bipolar disorder

Summary

Summary: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.

Top Publications

  1. pmc Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    Manuel A R Ferreira
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:1056-8. 2008
  2. doi Identification of loci associated with schizophrenia by genome-wide association and follow-up
    Michael C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 40:1053-5. 2008
  3. pmc Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder
    Peter Holmans
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Heath Park, CF23 6BQ Cardiff, UK
    Am J Hum Genet 85:13-24. 2009
  4. pmc Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Lancet 373:234-9. 2009
  5. pmc Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder
    Sven Cichon
    Institute of Neuroscience and Medicine INM 1, Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, Juelich, Germany
    Am J Hum Genet 88:372-81. 2011
  6. pmc Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    Emma L Dempster
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Hum Mol Genet 20:4786-96. 2011
  7. doi After GWAS: searching for genetic risk for schizophrenia and bipolar disorder
    Elliot S Gershon
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, USA
    Am J Psychiatry 168:253-6. 2011
  8. pmc Genome-wide association study of bipolar disorder in European American and African American individuals
    E N Smith
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, CA, USA
    Mol Psychiatry 14:755-63. 2009
  9. doi Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder
    Matthew J Kempton
    Department of Neuroimaging, PO89, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 68:675-90. 2011
  10. pmc Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative
    Kathleen R Merikangas
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 68:241-51. 2011

Detail Information

Publications341 found, 100 shown here

  1. pmc Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    Manuel A R Ferreira
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:1056-8. 2008
    To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G)...
  2. doi Identification of loci associated with schizophrenia by genome-wide association and follow-up
    Michael C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 40:1053-5. 2008
    ..Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).
  3. pmc Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder
    Peter Holmans
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Heath Park, CF23 6BQ Cardiff, UK
    Am J Hum Genet 85:13-24. 2009
    ..The method was also applied to a meta-analysis of bipolar disorder, and it implicated the modulation of transcription and cellular activity, including that which occurs via ..
  4. pmc Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Lancet 373:234-9. 2009
    Whether schizophrenia and bipolar disorder are the clinical outcomes of discrete or shared causative processes is much debated in psychiatry...
  5. pmc Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder
    Sven Cichon
    Institute of Neuroscience and Medicine INM 1, Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, Juelich, Germany
    Am J Hum Genet 88:372-81. 2011
    We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder...
  6. pmc Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    Emma L Dempster
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Hum Mol Genet 20:4786-96. 2011
    Studies of the major psychoses, schizophrenia (SZ) and bipolar disorder (BD), have traditionally focused on genetic and environmental risk factors, although more recent work has highlighted an additional role for epigenetic processes in ..
  7. doi After GWAS: searching for genetic risk for schizophrenia and bipolar disorder
    Elliot S Gershon
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, USA
    Am J Psychiatry 168:253-6. 2011
    ..Study groups even larger than the 10,000 subjects in current meta-analyses would be required, but the outcomes may lead to resolution of our current dilemma in common diseases: Where is the missing heritability?..
  8. pmc Genome-wide association study of bipolar disorder in European American and African American individuals
    E N Smith
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, CA, USA
    Mol Psychiatry 14:755-63. 2009
    To identify bipolar disorder (BD) genetic susceptibility factors, we conducted two genome-wide association (GWA) studies: one involving a sample of individuals of European ancestry (EA; n=1001 cases; n=1033 controls), and one involving a ..
  9. doi Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder
    Matthew J Kempton
    Department of Neuroimaging, PO89, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 68:675-90. 2011
    Although differences in clinical characteristics exist between major depressive disorder (MDD) and bipolar disorder (BD), consistent structural brain abnormalities that distinguish the disorders have not been identified.
  10. pmc Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative
    Kathleen R Merikangas
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 68:241-51. 2011
    ..There is limited information on the prevalence and correlates of bipolar spectrum disorder in international population-based studies using common methods...
  11. doi Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
    Hywel J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 20:387-91. 2011
    ..studies point strongly to a partial overlap in the genes that contribute susceptibility to schizophrenia and bipolar disorder (BD)...
  12. pmc Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
    Neurosci Biobehav Rev 33:699-771. 2009
    Both major depressive disorder and bipolar disorder are the subject of a voluminous imaging and genetics literature...
  13. ncbi Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression
    Natalia S Lawrence
    Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 55:578-87. 2004
    b>Bipolar disorder (BD) is characterised by abnormalities in mood and emotional processing, but the neural correlates of these, their relationship to depressive symptoms, and the similarities with deficits in major depressive disorder (MDD) ..
  14. pmc A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response
    Michael J McCarthy
    Veterans Affairs San Diego Healthcare System, San Diego, California, United Sates of America
    PLoS ONE 7:e32091. 2012
    Circadian rhythm abnormalities in bipolar disorder (BD) have led to a search for genetic abnormalities in circadian "clock genes" associated with BD...
  15. pmc The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia
    E K Green
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 15:1016-22. 2010
    ..CACNA1C, the gene encoding the α-1C subunit of the L-type voltage-gated calcium channel) with the risk of bipolar disorder (BD) has recently been reported in a meta-analysis of three genome-wide association studies of BD, including ..
  16. doi A quantitative meta-analysis of fMRI studies in bipolar disorder
    Chi Hua Chen
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge GlaxoSmithKline Clinical Unit Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Bipolar Disord 13:1-15. 2011
    ..fMRI) has been widely used to identify state and trait markers of brain abnormalities associated with bipolar disorder (BD)...
  17. pmc Circadian genes, rhythms and the biology of mood disorders
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Pharmacol Ther 114:222-32. 2007
    ..have suggested that abnormalities in circadian rhythms may underlie the development of mood disorders such as bipolar disorder (BPD), major depression and seasonal affective disorder (SAD)...
  18. pmc Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group
    Carmen Simonsen
    Department of Psychology, University of Oslo, 0317 Oslo, Norway
    Schizophr Bull 37:73-83. 2011
    ..We asked whether neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends more on history of psychosis than diagnostic category or subtype...
  19. doi Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
    Bipolar Disord 11:225-55. 2009
    The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update...
  20. doi Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission
    Kathleen Askland
    Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
    Hum Genet 125:63-79. 2009
    Despite known heritability, the complex genetic architecture of bipolar disorder (likely including trait, locus and allelic heterogeneity, as well as genetic interactions) has confounded genetic discovery for many years...
  21. doi Impaired verbal memory in young adults with unipolar and bipolar depression
    Daniel F Hermens
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
    Early Interv Psychiatry 4:227-33. 2010
    ..Specifically, deficits in verbal memory have been linked to depression in young people. This study examined whether young adults with unipolar compared with bipolar depression showed similar neurocognitive deficits...
  22. pmc Major depressive disorder with subthreshold bipolarity in the National Comorbidity Survey Replication
    Jules Angst
    Department of Psychiatry, Zurich University Psychiatric Hospital, Zurich, Switzerland
    Am J Psychiatry 167:1194-201. 2010
    ..The authors examined the prevalence and clinical correlates of major depressive disorder with subthreshold bipolarity compared with pure major depressive disorder in the National Comorbidity Survey Replication (NCS-R)...
  23. pmc Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder
    H J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 16:429-41. 2011
    ..61 × 10(-7)), and stronger evidence when the phenotype was broadened to include bipolar disorder (P=9.96 × 10(-9))...
  24. pmc Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression
    Jie Huang
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 167:1254-63. 2010
    ..Linkage and candidate gene studies have also suggested overlap across schizophrenia, bipolar disorder, and major depressive disorder...
  25. doi Prevalence and characteristics of undiagnosed bipolar disorders in patients with a major depressive episode: the BRIDGE study
    Jules Angst
    The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Arch Gen Psychiatry 68:791-8. 2011
    ..Many patients with major depressive episodes who have an underlying but unrecognized bipolar disorder receive pharmacologic treatment with ineffective regimens that do not include mood stabilizers.
  26. pmc High frequencies of de novo CNVs in bipolar disorder and schizophrenia
    Dheeraj Malhotra
    Beyster Center for Genomics of Psychiatric Diseases, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 72:951-63. 2011
    ..rare copy-number variants (CNVs) contribute to risk for some neuropsychiatric disorders, the role of CNVs in bipolar disorder is unclear...
  27. pmc Mitochondria, oligodendrocytes and inflammation in bipolar disorder: evidence from transcriptome studies points to intriguing parallels with multiple sclerosis
    Christine Konradi
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Neurobiol Dis 45:37-47. 2012
    Gene expression studies of bipolar disorder (BPD) have shown changes in transcriptome profiles in multiple brain regions...
  28. doi Genome wide association studies (GWAS) and copy number variation (CNV) studies of the major psychoses: what have we learnt?
    Kok Wei Lee
    Institute of Mental Health Woodbridge Hospital 10, Buangkok View, Singapore 539747, Singapore
    Neurosci Biobehav Rev 36:556-71. 2012
    Schizophrenia (SZ) and bipolar disorder (BPD) have high heritabilities and are clinically and genetically complex...
  29. pmc Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder
    Michael P Moreau
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854 8095, USA
    Biol Psychiatry 69:188-93. 2011
    ..MicroRNAs (miRNAs) are potent regulators of gene expression with proposed roles in brain development and function. We hypothesized that miRNA expression profiles are altered in individuals with severe psychiatric disorders...
  30. pmc A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder
    M L Phillips
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 13:829, 833-57. 2008
    ..model as a theoretical framework to examine functional neural abnormalities in these neural systems that may predispose to the development of a major psychiatric disorder characterized by severe emotion dysregulation, bipolar disorder.
  31. doi Neural mechanisms of a genome-wide supported psychosis variant
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Science 324:605. 2009
    ..Recently, the first common genetic variant associated on a genome-wide level with schizophrenia and possibly bipolar disorder was discovered in ZNF804A (rs1344706)...
  32. pmc Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
    Hayley B Clay
    Neuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA
    Int J Dev Neurosci 29:311-24. 2011
    b>Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in these disorders...
  33. doi Neurocognitive profiles in bipolar I and bipolar II disorder: differences in pattern and magnitude of dysfunction
    Carmen Simonsen
    Department of Psychiatry, Ulleval University Hospital, and Institute of Psychology, University of Oslo, Oslo, Norway
    Bipolar Disord 10:245-55. 2008
    Studies on neurocognitive functioning in bipolar disorder, reporting deficits in memory, attention, and executive functioning, have primarily focused on bipolar I disorder...
  34. ncbi Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders
    K Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, Saitama, Japan
    Mol Psychiatry 9:406-16. 2004
    We performed the oligonucleotide microarray analysis in bipolar disorder, major depression, schizophrenia, and control subjects using postmortem prefrontal cortices provided by the Stanley Foundation Brain Collection...
  35. doi Anatomy of bipolar disorder and schizophrenia: a meta-analysis
    Ian Ellison-Wright
    Brain Mapping Unit, University of Cambridge, Cambridge, UK
    Schizophr Res 117:1-12. 2010
    ..results have indicated that the two major, classically distinct forms of psychosis - schizophrenia and bipolar disorder - may share causative factors in common...
  36. pmc Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk
    V Moskvina
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 14:252-60. 2009
    ..We have undertaken gene-wide analysis of two GWAS data sets: schizophrenia and bipolar disorder. We performed two forms of analysis, one based on the smallest P-value per gene, the other on a truncated ..
  37. pmc Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder
    Colin A Hodgkinson
    Section of Human Neurogenetics and Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Am J Hum Genet 75:862-72. 2004
    Schizophrenia, schizoaffective disorder, and bipolar disorder are common psychiatric disorders with high heritabilities and variable phenotypes...
  38. ncbi Hippocampal volume and depression: a meta-analysis of MRI studies
    Poul Videbech
    Institute for Basic Psychiatric Research, Department of Biological Psychiatry, Psychiatric Hospital, Aarhus University Hospital, DK 8240 Risskov, Denmark
    Am J Psychiatry 161:1957-66. 2004
    ..The authors performed a systematic review and meta-analysis of volumetric studies of the hippocampus in patients with mood disorders...
  39. ncbi Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes
    M M Ryan
    Cambridge Centre for Neuropsychiatric Research, Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 11:965-78. 2006
    ..of approximately 22,000 mRNA transcripts in post-mortem tissue from two brain regions in patients with bipolar disorder and matched healthy controls...
  40. doi Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors
    M Berk
    Department of Clinical and Biomedical Sciences, University of Melbourne, Victoria 3010, Australia
    Neurosci Biobehav Rev 35:804-17. 2011
    There is now strong evidence of progressive neuropathological processes in bipolar disorder (BD)...
  41. ncbi The heritability of bipolar affective disorder and the genetic relationship to unipolar depression
    Peter McGuffin
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, England
    Arch Gen Psychiatry 60:497-502. 2003
    ..There has been little use of genetic model fitting and no analyses to explore the etiological overlap with unipolar depression (UPD)...
  42. doi Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder
    Lars M Rimol
    Department of Psychiatry, section Vinderen, University of Oslo, Oslo, Norway
    Biol Psychiatry 68:41-50. 2010
    Schizophrenia and bipolar disorder are severe psychiatric diseases with overlapping symptomatology...
  43. ncbi Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia
    Detelina Grozeva
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, UK
    Arch Gen Psychiatry 67:318-27. 2010
    ..The possible involvement of copy number variants (CNVs) in bipolar disorder has received little attention to date.
  44. pmc Temporal lobe and "default" hemodynamic brain modes discriminate between schizophrenia and bipolar disorder
    Vince D Calhoun
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut, USA
    Hum Brain Mapp 29:1265-75. 2008
    Schizophrenia and bipolar disorder are currently diagnosed on the basis of psychiatric symptoms and longitudinal course...
  45. pmc Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD
    Heike Weber
    Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2076-85. 2011
    Recently, several genome-wide association studies (GWAS) on bipolar disorder (BPD) suggested novel risk genes. However, only few of them were followed up and further, the specificity of these genes is even more elusive...
  46. doi Is sex important? Gender differences in bipolar disorder
    Arianna Diflorio
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Heath Park, Cardiff, UK
    Int Rev Psychiatry 22:437-52. 2010
    ..In the case of bipolar disorder, however, it is widely perceived that the reported equal rate of illness in men and women reflects no ..
  47. doi DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder
    W Hennah
    Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU, Scotland
    Mol Psychiatry 14:865-73. 2009
    Disrupted in schizophrenia 1 (DISC1) has been associated with risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism and Asperger syndrome, but apart from in the original translocation family, true ..
  48. doi A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder
    Z Kaminsky
    The Krembil Family Epigenetics Laboratory, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Mol Psychiatry 17:728-40. 2012
    ..fine mapping DNA methylation differences at the human leukocyte antigen (HLA) complex group 9 gene (HCG9) in bipolar disorder (BPD)...
  49. pmc Mania-like behavior induced by disruption of CLOCK
    Kole Roybal
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 104:6406-11. 2007
    Circadian rhythms and the genes that make up the molecular clock have long been implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central transcriptional activator of molecular rhythms, CLOCK, may be ..
  50. pmc The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)
    Agustin Ibanez
    Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology, Favaloro University, Buenos Aires, Argentina
    PLoS ONE 7:e37306. 2012
    Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making...
  51. doi The loudness dependence of the auditory evoked potential (LDAEP) in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controls
    Young Min Park
    Department of Psychiatry, Inje University, Ilsan Paik Hospital, 2240 Daehwa dong, Ilsanseo gu, Goyang 411 706, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 34:313-6. 2010
    Serotonergic dysfunction in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controls was evaluated by measuring the activity of the loudness dependence of the auditory evoked potential (LDAEP).
  52. ncbi Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder Questionnaire
    R M Hirschfeld
    Department of Psychiatry and Behavioral Sciences, Medical Branch, the University of Texas at Galveston 77555 01888, USA
    Am J Psychiatry 157:1873-5. 2000
    Bipolar spectrum disorders, which include bipolar I, bipolar II, and bipolar disorder not otherwise specified, frequently go unrecognized, undiagnosed, and untreated...
  53. doi The functional neuroanatomy of bipolar disorder
    Michael A Cerullo
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Int Rev Psychiatry 21:314-22. 2009
    ..manuscript, research articles using functional magnetic resonance imaging (fMRI) to study adult patients with bipolar disorder were reviewed...
  54. ncbi Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway
    N Matigian
    Queensland Centre for Mental Health Research, Herston, QLD, Australia
    Mol Psychiatry 12:815-25. 2007
    To identify genes dysregulated in bipolar disorder (BD1), we carried out global gene expression profiling using whole-genome microarrays...
  55. doi The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives
    G Lelli-Chiesa
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, UK
    Psychol Med 41:779-88. 2011
    ..is also thought to increase the risk of a number of disorders characterized by affective morbidity including bipolar disorder (BD), major depressive disorder (MDD) and anxiety disorders...
  56. ncbi Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder
    D Cotter
    Department of Psychological Medicine and Neuropathology, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 58:545-53. 2001
    ..In this investigation, we have simultaneously assessed glial cell density and neuronal density and size in the anterior cingulate cortex in schizophrenia, major depressive disorder, and bipolar disorder.
  57. ncbi Brain metabolic alterations in medication-free patients with bipolar disorder
    Stephen R Dager
    Department of Radiology, University of Washington, Seattle 98105, USA
    Arch Gen Psychiatry 61:450-8. 2004
    b>Bipolar disorder (BD) has substantial morbidity and incompletely understood neurobiological underpinnings.
  58. doi Genome-wide association study of bipolar I disorder in the Han Chinese population
    M T M Lee
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Psychiatry 16:548-56. 2011
    ..55 × 10(-5) and P=1.48 × 10(-5), respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder...
  59. doi Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation
    Allison G Harvey
    Sleep and Psychological Disorders Lab, Department of Psychology, University of California, 3210 Tolman Hall, 1650, Berkeley, CA 94720 1650, USA
    Am J Psychiatry 165:820-9. 2008
    Despite advances in the treatment of bipolar disorder, a significant proportion of patients experience disabling symptoms between episodes, and relapse rates are high...
  60. pmc Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    Jonathan Mill
    Krembil Family Epigenetic Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Am J Hum Genet 82:696-711. 2008
    Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia and bipolar disorder. To date, however, few studies have investigated the role of DNA methylation in major psychosis, and none have taken a genome-..
  61. doi The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the treatment of acute bipolar depression
    Heinz Grunze
    Newcastle University, RVI, Division of Psychiatry, Institute of Neuroscience, Newcastle upon Tyne, UK
    World J Biol Psychiatry 11:81-109. 2010
    ..Their purpose is to supply a systematic overview of all scientific evidence pertaining to the treatment of acute bipolar depression in adults...
  62. ncbi The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatients
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 1931, 8032 Zurich, Switzerland
    J Affect Disord 88:217-33. 2005
    ..As such, an instrument for self-assessment of hypomanic symptoms might increase the detection of suspected and of manifest, but under-treated, cases of bipolar disorders...
  63. doi High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides
    Emanuel Schwarz
    Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom
    J Proteome Res 7:4266-77. 2008
    ..lipid levels in the prefrontal cortex (Brodmann area 9) of 45 subjects including 15 schizophrenia and 15 bipolar disorder patients as well as 15 controls samples...
  64. pmc Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 106:7501-6. 2009
    b>Bipolar disorder (BP) is a disabling and often life-threatening disorder that affects approximately 1% of the population worldwide...
  65. ncbi Collaborative care for bipolar disorder: part I. Intervention and implementation in a randomized effectiveness trial
    Mark S Bauer
    Providence Veterans Affairs Medical Center VANC, Rhode Island 02908 4799, USA
    Psychiatr Serv 57:927-36. 2006
    Outcome for bipolar disorder remains suboptimal despite the availability of efficacious treatments...
  66. doi Evidence-based guidelines for treating bipolar disorder: revised second edition--recommendations from the British Association for Psychopharmacology
    G M Goodwin
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychopharmacol 23:346-88. 2009
    The British Association for Psychopharmacology guidelines specify the scope and target of treatment for bipolar disorder. The second version, like the first, is based explicitly on the available evidence and presented, like previous ..
  67. doi The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder
    Roosmarijn C Drexhage
    Department of Immunology, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Expert Rev Neurother 10:59-76. 2010
    This review describes patients with schizophrenia and bipolar disorder. In such patients, a high inflammatory set point of circulating monocytes at the transcriptome level is observed, involving various inflammatory transcripts forming ..
  68. ncbi National trends in the outpatient diagnosis and treatment of bipolar disorder in youth
    Carmen Moreno
    Unidad de Adolescentes, Hospital General Universitario Gregorio Maranon, Servicio do Psiquiatría, Madrid, Spain
    Arch Gen Psychiatry 64:1032-9. 2007
    Although bipolar disorder may have its onset during childhood, little is known about national trends in the diagnosis and management of bipolar disorder in young people.
  69. doi Bipolar depression: overview and commentary
    Ross J Baldessarini
    Harvard Medical School, McLean Hospital, Belmont, MA, USA
    Harv Rev Psychiatry 18:143-57. 2010
    ..Interest in recognizing bipolar depression and seeking more effective, specific, and safer treatments for it are growing...
  70. ncbi The use of antidepressants in bipolar disorder
    Virginio Salvi
    Department of Neuroscience, University of Turin, Italy
    J Clin Psychiatry 69:1307-18. 2008
    Whether or not to use antidepressants in patients with bipolar disorder is a matter of debate. Antidepressant treatment of bipolar depression has been associated with manic switch and cycle acceleration...
  71. doi Premature mortality from general medical illnesses among persons with bipolar disorder: a review
    Babak Roshanaei-Moghaddam
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, USA
    Psychiatr Serv 60:147-56. 2009
    Despite recent evidence that patients with bipolar disorder are at increased risk of premature mortality resulting from general medical disorders, there has been no systematic review of published studies...
  72. doi Asenapine for long-term treatment of bipolar disorder: a double-blind 40-week extension study
    Roger S McIntyre
    Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, ON, Canada
    J Affect Disord 126:358-65. 2010
    ..We report the results of long-term treatment with asenapine in patients with bipolar I disorder...
  73. doi No evidence for excess runs of homozygosity in bipolar disorder
    Anna E Vine
    Centre for Psychiatry, University College London, UK
    Psychiatr Genet 19:165-70. 2009
    ..Of these, four contained or neighboured genes associated with schizophrenia (NOS1AP/UHMK1, ATF2, NSF and PIK3C3)...
  74. ncbi Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 68, CH 8029, Zurich, Switzerland
    J Affect Disord 73:133-46. 2003
    ..to develop and validate criteria for the definition of softer expressions of bipolar-II (BP-II) disorder and hypomania, (3). to demonstrate the prevalence, clinical validity and comorbidity of the entire soft bipolar spectrum...
  75. pmc Enhanced relapse prevention for bipolar disorder--ERP trial. A cluster randomised controlled trial to assess the feasibility of training care coordinators to offer enhanced relapse prevention for bipolar disorder
    Fiona Lobban
    School of Psychological Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    BMC Psychiatry 7:6. 2007
    b>Bipolar Disorder (BD) is a common and severe form of mental illness characterised by repeated relapses of mania or depression. Pharmacotherapy is the main treatment currently offered, but this has only limited effectiveness...
  76. pmc Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the Course and Outcome of Bipolar Youth (COBY) study
    Boris Birmaher
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:795-804. 2009
    ..The authors sought to assess the longitudinal course of youths with bipolar spectrum disorders over a 4-year period...
  77. doi Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Vic, Australia
    J Affect Disord 113:1-20. 2009
    Our aim was to delineate neuropsychological deficits related to genetic susceptibility, illness process and iatrogenic factors in bipolar disorder (BD).
  78. ncbi Reduced expression of human endogenous retrovirus (HERV)-W GAG protein in the cingulate gyrus and hippocampus in schizophrenia, bipolar disorder, and depression
    S Weis
    Laboratory of Brain Research and Neuropathology, Departments of Psychiatry and Pathology, Uniformed Services University of the Health Sciences, and Stanley Medical Research Institute, Bethesda, MD, USA
    J Neural Transm 114:645-55. 2007
    ..anterior cingulate cortex and hippocampal formation of normal controls and of patients with schizophrenia, bipolar disorder and major depression...
  79. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..with bipolar (BP) 1 disorder, 2008 controls drawn from the Systematic Treatment Enhancement Program for Bipolar Disorder and the University College London sample collections with successful genotyping for 372,193 single nucleotide ..
  80. ncbi A randomized trial on the efficacy of group psychoeducation in the prophylaxis of recurrences in bipolar patients whose disease is in remission
    Francesco Colom
    Bipolar Disorders Program, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS Barcelona, Spain
    Arch Gen Psychiatry 60:402-7. 2003
    ..However, there has been a lack of structured, well-designed, blinded, controlled studies demonstrating the efficacy of group psychoeducation to prevent recurrences in patients with bipolar I and II disorder...
  81. ncbi Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial
    John R Geddes
    Oxford Clinical Trials Unit for Mental Illness, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Lancet 375:385-95. 2010
    Lithium carbonate and valproate semisodium are both recommended as monotherapy for prevention of relapse in bipolar disorder, but are not individually fully effective in many patients...
  82. doi Maintenance treatment for patients with bipolar I disorder: results from a north american study of quetiapine in combination with lithium or divalproex (trial 127)
    Trisha Suppes
    3801 Miranda Ave 151 T, Palo Alto, CA 94304, USA
    Am J Psychiatry 166:476-88. 2009
    ..The authors evaluated the efficacy and safety of quetiapine plus lithium or divalproex in the prevention of recurrent mood events in patients with stabilized bipolar I disorder...
  83. ncbi Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing
    Yuan Su
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Biochemistry 43:6899-908. 2004
    Lithium is one of the most widely used mood-stabilizing agents for the treatment of bipolar disorder. Although the underlying mechanism(s) of this mood stabilizer remains controversial, recent evidence linking lithium to neurotrophic/..
  84. ncbi Trends in the treatment of bipolar disorder by outpatient psychiatrists
    Carlos Blanco
    Department of Psychiatry and New York State Psychiatric Institute, Columbia University, New York, NY 10032, USA
    Am J Psychiatry 159:1005-10. 2002
    This study examined recent changes in the prescribing patterns for medications to treat bipolar disorder in office-based psychiatric practice.
  85. doi Ziprasidone monotherapy in bipolar II depression: an open trial
    Michael R Liebowitz
    The Medical Research Network, LLC, New York, NY 10024, USA
    J Affect Disord 118:205-8. 2009
    ....
  86. doi Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder
    L Zhan
    Clinical Developmental Sciences, St George s University of London, Cranmer Terrace, London
    Neuropathol Appl Neurobiol 37:206-19. 2011
    signalling through dopamine receptors is of critical importance in the brain and is implicated in schizophrenia and bipolar disorder, but its underlying molecular mechanisms remain poorly understood.
  87. doi Reporting outcomes in clinical trials for bipolar disorder: a commentary and suggestions for change
    Anabel Martinez-Aran
    Bipolar Disorders Program, IDIBAPS, CIBER SAM, Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Bipolar Disord 10:566-79. 2008
    ..translate efficacy data to evidence-based psychiatric care are needed when evaluating clinical trials for bipolar disorder. Using efficacy studies as illustrations, the authors review and recommend changes in the reporting of ..
  88. ncbi The role of psychotherapy in bipolar disorder
    Sue D Lauder
    Department of Clinical and Biomedical Sciences Barwon Health, University of Melbourne, Geelong, Vic, Australia
    Med J Aust 193:S31-5. 2010
    Adjunctive psychosocial interventions for bipolar disorder target many of the issues that are not addressed by medication alone, including non-adherence, efficacy-effectiveness gap and functionality...
  89. doi White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging
    Jessika E Sussmann
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Bipolar Disord 11:11-8. 2009
    Strong qualitative and quantitative evidence exists of white matter abnormalities in both schizophrenia and bipolar disorder (BD). Diffusion tensor imaging (DTI) studies suggest altered connectivity in both disorders...
  90. pmc Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression
    Ekrem Maloku
    Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 107:4407-11. 2010
    ..This finding suggests that lack of reelin impairs GABAergic Purkinje neuron expression and/or positioning during cerebellar development...
  91. doi Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse
    M Kathleen Holmes
    Research Imaging Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Bipolar Disord 11:33-40. 2009
    Elevated levels of impulsivity and increased risk taking are thought to be core features of both bipolar disorder (BD) and addictive disorders...
  92. ncbi Prepubertal mania: diagnostic differences between US and UK clinicians
    Bernadka Dubicka
    University of Manchester and The Junction Adolescent Unit, Piccadilly, Lancaster LA1 4PW, UK
    Eur Child Adolesc Psychiatry 17:153-61. 2008
    ..To test the hypothesis that US clinicians diagnose prepubertal mania more commonly than UK clinicians...
  93. ncbi Group psychoeducation for stabilised bipolar disorders: 5-year outcome of a randomised clinical trial
    F Colom
    Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic of Barcelona, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Br J Psychiatry 194:260-5. 2009
    ..The long-term efficacy of psychological interventions for bipolar disorders has not been tested...
  94. ncbi Searching genetic risk factors for schizophrenia and bipolar disorder: learn from the past and back to the future
    Maaike Alaerts
    Applied Molecular Genomics Group, Vlaams Instituut voor Biotechnologie Flanders Institute for Biotechnology, Department of Molecular Genetics, University of Antwerp, Antwerp B 2610, Belgium
    Hum Mutat 30:1139-52. 2009
    ..We discuss what can be learned from the past and how this knowledge can be used in future study designs...
  95. pmc Clinical diagnoses in young offspring from eastern Québec multigenerational families densely affected by schizophrenia or bipolar disorder
    M Maziade
    Centre de Recherche Universite Laval Robert Giffard, QC, Canada
    Acta Psychiatr Scand 117:118-26. 2008
    ..sample of multigenerational families of eastern Québec that are densely affected by schizophrenia (SZ) or bipolar disorder (BP) has permitted to look at the rates of DSM diagnoses in the young offspring of a SZ parent (HRSZ) and of ..
  96. doi Efficacy of ziprasidone in dysphoric mania: pooled analysis of two double-blind studies
    S Stahl
    Department of Psychiatry, UCSD, San Diego, CA 92008, USA
    J Affect Disord 122:39-45. 2010
    ..Dysphoric mania is a common and often difficult to treat subset of bipolar mania that is associated with significant depressive symptoms...
  97. pmc Association study of Wnt signaling pathway genes in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 65:785-93. 2008
    The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder.
  98. doi Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1
    Ting Ting Chang
    Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan
    Bipolar Disord 12:102-6. 2010
    Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients.
  99. pmc Bipolar disorder and mechanisms of action of mood stabilizers
    Stanley I Rapoport
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Brain Res Rev 61:185-209. 2009
    b>Bipolar disorder (BD) is a major medical and social burden, whose cause, pathophysiology and treatment are not agreed on...
  100. pmc The genetics of bipolar disorder
    J H Barnett
    Center for Human Genetic Research, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuroscience 164:331-43. 2009
    b>Bipolar disorder is a mood disorder characterized by impairing episodes of mania and depression...

Research Grants106 found, 100 shown here

  1. Molecular Interventions for Bipolar Disorder
    ALAN PAUL KOZIKOWSKI; Fiscal Year: 2010
    ..than 2 million American adults, or about 1 percent of the population age 18 and older in any given year, have bipolar disorder. Current treatments include the so-called "mood stabilizers," lithium and valproic acid...
  2. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Evan Snyder; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): ): Bipolar disorder (BPD) is a neuropsychiatric condition defined by a lifetime of relapsing &remitting manic &depressive episodes...
  3. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..Psychiatric Disorders such as alcohol and other substance abuse disorders, unipolar depression, bipolar disorder and attention-deficit/hyperactivity disorder (ADHD) are amongst the most significant causes of morbidity and ..
  4. Validation of a functional MRI-based reward processing task as a non-invasive too
    Mary Phillips; Fiscal Year: 2009
    ..Psychiatric Disorders such as alcohol and other substance abuse disorders, unipolar depression, bipolar disorder and attention-deficit/hyperactivity disorder (ADHD) are amongst the most significant causes of morbidity and ..
  5. Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Con
    Hilary Blumberg; Fiscal Year: 2009
    ..entitled: Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Contribute to High Risk in Bipolar Disorder. The proposed study addresses a critical gap in knowledge that could have a major impact on progress in ..
  6. Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Con
    Hilary P Blumberg; Fiscal Year: 2010
    ..entitled: Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Contribute to High Risk in Bipolar Disorder. The proposed study addresses a critical gap in knowledge that could have a major impact on progress in ..
  7. Molecular Interventions for Bipolar Disorder
    Alan Kozikowski; Fiscal Year: 2009
    ..than 2 million American adults, or about 1 percent of the population age 18 and older in any given year, have bipolar disorder. Current treatments include the so-called "mood stabilizers," lithium and valproic acid...
  8. Molecular Interventions for Bipolar Disorder
    Alan Kozikowski; Fiscal Year: 2007
    ..than 2 million American adults, or about 1 percent of the population age 18 and older in any given year, have bipolar disorder. Current treatments include the so-called "mood stabilizers," lithium and valproic acid...
  9. Social Cognition and Functioning in Bipolar Disorder
    Michael F Green; Fiscal Year: 2010
    ..It is increasingly clear that recent advances in the treatment of the clinical symptoms of bipolar disorder (BPD) have not improved its functional outcome, which remains disappointing...
  10. Pharmacoepidemiology of Atypical Antipsychotic Drugs
    William V Bobo; Fiscal Year: 2010
    ..long-term goal is a career in academic psychiatry focused on research that improves the care of patients with bipolar disorder. My plan is to conduct epidemiologic studies that clarify the relative safety and effectiveness of ..
  11. Social Cognition and Functioning in Bipolar Disorder
    Michael Green; Fiscal Year: 2009
    ..It is increasingly clear that recent advances in the treatment of the clinical symptoms of bipolar disorder (BPD) have not improved its functional outcome, which remains disappointing...
  12. Brain Mechanisms in Pediatric Bipolar Disorder and Attention Deficit Hyperactivit
    Mani Pavuluri; Fiscal Year: 2009
    ..to RFA-04-MH-102, is to differentiate the alterations in cognitive and affective circuitry in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD) relative to typically developing operations...
  13. Brain Mechanisms in Pediatric Bipolar Disorder and Attention Deficit Hyperactivit
    Mani N Pavuluri; Fiscal Year: 2010
    ..to RFA-04-MH-102, is to differentiate the alterations in cognitive and affective circuitry in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD) relative to typically developing operations...
  14. Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar Disorder
    David Miklowitz; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Bipolar disorder (BD) in youth is associated with significant impairments in functioning, treatment-resistance, and high public health costs...
  15. Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar Disorder
    David Miklowitz; Fiscal Year: 2007
    b>Bipolar disorder (BD) in youth is associated with significant impairments in functioning, treatment-resistance, and high public health costs...
  16. The role of dopaminergic transmission in the development of manic-like behaviors
    SADE MONIQUE SPENCER; Fiscal Year: 2010
    ..provided by applicant): There is a growing body of evidence to suggest that mood disorders, such as bipolar disorder, may be associated with disruptions in circadian rhythms...
  17. Wnt/GSK3/beta Catenin Signaling as a Target for Treatment of Bipolar Disorder
    Rakesh Karmacharya; Fiscal Year: 2010
    ..of the Wnt/GSK3/beta-catenin signaling pathway, which is implicated in the pathophysiology and treatment of bipolar disorder. Recent work by the candidate showed that histone deacetylases (HDACs) play a role in modulation of beta-..
  18. GABAergic and Reelin Deficits in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..subjects with bipolar disorder, major depression, and matched controls...
  19. Sleep Activity Patterns and Temperature in Childhood Onset Bipolar Disorder
    Patricia Murphy; Fiscal Year: 2009
    Sleep and circadian rhythm disturbances are common features of bipolar disorder. Childhood onset bipolar disorder (COBD), in particular, is characterized by symptoms suggestive of altered regulation of sleep and wakefulness...
  20. Genetic Influences on Frontotemporal Connectivity in Bipolar Disorder
    Hilary P Blumberg; Fiscal Year: 2011
    ..in age-related patterns of frontotemporal (FT) connectivity in adolescents and adults with and without bipolar disorder (BD) and the genetic factors that influence them...
  21. Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human Neurons
    JEN PAN; Fiscal Year: 2012
    ..provided by applicant): This is a new R21 application to study in live human neurons the function of a bipolar disorder susceptibility gene encoding a neuronal calcium channel...
  22. Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI
    Amit Anand; Fiscal Year: 2011
    ..major depression) while others suffer from episodes of both depression and the opposite mood state of mania (bipolar disorder or BD)? In the clinical setting, both UD and BD depression (BDD) are difficult to differentiate and can only ..
  23. Estimating Intracellular Lithium in Brain in vivo by 7Li MRS
    Richard Komoroski; Fiscal Year: 2009
    ..by applicant): Lithium (Li) is the treatment of choice for acute mania and for relapse prevention in bipolar disorder. Despite its widespread clinical use and extensive research into its mechanisms of action, there is little ..
  24. INHIBITORY DEFICITS IN HUMAN AND ANIMAL MODELS OF BIPOLAR DISORDER
    WILLIAM contact PERRY; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Bipolar Disorder (BD) is a severe psychiatric illness that is hallmarked by manic and depressive states...
  25. Naltrexone for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2005
    ..b>Bipolar disorder is a severe and persistent psychiatric illness affecting 1.2-1...
  26. OMEGA-3 FATTY ACIDS IN BIPOLAR DISORDER PROPHYLAXIS
    ANDREW STOLL; Fiscal Year: 2001
    ..trial is to assess the efficacy of omega-3 fatty acids (03FA) in preventing recurrence in patients with bipolar disorder, type 1...
  27. OMEGA-3 FATTY ACIDS IN BIPOLAR DISORDER PROPHYLAXIS
    ANDREW STOLL; Fiscal Year: 1999
    ..trial is to assess the efficacy of omega-3 fatty acids (03FA) in preventing recurrence in patients with bipolar disorder, type 1...
  28. OMEGA-3 FATTY ACIDS IN BIPOLAR DISORDER PROPHYLAXIS
    ANDREW STOLL; Fiscal Year: 2000
    ..trial is to assess the efficacy of omega-3 fatty acids (03FA) in preventing recurrence in patients with bipolar disorder, type 1...
  29. OMEGA-3 FATTY ACIDS IN BIPOLAR DISORDER PROPHYLAXIS
    ANDREW STOLL; Fiscal Year: 2002
    ..trial is to assess the efficacy of omega-3 fatty acids (03FA) in preventing recurrence in patients with bipolar disorder, type 1...
  30. Naltrexone for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2006
    ..b>Bipolar disorder is a severe and persistent psychiatric illness affecting 1.2-1...
  31. Endocannabinoid system and inhibition in bipolar disorder
    William Perry; Fiscal Year: 2012
    ..most important modulatory systems in the brain and is known to impact neurobiological factors implicated in Bipolar Disorder (BD), including dopamine (DA), a neurotransmitter associated with mania and cognitive impairments linked to ..
  32. Comparative Effectiveness Study for Bipolar Disorder
    Andrew A Nierenberg; Fiscal Year: 2010
    ..In fact, QTP has become the most commonly prescribed medication for bipolar disorder. This is true in spite of the observation that treatment with SGAs is associated with significant metabolic ..
  33. A Molecular Mechanism for Lithium Action
    Peter Klein; Fiscal Year: 2007
    Lithium is the first line of therapy in the treatment of bipolar disorder yet its mechanism of action in this setting is not known...
  34. A Molecular Mechanism for Lithium Action
    Peter Klein; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Lithium is the first line of therapy in the treatment of bipolar disorder yet its mechanism of action in this setting is not known...
  35. A Molecular Mechanism for Lithium Action
    Peter Klein; Fiscal Year: 2006
    Lithium is the first line of therapy in the treatment of bipolar disorder yet its mechanism of action in this setting is not known...
  36. LORAZEPAM VS PERPHENAZINE--ADJUNCTS TO LITHIUM IN MANIA
    Michael Sernyak; Fiscal Year: 1993
    ....
  37. Efficacy and Safety of Galantamine for Dysfunction in Bipolar Disorder
    DAN VLAD IOSIFESCU; Fiscal Year: 2010
    ..and its associated psychosocial and vocational functional impairments, occurs in many patients with bipolar disorder even when mood symptoms are adequately treated...
  38. Efficacy and Safety of Galantamine for Dysfunction in Bipolar Disorder
    Dan Iosifescu; Fiscal Year: 2009
    ..and its associated psychosocial and vocational functional impairments, occurs in many patients with bipolar disorder even when mood symptoms are adequately treated...
  39. Neuroimaging and Behavioral Biomarkers for ADHD in Children
    Martin H Teicher; Fiscal Year: 2010
    ..Pediatric bipolar disorder is an even more controversial diagnosis, associated with widespread disparity between experts in criteria and ..
  40. Neuroimaging and Behavioral Biomarkers for ADHD in Children
    Martin Teicher; Fiscal Year: 2009
    ..Pediatric bipolar disorder is an even more controversial diagnosis, associated with widespread disparity between experts in criteria and ..
  41. 31P magnetization transfer study of bipolar disorder
    Chun Zuo; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Magnetization Transfer Study of Bipolar Disorder Abstract The disease mechanism of bipolar disorder remains largely unknown...
  42. 31P magnetization transfer study of bipolar disorder
    Chun S Zuo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Magnetization Transfer Study of Bipolar Disorder Abstract The disease mechanism of bipolar disorder remains largely unknown...
  43. DNA METHYLOME ANALYSIS IN BIPOLAR DISORDER
    ART PETRONIS; Fiscal Year: 2010
    Epigenetic misregulation is consistent with various non-Mendelian features of bipolar disorder (BPD), such as the discordance of identical twins, significant fluctuations in disease course, sex- and parental origin- effects, and the ..
  44. Development of a Personalized Real-Time Intervention for Bipolar Disorder
    Colin A Depp; Fiscal Year: 2010
    ..utility of a new personalized smart-phone intervention to enhance illness self-management in people with bipolar disorder. Bipolar disorder is a heterogeneous fluctuating condition and a leading source of disability...
  45. Glutamine and Glutamate in Children and Adolescents with Bipolar Disorder
    Constance M Moore; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Bipolar Disorder (BPD) may be as common among youths as it is among adults. The lifetime prevalence for Bipolar Disorder in adults ranges from 0.6% to 1.1%...
  46. DNA METHYLOME ANALYSIS IN BIPOLAR DISORDER
    ART PETRONIS; Fiscal Year: 2009
    Epigenetic misregulation is consistent with various non-Mendelian features of bipolar disorder (BPD), such as the discordance of identical twins, significant fluctuations in disease course, sex- and parental origin- effects, and the ..
  47. Glutamine and Glutamate in Children and Adolescents with Bipolar Disorder
    CONSTANCE MOORE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Bipolar Disorder (BPD) may be as common among youths as it is among adults. The lifetime prevalence for Bipolar Disorder in adults ranges from 0.6% to 1.1%...
  48. Quetiapine for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2009
    b>Bipolar disorder is a severe, persistent, and common psychiatric illness that is associated with a staggering 46% lifetime prevalence of alcohol-related disorders...
  49. Quetiapine for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2010
    b>Bipolar disorder is a severe, persistent, and common psychiatric illness that is associated with a staggering 46% lifetime prevalence of alcohol-related disorders...
  50. Quetiapine for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2007
    b>Bipolar disorder is a severe, persistent, and common psychiatric illness that is associated with a staggering 46% lifetime prevalence of alcohol-related disorders...
  51. Quetiapine for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2007
    b>Bipolar disorder is a severe, persistent, and common psychiatric illness that is associated with a staggering 46% lifetime prevalence of alcohol-related disorders...
  52. Quetiapine for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2009
    b>Bipolar disorder is a severe, persistent, and common psychiatric illness that is associated with a staggering 46% lifetime prevalence of alcohol-related disorders...
  53. Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for Mania
    Melissa Delbello; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Adolescent offspring of parents with bipolar disorder, particularly those with prominent depressive symptoms, have an elevated risk of developing mania, and by definition bipolar I disorder, compared ..
  54. VALPROATE VERSUS LITHIUM IN BIPOLAR RAPID CYCLING
    Joseph Calabrese; Fiscal Year: 1999
    Although lithium remains the treatment of choice for bipolar disorder, only 6O-80% of classic bipolar patients have a satisfactory clinical response...
  55. Genetic Predictors of Lithium Response in Bipolar Disorder
    John R Kelsoe; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Project Abstract Bipolar Disorder is a major psychiatric disorder characterized by alternation between the extreme mood states of mania and depression...
  56. Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for Mania
    Robert K McNamara; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Adolescent offspring of parents with bipolar disorder, particularly those with prominent depressive symptoms, have an elevated risk of developing mania, and by definition bipolar I disorder, compared ..
  57. Glucogen Synthase Kinase 3beta and Bipolar Disorder
    Xiaohua Li; Fiscal Year: 2003
    ..regulation of glycogen synthase kinase 3beta, its modulation by mood stabilizers and its potential role in bipolar disorder. The five-year plans to enable the candidate to develop into an independent psychiatric investigator to ..
  58. Glucogen Synthase Kinase 3beta and Bipolar Disorder
    Xiaohua Li; Fiscal Year: 2004
    ..regulation of glycogen synthase kinase 3beta, its modulation by mood stabilizers and its potential role in bipolar disorder. The five-year plans to enable the candidate to develop into an independent psychiatric investigator to ..
  59. Glucogen Synthase Kinase 3beta and Bipolar Disorder
    Xiaohua Li; Fiscal Year: 2005
    ..regulation of glycogen synthase kinase 3beta, its modulation by mood stabilizers and its potential role in bipolar disorder. The five-year plans to enable the candidate to develop into an independent psychiatric investigator to ..
  60. Glucogen Synthase Kinase 3beta and Bipolar Disorder
    Xiaohua Li; Fiscal Year: 2006
    ..regulation of glycogen synthase kinase 3beta, its modulation by mood stabilizers and its potential role in bipolar disorder. The five-year plans to enable the candidate to develop into an independent psychiatric investigator to ..
  61. Glucogen Synthase Kinase 3beta and Bipolar Disorder
    Xiaohua Li; Fiscal Year: 2007
    ..regulation of glycogen synthase kinase 3beta, its modulation by mood stabilizers and its potential role in bipolar disorder. The five-year plans to enable the candidate to develop into an independent psychiatric investigator to ..
  62. Valproate Efficacy in Cocaine-Bipolar Comorbidity
    Ihsan Salloum; Fiscal Year: 2006
    ..the efficacy of a promising pharmacological approach for the treatment of comorbid cocaine dependence and bipolar disorder. We propose a randomized, double blind, placebo-controlled, 12-week trial, to test the efficacy of Divalproex ..
  63. Valproate Efficacy in Cocaine-Bipolar Comorbidity
    Ihsan Salloum; Fiscal Year: 2005
    ..the efficacy of a promising pharmacological approach for the treatment of comorbid cocaine dependence and bipolar disorder. We propose a randomized, double blind, placebo-controlled, 12-week trial, to test the efficacy of Divalproex ..
  64. Valproate Efficacy in Cocaine-Bipolar Comorbidity
    Ihsan Salloum; Fiscal Year: 2009
    ..the efficacy of a promising pharmacological approach for the treatment of comorbid cocaine dependence and bipolar disorder. We propose a randomized, double blind, placebo-controlled, 12-week trial, to test the efficacy of Divalproex ..
  65. Reducing Medical Risks in Individuals with Bipolar Disorder
    David Kupfer; Fiscal Year: 2009
    ..aim of this project is to understand whether it is possible to reduce medical risk factors in adults with bipolar disorder and, in doing so, to improve psychiatric and functional outcomes...
  66. PROTON MRSI STUDIES OF BIPOLAR DISORDER
    Perry Renshaw; Fiscal Year: 1999
    ..In pilot studies of individuals with bipolar disorder, we have used 1H MRSI to evaluate brain cytosolic choline levels and, more recently, myo-inositol levels...
  67. PROTON MRSI STUDIES OF BIPOLAR DISORDER
    Perry Renshaw; Fiscal Year: 2001
    ..In pilot studies of individuals with bipolar disorder, we have used 1H MRSI to evaluate brain cytosolic choline levels and, more recently, myo-inositol levels...
  68. Neurophysiology of Working Memory in Bipolar Disorder
    Caleb Adler; Fiscal Year: 2003
    ..Caleb M. Adler's developing expertise in neuroimaging and bipolar disorder. Bipolar disorder is a common psychiatric illness accompanied by severe morbidity and mortality...
  69. Neurophysiology of Working Memory in Bipolar Disorder
    Caleb Adler; Fiscal Year: 2007
    ..Caleb M. Adler's developing expertise in neuroimaging and bipolar disorder. Bipolar disorder is a common psychiatric illness accompanied by severe morbidity and mortality...
  70. PROTON MRSI STUDIES OF BIPOLAR DISORDER
    Perry Renshaw; Fiscal Year: 2000
    ..In pilot studies of individuals with bipolar disorder, we have used 1H MRSI to evaluate brain cytosolic choline levels and, more recently, myo-inositol levels...
  71. Neurophysiology of Working Memory in Bipolar Disorder
    Caleb Adler; Fiscal Year: 2004
    ..Caleb M. Adler's developing expertise in neuroimaging and bipolar disorder. Bipolar disorder is a common psychiatric illness accompanied by severe morbidity and mortality...
  72. Neurophysiology of Working Memory in Bipolar Disorder
    Caleb Adler; Fiscal Year: 2005
    ..Caleb M. Adler's developing expertise in neuroimaging and bipolar disorder. Bipolar disorder is a common psychiatric illness accompanied by severe morbidity and mortality...
  73. Neurophysiology of Working Memory in Bipolar Disorder
    Caleb Adler; Fiscal Year: 2006
    ..Caleb M. Adler's developing expertise in neuroimaging and bipolar disorder. Bipolar disorder is a common psychiatric illness accompanied by severe morbidity and mortality...
  74. Genetic Linkage Studies in Bipolar Disorder Families
    Elliot Gershon; Fiscal Year: 2005
    ..Johns Hopkins, the University of Chicago, and the National Institute of Mental Health--that has developed a bipolar disorder family resource that has proven to be uniquely valuable in testing clinically based hypotheses about the ..
  75. Genetic Linkage Studies in Bipolar Disorder Families
    Elliot Gershon; Fiscal Year: 2006
    ..Johns Hopkins, the University of Chicago, and the National Institute of Mental Health--that has developed a bipolar disorder family resource that has proven to be uniquely valuable in testing clinically based hypotheses about the ..
  76. Genetic Linkage Studies in Bipolar Disorder Families
    Elliot Gershon; Fiscal Year: 2007
    ..Johns Hopkins, the University of Chicago, and the National Institute of Mental Health--that has developed a bipolar disorder family resource that has proven to be uniquely valuable in testing clinically based hypotheses about the ..
  77. Genetic Linkage Studies in Bipolar Disorder Families
    Elliot Gershon; Fiscal Year: 2009
    ..Johns Hopkins, the University of Chicago, and the National Institute of Mental Health--that has developed a bipolar disorder family resource that has proven to be uniquely valuable in testing clinically based hypotheses about the ..
  78. MRI/MRSI Studies of Bipolar Treatment Response
    Perry Renshaw; Fiscal Year: 2005
    ..dysfunction (increased gray matter lactate and glutamate/glutamine/GABA (Glx)) in untreated patients with bipolar disorder; (2) measured changes toward normal values in brain Glx were associated with lithium treatment, but not ..
  79. International Cohort Collection for Bipolar Disorder
    Jordan Smoller; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Bipolar disorder (BPD) is a major public health priority, responsible for a vast burden of disability, personal suffering, and economic cost...
  80. MRI/MRSI Studies of Bipolar Treatment Response
    Perry Renshaw; Fiscal Year: 2006
    ..dysfunction (increased gray matter lactate and glutamate/glutamine/GABA (Glx)) in untreated patients with bipolar disorder; (2) measured changes toward normal values in brain Glx were associated with lithium treatment, but not ..
  81. MRI/MRSI Studies of Bipolar Treatment Response
    Perry Renshaw; Fiscal Year: 2009
    ..dysfunction (increased gray matter lactate and glutamate/glutamine/GABA (Glx)) in untreated patients with bipolar disorder;(2) measured changes toward normal values in brain Glx were associated with lithium treatment, but not ..
  82. MRS Studies of Glutamate and GABA in Bipolar Dissorder
    Dost Ongur; Fiscal Year: 2009
    ..Patient-Oriented Research Career Development Award application entitled "MRS Studies of Glutamate and GABA in Bipolar Disorder"...
  83. MRI/MRSI Studies of Bipolar Treatment Response
    Perry Renshaw; Fiscal Year: 2007
    ..dysfunction (increased gray matter lactate and glutamate/glutamine/GABA (Glx)) in untreated patients with bipolar disorder; (2) measured changes toward normal values in brain Glx were associated with lithium treatment, but not ..
  84. Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Mania
    Caleb Adler; Fiscal Year: 2007
    ....
  85. Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Mania
    Caleb M Adler; Fiscal Year: 2010
    ....
  86. Neurofunctional and Neurochemical Markers of Treatment Response in Bipolar Mania
    Caleb Adler; Fiscal Year: 2009
    ....
  87. RESEARCH TRAINING IN JUVENILE BIPOLAR DISORDER
    Pablo Davanzo; Fiscal Year: 2002
    ..a program of career development and research in psychopharmacology and neuroimaging of juveniles with bipolar disorder. A focus of this program will be a clinical trial with a mood-stabilizer (divalproex sodium) in a group of ..
  88. RESEARCH TRAINING IN JUVENILE BIPOLAR DISORDER
    Pablo Davanzo; Fiscal Year: 2000
    ..a program of career development and research in psychopharmacology and neuroimaging of juveniles with bipolar disorder. A focus of this program will be a clinical trial with a mood-stabilizer (divalproex sodium) in a group of ..
  89. ACUTE MANIA--HALOPERIDOL DOSE AND LORAZEPAM AUGMENTATION
    James Chou; Fiscal Year: 1992
    ..6) Li increases HAL side effects. As a secondary hypothesis, if HAL 25mg/d produces greater clinical improvement than HAL 5mg/d then, 7) Any advantage of HAL 25mg/d (alone) over HAL 5mg/d (alone) is made up by LZP augmentation...
  90. ACUTE MANIA--HALOPERIDOL DOSE AND LORAZEPAM AUGMENTATION
    James Chou; Fiscal Year: 1993
    ..6) Li increases HAL side effects. As a secondary hypothesis, if HAL 25mg/d produces greater clinical improvement than HAL 5mg/d then, 7) Any advantage of HAL 25mg/d (alone) over HAL 5mg/d (alone) is made up by LZP augmentation...
  91. RESEARCH TRAINING IN JUVENILE BIPOLAR DISORDER
    Pablo Davanzo; Fiscal Year: 1999
    ..a program of career development and research in psychopharmacology and neuroimaging of juveniles with bipolar disorder. A focus of this program will be a clinical trial with a mood-stabilizer (divalproex sodium) in a group of ..
  92. MRSI of Frontosubcortical Circuits in Bipolar Disorder
    RAYMOND DEICKEN; Fiscal Year: 2002
    DESCRIPTION: (provided by applicant) Developing evidence strongly suggests that bipolar disorder involves localized abnormalities in specific brain structures that participate in fronto-limbic-subcortical circuits regulating mood...
  93. MRSI of Frontosubcortical Circuits in Bipolar Disorder
    RAYMOND DEICKEN; Fiscal Year: 2001
    DESCRIPTION: (provided by applicant) Developing evidence strongly suggests that bipolar disorder involves localized abnormalities in specific brain structures that participate in fronto-limbic-subcortical circuits regulating mood...
  94. MRSI of Frontosubcortical Circuits in Bipolar Disorder
    RAYMOND DEICKEN; Fiscal Year: 2004
    DESCRIPTION: (provided by applicant) Developing evidence strongly suggests that bipolar disorder involves localized abnormalities in specific brain structures that participate in fronto-limbic-subcortical circuits regulating mood...
  95. MRSI of Frontosubcortical Circuits in Bipolar Disorder
    RAYMOND DEICKEN; Fiscal Year: 2003
    DESCRIPTION: (provided by applicant) Developing evidence strongly suggests that bipolar disorder involves localized abnormalities in specific brain structures that participate in fronto-limbic-subcortical circuits regulating mood...
  96. Psychosocial Treatment for Pediatric Bipolar Disorder
    AMY ELIZABETH WEST; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Pediatric bipolar disorder (PBD) is a severe illness that has devastating consequences for affected children and families...
  97. Psychosocial Treatment for Pediatric Bipolar Disorder
    AMY WEST; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Pediatric bipolar disorder (PBD) is a severe illness that has devastating consequences for affected children and families...
  98. Psychosocial Treatment for Pediatric Bipolar Disorder
    AMY WEST; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Pediatric bipolar disorder (PBD) is a severe illness that has devastating consequences for affected children and families...
  99. Psychiatric Illness: Multigene Expression Classification
    JAMES CLELLAND; Fiscal Year: 2004
    ..proposal is designed to produce data for the development of a biological classification of schizophrenia and bipolar disorder, based on high density microarray measurements of transcribed white blood cell (leukocyte) mRNA...
  100. Psychiatric Illness: Multigene Expression Classification
    JAMES CLELLAND; Fiscal Year: 2005
    ..proposal is designed to produce data for the development of a biological classification of schizophrenia and bipolar disorder, based on high density microarray measurements of transcribed white blood cell (leukocyte) mRNA...
  101. Early Detection of Risk Factors for Bipolar Mania
    Barbara Cornblatt; Fiscal Year: 2009
    ..e., pre-manic) phase of adult onset bipolar disorder. Pilot work is considered essential for demonstrating the viability of the prodromal concept in bipolar ..