depressive disorder

Summary

Summary: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.

Top Publications

  1. ncbi Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
  2. ncbi The validity of the Hospital Anxiety and Depression Scale. An updated literature review
    Ingvar Bjelland
    Department of Public Health and Primary Health Care, Section for Preventive Medicine, Haukeland Hospital, Armauer Hansen Building, University of Bergen, N 5021, Bergen, Norway
    J Psychosom Res 52:69-77. 2002
  3. ncbi Depression, chronic diseases, and decrements in health: results from the World Health Surveys
    Saba Moussavi
    Department of Measurement and Health Information Systems, World Health Organization, Geneva, Switzerland
    Lancet 370:851-8. 2007
  4. ncbi Internet-based cognitive behaviour therapy for symptoms of depression and anxiety: a meta-analysis
    Viola Spek
    Department of Psychology and Health, Tilburg University, The Netherlands
    Psychol Med 37:319-28. 2007
  5. ncbi Collaborative care for depression: a cumulative meta-analysis and review of longer-term outcomes
    Simon Gilbody
    Department of Health Sciences, University of York, York, England
    Arch Intern Med 166:2314-21. 2006
  6. ncbi The prevalence of comorbid depression in adults with diabetes: a meta-analysis
    R J Anderson
    Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
    Diabetes Care 24:1069-78. 2001
  7. ncbi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
  8. ncbi Global burden of depressive disorders in the year 2000
    T B Ustun
    Global Programme on Evidence for Health Policy, WHO, Geneva, Switzerland
    Br J Psychiatry 184:386-92. 2004
  9. pmc Delivering interventions for depression by using the internet: randomised controlled trial
    Helen Christensen
    Centre for Mental Health Research, Australian National University, Canberra, ACT 0200, Australia
    BMJ 328:265. 2004
  10. ncbi Mediators and moderators of treatment effects in randomized clinical trials
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Calif 94305, USA
    Arch Gen Psychiatry 59:877-83. 2002

Detail Information

Publications296 found, 100 shown here

  1. ncbi Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
    ..This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup...
  2. ncbi The validity of the Hospital Anxiety and Depression Scale. An updated literature review
    Ingvar Bjelland
    Department of Public Health and Primary Health Care, Section for Preventive Medicine, Haukeland Hospital, Armauer Hansen Building, University of Bergen, N 5021, Bergen, Norway
    J Psychosom Res 52:69-77. 2002
    ..To review the literature of the validity of the Hospital Anxiety and Depression Scale (HADS)...
  3. ncbi Depression, chronic diseases, and decrements in health: results from the World Health Surveys
    Saba Moussavi
    Department of Measurement and Health Information Systems, World Health Organization, Geneva, Switzerland
    Lancet 370:851-8. 2007
    ..Depression is often comorbid with other chronic diseases and can worsen their associated health outcomes. Few studies have explored the effect of depression, alone or as a comorbidity, on overall health status...
  4. ncbi Internet-based cognitive behaviour therapy for symptoms of depression and anxiety: a meta-analysis
    Viola Spek
    Department of Psychology and Health, Tilburg University, The Netherlands
    Psychol Med 37:319-28. 2007
    ..We studied to what extent internet-based cognitive behaviour therapy (CBT) programs for symptoms of depression and anxiety are effective...
  5. ncbi Collaborative care for depression: a cumulative meta-analysis and review of longer-term outcomes
    Simon Gilbody
    Department of Health Sciences, University of York, York, England
    Arch Intern Med 166:2314-21. 2006
    ....
  6. ncbi The prevalence of comorbid depression in adults with diabetes: a meta-analysis
    R J Anderson
    Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
    Diabetes Care 24:1069-78. 2001
    ..CONCLUSIONS--The presence of diabetes doubles the odds of comorbid depression. Prevalence estimates are affected by several clinical and methodological variables that do not affect the stability of the ORs...
  7. ncbi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
    ..To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples...
  8. ncbi Global burden of depressive disorders in the year 2000
    T B Ustun
    Global Programme on Evidence for Health Policy, WHO, Geneva, Switzerland
    Br J Psychiatry 184:386-92. 2004
    ..The initial Global Burden of Disease study found that depression was the fourth leading cause of disease burden, accounting for 3.7% of total disability adjusted life years (DALYs) in the world in 1990...
  9. pmc Delivering interventions for depression by using the internet: randomised controlled trial
    Helen Christensen
    Centre for Mental Health Research, Australian National University, Canberra, ACT 0200, Australia
    BMJ 328:265. 2004
    ....
  10. ncbi Mediators and moderators of treatment effects in randomized clinical trials
    Helena Chmura Kraemer
    Department of Psychiatry and Behavioral Sciences, Stanford University, Calif 94305, USA
    Arch Gen Psychiatry 59:877-83. 2002
    ..We recommend that RCTs routinely include and report such analyses...
  11. pmc Effectiveness of a novel integrative online treatment for depression (Deprexis): randomized controlled trial
    Björn Meyer
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistr 52, Building O59, 20246 Hamburg, Germany
    J Med Internet Res 11:e15. 2009
    ..We developed the integrative, Web-based program Deprexis, which covers therapeutic approaches such as behavioral activation, cognitive restructuring, mindfulness/acceptance exercises, and social skills training...
  12. ncbi Genetic epidemiology of major depression: review and meta-analysis
    P F Sullivan
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Am J Psychiatry 157:1552-62. 2000
    ..The authors conducted a meta-analysis of relevant data from primary studies of the genetic epidemiology of major depression...
  13. pmc Internet-based treatment for adults with depressive symptoms: randomized controlled trial
    Lisanne Warmerdam
    Dept Clinical Psychology, VU University Amsterdam, FPP, Amsterdam, The Netherlands
    J Med Internet Res 10:e44. 2008
    ..Depression can be treated effectively with Internet-based cognitive behavioral therapy (CBT), but a short intervention based on problem solving therapy (PST) could constitute a worthwhile alternative to CBT...
  14. ncbi Treating depression in primary care in low-income women in Santiago, Chile: a randomised controlled trial
    Ricardo Araya
    Division of Psychiatry, University of Bristol, Bristol, UK
    Lancet 361:995-1000. 2003
    ..We aimed to compare the effectiveness of a stepped-care programme with usual care in primary-care management of depression in low-income women in Santiago, Chile...
  15. ncbi Effectiveness of an intervention led by lay health counsellors for depressive and anxiety disorders in primary care in Goa, India (MANAS): a cluster randomised controlled trial
    Vikram Patel
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 376:2086-95. 2010
    ..The MANAS trial aimed to test the effectiveness of an intervention led by lay health counsellors in primary care settings to improve outcomes of people with these disorders...
  16. ncbi Systematic review of depression, anxiety, and other indicators of psychological distress among U.S. and Canadian medical students
    Liselotte N Dyrbye
    Mayo Clinic, 200 First Street SW, Rochester, MN 55906, USA
    Acad Med 81:354-73. 2006
    ..To systematically review articles reporting on depression, anxiety, and burnout among U.S. and Canadian medical students...
  17. ncbi Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis
    Jurgen Barth
    Department of Rehabilitation Psychology, Institute of Psychology, University of Freiburg, Germany
    Psychosom Med 66:802-13. 2004
    ..The relative risk in meta-analytic aggregation is 1.64 (confidence interval [CI], 1.29-2.08) for any CHD event. However, the adverse impact of depression on CHD patients has not yet been the subject of a meta-analysis...
  18. pmc Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration
    Irving Kirsch
    Department of Psychology, University of Hull, Hull, United Kingdom
    PLoS Med 5:e45. 2008
    ..The purpose of this analysis is to establish the relation of baseline severity and antidepressant efficacy using a relevant dataset of published and unpublished clinical trials...
  19. ncbi Internet-based and other computerized psychological treatments for adult depression: a meta-analysis
    Gerhard Andersson
    Department of Behavioural Sciences and Learning, Swedish Institute for Disability Research, Linkoping University, Linkoping, Sweden
    Cogn Behav Ther 38:196-205. 2009
    ..45-0.77) and unsupported (d = 0.25; 95% CI: 0.14-0.35) treatments. The authors conclude that although more studies are needed, Internet and other computerized treatments hold promise as potentially evidence-based treatments of depression...
  20. ncbi Depression and pain comorbidity: a literature review
    Matthew J Bair
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Arch Intern Med 163:2433-45. 2003
    ..A model that incorporates assessment and treatment of depression and pain simultaneously is necessary for improved outcomes...
  21. ncbi Depressive symptoms and chronic obstructive pulmonary disease: effect on mortality, hospital readmission, symptom burden, functional status, and quality of life
    Tze Pin Ng
    Gerontological Research Programme, Faculty of Medicine, National University of Singapore, Singapore
    Arch Intern Med 167:60-7. 2007
    ..We evaluated the impact of comorbid depression on mortality, hospital readmission, smoking behavior, respiratory symptom burden, and physical and social functioning in patients with COPD...
  22. pmc Intrusive images in psychological disorders: characteristics, neural mechanisms, and treatment implications
    Chris R Brewin
    Research Department of Clinical, Educational and Health Psychology, University College London, Gower Street, London WC1E6BT, England
    Psychol Rev 117:210-32. 2010
    ..Finally, we discuss the treatment implications of the new model and relate it to existing forms of psychological therapy...
  23. ncbi Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial
    Jurgen Unutzer
    Center for Health Services Research, UCLA Neuropsychiatric Institute, 10920 Wilshire Blvd, Suite 300, Los Angeles, CA 90024, USA
    JAMA 288:2836-45. 2002
    ..Few depressed older adults receive effective treatment in primary care settings...
  24. ncbi The economic burden of depression in the United States: how did it change between 1990 and 2000?
    Paul E Greenberg
    Analysis Group, Inc, Boston, MA 02199, USA
    J Clin Psychiatry 64:1465-75. 2003
    ..9 billion dollars using revised prevalence data and a refined workplace cost estimation approach. The objective of the current report is to provide a 10-year update of these estimates using the same methodological framework...
  25. ncbi Hippocampal volume and depression: a meta-analysis of MRI studies
    Poul Videbech
    Institute for Basic Psychiatric Research, Department of Biological Psychiatry, Psychiatric Hospital, Aarhus University Hospital, DK 8240 Risskov, Denmark
    Am J Psychiatry 161:1957-66. 2004
    ..The authors performed a systematic review and meta-analysis of volumetric studies of the hippocampus in patients with mood disorders...
  26. pmc Cognitive behaviour therapy-based intervention by community health workers for mothers with depression and their infants in rural Pakistan: a cluster-randomised controlled trial
    Atif Rahman
    School of Population, Community, and Behavioural Sciences, University of Liverpool, Liverpool, UK
    Lancet 372:902-9. 2008
    ..We integrated a cognitive behaviour therapy-based intervention into the routine work of community-based primary health workers in rural Pakistan and assessed the effect of this intervention on maternal depression and infant outcomes...
  27. ncbi Prevalence of depression during pregnancy: systematic review
    Heather A Bennett
    Faculty of Pharmacy and Department of Medicine, University of Toronto, Ontario, Canada
    Obstet Gynecol 103:698-709. 2004
    ....
  28. ncbi New approaches to antidepressant drug discovery: beyond monoamines
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Rev Neurosci 7:137-51. 2006
    ..This review summarizes the obstacles that have hindered the development of non-monoamine-based antidepressants, and provides a progress report on some of the most promising current strategies...
  29. ncbi Measuring depression outcome with a brief self-report instrument: sensitivity to change of the Patient Health Questionnaire (PHQ-9)
    Bernd Löwe
    Department of General Internal and Psychosomatic Medicine, University of Heidelberg, Medical Hospital, Germany
    J Affect Disord 81:61-6. 2004
    ..Therefore, we investigated the sensitivity to change of the PHQ-9 in three groups of patients whose depression status either improved, remained unchanged, or deteriorated over time...
  30. ncbi Clinical diagnosis of depression in primary care: a meta-analysis
    Alex J Mitchell
    Leicestershire Partnership Trust, Leicester General Hospital, Leicester, UK
    Lancet 374:609-19. 2009
    ..Most care for depression is delivered by general practitioners (GPs). We assessed the rate of true positives and negatives, and false positives and negatives in primary care when GPs make routine diagnoses of depression...
  31. ncbi Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness
    H S Mayberg
    Research Imaging Center, University of Texas Health Science Center at San Antonio, USA
    Am J Psychiatry 156:675-82. 1999
    ..Expanding on this theory, this study examined functional interactions between specific limbic and neocortical regions accompanying normal and disease-associated shifts in negative mood state...
  32. ncbi Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis
    Joost P van Melle
    Department of Cardiology, Thoraxcenter, University Hospital Groningen, P O Box 30 001, 9700 RB, The Netherlands
    Psychosom Med 66:814-22. 2004
    ..To assess the association of depression following myocardial infarction (MI) and cardiovascular prognosis...
  33. pmc Prevalence of depression in survivors of acute myocardial infarction
    Brett D Thombs
    Johns Hopkins University Evidence Based Practice Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gen Intern Med 21:30-8. 2006
    ..To assess the prevalence and persistence of depression in patients with acute myocardial infarction (AMI) and the relationship between assessment modality and prevalence...
  34. ncbi Preventing the onset of depressive disorders: a meta-analytic review of psychological interventions
    Pim Cuijpers
    Department of Clinical Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081BT Amsterdam, The Netherlands
    Am J Psychiatry 165:1272-80. 2008
    ..A growing number of studies have tested the efficacy of preventive interventions in reducing the incidence of depressive disorders. Until now, no meta-analysis has integrated the results of these studies...
  35. ncbi Development of depression from preadolescence to young adulthood: emerging gender differences in a 10-year longitudinal study
    B L Hankin
    Department of Psychology, University of Wisconsin, Madison 53706, USA
    J Abnorm Psychol 107:128-40. 1998
    ....
  36. ncbi Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability?
    Odette L J Peerbooms
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, European Graduate School of Neuroscience, South Limburg Mental Health Research and Teaching Network, Maastricht University, Maastricht, The Netherlands
    Brain Behav Immun 25:1530-43. 2011
    ..and the major psychiatric disorders (i) schizophrenia (SZ), (ii) bipolar disorder (BPD), and (iii) unipolar depressive disorder (UDD)...
  37. ncbi Risk factors for depression among elderly community subjects: a systematic review and meta-analysis
    Martin G Cole
    Department of Psychiatry, St Mary s Hospital and McGill University, Quebeck, Canada
    Am J Psychiatry 160:1147-56. 2003
    ..The goal of this study was to determine risk factors for depression among elderly community subjects...
  38. doi Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on
    Judith H Lichtman
    Circulation 118:1768-75. 2008
    ..This multispecialty consensus document reviews the evidence linking depression with CHD and provides recommendations for healthcare providers for the assessment, referral, and treatment of depression...
  39. ncbi Sleep disturbances in depressed pregnant women and their newborns
    Tiffany Field
    Touch Research Institutes, University of Miami School of Medicine, United States
    Infant Behav Dev 30:127-33. 2007
    ..The newborns of the depressed mothers also had more sleep disturbances including less time in deep sleep and more time in indeterminate (disorganized) sleep, and they were more active and cried/fussed more...
  40. ncbi Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial
    Lisa F Berkman
    Harvard University, Boston, MA, USA
    JAMA 289:3106-16. 2003
    ..Depression and low perceived social support (LPSS) after myocardial infarction (MI) are associated with higher morbidity and mortality, but little is known about whether this excess risk can be reduced through treatment...
  41. ncbi Depression in late life: review and commentary
    Dan G Blazer
    Department of Psychiatry and Behavioral Sciences and Center for the Study of Aging, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Gerontol A Biol Sci Med Sci 58:249-65. 2003
    ..Finally, I present evidence for the current therapies prescribed for depressed elders, ranging from medications to group therapy...
  42. ncbi Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study
    Amit Anand
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Biol Psychiatry 57:1079-88. 2005
    ..In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls...
  43. ncbi Cost of depression in Europe
    Patrik Sobocki
    Medical Management Centre, Department of Learning Informatics Management and Ethics, Karolinska Institutet, Stockholm, Sweden
    J Ment Health Policy Econ 9:87-98. 2006
    ..Yet, the knowledge of the economic impact of depression has been relatively little researched in Europe...
  44. pmc Course of illness, hippocampal function, and hippocampal volume in major depression
    Glenda M MacQueen
    Mood Disorders Program, Department of Radiology, McMaster University, Hamilton, ON, Canada L8N 3Z5
    Proc Natl Acad Sci U S A 100:1387-92. 2003
    ..Reductions in hippocampal volume may not antedate illness onset, but volume may decrease at the greatest rate in the early years after illness onset...
  45. ncbi Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
    P W Gold
    Clinical Neuroendocrinology Branch, Intramural Research Program, NIMH NIH, NIH Clinical Center, Room 2D 46 1284, Bethesda, MD 20892 1284, USA
    Mol Psychiatry 7:254-75. 2002
    ....
  46. ncbi The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
    C Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 49:1023-39. 2001
    ..The identification of the neurobiological substrates of early adverse experience is of paramount importance for the development of novel treatments for children, adolescents, and adults...
  47. ncbi Diagnosis and treatment of depression following routine screening in patients with coronary heart disease or diabetes: a database cohort study
    C Burton
    Centre for Population Health Sciences, University of Edinburgh, UK
    Psychol Med 43:529-37. 2013
    ..Depression is common in chronic illness and screening for depression has been widely recommended. There have been no large studies of screening for depression in routine care for patients with chronic illness...
  48. pmc Depression in adolescence
    Anita Thapar
    Child and Adolescent Psychiatry Section, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Wales, UK ac uk
    Lancet 379:1056-67. 2012
    Unipolar depressive disorder in adolescence is common worldwide but often unrecognised. The incidence, notably in girls, rises sharply after puberty and, by the end of adolescence, the 1 year prevalence rate exceeds 4%...
  49. ncbi Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Arch Gen Psychiatry 61:705-13. 2004
    ..An initial report, using this technique, suggested that occipital cortex GABA concentrations are reduced in patients with major depressive disorder (MDD) relative to healthy comparison subjects.
  50. ncbi Internet-based self-help for depression: randomised controlled trial
    Gerhard Andersson
    Department of Behavioural Sciences, Linkoping University, SE 581 83 Linkoping, Sweden
    Br J Psychiatry 187:456-61. 2005
    ..Many individuals with depression use the internet for discussion of symptoms and to share their experience...
  51. ncbi Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies
    Amanda Nicholson
    Department of Epidemiology and Public Health, University College London Medical School, 1 19 Torrington Place, London WC1E 6BT, UK
    Eur Heart J 27:2763-74. 2006
    ..We quantified the effect of depression on CHD, assessing the extent of confounding by coronary risk factors and disease severity...
  52. ncbi Hospital Anxiety and Depression (HAD) scale: factor structure, item analyses and internal consistency in a large population
    A Mykletun
    Faculty of Psychology, University of Bergen, Bergen, Norway
    Br J Psychiatry 179:540-4. 2001
    ....
  53. pmc Talking about depression: a qualitative study of barriers to managing depression in people with long term conditions in primary care
    Peter A Coventry
    Greater Manchester Collaboration for Leadership in Applied Health Research and Care, Health Sciences Research Group and Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK
    BMC Fam Pract 12:10. 2011
    ..The aim of this study was to identify and explore barriers to detecting and managing depression in primary care in people with two exemplar LTCs: diabetes and coronary heart disease (CHD)...
  54. ncbi Maternal depression and parenting behavior: a meta-analytic review
    M C Lovejoy
    Department of Psychology, Northern Illinois University, DeKalb 60115, USA
    Clin Psychol Rev 20:561-92. 2000
    ..interviews and self-report measures yielded similar effects, suggesting that deficits are not specific to depressive disorder. Research is needed to identify factors that affect the magnitude of parenting deficits among women who are ..
  55. ncbi Relationship of depression and diabetes self-care, medication adherence, and preventive care
    Elizabeth H B Lin
    Center for Health Studies, Group Health Cooperative, 1730 Minor Ave, Suite 1600, Seattle, WA 98101, USA
    Diabetes Care 27:2154-60. 2004
    ..We assessed whether diabetes self-care, medication adherence, and use of preventive services were associated with depressive illness...
  56. ncbi Impaired verbal memory in young adults with unipolar and bipolar depression
    Daniel F Hermens
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Camperdown, New South Wales, Australia
    Early Interv Psychiatry 4:227-33. 2010
    ..Specifically, deficits in verbal memory have been linked to depression in young people. This study examined whether young adults with unipolar compared with bipolar depression showed similar neurocognitive deficits...
  57. ncbi Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis of 25 years of research
    Anna Meijer
    Interdisciplinary Center for Psychiatric Epidemiology, University Medical Center Groningen University of Groningen, The Netherlands
    Gen Hosp Psychiatry 33:203-16. 2011
    ....
  58. ncbi Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort
    Almudena Sanchez-Villegas
    Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Spain
    Arch Gen Psychiatry 66:1090-8. 2009
    ..Adherence to the Mediterranean dietary pattern (MDP) is thought to reduce inflammatory, vascular, and metabolic processes that may be involved in the risk of clinical depression...
  59. ncbi Stress and depression among medical students: a cross-sectional study
    Marie Dahlin
    Department of Clinical Neuroscience, Section Psychiatry, St Göran, Stockholm, Sweden
    Med Educ 39:594-604. 2005
    ..To assess the exposure to different stressors and the prevalence of depression among medical students at different levels of education, taking gender differences into account...
  60. ncbi Collaborative care for depression in primary care. Making sense of a complex intervention: systematic review and meta-regression
    Peter Bower
    National Primary Care Research and Development Centre, University of Manchester, Manchester M13 9PL, UK
    Br J Psychiatry 189:484-93. 2006
    ..The management of depression in primary care is a significant issue for health services worldwide. "Collaborative care" interventions are effective, but little is known about which aspects of these complex interventions are essential...
  61. ncbi Perceived stigma as a predictor of treatment discontinuation in young and older outpatients with depression
    J A Sirey
    Outpatient Department, Westchester Division, New York Presbyterian Hospital, White Plains, NY, USA
    Am J Psychiatry 158:479-81. 2001
    ..The authors' goal was to examine the extent to which perceived stigma affected treatment discontinuation in young and older adults with major depression...
  62. ncbi Costs and consequences of enhanced primary care for depression: systematic review of randomised economic evaluations
    Simon Gilbody
    Department of Health Sciences, University of York, York YO10 6DD, UK
    Br J Psychiatry 189:297-308. 2006
    ..Decision-makers are likely to need to know whether these interventions are cost-effective in routine primary care settings...
  63. ncbi A meta-analysis of randomized trials of behavioural treatment of depression
    D Ekers
    Tees Esk and Wear Valleys NHS Trust University of York Department of Health Sciences, The Health Centre, Newcastle Road, Chester le Street, Co Durham, UK
    Psychol Med 38:611-23. 2008
    ..This systematic review sought to identify all randomized trials of behavioural therapy for depression, determine the effect of such interventions and examine any moderators of such effect...
  64. ncbi Excess mortality in depression: a meta-analysis of community studies
    Pim Cuijpers
    Netherlands Institute of Mental Health and Addiction, Trimbos Institute, PO Box 725, 3500 AS, Utrecht, The Netherlands
    J Affect Disord 72:227-36. 2002
    ..Furthermore, it has been hypothesized that mortality rates in depressed men are higher than in depressed women. Finally, it is not clear if the increased mortality rates exist only in major depression or also in subclinical depression...
  65. pmc Enhanced depression care for patients with acute coronary syndrome and persistent depressive symptoms: coronary psychosocial evaluation studies randomized controlled trial
    Karina W Davidson
    Department of Medicine, Columbia University College of Physicians and Surgeons, PH9 Center, 622 W 168th St, Room 948, New York, NY 10032, USA
    Arch Intern Med 170:600-8. 2010
    ..This study was conducted to determine the acceptability and efficacy of enhanced depression treatment in patients with ACS...
  66. ncbi Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals
    Greg J Siegle
    University of Pittsburgh Medical School and Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 51:693-707. 2002
    ..This study examined whether brain activity in response to emotional stimuli was sustained in depressed individuals, even following subsequent distracting stimuli...
  67. ncbi Paroxetine for the prevention of depression induced by high-dose interferon alfa
    D L Musselman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    N Engl J Med 344:961-6. 2001
    ..85). The incidence of adverse events was similar in the two groups. CONCLUSIONS: In patients with malignant melanoma, pretreatment with paroxetine appears to be an effective strategy for minimizing depression induced by interferon alfa...
  68. ncbi On the validity of the Beck Depression Inventory. A review
    P Richter
    Department of Psychiatry, University of Heidelberg, Germany
    Psychopathology 31:160-8. 1998
    ..Since most studies are oriented along the criteria of the classical test theory, our review will discuss to what extent the BDI meets these criteria...
  69. ncbi Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn
    Christina D Chambers
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA
    N Engl J Med 354:579-87. 2006
    ..We performed a case-control study to assess whether PPHN is associated with exposure to SSRIs during late pregnancy...
  70. ncbi Subthreshold depression in adolescence and mental health outcomes in adulthood
    David M Fergusson
    Christchurch Health and Development Study, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Arch Gen Psychiatry 62:66-72. 2005
    ..There is increasing interest in the extent to which individuals with subthreshold depression face increased risks of subsequent major depression and other disorders...
  71. ncbi Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data
    Craig J Whittington
    Centre for Outcomes Research and Effectiveness, Subdepartment of Clinical Health Psychology, University College London, 1 19 Torrington Place, London WC1E 7HB, UK
    Lancet 363:1341-5. 2004
    ..Questions concerning the safety of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression in children led us to compare and contrast published and unpublished data on the risks and benefits of these drugs...
  72. ncbi Internet-based cognitive behavioural therapy for subthreshold depression in people over 50 years old: a randomized controlled clinical trial
    Viola Spek
    Department of Psychology and Health, Tilburg University, The Netherlands
    Psychol Med 37:1797-806. 2007
    ....
  73. ncbi Gender differences in unipolar depression: an update of epidemiological findings and possible explanations
    C Kuehner
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Acta Psychiatr Scand 108:163-74. 2003
    ..To give an update on epidemiological findings on sex differences in the prevalence of unipolar depression and putative risk factors...
  74. ncbi What makes self-help interventions effective in the management of depressive symptoms? Meta-analysis and meta-regression
    Judith Gellatly
    Department of Nursing, Midwifery and Health Visiting, University of Manchester, UK
    Psychol Med 37:1217-28. 2007
    ..e. moderators of effect). This study sought to determine whether the content of self-help interventions, the study populations or aspects of study design were the most important moderators...
  75. ncbi The quality of care for depressive and anxiety disorders in the United States
    A S Young
    UCLA Neuropsychiatric Institute, Health Services Research Center, 10920 Wilshire Blvd, Suite 300, Los Angeles, CA 90024-6505, USA
    Arch Gen Psychiatry 58:55-61. 2001
    ..Most adults with a probable depressive or anxiety disorder do not receive appropriate care for their disorder. While this holds across diverse groups, appropriate care is less common in certain demographic subgroups...
  76. pmc Gliogenesis and glial pathology in depression
    G Rajkowska
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    CNS Neurol Disord Drug Targets 6:219-33. 2007
    ..Finally, we will consider the temporal relationship between glial and neuronal cell pathology in depression...
  77. ncbi An international study of the relation between somatic symptoms and depression
    G E Simon
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101 1448, USA
    N Engl J Med 341:1329-35. 1999
    ..Of the patients in the original sample, 5447 underwent a structured assessment of depressive and somatoform disorders...
  78. pmc Differential association of cognitive and somatic depressive symptoms with heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study
    Peter De Jonge
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    Psychosom Med 69:735-9. 2007
    ....
  79. ncbi Quality-of-life impairment in depressive and anxiety disorders
    Mark Hyman Rapaport
    Department of Psychiatry, Cedars Sinai Medical Center, Thalians Mental Health Center C 301, Los Angeles, CA 90048, USA
    Am J Psychiatry 162:1171-8. 2005
    ....
  80. ncbi Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder
    D Cotter
    Department of Psychological Medicine and Neuropathology, Institute of Psychiatry, DeCrespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 58:545-53. 2001
    ..In this investigation, we have simultaneously assessed glial cell density and neuronal density and size in the anterior cingulate cortex in schizophrenia, major depressive disorder, and bipolar disorder.
  81. ncbi Recurrence after recovery from major depressive disorder during 15 years of observational follow-up
    T I Mueller
    NIMH Collaborative Program on the Psychobiology of Depression Clinical Studies, Brown University School of Medicine, Providence, RI 02906, USA
    Am J Psychiatry 156:1000-6. 1999
    The recurrence of an affective disorder in people who initially recover from major depressive disorder was characterized by using the unique longitudinal prospective follow-up data from the National Institute of Mental Health ..
  82. ncbi Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries
    Helle Kieler
    Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, T2, SE 171 76 Stockholm, Sweden
    BMJ 344:d8012. 2012
    ..To assess whether maternal use of selective serotonin reuptake inhibitors (SSRIs) increases the risk of persistent pulmonary hypertension in the newborn, and whether such an effect might differ between specific SSRIs...
  83. ncbi Computerised cognitive-behavioural therapy for depression: systematic review
    Eva Kaltenthaler
    ScHARR, University of Sheffield, Regent Court, 30 Regent Street, Sheffield S1 4DA, UK
    Br J Psychiatry 193:181-4. 2008
    ..Computerised cognitive-behavioural therapy (CCBT) is used for treating depression and provides a potentially useful alternative to therapist cognitive-behavioural therapy (CBT)...
  84. ncbi Using chronic pain to predict depressive morbidity in the general population
    Maurice M Ohayon
    Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, 3430 W Bayshore Rd, Suite 102, Palo Alto, CA 94303, USA
    Arch Gen Psychiatry 60:39-47. 2003
    ..assesses the prevalence of chronic (>or= 6 months' duration) painful physical conditions (CPPCs) (joint/articular, limb, or back pain, headaches, or gastrointestinal diseases) and their relationship with major depressive disorder.
  85. ncbi Abnormal neural activities in first-episode, treatment-naïve, short-illness-duration, and treatment-response patients with major depressive disorder: a resting-state fMRI study
    Wen Bin Guo
    Mental Health Center, First Affiliated Hospital, Guangxi Medical University Nanning, Guangxi 530021, China
    J Affect Disord 135:326-31. 2011
    ..brain regions in patients with first-episode, treatment-naïve, short-illness-duration, and treatment-response depression in resting state to test the abnormality hypothesis of limbic-cortical networks in major depressive disorder (MDD).
  86. ncbi A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich 80804, Germany
    Arch Gen Psychiatry 66:966-75. 2009
    ..Genetic factors and clinical characteristics contribute to the failure of a favorable treatment outcome...
  87. ncbi The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine
    N Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, Munchen, Germany
    Mol Psychiatry 11:680-4. 2006
    ..Moreover, the fact that treatment with an anti-inflammatory drug showed beneficial effects on MD indicates that inflammation is related to the pathomechanism of the disorder, although the exact mechanisms remain to become elucidated...
  88. ncbi Prevalence and correlates of depressive symptoms in Chinese older adults: a population-based study
    Jing Yu
    Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    Int J Geriatr Psychiatry 27:305-12. 2012
    ..In the present study, the prevalence, the potential risk, and the protective factors of depression in the Chinese older population were investigated...
  89. ncbi National patterns in antidepressant medication treatment
    Mark Olfson
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Arch Gen Psychiatry 66:848-56. 2009
    ..Antidepressants have recently become the most commonly prescribed class of medications in the United States...
  90. pmc Columbia Classification Algorithm of Suicide Assessment (C-CASA): classification of suicidal events in the FDA's pediatric suicidal risk analysis of antidepressants
    Kelly Posner
    Division of Child and Adolescent Psychiatry, Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Psychiatry 164:1035-43. 2007
    ....
  91. ncbi Depression and cardiac mortality: results from a community-based longitudinal study
    B W Penninx
    Institute for Research in Extramural Medicine, Vrije University, Amsterdam, The Netherlands
    Arch Gen Psychiatry 58:221-7. 2001
    ..This study examined and compared the effect of depression on cardiac mortality in community-dwelling persons with and without cardiac disease...
  92. ncbi Risk for psychopathology in the children of depressed mothers: a developmental model for understanding mechanisms of transmission
    S H Goodman
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    Psychol Rev 106:458-90. 1999
    ..Relevant issues are discussed, and promising directions for future research are suggested...
  93. ncbi Genome-wide pharmacogenetics of antidepressant response in the GENDEP project
    Rudolf Uher
    Medical Research Council Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, SE5 8AF, London, United Kingdom
    Am J Psychiatry 167:555-64. 2010
    ..The authors performed a genome-wide association analysis of improvement of depression severity with two antidepressant drugs...
  94. ncbi The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs
    Y K Kim
    Department of Psychiatry, Korea University Ansan Hospital, College of Medicine, Korea
    Mol Psychiatry 7:1107-14. 2002
    ....
  95. ncbi Rates and risks for co-morbid depression in patients with Type 2 diabetes mellitus: results from a community-based study
    F Pouwer
    Diabetes Research Group, Department of Medical Psychology, Institute for Research in Extramural Medicine EMGO, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Diabetologia 46:892-8. 2003
    ..We studied the prevalence and risk factors of co-morbid depression in a community-based sample of older adults, comparing Type 2 diabetic patients with healthy control subjects...
  96. ncbi Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment
    Jennifer L Warner-Schmidt
    Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Hippocampus 16:239-49. 2006
    ....
  97. ncbi From depressive symptoms to depressive disorders: the relevance of thresholds
    José L Ayuso-Mateos
    Department of Psychiatry, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid and Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain
    Br J Psychiatry 196:365-71. 2010
    ..Nosological boundaries for depressive disorders as well as the prevalence and impact of 'subsyndromal' depression remain unclear...
  98. ncbi Meta-analysis of the relationship between HIV infection and risk for depressive disorders
    J A Ciesla
    Department of Psychology, State University of New York at Buffalo, 14260-4110, USA
    Am J Psychiatry 158:725-30. 2001
    ..the data from 10 studies that compared HIV-positive and HIV-negative individuals for rates of major depressive disorder (N=2,596) or dysthymic disorder (N=1,822)...
  99. ncbi Epidemiology of comorbid coronary artery disease and depression
    Bruce Rudisch
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 54:227-40. 2003
    ..otherwise specified, the term depression will be used to designate all depressive states, including major depressive disorder, minor depression, dysthymia, and other subsyndromal forms of depression...
  100. ncbi Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors
    Lisa M Monteggia
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Biol Psychiatry 61:187-97. 2007
    ....
  101. ncbi Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis
    Valentina Nanni
    King s College London, Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry Research Centre, UK
    Am J Psychiatry 169:141-51. 2012
    ..The authors conducted the first meta-analysis to examine the relationship between childhood maltreatment and these clinically relevant measures of depression...

Research Grants81

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ..LIBR) focusing on bridging the gap between immune dysfunction and neuroimaging abnormalities in major depressive disorder (MDD)...
  3. 5-HT transporter function: Interaction of hormones and antidepressants
    Alan Frazer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The vulnerability of some women to develop major depressive disorder (MDD) is associated with hormonal fluctuations...
  4. Functional Neuroimaging of Individual Differences in Affect and Motivation
    BRIAN JAMES MICKEY; Fiscal Year: 2013
    ..Research. The K23 project focuses on neurobiological vulnerability to major depressive disorder (MDD), a common, debilitating, recurrent brain illness, and a significant public health problem worldwide...
  5. Dietary Supplement Creatine for Adolescent Females with SSRI-Resistant Depression
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..Piloting a novel intervention for female adolescents with treatment-resistant major depressive disorder (MDD), while quantifying its engagement of a mechanistic target, supports specific strategies outlined in ..
  6. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce S McEwen; Fiscal Year: 2013
    ..alterations and anxiety that, if they persist after the stressor is terminated, can become an anxiety or depressive disorder. One salient response of the brain to stress can be seen in the form of structural plasticity that has been ..
  7. Reversing Corticosteroid-Induced Memory Impairment
    E Sherwood Brown; Fiscal Year: 2013
    ..These have important implications to patients with mood disorders, as a subset of people with major depressive disorder and bipolar disorder have elevated cortisol levels...
  8. Safety signal learning in Rhesus monkeys following early life stressChallenge Ar
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..For example, central to the clinical problem of PTSD, which has a ~90% comorbidity with major depressive disorder in patients who had early life stress, is the inability of these patients to inhibit their fear to stimuli ..
  9. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    Major depressive disorder (MOD) is the fourth leading cause of disease burden worldwide, and the incidence of MOD in women is twice that of men...
  10. Postpartum Depression: Role of Sleep &Genetic Risk in Postpartum Mood Disorders
    Katherine M Sharkey; Fiscal Year: 2013
    ..prospective longitudinal study of mood, sleep, and genetic risk in perinatal women with a history of major depressive disorder or bipolar disorder...
  11. Mechanisms of structural plasticity in stress-related disorders
    Scott J Russo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mood and anxiety disorders such as major depressive disorder (MDD) and post traumatic stress disorder (PTSD) cause overlapping behavioral symptoms marked by hyperarousal, social avoidance, anxiety, ..
  12. Depression, Adipocytokines and Metabolic Dysregulation in Black and White Women
    Susan A Everson Rose; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Important links between major depressive disorder/depressive symptoms and risk for cardiovascular disease (CVD) morbidity and mortality have been documented...
  13. Transcranial Magnetic Stimulation in Pregnant Women with Depressive Disorder
    Deborah Kim; Fiscal Year: 2013
    ..It is critical that rTMS, as a non-pharmacologic treatment, be evaluated for the treatment of major depressive disorder (MDD) during pregnancy...
  14. Identifying Biomarkers for Post-Partum Depression in African-American Women
    Patrick F Sullivan; Fiscal Year: 2013
    ..to progress for autism, bipolar disorder, and schizophrenia, discerning the biological basis of major depressive disorder (MDD) has been difficult...
  15. The Neurochemistry of Cognitive Therapy: Predicting Treatment Outcome with PET
    Jeffrey M Miller; Fiscal Year: 2013
    ..applicant): Psychiatrists lack markers that would allow them to select treatments for patients with major depressive disorder (MDD) based on the likelihood of response in individual patients...
  16. Adult Neurogenesis: Regulation By Sleep
    DENNIS J MCGINTY; Fiscal Year: 2013
    ..Insomnia, particularly sleep fragmentation, predicts subsequent major depressive disorder (MDD) and recurrence of MDD in remitted patients...
  17. Web-Based Program to Improve Antidepressant Medication Adherence
    Rebekah K Hersch; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Mood disorders, including major depressive disorder, dysthymia, and bipolar disorder, affect nearly 21 million Americans or 9.5% of the U.S. population age 18 years of age and older...
  18. Using a Biomarker Panel for Detecting Adolescent Depression
    John A Bilello; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Depression (major depressive disorder, MDD) is the most common mental health disorder in the United States among teens and adults...
  19. Effect of Major Depression and antidepressants on human neurogenesis
    Maura Boldrini; Fiscal Year: 2013
    ..Decreased neurogenesis is an emerging model for the etiology of major depressive disorder (MDD). Antidepressant treatment (ADT) increases neurogenesis in the DG of rodents...
  20. Hostility, PTSD and Physical Health Risk Factors
    Jean C Beckham; Fiscal Year: 2013
    ..of PTSD by comparing two groups of patients with PTSD including those with and without co-morbid major depressive disorder. The project goals are to examine: (1) the independent relationship between PTSD and biomarkers of ..
  21. Omega-3 Fatty Acids &Psychoeducational Psychotherapy for Childhood Depression
    Mary A Fristad; Fiscal Year: 2013
    ..Approximately 2 to 4% of children experience either major depressive disorder or dysthymic disorder and 5 to 10% of children and adolescents experience subsyndromal depressive symptoms (..
  22. POST-EXERCISE ION CHANNEL GENE EXPRESSION BIOMARKERS IN CFS
    Kathleen C Light; Fiscal Year: 2013
    ..using our post-exercise gene expression profiles, 2) CFS patients also differ from patients with major depressive disorder and patients with prostate cancer who have cancer-related fatigue;3) these profiles reliably differentiate ..
  23. The Role of HIF-1 in Neurogenic and Behavior Responses to Antidepressants.
    W TIMOTHY O'BRIEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Major Depressive Disorder (MDD) is a debilitating mood disorder associated with significant morbidity and mortality...
  24. Small Animal Model of HIV Neuropathogenesis in the HAART Era
    Pietro P Sanna; Fiscal Year: 2012
    ..prevalence of milder and chronic forms of HIV central nervous system (CNS) disease and HIV-associated major depressive disorder remains high...
  25. Examination of Reward Processing in the Treatment of Adolescent Major Depression
    Randy Patrick Auerbach; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The prevalence of major depressive disorder (MDD) increases 5-fold during adolescence, and by the age of 18, approximately 20% of youth will experience a depressive episode...
  26. The role of BNST CGRP in stress-enhanced anxiety behavior and HPA-axis function
    Kelly S Sink; Fiscal Year: 2013
    ..are at increased risk for a number of psychiatric illnesses including post-traumatic stress disorder, major depressive disorder, and generalized anxiety disorder...
  27. 5-HT transporter function: Interaction of antidepressants and hormones
    Alan Frazer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The vulnerability of some women to develop major depressive disorder (MDD), which occurs more frequently in women than in men, is associated with hormonal fluctuations (monthly, pregnancy, postpartum,..
  28. Placebo Effects in the Treatment of Depression: Cognitive and Neural Mechanisms
    Bret R Rutherford; Fiscal Year: 2013
    ..to become an expert in the cognitive and neural mechanisms of placebo effects in the treatment of Major Depressive Disorder (MDD)...
  29. Functional Anatomy of REM Sleep: Brainstem-Control
    Gerald A Marks; Fiscal Year: 2013
    ..has been hypothesized to be centrally involved in post traumatic stress disorder as well as major depressive disorder . Selective deprivation of REM sleep results in a significant improvement of symptoms in depression...
  30. Hippocampal plasticity in co-morbid diabetes and depression
    LAWRENCE P contact REAGAN; Fiscal Year: 2010
    ..diabetes and depression Epidemiological and clinical studies determined that the incidence of major depressive disorder is greater than two fold higher in diabetic patients when compared with non-diabetic patients...
  31. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Paul Everall; Fiscal Year: 2010
    Major depressive disorder (MDD) is an etiologically and phenotypically complex disorder causing significant morbidity and mortality...
  32. GENE EXPRESSION EXON ARRAY BIOMARKERS TO DIAGNOSE SCHIZOPHRENIA
    Terry W Osborn; Fiscal Year: 2010
    ..means of genetically diagnosing and differentiating schizophrenia (SZ), bipolar disorder (BD) and Major Depressive Disorder (MDD) from normal/healthy individuals (NC) with mRNA gene expression signatures from a blood sample...
  33. Neuroimmune Factors and Co-Morbid Fear, Depression and Alcohol Consumption
    Michael S Fanselow; Fiscal Year: 2010
    ..Increases in levels of pro-inflammatory cytokines are observed in PTSD, and major depressive disorder (MDD). Microglia as well as pro-inflammatory cytokines are increased in the brains of alcoholics...
  34. Predictors of Treatment Response Relapse and Recurrence in Major Depression
    W Edward Craighead; Fiscal Year: 2012
    ..Major Depressive Disorder has a lifetime occurrence rate of 16% and is among the most frequent and debilitating of all medical ..
  35. Trophic factors and regulation of hippocampal neuroplasticity in the human brain
    Maura Boldrini; Fiscal Year: 2012
    ..Decreased neurogenesis is hypothesized in major depressive disorder (MDD)...
  36. Identification and Validation of Human Hypothalamic Nuclei in-vivo and ex-vivo Us
    Nikolaos Makris; Fiscal Year: 2010
    ..In fact, the paraventricular hypothalamic nucleus (PVN) is enlarged in patients with major depressive disorder (MDD), in PVN neurons that are dense in corticotropin releasing hormone (CRH) and estrogen receptor (ER)1...
  37. A Comprehensive Intervention for Diabetes and Comorbid Depression in Primary Care
    Madhukar H Trivedi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The prevalence of major depressive disorder (MDD) among patients with diabetes (DM) is twice that of the general population...
  38. Optimizing Treatment of Mental Illness during Pregnancy:Improving Infant Outcomes
    Katherine L Wisner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The period prevalence of major depressive disorder (MDD) was 12.7% during pregnancy and a striking 14.5% women experience postpartum depression...
  39. BDNF-Trk Signaling &Cytokines in Patients with Mood Disorders
    Ghanshyam N Pandey; Fiscal Year: 2013
    ..platelets, lymphocytes, neutrophils, and plasma from 40 well-characterized drug-free patients with major depressive disorder (MDD), 40 bipolar manic or mixed (BPM), 40 normal control subjects and from 19 bipolar depressed (BPD) ..
  40. NORADRENERGIC SYSTEM IN DEPRESSION
    GREGORY ALLEN ORDWAY; Fiscal Year: 2012
    ..implicate brain noradrenergic overactivity and norepinephrine (NE) depletion in the neuropathology of major depressive disorder (MDD)...
  41. Neural mechanisms underlying abnormal food reward processing in depressed women
    LAURA MCGRATH HOLSEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The comorbidity between major depressive disorder (MDD) and obesity appears especially strong in and perhaps limited to females, even controlling for demographic variables, as evidenced by ..
  42. FETAL AND NEONATAL NEUROBEHAVIOR AND PRENATAL ANTIDEPRESSANT EXPOSURE: THE CHILD
    Amy L Salisbury; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Over 400,000 pregnant women and their fetuses experience Major Depressive Disorder (MDD) every year in the United States...
  43. Specificity and Validity of Oxidative Stress Model of Chronic Fatigue Syndrome
    Dikoma C Shungu; Fiscal Year: 2013
    ..that can differentiate the disorder from phenotypically similar psychiatric conditions, such as major depressive disorder (MDD), could thus have a profound impact, not only for how the disorder is generally perceived and managed, ..
  44. Calcium Sensing Proteins in Depression
    Yogesh Dwivedi; Fiscal Year: 2013
    ..by applicant): Altered synaptic and structural plasticity play a crucial role in the pathogenesis of major depressive disorder (MDD);however, the precise molecular and cellular nature of events that lead to such altered plasticity ..
  45. Novel transgenic tools for analysis of 5HT2C receptor expression and function
    Ronald B Emeson; Fiscal Year: 2013
    ..5HT2C) has been implicated in a number of human psychiatric and behavioral disorders, including major depressive disorder, dysthymia, obsessive-compulsive disease, anxiety, and schizophrenia...
  46. The Antidepressant Action of Ketamine:Brain Chemistry
    MATE ISTVAN MILAK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Major depressive disorder (MDD) is a highly prevalent illness, affecting over 14 million American adults annually...
  47. Bupropion for Depression in ESRD Patients on Hemodialysis
    Pedro L Delgado; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Depressive symptoms, major depressive disorder (MDD), and cognitive impairment are among the most frequent behavioral problems reported in patients with ESRD receiving maintenance hemodialysis (HD)...
  48. Calcium-Stimulated Adenylyl Cyclase Activity's Role in Stress-Facilitated Memory
    LINDSAY ANN WIECZOREK; Fiscal Year: 2010
    ..Two stress- and memory-associated disorders, posttraumatic stress disorder and major depressive disorder, are prime examples of disorders with abnormal stress-facilitated memory processing, and they both have an ..
  49. Prevalence and Correlates of Minor Depression in Type 2 Diabetes
    Sherita Hill Golden; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Major depressive disorder (MDD) is cross-sectionally and longitudinally associated with risk of type 2 diabetes (T2DM), as well as with an increased risk of micro- and macrovascular complications, ..
  50. Novel Mechanisms Underlying Depression: PET Imaging of the Kappa Opioid Receptor
    Jeffrey M Miller; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Our understanding of the pathophysiology underlying major depressive disorder (MDD) is incomplete...
  51. HPA Stress Reactivity &Genetic Influences in Postpartum Depression
    SAMANTHA ERIKA MELTZER-BRODY; Fiscal Year: 2013
    ..PPD may be a more homogeneous subset of major depressive disorder (MDD) suggested by its linkage to a puerperal endocrine trigger that is more amenable to searches for ..
  52. The Role of cAMP/PKA Signaling in Neural Circuits Underlying Memory Formation
    Seth M Tomchik; Fiscal Year: 2013
    ..also appears to be involved in some mental illnesses, as it has been implicated in bipolar disorder, major depressive disorder, and schizophrenia...
  53. Attenuation of Corticosteroid-Induced Hippocampal Changes
    E Sherwood Brown; Fiscal Year: 2013
    ..findings have important implications for patients with mood disorders, as a subset of people with major depressive disorder and bipolar disorder show evidence of HPA axis activation and elevated cortisol...
  54. The Role of cAMP/PKA Signaling in Neural Circuits Underlying Memory Formation
    Seth M Tomchik; Fiscal Year: 2012
    ..also appears to be involved in some mental illnesses, as it has been implicated in bipolar disorder, major depressive disorder, and schizophrenia...
  55. Serotonin 1B Receptor Imaging in Major Depressive Disorder
    Alexander Neumeister; Fiscal Year: 2010
    ..by applicant): The serotonin type 1B (5-HT1B) receptor has been implicated in the pathogenesis of major depressive disorder (MDD). Highest concentrations of 5-HT1B receptors are found in the globus pallidus in humans...
  56. 3/3-Incomplete Response in Late-Life Depression: Getting to Remission
    Benoit H Mulsant; Fiscal Year: 2013
    ..We propose to enroll 500 patients aged 60 and older with major depressive disorder at the three sites and treat them openly for 12 weeks with venlafaxine XR (up to 225 mg/d) (phase 1)...
  57. Control of Dendritic and Synaptic Development by Extracellular Cues
    GARY ALLEN WAYMAN; Fiscal Year: 2013
    DESCRIPTION (PROVIDED BY APPLICANT): Major Depressive Disorder (MDD) is a recurrent mental illness that afflicts approximately 1 in 6 Americans at least once during their lifetime...
  58. An Investigation of the Clinical Utility of a Prolonged Grief Disorder Diagnosis
    Holly Gwen Prigerson; Fiscal Year: 2013
    ..virtual standardized patient (VSP) cases with and without PGD (both with and without co-morbid major depressive disorder [MDD] and posttraumatic stress disorder [PTSD];4 cases of spousal loss and 4 cases of child loss) using key ..
  59. 2/2 - Familial Pathways to Early-Onset Suicide Attempts
    JOSEPH JOHN MANN; Fiscal Year: 2013
    ..The cohort consists of 308 offspring of 135 probands with major depressive disorder (MDD) and a history of suicide attempt and a comparison group of 232 offspring of 120 non-attempters ..
  60. Assessing change in short-term therapy for depression using ESM
    Kari M Eddington; Fiscal Year: 2011
    ..Thirty-four adults with primary major depressive disorder will be randomly assigned to 16 weeks of either self-system therapy (SST), a new short-term, empirically-..
  61. A Cognitive Neuroscience Framework for Understanding and Treating Mood Disorders
    Moshe Bar; Fiscal Year: 2012
    ..Among mood disorders, major depressive disorder is a leading cause of disability, affecting annually more than 15 million people, with an estimated ..
  62. Cortical GABA in MDD and Primary Insomnia with Magnetic Resonance Spectroscopy
    John W Winkelman; Fiscal Year: 2013
    ..To investigate GABA levels in anterior cingulate cortex (ACC) and occipital cortex (OC) in major depressive disorder (MDD) and primary insomnia with proton magnetic resonance spectroscopy imaging (1H- MRS)...
  63. Development of a Model to Examine Corticosteroid Effects on the Hippocampus
    E Sherwood Brown; Fiscal Year: 2009
    ..findings may have important implications to patients with mood disorders, as a subset of people with major depressive disorder and bipolar disorder show evidence of HPA axis activation...
  64. Adapting Exercise Treatment for Depression to Adolescents: A Pilot Study
    PHILIPPE WEINTRAUB; Fiscal Year: 2010
    ..Major depressive disorder (MDD) in adolescence is common with point prevalence rates of 3% to 9%. In the U.S...
  65. Internet Self-Help Program for Major Depressive Disorder in Spouses of Combatants
    Bentson McFarland; Fiscal Year: 2009
    ..There is evidence to suggest that self-help programs on the Internet may be of value for people with major depressive disorder. However, effect sizes in previous research have usually been modest...
  66. Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar Disorder
    David Miklowitz; Fiscal Year: 2009
    ..with bipolar I or II disorder and meet criteria for BD not otherwise specified, cyclothymia, or major depressive disorder with hypomanic symptoms)...
  67. The effects of SAMe on reward circuitry in depression
    Diego Pizzagalli; Fiscal Year: 2007
    Major depressive disorder (MOD) is common, recurrent, and disabling. Despite a wide range of antidepressant treatments available, MOD remains difficult to treat...
  68. Using Information Technology to Provide Measurement Based Care for Chronic Illnes
    Madhukar Trivedi; Fiscal Year: 2009
    ..The proposal focuses on the use of MBC to improve the quality of care for patients with major depressive disorder (MDD)...
  69. COGNITIVE THERAPY FOR HIGH RISK & REFRACTORY DEPRESSION
    Robin Jarrett; Fiscal Year: 2003
    ..during the first eight months following response to acute phase CT in outpatients with recurrent major depressive disorder (MDD)...
  70. Processing of emotional content and brain activation in adolescents treated with
    GIOVANNI TIRADO SANTIAGO; Fiscal Year: 2010
    ..behavioral therapy (CBT) and fluoxetine treatment in adolescents with a positive diagnosis for major depressive disorder (MDD), and b) brain structure and metabolic activity related to the processing of emotional information...
  71. Information Technology Enabled Treatment of Adolescent Depression
    Steven Locke; Fiscal Year: 2009
    ..for this system innovation arises from the substantial costs that inadequately treated adolescent Major Depressive Disorder (MDD) has on the course of adolescent development and society as a whole...
  72. COGNITION, STEROIDS AND IMAGING IN CUSHINGS DISEASE
    MONICA STARKMAN; Fiscal Year: 2001
    ..significant proportion of the aged and in neuropsychiatric conditions such as Alzheimer's Disease and Major Depressive Disorder. However, the relationship of this dysregulation to clinical symptoms is still insufficiently understood...
  73. Biomarkers for Outcomes In Late-life Depression (BOLD)
    Ian A Cook; Fiscal Year: 2010
    ..Major depressive disorder (MDD) is a common psychiatric illness with high cost to society and individual patients...
  74. Does EPA or DHA prevent depressive symptoms in pregnancy and postpartum?
    Ellen Mozurkewich; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Major depressive disorder (MDD) during pregnancy and postpartum depression are associated with significant maternal and neonatal morbidity...
  75. HIV and Perinatal Depression in Brazil
    JUDITH KAREN BASS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Given the high global co-morbidity of HIV and major depressive disorder (MDD), understanding the negative synergistic effects of these two disabling conditions is increasingly important as ..
  76. CONTINUATION ECT VS PHARMACOTHERAPY--EFFICACY AND SAFETY
    Teresa Rummans; Fiscal Year: 2001
    ..DESCRIPTION (Applicant's abstract): Electroconvulsive therapy (ECT) is a highly effective treatment for major depressive disorder (MDD), that is helpful for patients with the most severe forms of affective illness...
  77. Improving Hispanic Retention in Antidepressant Therapy
    Roberto Lewis Fernandez; Fiscal Year: 2003
    ..outpatient pharmacological practice by a psychiatrist that will increase retention of Hispanics with major depressive disorder (MDD) in antidepressant therapy...
  78. Stress regulation of the endocannabinoid system: Effects on synaptic physiology
    Christian Reich; Fiscal Year: 2009
    Stress-related disorders such as major depressive disorder and post-traumatic-stress are serious mental illnesses that affect over 20 million Americans...