seasonal affective disorder

Summary

Summary: A syndrome characterized by depressions that recur annually at the same time each year, usually during the winter months. Other symptoms include anxiety, irritability, decreased energy, increased appetite (carbohydrate cravings), increased duration of sleep, and weight gain. SAD (seasonal affective disorder) can be treated by daily exposure to bright artificial lights (PHOTOTHERAPY), during the season of recurrence.

Top Publications

  1. ncbi The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence
    Robert N Golden
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 162:656-62. 2005
  2. pmc The phase shift hypothesis for the circadian component of winter depression
    Alfred J Lewy
    Oregon Health and Science University, Department of Psychiatry, Sleep and Mood Disorders Laboratory, Portland, Oregon, USA
    Dialogues Clin Neurosci 9:291-300. 2007
  3. doi Bright-light therapy in the treatment of mood disorders
    Gerald Pail
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Neuropsychobiology 64:152-62. 2011
  4. doi Potential animal models of seasonal affective disorder
    Joanna L Workman
    Department of Psychology, The Ohio State University, Columbus, OH 43201, USA
    Neurosci Biobehav Rev 35:669-79. 2011
  5. ncbi Controlled trial of naturalistic dawn simulation and negative air ionization for seasonal affective disorder
    Michael Terman
    Department of Biopsychology, New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Psychiatry 163:2126-33. 2006
  6. ncbi Circadian time of morning light administration and therapeutic response in winter depression
    J S Terman
    New York State Psychiatric Institute, 1051 Riverside Dr, Unit 50, New York, NY 10032, USA
    Arch Gen Psychiatry 58:69-75. 2001
  7. pmc Delayed sleep phase syndrome is related to seasonal affective disorder
    Heon Jeong Lee
    Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea
    J Affect Disord 133:573-9. 2011
  8. doi A randomized, placebo-controlled trial of bright light and high-density negative air ions for treatment of Seasonal Affective Disorder
    Randall Flory
    Department of Psychology, Hollins University, Roanoke, VA 24020, USA
    Psychiatry Res 177:101-8. 2010
  9. pmc A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder
    Kathryn A Roecklein
    Graduate Program in Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
    J Affect Disord 114:279-85. 2009
  10. ncbi Autobiographical memory style in seasonal affective disorder and its relationship to future symptom remission
    T Dalgeish
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, England
    J Abnorm Psychol 110:335-40. 2001

Detail Information

Publications257 found, 100 shown here

  1. ncbi The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence
    Robert N Golden
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 162:656-62. 2005
    ..The purpose of this study was to assess the evidence base for the efficacy of light therapy in treating mood disorders...
  2. pmc The phase shift hypothesis for the circadian component of winter depression
    Alfred J Lewy
    Oregon Health and Science University, Department of Psychiatry, Sleep and Mood Disorders Laboratory, Portland, Oregon, USA
    Dialogues Clin Neurosci 9:291-300. 2007
    ..The leading hypothesis for winter depression (seasonal affective disorder, or SAD) is the phase shift hypothesis (PSH)...
  3. doi Bright-light therapy in the treatment of mood disorders
    Gerald Pail
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Neuropsychobiology 64:152-62. 2011
    Bright-light therapy (BLT) is established as the treatment of choice for seasonal affective disorder/winter type (SAD)...
  4. doi Potential animal models of seasonal affective disorder
    Joanna L Workman
    Department of Psychology, The Ohio State University, Columbus, OH 43201, USA
    Neurosci Biobehav Rev 35:669-79. 2011
    b>Seasonal affective disorder (SAD) is characterized by depressive episodes during winter that are alleviated during summer and by morning bright light treatment. Currently, there is no animal model of SAD...
  5. ncbi Controlled trial of naturalistic dawn simulation and negative air ionization for seasonal affective disorder
    Michael Terman
    Department of Biopsychology, New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Psychiatry 163:2126-33. 2006
    ..This trial assessed two novel nonpharmaceutical treatments for winter depression-naturalistic dawn simulation and high-density negative air ionization-delivered during the final hours of sleep...
  6. ncbi Circadian time of morning light administration and therapeutic response in winter depression
    J S Terman
    New York State Psychiatric Institute, 1051 Riverside Dr, Unit 50, New York, NY 10032, USA
    Arch Gen Psychiatry 58:69-75. 2001
    ..METHODS: Plasma melatonin was sampled in 42 patients with seasonal affective disorder, in the evening or overnight while depressed and after 10 to 14 days of light therapy (10 000 lux for ..
  7. pmc Delayed sleep phase syndrome is related to seasonal affective disorder
    Heon Jeong Lee
    Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea
    J Affect Disord 133:573-9. 2011
    Both delayed sleep phase syndrome (DSPS) and seasonal affective disorder (SAD) may manifest similar delayed circadian phase problems. However, the relationships and co-morbidity between the two conditions have not been fully studied...
  8. doi A randomized, placebo-controlled trial of bright light and high-density negative air ions for treatment of Seasonal Affective Disorder
    Randall Flory
    Department of Psychology, Hollins University, Roanoke, VA 24020, USA
    Psychiatry Res 177:101-8. 2010
    ..ions, and the efficacy of two placebo treatments, dim red light and low-density negative ions, for Seasonal Affective Disorder (SAD)...
  9. pmc A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder
    Kathryn A Roecklein
    Graduate Program in Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
    J Affect Disord 114:279-85. 2009
    ..a non-visual photopigment, may play a role in aberrant responses to low winter light levels in Seasonal Affective Disorder (SAD)...
  10. ncbi Autobiographical memory style in seasonal affective disorder and its relationship to future symptom remission
    T Dalgeish
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, England
    J Abnorm Psychol 110:335-40. 2001
    Autobiographical memory was examined in participants with seasonal affective disorder (SAD). In Experiment 1, participants with SAD performed an autobiographical memory task (AMT) in the winter, when depressed...
  11. ncbi Winter seasonal affective disorder: a follow-up study of the first 59 patients of the National Institute of Mental Health Seasonal Studies Program
    P J Schwartz
    Clinical Psychobiology Branch, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 153:1028-36. 1996
    The purpose of this study was to characterize the long-term course of patients with seasonal affective disorder.
  12. ncbi A controlled trial of timed bright light and negative air ionization for treatment of winter depression
    M Terman
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York 10032, USA
    Arch Gen Psychiatry 55:875-82. 1998
    Artificial bright light presents a promising nonpharmacological treatment for seasonal affective disorder. Past studies, however, have lacked adequate placebo controls or sufficient power to detect group differences...
  13. ncbi The Can-SAD study: a randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder
    Raymond W Lam
    Mood Disorders Centre, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1
    Am J Psychiatry 163:805-12. 2006
    Light therapy and antidepressants have shown comparable efficacy in separate studies of seasonal affective disorder treatment, but few studies have directly compared the two treatments...
  14. doi Winter depression recurrence one year after cognitive-behavioral therapy, light therapy, or combination treatment
    Kelly J Rohan
    Department of Psychology, University of Vermont, John Dewey Hall, 2 Colchester Avenue, Burlington, VT 05405 0134, USA
    Behav Ther 40:225-38. 2009
    The central public health challenge in the management of seasonal affective disorder (SAD) is prevention of depression recurrence each fall/winter season...
  15. ncbi Bright light treatment of winter depression: a placebo-controlled trial
    C I Eastman
    Department of Psychology, Rush Presbyterian St Luke s Medical Center, Chicago, Ill 60612, USA
    Arch Gen Psychiatry 55:883-9. 1998
    Bright light therapy is the recommended treatment for winter seasonal affective disorder (SAD)...
  16. doi Effect of seasonal affective disorder and pathological tanning motives on efficacy of an appearance-focused intervention to prevent skin cancer
    Joel Hillhouse
    Department of Community Health, East Tennessee State University, Campus Box 70674, Johnson City, TN 37614, USA
    Arch Dermatol 146:485-91. 2010
    To evaluate the robustness of an appearance-focused intervention to prevent skin cancer in individuals reporting seasonal affective disorder (SAD) symptoms and pathological tanning motives.
  17. ncbi [More than every tenth person have symptoms of seasonal affective disorder]
    Helle Østergaard Madsen
    Psykiatrisk Center København, afdeling O, Rigshospitalet, Edel Sauntés Alle 10, 2100 København Ø, Denmark
    Ugeskr Laeger 173:3013-6. 2011
    b>Seasonal affective disorder is a syndrome of classical depressive symptoms such as reduced energy, initiative and mood combined with atypical symptoms of increased appetite, weight and sleep duration...
  18. ncbi Seasonal affective disorder and latitude of living
    Greta Brancaleoni
    Department of Clinical Psychiatry, Institute of Clinical Medicine, Faculty of Medicine, University of Tromsø, and Psychiatric Department, University Hospital North, Norway
    Epidemiol Psichiatr Soc 18:336-43. 2009
    Since the importance of latitude of living for the prevalence of Seasonal Affective Disorder (SAD) is unclear, the study aims to test the latitude hypothesis by comparing SAD in two rather similar groups of students living at latitudes ..
  19. ncbi Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL
    Jack G Modell
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Biol Psychiatry 58:658-67. 2005
    b>Seasonal affective disorder (SAD) can cause significant distress and impairment. No antidepressant studies have previously attempted to prevent the onset of autumn-winter depression.
  20. ncbi Treatment compliance in light therapy: Do patients do as they say they do?
    Erin E Michalak
    J Affect Disord 68:341-2. 2002
  21. ncbi Use of health care services in seasonal affective disorder
    John M Eagles
    Royal Cornhill Hospital, Cornhill Road, Aberdeen AB25 2ZH, Scotland, UK
    Br J Psychiatry 180:449-54. 2002
    Little is known about the presentation and management of seasonal affective disorder (SAD) in primary care.
  22. ncbi Monorhinal odor identification and depression scores in patients with seasonal affective disorder
    T T Postolache
    Section on Biological Rhythms NIMH, Bethesda, MD 20892 1390, USA
    J Affect Disord 56:27-35. 1999
    ..that olfactory deficits may unmask seasonal rhythms in certain individuals, namely those with seasonal affective disorder (SAD)...
  23. ncbi Depressive symptomatology differentiates subgroups of patients with seasonal affective disorder
    Namni Goel
    Columbia University, New York, New York, USA
    Depress Anxiety 15:34-41. 2002
    Patients with seasonal affective disorder (SAD) may vary in symptoms of their depressed winter mood state, as we showed previously for nondepressed (manic, hypomanic, hyperthymic, euthymic) springtime states [Goel et al., 1999]...
  24. ncbi Changes of clinical pattern in seasonal affective disorder (SAD) over time in a German-speaking sample
    D Winkler
    Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 252:54-62. 2002
    The goals of this study are to provide estimates of clinical and demographic variables of patients with seasonal affective disorder (SAD) in Germany and Austria, to compare our results with those of previously published SAD studies, and ..
  25. doi Negative ion treatment increases positive emotional processing in seasonal affective disorder
    C J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychol Med 42:1605-12. 2012
    ..High-density negative ion (HDNI) treatment is an environmental manipulation that has efficacy in randomized clinical trials in seasonal affective disorder (SAD).
  26. doi Atypical pattern of rod electroretinogram modulation by recent light history: a possible biomarker of seasonal affective disorder
    Anne Marie Gagné
    Research Center University Laval Robert Giffard, Quebec, QC, Canada
    Psychiatry Res 187:370-4. 2011
    ..Retinal response modulation may represent an interesting biomarker of the disease for future research...
  27. ncbi Effects of tryptophan depletion on drug-free patients with seasonal affective disorder during a stable response to bright light therapy
    A Neumeister
    Department of General Psychiatry, Vienna University, Austria
    Arch Gen Psychiatry 54:133-8. 1997
    A dysfunction of the serotonin system may play a major role in the pathogenesis of seasonal affective disorder. Bright light therapy has been shown to be effective in the treatment of winter depression in patients with seasonal affective ..
  28. pmc Orexinergic signaling mediates light-induced neuronal activation in the dorsal raphe nucleus
    W Adidharma
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Neuroscience 220:201-7. 2012
    b>Seasonal affective disorder (SAD), a major depressive disorder recurring in the fall and winter, is caused by the reduction of light in the environment, and its depressive symptoms can be alleviated by bright light therapy...
  29. ncbi Cognitive-behavioral therapy, light therapy, and their combination in treating seasonal affective disorder
    Kelly J Rohan
    Uniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    J Affect Disord 80:273-83. 2004
    The need to develop supplementary or alternative treatments for seasonal affective disorder (SAD) is underscored by the significant minority (47%) of SAD patients that is refractory to light therapy, the persistence of residual symptoms ..
  30. ncbi Comparison of consultation rates in primary care attenders with and without seasonal affective disorder
    J E Andrew
    Health Services Research Unit, Aberdeen University, Aberdeen AB25 2ZD, UK
    J Affect Disord 62:199-205. 2001
    BACKGROUND: There is a lack of published information about the consultation patterns of patients with seasonal affective disorder (SAD) in primary care, when compared with non-seasonal controls (NSCs)...
  31. ncbi Long-term and preventative treatment for seasonal affective disorder
    Asa Westrin
    Department of Clinical Sciences, Division of Psychiatry, Lund University Hospital, Lund, Sweden
    CNS Drugs 21:901-9. 2007
    Recurrent major depressive disorder with regular seasonal patterns, commonly known as seasonal affective disorder (SAD), has evoked substantial research in the last two decades...
  32. pmc What is the optimal implementation of bright light therapy for seasonal affective disorder (SAD)?
    Robert D Levitan
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 30:72. 2005
  33. doi An overview of seasonal affective disorder and its treatment options
    Robert H Howland
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Phys Sportsmed 37:104-15. 2009
    b>Seasonal affective disorder (SAD) is defined as a history of major depressive episodes that recur regularly at a particular time of year...
  34. doi Improvement in depression scores after 1 hour of light therapy treatment in patients with seasonal affective disorder
    Gloria M Reeves
    Department of Psychiatry, Child and Adolescent Psychiatry Division, University of Maryland School of Medicine, 701 W Pratt Street, Baltimore, MD 21201, USA
    J Nerv Ment Dis 200:51-5. 2012
    ..study was to investigate possible rapid effects of light therapy on depressed mood in patients with seasonal affective disorder. Participants received 1 hour of bright light therapy and 1 hour of placebo dim red light in a ..
  35. ncbi Night eating syndrome and winter seasonal affective disorder
    Serge Friedman
    Clinique des Maladies Mentales et de l Encéphale CMME, Centre Hospitalier Sainte Anne, Universite Paris V, René Descartes, France
    Appetite 47:119-22. 2006
    Night eating syndrome (NES) and winter seasonal affective disorder (SAD) share some features such as snacking for high-carbohydrate/high-fat food with increased weight, emotional distress, circadian disturbances, good response to ..
  36. doi Complex interaction of circadian and non-circadian effects of light on mood: shedding new light on an old story
    Kathryn M Stephenson
    Department of Biological Rhythms, Institut des Neurosciences Cellulaires et Integratives, CNRS UPR 3212, Strasbourg, France
    Sleep Med Rev 16:445-54. 2012
    ..Such research could improve therapeutic management of affective disorders and influence the management of societal lighting conditions...
  37. ncbi Seasonal affective disorder
    John M Eagles
    Royal Cornhill Hospital, Cornhill Road, Aberdeen AB25 2ZH, UK
    Br J Psychiatry 182:174-6. 2003
  38. ncbi Therapeutic mechanism in seasonal affective disorder: do fluoxetine and light operate through advancing circadian phase?
    Greg Murray
    Faculty of Life and Social Sciences, Swinburne University of Technology, Melbourne, Victoria, Australia
    Chronobiol Int 22:937-43. 2005
    ..of Lewy's phase delay hypothesis, the present study tested whether effective treatment of winter Seasonal Affective Disorder (SAD) is mediated by advancing of circadian phase...
  39. ncbi Bright light therapy for winter depression--is phase advancing beneficial?
    Helen J Burgess
    Biological Rhythms Research Laboratory, Department of Psychology, Rush University Medical Center, Chicago, IL 60612, USA
    Chronobiol Int 21:759-75. 2004
    Bright light is the recommended treatment for winter seasonal affective disorder (SAD). Previously we showed that the antidepressant effect of morning (but not evening) light was greater than placebo after 3 weeks of treatment...
  40. doi Evidence of a biological effect of light therapy on the retina of patients with seasonal affective disorder
    Marie Pier Lavoie
    Centre de Recherche Universite Laval Robert Giffard, Centre hospitalier de l Universite Laval, Quebec G1J 2G3, Canada
    Biol Psychiatry 66:253-8. 2009
    Retinal sensitivity anomalies have been reported in patients affected by seasonal affective disorder (SAD)...
  41. ncbi Monoaminergic function in the pathogenesis of seasonal affective disorder
    A Neumeister
    National Institutes of Health, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Int J Neuropsychopharmacol 4:409-20. 2001
    b>Seasonal affective disorder/winter type (SAD) is characterized by recurrent depressive episodes during autumn and winter alternating with non-depressive episodes during spring and summer...
  42. ncbi Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, B C, Canada
    Neuropsychopharmacology 25:S97-101. 2001
    Noradrenergic and dopaminergic mechanisms have been proposed for the pathophysiology of seasonal affective disorder (SAD)...
  43. ncbi A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesis
    Robert D Levitan
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 31:2498-503. 2006
    ..7-repeat allele (7R) of the dopamine-4 receptor gene (DRD4), weight gain, and obesity in women with seasonal affective disorder (SAD)...
  44. ncbi Light therapy for seasonal affective disorder in primary care: randomised controlled trial
    S M Wileman
    Health Services Research Unit, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Br J Psychiatry 178:311-6. 2001
    ..Studies of light therapy have not been conducted previously in primary care...
  45. ncbi Immune-inflammatory markers in patients with seasonal affective disorder: effects of light therapy
    S J Leu
    Graduate Institute of Cell and Molecule Biology, Taipei Medical College, Taipei, Taiwan, ROC
    J Affect Disord 63:27-34. 2001
    ..The purposes of this study were to (1) compare immune-inflammatory markers in patients with seasonal affective disorder (SAD) with those in matched normal controls; and (2) examine the effects of light therapy on the immune-..
  46. doi Narrow-band blue-light treatment of seasonal affective disorder in adults and the influence of additional nonseasonal symptoms
    Robert E Strong
    Mood Disorders Clinic, Department of Psychiatry, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Depress Anxiety 26:273-8. 2009
    Bright visible-spectrum light therapy has proven effective in the treatment of seasonal affective disorder (SAD) and recent basic research suggests that blue wavelengths approximately 470 nm account for that effectiveness...
  47. ncbi Which environmental variables are related to the onset of seasonal affective disorder?
    M A Young
    Institute of Psychology, Illinois Institute of Technology, Chicago 60616 3793, USA
    J Abnorm Psychol 106:554-62. 1997
    The regular fall-winter onset of seasonal affective disorder is believed to be related to seasonal changes in the environment...
  48. ncbi Effects of light treatment on sleep structure in seasonal affective disorder
    T Partonen
    Ullanlinna Sleep Disorders Clinic and Research Centre, Helsinki, Finland
    Eur Arch Psychiatry Clin Neurosci 242:310-3. 1993
    Twelve outpatients with seasonal affective disorder (depression, winter type) were treated by 1 h of bright light exposure for five mornings...
  49. ncbi Quality of life as an outcome indicator in patients with seasonal affective disorder: results from the Can-SAD study
    Erin E Michalak
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychol Med 37:727-36. 2007
    ..the relationship between quality of life (QoL) and non-seasonal depression, few have measured QoL in seasonal affective disorder (SAD)...
  50. doi Lux vs. wavelength in light treatment of Seasonal Affective Disorder
    J L Anderson
    Department of Psychiatry, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Acta Psychiatr Scand 120:203-12. 2009
    Published dosing guidelines for treatment of Seasonal Affective Disorder (SAD) refer to photopic lux, which is not appropriate for short-wavelength light. Short wavelengths are most potent for many non-visual responses to light...
  51. ncbi Light room therapy effective in mild forms of seasonal affective disorder--a randomised controlled study
    C Rastad
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    J Affect Disord 108:291-6. 2008
    The most common way to provide bright light therapy to Swedish patients with Seasonal Affective Disorder (SAD), is treatment in a light therapy room...
  52. pmc Effect of simulated dawn on quality of sleep--a community-based trial
    Sami Leppämäki
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 3:14. 2003
    Morning light exposure administered as simulated dawn looks a promising method to treat Seasonal Affective Disorder, but it may moreover help with resetting the inaccurate organisation of body clock functions relative to sleep occurring ..
  53. ncbi Sand rats see the light: short photoperiod induces a depression-like response in a diurnal rodent
    Haim Einat
    University of Minnesota, College of Pharmacy, Duluth, MN 55812, USA
    Behav Brain Res 173:153-7. 2006
    ..g., SAD), which in humans is a prevalent disorder, with winter depression episodes and spring/summer remissions...
  54. ncbi A randomized controlled trial of cognitive-behavioral therapy, light therapy, and their combination for seasonal affective disorder
    Kelly J Rohan
    Department of Psychology, University of Vermont, Burlington, VT 05405 0134, USA
    J Consult Clin Psychol 75:489-500. 2007
    This first controlled psychotherapy trial for seasonal affective disorder (SAD) compared SAD-tailored cognitive-behavioral therapy (CBT), light therapy (LT), and their combination to a concurrent wait-list control...
  55. ncbi Serotonin transporter promoter gene polymorphic region (5-HTTLPR) and personality in female patients with seasonal affective disorder and in healthy controls
    Nikolaus Thierry
    Department of General Psychiatry, Waehringer Guertel 18 20, University of Vienna, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 14:53-8. 2004
    Serotonergic pathways have been related to altered personality patterns in seasonal affective disorder (SAD)...
  56. pmc A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD)
    Paul H Desan
    Department of Psychiatry, Yale University, New Haven, CT 06520 8068, USA
    BMC Psychiatry 7:38. 2007
    ..Light treatment devices using efficient light-emitting diodes (LEDs) whose output is relatively concentrated in short wavelengths may enable a more convenient effective therapy for Seasonal Affective Disorder (SAD).
  57. ncbi Extraocular light therapy in winter depression: a double-blind placebo-controlled study
    K M Koorengevel
    Department of Psychiatry, Groningen, The Netherlands
    Biol Psychiatry 50:691-8. 2001
    BACKGROUND: It has been hypothesized that the circadian pacemaker is phase delayed in seasonal affective disorder, (SAD) winter type, and that the phase advance resulting from morning ocular light accounts for the efficacy of light ..
  58. ncbi Light treatment for nonseasonal depression: speed, efficacy, and combined treatment
    D F Kripke
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0667, USA
    J Affect Disord 49:109-17. 1998
    ..Using bright light for treating major depressive disorders which are not seasonal needs reassessment...
  59. ncbi The diagnosis, symptomatology, and epidemiology of seasonal affective disorder
    Andres Magnusson
    Department of Psychiatry, Aker University Hospital, Oslo, Norway
    CNS Spectr 10:625-34; quiz 1-14. 2005
    The operational criteria for seasonal affective disorder (SAD) have undergone several changes since first proposed in 1984...
  60. ncbi Measuring seasonality: psychometric properties of the Seasonal Pattern Assessment Questionnaire and the Inventory for Seasonal Variation
    Michael A Young
    Institute of Psychology, Illinois Institute of Technology, 3101 S Dearborn Avenue, Chicago 60616, USA
    Psychiatry Res 117:75-83. 2003
    ..Given the long history of its use and some small psychometric and simplicity advantages for the SPAQ, its continued use as a dimensional measure of seasonality is indicated...
  61. ncbi Update on the biology of seasonal affective disorder
    Chang Ho Sohn
    Mood Disorders Centre, University of British Columbia Hospital, Vancouver, British Columbia, Canada
    CNS Spectr 10:635-46; quiz 1-14. 2005
    The etiology and pathophysiology of seasonal affective disorder (SAD) has been linked to the seasons and to light since its first conceptualization...
  62. ncbi Quality of life in patients with seasonal affective disorder: summer vs winter scores
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 50:292-5. 2005
    To compare perceived quality of life (QoL) in patients diagnosed with seasonal affective disorder (SAD) during the winter and summer months.
  63. ncbi Effect of light therapy on biopterin, neopterin and tryptophan in patients with seasonal affective disorder
    Rocco Hoekstra
    DeltaBouman Psychiatric Teaching Hospital, Postbus 800, Poortugaal 3170 DZ, The Netherlands
    Psychiatry Res 120:37-42. 2003
    The serotonergic system is believed to play a key role in the pathophysiology of seasonal affective disorder (SAD)...
  64. ncbi Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder
    R D Levitan
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Canada
    Neuropsychopharmacology 29:179-86. 2004
    There is significant evidence that altered dopamine activity plays a role in seasonal affective disorder (SAD)...
  65. ncbi Actigraphy in patients with seasonal affective disorder and healthy control subjects treated with light therapy
    Dietmar Winkler
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Biol Psychiatry 58:331-6. 2005
    Abnormalities of the circadian rest-activity cycle are hypothesized to accompany the clinical picture of seasonal affective disorder (SAD)...
  66. ncbi Seasonal affective disorder: a vestigial evolutionary advantage?
    J M Eagles
    Royal Cornhill Hospital, Block A, Clerkseat Building, Cornhill Road, Aberdeen AB25 2ZH, UK
    Med Hypotheses 63:767-72. 2004
    ..Hypomania in spring and summer also served to increase the likelihood of procreation at the optimal time of year. In the modern era, it is probable that recurrent winter depression is becoming a reproductive disadvantage...
  67. ncbi A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder
    M Willeit
    Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria
    Mol Psychiatry 8:942-6. 2003
    Serotonergic mechanisms are thought to play an important role in the pathogenesis of seasonal affective disorder (SAD)...
  68. ncbi Alcoholism and seasonal affective disorder
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Compr Psychiatry 45:51-6. 2004
    ..They may be self-medicating an underlying seasonal affective disorder (SAD) with alcohol or manifesting a seasonal pattern to alcohol-induced depression...
  69. ncbi Treatment of seasonal affective disorder
    Dietmar Winkler
    Medical University of Vienna, Department of General Psychiatry Währinger Gürtel 18 20 A 1090 Vienna, Austria
    Expert Rev Neurother 6:1039-48. 2006
    b>Seasonal affective disorder (SAD), winter type, is characterized by the regular annual onset of major depressive episodes during fall or winter, followed by spontaneous remission and sometimes hypomanic or manic episodes during spring ..
  70. ncbi Seasonal affective disorder
    T Partonen
    Department of Psychiatry, University of Helsinki, National Public Health Institute, Finland
    Lancet 352:1369-74. 1998
    b>Seasonal affective disorder (SAD) is a form of recurrent depressive or bipolar disorder, with episodes that vary in severity. Seasonal patterns of depressive episodes are common, but SAD seems to be less common than such patterns suggest...
  71. ncbi O sweet spot where art thou? Light treatment of Seasonal Affective Disorder and the circadian time of sleep
    Greg Murray
    Faculty of Life and Social Sciences, Swinburne University of Technology, PO Box 218 John St, Hawthorn 3122 Melbourne, Victoria, Australia
    J Affect Disord 90:227-31. 2006
    This study investigated Lewy's Phase Shift Hypothesis (PSH) for winter Seasonal Affective Disorder, which asserts that the phase angle difference (PAD) between circadian and sleep rhythms is critical in the mechanism of light's ..
  72. ncbi Electroretinography in patients with winter seasonal affective disorder
    Marc Hebert
    Department of Ophthalmology, Laval University Medical Research Center CHUQ, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Psychiatry Res 127:27-34. 2004
    A retinal sensitivity abnormality has been hypothesized in seasonal affective disorder (SAD). To explore this hypothesis, the electroretinogram (ERG) was used to assess retinal sensitivity at the level of the rod photoreceptor system...
  73. pmc The circadian basis of winter depression
    Alfred J Lewy
    Sleep and Mood Disorders Laboratory, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 103:7414-9. 2006
    The following test of the circadian phase-shift hypothesis for patients with winter depression (seasonal affective disorder, or SAD) uses low-dose melatonin administration in the morning or afternoon/evening to induce phase delays or ..
  74. ncbi Light therapy for seasonal affective disorder with blue narrow-band light-emitting diodes (LEDs)
    Gena Glickman
    Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Biol Psychiatry 59:502-7. 2006
    While light has proven an effective treatment for Seasonal Affective Disorder (SAD), an optimal wavelength combination has not been determined...
  75. ncbi Serum lipid levels in seasonal affective disorder
    Edda Pjrek
    Dept of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 257:197-202. 2007
    ..The aim of this pilot study was to examine serum lipids in a sample of patients suffering from seasonal affective disorder (SAD)...
  76. doi Treatment of seasonal affective disorder with duloxetine: an open-label study
    E Pjrek
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Pharmacopsychiatry 41:100-5. 2008
    The aim of this observational study was to evaluate the effects of duloxetine in the treatment of seasonal affective disorder (SAD).
  77. ncbi [Overlap between atypical depression, seasonal affective disorder and chronic fatigue syndrome]
    Mario Francisco Juruena
    Seção de Neurobiologia dos Transtornos de Humor, Instituto de Psiquiatria, King s College, Universidade de Londres, UK
    Rev Bras Psiquiatr 29:S19-26. 2007
    ..Patients with atypical depression, seasonal affective disorder and chronic fatigue syndrome fall in this category.
  78. ncbi The impact of latitude on the prevalence of seasonal depression
    Anthony J Levitt
    Department of Psychiatry, Department of Nutritional Sciences, Fellowship Program, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario
    Can J Psychiatry 47:361-7. 2002
    ..This study sought to determine whether the prevalence of the seasonal subtype of major depression (SAD) in the community varied as a function of latitude...
  79. ncbi Dopamine transporter availability in symptomatic depressed patients with seasonal affective disorder and healthy controls
    A Neumeister
    Department of General Psychiatry, University of Vienna, Austria
    Psychol Med 31:1467-73. 2001
    BACKGROUND: During recent years hypotheses about the pathophysiology of seasonal affective disorder/winter type (SAD) have focused monoaminergic mechanisms. There is substantial evidence that serotonergic systems play an important role...
  80. ncbi Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression
    Timo Partonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Ann Med 39:229-38. 2007
    ..of evidence suggest that the circadian clock contributes to the pathogenesis of winter depression or seasonal affective disorder (SAD)...
  81. ncbi What is this thing called "SAD"? A critique of the concept of Seasonal Affective Disorder
    Vidje Hansen
    Institute of Clinical Medicine, University of Tromsø, Norway
    Epidemiol Psichiatr Soc 17:120-7. 2008
    b>Seasonal Affective Disorder (SAD) is supposed to be caused by lack of daylight in winter...
  82. ncbi Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorder
    Nicole Praschak-Rieder
    Department of General Psychiatry, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 12:129-34. 2002
    b>Seasonal affective disorder (SAD) and premenstrual dysphoric disorder (PMDD) share many clinical features, and have been associated with brain serotonin dysfunction. Females with SAD frequently fulfil the diagnostic criteria for PMDD...
  83. ncbi Bright light therapy of subsyndromal seasonal affective disorder in the workplace: morning vs. afternoon exposure
    D H Avery
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA 98104, USA
    Acta Psychiatr Scand 103:267-74. 2001
    OBJECTIVE: Bright light therapy in seasonal affective disorder (SAD) has been studied extensively. However, little attention has been given to subsyndromal seasonal affective disorder (SSAD) or the use of bright light in the workplace...
  84. ncbi Seasonal affective disorder and serotonin-related polymorphisms
    C Johansson
    Neurogenetics Unit, Karolinska Institutet and Karolinska Hospital, Stockholm, S 171 76, Sweden
    Neurobiol Dis 8:351-7. 2001
    Disturbances in central serotonergic systems have been hypothesized to be involved in seasonal affective disorder (SAD)...
  85. ncbi A circadian signal of change of season in patients with seasonal affective disorder
    T A Wehr
    Section o Biological Rhythms, Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1390, USA
    Arch Gen Psychiatry 58:1108-14. 2001
    ..We investigated whether such a signal could mediate the effects of change of season on patients with seasonal affective disorder. METHODS: The duration of melatonin secretion in constant dim light was measured in winter and in ..
  86. ncbi Effects of tryptophan depletion vs catecholamine depletion in patients with seasonal affective disorder in remission with light therapy
    A Neumeister
    National Institute of Mental Health, Clinical Psychobiology Branch, Bethesda, MD, USA
    Arch Gen Psychiatry 55:524-30. 1998
    ..Although hypotheses about the therapeutic mechanism of action of light therapy have focused on serotonergic mechanisms, the potential role, if any, of catecholaminergic pathways has not been fully explored...
  87. pmc The chronobiology and neurobiology of winter seasonal affective disorder
    Robert D Levitan
    Department of Psychiatry, University of Toronto, Canada
    Dialogues Clin Neurosci 9:315-24. 2007
    This review summarizes research on the chronobiology and neurobiology of winter seasonal affective disorder (SAD), a recurrent subtype of depression characterized by a predictable onset in the fall/winter months and spontaneous remission ..
  88. ncbi Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder
    N E Rosenthal
    National Institute of Mental Health, Clinical Psychobiology Branch, Bethesda, MD 20892 1390, USA
    Mol Psychiatry 3:175-7. 1998
    Seasonal variations in mood and behavior (seasonality) and seasonal affective disorder (SAD) have been attributed to seasonal fluctuations in brain serotonin (5-HT)...
  89. ncbi Prevalence of seasonal affective disorder in primary care; a comparison of the seasonal health questionnaire and the seasonal pattern assessment questionnaire
    Chris Thompson
    Community Clinical Sciences Research Division, University of Southampton, Royal South Hants Hospital, Brinton s Terrace, Southampton SO19 4YP, UK
    J Affect Disord 78:219-26. 2004
    ..The Seasonal Health Questionnaire (SHQ) was designed to better reflect the clinical criteria for SAD and has been shown to have a higher specificity then the SPAQ in a psychiatric outpatient setting...
  90. doi The prevalence of seasonal affective disorder (SAD) in Greenland is related to latitude
    Mogens Kegel
    Department of Psychiatry, Ballerup, Ballerup Boulevard 2, Ballerup 2750, Denmark
    Nord J Psychiatry 63:331-5. 2009
    The aim of this study was to determine the prevalence of seasonal affective disorder (SAD) in Greenlanders and Danes living at four different latitudes in Greenland...
  91. ncbi Epidemiology, etiology, and natural treatment of seasonal affective disorder
    Alan L Miller
    Thorne Research, Inc, PO Box 25, Dover, ID 83825, USA
    Altern Med Rev 10:5-13. 2005
    ..persist in the winter, abate as the days grow longer, and disappear in the summer, the diagnosis of seasonal affective disorder (SAD) can be made...
  92. ncbi Seasonal affective disorder: the latitude hypothesis revisited
    Erin E Michalak
    Can J Psychiatry 47:787-8. 2002
  93. ncbi Agomelatine in the treatment of seasonal affective disorder
    Edda Pjrek
    Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Psychopharmacology (Berl) 190:575-9. 2007
    ..Previous studies showed that agomelatine is able to restore disrupted circadian rhythms, which were implicated in the pathophysiology of seasonal affective disorder (SAD).
  94. pmc Pathophysiology of seasonal affective disorder: a review
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, BC
    J Psychiatry Neurosci 25:469-80. 2000
    The study of the pathophysiology of seasonal affective disorder (SAD, also known as winter depression) has historically been intimately linked to investigations into the mechanisms of action of light therapy...
  95. ncbi Cognitive-behavioral factors in seasonal affective disorder
    Kelly J Rohan
    Department of Psychology, University of Maine, USA
    J Consult Clin Psychol 71:22-30. 2003
    To longitudinally examine cognitive-behavioral correlates of seasonal affective disorder (SAD), the authors assessed women with a history of SAD and nondepressed, matched controls across fall, winter, and summer...
  96. ncbi A forced desynchrony study of circadian pacemaker characteristics in seasonal affective disorder
    Kathelijne M Koorengevel
    Department of Psychiatry, University of Groningen, Haren, The Netherlands
    J Biol Rhythms 17:463-75. 2002
    ..of symptoms and the efficacy of light therapy suggest involvement of the circadian pacemaker in seasonal affective disorder (SAD), winter type...
  97. ncbi The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality
    C Johansson
    Department of Molecular Medicine, Karolinska Institute and Karolinska Hospital, Stockholm, Sweden
    Psychol Med 33:785-92. 2003
    ..association studies of the serotonin transporter promoter repeat length polymorphism (5-HTTLPR), seasonal affective disorder (SAD) and seasonality (seasonal variations in mood and behaviour)...
  98. ncbi Seasonality and seasonal affective disorder (SAD): an evolutionary viewpoint tied to energy conservation and reproductive cycles
    Caroline Davis
    York University, 343 Bethune College, 4700 Keele Street, Toronto, ON, Canada M3J 1P3
    J Affect Disord 87:3-10. 2005
    ..The adaptive value of such a pattern, and its putative role in natural selection in humans, is also discussed...
  99. ncbi Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference
    Carolina Johansson
    Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 28:734-9. 2003
    Disturbed circadian rhythms have been observed in seasonal affective disorder (SAD)...
  100. ncbi [Platelet serotonin transport in the group of outpatients with seasonal affective disorder before and after light treatment, and in remission (in the summer)]
    Lukasz Swiecicki
    II Klinika Psychiatryczna IPiN, Warszawie
    Psychiatr Pol 39:459-68. 2005
    To asses the results of phototherapy on platelet serotonin transport in the group of patients with seasonal affective disorder (SAD), DSM-IV criteria, with complete clinical remission during the summer period.
  101. ncbi More prominent reactivity in mood than activity and sleep induced by differential light exposure due to seasonal and local differences
    Doo Heum Park
    Department of Psychiatry, Konkuk University School of Medicine, Seoul, Korea
    Chronobiol Int 24:905-20. 2007
    ..atypical subscore of the Structured Interview Guide for the Hamilton Depression Rating Scale, Seasonal Affective Disorder version (SIGH-SAD); and actigraphic measures of light exposure and sleep for one-week in each solstice ..

Research Grants79

  1. Sensitization of Human Circadian Responses to Light
    Charles A Czeisler; Fiscal Year: 2010
    ..shift work sleep disorder, and jet lag, and they may also have relevance for the use of light to treat seasonal affective disorder. Up to now, little attention has been paid to the duration or intensity of light exposure prior to such ..
  2. Light Treatment for Winter-SAD: Prediction of Response by Immediate Improvement
    TEODOR POSTOLACHE; Fiscal Year: 2007
    b>Seasonal affective disorder winter type (SAD) consists of episodes of major depression in winter with remission in spring and summer...
  3. INTEGRATING ENERGY STORAGE, HIPPOCAMPUS AND HORMONES
    JEFFREY LUCAS; Fiscal Year: 2002
    b>Seasonal Affective Disorder (SAD) is a seasonal pattern of clinical depression that also correlates with changes in appetite, weight regulation, hormone profiles, and social interactions...
  4. NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONIN
    STEVEN YELLON; Fiscal Year: 2002
    ....
  5. EXTRAOCULAR CIRCADIAN PHOTOTRANSDUCTION IN HUMANS
    Scott Campbell; Fiscal Year: 2001
    DESCRIPTION (applicant's abstract): Circadian rhythm sleep disorders and seasonal affective disorder affect a large number of individuals across a wide age range...
  6. LIGHT THERAPY FOR SEASONAL AFFECTIVE DISORDER
    Michael Terman; Fiscal Year: 1990
    The depressive symptoms of Seasonal Affective Disorder (S.A.D.; Rosenthal et al...
  7. Regulation of Masking and Circadian Rhythm Phase
    Lawrence P Morin; Fiscal Year: 2010
    ..methods of clinical care for persons suffering from such problems as delayed phase sleep syndrome, seasonal affective disorder, inappropriate timing of sleep or other bodily rhythms, it is necessary to understand how photic ..
  8. Regulation of Masking and Circadian Rhythm Phase
    LAWRENCE MORIN; Fiscal Year: 2009
    ..methods of clinical care for persons suffering from such problems as delayed phase sleep syndrome, seasonal affective disorder, inappropriate timing of sleep or other bodily rhythms, it is necessary to understand how photic ..
  9. Role of Kiss1 neurons in the seasonal and circadian control of reproduction
    ALEXANDER KAUFFMAN; Fiscal Year: 2007
    ..and behavior (including critical aspects of reproduction), as well as seasonal traits (such as Seasonal Affective Disorder), increased knowledge of Kissl involvement in circadian and photoperiodic processes could improve our ..
  10. MELATONIN-LIGHT INTERACTION ON CIRCADIAN ACTIVITY
    Margarita Dubocovich; Fiscal Year: 2003
    ....
  11. Behavioral, molecular and genetic studies of VIP in the SCN
    CHRISTOPHER CIARLEGLIO; Fiscal Year: 2007
    ..Circadian clock dysfunction can dramatically affect human health. Seasonal Affective Disorder (SAD), for example, occurs when the human clock gets less light input during the winter months and ..
  12. TREATMENT OF CIRCADIAN SLEEP DISORDERS WITH BRIGHT LIGHT
    Steven W Lockley; Fiscal Year: 2010
    ..treatment of delayed sleep phase disorder, advanced sleep phase disorder, shift-work sleep disorder, jet lag, seasonal affective disorder, "sundowning" in Alzheimer's Disease, and age-related sleep maintenance insomnia.
  13. TREATMENT OF CIRCADIAN SLEEP DISORDERS WITH BRIGHT LIGHT
    CHARLES CZEISLER; Fiscal Year: 2006
    ..the phototherapy treatment of delayed sleep phase disorder, advanced sleep phase disorder, shift-work sleep disorder, jet lag, seasonal affective disorder, "sundowning" in Alzheimer's Disease, and age-related sleep maintenance insomnia.
  14. VARIABLE SPECTRUM LIGHT FIELD FOR THE TREATMENT OF SAD
    Neil Goldman; Fiscal Year: 2002
    DESCRIPTION: Sufferers of Seasonal Affective Disorder respond quickly to light therapy in the fall and winter. Their treatment is usually confined to the home because light boxes are stationary, and head-mounted devices limit visibility...
  15. TREATMENT OF CIRCADIAN SLEEP DISORDERS WITH BRIGHT LIGHT
    CHARLES CZEISLER; Fiscal Year: 2007
    ..the phototherapy treatment of delayed sleep phase disorder, advanced sleep phase disorder, shift-work sleep disorder, jet lag, seasonal affective disorder, "sundowning" in Alzheimer's Disease, and age-related sleep maintenance insomnia.
  16. Modulatory Role of Melatonin on CNS Function
    Margarita Dubocovich; Fiscal Year: 2007
    ..Furthermore, this research will increase our ability to design treatments aimed to alleviate symptoms associate with seasonal affective disorders. ..
  17. LIGHT THERAPY FOR SEASONAL AFFECTIVE DISORDER
    Michael Terman; Fiscal Year: 1993
    Light therapy for winter depression (Seasonal Affective Disorder, SAD), offers the promise of major alleviation of symptoms of fatigue, hyperphagia, hypersomnia, dysphoria, and anxiety that - according to recent surveys - are experienced ..
  18. Molecular Mechanism of Photoperiodic Time Measurement
    Takato Imaizumi; Fiscal Year: 2007
    ..In people, one example of this is Seasonal Affective Disorder (SAD)...
  19. Physical Activity in relation to Depressive Symptoms in Black U.S Adults
    Elisa Torres; Fiscal Year: 2007
    ..psychological, sociocultural and physical) and situational influence (environmental risk factors for seasonal affective disorder) on the relationship of PA with depressive symptoms, and 3) examining the effects of combined ..
  20. CIRCADIAN REGULATORY CIRCUITS IN DROSOPHILA
    Paul Hardin; Fiscal Year: 2003
    ..Clock dysfunction is related to several common mental disorders such as manic-depressive illness, seasonal affective disorder and insomnia...
  21. Molecular Mechanism of Photoperiodic Time Measurement
    Takato Imaizumi; Fiscal Year: 2007
    ..In people, one example of this is Seasonal Affective Disorder (SAD)...
  22. Clock Genes, Night Work, and Breast Cancer Risk
    Eva Schernhammer; Fiscal Year: 2007
    ..circadian dysrhythmias have been identified, and common mutations of four of those were associated with seasonal affective disorder, familial advanced sleep phase syndrome, and diurnal preference...