Genomes and Genes
Summary: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
Publications341 found, 100 shown here
- Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorderManuel A R Ferreira
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nat Genet 40:1056-8. 2008To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G)...
- Identification of loci associated with schizophrenia by genome-wide association and follow-upMichael C O'Donovan
Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
Nat Genet 40:1053-5. 2008..Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).
- Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorderPeter Holmans
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Heath Park, CF23 6BQ Cardiff, UK
Am J Hum Genet 85:13-24. 2009..The method was also applied to a meta-analysis of bipolar disorder, and it implicated the modulation of transcription and cellular activity, including that which occurs via ..
- Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based studyPaul Lichtenstein
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Lancet 373:234-9. 2009Whether schizophrenia and bipolar disorder are the clinical outcomes of discrete or shared causative processes is much debated in psychiatry...
- Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorderSven Cichon
Institute of Neuroscience and Medicine INM 1, Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, Juelich, Germany
Am J Hum Genet 88:372-81. 2011We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder...
- Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorderEmma L Dempster
MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Hum Mol Genet 20:4786-96. 2011Studies of the major psychoses, schizophrenia (SZ) and bipolar disorder (BD), have traditionally focused on genetic and environmental risk factors, although more recent work has highlighted an additional role for epigenetic processes in ..
- After GWAS: searching for genetic risk for schizophrenia and bipolar disorderElliot S Gershon
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, USA
Am J Psychiatry 168:253-6. 2011..Study groups even larger than the 10,000 subjects in current meta-analyses would be required, but the outcomes may lead to resolution of our current dilemma in common diseases: Where is the missing heritability?..
- Genome-wide association study of bipolar disorder in European American and African American individualsE N Smith
Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, CA, USA
Mol Psychiatry 14:755-63. 2009To identify bipolar disorder (BD) genetic susceptibility factors, we conducted two genome-wide association (GWA) studies: one involving a sample of individuals of European ancestry (EA; n=1001 cases; n=1033 controls), and one involving a ..
- Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorderMatthew J Kempton
Department of Neuroimaging, PO89, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, England
Arch Gen Psychiatry 68:675-90. 2011Although differences in clinical characteristics exist between major depressive disorder (MDD) and bipolar disorder (BD), consistent structural brain abnormalities that distinguish the disorders have not been identified.
- Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiativeKathleen R Merikangas
National Institute of Mental Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 68:241-51. 2011..There is limited information on the prevalence and correlates of bipolar spectrum disorder in international population-based studies using common methods...
- Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundariesHywel J Williams
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Hum Mol Genet 20:387-91. 2011..studies point strongly to a partial overlap in the genes that contribute susceptibility to schizophrenia and bipolar disorder (BD)...
- Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divideJonathan Savitz
Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
Neurosci Biobehav Rev 33:699-771. 2009Both major depressive disorder and bipolar disorder are the subject of a voluminous imaging and genetics literature...
- Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depressionNatalia S Lawrence
Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
Biol Psychiatry 55:578-87. 2004b>Bipolar disorder (BD) is characterised by abnormalities in mood and emotional processing, but the neural correlates of these, their relationship to depressive symptoms, and the similarities with deficits in major depressive disorder (MDD) ..
- A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium responseMichael J McCarthy
Veterans Affairs San Diego Healthcare System, San Diego, California, United Sates of America
PLoS ONE 7:e32091. 2012Circadian rhythm abnormalities in bipolar disorder (BD) have led to a search for genetic abnormalities in circadian "clock genes" associated with BD...
- The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophreniaE K Green
Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Mol Psychiatry 15:1016-22. 2010..CACNA1C, the gene encoding the α-1C subunit of the L-type voltage-gated calcium channel) with the risk of bipolar disorder (BD) has recently been reported in a meta-analysis of three genome-wide association studies of BD, including ..
- A quantitative meta-analysis of fMRI studies in bipolar disorderChi Hua Chen
Brain Mapping Unit, Department of Psychiatry, University of Cambridge GlaxoSmithKline Clinical Unit Cambridge, Addenbrooke s Hospital, Cambridge, UK
Bipolar Disord 13:1-15. 2011..fMRI) has been widely used to identify state and trait markers of brain abnormalities associated with bipolar disorder (BD)...
- Circadian genes, rhythms and the biology of mood disordersColleen A McClung
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Pharmacol Ther 114:222-32. 2007..have suggested that abnormalities in circadian rhythms may underlie the development of mood disorders such as bipolar disorder (BPD), major depression and seasonal affective disorder (SAD)...
- Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic groupCarmen Simonsen
Department of Psychology, University of Oslo, 0317 Oslo, Norway
Schizophr Bull 37:73-83. 2011..We asked whether neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends more on history of psychosis than diagnostic category or subtype...
- Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009Lakshmi N Yatham
Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
Bipolar Disord 11:225-55. 2009The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update...
- Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmissionKathleen Askland
Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
Hum Genet 125:63-79. 2009Despite known heritability, the complex genetic architecture of bipolar disorder (likely including trait, locus and allelic heterogeneity, as well as genetic interactions) has confounded genetic discovery for many years...
- Impaired verbal memory in young adults with unipolar and bipolar depressionDaniel F Hermens
Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
Early Interv Psychiatry 4:227-33. 2010..Specifically, deficits in verbal memory have been linked to depression in young people. This study examined whether young adults with unipolar compared with bipolar depression showed similar neurocognitive deficits...
- Major depressive disorder with subthreshold bipolarity in the National Comorbidity Survey ReplicationJules Angst
Department of Psychiatry, Zurich University Psychiatric Hospital, Zurich, Switzerland
Am J Psychiatry 167:1194-201. 2010..The authors examined the prevalence and clinical correlates of major depressive disorder with subthreshold bipolarity compared with pure major depressive disorder in the National Comorbidity Survey Replication (NCS-R)...
- Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorderH J Williams
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Mol Psychiatry 16:429-41. 2011..61 × 10(-7)), and stronger evidence when the phenotype was broadened to include bipolar disorder (P=9.96 × 10(-9))...
- Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depressionJie Huang
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 167:1254-63. 2010..Linkage and candidate gene studies have also suggested overlap across schizophrenia, bipolar disorder, and major depressive disorder...
- Prevalence and characteristics of undiagnosed bipolar disorders in patients with a major depressive episode: the BRIDGE studyJules Angst
The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Arch Gen Psychiatry 68:791-8. 2011..Many patients with major depressive episodes who have an underlying but unrecognized bipolar disorder receive pharmacologic treatment with ineffective regimens that do not include mood stabilizers.
- High frequencies of de novo CNVs in bipolar disorder and schizophreniaDheeraj Malhotra
Beyster Center for Genomics of Psychiatric Diseases, University of California, San Diego, La Jolla, CA 92093, USA
Neuron 72:951-63. 2011..rare copy-number variants (CNVs) contribute to risk for some neuropsychiatric disorders, the role of CNVs in bipolar disorder is unclear...
- Mitochondria, oligodendrocytes and inflammation in bipolar disorder: evidence from transcriptome studies points to intriguing parallels with multiple sclerosisChristine Konradi
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
Neurobiol Dis 45:37-47. 2012Gene expression studies of bipolar disorder (BPD) have shown changes in transcriptome profiles in multiple brain regions...
- Genome wide association studies (GWAS) and copy number variation (CNV) studies of the major psychoses: what have we learnt?Kok Wei Lee
Institute of Mental Health Woodbridge Hospital 10, Buangkok View, Singapore 539747, Singapore
Neurosci Biobehav Rev 36:556-71. 2012Schizophrenia (SZ) and bipolar disorder (BPD) have high heritabilities and are clinically and genetically complex...
- Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorderMichael P Moreau
Department of Genetics, Rutgers University, Piscataway, New Jersey 08854 8095, USA
Biol Psychiatry 69:188-93. 2011..MicroRNAs (miRNAs) are potent regulators of gene expression with proposed roles in brain development and function. We hypothesized that miRNA expression profiles are altered in individuals with severe psychiatric disorders...
- A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorderM L Phillips
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Mol Psychiatry 13:829, 833-57. 2008..model as a theoretical framework to examine functional neural abnormalities in these neural systems that may predispose to the development of a major psychiatric disorder characterized by severe emotion dysregulation, bipolar disorder.
- Neural mechanisms of a genome-wide supported psychosis variantChristine Esslinger
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
Science 324:605. 2009..Recently, the first common genetic variant associated on a genome-wide level with schizophrenia and possibly bipolar disorder was discovered in ZNF804A (rs1344706)...
- Mitochondrial dysfunction and pathology in bipolar disorder and schizophreniaHayley B Clay
Neuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA
Int J Dev Neurosci 29:311-24. 2011b>Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in these disorders...
- Neurocognitive profiles in bipolar I and bipolar II disorder: differences in pattern and magnitude of dysfunctionCarmen Simonsen
Department of Psychiatry, Ulleval University Hospital, and Institute of Psychology, University of Oslo, Oslo, Norway
Bipolar Disord 10:245-55. 2008Studies on neurocognitive functioning in bipolar disorder, reporting deficits in memory, attention, and executive functioning, have primarily focused on bipolar I disorder...
- Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disordersK Iwamoto
Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, Saitama, Japan
Mol Psychiatry 9:406-16. 2004We performed the oligonucleotide microarray analysis in bipolar disorder, major depression, schizophrenia, and control subjects using postmortem prefrontal cortices provided by the Stanley Foundation Brain Collection...
- Anatomy of bipolar disorder and schizophrenia: a meta-analysisIan Ellison-Wright
Brain Mapping Unit, University of Cambridge, Cambridge, UK
Schizophr Res 117:1-12. 2010..results have indicated that the two major, classically distinct forms of psychosis - schizophrenia and bipolar disorder - may share causative factors in common...
- Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic riskV Moskvina
Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
Mol Psychiatry 14:252-60. 2009..We have undertaken gene-wide analysis of two GWAS data sets: schizophrenia and bipolar disorder. We performed two forms of analysis, one based on the smallest P-value per gene, the other on a truncated ..
- Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorderColin A Hodgkinson
Section of Human Neurogenetics and Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
Am J Hum Genet 75:862-72. 2004Schizophrenia, schizoaffective disorder, and bipolar disorder are common psychiatric disorders with high heritabilities and variable phenotypes...
- Hippocampal volume and depression: a meta-analysis of MRI studiesPoul Videbech
Institute for Basic Psychiatric Research, Department of Biological Psychiatry, Psychiatric Hospital, Aarhus University Hospital, DK 8240 Risskov, Denmark
Am J Psychiatry 161:1957-66. 2004..The authors performed a systematic review and meta-analysis of volumetric studies of the hippocampus in patients with mood disorders...
- Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genesM M Ryan
Cambridge Centre for Neuropsychiatric Research, Institute of Biotechnology, University of Cambridge, Cambridge, UK
Mol Psychiatry 11:965-78. 2006..of approximately 22,000 mRNA transcripts in post-mortem tissue from two brain regions in patients with bipolar disorder and matched healthy controls...
- Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factorsM Berk
Department of Clinical and Biomedical Sciences, University of Melbourne, Victoria 3010, Australia
Neurosci Biobehav Rev 35:804-17. 2011There is now strong evidence of progressive neuropathological processes in bipolar disorder (BD)...
- The heritability of bipolar affective disorder and the genetic relationship to unipolar depressionPeter McGuffin
Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, England
Arch Gen Psychiatry 60:497-502. 2003..There has been little use of genetic model fitting and no analyses to explore the etiological overlap with unipolar depression (UPD)...
- Cortical thickness and subcortical volumes in schizophrenia and bipolar disorderLars M Rimol
Department of Psychiatry, section Vinderen, University of Oslo, Oslo, Norway
Biol Psychiatry 68:41-50. 2010Schizophrenia and bipolar disorder are severe psychiatric diseases with overlapping symptomatology...
- Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophreniaDetelina Grozeva
Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, UK
Arch Gen Psychiatry 67:318-27. 2010..The possible involvement of copy number variants (CNVs) in bipolar disorder has received little attention to date.
- Temporal lobe and "default" hemodynamic brain modes discriminate between schizophrenia and bipolar disorderVince D Calhoun
Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut, USA
Hum Brain Mapp 29:1265-75. 2008Schizophrenia and bipolar disorder are currently diagnosed on the basis of psychiatric symptoms and longitudinal course...
- Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHDHeike Weber
Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Wurzburg, Wurzburg, Germany
Neuropsychopharmacology 36:2076-85. 2011Recently, several genome-wide association studies (GWAS) on bipolar disorder (BPD) suggested novel risk genes. However, only few of them were followed up and further, the specificity of these genes is even more elusive...
- Is sex important? Gender differences in bipolar disorderArianna Diflorio
MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Heath Park, Cardiff, UK
Int Rev Psychiatry 22:437-52. 2010..In the case of bipolar disorder, however, it is widely perceived that the reported equal rate of illness in men and women reflects no ..
- DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorderW Hennah
Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU, Scotland
Mol Psychiatry 14:865-73. 2009Disrupted in schizophrenia 1 (DISC1) has been associated with risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism and Asperger syndrome, but apart from in the original translocation family, true ..
- A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorderZ Kaminsky
The Krembil Family Epigenetics Laboratory, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, ON, Canada
Mol Psychiatry 17:728-40. 2012..fine mapping DNA methylation differences at the human leukocyte antigen (HLA) complex group 9 gene (HCG9) in bipolar disorder (BPD)...
- Mania-like behavior induced by disruption of CLOCKKole Roybal
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 104:6406-11. 2007Circadian rhythms and the genes that make up the molecular clock have long been implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central transcriptional activator of molecular rhythms, CLOCK, may be ..
- The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)Agustin Ibanez
Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology, Favaloro University, Buenos Aires, Argentina
PLoS ONE 7:e37306. 2012Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making...
- The loudness dependence of the auditory evoked potential (LDAEP) in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controlsYoung Min Park
Department of Psychiatry, Inje University, Ilsan Paik Hospital, 2240 Daehwa dong, Ilsanseo gu, Goyang 411 706, South Korea
Prog Neuropsychopharmacol Biol Psychiatry 34:313-6. 2010Serotonergic dysfunction in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controls was evaluated by measuring the activity of the loudness dependence of the auditory evoked potential (LDAEP).
- Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder QuestionnaireR M Hirschfeld
Department of Psychiatry and Behavioral Sciences, Medical Branch, the University of Texas at Galveston 77555 01888, USA
Am J Psychiatry 157:1873-5. 2000Bipolar spectrum disorders, which include bipolar I, bipolar II, and bipolar disorder not otherwise specified, frequently go unrecognized, undiagnosed, and untreated...
- The functional neuroanatomy of bipolar disorderMichael A Cerullo
Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Int Rev Psychiatry 21:314-22. 2009..manuscript, research articles using functional magnetic resonance imaging (fMRI) to study adult patients with bipolar disorder were reviewed...
- Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathwayN Matigian
Queensland Centre for Mental Health Research, Herston, QLD, Australia
Mol Psychiatry 12:815-25. 2007To identify genes dysregulated in bipolar disorder (BD1), we carried out global gene expression profiling using whole-genome microarrays...
- The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relativesG Lelli-Chiesa
Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, UK
Psychol Med 41:779-88. 2011..is also thought to increase the risk of a number of disorders characterized by affective morbidity including bipolar disorder (BD), major depressive disorder (MDD) and anxiety disorders...
- Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorderD Cotter
Department of Psychological Medicine and Neuropathology, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, England
Arch Gen Psychiatry 58:545-53. 2001..In this investigation, we have simultaneously assessed glial cell density and neuronal density and size in the anterior cingulate cortex in schizophrenia, major depressive disorder, and bipolar disorder.
- Brain metabolic alterations in medication-free patients with bipolar disorderStephen R Dager
Department of Radiology, University of Washington, Seattle 98105, USA
Arch Gen Psychiatry 61:450-8. 2004b>Bipolar disorder (BD) has substantial morbidity and incompletely understood neurobiological underpinnings.
- Genome-wide association study of bipolar I disorder in the Han Chinese populationM T M Lee
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Mol Psychiatry 16:548-56. 2011..55 × 10(-5) and P=1.48 × 10(-5), respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder...
- Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulationAllison G Harvey
Sleep and Psychological Disorders Lab, Department of Psychology, University of California, 3210 Tolman Hall, 1650, Berkeley, CA 94720 1650, USA
Am J Psychiatry 165:820-9. 2008Despite advances in the treatment of bipolar disorder, a significant proportion of patients experience disabling symptoms between episodes, and relapse rates are high...
- Epigenomic profiling reveals DNA-methylation changes associated with major psychosisJonathan Mill
Krembil Family Epigenetic Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
Am J Hum Genet 82:696-711. 2008Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia and bipolar disorder. To date, however, few studies have investigated the role of DNA methylation in major psychosis, and none have taken a genome-..
- The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the treatment of acute bipolar depressionHeinz Grunze
Newcastle University, RVI, Division of Psychiatry, Institute of Neuroscience, Newcastle upon Tyne, UK
World J Biol Psychiatry 11:81-109. 2010..Their purpose is to supply a systematic overview of all scientific evidence pertaining to the treatment of acute bipolar depression in adults...
- The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatientsJules Angst
Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 1931, 8032 Zurich, Switzerland
J Affect Disord 88:217-33. 2005..As such, an instrument for self-assessment of hypomanic symptoms might increase the detection of suspected and of manifest, but under-treated, cases of bipolar disorders...
- High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramidesEmanuel Schwarz
Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom
J Proteome Res 7:4266-77. 2008..lipid levels in the prefrontal cortex (Brodmann area 9) of 45 subjects including 15 schizophrenia and 15 bipolar disorder patients as well as 15 controls samples...
- Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestryLaura J Scott
Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 106:7501-6. 2009b>Bipolar disorder (BP) is a disabling and often life-threatening disorder that affects approximately 1% of the population worldwide...
- Collaborative care for bipolar disorder: part I. Intervention and implementation in a randomized effectiveness trialMark S Bauer
Providence Veterans Affairs Medical Center VANC, Rhode Island 02908 4799, USA
Psychiatr Serv 57:927-36. 2006Outcome for bipolar disorder remains suboptimal despite the availability of efficacious treatments...
- Evidence-based guidelines for treating bipolar disorder: revised second edition--recommendations from the British Association for PsychopharmacologyG M Goodwin
University Department of Psychiatry, Warneford Hospital, Oxford, UK
J Psychopharmacol 23:346-88. 2009The British Association for Psychopharmacology guidelines specify the scope and target of treatment for bipolar disorder. The second version, like the first, is based explicitly on the available evidence and presented, like previous ..
- The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorderRoosmarijn C Drexhage
Department of Immunology, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
Expert Rev Neurother 10:59-76. 2010This review describes patients with schizophrenia and bipolar disorder. In such patients, a high inflammatory set point of circulating monocytes at the transcriptome level is observed, involving various inflammatory transcripts forming ..
- National trends in the outpatient diagnosis and treatment of bipolar disorder in youthCarmen Moreno
Unidad de Adolescentes, Hospital General Universitario Gregorio Maranon, Servicio do Psiquiatría, Madrid, Spain
Arch Gen Psychiatry 64:1032-9. 2007Although bipolar disorder may have its onset during childhood, little is known about national trends in the diagnosis and management of bipolar disorder in young people.
- Bipolar depression: overview and commentaryRoss J Baldessarini
Harvard Medical School, McLean Hospital, Belmont, MA, USA
Harv Rev Psychiatry 18:143-57. 2010..Interest in recognizing bipolar depression and seeking more effective, specific, and safer treatments for it are growing...
- The use of antidepressants in bipolar disorderVirginio Salvi
Department of Neuroscience, University of Turin, Italy
J Clin Psychiatry 69:1307-18. 2008Whether or not to use antidepressants in patients with bipolar disorder is a matter of debate. Antidepressant treatment of bipolar depression has been associated with manic switch and cycle acceleration...
- Premature mortality from general medical illnesses among persons with bipolar disorder: a reviewBabak Roshanaei-Moghaddam
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, USA
Psychiatr Serv 60:147-56. 2009Despite recent evidence that patients with bipolar disorder are at increased risk of premature mortality resulting from general medical disorders, there has been no systematic review of published studies...
- Asenapine for long-term treatment of bipolar disorder: a double-blind 40-week extension studyRoger S McIntyre
Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, ON, Canada
J Affect Disord 126:358-65. 2010..We report the results of long-term treatment with asenapine in patients with bipolar I disorder...
- No evidence for excess runs of homozygosity in bipolar disorderAnna E Vine
Centre for Psychiatry, University College London, UK
Psychiatr Genet 19:165-70. 2009..Of these, four contained or neighboured genes associated with schizophrenia (NOS1AP/UHMK1, ATF2, NSF and PIK3C3)...
- Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomaniaJules Angst
Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 68, CH 8029, Zurich, Switzerland
J Affect Disord 73:133-46. 2003..to develop and validate criteria for the definition of softer expressions of bipolar-II (BP-II) disorder and hypomania, (3). to demonstrate the prevalence, clinical validity and comorbidity of the entire soft bipolar spectrum...
- Enhanced relapse prevention for bipolar disorder--ERP trial. A cluster randomised controlled trial to assess the feasibility of training care coordinators to offer enhanced relapse prevention for bipolar disorderFiona Lobban
School of Psychological Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
BMC Psychiatry 7:6. 2007b>Bipolar Disorder (BD) is a common and severe form of mental illness characterised by repeated relapses of mania or depression. Pharmacotherapy is the main treatment currently offered, but this has only limited effectiveness...
- Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the Course and Outcome of Bipolar Youth (COBY) studyBoris Birmaher
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 166:795-804. 2009..The authors sought to assess the longitudinal course of youths with bipolar spectrum disorders over a 4-year period...
- Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relativesEmre Bora
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Vic, Australia
J Affect Disord 113:1-20. 2009Our aim was to delineate neuropsychological deficits related to genetic susceptibility, illness process and iatrogenic factors in bipolar disorder (BD).
- Reduced expression of human endogenous retrovirus (HERV)-W GAG protein in the cingulate gyrus and hippocampus in schizophrenia, bipolar disorder, and depressionS Weis
Laboratory of Brain Research and Neuropathology, Departments of Psychiatry and Pathology, Uniformed Services University of the Health Sciences, and Stanley Medical Research Institute, Bethesda, MD, USA
J Neural Transm 114:645-55. 2007..anterior cingulate cortex and hippocampal formation of normal controls and of patients with schizophrenia, bipolar disorder and major depression...
- Whole-genome association study of bipolar disorderP Sklar
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Psychiatry 13:558-69. 2008..with bipolar (BP) 1 disorder, 2008 controls drawn from the Systematic Treatment Enhancement Program for Bipolar Disorder and the University College London sample collections with successful genotyping for 372,193 single nucleotide ..
- A randomized trial on the efficacy of group psychoeducation in the prophylaxis of recurrences in bipolar patients whose disease is in remissionFrancesco Colom
Bipolar Disorders Program, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS Barcelona, Spain
Arch Gen Psychiatry 60:402-7. 2003..However, there has been a lack of structured, well-designed, blinded, controlled studies demonstrating the efficacy of group psychoeducation to prevent recurrences in patients with bipolar I and II disorder...
- Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trialJohn R Geddes
Oxford Clinical Trials Unit for Mental Illness, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
Lancet 375:385-95. 2010Lithium carbonate and valproate semisodium are both recommended as monotherapy for prevention of relapse in bipolar disorder, but are not individually fully effective in many patients...
- Maintenance treatment for patients with bipolar I disorder: results from a north american study of quetiapine in combination with lithium or divalproex (trial 127)Trisha Suppes
3801 Miranda Ave 151 T, Palo Alto, CA 94304, USA
Am J Psychiatry 166:476-88. 2009..The authors evaluated the efficacy and safety of quetiapine plus lithium or divalproex in the prevention of recurrent mood events in patients with stabilized bipolar I disorder...
- Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processingYuan Su
Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
Biochemistry 43:6899-908. 2004Lithium is one of the most widely used mood-stabilizing agents for the treatment of bipolar disorder. Although the underlying mechanism(s) of this mood stabilizer remains controversial, recent evidence linking lithium to neurotrophic/..
- Trends in the treatment of bipolar disorder by outpatient psychiatristsCarlos Blanco
Department of Psychiatry and New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
Am J Psychiatry 159:1005-10. 2002This study examined recent changes in the prescribing patterns for medications to treat bipolar disorder in office-based psychiatric practice.
- Ziprasidone monotherapy in bipolar II depression: an open trialMichael R Liebowitz
The Medical Research Network, LLC, New York, NY 10024, USA
J Affect Disord 118:205-8. 2009....
- Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorderL Zhan
Clinical Developmental Sciences, St George s University of London, Cranmer Terrace, London
Neuropathol Appl Neurobiol 37:206-19. 2011signalling through dopamine receptors is of critical importance in the brain and is implicated in schizophrenia and bipolar disorder, but its underlying molecular mechanisms remain poorly understood.
- Reporting outcomes in clinical trials for bipolar disorder: a commentary and suggestions for changeAnabel Martinez-Aran
Bipolar Disorders Program, IDIBAPS, CIBER SAM, Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, Barcelona, Spain
Bipolar Disord 10:566-79. 2008..translate efficacy data to evidence-based psychiatric care are needed when evaluating clinical trials for bipolar disorder. Using efficacy studies as illustrations, the authors review and recommend changes in the reporting of ..
- The role of psychotherapy in bipolar disorderSue D Lauder
Department of Clinical and Biomedical Sciences Barwon Health, University of Melbourne, Geelong, Vic, Australia
Med J Aust 193:S31-5. 2010Adjunctive psychosocial interventions for bipolar disorder target many of the issues that are not addressed by medication alone, including non-adherence, efficacy-effectiveness gap and functionality...
- White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imagingJessika E Sussmann
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
Bipolar Disord 11:11-8. 2009Strong qualitative and quantitative evidence exists of white matter abnormalities in both schizophrenia and bipolar disorder (BD). Diffusion tensor imaging (DTI) studies suggest altered connectivity in both disorders...
- Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expressionEkrem Maloku
Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA
Proc Natl Acad Sci U S A 107:4407-11. 2010..This finding suggests that lack of reelin impairs GABAergic Purkinje neuron expression and/or positioning during cerebellar development...
- Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuseM Kathleen Holmes
Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Bipolar Disord 11:33-40. 2009Elevated levels of impulsivity and increased risk taking are thought to be core features of both bipolar disorder (BD) and addictive disorders...
- Prepubertal mania: diagnostic differences between US and UK cliniciansBernadka Dubicka
University of Manchester and The Junction Adolescent Unit, Piccadilly, Lancaster LA1 4PW, UK
Eur Child Adolesc Psychiatry 17:153-61. 2008..To test the hypothesis that US clinicians diagnose prepubertal mania more commonly than UK clinicians...
- Group psychoeducation for stabilised bipolar disorders: 5-year outcome of a randomised clinical trialF Colom
Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic of Barcelona, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
Br J Psychiatry 194:260-5. 2009..The long-term efficacy of psychological interventions for bipolar disorders has not been tested...
- Searching genetic risk factors for schizophrenia and bipolar disorder: learn from the past and back to the futureMaaike Alaerts
Applied Molecular Genomics Group, Vlaams Instituut voor Biotechnologie Flanders Institute for Biotechnology, Department of Molecular Genetics, University of Antwerp, Antwerp B 2610, Belgium
Hum Mutat 30:1139-52. 2009..We discuss what can be learned from the past and how this knowledge can be used in future study designs...
- Clinical diagnoses in young offspring from eastern Québec multigenerational families densely affected by schizophrenia or bipolar disorderM Maziade
Centre de Recherche Universite Laval Robert Giffard, QC, Canada
Acta Psychiatr Scand 117:118-26. 2008..sample of multigenerational families of eastern Québec that are densely affected by schizophrenia (SZ) or bipolar disorder (BP) has permitted to look at the rates of DSM diagnoses in the young offspring of a SZ parent (HRSZ) and of ..
- Efficacy of ziprasidone in dysphoric mania: pooled analysis of two double-blind studiesS Stahl
Department of Psychiatry, UCSD, San Diego, CA 92008, USA
J Affect Disord 122:39-45. 2010..Dysphoric mania is a common and often difficult to treat subset of bipolar mania that is associated with significant depressive symptoms...
- Association study of Wnt signaling pathway genes in bipolar disorderPeter P Zandi
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
Arch Gen Psychiatry 65:785-93. 2008The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder.
- Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1Ting Ting Chang
Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan
Bipolar Disord 12:102-6. 2010Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients.
- Bipolar disorder and mechanisms of action of mood stabilizersStanley I Rapoport
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Brain Res Rev 61:185-209. 2009b>Bipolar disorder (BD) is a major medical and social burden, whose cause, pathophysiology and treatment are not agreed on...
- The genetics of bipolar disorderJ H Barnett
Center for Human Genetic Research, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Neuroscience 164:331-43. 2009b>Bipolar disorder is a mood disorder characterized by impairing episodes of mania and depression...
Research Grants106 found, 100 shown here
- Molecular Interventions for Bipolar DisorderALAN PAUL KOZIKOWSKI; Fiscal Year: 2010..than 2 million American adults, or about 1 percent of the population age 18 and older in any given year, have bipolar disorder. Current treatments include the so-called "mood stabilizers," lithium and valproic acid...
- Molecular Interventions for Bipolar DisorderAlan Kozikowski; Fiscal Year: 2009..than 2 million American adults, or about 1 percent of the population age 18 and older in any given year, have bipolar disorder. Current treatments include the so-called "mood stabilizers," lithium and valproic acid...
- Molecular Interventions for Bipolar DisorderAlan Kozikowski; Fiscal Year: 2007..than 2 million American adults, or about 1 percent of the population age 18 and older in any given year, have bipolar disorder. Current treatments include the so-called "mood stabilizers," lithium and valproic acid...
- Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar DisorderDavid Miklowitz; Fiscal Year: 2007b>Bipolar disorder (BD) in youth is associated with significant impairments in functioning, treatment-resistance, and high public health costs...
- GABAergic and Reelin Deficits in SchizophreniaSEYYED HOSSEIN FATEMI; Fiscal Year: 2010..subjects with bipolar disorder, major depression, and matched controls...
- Genetic Influences on Frontotemporal Connectivity in Bipolar DisorderHilary P Blumberg; Fiscal Year: 2011..in age-related patterns of frontotemporal (FT) connectivity in adolescents and adults with and without bipolar disorder (BD) and the genetic factors that influence them...
- INHIBITORY DEFICITS IN HUMAN AND ANIMAL MODELS OF BIPOLAR DISORDERWILLIAM contact PERRY; Fiscal Year: 2010b>Bipolar Disorder (BD) is a severe psychiatric illness that is hallmarked by manic and depressive states. Inhibitory deficits are characteristic of BD and occur throughout the various phases of the illness...
- OMEGA-3 FATTY ACIDS IN BIPOLAR DISORDER PROPHYLAXISANDREW STOLL; Fiscal Year: 2002..trial is to assess the efficacy of omega-3 fatty acids (03FA) in preventing recurrence in patients with bipolar disorder, type 1...
- Naltrexone for Bipolar Disorder and Alcohol DependenceE Sherwood Brown; Fiscal Year: 2006..b>Bipolar disorder is a severe and persistent psychiatric illness affecting 1.2-1...
- Comparative Effectiveness Study for Bipolar DisorderAndrew A Nierenberg; Fiscal Year: 2010..In fact, QTP has become the most commonly prescribed medication for bipolar disorder. This is true in spite of the observation that treatment with SGAs is associated with significant metabolic ..
- A Molecular Mechanism for Lithium ActionPeter Klein; Fiscal Year: 2007Lithium is the first line of therapy in the treatment of bipolar disorder yet its mechanism of action in this setting is not known...
- A Molecular Mechanism for Lithium ActionPeter Klein; Fiscal Year: 2009Lithium is the first line of therapy in the treatment of bipolar disorder yet its mechanism of action in this setting is not known...
- Efficacy and Safety of Galantamine for Dysfunction in Bipolar DisorderDAN VLAD IOSIFESCU; Fiscal Year: 2010..and its associated psychosocial and vocational functional impairments, occurs in many patients with bipolar disorder even when mood symptoms are adequately treated...
- Efficacy and Safety of Galantamine for Dysfunction in Bipolar DisorderDan Iosifescu; Fiscal Year: 2009..and its associated psychosocial and vocational functional impairments, occurs in many patients with bipolar disorder even when mood symptoms are adequately treated...
- DNA METHYLOME ANALYSIS IN BIPOLAR DISORDERART PETRONIS; Fiscal Year: 2010Epigenetic misregulation is consistent with various non-Mendelian features of bipolar disorder (BPD), such as the discordance of identical twins, significant fluctuations in disease course, sex- and parental origin- effects, and the ..
- Glutamine and Glutamate in Children and Adolescents with Bipolar DisorderConstance M Moore; Fiscal Year: 2010b>Bipolar Disorder (BPD) may be as common among youths as it is among adults. The lifetime prevalence for Bipolar Disorder in adults ranges from 0.6% to 1.1%...
- Glutamine and Glutamate in Children and Adolescents with Bipolar DisorderCONSTANCE MOORE; Fiscal Year: 2009b>Bipolar Disorder (BPD) may be as common among youths as it is among adults. The lifetime prevalence for Bipolar Disorder in adults ranges from 0.6% to 1.1%...
- Quetiapine for Bipolar Disorder and Alcohol DependenceE Sherwood Brown; Fiscal Year: 2010b>Bipolar disorder is a severe, persistent, and common psychiatric illness that is associated with a staggering 46% lifetime prevalence of alcohol-related disorders...
- Quetiapine for Bipolar Disorder and Alcohol DependenceE Sherwood Brown; Fiscal Year: 2007b>Bipolar disorder is a severe, persistent, and common psychiatric illness that is associated with a staggering 46% lifetime prevalence of alcohol-related disorders...
- Quetiapine for Bipolar Disorder and Alcohol DependenceE Sherwood Brown; Fiscal Year: 2009b>Bipolar disorder is a severe, persistent, and common psychiatric illness that is associated with a staggering 46% lifetime prevalence of alcohol-related disorders...
- Glucogen Synthase Kinase 3beta and Bipolar DisorderXiaohua Li; Fiscal Year: 2007..regulation of glycogen synthase kinase 3beta, its modulation by mood stabilizers and its potential role in bipolar disorder. The five-year plans to enable the candidate to develop into an independent psychiatric investigator to ..
- Valproate Efficacy in Cocaine-Bipolar ComorbidityIhsan Salloum; Fiscal Year: 2006..the efficacy of a promising pharmacological approach for the treatment of comorbid cocaine dependence and bipolar disorder. We propose a randomized, double blind, placebo-controlled, 12-week trial, to test the efficacy of Divalproex ..
- Valproate Efficacy in Cocaine-Bipolar ComorbidityIhsan Salloum; Fiscal Year: 2009..the efficacy of a promising pharmacological approach for the treatment of comorbid cocaine dependence and bipolar disorder. We propose a randomized, double blind, placebo-controlled, 12-week trial, to test the efficacy of Divalproex ..
- Reducing Medical Risks in Individuals with Bipolar DisorderDavid Kupfer; Fiscal Year: 2009..aim of this project is to understand whether it is possible to reduce medical risk factors in adults with bipolar disorder and, in doing so, to improve psychiatric and functional outcomes...
- PROTON MRSI STUDIES OF BIPOLAR DISORDERPerry Renshaw; Fiscal Year: 2001..In pilot studies of individuals with bipolar disorder, we have used 1H MRSI to evaluate brain cytosolic choline levels and, more recently, myo-inositol levels...
- Neurophysiology of Working Memory in Bipolar DisorderCaleb Adler; Fiscal Year: 2007..Caleb M. Adler's developing expertise in neuroimaging and bipolar disorder. Bipolar disorder is a common psychiatric illness accompanied by severe morbidity and mortality...
- Genetic Linkage Studies in Bipolar Disorder FamiliesElliot Gershon; Fiscal Year: 2009..Johns Hopkins, the University of Chicago, and the National Institute of Mental Health--that has developed a bipolar disorder family resource that has proven to be uniquely valuable in testing clinically based hypotheses about the ..
- International Cohort Collection for Bipolar DisorderJordan Smoller; Fiscal Year: 2009b>Bipolar disorder (BPD) is a major public health priority, responsible for a vast burden of disability, personal suffering, and economic cost...
- MRI/MRSI Studies of Bipolar Treatment ResponsePerry Renshaw; Fiscal Year: 2009..dysfunction (increased gray matter lactate and glutamate/glutamine/GABA (Glx)) in untreated patients with bipolar disorder; (2) measured changes toward normal values in brain Glx were associated with lithium treatment, but not ..
- Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar ManiaCaleb Adler; Fiscal Year: 2007....
- Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar ManiaCaleb M Adler; Fiscal Year: 2010....
- Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar ManiaCaleb Adler; Fiscal Year: 2009....
- RESEARCH TRAINING IN JUVENILE BIPOLAR DISORDERPablo Davanzo; Fiscal Year: 2002..a program of career development and research in psychopharmacology and neuroimaging of juveniles with bipolar disorder. A focus of this program will be a clinical trial with a mood-stabilizer (divalproex sodium) in a group of ..
- MRSI of Frontosubcortical Circuits in Bipolar DisorderRAYMOND DEICKEN; Fiscal Year: 2004DESCRIPTION: (provided by applicant) Developing evidence strongly suggests that bipolar disorder involves localized abnormalities in specific brain structures that participate in fronto-limbic-subcortical circuits regulating mood...
- Psychiatric Illness: Multigene Expression ClassificationJAMES CLELLAND; Fiscal Year: 2005..proposal is designed to produce data for the development of a biological classification of schizophrenia and bipolar disorder, based on high density microarray measurements of transcribed white blood cell (leukocyte) mRNA...