seasonal affective disorder

Summary

Summary: A syndrome characterized by depressions that recur annually at the same time each year, usually during the winter months. Other symptoms include anxiety, irritability, decreased energy, increased appetite (carbohydrate cravings), increased duration of sleep, and weight gain. SAD (seasonal affective disorder) can be treated by daily exposure to bright artificial lights (PHOTOTHERAPY), during the season of recurrence.

Top Publications

  1. ncbi The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence
    Robert N Golden
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 162:656-62. 2005
  2. ncbi Light room therapy effective in mild forms of seasonal affective disorder--a randomised controlled study
    C Rastad
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    J Affect Disord 108:291-6. 2008
  3. pmc A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder
    Kathryn A Roecklein
    Graduate Program in Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
    J Affect Disord 114:279-85. 2009
  4. ncbi Depressive symptomatology differentiates subgroups of patients with seasonal affective disorder
    Namni Goel
    Columbia University, New York, New York, USA
    Depress Anxiety 15:34-41. 2002
  5. ncbi Seasonal differences in the diurnal pattern of cortisol secretion in healthy participants and those with self-assessed seasonal affective disorder
    Lisa Thorn
    Department of Psychology, University of Westminster, London, UK
    Psychoneuroendocrinology 36:816-23. 2011
  6. ncbi Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL
    Jack G Modell
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Biol Psychiatry 58:658-67. 2005
  7. ncbi The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality
    C Johansson
    Department of Molecular Medicine, Karolinska Institute and Karolinska Hospital, Stockholm, Sweden
    Psychol Med 33:785-92. 2003
  8. ncbi Enhanced serotonin transporter function during depression in seasonal affective disorder
    Matthaus Willeit
    Department of Biological Psychiatry, Medical University of Vienna, Vienna, Austria
    Neuropsychopharmacology 33:1503-13. 2008
  9. pmc Pathophysiology of seasonal affective disorder: a review
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, BC
    J Psychiatry Neurosci 25:469-80. 2000
  10. ncbi Autobiographical memory style in seasonal affective disorder and its relationship to future symptom remission
    T Dalgeish
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, England
    J Abnorm Psychol 110:335-40. 2001

Detail Information

Publications263 found, 100 shown here

  1. ncbi The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence
    Robert N Golden
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 162:656-62. 2005
    ..The purpose of this study was to assess the evidence base for the efficacy of light therapy in treating mood disorders...
  2. ncbi Light room therapy effective in mild forms of seasonal affective disorder--a randomised controlled study
    C Rastad
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    J Affect Disord 108:291-6. 2008
    The most common way to provide bright light therapy to Swedish patients with Seasonal Affective Disorder (SAD), is treatment in a light therapy room...
  3. pmc A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder
    Kathryn A Roecklein
    Graduate Program in Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
    J Affect Disord 114:279-85. 2009
    ..a non-visual photopigment, may play a role in aberrant responses to low winter light levels in Seasonal Affective Disorder (SAD)...
  4. ncbi Depressive symptomatology differentiates subgroups of patients with seasonal affective disorder
    Namni Goel
    Columbia University, New York, New York, USA
    Depress Anxiety 15:34-41. 2002
    Patients with seasonal affective disorder (SAD) may vary in symptoms of their depressed winter mood state, as we showed previously for nondepressed (manic, hypomanic, hyperthymic, euthymic) springtime states [Goel et al., 1999]...
  5. ncbi Seasonal differences in the diurnal pattern of cortisol secretion in healthy participants and those with self-assessed seasonal affective disorder
    Lisa Thorn
    Department of Psychology, University of Westminster, London, UK
    Psychoneuroendocrinology 36:816-23. 2011
    ..salivary cortisol secretion in winter and in summer between two groups; participants with self-assessed seasonal affective disorder (SAD) and age- and sex-matched healthy controls...
  6. ncbi Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL
    Jack G Modell
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Biol Psychiatry 58:658-67. 2005
    b>Seasonal affective disorder (SAD) can cause significant distress and impairment. No antidepressant studies have previously attempted to prevent the onset of autumn-winter depression.
  7. ncbi The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality
    C Johansson
    Department of Molecular Medicine, Karolinska Institute and Karolinska Hospital, Stockholm, Sweden
    Psychol Med 33:785-92. 2003
    ..association studies of the serotonin transporter promoter repeat length polymorphism (5-HTTLPR), seasonal affective disorder (SAD) and seasonality (seasonal variations in mood and behaviour)...
  8. ncbi Enhanced serotonin transporter function during depression in seasonal affective disorder
    Matthaus Willeit
    Department of Biological Psychiatry, Medical University of Vienna, Vienna, Austria
    Neuropsychopharmacology 33:1503-13. 2008
    ..5-HTT-mediated inward and outward transport in platelets of drug-free depressed patients suffering from seasonal affective disorder (SAD)...
  9. pmc Pathophysiology of seasonal affective disorder: a review
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, BC
    J Psychiatry Neurosci 25:469-80. 2000
    The study of the pathophysiology of seasonal affective disorder (SAD, also known as winter depression) has historically been intimately linked to investigations into the mechanisms of action of light therapy...
  10. ncbi Autobiographical memory style in seasonal affective disorder and its relationship to future symptom remission
    T Dalgeish
    Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, England
    J Abnorm Psychol 110:335-40. 2001
    Autobiographical memory was examined in participants with seasonal affective disorder (SAD). In Experiment 1, participants with SAD performed an autobiographical memory task (AMT) in the winter, when depressed...
  11. ncbi A randomized, placebo-controlled trial of bright light and high-density negative air ions for treatment of Seasonal Affective Disorder
    Randall Flory
    Department of Psychology, Hollins University, Roanoke, VA 24020, USA
    Psychiatry Res 177:101-8. 2010
    ..ions, and the efficacy of two placebo treatments, dim red light and low-density negative ions, for Seasonal Affective Disorder (SAD)...
  12. ncbi Potential animal models of seasonal affective disorder
    Joanna L Workman
    Department of Psychology, The Ohio State University, Columbus, OH 43201, USA
    Neurosci Biobehav Rev 35:669-79. 2011
    b>Seasonal affective disorder (SAD) is characterized by depressive episodes during winter that are alleviated during summer and by morning bright light treatment. Currently, there is no animal model of SAD...
  13. ncbi Winter seasonal affective disorder: a follow-up study of the first 59 patients of the National Institute of Mental Health Seasonal Studies Program
    P J Schwartz
    Clinical Psychobiology Branch, NIMH, Bethesda, MD 20892, USA
    Am J Psychiatry 153:1028-36. 1996
    The purpose of this study was to characterize the long-term course of patients with seasonal affective disorder.
  14. ncbi Controlled trial of naturalistic dawn simulation and negative air ionization for seasonal affective disorder
    Michael Terman
    Department of Biopsychology, New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Psychiatry 163:2126-33. 2006
    ..This trial assessed two novel nonpharmaceutical treatments for winter depression-naturalistic dawn simulation and high-density negative air ionization-delivered during the final hours of sleep...
  15. ncbi Circadian time of morning light administration and therapeutic response in winter depression
    J S Terman
    New York State Psychiatric Institute, 1051 Riverside Dr, Unit 50, New York, NY 10032, USA
    Arch Gen Psychiatry 58:69-75. 2001
    ..METHODS: Plasma melatonin was sampled in 42 patients with seasonal affective disorder, in the evening or overnight while depressed and after 10 to 14 days of light therapy (10 000 lux for ..
  16. ncbi A controlled trial of timed bright light and negative air ionization for treatment of winter depression
    M Terman
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York 10032, USA
    Arch Gen Psychiatry 55:875-82. 1998
    Artificial bright light presents a promising nonpharmacological treatment for seasonal affective disorder. Past studies, however, have lacked adequate placebo controls or sufficient power to detect group differences...
  17. ncbi Bright light treatment of winter depression: a placebo-controlled trial
    C I Eastman
    Department of Psychology, Rush Presbyterian St Luke s Medical Center, Chicago, Ill 60612, USA
    Arch Gen Psychiatry 55:883-9. 1998
    Bright light therapy is the recommended treatment for winter seasonal affective disorder (SAD)...
  18. ncbi The Can-SAD study: a randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder
    Raymond W Lam
    Mood Disorders Centre, UBC Hospital, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1
    Am J Psychiatry 163:805-12. 2006
    Light therapy and antidepressants have shown comparable efficacy in separate studies of seasonal affective disorder treatment, but few studies have directly compared the two treatments...
  19. ncbi Winter depression recurrence one year after cognitive-behavioral therapy, light therapy, or combination treatment
    Kelly J Rohan
    Department of Psychology, University of Vermont, John Dewey Hall, 2 Colchester Avenue, Burlington, VT 05405 0134, USA
    Behav Ther 40:225-38. 2009
    The central public health challenge in the management of seasonal affective disorder (SAD) is prevention of depression recurrence each fall/winter season...
  20. ncbi Dopamine transporter availability in symptomatic depressed patients with seasonal affective disorder and healthy controls
    A Neumeister
    Department of General Psychiatry, University of Vienna, Austria
    Psychol Med 31:1467-73. 2001
    BACKGROUND: During recent years hypotheses about the pathophysiology of seasonal affective disorder/winter type (SAD) have focused monoaminergic mechanisms. There is substantial evidence that serotonergic systems play an important role...
  21. pmc The chronobiology and neurobiology of winter seasonal affective disorder
    Robert D Levitan
    Department of Psychiatry, University of Toronto, Canada
    Dialogues Clin Neurosci 9:315-24. 2007
    This review summarizes research on the chronobiology and neurobiology of winter seasonal affective disorder (SAD), a recurrent subtype of depression characterized by a predictable onset in the fall/winter months and spontaneous remission ..
  22. ncbi Dawn simulation and bright light in the treatment of SAD: a controlled study
    D H Avery
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Harborview Medical Center, Seattle, Washington 98104-2499, USA
    Biol Psychiatry 50:205-16. 2001
    BACKGROUND: Some small controlled studies have found that dawn simulation is effective in treating seasonal affective disorder (SAD)...
  23. pmc The post illumination pupil response is reduced in seasonal affective disorder
    KATHRYN ROECKLEIN
    Department of Psychology, University of Pittsburgh, 201S Bouquet St, Pittsburgh, PA 15260, USA Electronic address
    Psychiatry Res 210:150-8. 2013
    Individuals with seasonal affective disorder (SAD) may have a decreased retinal sensitivity in the non-image forming light-input pathway...
  24. ncbi Symptoms of seasonal affective disorder and of obsessive-compulsive disorder reduced by light therapy
    M Brinkhuijsen
    J Affect Disord 74:307-8. 2003
  25. ncbi Can transcranial brain-targeted bright light treatment via ear canals be effective in relieving symptoms in seasonal affective disorder? A pilot study
    Markku Timonen
    University of Oulu, Institute of Health Sciences General Practice, P O Box 5000, FIN 90014 Oulu, Finland
    Med Hypotheses 78:511-5. 2012
    Bright light therapy (BLT) is widely accepted as first-line treatment of seasonal affective disorder (SAD). However, the mechanism of action of BLT is still widely unknown...
  26. ncbi A placebo-controlled study of sertraline in the treatment of outpatients with seasonal affective disorder
    Adam Moscovitch
    Canadian Sleep Institute, Unit 300, 295 Midpark Way, South East, Calgary, Alberta, T2X 2A8, Canada
    Psychopharmacology (Berl) 171:390-7. 2004
    b>Seasonal affective disorder (SAD) is a relatively common cyclical depressive illness characterized by seasonal depressions during winter...
  27. ncbi The effects of blue-enriched light treatment compared to standard light treatment in Seasonal Affective Disorder
    M C M Gordijn
    Department of Psychiatry, University Medical Center Groningen, The Netherlands
    J Affect Disord 136:72-80. 2012
    One of the most frequently investigated hypotheses of the pathophysiology underlying Seasonal Affective Disorder (SAD) is a disturbance of circadian rhythms...
  28. ncbi Cultural variation in seasonal depression: cross-national differences in winter versus summer patterns of seasonal affective disorder
    Joseph Kasof
    Department of Psychology and Social Behavior, School of Social Ecology, University of California, Irvine, California 92697 7085, USA
    J Affect Disord 115:79-86. 2009
    ..seasonally varying levels of ambient sunlight that may underlie regular cycles of mood and behavior in Seasonal Affective Disorder (SAD)...
  29. ncbi Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder
    Erick H Turner
    Section on Biological Rhythms, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland, USA
    J Clin Psychopharmacol 22:216-20. 2002
    ..Depression ratings using the Structured Interview Guide for the Hamilton Depression Rating Scale-Seasonal Affective Disorder Version were performed at baseline and at 3 and 6 days after each intervention...
  30. pmc Delayed sleep phase syndrome is related to seasonal affective disorder
    Heon Jeong Lee
    Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea
    J Affect Disord 133:573-9. 2011
    Both delayed sleep phase syndrome (DSPS) and seasonal affective disorder (SAD) may manifest similar delayed circadian phase problems. However, the relationships and co-morbidity between the two conditions have not been fully studied...
  31. ncbi Bright light therapy in seasonal affective disorder--does it suffice?
    Edda Pjrek
    Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 14:347-51. 2004
    Bright light therapy (BLT) has been proposed as treatment of choice for seasonal affective disorder (SAD). However, conventional antidepressants have also been found to be effective in this condition...
  32. ncbi Seasonal affective disorder and latitude of living
    Greta Brancaleoni
    Department of Clinical Psychiatry, Institute of Clinical Medicine, Faculty of Medicine, University of Tromsø, and Psychiatric Department, University Hospital North, Norway
    Epidemiol Psichiatr Soc 18:336-43. 2009
    Since the importance of latitude of living for the prevalence of Seasonal Affective Disorder (SAD) is unclear, the study aims to test the latitude hypothesis by comparing SAD in two rather similar groups of students living at latitudes ..
  33. ncbi [More than every tenth person have symptoms of seasonal affective disorder]
    Helle Østergaard Madsen
    Psykiatrisk Center København, afdeling O, Rigshospitalet, Edel Sauntés Alle 10, 2100 København Ø, Denmark
    Ugeskr Laeger 173:3013-6. 2011
    b>Seasonal affective disorder is a syndrome of classical depressive symptoms such as reduced energy, initiative and mood combined with atypical symptoms of increased appetite, weight and sleep duration...
  34. ncbi Effect of seasonal affective disorder and pathological tanning motives on efficacy of an appearance-focused intervention to prevent skin cancer
    Joel Hillhouse
    Department of Community Health, East Tennessee State University, Campus Box 70674, Johnson City, TN 37614, USA
    Arch Dermatol 146:485-91. 2010
    To evaluate the robustness of an appearance-focused intervention to prevent skin cancer in individuals reporting seasonal affective disorder (SAD) symptoms and pathological tanning motives.
  35. ncbi Treatment compliance in light therapy: Do patients do as they say they do?
    Erin E Michalak
    J Affect Disord 68:341-2. 2002
  36. ncbi Use of health care services in seasonal affective disorder
    John M Eagles
    Royal Cornhill Hospital, Cornhill Road, Aberdeen AB25 2ZH, Scotland, UK
    Br J Psychiatry 180:449-54. 2002
    Little is known about the presentation and management of seasonal affective disorder (SAD) in primary care.
  37. ncbi Monorhinal odor identification and depression scores in patients with seasonal affective disorder
    T T Postolache
    Section on Biological Rhythms NIMH, Bethesda, MD 20892 1390, USA
    J Affect Disord 56:27-35. 1999
    ..that olfactory deficits may unmask seasonal rhythms in certain individuals, namely those with seasonal affective disorder (SAD)...
  38. pmc Orexinergic signaling mediates light-induced neuronal activation in the dorsal raphe nucleus
    W Adidharma
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Neuroscience 220:201-7. 2012
    b>Seasonal affective disorder (SAD), a major depressive disorder recurring in the fall and winter, is caused by the reduction of light in the environment, and its depressive symptoms can be alleviated by bright light therapy...
  39. ncbi Comparison of consultation rates in primary care attenders with and without seasonal affective disorder
    J E Andrew
    Health Services Research Unit, Aberdeen University, Aberdeen AB25 2ZD, UK
    J Affect Disord 62:199-205. 2001
    BACKGROUND: There is a lack of published information about the consultation patterns of patients with seasonal affective disorder (SAD) in primary care, when compared with non-seasonal controls (NSCs)...
  40. ncbi Changes of clinical pattern in seasonal affective disorder (SAD) over time in a German-speaking sample
    D Winkler
    Department of General Psychiatry, University Hospital for Psychiatry, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 252:54-62. 2002
    The goals of this study are to provide estimates of clinical and demographic variables of patients with seasonal affective disorder (SAD) in Germany and Austria, to compare our results with those of previously published SAD studies, and ..
  41. ncbi Negative ion treatment increases positive emotional processing in seasonal affective disorder
    C J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychol Med 42:1605-12. 2012
    ..High-density negative ion (HDNI) treatment is an environmental manipulation that has efficacy in randomized clinical trials in seasonal affective disorder (SAD).
  42. ncbi Cognitive-behavioral therapy, light therapy, and their combination in treating seasonal affective disorder
    Kelly J Rohan
    Uniformed Services University of the Health Sciences, Department of Medical and Clinical Psychology, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    J Affect Disord 80:273-83. 2004
    The need to develop supplementary or alternative treatments for seasonal affective disorder (SAD) is underscored by the significant minority (47%) of SAD patients that is refractory to light therapy, the persistence of residual symptoms ..
  43. ncbi Effects of tryptophan depletion on drug-free patients with seasonal affective disorder during a stable response to bright light therapy
    A Neumeister
    Department of General Psychiatry, Vienna University, Austria
    Arch Gen Psychiatry 54:133-8. 1997
    A dysfunction of the serotonin system may play a major role in the pathogenesis of seasonal affective disorder. Bright light therapy has been shown to be effective in the treatment of winter depression in patients with seasonal affective ..
  44. ncbi Atypical pattern of rod electroretinogram modulation by recent light history: a possible biomarker of seasonal affective disorder
    Anne Marie Gagné
    Research Center University Laval Robert Giffard, Quebec, QC, Canada
    Psychiatry Res 187:370-4. 2011
    ..Retinal response modulation may represent an interesting biomarker of the disease for future research...
  45. ncbi Bright light therapy for winter depression--is phase advancing beneficial?
    Helen J Burgess
    Biological Rhythms Research Laboratory, Department of Psychology, Rush University Medical Center, Chicago, IL 60612, USA
    Chronobiol Int 21:759-75. 2004
    Bright light is the recommended treatment for winter seasonal affective disorder (SAD). Previously we showed that the antidepressant effect of morning (but not evening) light was greater than placebo after 3 weeks of treatment...
  46. pmc What is the optimal implementation of bright light therapy for seasonal affective disorder (SAD)?
    Robert D Levitan
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 30:72. 2005
  47. ncbi Improvement in depression scores after 1 hour of light therapy treatment in patients with seasonal affective disorder
    Gloria M Reeves
    Department of Psychiatry, Child and Adolescent Psychiatry Division, University of Maryland School of Medicine, 701 W Pratt Street, Baltimore, MD 21201, USA
    J Nerv Ment Dis 200:51-5. 2012
    ..study was to investigate possible rapid effects of light therapy on depressed mood in patients with seasonal affective disorder. Participants received 1 hour of bright light therapy and 1 hour of placebo dim red light in a ..
  48. ncbi Therapeutic mechanism in seasonal affective disorder: do fluoxetine and light operate through advancing circadian phase?
    Greg Murray
    Faculty of Life and Social Sciences, Swinburne University of Technology, Melbourne, Victoria, Australia
    Chronobiol Int 22:937-43. 2005
    ..of Lewy's phase delay hypothesis, the present study tested whether effective treatment of winter Seasonal Affective Disorder (SAD) is mediated by advancing of circadian phase...
  49. ncbi Evidence of a biological effect of light therapy on the retina of patients with seasonal affective disorder
    Marie Pier Lavoie
    Centre de Recherche Universite Laval Robert Giffard, Centre hospitalier de l Universite Laval, Quebec G1J 2G3, Canada
    Biol Psychiatry 66:253-8. 2009
    Retinal sensitivity anomalies have been reported in patients affected by seasonal affective disorder (SAD)...
  50. ncbi Complex interaction of circadian and non-circadian effects of light on mood: shedding new light on an old story
    Kathryn M Stephenson
    Department of Biological Rhythms, Institut des Neurosciences Cellulaires et Integratives, CNRS UPR 3212, Strasbourg, France
    Sleep Med Rev 16:445-54. 2012
    ..Such research could improve therapeutic management of affective disorders and influence the management of societal lighting conditions...
  51. ncbi Night eating syndrome and winter seasonal affective disorder
    Serge Friedman
    Clinique des Maladies Mentales et de l Encéphale CMME, Centre Hospitalier Sainte Anne, Universite Paris V, René Descartes, France
    Appetite 47:119-22. 2006
    Night eating syndrome (NES) and winter seasonal affective disorder (SAD) share some features such as snacking for high-carbohydrate/high-fat food with increased weight, emotional distress, circadian disturbances, good response to ..
  52. ncbi Long-term and preventative treatment for seasonal affective disorder
    Asa Westrin
    Department of Clinical Sciences, Division of Psychiatry, Lund University Hospital, Lund, Sweden
    CNS Drugs 21:901-9. 2007
    Recurrent major depressive disorder with regular seasonal patterns, commonly known as seasonal affective disorder (SAD), has evoked substantial research in the last two decades...
  53. ncbi An overview of seasonal affective disorder and its treatment options
    Robert H Howland
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Phys Sportsmed 37:104-15. 2009
    b>Seasonal affective disorder (SAD) is defined as a history of major depressive episodes that recur regularly at a particular time of year...
  54. ncbi Seasonal affective disorder
    John M Eagles
    Royal Cornhill Hospital, Cornhill Road, Aberdeen AB25 2ZH, UK
    Br J Psychiatry 182:174-6. 2003
  55. ncbi Immune-inflammatory markers in patients with seasonal affective disorder: effects of light therapy
    S J Leu
    Graduate Institute of Cell and Molecule Biology, Taipei Medical College, Taipei, Taiwan, ROC
    J Affect Disord 63:27-34. 2001
    ..The purposes of this study were to (1) compare immune-inflammatory markers in patients with seasonal affective disorder (SAD) with those in matched normal controls; and (2) examine the effects of light therapy on the immune-..
  56. ncbi Light therapy for seasonal affective disorder in primary care: randomised controlled trial
    S M Wileman
    Health Services Research Unit, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Br J Psychiatry 178:311-6. 2001
    ..Studies of light therapy have not been conducted previously in primary care...
  57. ncbi Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission
    R W Lam
    Division of Mood Disorders, Department of Psychiatry, University of British Columbia, and UBC Hospital, Vancouver Hospital and Health Sciences Centre, Vancouver, B C, Canada
    Neuropsychopharmacology 25:S97-101. 2001
    Noradrenergic and dopaminergic mechanisms have been proposed for the pathophysiology of seasonal affective disorder (SAD)...
  58. ncbi Monoaminergic function in the pathogenesis of seasonal affective disorder
    A Neumeister
    National Institutes of Health, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Int J Neuropsychopharmacol 4:409-20. 2001
    b>Seasonal affective disorder/winter type (SAD) is characterized by recurrent depressive episodes during autumn and winter alternating with non-depressive episodes during spring and summer...
  59. ncbi Effects of light treatment on sleep structure in seasonal affective disorder
    T Partonen
    Ullanlinna Sleep Disorders Clinic and Research Centre, Helsinki, Finland
    Eur Arch Psychiatry Clin Neurosci 242:310-3. 1993
    Twelve outpatients with seasonal affective disorder (depression, winter type) were treated by 1 h of bright light exposure for five mornings...
  60. ncbi Lux vs. wavelength in light treatment of Seasonal Affective Disorder
    J L Anderson
    Department of Psychiatry, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Acta Psychiatr Scand 120:203-12. 2009
    Published dosing guidelines for treatment of Seasonal Affective Disorder (SAD) refer to photopic lux, which is not appropriate for short-wavelength light. Short wavelengths are most potent for many non-visual responses to light...
  61. ncbi A birth-season/DRD4 gene interaction predicts weight gain and obesity in women with seasonal affective disorder: A seasonal thrifty phenotype hypothesis
    Robert D Levitan
    Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 31:2498-503. 2006
    ..7-repeat allele (7R) of the dopamine-4 receptor gene (DRD4), weight gain, and obesity in women with seasonal affective disorder (SAD)...
  62. ncbi Quality of life as an outcome indicator in patients with seasonal affective disorder: results from the Can-SAD study
    Erin E Michalak
    Division of Clinical Neuroscience, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Psychol Med 37:727-36. 2007
    ..the relationship between quality of life (QoL) and non-seasonal depression, few have measured QoL in seasonal affective disorder (SAD)...
  63. ncbi Which environmental variables are related to the onset of seasonal affective disorder?
    M A Young
    Institute of Psychology, Illinois Institute of Technology, Chicago 60616 3793, USA
    J Abnorm Psychol 106:554-62. 1997
    The regular fall-winter onset of seasonal affective disorder is believed to be related to seasonal changes in the environment...
  64. ncbi Narrow-band blue-light treatment of seasonal affective disorder in adults and the influence of additional nonseasonal symptoms
    Robert E Strong
    Mood Disorders Clinic, Department of Psychiatry, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Depress Anxiety 26:273-8. 2009
    Bright visible-spectrum light therapy has proven effective in the treatment of seasonal affective disorder (SAD) and recent basic research suggests that blue wavelengths approximately 470 nm account for that effectiveness...
  65. ncbi Bright-light therapy in the treatment of mood disorders
    Gerald Pail
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Neuropsychobiology 64:152-62. 2011
    Bright-light therapy (BLT) is established as the treatment of choice for seasonal affective disorder/winter type (SAD)...
  66. pmc The phase shift hypothesis for the circadian component of winter depression
    Alfred J Lewy
    Oregon Health and Science University, Department of Psychiatry, Sleep and Mood Disorders Laboratory, Portland, Oregon, USA
    Dialogues Clin Neurosci 9:291-300. 2007
    ..The leading hypothesis for winter depression (seasonal affective disorder, or SAD) is the phase shift hypothesis (PSH)...
  67. ncbi Serotonin transporter promoter gene polymorphic region (5-HTTLPR) and personality in female patients with seasonal affective disorder and in healthy controls
    Nikolaus Thierry
    Department of General Psychiatry, Waehringer Guertel 18 20, University of Vienna, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 14:53-8. 2004
    Serotonergic pathways have been related to altered personality patterns in seasonal affective disorder (SAD)...
  68. ncbi A randomized controlled trial of cognitive-behavioral therapy, light therapy, and their combination for seasonal affective disorder
    Kelly J Rohan
    Department of Psychology, University of Vermont, Burlington, VT 05405 0134, USA
    J Consult Clin Psychol 75:489-500. 2007
    This first controlled psychotherapy trial for seasonal affective disorder (SAD) compared SAD-tailored cognitive-behavioral therapy (CBT), light therapy (LT), and their combination to a concurrent wait-list control...
  69. pmc A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD)
    Paul H Desan
    Department of Psychiatry, Yale University, New Haven, CT 06520 8068, USA
    BMC Psychiatry 7:38. 2007
    ..Light treatment devices using efficient light-emitting diodes (LEDs) whose output is relatively concentrated in short wavelengths may enable a more convenient effective therapy for Seasonal Affective Disorder (SAD).
  70. pmc Effect of simulated dawn on quality of sleep--a community-based trial
    Sami Leppämäki
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    BMC Psychiatry 3:14. 2003
    Morning light exposure administered as simulated dawn looks a promising method to treat Seasonal Affective Disorder, but it may moreover help with resetting the inaccurate organisation of body clock functions relative to sleep occurring ..
  71. ncbi Extraocular light therapy in winter depression: a double-blind placebo-controlled study
    K M Koorengevel
    Department of Psychiatry, Groningen, The Netherlands
    Biol Psychiatry 50:691-8. 2001
    BACKGROUND: It has been hypothesized that the circadian pacemaker is phase delayed in seasonal affective disorder, (SAD) winter type, and that the phase advance resulting from morning ocular light accounts for the efficacy of light ..
  72. ncbi Sand rats see the light: short photoperiod induces a depression-like response in a diurnal rodent
    Haim Einat
    University of Minnesota, College of Pharmacy, Duluth, MN 55812, USA
    Behav Brain Res 173:153-7. 2006
    ..g., SAD), which in humans is a prevalent disorder, with winter depression episodes and spring/summer remissions...
  73. ncbi A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder
    M Willeit
    Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria
    Mol Psychiatry 8:942-6. 2003
    Serotonergic mechanisms are thought to play an important role in the pathogenesis of seasonal affective disorder (SAD)...
  74. ncbi Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorder
    Nicole Praschak-Rieder
    Department of General Psychiatry, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 12:129-34. 2002
    b>Seasonal affective disorder (SAD) and premenstrual dysphoric disorder (PMDD) share many clinical features, and have been associated with brain serotonin dysfunction. Females with SAD frequently fulfil the diagnostic criteria for PMDD...
  75. ncbi Alcoholism and seasonal affective disorder
    Leo Sher
    Division of Neuroscience, Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Compr Psychiatry 45:51-6. 2004
    ..They may be self-medicating an underlying seasonal affective disorder (SAD) with alcohol or manifesting a seasonal pattern to alcohol-induced depression...
  76. ncbi Light therapy for seasonal affective disorder with blue narrow-band light-emitting diodes (LEDs)
    Gena Glickman
    Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Biol Psychiatry 59:502-7. 2006
    While light has proven an effective treatment for Seasonal Affective Disorder (SAD), an optimal wavelength combination has not been determined...
  77. ncbi Bright light therapy of subsyndromal seasonal affective disorder in the workplace: morning vs. afternoon exposure
    D H Avery
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA 98104, USA
    Acta Psychiatr Scand 103:267-74. 2001
    OBJECTIVE: Bright light therapy in seasonal affective disorder (SAD) has been studied extensively. However, little attention has been given to subsyndromal seasonal affective disorder (SSAD) or the use of bright light in the workplace...
  78. ncbi Seasonal affective disorder and serotonin-related polymorphisms
    C Johansson
    Neurogenetics Unit, Karolinska Institutet and Karolinska Hospital, Stockholm, S 171 76, Sweden
    Neurobiol Dis 8:351-7. 2001
    Disturbances in central serotonergic systems have been hypothesized to be involved in seasonal affective disorder (SAD)...
  79. ncbi Electroretinography in patients with winter seasonal affective disorder
    Marc Hebert
    Department of Ophthalmology, Laval University Medical Research Center CHUQ, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Psychiatry Res 127:27-34. 2004
    A retinal sensitivity abnormality has been hypothesized in seasonal affective disorder (SAD). To explore this hypothesis, the electroretinogram (ERG) was used to assess retinal sensitivity at the level of the rod photoreceptor system...
  80. ncbi Seasonal affective disorder
    T Partonen
    Department of Psychiatry, University of Helsinki, National Public Health Institute, Finland
    Lancet 352:1369-74. 1998
    b>Seasonal affective disorder (SAD) is a form of recurrent depressive or bipolar disorder, with episodes that vary in severity. Seasonal patterns of depressive episodes are common, but SAD seems to be less common than such patterns suggest...
  81. ncbi Seasonal affective disorder: a vestigial evolutionary advantage?
    J M Eagles
    Royal Cornhill Hospital, Block A, Clerkseat Building, Cornhill Road, Aberdeen AB25 2ZH, UK
    Med Hypotheses 63:767-72. 2004
    ..Hypomania in spring and summer also served to increase the likelihood of procreation at the optimal time of year. In the modern era, it is probable that recurrent winter depression is becoming a reproductive disadvantage...
  82. ncbi Actigraphy in patients with seasonal affective disorder and healthy control subjects treated with light therapy
    Dietmar Winkler
    Department of General Psychiatry, Medical University of Vienna, Vienna, Austria
    Biol Psychiatry 58:331-6. 2005
    Abnormalities of the circadian rest-activity cycle are hypothesized to accompany the clinical picture of seasonal affective disorder (SAD)...
  83. ncbi Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression
    Timo Partonen
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Ann Med 39:229-38. 2007
    ..of evidence suggest that the circadian clock contributes to the pathogenesis of winter depression or seasonal affective disorder (SAD)...
  84. ncbi Light treatment for nonseasonal depression: speed, efficacy, and combined treatment
    D F Kripke
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0667, USA
    J Affect Disord 49:109-17. 1998
    ..Using bright light for treating major depressive disorders which are not seasonal needs reassessment...
  85. ncbi [Overlap between atypical depression, seasonal affective disorder and chronic fatigue syndrome]
    Mario Francisco Juruena
    Seção de Neurobiologia dos Transtornos de Humor, Instituto de Psiquiatria, King s College, Universidade de Londres, UK
    Rev Bras Psiquiatr 29:S19-26. 2007
    ..Patients with atypical depression, seasonal affective disorder and chronic fatigue syndrome fall in this category.
  86. ncbi The diagnosis, symptomatology, and epidemiology of seasonal affective disorder
    Andres Magnusson
    Department of Psychiatry, Aker University Hospital, Oslo, Norway
    CNS Spectr 10:625-34; quiz 1-14. 2005
    The operational criteria for seasonal affective disorder (SAD) have undergone several changes since first proposed in 1984...
  87. ncbi Quality of life in patients with seasonal affective disorder: summer vs winter scores
    Erin E Michalak
    Department of Psychiatry, University of British Columbia, Vancouver
    Can J Psychiatry 50:292-5. 2005
    To compare perceived quality of life (QoL) in patients diagnosed with seasonal affective disorder (SAD) during the winter and summer months.
  88. ncbi Treatment of seasonal affective disorder
    Dietmar Winkler
    Medical University of Vienna, Department of General Psychiatry Währinger Gürtel 18 20 A 1090 Vienna, Austria
    Expert Rev Neurother 6:1039-48. 2006
    b>Seasonal affective disorder (SAD), winter type, is characterized by the regular annual onset of major depressive episodes during fall or winter, followed by spontaneous remission and sometimes hypomanic or manic episodes during spring ..
  89. ncbi Childhood inattention and dysphoria and adult obesity associated with the dopamine D4 receptor gene in overeating women with seasonal affective disorder
    R D Levitan
    Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Canada
    Neuropsychopharmacology 29:179-86. 2004
    There is significant evidence that altered dopamine activity plays a role in seasonal affective disorder (SAD)...
  90. ncbi What is this thing called "SAD"? A critique of the concept of Seasonal Affective Disorder
    Vidje Hansen
    Institute of Clinical Medicine, University of Tromsø, Norway
    Epidemiol Psichiatr Soc 17:120-7. 2008
    b>Seasonal Affective Disorder (SAD) is supposed to be caused by lack of daylight in winter...
  91. pmc The circadian basis of winter depression
    Alfred J Lewy
    Sleep and Mood Disorders Laboratory, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 103:7414-9. 2006
    The following test of the circadian phase-shift hypothesis for patients with winter depression (seasonal affective disorder, or SAD) uses low-dose melatonin administration in the morning or afternoon/evening to induce phase delays or ..
  92. ncbi The impact of latitude on the prevalence of seasonal depression
    Anthony J Levitt
    Department of Psychiatry, Department of Nutritional Sciences, Fellowship Program, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario
    Can J Psychiatry 47:361-7. 2002
    ..This study sought to determine whether the prevalence of the seasonal subtype of major depression (SAD) in the community varied as a function of latitude...
  93. ncbi O sweet spot where art thou? Light treatment of Seasonal Affective Disorder and the circadian time of sleep
    Greg Murray
    Faculty of Life and Social Sciences, Swinburne University of Technology, PO Box 218 John St, Hawthorn 3122 Melbourne, Victoria, Australia
    J Affect Disord 90:227-31. 2006
    This study investigated Lewy's Phase Shift Hypothesis (PSH) for winter Seasonal Affective Disorder, which asserts that the phase angle difference (PAD) between circadian and sleep rhythms is critical in the mechanism of light's ..
  94. ncbi Update on the biology of seasonal affective disorder
    Chang Ho Sohn
    Mood Disorders Centre, University of British Columbia Hospital, Vancouver, British Columbia, Canada
    CNS Spectr 10:635-46; quiz 1-14. 2005
    The etiology and pathophysiology of seasonal affective disorder (SAD) has been linked to the seasons and to light since its first conceptualization...
  95. ncbi Treatment of seasonal affective disorder with duloxetine: an open-label study
    E Pjrek
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Pharmacopsychiatry 41:100-5. 2008
    The aim of this observational study was to evaluate the effects of duloxetine in the treatment of seasonal affective disorder (SAD).
  96. ncbi Measuring seasonality: psychometric properties of the Seasonal Pattern Assessment Questionnaire and the Inventory for Seasonal Variation
    Michael A Young
    Institute of Psychology, Illinois Institute of Technology, 3101 S Dearborn Avenue, Chicago 60616, USA
    Psychiatry Res 117:75-83. 2003
    ..Given the long history of its use and some small psychometric and simplicity advantages for the SPAQ, its continued use as a dimensional measure of seasonality is indicated...
  97. ncbi Effect of light therapy on biopterin, neopterin and tryptophan in patients with seasonal affective disorder
    Rocco Hoekstra
    DeltaBouman Psychiatric Teaching Hospital, Postbus 800, Poortugaal 3170 DZ, The Netherlands
    Psychiatry Res 120:37-42. 2003
    The serotonergic system is believed to play a key role in the pathophysiology of seasonal affective disorder (SAD)...
  98. ncbi Serum lipid levels in seasonal affective disorder
    Edda Pjrek
    Dept of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Eur Arch Psychiatry Clin Neurosci 257:197-202. 2007
    ..The aim of this pilot study was to examine serum lipids in a sample of patients suffering from seasonal affective disorder (SAD)...
  99. ncbi Epidemiology, etiology, and natural treatment of seasonal affective disorder
    Alan L Miller
    Thorne Research, Inc, PO Box 25, Dover, ID 83825, USA
    Altern Med Rev 10:5-13. 2005
    ..persist in the winter, abate as the days grow longer, and disappear in the summer, the diagnosis of seasonal affective disorder (SAD) can be made...
  100. ncbi Cognitive-behavioral factors in seasonal affective disorder
    Kelly J Rohan
    Department of Psychology, University of Maine, USA
    J Consult Clin Psychol 71:22-30. 2003
    To longitudinally examine cognitive-behavioral correlates of seasonal affective disorder (SAD), the authors assessed women with a history of SAD and nondepressed, matched controls across fall, winter, and summer...
  101. ncbi A forced desynchrony study of circadian pacemaker characteristics in seasonal affective disorder
    Kathelijne M Koorengevel
    Department of Psychiatry, University of Groningen, Haren, The Netherlands
    J Biol Rhythms 17:463-75. 2002
    ..of symptoms and the efficacy of light therapy suggest involvement of the circadian pacemaker in seasonal affective disorder (SAD), winter type...

Research Grants62

  1. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen A McClung; Fiscal Year: 2013
    ..in circadian gene function are more prone to developing mood disorders such as bipolar disorder or seasonal affective disorder and these disorders are highly co-morbid with addiction...
  2. Seasonality of Mood: A Genome-Wide Association Study in the Old Order Amish
    Teodor T Postolache; Fiscal Year: 2010
    ..depression syndromes in the fall or winter, with full remission in spring or summer, a condition called seasonal affective disorder winter type (SAD)...
  3. Circadian light entrainment following genetic ablation of retinal glutamate trans
    HEINRICH SELWYN GOMPF; Fiscal Year: 2010
    ....
  4. Structure &Function of Ganglion-Cell Photoreceptors Contributing to Form Vision
    MAUREEN ESTRELLITA ESTEVEZ; Fiscal Year: 2013
    ..body's responses to daylight, these studies are relevant to such public health issues as jet lag, seasonal affective disorder, and alertness during shift work...
  5. Molecular Mechanism of Photoperiodic Time Measurement
    Takato Imaizumi; Fiscal Year: 2013
    ..For humans, seasonal variation in the amount of light causes Seasonal Affective Disorder (SAD), a recurrent subtype of depression...
  6. Sensitization of Human Circadian Responses to Light
    Charles A Czeisler; Fiscal Year: 2013
    ..shift work sleep disorder, and jet lag, and they may also have relevance for the use of light to treat seasonal affective disorder. Up to now, little attention has been paid to the duration or intensity of light exposure prior to such ..
  7. Regulation of Masking and Circadian Rhythm Phase
    Lawrence P Morin; Fiscal Year: 2012
    ..methods of clinical care for persons suffering from such problems as delayed phase sleep syndrome, seasonal affective disorder, inappropriate timing of sleep or other bodily rhythms, it is necessary to understand how photic ..
  8. TRAINING IN METHODS OF COMPUTATIONAL NEUROSCIENCE
    William S Reznikoff; Fiscal Year: 2013
    ..diseases exhibiting periodicity or cyclicity which include Bipolar Disorder, Schizophrenia, Seasonal Affective Disorder, Klein-Levin Syndrome, Sleep Disorders, Binging, Epilepsy, Multiple Sclerosis, Jet-Lag and Headache...
  9. CASEIN KINASE I AND THE REGULATION OF CIRCADIAN RHYTHM
    Donald E Ayer; Fiscal Year: 2010
    ..Pharmacological manipulation of rhythms could mitigate stress from jet lag, shift work, and perhaps even seasonal affective disorder.
  10. Photoperiod affects retinal function
    Chad R Jackson; Fiscal Year: 2012
    ..2011). Also, it is well known that humans with seasonal affective disorder (SAD) display altered mood (i.e., depression) during extreme changes in lighting environment...
  11. Pharmaceutical Therapy for Seasonal Affective Disorder
    Jay K Trautman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Seasonal Affective Disorder (SAD) is one of the most common mood disorders, affecting 1-3% of the population in temperate climates, predominantly women...
  12. The melanopsin-driven pupillary light reflex in seasonal affective disorder
    Kathryn A Roecklein; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Seasonal affective disorder (SAD) is characterized by recurrent depressive episodes with a seasonal pattern, most often occurring in fall and winter...
  13. Neural Basis for SAD: Development of a Diurnal Rodent Model
    Lily Yan; Fiscal Year: 2013
    ..This is a revised application for two years support to study the neurobiological mechanisms underlying seasonal affective disorder (SAD)...
  14. Cognitive Behavioral Therapy Vs. Light Therapy for Preventing SAD Recurrence
    Kelly J Rohan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Seasonal affective disorder (SAD) is a subtype of recurrent depression involving major depressive episodes during the fall and/or winter months that remit in the spring...
  15. Regulation of a Pacemaker Neural Output in Drosophila Circadian Rhythms
    BRIDGET LEAR; Fiscal Year: 2009
    ..Defective circadian rhythms are associated with disease states including bipolar disorder and seasonal affective disorder. Moreover, circadian rhythms genes originally identified and characterized in Drosophila have been ..
  16. The role of the circadian clock in encoding seasonal variations in day length
    JULIE SUZANNE PENDERGAST; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE Many patients diagnosed with seasonal affective disorder (SAD) experience depressive episodes only during the fall and winter, and treatment with early morning ..
  17. STRUCTURE AND FUNCTION OF MAMMALIAN GANGLION CELLS
    David M Berson; Fiscal Year: 2012
    ..body's responses to daylight, these studies are relevant to such public health issues as jet lag, seasonal affective disorder, circadian disruption in the blind, and the negative consequences of shift work including impaired ..
  18. TREATMENT OF CIRCADIAN SLEEP DISORDERS WITH BRIGHT LIGHT
    Steven W Lockley; Fiscal Year: 2010
    ..treatment of delayed sleep phase disorder, advanced sleep phase disorder, shift-work sleep disorder, jet lag, seasonal affective disorder, "sundowning" in Alzheimer's Disease, and age-related sleep maintenance insomnia.
  19. An Integrated Chronobiological-Cognitive Approach to Seasonal Affective Disorder
    JENNIFER NICOLE MAHON; Fiscal Year: 2013
    ..from leading chronobiological and cognitive-behavioral SAD researchers to test an integrative model of seasonal affective disorder (SAD)...
  20. ipRGC participation and modulation of retinal wave activity
    JORDAN MICHAEL RENNA; Fiscal Year: 2012
    ..response to daylight and therefore, these studies are relevant to such public health issues as jet lag, seasonal affective disorder, circadian disruption in the blind, and the negative consequences of shift work including impaired ..
  21. Light Treatment for Winter-SAD: Prediction of Response by Immediate Improvement
    TEODOR POSTOLACHE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Seasonal affective disorder winter type (SAD) consists of episodes of major depression in winter with remission in spring and summer...
  22. INTEGRATING ENERGY STORAGE, HIPPOCAMPUS AND HORMONES
    JEFFREY LUCAS; Fiscal Year: 2002
    b>Seasonal Affective Disorder (SAD) is a seasonal pattern of clinical depression that also correlates with changes in appetite, weight regulation, hormone profiles, and social interactions...
  23. NEUROENDOCRINE/IMMUNE INTERACTIONS: ROLE OF MELATONIN
    STEVEN YELLON; Fiscal Year: 2002
    ....
  24. EXTRAOCULAR CIRCADIAN PHOTOTRANSDUCTION IN HUMANS
    Scott Campbell; Fiscal Year: 2001
    DESCRIPTION (applicant's abstract): Circadian rhythm sleep disorders and seasonal affective disorder affect a large number of individuals across a wide age range...
  25. MELATONIN-LIGHT INTERACTION ON CIRCADIAN ACTIVITY
    Margarita Dubocovich; Fiscal Year: 2003
    ....
  26. MOOD SLEEP & SEASONALITY--CHILDREN AND ADOLESCENTS
    WILLIAM SONIS; Fiscal Year: 1991
    ..develop operational definitions of mania, hypomania and hyperthymia; investigate the epidemiology of Seasonal Affective Disorder (SAD) in junior and senior high school students; develop ambulatory measures of circadian and infradian ..
  27. VARIABLE SPECTRUM LIGHT FIELD FOR THE TREATMENT OF SAD
    Neil Goldman; Fiscal Year: 2002
    DESCRIPTION: Sufferers of Seasonal Affective Disorder respond quickly to light therapy in the fall and winter. Their treatment is usually confined to the home because light boxes are stationary, and head-mounted devices limit visibility...
  28. Kisspeptin: A novel calendar cell mechanism mediating sesaonal reproduction?
    DEBORAH LUTTERSCHMIDT; Fiscal Year: 2009
    ..have been implicated in age-related changes in brain function as well as mental disease states such as seasonal affective disorder, depression, bipolar disorder, and Alzheimer's disease...
  29. NOVEL CIRCADIAN MUTANT OF DROSOPHILA
    Jeffrey Price; Fiscal Year: 2001
    ..of the human circadian clock will contribute to treatments for sleep disorders, jet lag, cancer, and Seasonal Affective Disorder (SAD)...
  30. Physical Activity in relation to Depressive Symptoms in Black U.S Adults
    Elisa Torres; Fiscal Year: 2007
    ..psychological, sociocultural and physical) and situational influence (environmental risk factors for seasonal affective disorder) on the relationship of PA with depressive symptoms, and 3) examining the effects of combined ..
  31. VARIABLE SPECTRUM LIGHT FIELD--TREATMENT OF SAD
    Neil Goldman; Fiscal Year: 1999
    Suffers of Seasonal Affective Disorder respond quickly to light therapy in the fall and winter. Their treatment is usually confined to the home since light boxes are stationary and head-mounted devices limit visibility...
  32. CIRCADIAN REGULATORY CIRCUITS IN DROSOPHILA
    Paul Hardin; Fiscal Year: 2003
    ..Clock dysfunction is related to several common mental disorders such as manic-depressive illness, seasonal affective disorder and insomnia...
  33. TWILIGHTS AND CIRCADIAN ENTRAINMENT
    Ziad Boulos; Fiscal Year: 2001
    ..Thus, a systematic account of twilight-induced effects on circadian entrainment may provide the basis for refined clinical treatments of sleep phase and seasonal affective disorder.
  34. Roles of casein kinase le/d and b-Trcp in the mammalian circadian clock
    Choogon Lee; Fiscal Year: 2010
    ..will also provide a better framework for the development of treatments to combat human disorders associated with clock malfunction such as manic depression, chronic sleep disorder and seasonal affective disorder.
  35. Sleep Disturbance in Marijuana Withdrawal
    Karen Bolla; Fiscal Year: 2004
    ..of insomnia, could be treated with light therapy, the same treatment used successfully for treating seasonal affective disorder. New treatments for alleviating the unpleasant symptoms of marijuana withdrawal would likely increase ..
  36. Circadian Oscillators in Cultured Mammalian Tissue
    Michael Menaker; Fiscal Year: 2006
    ..performance deficits produced by shift work, insomnia and pathologies with circadian components such as seasonal affective disorder (SAD). Furthermore, it is basic to the design of treatments for many serious conditions (e.g...
  37. Blue LED Light Panel For Treatment of Winter Depression
    HENRY SAVAGE; Fiscal Year: 2002
    ..have established that bright light therapy is effective in alleviating symptoms of winter depression (seasonal affective disorder, or SAD)...
  38. EXTRAOCULAR LIGHT TREATMENT
    HENRY SAVAGE; Fiscal Year: 2000
    b>Seasonal Affective Disorder (SAD, winter depression) is a relatively common form of depression...
  39. Melanopsin polymorphisms in seasonal affective disorder
    KATHRYN ROECKLEIN; Fiscal Year: 2006
    ....
  40. Genetic Analysis of Circadian Oscillator Hierarchy
    David Weaver; Fiscal Year: 2006
    ..workers and during jet lag, and may contribute to neuropsychiatric disorders including depression and seasonal affective disorder. A transcriptional-translational feedback loop is at the center of the circadian clock mechanism...
  41. Piperidine Derivatives as Radiotracers for Serotonin Transporters
    Gilles Tamagnan; Fiscal Year: 2004
    ..a role in several physiological and pathophysiological processes, especially in depression, anxiety, seasonal affective disorder, bulimia, and psychosis, as demonstrated by post-mortem and preliminary imaging studies...
  42. In vivo evaluation of a new ligand with picomolar affinity for the serotonin tran
    Gilles Tamagnan; Fiscal Year: 2009
    ..critical role in several physiological and pathophysiological processes, including depression, anxiety, seasonal affective disorder, bulimia, and psychosis, as demonstrated by post-mortem data, clinical efficacy of therapies affecting ..
  43. CIRCANNUAL RHYTHMS, BEHAVIOR AND REPRODUCTION
    Irving Zucker; Fiscal Year: 2000
    ..This research may provide insight into the proximate neural bases for human rhythms and aid in the development of hormone and light therapies for treatment of seasonal affective disorders and other seasonal disturbances. ..
  44. Identification of the circadian clock proteome
    Jason DeBruyne; Fiscal Year: 2005
    ..g. jet lag, shift work) and more serious conditions such as circadian rhythm sleep disorders and other clock-related psychological disorders (e.g. seasonal affective disorder).
  45. Intrinsic photosensitivity of retinal ganglion cells
    MICHAEL TRI DO; Fiscal Year: 2007
    ..terms of visual perception, but its widespread importance to physiology is evident in ailments such as seasonal affective disorder and jet lag, where it plays the major role...
  46. TRANSGENIC MOUSE REPORTERS OF CIRCADIAN GENE EXPRESSION
    Douglas McMahon; Fiscal Year: 2001
    ..future research on the molecular basis of the mammalian SCN clock which should increase our understanding of the mechanism of seasonal affective disorder, age-related disruption of biological timing, and jet lag.
  47. The role of clock protein phosphorylation and degradation in circadian biology
    JOANNA CHIU; Fiscal Year: 2009
    ....
  48. Cognitive-Behavioral Approaches to Seasonal Depression
    KELLY ROHAN; Fiscal Year: 2003
    b>Seasonal affective disorder (SAD), a recurrent fall-winter depression with periods of remission in spring and summer, is a highly prevalent mental health problem, especially at Northern latitudes...
  49. Melatonin Studies of Totaly Blind Children
    Alfred J Lewy; Fiscal Year: 2010
    ..In a future grant application, we will assess feasibility of a large-scale, multi-center study of melatonin safety and efficacy, which may also be of benefit sighted people with circadian rhythm sleep and mood disorders ..
  50. Melatonin Entrainment of Elderly Blind Free-runners
    Alfred Lewy; Fiscal Year: 2006
    ..The study of blind people provides an opportunity to understand the physiology of the circadian system in humans unperturbed by the light/dark cycle. ..
  51. LIGHTION THERAPY FOR SEASONAL AFFECTIVE DISOR
    Michael Terman; Fiscal Year: 2003
    Light therapy for winter depression (Seasonal Affective Disorder, SAD), offers the promise of major alleviation of symptoms of fatigue, hyperphagia, hypersomnia, dysphoria, and anxiety that - according to recent surveys - are experienced ..
  52. PHASE SHIFTING EFFECTS OF MELATONIN IN WINTER DEPRESSION
    Alfred Lewy; Fiscal Year: 2001
    ..The proposed study should further our understanding of light melatonin and biological rhythms in winter depression. ..
  53. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  54. Transcranial Magnetic Stimulation in the Treatment of Chronic Widespread Pain
    David Avery; Fiscal Year: 2008
    ..TMS is a technique that non-invasively affects the brain, including areas of the brain involved in pain perception. [unreadable] [unreadable] [unreadable]..
  55. Optimization of TMS for Depression
    David Avery; Fiscal Year: 2009
    ..This clinical site grant (CSG) proposal is one of four scientifically identical proposals resubmitted under a CSMD mechanism.] ..
  56. TMS TREATMENT OF MAJOR DEPRESSION
    David Avery; Fiscal Year: 2002
    ..Nonresponders to sham stimulation will be offered rTMS. ..
  57. PHASE RESPONSE CURVES FOR EXERCISE AND BRIGHT LIGHT
    DANIEL KRIPKE; Fiscal Year: 2002
    ..Resultant circadian phases will then be determined to compute the phase response curves, in order to examine interactions of stimulus (exercise vs. light), age, and gender on circadian responsiveness. ..
  58. VERIFICATION OF CIRCADIAN ABNORMALITIES IN AGING
    DANIEL KRIPKE; Fiscal Year: 2002
    ....
  59. NEURONAL DYSFUNCTION IN PREMENSTRUAL DYSPHORIC DISORDER
    C Epperson; Fiscal Year: 2004
    ..abstract_text> ..
  60. PRACTICAL CIRCADIAN INTERVENTIONS FOR NIGHT SHIFT WORK
    CHARMANE EASTMAN; Fiscal Year: 2007
    ..This work will have important implications for the health, safety, and well being of the night shift worker. [unreadable] [unreadable]..
  61. SSRI-INDUCED CHANGES IN CORTICAL GABA IN WOMEN WITH PMDD
    CYNTHIA EPPERSON; Fiscal Year: 2007
    ..We anticipate that our findings will provide further support for the role of GABA and neurosteroids in the pathogenesis and treatment of PMDD. ..