bipolar disorder

Summary

Summary: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.

Top Publications

  1. pmc Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    Manuel A R Ferreira
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:1056-8. 2008
  2. pmc Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    SHAUN M PURCELL
    Nature 460:748-52. 2009
  3. pmc Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    Emma L Dempster
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Hum Mol Genet 20:4786-96. 2011
  4. ncbi Identification of loci associated with schizophrenia by genome-wide association and follow-up
    Michael C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 40:1053-5. 2008
  5. pmc Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder
    Peter Holmans
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Heath Park, CF23 6BQ Cardiff, UK
    Am J Hum Genet 85:13-24. 2009
  6. ncbi After GWAS: searching for genetic risk for schizophrenia and bipolar disorder
    Elliot S Gershon
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, USA
    Am J Psychiatry 168:253-6. 2011
  7. pmc Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative
    Kathleen R Merikangas
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 68:241-51. 2011
  8. pmc Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder
    Sven Cichon
    Institute of Neuroscience and Medicine INM 1, Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, Juelich, Germany
    Am J Hum Genet 88:372-81. 2011
  9. pmc Genome-wide association study of bipolar disorder in European American and African American individuals
    E N Smith
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, CA, USA
    Mol Psychiatry 14:755-63. 2009
  10. pmc High frequencies of de novo CNVs in bipolar disorder and schizophrenia
    Dheeraj Malhotra
    Beyster Center for Genomics of Psychiatric Diseases, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 72:951-63. 2011

Detail Information

Publications377 found, 100 shown here

  1. pmc Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    Manuel A R Ferreira
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:1056-8. 2008
    To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G)...
  2. pmc Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    SHAUN M PURCELL
    Nature 460:748-52. 2009
    ..We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases.
  3. pmc Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    Emma L Dempster
    MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Hum Mol Genet 20:4786-96. 2011
    Studies of the major psychoses, schizophrenia (SZ) and bipolar disorder (BD), have traditionally focused on genetic and environmental risk factors, although more recent work has highlighted an additional role for epigenetic processes in ..
  4. ncbi Identification of loci associated with schizophrenia by genome-wide association and follow-up
    Michael C O'Donovan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 40:1053-5. 2008
    ..Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).
  5. pmc Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder
    Peter Holmans
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Heath Park, CF23 6BQ Cardiff, UK
    Am J Hum Genet 85:13-24. 2009
    ..The method was also applied to a meta-analysis of bipolar disorder, and it implicated the modulation of transcription and cellular activity, including that which occurs via ..
  6. ncbi After GWAS: searching for genetic risk for schizophrenia and bipolar disorder
    Elliot S Gershon
    Department of Psychiatry and Behavioral Neuroscience, University of Chicago, USA
    Am J Psychiatry 168:253-6. 2011
    ..Study groups even larger than the 10,000 subjects in current meta-analyses would be required, but the outcomes may lead to resolution of our current dilemma in common diseases: Where is the missing heritability?..
  7. pmc Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative
    Kathleen R Merikangas
    National Institute of Mental Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 68:241-51. 2011
    ..There is limited information on the prevalence and correlates of bipolar spectrum disorder in international population-based studies using common methods...
  8. pmc Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder
    Sven Cichon
    Institute of Neuroscience and Medicine INM 1, Structural and Functional Organization of the Brain, Genomic Imaging, Research Center Juelich, Juelich, Germany
    Am J Hum Genet 88:372-81. 2011
    We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder...
  9. pmc Genome-wide association study of bipolar disorder in European American and African American individuals
    E N Smith
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, CA, USA
    Mol Psychiatry 14:755-63. 2009
    To identify bipolar disorder (BD) genetic susceptibility factors, we conducted two genome-wide association (GWA) studies: one involving a sample of individuals of European ancestry (EA; n=1001 cases; n=1033 controls), and one involving a ..
  10. pmc High frequencies of de novo CNVs in bipolar disorder and schizophrenia
    Dheeraj Malhotra
    Beyster Center for Genomics of Psychiatric Diseases, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 72:951-63. 2011
    ..rare copy-number variants (CNVs) contribute to risk for some neuropsychiatric disorders, the role of CNVs in bipolar disorder is unclear...
  11. ncbi Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries
    Hywel J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 20:387-91. 2011
    ..studies point strongly to a partial overlap in the genes that contribute susceptibility to schizophrenia and bipolar disorder (BD)...
  12. pmc The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia
    E K Green
    Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 15:1016-22. 2010
    ..CACNA1C, the gene encoding the α-1C subunit of the L-type voltage-gated calcium channel) with the risk of bipolar disorder (BD) has recently been reported in a meta-analysis of three genome-wide association studies of BD, including ..
  13. ncbi Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression
    Natalia S Lawrence
    Section of Neuroscience and Emotion, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 55:578-87. 2004
    b>Bipolar disorder (BD) is characterised by abnormalities in mood and emotional processing, but the neural correlates of these, their relationship to depressive symptoms, and the similarities with deficits in major depressive disorder (MDD) ..
  14. pmc Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
    Neurosci Biobehav Rev 33:699-771. 2009
    Both major depressive disorder and bipolar disorder are the subject of a voluminous imaging and genetics literature...
  15. ncbi Prevalence and characteristics of undiagnosed bipolar disorders in patients with a major depressive episode: the BRIDGE study
    Jules Angst
    The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Arch Gen Psychiatry 68:791-8. 2011
    ..Many patients with major depressive episodes who have an underlying but unrecognized bipolar disorder receive pharmacologic treatment with ineffective regimens that do not include mood stabilizers.
  16. ncbi A quantitative meta-analysis of fMRI studies in bipolar disorder
    Chi Hua Chen
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge GlaxoSmithKline Clinical Unit Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Bipolar Disord 13:1-15. 2011
    ..fMRI) has been widely used to identify state and trait markers of brain abnormalities associated with bipolar disorder (BD)...
  17. pmc Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
    Paul Lichtenstein
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Lancet 373:234-9. 2009
    Whether schizophrenia and bipolar disorder are the clinical outcomes of discrete or shared causative processes is much debated in psychiatry...
  18. ncbi Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder
    Matthew J Kempton
    Department of Neuroimaging, PO89, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 68:675-90. 2011
    Although differences in clinical characteristics exist between major depressive disorder (MDD) and bipolar disorder (BD), consistent structural brain abnormalities that distinguish the disorders have not been identified.
  19. pmc Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02178, USA
    Proc Natl Acad Sci U S A 104:10164-9. 2007
    GABAergic dysfunction is present in the hippocampus in schizophrenia (SZ) and bipolar disorder (BD). The trisynaptic pathway was "deconstructed" into various layers of sectors CA3/2 and CA1 and gene expression profiling performed...
  20. ncbi Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
    Odette L J Peerbooms
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University, Maastricht, The Netherlands
    Brain Behav Immun 25:1530-43. 2011
    ..size 29,502) and A1298C (sample size 7934), and the major psychiatric disorders (i) schizophrenia (SZ), (ii) bipolar disorder (BPD), and (iii) unipolar depressive disorder (UDD)...
  21. ncbi The heritability of bipolar affective disorder and the genetic relationship to unipolar depression
    Peter McGuffin
    Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, England
    Arch Gen Psychiatry 60:497-502. 2003
    ..There has been little use of genetic model fitting and no analyses to explore the etiological overlap with unipolar depression (UPD)...
  22. ncbi Neural mechanisms of a genome-wide supported psychosis variant
    Christine Esslinger
    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, J5, 68159 Mannheim, Germany
    Science 324:605. 2009
    ..Recently, the first common genetic variant associated on a genome-wide level with schizophrenia and possibly bipolar disorder was discovered in ZNF804A (rs1344706)...
  23. pmc Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder
    Chi Tso Chiu
    Molecular Neurobiology Section, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Pharmacol Rev 65:105-42. 2013
    The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe mental illness arising from complex interactions between genes and environment that drive deficits in cellular plasticity ..
  24. pmc Circadian genes, rhythms and the biology of mood disorders
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Pharmacol Ther 114:222-32. 2007
    ..have suggested that abnormalities in circadian rhythms may underlie the development of mood disorders such as bipolar disorder (BPD), major depression and seasonal affective disorder (SAD)...
  25. ncbi Excess mortality in bipolar and unipolar disorder in Sweden
    U Osby
    Department of Clinical Neuroscience, Karolinska Institutet, Karolinska sjukhuset S4, S 171 76 Stockholm, Sweden
    Arch Gen Psychiatry 58:844-50. 2001
    ..However, there has been no population-based study of mortality of patients followed up from the onset of the illness...
  26. ncbi Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission
    Kathleen Askland
    Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
    Hum Genet 125:63-79. 2009
    Despite known heritability, the complex genetic architecture of bipolar disorder (likely including trait, locus and allelic heterogeneity, as well as genetic interactions) has confounded genetic discovery for many years...
  27. ncbi Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis
    Marc De Hert
    University Psychiatric Centre, Catholic University Leuven, Kortenberg, Belgium
    CNS Drugs 26:733-59. 2012
    ..the past 2 decades generated considerable optimism that better antipsychotic treatments for schizophrenia and bipolar disorder were possible...
  28. pmc Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients
    Meredith G Banigan
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 8:e48814. 2013
    ..We hypothesized that exosomal miRNA expression in brains of patients diagnosed with schizophrenia (SZ) and bipolar disorder (BD) might differ from controls, reflecting either disease-specific or common aberrations in SZ and BD ..
  29. pmc Treatment of bipolar disorder
    John R Geddes
    Department of Psychiatry, University of Oxford, Oxford, UK
    Lancet 381:1672-82. 2013
    We review recent developments in the acute and long-term treatment of bipolar disorder and identify promising future routes to therapeutic innovation. Overall, advances in drug treatment remain quite modest...
  30. pmc Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients
    J S Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Transl Psychiatry 2:e132. 2012
    Alzheimer's disease (AD) and bipolar disorder (BD) are progressive brain disorders...
  31. ncbi Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Vic, Australia
    J Affect Disord 113:1-20. 2009
    Our aim was to delineate neuropsychological deficits related to genetic susceptibility, illness process and iatrogenic factors in bipolar disorder (BD).
  32. ncbi Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 15:1-44. 2013
    The Canadian Network for Mood and Anxiety Treatments published guidelines for the management of bipolar disorder in 2005, with updates in 2007 and 2009...
  33. pmc Autoimmune diseases, bipolar disorder, and non-affective psychosis
    William W Eaton
    Department of Mental Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Bipolar Disord 12:638-46. 2010
    Clinic-based studies of immune function, as well as comorbidity of autoimmune diseases, bipolar disorder, and schizophrenia, suggest a possible autoimmune etiology...
  34. pmc Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants
    E R Gamazon
    Department of Medicine, University of Chicago, Chicago, 60607 7173, USA
    Mol Psychiatry 18:340-6. 2013
    We conducted a systematic study of top susceptibility variants from a genome-wide association (GWA) study of bipolar disorder to gain insight into the functional consequences of genetic variation influencing disease risk...
  35. ncbi Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors
    M Berk
    Department of Clinical and Biomedical Sciences, University of Melbourne, Victoria 3010, Australia
    Neurosci Biobehav Rev 35:804-17. 2011
    There is now strong evidence of progressive neuropathological processes in bipolar disorder (BD)...
  36. pmc Mitochondria, oligodendrocytes and inflammation in bipolar disorder: evidence from transcriptome studies points to intriguing parallels with multiple sclerosis
    Christine Konradi
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Neurobiol Dis 45:37-47. 2012
    Gene expression studies of bipolar disorder (BPD) have shown changes in transcriptome profiles in multiple brain regions...
  37. pmc Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder
    H J Williams
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 16:429-41. 2011
    ..61 × 10(-7)), and stronger evidence when the phenotype was broadened to include bipolar disorder (P=9.96 × 10(-9))...
  38. pmc Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression
    Jie Huang
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, and Psychiatric Genetics Program in Mood and Anxiety Disorders, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 167:1254-63. 2010
    ..Linkage and candidate gene studies have also suggested overlap across schizophrenia, bipolar disorder, and major depressive disorder...
  39. pmc A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder
    M L Phillips
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 13:829, 833-57. 2008
    ..model as a theoretical framework to examine functional neural abnormalities in these neural systems that may predispose to the development of a major psychiatric disorder characterized by severe emotion dysregulation, bipolar disorder.
  40. ncbi Impaired verbal memory in young adults with unipolar and bipolar depression
    Daniel F Hermens
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
    Early Interv Psychiatry 4:227-33. 2010
    ..Specifically, deficits in verbal memory have been linked to depression in young people. This study examined whether young adults with unipolar compared with bipolar depression showed similar neurocognitive deficits...
  41. ncbi Genome wide association studies (GWAS) and copy number variation (CNV) studies of the major psychoses: what have we learnt?
    Kok Wei Lee
    Institute of Mental Health Woodbridge Hospital 10, Buangkok View, Singapore 539747, Singapore
    Neurosci Biobehav Rev 36:556-71. 2012
    Schizophrenia (SZ) and bipolar disorder (BPD) have high heritabilities and are clinically and genetically complex...
  42. pmc Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
    Hayley B Clay
    Neuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA
    Int J Dev Neurosci 29:311-24. 2011
    b>Bipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in these disorders...
  43. ncbi Neurocognitive profiles in bipolar I and bipolar II disorder: differences in pattern and magnitude of dysfunction
    Carmen Simonsen
    Department of Psychiatry, Ulleval University Hospital, and Institute of Psychology, University of Oslo, Oslo, Norway
    Bipolar Disord 10:245-55. 2008
    Studies on neurocognitive functioning in bipolar disorder, reporting deficits in memory, attention, and executive functioning, have primarily focused on bipolar I disorder...
  44. ncbi Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2009
    Lakshmi N Yatham
    Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada
    Bipolar Disord 11:225-55. 2009
    The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines for the management of bipolar disorder in 2005, with a 2007 update...
  45. pmc Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group
    Carmen Simonsen
    Department of Psychology, University of Oslo, 0317 Oslo, Norway
    Schizophr Bull 37:73-83. 2011
    ..We asked whether neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends more on history of psychosis than diagnostic category or subtype...
  46. ncbi GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder
    F M Benes
    Laboratory for Structural Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 25:1-27. 2001
    ..evidence that a defect of GABAergic neurotransmission probably plays a role in both schizophrenia and bipolar disorder. Many now believe that such a disturbance may be related to a perturbation of early development, one that may ..
  47. pmc A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response
    Michael J McCarthy
    Veterans Affairs San Diego Healthcare System, San Diego, California, United Sates of America
    PLoS ONE 7:e32091. 2012
    Circadian rhythm abnormalities in bipolar disorder (BD) have led to a search for genetic abnormalities in circadian "clock genes" associated with BD...
  48. ncbi Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders
    K Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, Saitama, Japan
    Mol Psychiatry 9:406-16. 2004
    We performed the oligonucleotide microarray analysis in bipolar disorder, major depression, schizophrenia, and control subjects using postmortem prefrontal cortices provided by the Stanley Foundation Brain Collection...
  49. pmc Temporal lobe and "default" hemodynamic brain modes discriminate between schizophrenia and bipolar disorder
    Vince D Calhoun
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut, USA
    Hum Brain Mapp 29:1265-75. 2008
    Schizophrenia and bipolar disorder are currently diagnosed on the basis of psychiatric symptoms and longitudinal course...
  50. ncbi Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia
    Detelina Grozeva
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, UK
    Arch Gen Psychiatry 67:318-27. 2010
    ..The possible involvement of copy number variants (CNVs) in bipolar disorder has received little attention to date.
  51. ncbi Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder
    Lars M Rimol
    Department of Psychiatry, section Vinderen, University of Oslo, Oslo, Norway
    Biol Psychiatry 68:41-50. 2010
    Schizophrenia and bipolar disorder are severe psychiatric diseases with overlapping symptomatology...
  52. pmc Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder
    Colin A Hodgkinson
    Section of Human Neurogenetics and Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA
    Am J Hum Genet 75:862-72. 2004
    Schizophrenia, schizoaffective disorder, and bipolar disorder are common psychiatric disorders with high heritabilities and variable phenotypes...
  53. ncbi Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes
    M M Ryan
    Cambridge Centre for Neuropsychiatric Research, Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 11:965-78. 2006
    ..of approximately 22,000 mRNA transcripts in post-mortem tissue from two brain regions in patients with bipolar disorder and matched healthy controls...
  54. ncbi Hippocampal volume and depression: a meta-analysis of MRI studies
    Poul Videbech
    Institute for Basic Psychiatric Research, Department of Biological Psychiatry, Psychiatric Hospital, Aarhus University Hospital, DK 8240 Risskov, Denmark
    Am J Psychiatry 161:1957-66. 2004
    ..The authors performed a systematic review and meta-analysis of volumetric studies of the hippocampus in patients with mood disorders...
  55. pmc Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk
    V Moskvina
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Mol Psychiatry 14:252-60. 2009
    ..We have undertaken gene-wide analysis of two GWAS data sets: schizophrenia and bipolar disorder. We performed two forms of analysis, one based on the smallest P-value per gene, the other on a truncated ..
  56. ncbi Grey matter differences in bipolar disorder: a meta-analysis of voxel-based morphometry studies
    Sudhakar Selvaraj
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Bipolar Disord 14:135-45. 2012
    Several neuroimaging studies have reported structural brain differences in bipolar disorder using automated methods...
  57. pmc The Kraepelinian dichotomy - going, going... but still not gone
    Nick Craddock
    MRC Centre for Neuropsychiatric Genetics and Genomics, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Psychiatry 196:92-5. 2010
    ..These findings challenge the distinction between schizophrenia and bipolar disorder, and suggest that more attention should be given to the relationship between the functional psychoses and ..
  58. ncbi Distinguishing young people with emerging bipolar disorders from those with unipolar depression
    Elizabeth M Scott
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, 100 Mallet Street, Camperdown, NSW 2050, Australia
    J Affect Disord 144:208-15. 2013
    ..To facilitate early intervention, there is a need to distinguish unipolar versus bipolar illness trajectories in adolescents and young adults with adult-type mood disorders...
  59. pmc Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression
    Amit Anand
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
    Psychiatry Res 171:189-98. 2009
    ..study for the first time investigated resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder (BD) and compared them with findings in healthy controls and unipolar major depressive disorder (MDD) patient ..
  60. pmc Major depressive disorder with subthreshold bipolarity in the National Comorbidity Survey Replication
    Jules Angst
    Department of Psychiatry, Zurich University Psychiatric Hospital, Zurich, Switzerland
    Am J Psychiatry 167:1194-201. 2010
    ..The authors examined the prevalence and clinical correlates of major depressive disorder with subthreshold bipolarity compared with pure major depressive disorder in the National Comorbidity Survey Replication (NCS-R)...
  61. ncbi Anatomy of bipolar disorder and schizophrenia: a meta-analysis
    Ian Ellison-Wright
    Brain Mapping Unit, University of Cambridge, Cambridge, UK
    Schizophr Res 117:1-12. 2010
    ..results have indicated that the two major, classically distinct forms of psychosis - schizophrenia and bipolar disorder - may share causative factors in common...
  62. ncbi Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data
    Brian Hallahan
    Department of Psychiatry, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland
    Biol Psychiatry 69:326-35. 2011
    There is substantial inconsistency in results of brain structural magnetic resonance imaging studies in adult bipolar disorder. This is likely consequent upon limited statistical power of studies together with their clinical and ..
  63. ncbi The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: update 2012 on the long-term treatment of bipolar disorder
    Heinz Grunze
    Newcastle University, Institute of Neuroscience, Newcastle upon Tyne, UK
    World J Biol Psychiatry 14:154-219. 2013
    ..Their purpose is to supply a systematic overview of all scientific evidence pertaining to the long-term treatment of bipolar disorder in adults.
  64. ncbi Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder
    D Cotter
    Department of Psychological Medicine and Neuropathology, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 58:545-53. 2001
    ..In this investigation, we have simultaneously assessed glial cell density and neuronal density and size in the anterior cingulate cortex in schizophrenia, major depressive disorder, and bipolar disorder.
  65. pmc Increased peripheral blood expression of electron transport chain genes in bipolar depression
    Robert D Beech
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
    Bipolar Disord 12:813-24. 2010
    To identify specific genetic pathways showing altered expression in peripheral blood of depressed subjects with bipolar disorder (BPD).
  66. ncbi Cigarette smoking among persons with schizophrenia or bipolar disorder in routine clinical settings, 1999-2011
    Faith Dickerson
    Stanley Research Center, Sheppard Pratt Health System, 6501 North Charles St, Baltimore, MD 21204, USA
    Psychiatr Serv 64:44-50. 2013
    This study examined the prevalence of cigarette smoking and the quantity of cigarettes consumed by individuals with schizophrenia or bipolar disorder and by those with no psychiatric disorder in the period 1999-2011.
  67. pmc Impact of a microRNA MIR137 susceptibility variant on brain function in people at high genetic risk of schizophrenia or bipolar disorder
    Heather C Whalley
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Neuropsychopharmacology 37:2720-9. 2012
    ..risk allele) on brain activation during a sentence completion task that differentiates individuals with SCZ, bipolar disorder (BD), and their relatives from controls...
  68. ncbi Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium
    N L Johnston-Wilson
    Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, MD 21287 4933, USA
    Mol Psychiatry 5:142-9. 2000
    Severe psychiatric disorders such as schizophrenia, bipolar disorder and major depressive disorder are brain diseases of unknown origin...
  69. ncbi Is bipolar disorder an inflammatory condition? The relevance of microglial activation
    Laura Stertz
    Laboratory of Molecular Psychiatry, Centro de Pesquisas Experimentais, Hospital de Clinicas de Porto Alegre, and INCT for Translational Medicine, Brazil
    Curr Opin Psychiatry 26:19-26. 2013
    Literature published over the past few years indicates that bipolar disorder has an inflammatory component but does not explicitly define bipolar disorder as an inflammatory or a noninflammatory condition.
  70. ncbi Meta-analysis of neuropsychological functioning in euthymic bipolar disorder: an update and investigation of moderator variables
    Monica C Mann-Wrobel
    VA Capitol Network VISN 6 Mental Illness Research, Education, and Clinical Center MIRECC Durham, NC 27705, USA
    Bipolar Disord 13:334-42. 2011
    Cognitive impairment is frequently observed among individuals with bipolar disorder during acute and euthymic phases of the illness...
  71. ncbi Demographic and clinical characteristics of individuals in a bipolar disorder case registry
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 63:120-5. 2002
    The goal of this analysis was to characterize a cohort of 3000 persons who self-identified as having bipolar disorder by demographic, clinical, and treatment characteristics and to document the burden that this disorder imposed on their ..
  72. ncbi The stanley foundation brain collection and neuropathology consortium
    E F Torrey
    Stanley Foundation Research Programs, 5430 Grosvenor Lane, Suite 200, Bethesda, MD 20814, USA
    Schizophr Res 44:151-5. 2000
    ..attempt to supplement existing brain collections for the purpose of promoting research on schizophrenia and bipolar disorder. Specimens are collected with the permission of the families in a standardized manner, with half of each ..
  73. ncbi Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Bethesda, MD 20814, USA
    J Clin Psychiatry 71:864-72. 2010
    ..We examined the influence of age at onset of illness and the delay in time to first treatment on morbidity in adulthood...
  74. pmc The functional neuroanatomy of bipolar disorder: a consensus model
    Stephen M Strakowski
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 14:313-25. 2012
    ..in recent years, such that functional magnetic resonance imaging, in particular, is now widely used to study bipolar disorder. However, discrepant findings are common...
  75. ncbi Omega-3 for bipolar disorder: meta-analyses of use in mania and bipolar depression
    Jerome Sarris
    Department of Psychiatry, Faculty of Medicine, The University of Melbourne, Richmond, Victoria, Australia
    J Clin Psychiatry 73:81-6. 2012
    Studies using augmentation of pharmacotherapies with omega-3 in bipolar disorder have been conducted; however, to date a specific meta-analysis in this area has not been published...
  76. ncbi Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Hum Mol Genet 14:241-53. 2005
    Accumulating evidence suggests that mitochondrial dysfunction underlies the pathophysiology of bipolar disorder (BD) and schizophrenia (SZ)...
  77. ncbi Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder
    Bruno Etain
    Psychiatrie Génétique, INSERM U 955, Creteil 94000, France
    Hum Mol Genet 21:4030-7. 2012
    Patients affected by bipolar disorder (BD) frequently report abnormalities in sleep/wake cycles. In addition, they showed abnormal oscillating melatonin secretion, a key regulator of circadian rhythms and sleep patterns...
  78. ncbi Lithium: still a major option in the management of bipolar disorder
    Rasmus W Licht
    Mood Disorders Research Unit, Aarhus University Hospital, Risskov, Risskov, Denmark
    CNS Neurosci Ther 18:219-26. 2012
    Still after more than 50 years, lithium is a major treatment of bipolar disorder, even though it has not been promoted by the pharmaceutical industry over the last decades...
  79. ncbi The loudness dependence of the auditory evoked potential (LDAEP) in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controls
    Young Min Park
    Department of Psychiatry, Inje University, Ilsan Paik Hospital, 2240 Daehwa dong, Ilsanseo gu, Goyang 411 706, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 34:313-6. 2010
    Serotonergic dysfunction in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorder, and healthy controls was evaluated by measuring the activity of the loudness dependence of the auditory evoked potential (LDAEP).
  80. pmc Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD
    Heike Weber
    Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2076-85. 2011
    Recently, several genome-wide association studies (GWAS) on bipolar disorder (BPD) suggested novel risk genes. However, only few of them were followed up and further, the specificity of these genes is even more elusive...
  81. pmc The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)
    Agustin Ibanez
    Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology, Favaloro University, Buenos Aires, Argentina
    PLoS ONE 7:e37306. 2012
    Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making...
  82. ncbi The functional neuroanatomy of bipolar disorder
    Michael A Cerullo
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Int Rev Psychiatry 21:314-22. 2009
    ..manuscript, research articles using functional magnetic resonance imaging (fMRI) to study adult patients with bipolar disorder were reviewed...
  83. ncbi DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder
    W Hennah
    Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU, Scotland
    Mol Psychiatry 14:865-73. 2009
    Disrupted in schizophrenia 1 (DISC1) has been associated with risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism and Asperger syndrome, but apart from in the original translocation family, true ..
  84. pmc Mania-like behavior induced by disruption of CLOCK
    Kole Roybal
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 104:6406-11. 2007
    Circadian rhythms and the genes that make up the molecular clock have long been implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central transcriptional activator of molecular rhythms, CLOCK, may be ..
  85. ncbi Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder Questionnaire
    R M Hirschfeld
    Department of Psychiatry and Behavioral Sciences, Medical Branch, the University of Texas at Galveston 77555 01888, USA
    Am J Psychiatry 157:1873-5. 2000
    Bipolar spectrum disorders, which include bipolar I, bipolar II, and bipolar disorder not otherwise specified, frequently go unrecognized, undiagnosed, and untreated...
  86. ncbi A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes
    Roos C Padmos
    Department of Immunology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Arch Gen Psychiatry 65:395-407. 2008
    ..Mood disturbances are associated with an activated inflammatory response system...
  87. ncbi Is sex important? Gender differences in bipolar disorder
    Arianna Diflorio
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Heath Park, Cardiff, UK
    Int Rev Psychiatry 22:437-52. 2010
    ..In the case of bipolar disorder, however, it is widely perceived that the reported equal rate of illness in men and women reflects no ..
  88. ncbi Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder
    Dara M Cannon
    Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 62:870-7. 2007
    ....
  89. ncbi A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder
    Z Kaminsky
    The Krembil Family Epigenetics Laboratory, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Mol Psychiatry 17:728-40. 2012
    ..fine mapping DNA methylation differences at the human leukocyte antigen (HLA) complex group 9 gene (HCG9) in bipolar disorder (BPD)...
  90. ncbi Expression profiling in monozygotic twins discordant for bipolar disorder reveals dysregulation of the WNT signalling pathway
    N Matigian
    Queensland Centre for Mental Health Research, Herston, QLD, Australia
    Mol Psychiatry 12:815-25. 2007
    To identify genes dysregulated in bipolar disorder (BD1), we carried out global gene expression profiling using whole-genome microarrays...
  91. ncbi Brain metabolic alterations in medication-free patients with bipolar disorder
    Stephen R Dager
    Department of Radiology, University of Washington, Seattle 98105, USA
    Arch Gen Psychiatry 61:450-8. 2004
    b>Bipolar disorder (BD) has substantial morbidity and incompletely understood neurobiological underpinnings.
  92. ncbi Genome-wide association study of bipolar I disorder in the Han Chinese population
    M T M Lee
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Mol Psychiatry 16:548-56. 2011
    ..55 × 10(-5) and P=1.48 × 10(-5), respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder...
  93. ncbi The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives
    G Lelli-Chiesa
    Section of Neurobiology of Psychosis, Institute of Psychiatry, King s College London, UK
    Psychol Med 41:779-88. 2011
    ..is also thought to increase the risk of a number of disorders characterized by affective morbidity including bipolar disorder (BD), major depressive disorder (MDD) and anxiety disorders...
  94. pmc Altered microRNA expression profiles in postmortem brain samples from individuals with schizophrenia and bipolar disorder
    Michael P Moreau
    Department of Genetics, Rutgers University, Piscataway, New Jersey 08854 8095, USA
    Biol Psychiatry 69:188-93. 2011
    ..MicroRNAs (miRNAs) are potent regulators of gene expression with proposed roles in brain development and function. We hypothesized that miRNA expression profiles are altered in individuals with severe psychiatric disorders...
  95. ncbi A longitudinal study of premorbid IQ Score and risk of developing schizophrenia, bipolar disorder, severe depression, and other nonaffective psychoses
    Stanley Zammit
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales
    Arch Gen Psychiatry 61:354-60. 2004
    ..Preliminary evidence suggests there is no such effect for nonpsychotic bipolar disorder. To our knowledge, there are no prior population-based, longitudinal studies of premorbid IQ score and risk ..
  96. ncbi The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the treatment of acute bipolar depression
    Heinz Grunze
    Newcastle University, RVI, Division of Psychiatry, Institute of Neuroscience, Newcastle upon Tyne, UK
    World J Biol Psychiatry 11:81-109. 2010
    ..Their purpose is to supply a systematic overview of all scientific evidence pertaining to the treatment of acute bipolar depression in adults...
  97. ncbi Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation
    Allison G Harvey
    Sleep and Psychological Disorders Lab, Department of Psychology, University of California, 3210 Tolman Hall, 1650, Berkeley, CA 94720 1650, USA
    Am J Psychiatry 165:820-9. 2008
    Despite advances in the treatment of bipolar disorder, a significant proportion of patients experience disabling symptoms between episodes, and relapse rates are high...
  98. pmc Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    Jonathan Mill
    Krembil Family Epigenetic Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Am J Hum Genet 82:696-711. 2008
    Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia and bipolar disorder. To date, however, few studies have investigated the role of DNA methylation in major psychosis, and none have taken a genome-..
  99. ncbi High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides
    Emanuel Schwarz
    Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom
    J Proteome Res 7:4266-77. 2008
    ..lipid levels in the prefrontal cortex (Brodmann area 9) of 45 subjects including 15 schizophrenia and 15 bipolar disorder patients as well as 15 controls samples...
  100. ncbi The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatients
    Jules Angst
    Zurich University Psychiatric Hospital, Lenggstrasse 31, P O Box 1931, 8032 Zurich, Switzerland
    J Affect Disord 88:217-33. 2005
    ..As such, an instrument for self-assessment of hypomanic symptoms might increase the detection of suspected and of manifest, but under-treated, cases of bipolar disorders...

Research Grants81

  1. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Dieter A Wolf; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): ): Bipolar disorder (BPD) is a neuropsychiatric condition defined by a lifetime of relapsing &remitting manic &depressive episodes...
  2. Complex I: Role of L Subunit in Proton Translocation
    Steven B Vik; Fiscal Year: 2011
    ..are risk factors for a wide range of diseases and disorders, such as multiple sclerosis, Type 2 diabetes, and bipolar disorder. Some such alleles are known to be causative for fatal disorders such as Leber's hereditary optic ..
  3. Cell stress, development, and stimulant-induced behavior: Regulation by GSK3
    Marjelo A Mines; Fiscal Year: 2012
    ..is a feasible therapeutic target because the GSK3 inhibitor lithium is already widely used as a treatment for bipolar disorder and many new small molecule selective GSK3 inhibitors are under development...
  4. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..Psychiatric Disorders such as alcohol and other substance abuse disorders, unipolar depression, bipolar disorder and attention-deficit/hyperactivity disorder (ADHD) are amongst the most significant causes of morbidity and ..
  5. Role of Matrix Metalloproteinase-1 in Endothelial Cell Senescence
    Catherine D Mao; Fiscal Year: 2010
    ..Lithium is commonly used to treat bipolar disorder as well as to activate the oncogenic 2-catenin signaling pathway via inhibition of glycogen synthase kinase (..
  6. Reversing Corticosteroid-Induced Memory Impairment
    E Sherwood Brown; Fiscal Year: 2013
    ..implications to patients with mood disorders, as a subset of people with major depressive disorder and bipolar disorder have elevated cortisol levels...
  7. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    ..Dysregulated aggression is a component of mental disorders including bipolar disorder, schizophrenia, and borderline personality disorder...
  8. Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human Neurons
    JEN PAN; Fiscal Year: 2013
    ..provided by applicant): This is a new R21 application to study in live human neurons the function of a bipolar disorder susceptibility gene encoding a neuronal calcium channel...
  9. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2012
    ..J., and Rawson,N.E. (2005). Aberrant intracellular calcium signaling in olfactory neurons from patients with bipolar disorder. Am. J. Psychiatry 162, 616-618. Rawson,N.E. (2000). Human olfaction...
  10. Postpartum Depression: Role of Sleep &Genetic Risk in Postpartum Mood Disorders
    Katherine M Sharkey; Fiscal Year: 2013
    ..study of mood, sleep, and genetic risk in perinatal women with a history of major depressive disorder or bipolar disorder. Sleep and mood are assessed in 125 women at 3rd trimester of pregnancy, and 2, 6, and 16 weeks postpartum...
  11. Presynaptic Mechanisms Regulating the Dopamine Transporter
    JAMES A HARDAWAY; Fiscal Year: 2013
    ..brain are associated with numerous neuropsychiatric and neurodegenerative disorders including schizophrenia, bipolar disorder, attention-deficit hyperactivity disorder and Parkinson's disease...
  12. Cannabinoid regulation of glycogen synthase kinase-3
    Cecilia J Hillard; Fiscal Year: 2013
    ..In addition, people with bipolar disorder have a 20-40% lifetime prevalence of cannabis use, compared to 6% in the general population...
  13. CHOLINERGIC MECHANISMS OF REM SLEEP GENERATION
    Helen A Baghdoyan; Fiscal Year: 2013
    ..needed for attentional, learning, and memory functions of normal wakefulness, and schizophrenia and bipolar disorder are characterized by alterations in cortical activity and by sleep disruption...
  14. Mediators of Lithium Action in Olfactory Epithelium
    Evaristus A Nwulia; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bipolar Disorder (BD) is a chronic debilitating illness with substantial societal burden...
  15. Identifying Biomarkers for Post-Partum Depression in African-American Women
    Patrick F Sullivan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In contrast to progress for autism, bipolar disorder, and schizophrenia, discerning the biological basis of major depressive disorder (MDD) has been difficult...
  16. Genetic and Optogenetic Models to Dissect the Role of the Serotonin 1B Receptor
    Katherine M Nautiyal; Fiscal Year: 2013
    ..circuits underlying aggression and impulsivity will have implications for the treatments of several neuropsychiatric disorders, including addiction, attention-deficit hyperactivity disorde and bipolar disorder, and suicidal depression.
  17. Web-Based Program to Improve Antidepressant Medication Adherence
    Rebekah K Hersch; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Mood disorders, including major depressive disorder, dysthymia, and bipolar disorder, affect nearly 21 million Americans or 9.5% of the U.S. population age 18 years of age and older...
  18. Using a Biomarker Panel for Detecting Adolescent Depression
    John A Bilello; Fiscal Year: 2010
    ..In addition it is estimated that 15 percent of teens with depression eventually develop bipolar disorder and 30 percent of teens with depression also develop a substance abuse problem...
  19. Disruption of Extracellular Matrix-Glial Interactions in Schizophrenia
    Sabina Berretta; Fiscal Year: 2013
    ..abnormalities affecting CSPGs in the amygdala and entorhinal cortex of subjects with schizophrenia, but not bipolar disorder. Marked increases of glial cells expressing CSPGs were not accompanied by astrocytosis, suggesting ..
  20. Effect of Major Depression and antidepressants on human neurogenesis
    Maura Boldrini; Fiscal Year: 2013
    ..We will also match the MD groups on proportions with comorbid diagnoses and the percentage that have MDD or bipolar disorder. All cases, including controls, will have psychological autopsies determining DSM Axis I and Axis II ..
  21. Aptamer probes for Epigenetic Peptide Targets
    MARK PATRICK MCPIKE; Fiscal Year: 2010
    ..For example, mental health diseases such as bipolar disorder and schizophrenia are associated with epigenetic changes in the promoters of enzymes that metabolize ..
  22. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen A McClung; Fiscal Year: 2013
    ..who have genetic disruptions in circadian gene function are more prone to developing mood disorders such as bipolar disorder or seasonal affective disorder and these disorders are highly co-morbid with addiction...
  23. Nicotinic receptor stimulation and epigenetic regulation of GABAergic function.
    Alessandro Guidotti; Fiscal Year: 2013
    ..on the epigenetic regulation of GABAergic neurons to better understand the pathogenesis and pharmacological treatment of sensory/cognitive components of SZ, bipolar disorder and other diseases with psychiatric or cholinergic components.
  24. Novel Therapeutics in PTSD: A Randomized Clinical Trial of Mifepristone
    Gerardo Villarreal; Fiscal Year: 2013
    ..effects on mood, cognition and sleep disturbance in some neuropsychiatric conditions (major depression, bipolar disorder, primary insomnia)...
  25. Melanocortin Signaling in Depression
    Michael Lutter; Fiscal Year: 2013
    ..type II diabetes mellitus and heart disease are all much more common in patients with major depression, bipolar disorder, and post-traumatic stress disorder...
  26. A Conserved G-rich Region within Human TH Promoter Regulates Its Activity
    Soumitra Basu; Fiscal Year: 2011
    ..gene expression is important because aberrant TH expression is linked to many psychiatric problems including bipolar disorder, manic depression, and schizophrenia...
  27. GENE EXPRESSION EXON ARRAY BIOMARKERS TO DIAGNOSE SCHIZOPHRENIA
    Terry W Osborn; Fiscal Year: 2010
    ..innovative, commercially-viable means of genetically diagnosing and differentiating schizophrenia (SZ), bipolar disorder (BD) and Major Depressive Disorder (MDD) from normal/healthy individuals (NC) with mRNA gene expression ..
  28. Monoallelic expression in neurons derived from induced pluripotent stem cells
    Herbert M Lachman; Fiscal Year: 2013
    ..have also been found in a subset of families with schizophrenia (SZ), autism spectrum disorders (ASD) and bipolar disorder (BD)...
  29. NEURONAL CONTROL OF INTERACTIONS AMONG BEHAVIORS
    William B Kristan; Fiscal Year: 2013
    ..The comparative approach has a long and fruitful history: questions answered in simple animals provide information and inspiration for asking the same questions in more complex animals, like rats, monkeys, and eventually humans. ..
  30. From Defective Microglia to Cortical Activity and Pathological Behavior
    Mario R Capecchi; Fiscal Year: 2013
    ..linked to many neuropsychiatric disorders including obsessive compulsive disorder (OCD), major depression, bipolar disorder, autism, schizophrenia and Alzheimer disease...
  31. Neuromorphometry of Psychosis in Bipolar Disorder
    Daniel Mamah; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although current nosology defines schizophrenia (SCZ) and bipolar disorder as unique constructs with distinctive clinical characteristics, there exist significant symptomatic and familial overlap...
  32. Neuroimaging mechanisms of overlap between alcoholism and bipolar disorder
    JAMES JOSEPH PRISCIANDARO; Fiscal Year: 2013
    ..Research: Bipolar disorder (BD) is the Axis I psychiatric condition most strongly associated with substance use disorders (SUD);co-..
  33. High-throughput behavior-based dopaminergic drug discovery in the zebrafish
    David Kokel; Fiscal Year: 2013
    ..Eventually, I hope that this work will lead to novel therapeutic approaches for treating mental illness and other neurological disorders. ..
  34. Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Con
    Hilary P Blumberg; Fiscal Year: 2010
    ..entitled: Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Contribute to High Risk in Bipolar Disorder. The proposed study addresses a critical gap in knowledge that could have a major impact on progress in ..
  35. Pharmacoepidemiology of Atypical Antipsychotic Drugs
    William V Bobo; Fiscal Year: 2013
    ..long-term goal is a career in academic psychiatry focused on research that improves the care of patients with bipolar disorder. My plan is to conduct epidemiologic studies that clarify the relative safety and effectiveness of ..
  36. Mechanisms of Valproic Acid-Induced Neurodevelopmental and Behavioral Defects
    Elizabeth M Powell; Fiscal Year: 2013
    ..to avoid adverse neurodevelopmental effects in pregnant women who require VPA for control of epilepsy and bipolar disorder. In addition, the project seeks to establish a paradig that would enable systematic investigation of the ..
  37. Chemical Genomic Approaches to Neurobiology of DISC1
    Li Huei Tsai; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Schizophrenia and bipolar disorder are chronic debilitating disorders that affect 1-3% of the population. The etiology of these disorders is completely unknown...
  38. Gonadal Hormones and Depression:The Role of Mood Disorder Risk Gene CACNA1C
    Todd D Gould; Fiscal Year: 2012
    ..2 L-type calcium channel, and a diagnosis of bipolar disorder or depression...
  39. Behavioral Approach System Dysregulation in Adolescents with Bipolar Disorder
    Snezana Urosevic; Fiscal Year: 2013
    ..in research on adolescents with bipolar disorders, thus expanding her current research background with adult bipolar disorder populations;2) to gain expertise in functional magnetic resonance imaging (fMRI), expanding the repertoire of ..
  40. The role of Type 3 deiodinase in Brain Sexual Differentiation
    Arturo Hernandez; Fiscal Year: 2010
    ..light into the etiology and pathophysiology of certain neurological conditions in humans that exhibit a gender bias and that are characterized by abnormal behavior, such as autism, schizophrenia, bipolar disorder, depression and others.
  41. The Role Leptin on Arousal
    PAIGE B BECK; Fiscal Year: 2013
    ..such as that observed in a number of neuropsychiatric disorders such as schizophrenia, anxiety disorder, bipolar disorder, and narcolepsy...
  42. Calcium Sensing Proteins in Depression
    Yogesh Dwivedi; Fiscal Year: 2013
    ..e., bipolar disorder (BPD) or schizophrenia (SCHIZ)...
  43. Extracellular anomalies in Schizophrenia: from molecules to symptoms
    Sabina Berretta; Fiscal Year: 2013
    ..affecting the extracellular matrix (ECM) in medial temporal regions of subjects with schizophrenia, but not bipolar disorder. Our data points to anomalous expression of chondroitin sulfate proteoglycans (CSPGs), a main component of ..
  44. The Impact of Deep Brain Stimulation on Frontal-Subcortical Emotional Processing
    Joseph S Neimat; Fiscal Year: 2012
    ....
  45. Epigenetic Markers For Development of Schizophrenia
    Alessandro Guidotti; Fiscal Year: 2013
    ..DNA methylation/demethylation process is perturbed in neuropsychiatric disorders such as schizophrenia (SZ), bipolar disorder (BP), and autism...
  46. Structural and Functional Studies of the Sac Family Phosphoinositide Phosphatases
    Yuxin Mao; Fiscal Year: 2013
    ..linked to a number of human hereditary diseases, including certain cancers, diabetes, Lowe's syndrome, Bipolar disorder, Charcot-Marie-Tooth disease (CMT) and Amyotrophic Lateral Sclerosis (ALS)...
  47. Molecular analysis of bipolar and schizophrenia candidate genes
    Herbert M Lachman; Fiscal Year: 2012
    ..Although there have been major advances in understanding the genetic basis of schizophrenia (SZ) and bipolar disorder (BD) using genome-wide association studies (GWAS), identifying disease causing functional variants in ..
  48. Neuroimaging and Behavioral Biomarkers for ADHD in Children
    Martin H Teicher; Fiscal Year: 2010
    ..Pediatric bipolar disorder is an even more controversial diagnosis, associated with widespread disparity between experts in criteria and ..
  49. Sp4 Pathway in the Modulation of Sensorimotor Gating and Memory
    XIANJIN ZHOU; Fiscal Year: 2013
    ..The Sp4 gene is significantly associated with schizophrenia and bipolar disorder. In mouse studies, reduced expression of the Sp4 gene impaired long-term potentiation (LTP) in hippocampal ..
  50. Summit on Drug Discovery in Tuberous Sclerosis Complex and Related Disorders
    Elizabeth P Henske; Fiscal Year: 2011
    ..than 50% have moderate to severe intellectual disabilities and mental health issues including depression, bipolar disorder, anxiety disorder and autism spectrum disorder...
  51. Circadian Clock Genes in Bipolar Disorder
    MICHAEL JOSEPH MCCARTHY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bipolar disorder (BD) is a life-threatening mental illness that affects 1-2% of the population, including ~100,000 veterans...
  52. A Molecular Method to Selectively Record Activation of Dopamine Receptor Subtypes
    Gilad Barnea; Fiscal Year: 2012
    ..Imbalances in the dopamine system have been implicated in disorders as diverse as schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, Tourette's syndrome, addiction, Parkinson's disease, and ..
  53. DNA METHYLOME ANALYSIS IN BIPOLAR DISORDER
    ART PETRONIS; Fiscal Year: 2013
    ..provided by applicant): Epigenetic misregulation is consistent with various non-Mendelian features of bipolar disorder (BPD), such as the discordance of identical twins, significant fluctuations in disease course, sex- and ..
  54. A Novel Strategy for Combating Obesity: Reprogramming Neural Circuits
    KAY MAXINE TYE; Fiscal Year: 2013
    ..that could also be applied to other neuropsychiatric disorders including addiction, anxiety, depression, bipolar disorder and obsessive compulsive disorder (OCD)...
  55. Epigenetic Influence on Thyroid Hormone Action in the Brain and on Behavior
    Arturo Hernandez; Fiscal Year: 2013
    ..factors may influence their onset, familial studies have shown that schizophrenia, autism, depression, bipolar disorder, and others, all have a variable but strong genetic component...
  56. The Role of cAMP/PKA Signaling in Neural Circuits Underlying Memory Formation
    Seth M Tomchik; Fiscal Year: 2012
    ..maintaining ongoing projects on topics ranging from Drosophila learning and memory to the genetics of bipolar disorder in humans. Dr...
  57. The Role of cAMP/PKA Signaling in Neural Circuits Underlying Memory Formation
    Seth M Tomchik; Fiscal Year: 2013
    ..maintaining ongoing projects on topics ranging from Drosophila learning and memory to the genetics of bipolar disorder in humans. Dr...
  58. Epigenetic Mechanisms of Memory Storage
    EDWIN G ABEL; Fiscal Year: 2013
    ..and alterations in DNA methylation have been found in post-mortem brains from patients with schizophrenia and bipolar disorder. Defects in epigenetic modifications may contribute to impairments in synaptic plasticity and cognitive ..
  59. Attenuation of Corticosteroid-Induced Hippocampal Changes
    E Sherwood Brown; Fiscal Year: 2013
    ..implications for patients with mood disorders, as a subset of people with major depressive disorder and bipolar disorder show evidence of HPA axis activation and elevated cortisol...
  60. Novel Mechanisms Underlying Depression: PET Imaging of the Kappa Opioid Receptor
    Jeffrey M Miller; Fiscal Year: 2012
    ..dysphoria in normal controls, and have therapeutically mood-lowering (anti-manic) properties in one study in bipolar disorder. KOR stimulation may exert effects on mood through modulating dopamine release in the nucleus accumbens, a ..
  61. Cellular Circadian Clocks in Mood Disorders
    David K Welsh; Fiscal Year: 2013
    ..We will use similar methods to assess circadian function in neurons from Clock-d19 mutant mice, a model of bipolar disorder, and mice in which we have induced "learned helplessness", a model of depression...
  62. The Effect of Bipolar Disorder and its Comorbidities on Cognition in Older Adults
    ARIEL GERARD GILDENGERS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Bipolar disorder (BD) is the sixth leading cause of disability among all medical disorders in developed countries...
  63. Social Cognition and Functioning in Bipolar Disorder
    Michael F Green; Fiscal Year: 2010
    ..It is increasingly clear that recent advances in the treatment of the clinical symptoms of bipolar disorder (BPD) have not improved its functional outcome, which remains disappointing...
  64. Brain Mechanisms in Pediatric Bipolar Disorder and Attention Deficit Hyperactivit
    Mani N Pavuluri; Fiscal Year: 2010
    ..to RFA-04-MH-102, is to differentiate the alterations in cognitive and affective circuitry in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD) relative to typically developing operations...
  65. Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar Disorder
    David Miklowitz; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Bipolar disorder (BD) in youth is associated with significant impairments in functioning, treatment-resistance, and high public health costs...
  66. Sleep Activity Patterns and Temperature in Childhood Onset Bipolar Disorder
    Patricia Murphy; Fiscal Year: 2009
    Sleep and circadian rhythm disturbances are common features of bipolar disorder. Childhood onset bipolar disorder (COBD), in particular, is characterized by symptoms suggestive of altered regulation of sleep and wakefulness...
  67. OMEGA-3 FATTY ACIDS IN BIPOLAR DISORDER PROPHYLAXIS
    ANDREW STOLL; Fiscal Year: 2002
    ..trial is to assess the efficacy of omega-3 fatty acids (03FA) in preventing recurrence in patients with bipolar disorder, type 1...
  68. Naltrexone for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2006
    ..b>Bipolar disorder is a severe and persistent psychiatric illness affecting 1.2-1...
  69. Comparative Effectiveness Study for Bipolar Disorder
    Andrew A Nierenberg; Fiscal Year: 2010
    ..In fact, QTP has become the most commonly prescribed medication for bipolar disorder. This is true in spite of the observation that treatment with SGAs is associated with significant metabolic ..
  70. 31P magnetization transfer study of bipolar disorder
    Chun S Zuo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Magnetization Transfer Study of Bipolar Disorder Abstract The disease mechanism of bipolar disorder remains largely unknown...
  71. VALPROATE VERSUS LITHIUM IN BIPOLAR RAPID CYCLING
    Joseph Calabrese; Fiscal Year: 1999
    Although lithium remains the treatment of choice for bipolar disorder, only 6O-80% of classic bipolar patients have a satisfactory clinical response...
  72. Glucogen Synthase Kinase 3beta and Bipolar Disorder
    Xiaohua Li; Fiscal Year: 2007
    ..regulation of glycogen synthase kinase 3beta, its modulation by mood stabilizers and its potential role in bipolar disorder. The five-year plans to enable the candidate to develop into an independent psychiatric investigator to ..
  73. Neurophysiology of Working Memory in Bipolar Disorder
    Caleb Adler; Fiscal Year: 2007
    ..Caleb M. Adler's developing expertise in neuroimaging and bipolar disorder. Bipolar disorder is a common psychiatric illness accompanied by severe morbidity and mortality...
  74. Genetic Linkage Studies in Bipolar Disorder Families
    Elliot Gershon; Fiscal Year: 2009
    ..Johns Hopkins, the University of Chicago, and the National Institute of Mental Health--that has developed a bipolar disorder family resource that has proven to be uniquely valuable in testing clinically based hypotheses about the ..
  75. MRI/MRSI Studies of Bipolar Treatment Response
    Perry Renshaw; Fiscal Year: 2009
    ..dysfunction (increased gray matter lactate and glutamate/glutamine/GABA (Glx)) in untreated patients with bipolar disorder;(2) measured changes toward normal values in brain Glx were associated with lithium treatment, but not ..
  76. ACUTE MANIA--HALOPERIDOL DOSE AND LORAZEPAM AUGMENTATION
    James Chou; Fiscal Year: 1993
    ..6) Li increases HAL side effects. As a secondary hypothesis, if HAL 25mg/d produces greater clinical improvement than HAL 5mg/d then, 7) Any advantage of HAL 25mg/d (alone) over HAL 5mg/d (alone) is made up by LZP augmentation...
  77. RESEARCH TRAINING IN JUVENILE BIPOLAR DISORDER
    Pablo Davanzo; Fiscal Year: 2002
    ..a program of career development and research in psychopharmacology and neuroimaging of juveniles with bipolar disorder. A focus of this program will be a clinical trial with a mood-stabilizer (divalproex sodium) in a group of ..
  78. MRSI of Frontosubcortical Circuits in Bipolar Disorder
    RAYMOND DEICKEN; Fiscal Year: 2004
    DESCRIPTION: (provided by applicant) Developing evidence strongly suggests that bipolar disorder involves localized abnormalities in specific brain structures that participate in fronto-limbic-subcortical circuits regulating mood...
  79. Early Detection of Risk Factors for Bipolar Mania
    Barbara Cornblatt; Fiscal Year: 2009
    ..e., pre-manic) phase of adult onset bipolar disorder. Pilot work is considered essential for demonstrating the viability of the prodromal concept in bipolar ..
  80. Psychiatric Illness: Multigene Expression Classification
    JAMES CLELLAND; Fiscal Year: 2005
    ..proposal is designed to produce data for the development of a biological classification of schizophrenia and bipolar disorder, based on high density microarray measurements of transcribed white blood cell (leukocyte) mRNA...
  81. Single nucleotide polymorphisms of neuronal CACNA1C L-type calcium channels assoc
    Diane Lipscombe; Fiscal Year: 2011
    ..is a new R21 application to study the role of a neuronal calcium channel in determining susceptibility to bipolar disorder. All excitable cells use calcium ion channels on their surface to read electrical signals and convert them ..