2008
    ..This study will provide the applicant with the knowledge and research experience necessary to apply for an R01 to further evaluate risk factors, mediators and markers of psychosis onset in prodromal patients. ..
  49. BRAIN MATURATION AND VULNERABILITY TO SCHIZOPHRENIA
    Matcheri Keshavan; Fiscal Year: 2008
    ..These studies will establish a cohort of high-risk subjects for further follow-up studies of developmental vulnerability to schizophrenia. ..
  50. EARLY VISUAL PROCESSING IN SCHIZOPHRENIA
    Michael F Green; Fiscal Year: 2010
    ....
  51. Sensory Processing Deficits in Cannabis Use
    PATRICK SKOSNIK; Fiscal Year: 2006
    ..Taken together, this data may serve to elucidate whether the known cognitive dysfunction observed in cannabis use is in part related to disturbances in early sensory information processing and/or neural synchronization. ..
  52. Family Study of Personality Traits and Their Relationship to Psychiatric Disorder
    John Gunderson; Fiscal Year: 2009
    ..Finally, we will use this study's sample to develop a gene bank for future exploration of genetic associations with BPD and its phenotypic traits. ..
  53. GENETIC LINKAGE STUDY OF SCHIZOPHRENIA
    Ming Tsuang; Fiscal Year: 2001
    ..This, and Millennium's prior genotyping experience shows that the genotyping phase of the work is feasible. ..
  54. TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTS
    Joan Asarnow; Fiscal Year: 2006
    ..This site is based in Pittsburgh, which also serves as the Data Coordinating Center for the study [unreadable] [unreadable]..
  55. ADULT ANTISOCIAL OUTCOMES OF PSYCHOPATHIC CHILDREN
    Donald Lynam; Fiscal Year: 2003
    ..5) what factors account for and mediate the stability in psychopathy across time; 6) if subclinical or so-called "successful" psychopaths can be identified and what factors distinguish them from unsuccessful psychopaths. ..
  56. Cortical-Striatal Dysfunction and Vulnerability to Schizophrenia
    Robert Asarnow; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  57. MOLECULAR GENETICS OF HEROIN DEPENDENCE
    Ming Tsuang; Fiscal Year: 2004
    ..All genotypes will be available one year after they are generated, but no later than a year after the end of the funding period. We are submitting this proposal using the RO1 mechanism. ..
  58. Genetics of Schizophrenia in Oceanic Palau.
    Marina Myles Worsley; Fiscal Year: 2009
    ..Molecular and fine-mapping studies will identify risk loci. We believe this study is unique among studies of Scz genetics for its population, sample, research team and the novelty of hypotheses and approach. ..
  59. Emotional Information Processing & IED: An fMRI Study
    Michael McCloskey; Fiscal Year: 2004
    ..abstract_text> ..
  60. TREATMENT OF NEGATIVE SYMPTOMS & COGNITIVE IMPAIRMENTS
    William Carpenter; Fiscal Year: 2003
    ..The study will provide new information on the efficacy of d- cyclosporine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
  61. TRANSMISSION OF VULNERABILITY FACTORS FOR SCHIZOPHRENIA
    Keith Nuechterlein; Fiscal Year: 2006
    ..These goals will be addressed through data collection with schizophrenic probands and their first-degree relatives as well as with demographically matched community controls and their first-degree relatives. ..