mood disorders

Summary

Summary: Those disorders that have a disturbance in mood as their predominant feature.

Top Publications

  1. ncbi Mood disorders in the medically ill: scientific review and recommendations
    Dwight L Evans
    School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Biol Psychiatry 58:175-89. 2005
  2. pmc Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
    Brain Struct Funct 213:93-118. 2008
  3. ncbi A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
  4. pmc Neurocircuitry of mood disorders
    Joseph L Price
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
    Neuropsychopharmacology 35:192-216. 2010
  5. pmc Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
    Int J Methods Psychiatr Res 21:169-84. 2012
  6. pmc Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders
    Gerard Sanacora
    Department of Psychiatry, Clinical Neuroscience Research Unit, Yale University School of Medicine, New Haven, CT, USA
    Neuropharmacology 62:63-77. 2012
  7. pmc Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Drug Discov 7:426-37. 2008
  8. pmc Circadian genes, rhythms and the biology of mood disorders
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Pharmacol Ther 114:222-32. 2007
  9. ncbi Effects of suppression and acceptance on emotional responses of individuals with anxiety and mood disorders
    Laura Campbell-Sills
    Department of Psychiatry 0985, University of California, San Diego, 8950 Villa La Jolla Drive, Suite C207, La Jolla, CA 92037, USA
    Behav Res Ther 44:1251-63. 2006
  10. ncbi Prevalence and incidence studies of mood disorders: a systematic review of the literature
    Paul Waraich
    Mental Health Evaluation and Community Consultation Unit, University of British Columbia, Vancouver
    Can J Psychiatry 49:124-38. 2004

Detail Information

Publications348 found, 100 shown here

  1. ncbi Mood disorders in the medically ill: scientific review and recommendations
    Dwight L Evans
    School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Biol Psychiatry 58:175-89. 2005
    The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected medical illnesses, review evidence for treatment, and determine needs in clinical ..
  2. pmc Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
    Brain Struct Funct 213:93-118. 2008
    ..that putatively modulate aspects of normal emotional behavior have been implicated in the pathophysiology of mood disorders by converging evidence from neuroimaging, neuropathological and lesion analysis studies...
  3. ncbi A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
    ....
  4. pmc Neurocircuitry of mood disorders
    Joseph L Price
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
    Neuropsychopharmacology 35:192-216. 2010
    ..A large body of human data from functional and structural imaging, as well as analysis of lesions and histological material indicates that this system is centrally involved in mood disorders.
  5. pmc Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
    Int J Methods Psychiatr Res 21:169-84. 2012
    ..Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) anxiety and mood disorders are presented based on US epidemiological surveys among people aged 13+...
  6. pmc Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders
    Gerard Sanacora
    Department of Psychiatry, Clinical Neuroscience Research Unit, Yale University School of Medicine, New Haven, CT, USA
    Neuropharmacology 62:63-77. 2012
    ..This article is part of a Special Issue entitled 'Anxiety and Depression'...
  7. pmc Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Drug Discov 7:426-37. 2008
    b>Mood disorders are common, chronic, recurrent mental illnesses that affect the lives of millions of individuals worldwide...
  8. pmc Circadian genes, rhythms and the biology of mood disorders
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Pharmacol Ther 114:222-32. 2007
    ..many years, researchers have suggested that abnormalities in circadian rhythms may underlie the development of mood disorders such as bipolar disorder (BPD), major depression and seasonal affective disorder (SAD)...
  9. ncbi Effects of suppression and acceptance on emotional responses of individuals with anxiety and mood disorders
    Laura Campbell-Sills
    Department of Psychiatry 0985, University of California, San Diego, 8950 Villa La Jolla Drive, Suite C207, La Jolla, CA 92037, USA
    Behav Res Ther 44:1251-63. 2006
    ..and physiological effects of emotional suppression and acceptance in a sample of individuals with anxiety and mood disorders. Sixty participants diagnosed with anxiety and mood disorders were randomly assigned to one of two groups...
  10. ncbi Prevalence and incidence studies of mood disorders: a systematic review of the literature
    Paul Waraich
    Mental Health Evaluation and Community Consultation Unit, University of British Columbia, Vancouver
    Can J Psychiatry 49:124-38. 2004
    ..the results of a systematic review of literature published between January 1, 1980, and December 31, 2000, that reports findings on the prevalence and incidence of mood disorders in both general population and primary care settings.
  11. pmc The subgenual anterior cingulate cortex in mood disorders
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    CNS Spectr 13:663-81. 2008
    ..In a combined positron emission tomography/magnetic resonance imaging study of mood disorders, we demonstrated that the mean gray matter volume of this "subgenual" ACC (sgACC) cortex is abnormally reduced ..
  12. ncbi Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    Bridget F Grant
    Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9304, USA
    Arch Gen Psychiatry 61:807-16. 2004
    ..Uncertainties exist about the prevalence and comorbidity of substance use disorders and independent mood and anxiety disorders...
  13. ncbi Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging
    Naomi M Simon
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Biol Psychiatry 60:432-5. 2006
    ..is known about the biological mechanisms underlying the excess medical morbidity and mortality associated with mood disorders. Substantial evidence supports abnormalities in stress-related biological systems in depression...
  14. pmc Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders
    Mia Thompson Ray
    Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
    J Psychiatry Neurosci 36:195-203. 2011
    ....
  15. ncbi Increased levels of glutamate in brains from patients with mood disorders
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan
    Biol Psychiatry 62:1310-6. 2007
    ....
  16. ncbi Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Psychiatry Clin Neurosci 64:341-57. 2010
    b>Mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BPD), are the most prevalent psychiatric conditions, and are also among the most severe and debilitating...
  17. pmc The leptin hypothesis of depression: a potential link between mood disorders and obesity?
    Xin Yun Lu
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Curr Opin Pharmacol 7:648-52. 2007
    ....
  18. ncbi Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders
    Monica Beneyto
    Department of Psychiatry, University of Pittsburgh, 3801 O Hara Street, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 32:1888-902. 2007
    ..that abnormal glutamate neurotransmission may be associated with the pathophysiology of schizophrenia and mood disorders. Medial temporal lobe structural alterations have been implicated in schizophrenia and to a lesser extent in ..
  19. ncbi Interaction between BDNF and serotonin: role in mood disorders
    Keri Martinowich
    Mood and Anxiety Disorders Program MAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Neuropsychopharmacology 33:73-83. 2008
    ..of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons...
  20. ncbi The biology of tryptophan depletion and mood disorders
    Lilach Toker
    Psychiatry Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, and Mental Health Center, Beersheva, Israel
    Isr J Psychiatry Relat Sci 47:46-55. 2010
    ..Acute tryptophan depletion as a predictive test for personalized antidepressant treatment is suggested...
  21. pmc GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders
    Etienne Sibille
    Department of Psychiatry, University of Pittsburgh, PA, USA
    Int J Neuropsychopharmacol 14:721-34. 2011
    ..also be present in bipolar disorder (BPD), the specificity of particular GABA-related molecular deficits in mood disorders is not known...
  22. pmc Pattern recognition and functional neuroimaging help to discriminate healthy adolescents at risk for mood disorders from low risk adolescents
    Janaina Mourao-Miranda
    Department of Computer Science, University College London, United Kingdom
    PLoS ONE 7:e29482. 2012
    ..identify those healthy genetically at-risk adolescents who were most likely to develop future Axis I disorders...
  23. ncbi Comorbidity studies of eating disorders and mood disorders. Critical review of the literature
    N T Godart
    Department of Psychiatry, Institut Mutualiste Montsouris IMM, University, René Descartes Paris V, France
    J Affect Disord 97:37-49. 2007
    We conducted a critical literature review of studies assessing the prevalence of mood disorders (MD) in subjects with eating disorders (ED; anorexia nervosa and bulimia nervosa)...
  24. ncbi Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
    Bryan L Roth
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, Ohio 44106, USA
    Nat Rev Drug Discov 3:353-9. 2004
  25. pmc Prevalence and effects of mood disorders on work performance in a nationally representative sample of U.S. workers
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 163:1561-8. 2006
    Research on the workplace costs of mood disorders has focused largely on major depressive episodes...
  26. ncbi Neuroimaging abnormalities in the amygdala in mood disorders
    Wayne C Drevets
    Mood and Anxiety Disorders Program, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 2670, USA
    Ann N Y Acad Sci 985:420-44. 2003
    Neuroimaging technology has been applied to investigate the pathophysiology of mood disorders in studies aimed at characterizing the anatomical correlates of depressive symptoms, the neurophysiological effects of antidepressant treatments,..
  27. ncbi Mood disorders and allostatic load
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Biol Psychiatry 54:200-7. 2003
    ..Allostatic load is seen in major depressive illness and may also be expressed in other chronic anxiety disorders such as PTSD and should be documented...
  28. ncbi Identifying blood biomarkers for mood disorders using convergent functional genomics
    H Le-Niculescu
    Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Mol Psychiatry 14:156-74. 2009
    There are to date no objective clinical laboratory blood tests for mood disorders. The current reliance on patient self-report of symptom severity and on the clinicians' impression is a rate-limiting step in effective treatment and new ..
  29. ncbi Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits
    Richard Levy
    Fédération de Neurologie and INSERM U610, Hopital de la Salpetriere, Paris, France
    Cereb Cortex 16:916-28. 2006
    ..In both situations (direct basal ganglia lesions and nigro-striatal dopaminergic loss), the capacity of the frontal cortex to select, initiate, maintain and shift programs of actions is impaired...
  30. ncbi Biological rhythms and melatonin in mood disorders and their treatments
    Laurence Lanfumey
    INSERM, UMR 894, 75013 Paris, France
    Pharmacol Ther 138:176-84. 2013
    ..on the alterations of melatonin secretion and associated changes in biological rhythms that characterize mood disorders. Causal relationships between alterations in circadian rhythms and mood disorders are strongly supported by ..
  31. ncbi Mortality of patients with mood disorders: follow-up over 34-38 years
    F Angst
    Institute of Social and Preventive Medicine, Zurich University, Zurich, Switzerland
    J Affect Disord 68:167-81. 2002
    ..The reported rates by gender, disorder type and treatment are more variable...
  32. ncbi Decreased glutamic acid decarboxylase(67) mRNA expression in multiple brain areas of patients with schizophrenia and mood disorders
    Mia Thompson
    Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
    J Psychiatr Res 43:970-7. 2009
    ..The resulting decrease in inhibitory tone across multiple brain areas may contribute to the psychotic behavior observed in patients with schizophrenia and bipolar disorder...
  33. pmc Overlapping neurobiology of learned helplessness and conditioned defeat: implications for PTSD and mood disorders
    Sayamwong E Hammack
    Department of Psychology, University of Vermont, 2 Colchester Avenue, John Dewey Hall, Burlington, VT 05405, USA
    Neuropharmacology 62:565-75. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  34. ncbi Reductions in cholesterol and synaptic markers in association cortex in mood disorders
    Clare L Beasley
    Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Bipolar Disord 7:449-55. 2005
    ..While low serum cholesterol has previously been associated with mood disorders, cholesterol levels have yet to be quantified within the brain in these disorders...
  35. pmc Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders
    Keith W Kelley
    Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Brain Behav Immun 25:S13-20. 2011
    Alcohol abuse changes behavior and can induce major mood disorders such as depression...
  36. pmc Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem study
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Res 128:37-43. 2011
    ..These results provide further evidence of GABAergic dysfunction in these three disorders as well as identify potential targets for therapeutic intervention...
  37. pmc Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:617-27. 2005
    ..Little is known about the general population prevalence or severity of DSM-IV mental disorders...
  38. ncbi Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders
    Timothy A Arling
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Nerv Ment Dis 197:905-8. 2009
    ..T.gondii seropositivity and antibody titers were compared between (a) patients with recurrent mood disorders with history of suicide attempt (99 individuals) versus (b) patients with recurrent mood disorders without ..
  39. pmc A review of empirically supported psychological therapies for mood disorders in adults
    Steven D Hollon
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203, USA
    Depress Anxiety 27:891-932. 2010
    The mood disorders are prevalent and problematic...
  40. ncbi GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Schizophr Res 72:109-22. 2005
    ..We hypothesized that levels of GAD and Reelin would be altered in cerebellum of subjects with schizophrenia and mood disorders differentially vs. controls.
  41. ncbi Measurement of temperament and character in mood disorders: a model of fundamental states as personality types
    C R Cloninger
    Washington University Department of Psychiatry and the Center for Psychobiology of Personality, St Louis, MO 63110, USA
    J Affect Disord 51:21-32. 1998
    Personality assessment may allow reliable measurement of risk of mood disorders.
  42. ncbi Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials
    Andrea Cipriani
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 162:1805-19. 2005
    Observational studies suggest that long-term lithium treatment has a strong antisuicidal effect in mood disorders, but it is uncertain whether this association is a genuine therapeutic effect or is due to confounding factors in ..
  43. pmc Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disorders
    Cagri Yüksel
    Istanbul University, Turkey
    Biol Psychiatry 68:785-94. 2010
    In mood disorders, there is growing evidence for glutamatergic abnormalities derived from peripheral measures of glutamatergic metabolites in patients, postmortem studies on glutamate-related markers, and animal studies on the mechanism ..
  44. ncbi The thyroid-brain interaction in thyroid disorders and mood disorders
    M Bauer
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    J Neuroendocrinol 20:1101-14. 2008
    ..Here, we review the relationship between thyroid hormone and neuropsychiatric symptoms in patients with primary thyroid disease and primary mood disorders.
  45. pmc Systematic review of the neural basis of social cognition in patients with mood disorders
    Andrée M Cusi
    Mood Disorders Program, St Joseph s Healthcare Hamilton, McMaster University, Hamilton, ON
    J Psychiatry Neurosci 37:154-69. 2012
    ..The influence of key clinical and method variables on patterns of neural activation during social cognitive processing is also examined...
  46. ncbi The relationship between Toxoplasma gondii infection and mood disorders in the third National Health and Nutrition Survey
    Brad D Pearce
    Department of Epidemiology, Emory University, Rollins School of Public Health, Atlanta, GA 30322, USA
    Biol Psychiatry 72:290-5. 2012
    ..A substantial literature suggests that schizophrenia is associated with increased seroprevalence of T. gondii, but a possible link of the parasite with mood disorders has not been as thoroughly investigated.
  47. ncbi Structural brain abnormalities in first-episode psychosis: differences between affective psychoses and schizophrenia and relationship to clinical outcome
    Pilar de Castro-Manglano
    Section of Neurobiology of Psychosis, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Instituteof Psychiatry, Kings College London, London, UK
    Bipolar Disord 13:545-55. 2011
    ..We then assessed whether baseline MRI abnormalities in the entire sample predicted subsequent clinical outcome...
  48. ncbi Glucocorticoid sensitivity in mood disorders
    A T Spijker
    Department of Mood Disorders, PsyQ The Hague, The Netherlands
    Neuroendocrinology 95:179-86. 2012
    In this review, we provide an overview of recent literature on glucocorticoid (GC) sensitivity in mood disorders. Assessing GC sensitivity is often performed by measuring the cortisol awakening rise (CAR), by challenging the hypothalamic-..
  49. ncbi A web-based approach to managing stress and mood disorders in the workforce
    Douglas W Billings
    ISA Associates, Inc, 201 North Union Street, Suite 330, Alexandria, VA 22314 2650, USA
    J Occup Environ Med 50:960-8. 2008
    ..To evaluate the effectiveness of a web-based multimedia health promotion program for the workplace, designed to help reduce stress and to prevent depression, anxiety, and substance abuse...
  50. pmc The serotonergic system in mood disorders and suicidal behaviour
    J John Mann
    Division of Molecular Imaging and Neuropathology, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10471, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120537. 2013
    ..aggressive traits that are part of the diathesis for suicidal behaviour and are associated with early onset mood disorders and greater risk for suicidal behaviour...
  51. pmc Targeting glutamatergic signaling for the development of novel therapeutics for mood disorders
    Rodrigo Machado-Vieira
    Experimental Therapeutics, Mood and Anxiety Disorders Research Program, National Institute of Mental Health NIH, 10 Center Drive, Bethesda, MD 20892, USA
    Curr Pharm Des 15:1595-611. 2009
    There have been no recent advances in drug development for mood disorders in terms of identifying drug targets that are mechanistically distinct from existing ones...
  52. ncbi Exposure to chronic pregnancy stress reverses peripartum-associated adaptations: implications for postpartum anxiety and mood disorders
    Katharina M Hillerer
    Dept of Behavioral and Molecular Neurobiology, University of Regensburg, 93053 Regensburg, Germany
    Endocrinology 152:3930-40. 2011
    ..Thus, prevention of the peripartum-associated increases in basal corticosterone and oxytocin system activity by pregnancy stress reveal two alterations that may increase the risk of postpartum psychiatric disorders, particularly anxiety...
  53. ncbi Dysfunctional hippocampal activity affects emotion and cognition in mood disorders
    Teresa Femenía
    Dep Neuroscience, Karolinska Institutet, Sweden
    Brain Res 1476:58-70. 2012
    b>Mood disorders, such as major depressive disorder (MDD), bipolar disorder and generalized anxiety disorder usually comprise mood related as well as cognitive symptoms and the interaction between these symptoms is still not clear...
  54. ncbi Chronobiological therapy for mood disorders
    Sara Dallaspezia
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milano, Italy
    Expert Rev Neurother 11:961-70. 2011
    ..about the safety and efficacy of chronobiological treatments in everyday psychiatric settings has supported the inclusion of these techniques among the first-line antidepressant strategies for patients affected by mood disorders.
  55. pmc Association of the GABRD gene and childhood-onset mood disorders
    Y Feng
    Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Genes Brain Behav 9:668-72. 2010
    ..acid A (GABA(A)) delta receptor subunit gene, GABRD, as a susceptibility gene to childhood-onset mood disorders (COMD) because of substantial evidence implicating GABAergic dysfunction in mood disorders and the position of ..
  56. ncbi Current visual scanpath research: a review of investigations into the psychotic, anxiety, and mood disorders
    Wei Lin Toh
    Department of Behavioural Science and Psychiatry, The University of Melbourne, Melbourne, Vic, Australia
    Compr Psychiatry 52:567-79. 2011
    ..and critique of eye movement studies in specific clinical populations involving the psychotic, anxiety, and mood disorders, and concludes with suggested directions for future research...
  57. pmc Gene expression changes in the prefrontal cortex, anterior cingulate cortex and nucleus accumbens of mood disorders subjects that committed suicide
    Adolfo Sequeira
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 7:e35367. 2012
    Suicidal behaviors are frequent in mood disorders patients but only a subset of them ever complete suicide...
  58. ncbi Chronic physical conditions and use of health services among persons with mental disorders: results from the Israel National Health Survey
    Daphna Levinson
    Ministry of Health, Jerusalem, Israel
    Gen Hosp Psychiatry 30:226-32. 2008
    ..This study aimed to determine the association between common mental disorders and common chronic physical conditions and the contribution of mental disorders to the likelihood of being a higher user of health services...
  59. ncbi Volume deficits of subcortical nuclei in mood disorders A postmortem study
    Hendrik Bielau
    Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 255:401-12. 2005
    Structural changes in subcortical nuclei may underlie clinical symptoms of mood disorders. The goal was to determine whether macrostructural changes exist in brain areas assumed to be involved in regulation of mood and whether such ..
  60. ncbi Intracellular signalling pathways and mood disorders
    Z Fisar
    Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Department of Psychiatry, Prague, Czech Republic
    Folia Biol (Praha) 56:135-48. 2010
    ..Psychotropic drugs used in the therapy of a series of mental disorders, mood disorders especially, show neurotrophic or neuroprotective effects after long-term treatment...
  61. ncbi Glial pathology is modified by age in mood disorders--a systematic meta-analysis of serum S100B in vivo studies
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    J Affect Disord 134:32-8. 2011
    b>Mood disorders are characterized by specific glial pathology. Recently, based on histopathological post mortem studies, the glial hypothesis has been discussed as a dynamic process, in particular with regard to glioplasticity...
  62. ncbi Striatal structure and function in mood disorders: a comprehensive review
    William R Marchand
    Department of Veterans Affairs, VISN 19 MIRECC, 5500 Foothill, Salt Lake City, UT 84148, USA
    Bipolar Disord 12:764-85. 2010
    ..Recent functional imaging studies have greatly expanded this body of research. The aim of this review is to provide a comprehensive and critical appraisal of the relevant literature...
  63. pmc Kappa-opioid ligands in the study and treatment of mood disorders
    William A Carlezon
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Ther 123:334-43. 2009
    ..The development of KOR-selective agents with improved drug-like characteristics would facilitate preclinical and clinical studies designed to evaluate the possibility that KORs are a feasible target for new medications...
  64. ncbi Effects of perceived discrimination on mental health and mental health services utilization among gay, lesbian, bisexual and transgender persons
    Diana Burgess
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    J LGBT Health Res 3:1-14. 2007
    ..We examined the extent to which a recent experience of a major discriminatory event may contribute to poor mental health among LGBT persons...
  65. ncbi Bright-light therapy in the treatment of mood disorders
    Gerald Pail
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Neuropsychobiology 64:152-62. 2011
    ..In this review, the authors present a comprehensive overview of the literature on BLT in mood disorders. The first part elucidates the neurobiology of circadian and seasonal adaptive mechanisms focusing on the ..
  66. pmc Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders
    Jennifer Greif Green
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Arch Gen Psychiatry 67:113-23. 2010
    ..Because CAs are highly clustered, this approach results in overestimating the importance of individual CAs. Multivariate CA studies have been based on insufficiently complex models...
  67. ncbi Imaging genetics of mood disorders
    Christian Scharinger
    Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Neuroimage 53:810-21. 2010
    b>Mood disorders are highly heritable and have been linked to brain regions of emotion processing...
  68. ncbi The genetics of mood disorders
    Jennifer Y F Lau
    Department of Experimental Psychology, University of Oxford, 0X1 4AU, United Kingdom
    Annu Rev Clin Psychol 6:313-37. 2010
    Studying the genetics of mood disorders has never been more exciting. We have moved rapidly from establishing the genetic basis of depression to asking questions about how genes are expressed...
  69. ncbi A systems approach to the biology of mood disorders through network analysis of candidate genes
    S D Detera-Wadleigh
    Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 3719, USA
    Pharmacopsychiatry 44:S35-42. 2011
    Meta analysis of association data of mood disorders has shown evidence for the role of particular genes in genetic risk...
  70. ncbi Acceptability and suppression of negative emotion in anxiety and mood disorders
    Laura Campbell-Sills
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    Emotion 6:587-95. 2006
    ..investigated perceived acceptability and suppression of negative emotion in participants with anxiety and mood disorders. Sixty participants with these disorders and 30 control participants watched an emotion-provoking film and ..
  71. ncbi Acceptability of common screening methods used to detect distress and related mood disorders-preferences of cancer specialists and non-specialists
    Alex J Mitchell
    Liaison Psychiatry, University of Leicester, Brandon Unit, Leicester, UK
    Psychooncology 17:226-36. 2008
    ..We suggest that future field studies of screening tools should also measure the issue of acceptability...
  72. pmc Mental disorders among persons with diabetes--results from the World Mental Health Surveys
    Elizabeth H B Lin
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    J Psychosom Res 65:571-80. 2008
    ..We assess whether associations of specific mental disorders with diabetes are consistent across diverse countries after controlling for age and gender...
  73. pmc SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake
    Graziano Pinna
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, United States
    Curr Opin Pharmacol 9:24-30. 2009
    ..Thus, fluoxetine and related congeners facilitate GABA(A) receptor neurotransmission and effectively ameliorate emotional and anxiety disorders and depression by acting as selective brain steroidogenic stimulants (SBSSs)...
  74. ncbi BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects
    Xueying Jiang
    Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 30:1353-61. 2005
    ..01). Our results suggest that in this population, the low activity -281 A allele may be protective against anxiety and psychiatric morbidity, whereas Met 66 may be a risk allele...
  75. ncbi Does pretreatment severity moderate the efficacy of psychological treatment of adult outpatient depression? A meta-analysis
    Ellen Driessen
    Faculty of Psychology and Education, Department of Clinical Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
    J Consult Clin Psychol 78:668-80. 2010
    ..This study assessed whether pretreatment severity moderates psychological treatment outcome relative to controls by means of meta-analyses...
  76. pmc Risk of psychiatric disorders among individuals reporting same-sex sexual partners in the National Comorbidity Survey
    S E Gilman
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Public Health 91:933-9. 2001
    ..Further research is needed to replicate and explore the causal mechanisms underlying this association...
  77. pmc Affective cognition and its disruption in mood disorders
    Rebecca Elliott
    Neuroscience and Psychiatry Unit, School of Community Based Medicine, University of Manchester, Manchester, UK
    Neuropsychopharmacology 36:153-82. 2011
    ..Disturbances of affective cognition are a core and specific feature of mood disorders, and we discuss the evidence supporting this claim, both from behavioral and neuroimaging perspectives...
  78. ncbi The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence
    Robert N Golden
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 162:656-62. 2005
    The purpose of this study was to assess the evidence base for the efficacy of light therapy in treating mood disorders.
  79. pmc Glutamatergic modulators: the future of treating mood disorders?
    Carlos Zarate
    Experimental Therapeutics and Pathophysiology Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Harv Rev Psychiatry 18:293-303. 2010
    b>Mood disorders such as bipolar disorder and major depressive disorder are common, chronic, and recurrent conditions affecting millions of individuals worldwide...
  80. ncbi Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 60:991-7. 2006
    ..This syndrome has been called the "broad BD phenotype" or severe mood dysregulation (SMD). This study examines prevalence, concurrent Axis I diagnoses, and longitudinal outcome of SMD in an epidemiologic sample...
  81. ncbi A family-based approach to the prevention of depressive symptoms in children at risk: evidence of parental and child change
    William R Beardslee
    Judge Baker Children s Center, Boston, Massachusetts 02115, USA
    Pediatrics 112:e119-31. 2003
    ..Our prevention approaches were designed to provide information about mood disorders to parents, to equip parents with the skills they need to communicate information to their children, and to ..
  82. ncbi Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain Res Bull 55:569-78. 2001
    ..Altered cytoarchitecture has also been described in this region in schizophrenia as well as in mood disorders. In this paper we review the literature and present a new study investigating synaptic abnormalities in the ..
  83. ncbi Signaling networks in the pathophysiology and treatment of mood disorders
    Todd D Gould
    Laboratory of Molecular Pathophysiology, NIMH, National Institutes of Health, Building 49, Room B1EE16, Bethesda, MD 20892 4405, USA
    J Psychosom Res 53:687-97. 2002
    Over the past decade, the focus of research into the pathophysiology of mood disorders (bipolar disorder and unipolar depression in particular) has shifted from an interest in the biogenic amines to an emphasis on second messenger systems ..
  84. ncbi Developmental trajectories of depressive symptoms from early childhood to late adolescence: gender differences and adult outcome
    Marielle C Dekker
    Department of Child and Adolescent Psychiatry, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Child Psychol Psychiatry 48:657-66. 2007
    ..Limited information is available on gender differences and young-adult poor outcome in children and adolescents following distinct developmental trajectories of depressive symptoms...
  85. ncbi The circadian basis of mood disorders: recent developments and treatment implications
    Palmiero Monteleone
    Department of Psychiatry, University of Naples SUN, Large Madonna delle Grazie, Naples, Italy
    Eur Neuropsychopharmacol 18:701-11. 2008
    ..b>Mood disorders, especially unipolar depression and seasonal affective disorder, have been linked to circadian rhythm ..
  86. ncbi Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample
    T A Brown
    Center for Anxiety and Related Disorders, Boston University, Massachusetts 02215 2013, USA
    J Abnorm Psychol 110:585-99. 2001
    The comorbidity of current and lifetime DSM-IV anxiety and mood disorders was examined in 1,127 outpatients who were assessed with the Anxiety Disorders Interview Schedule for DSM-IV: Lifetime version (ADIS-IV-L)...
  87. ncbi Three dimensions of oppositionality in youth
    Argyris Stringaris
    King s College London Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 50:216-23. 2009
    ....
  88. ncbi Novel drugs and therapeutic targets for severe mood disorders
    Sanjay J Mathew
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 33:2080-92. 2008
    Monoaminergic-based drugs remain the primary focus of pharmaceutical industry drug discovery efforts for mood disorders, despite serious limitations regarding their ability to achieve remission...
  89. ncbi To what extent do oral contraceptives influence mood and affect?
    Kirsten A Oinonen
    Department of Psychology, Lakehead University, Thunder Bay, Ont, Canada P7B 5E1
    J Affect Disord 70:229-40. 2002
    ..Studies examining the effects of oral contraceptives (OCs) on mood, affect, and affect variability are reviewed...
  90. ncbi Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attempters
    David A Brent
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 59:801-7. 2002
    ..Although adoption, twin, and family studies have shown that suicidal behavior is familial, the risk factors for familial transmission from parent to child remain unclear...
  91. ncbi Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease
    S Rutger Leliveld
    Department of Neuropathology, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
    J Neurosci 28:3839-45. 2008
    ..We conclude that the absence of oligomer-dependent ligand interactions of DISC1 can be associated with sporadic mental disease of mixed phenotypes...
  92. ncbi Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adults
    Jitender Sareen
    Department of Psychiatry, University of Manitoba, 771 Bannatyne Avenue, Winnipeg, Manitoba R3E 3N4, Canada
    Arch Gen Psychiatry 62:1249-57. 2005
    ..Controversy exists whether anxiety disorders are independently associated (ie, after adjusting for comorbid mental disorders) with suicidal ideation and suicide attempts...
  93. ncbi An update on regional brain volume differences associated with mood disorders
    Stephanie Campbell
    McMaster University Medical Centre, Hamilton, Ontario, Canada
    Curr Opin Psychiatry 19:25-33. 2006
    Structural brain changes are apparent in some magnetic resonance imaging studies of patients with mood disorders, but results are inconsistent...
  94. pmc Reduced subgenual cingulate volumes in mood disorders: a meta-analysis
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS
    J Psychiatry Neurosci 33:91-9. 2008
    ..evidence suggests that the subgenual cingulate (SGC) is implicated in regulation of mood and in the pathophysiology of mood disorders. Our objective was to carry out the first meta-analysis of SGC volumes in patients with mood disorders.
  95. ncbi TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament
    Hagop S Akiskal
    Department of Psychiatry, International Mood Center, University of California, San Diego, VA Psychiatry 116A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Affect Disord 85:45-52. 2005
    ..Further item wording and selection were achieved at a later stage through an iterative process that incorporated feedback from clinicians, researchers, and research volunteers...
  96. pmc Review of pharmacological treatment in mood disorders and future directions for drug development
    Xiaohua Li
    Department of Psychiatry and Behavioral Neuroscience, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuropsychopharmacology 37:77-101. 2012
    ..several decades ago, relatively little progress has been made for novel hypothesis-driven drug development in mood disorders. Multifactorial etiologies of, and lack of a full understanding of, the core neurobiology of these conditions ..
  97. ncbi A role for the PKC signaling system in the pathophysiology and treatment of mood disorders: involvement of a functional imbalance?
    Erika Abrial
    Laboratoire de Neuropsychopharmacologie, Universite Lyon 1, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Mol Neurobiol 44:407-19. 2011
    b>Mood disorders, such as bipolar and major depressive disorders, are frequent, severe, and often disabling neuropsychiatric diseases affecting millions of individuals worldwide...
  98. ncbi Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies?
    Boris P Sokolov
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA
    Int J Neuropsychopharmacol 10:547-55. 2007
    ..The possible mechanisms of oligodendroglial abnormalities may involve functional variations in oligodendroglia-related genes, epigenetic regulation of chromatin, DA system hyperactivity and other mechanisms...
  99. pmc Influence of phase-related variability in premenstrual symptomatology, mood, smoking withdrawal, and smoking behavior during ad libitum smoking, on smoking cessation outcome
    Sharon S Allen
    Tobacco Use Research Center, University of Minnesota, Medical School, 2701 University Avenue SE, Suite 201, Minneapolis, MN 55414, United States
    Addict Behav 34:107-11. 2009
    ..These data support the inference that sex hormones influence smoking cessation outcome. This knowledge may contribute to the development of more rational and effective smoking cessation interventions for women...
  100. pmc Identification of sialyltransferase 8B as a generalized susceptibility gene for psychotic and mood disorders on chromosome 15q25-26
    Erica Z McAuley
    Psychiatric Genetics, Neuroscience Research Australia, Sydney, New South Wales, Australia
    PLoS ONE 7:e38172. 2012
    ....
  101. ncbi Sleep deprivation in mood disorders
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Neuropsychobiology 64:141-51. 2011
    ..suggest that this technique can now be included among the first-line antidepressant treatment strategies for mood disorders. SD targets the broadly defined depressive syndrome, and can be administered according to several different ..

Research Grants75

  1. Postpartum Depression: Omega-3 FA vs Placebo
    Marlene Freeman; Fiscal Year: 2006
    ..psychopharmacologic research, statistics, and ethical issues, and 2) to gain expertise in the research on mood disorders during pregnancy and the postpartum period...
  2. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..Metabolic syndrome components (blood pressure, lipids, glucose, anthropometrics), the prevalence of mood disorders, medical history, and health behaviors will be determined using standard clinical procedures and ..
  3. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
    Aberrant norepinephrine [NE] neurotransmission in the human brain is linked to mood disorders, depression, drug addiction and neurodegenerative diseases...
  4. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ..This project may constitute a preliminary step towards elucidating one of the pathophysiological mechanisms of mood disorders, potentially facilitating the development of next-generation antidepressant medications that target this ..
  5. Functional Neuroimaging of Individual Differences in Affect and Motivation
    BRIAN JAMES MICKEY; Fiscal Year: 2013
    ..award aims to train a promising candidate to become an independent investigator in neuroimaging, genetics, and mood disorders while characterizing neurobiological mechanisms that underlie genetic risk for depression. Candidate...
  6. Dietary Supplement Creatine for Adolescent Females with SSRI-Resistant Depression
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..in the brain with translational neuroimaging measures of brain high-energy metabolites that are deficient in mood disorders. Piloting a novel intervention for female adolescents with treatment-resistant major depressive disorder (MDD),..
  7. NEURAL AND ENDOCRINE CONSEQUENCES OF PARITY
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2012
    ..Overall, reproductive experience-induced shifts in endocrine activities may affect endocrine-related diseases and behaviors later in adulthood, i.e. breast cancer, autoimmune diseases, and postpartum mood disorders.
  8. Reversing Corticosteroid-Induced Memory Impairment
    E Sherwood Brown; Fiscal Year: 2013
    ..These have important implications to patients with mood disorders, as a subset of people with major depressive disorder and bipolar disorder have elevated cortisol levels...
  9. Neuroendocrine Mechanisms and Therapeutics in an Animal Model of PTSD
    DAVID MARK DIAMOND; Fiscal Year: 2013
    ..and mechanistic features of PTSD and to develop more effective treatments of stress-induced anxiety and mood disorders. CLINICAL RELEVANCE: Veterans exposed to traumatic stress during combat have a high incidence of anxiety ..
  10. Postpartum Depression: Role of Sleep &Genetic Risk in Postpartum Mood Disorders
    Katherine M Sharkey; Fiscal Year: 2013
    ..5 years of training and research to equip the candidate to examine neurobehavioral and genetic aspects of mood disorders as an independent investigator. The candidate, Katherine M...
  11. Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3
    Eleonore Beurel; Fiscal Year: 2011
    ..which may be particularly important in controlling chronic inflammation that is likely associated with mood disorders. GSK3 also has profound influences in mood disorders, it is inhibited by mood stabilizers and antidepressants, ..
  12. Mechanisms of structural plasticity in stress-related disorders
    Scott J Russo; Fiscal Year: 2013
    ..data from these basic neurobiological studies will lay the groundwork for the development of novel and more selective pharmacological agents targeting nuclear factor kappa B in the brain to treat or prevent anxiety and mood disorders.
  13. A translational model of neuro-immune therapy for PTSD in veterans of the OEF/OIF
    Leonardo H Tonelli; Fiscal Year: 2013
    ..Iraqi Freedom) have a particularly high incidence of PTSD and other mental disorders such as anxiety and mood disorders. A significant problem for the treatment of PTSD is the lack of an appropriate pharmacological or biological ..
  14. Human VGF Polymorphisms and Depression
    Stephen R Salton; Fiscal Year: 2010
    ..both of which are clearly impacted by aging, by degenerative diseases such as Alzheimer's or ALS, and by mood disorders such as depression...
  15. CIRCUITS MEDIATING BEHAVIORAL CONSEQUENCES OF STEROID SENSATION
    Timothy E Holy; Fiscal Year: 2013
    ..understanding of steroid effects in the nervous system offers hope for treatment of stress, anxiety, and mood disorders, as well as to shed light on sex differences in neuronal development...
  16. How do Amine Neurons Work?
    Edward A Kravitz; Fiscal Year: 2013
    ..Disease in which subsets of the dopamine neurons selectively die, and psychiatric disorders including mood disorders, schizophrenia, attention-deficit hyperactivity disorder and drug abuse in which the amines dopamine, ..
  17. Regulation of 22q11 Genes in Embroyonic and Adult Forebrain
    Anthony S LaMantia; Fiscal Year: 2013
    ..vulnerability for language and social cognition deficits, attention deficit/hyperactivity disorder, autism, mood disorders, and schizophrenia...
  18. Novel Role for Sirtuin Signaling Mechanisms and Downstream Targets in Depression
    Deveroux Ferguson; Fiscal Year: 2013
    ..to study the epigenetic mechanisms underlying the gene-environment interactions observed in the onset of major mood disorders. Under the primary mentorship of Dr...
  19. Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3
    Eleonore Beurel; Fiscal Year: 2013
    ..which may be particularly important in controlling chronic inflammation that is likely associated with mood disorders. GSK3 also has profound influences in mood disorders, it is inhibited by mood stabilizers and antidepressants, ..
  20. Web-Based Program to Improve Antidepressant Medication Adherence
    Rebekah K Hersch; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Mood disorders, including major depressive disorder, dysthymia, and bipolar disorder, affect nearly 21 million Americans or 9.5% of the U.S. population age 18 years of age and older...
  21. Using a Biomarker Panel for Detecting Adolescent Depression
    John A Bilello; Fiscal Year: 2010
    ..better less subjective tools are needed to increase the caregivers'ability to identify MDD and other mood disorders within populations...
  22. Omega-3 Fatty Acids &Psychoeducational Psychotherapy for Childhood Depression
    Mary A Fristad; Fiscal Year: 2013
    ..Research on treatment of mood disorders with ?3 is promising (Schacter et al, 2005);however, only one RCT has been conducted in children, which was ..
  23. Endocannabinoid Intracellular Transporters
    Dale G Deutsch; Fiscal Year: 2010
    ..inactivation and identifying FABPs as a new drug target drug target may lead to treatment for addiction, mood disorders, pain and inflammation, cognition, and appetite regulation...
  24. Longitudinal Studies of Autism Spectrum Disorders: 2 to 23
    Catherine Lord; Fiscal Year: 2012
    ..Study 2 will focus more specifically on psychiatric comorbidity and mood disorders in ASD, as well as the relationship between coping resources, comorbidity and quality of life...
  25. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen A McClung; Fiscal Year: 2013
    ..People who have genetic disruptions in circadian gene function are more prone to developing mood disorders such as bipolar disorder or seasonal affective disorder and these disorders are highly co-morbid with ..
  26. Small-molecule probes of chromatin-mediated neuroplasticity
    Stephen J Haggarty; Fiscal Year: 2013
    ..neuroplasticity and the relevance of these mechanisms to the development of novel therapeutics for memory and mood disorders. PUBLIC HEALTH RELEVANCE: Advancing our understanding of brain plasticity and the development of novel ..
  27. Melanocortin Signaling in Depression
    Michael Lutter; Fiscal Year: 2013
    ..Disruptions in appetite and body weight regulation are among the most important concerns to patients with mood disorders. Metabolic diseases including obesity, type II diabetes mellitus and heart disease are all much more common in ..
  28. Vascular and Neural Mechanisms of Serotonin-induced Reduction in Blood Pressure
    Stephanie W Watts; Fiscal Year: 2013
    ..the committed substrate for 5-HT synthesis, 5-hydroxytryptophan (5-HTP), is taken as an aide for sleep, mood disorders, menopause and many other conditions and causes a fall in blood pressure...
  29. Hippocampal plasticity in co-morbid diabetes and depression
    LAWRENCE P contact REAGAN; Fiscal Year: 2010
    ..In this regard, diabetic patients have higher risk to develop mood disorders like depressive illness when compared to non-diabetic individuals...
  30. Cellular Mechanisms for the hormonal Modulation of Sleep
    Jessica Mong; Fiscal Year: 2009
    ..of this research will advance our understanding of steroid associated control of sleep and how changes in hormonal function lead to sleep pathologies, which in women have been medically correlated with mood disorders.
  31. Intervention for Menstrual Mood Disorders &Early Life Abuse: Biopsych Mechanisms
    Susan S Girdler; Fiscal Year: 2013
    ..Menstrually related mood disorders (MRMDs), including premenstrual dysphoric disorder (PMDD), are defined by the cyclic recurrence of affective ..
  32. Seasonality of Mood: A Genome-Wide Association Study in the Old Order Amish
    Teodor T Postolache; Fiscal Year: 2010
    ..Some patients with recurrent mood disorders develop full major depression syndromes in the fall or winter, with full remission in spring or summer, a ..
  33. Coregulatory Processes and Postpartum Depression in Mexican-Americans
    Linda J Luecken; Fiscal Year: 2013
    ..g., mother-infant interactions) for future interventions. PUBLIC HEALTH RELEVANCE: Postpartum mood disorders, primarily depression, affect a large number of new mothers...
  34. Neural Markers of Individual Difference in Emotion Regulation in Depressed Adults
    Jay C Fournier; Fiscal Year: 2013
    ..Dr. Phillips is an expert in the functional neuroimaging of emotion regulation in the context of mood disorders, and Dr. Frank is expert in the assessment and treatment of depression...
  35. BDNF-Trk Signaling &Cytokines in Patients with Mood Disorders
    Ghanshyam N Pandey; Fiscal Year: 2013
    ..In our previously funded grant we studied the roles of the PI and the Wnt signaling pathways in patients with mood disorders (MD)...
  36. Neuroimaging mechanisms of overlap between alcoholism and bipolar disorder
    JAMES JOSEPH PRISCIANDARO; Fiscal Year: 2013
    ..Candidate: Dr. Prisciandaro is a clinical psychologist with extensive training in substance use and mood disorders research and practice, quantitative methods, and initial training in functional Magnetic Resonance Imaging (..
  37. Neural mechanisms underlying abnormal food reward processing in depressed women
    LAURA MCGRATH HOLSEN; Fiscal Year: 2013
    ..in achieving the following goals: a) gain experience in clinical symptomatology and psychiatric treatment of mood disorders, b) develop a knowledge base in the neuroendocrine system, integral to the study of mood disorders and ..
  38. Broadly Neuroprotective Drug for TBI
    Fernando Gomez Pinilla; Fiscal Year: 2010
    ..and energy metabolism disrupted after TBI, in conjunction with CNB-001 effects on counteracting cognitive, mood disorders, and motor dysfunction...
  39. VGF function in depression and antidepressant treatment
    Stephen R Salton; Fiscal Year: 2013
    ..that control emotional behavior and cognition will lead to increased understanding of brain function, mood disorders such as depression, and memory, all clearly impacted by aging and by degenerative diseases including Alzheimer&..
  40. Gonadal Hormones and Depression:The Role of Mood Disorder Risk Gene CACNA1C
    Todd D Gould; Fiscal Year: 2012
    ..It is clear that sex differences are a critical consideration to understanding the pathophysiology of mood disorders. While it is hypothesized as likely that susceptibility genes and hormones interact to modify the development ..
  41. Mechanisms Underlying Sex-Specific Effects of Creatine Supplementation on Depress
    PATRICIA JOAN ALLEN; Fiscal Year: 2011
    ..in the brain, it is essential to more fully characterize the role of this agent in the pathophysiology of mood disorders. Moreover, examining mechanisms underlying sex differences in depression-like behavior in rats in response to ..
  42. Neuroendocrine and Neuroimaging Endophenotypes in Postpartum Depression
    KRISTINA MARIE DELIGIANNIDIS; Fiscal Year: 2013
    ..knowledge gap and will advance scientific knowledge of biomarker identification in gonadal steroid-modulated mood disorders. To my knowledge, it is the first combined GABA MRS/resting-state functional connectivity MRI study in PPD and ..
  43. The Functional Significance of Conformational States in Glutamatergic Signaling
    CATHERINE LOURDES SALUSSOLIA; Fiscal Year: 2013
    ..g. schizophrenia and mood disorders), chronic neurodegenerative diseases (e.g...
  44. Serotonergic Contribution to Adolescent Risk Taking
    ANDREW EMMETT ARRANT; Fiscal Year: 2012
    ..1 as developmental changes in the serotonergic system could affect the emergence of mood disorders and modulate the effects of drugs used to treat these disorders in adolescents...
  45. Vasopressin in the regulation of serotonin and anxiety
    BENJAMIN DAVID ROOD; Fiscal Year: 2013
    ..In particular, anxiety and mood disorders can have devastating effects on social behavior and conversely can be impacted by our social interactions, and ..
  46. Epigenetic modulation of antidepressant efficacy
    Claudia Schmauss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mood disorders are the second leading cause of disability worldwide...
  47. Mechanisms &Effects of Prenatal Maternal Affect on Pregnancy &Infant Development
    Christine Dunkel Schetter; Fiscal Year: 2013
    ..This project will provide important evidence concerning the relationships between antenatal maternal mood disorders, pregnancy-specific stress, and poor pregnancy outcomes, as well as what these relationships mean for infant ..
  48. Influence of physical activity and weight loss on brain plasticity
    Kirk I Erickson; Fiscal Year: 2013
    ..Impaired cognitive and brain function - manifested as mood disorders, impulsivity, and an increased risk for neurological pathology - are often unrecognized consequences of ..
  49. Neuroimaging and Behavioral Biomarkers for ADHD in Children
    Martin H Teicher; Fiscal Year: 2010
    ..disorder had greater impairments in sleep and circadian rhythmicity than children with ADHD and comorbid mood disorders. The validity of these potential markers will be tested in a mixed gender sample of 160 children (80 ADHD, 40 ..
  50. Cholinergic Mechanisms in Spatial Attention
    Anita A Disney; Fiscal Year: 2012
    ..Cognitive and attentional deficits are seen in a number of mental illnesses including schizophrenia, mood disorders and dementias of varying etiology...
  51. Functional and Structural Neuroanatomy in Late-Life Generalized Anxiety Disorder
    Carmen Andreescu; Fiscal Year: 2013
    ..Assistant Professor working in the Advanced Center for Interventions and Services Research for Late-life Mood Disorders (ACISR) at the University of Pittsburgh...
  52. Circadian Clock Genes in Bipolar Disorder
    MICHAEL JOSEPH MCCARTHY; Fiscal Year: 2013
    ..these added skills, the applicant's long-term goal is to develop expertise in the molecular genetics of mood disorders and function as a physician-scientist to develop biologically-based approaches to treating the mentally ill;an ..
  53. p38 MAPK Mechanisms of Kappa Opioid-Induced Aversion
    Charles Chavkin; Fiscal Year: 2013
    ..stress response is generally protective, repeated and uncontrollable stress exposure can increase the risks of mood disorders and drug addiction...
  54. Cellular Circadian Clocks in Mood Disorders
    David K Welsh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Circadian (ca. 24 hr) rhythms are disrupted in mood disorders, and some treatments for mood disorders have specific effects on circadian clocks, pointing to a fundamental connection between cellular ..
  55. Health Promotion and Fitness for Younger and Older Adults With SMI
    Stephen J Bartels; Fiscal Year: 2012
    ..include 200 adults with SMI stratified by diagnostic group (n=100 schizophrenia-spectrum disorders and n=100 mood disorders) and randomized to either: a) In SHAPE, consisting of a personal fitness assessment and development of diet ..
  56. Inflammatory Transcripts, Genes and Positive Valence System Function in Anhedonia
    JERZY ALEKSANDER BODURKA; Fiscal Year: 2013
    ..In pilot studies of individuals presenting with various mood disorders we obtained preliminary evidence that gene expression within PBMCs is abnormal within a gene network ..
  57. Attenuation of Corticosteroid-Induced Hippocampal Changes
    E Sherwood Brown; Fiscal Year: 2013
    ..These findings have important implications for patients with mood disorders, as a subset of people with major depressive disorder and bipolar disorder show evidence of HPA axis ..
  58. HPA Stress Reactivity &Genetic Influences in Postpartum Depression
    SAMANTHA ERIKA MELTZER-BRODY; Fiscal Year: 2013
    ..has two main hypotheses: 1) change in levels rather than direction of change of gonadal hormones may trigger mood disorders;2) genetic variants in stress axis reactivity may predispose to depression in times of flux of gonadal ..
  59. Serotonin 1B Receptor Imaging in Major Depressive Disorder
    Alexander Neumeister; Fiscal Year: 2010
    ..we plan to use as basis for subsequent studies that aim to determine the abnormal processes which underlie mood disorders, guide initial dosing of new therapeutic agents and that are central to predict symptom onset, monitor disease ..
  60. Effects of lithium on cellular signaling
    Richard S Jope; Fiscal Year: 2011
    The etiology of mood disorders is unknown, a critical problem considering their lifetime prevalence of ~20%...
  61. Assessing the Influence of Oxytocin on Postpartum Depression Using Brain Imaging
    Julia R Heiman; Fiscal Year: 2010
    ..The extreme psychosocial and physiological changes inherent to motherhood leave many women vulnerable to mood disorders during the year following the birth of an infant...
  62. A Cognitive Neuroscience Framework for Understanding and Treating Mood Disorders
    Moshe Bar; Fiscal Year: 2012
    ..notably for diagnosing and treating emotional disorders such as depression, for better understanding a host of mood disorders such as, attention-deficit, bi-polar and post traumatic stress disorders, for contextualizing adult ..
  63. NEURAL STEROIDOGENIC ENZYMES AND BRAIN FUNCTION
    BARNETT ALAN SCHLINGER; Fiscal Year: 2013
    ..These studies contribute to an understanding of basic brain function with implications for the treatment of human cognitive and mood disorders.
  64. Use of a mouse model of anxious depression to assess the safety of pediatric anti
    Bernhard Luscher; Fiscal Year: 2010
    ..Evidence that such mechanisms might apply to the neurobiological substrate of anxiety and mood disorders is available from GABA-A receptor gamma2 subunit heterozygous mice (gamma2 mice), which have been established ..
  65. Stress regulation of the endocannabinoid system: Effects on synaptic physiology
    Christian Reich; Fiscal Year: 2009
    ..proposal is to determine the function of the endocannabinoid system in the etiology and pathophysiology of mood disorders. My recent work demonstrated that chronic mild stress, an animal model of depression, differentially regulates ..
  66. Time Course and Potentiation of Fluoxetin Action
    George Battaglia; Fiscal Year: 2004
    ..The long-term goal of the proposed studies is to provide novel therapeutic approaches for the treatment of mood disorders that will work more rapidly and more effectively than the currently available medications...
  67. MENTAL HEALTH RESEARCH TRAINING
    Stanley Watson; Fiscal Year: 2003
    ..postdoctoral fellows in neurobiology and biological psychiatry with particular emphasis on the biology of mood disorders. This program exists in the context of the Mental Health Research Institute (MHRI) of the University of ..
  68. An fMRI study of the brain circuitry of sad emotion in bereavement
    Peter J Freed; Fiscal Year: 2011
    ..specializing in the theory and practice of functional magnetic resonance imaging (fMRI) of mood and mood disorders, with a special focus on the relationship of sad emotion to attentional bias in bereavement...
  69. Serotonin Reuptake Inhibitors and 5-HT1A Receptors
    George Battaglia; Fiscal Year: 2009
    ..that are involved in various physiological functions and play a role in the etiology and/or treatment of mood disorders. Mood disorders are associated with increased activation of the HPA axis that is normalized by antidepressants...
  70. 18F-Mefway for Imaging Mood Disorders and Alzheimer's Disease
    JOGESH MUKHERJEE; Fiscal Year: 2009
    ..Our particular interest is to apply 5HT1A receptor imaging for the study of mood disorders and AD...
  71. INTEGRATED TREATMENT FOR COCAINE AND MOOD DISORDERS
    Joy Schmitz; Fiscal Year: 2003
    ..and logical extension of our previous research evaluating treatments that focus simultaneously on cocaine and mood disorders using integrated cognitive behavioral therapy (CBT) and antidepressant therapy...
  72. Web Tool to Disseminate Empirically-based Interventions to Schools
    MELISSA DEROSIER; Fiscal Year: 2009
    ..demonstrated for a wide array of child behavioral and emotional disorders, including ADHD, suicidality, mood disorders, and conduct disorders...
  73. Neuroimaging Markers of Vulnerability to Depression
    Ronald Dahl; Fiscal Year: 2004
    ..against healthy, low-risk' (LR) controls (who have no evidence of having first or second degree relatives with mood disorders) with respect to PET and MRI imaging measures of neurophysiology, serotoninlA receptor binding potential (BP), ..
  74. Role of Allopregnanolone in Mediating the Adverse Effects of Psychosocial Stress
    Vasiliki Michopoulos; Fiscal Year: 2010
    The incidence of mood disorders, such as anxiety and depression, in women is twice that in men...
  75. IRC FOR THE STUDY OF LATE-LIFE MOOD DISORDERS
    Charles Reynolds; Fiscal Year: 2004
    This application requests support for an Intervention Research Center in Late-Life Mood Disorders (IRC/LLMD) (PAR-98-020) and is the competing continuation of P30 MH52247 (MHCRC for Late-Life Mood Disorders), funded since March 1, 1995...