Genomes and Genes
Summary: Those disorders that have a disturbance in mood as their predominant feature.
Publications316 found, 100 shown here
- Mood disorders in the medically ill: scientific review and recommendationsDwight L Evans
School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
Biol Psychiatry 58:175-89. 2005The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected medical illnesses, review evidence for treatment, and determine needs in clinical ..
- Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depressionWayne C Drevets
Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
Brain Struct Funct 213:93-118. 2008..that putatively modulate aspects of normal emotional behavior have been implicated in the pathophysiology of mood disorders by converging evidence from neuroimaging, neuropathological and lesion analysis studies...
- A neurotrophic model for stress-related mood disordersRonald S Duman
Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
Biol Psychiatry 59:1116-27. 2006....
- Neurocircuitry of mood disordersJoseph L Price
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
Neuropsychopharmacology 35:192-216. 2010..A large body of human data from functional and structural imaging, as well as analysis of lesions and histological material indicates that this system is centrally involved in mood disorders.
- Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disordersGerard Sanacora
Department of Psychiatry, Clinical Neuroscience Research Unit, Yale University School of Medicine, New Haven, CT, USA
Neuropharmacology 62:63-77. 2012..This article is part of a Special Issue entitled 'Anxiety and Depression'...
- Targeting the glutamatergic system to develop novel, improved therapeutics for mood disordersGerard Sanacora
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Nat Rev Drug Discov 7:426-37. 2008b>Mood disorders are common, chronic, recurrent mental illnesses that affect the lives of millions of individuals worldwide...
- Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophreniaBryan L Roth
Department of Biochemistry, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, Ohio 44106, USA
Nat Rev Drug Discov 3:353-9. 2004
- Circadian genes, rhythms and the biology of mood disordersColleen A McClung
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Pharmacol Ther 114:222-32. 2007..many years, researchers have suggested that abnormalities in circadian rhythms may underlie the development of mood disorders such as bipolar disorder (BPD), major depression and seasonal affective disorder (SAD)...
- Decreased glutamic acid decarboxylase(67) mRNA expression in multiple brain areas of patients with schizophrenia and mood disordersMia Thompson
Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
J Psychiatr Res 43:970-7. 2009..The resulting decrease in inhibitory tone across multiple brain areas may contribute to the psychotic behavior observed in patients with schizophrenia and bipolar disorder...
- Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disordersCagri Yüksel
Istanbul University, Turkey
Biol Psychiatry 68:785-94. 2010In mood disorders, there is growing evidence for glutamatergic abnormalities derived from peripheral measures of glutamatergic metabolites in patients, postmortem studies on glutamate-related markers, and animal studies on the mechanism ..
- The subgenual anterior cingulate cortex in mood disordersWayne C Drevets
Section on Neuroimaging in Mood and Anxiety Disorders, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
CNS Spectr 13:663-81. 2008..In a combined positron emission tomography/magnetic resonance imaging study of mood disorders, we demonstrated that the mean gray matter volume of this "subgenual" ACC (sgACC) cortex is abnormally reduced ..
- Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated agingNaomi M Simon
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Biol Psychiatry 60:432-5. 2006..is known about the biological mechanisms underlying the excess medical morbidity and mortality associated with mood disorders. Substantial evidence supports abnormalities in stress-related biological systems in depression...
- Prevalence and incidence studies of mood disorders: a systematic review of the literaturePaul Waraich
Mental Health Evaluation and Community Consultation Unit, University of British Columbia, Vancouver
Can J Psychiatry 49:124-38. 2004..the results of a systematic review of literature published between January 1, 1980, and December 31, 2000, that reports findings on the prevalence and incidence of mood disorders in both general population and primary care settings.
- Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directionsKenji Hashimoto
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Psychiatry Clin Neurosci 64:341-57. 2010b>Mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BPD), are the most prevalent psychiatric conditions, and are also among the most severe and debilitating...
- Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuitsRichard Levy
Fédération de Neurologie and INSERM U610, Hopital de la Salpetriere, Paris, France
Cereb Cortex 16:916-28. 2006..In both situations (direct basal ganglia lesions and nigro-striatal dopaminergic loss), the capacity of the frontal cortex to select, initiate, maintain and shift programs of actions is impaired...
- The leptin hypothesis of depression: a potential link between mood disorders and obesity?Xin Yun Lu
Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Curr Opin Pharmacol 7:648-52. 2007....
- Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disordersMonica Beneyto
Department of Psychiatry, University of Pittsburgh, 3801 O Hara Street, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 32:1888-902. 2007..that abnormal glutamate neurotransmission may be associated with the pathophysiology of schizophrenia and mood disorders. Medial temporal lobe structural alterations have been implicated in schizophrenia and to a lesser extent in ..
- GABA-related transcripts in the dorsolateral prefrontal cortex in mood disordersEtienne Sibille
Department of Psychiatry, University of Pittsburgh, PA, USA
Int J Neuropsychopharmacol 14:721-34. 2011..also be present in bipolar disorder (BPD), the specificity of particular GABA-related molecular deficits in mood disorders is not known...
- Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disordersMia Thompson Ray
Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
J Psychiatry Neurosci 36:195-203. 2011....
- Interaction between BDNF and serotonin: role in mood disordersKeri Martinowich
Mood and Anxiety Disorders Program MAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
Neuropsychopharmacology 33:73-83. 2008..of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons...
- The biology of tryptophan depletion and mood disordersLilach Toker
Psychiatry Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, and Mental Health Center, Beersheva, Israel
Isr J Psychiatry Relat Sci 47:46-55. 2010..Acute tryptophan depletion as a predictive test for personalized antidepressant treatment is suggested...
- Pattern recognition and functional neuroimaging help to discriminate healthy adolescents at risk for mood disorders from low risk adolescentsJanaina Mourao-Miranda
Department of Computer Science, University College London, United Kingdom
PLoS ONE 7:e29482. 2012..identify those healthy genetically at-risk adolescents who were most likely to develop future Axis I disorders...
- Comorbidity studies of eating disorders and mood disorders. Critical review of the literatureN T Godart
Department of Psychiatry, Institut Mutualiste Montsouris IMM, University, René Descartes Paris V, France
J Affect Disord 97:37-49. 2007We conducted a critical literature review of studies assessing the prevalence of mood disorders (MD) in subjects with eating disorders (ED; anorexia nervosa and bulimia nervosa)...
- Increased levels of glutamate in brains from patients with mood disordersKenji Hashimoto
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan
Biol Psychiatry 62:1310-6. 2007....
- A review of empirically supported psychological therapies for mood disorders in adultsSteven D Hollon
Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203, USA
Depress Anxiety 27:891-932. 2010The mood disorders are prevalent and problematic...
- Mood disorders and allostatic loadBruce S McEwen
Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
Biol Psychiatry 54:200-7. 2003..Allostatic load is seen in major depressive illness and may also be expressed in other chronic anxiety disorders such as PTSD and should be documented...
- Identifying blood biomarkers for mood disorders using convergent functional genomicsH Le-Niculescu
Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
Mol Psychiatry 14:156-74. 2009There are to date no objective clinical laboratory blood tests for mood disorders. The current reliance on patient self-report of symptom severity and on the clinicians' impression is a rate-limiting step in effective treatment and new ..
- Alcoholism and inflammation: neuroimmunology of behavioral and mood disordersKeith W Kelley
Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Brain Behav Immun 25:S13-20. 2011Alcohol abuse changes behavior and can induce major mood disorders such as depression...
- Affective cognition and its disruption in mood disordersRebecca Elliott
Neuroscience and Psychiatry Unit, School of Community Based Medicine, University of Manchester, Manchester, UK
Neuropsychopharmacology 36:153-82. 2011..Disturbances of affective cognition are a core and specific feature of mood disorders, and we discuss the evidence supporting this claim, both from behavioral and neuroimaging perspectives...
- Overlapping neurobiology of learned helplessness and conditioned defeat: implications for PTSD and mood disordersSayamwong E Hammack
Department of Psychology, University of Vermont, 2 Colchester Avenue, John Dewey Hall, Burlington, VT 05405, USA
Neuropharmacology 62:565-75. 2012..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
- Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem studyS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
Schizophr Res 128:37-43. 2011..These results provide further evidence of GABAergic dysfunction in these three disorders as well as identify potential targets for therapeutic intervention...
- Reductions in cholesterol and synaptic markers in association cortex in mood disordersClare L Beasley
Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, Canada
Bipolar Disord 7:449-55. 2005..While low serum cholesterol has previously been associated with mood disorders, cholesterol levels have yet to be quantified within the brain in these disorders...
- Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey ReplicationRonald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Gen Psychiatry 62:617-27. 2005..Little is known about the general population prevalence or severity of DSM-IV mental disorders...
- Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trialsAndrea Cipriani
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
Am J Psychiatry 162:1805-19. 2005Observational studies suggest that long-term lithium treatment has a strong antisuicidal effect in mood disorders, but it is uncertain whether this association is a genuine therapeutic effect or is due to confounding factors in ..
- The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidenceRobert N Golden
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
Am J Psychiatry 162:656-62. 2005The purpose of this study was to assess the evidence base for the efficacy of light therapy in treating mood disorders.
- Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related ConditionsBridget F Grant
Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9304, USA
Arch Gen Psychiatry 61:807-16. 2004..Uncertainties exist about the prevalence and comorbidity of substance use disorders and independent mood and anxiety disorders...
- The circadian basis of mood disorders: recent developments and treatment implicationsPalmiero Monteleone
Department of Psychiatry, University of Naples SUN, Large Madonna delle Grazie, Naples, Italy
Eur Neuropsychopharmacol 18:701-11. 2008..b>Mood disorders, especially unipolar depression and seasonal affective disorder, have been linked to circadian rhythm ..
- Measurement of temperament and character in mood disorders: a model of fundamental states as personality typesC R Cloninger
Washington University Department of Psychiatry and the Center for Psychobiology of Personality, St Louis, MO 63110, USA
J Affect Disord 51:21-32. 1998Personality assessment may allow reliable measurement of risk of mood disorders.
- Prevalence and effects of mood disorders on work performance in a nationally representative sample of U.S. workersRonald C Kessler
Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
Am J Psychiatry 163:1561-8. 2006Research on the workplace costs of mood disorders has focused largely on major depressive episodes...
- The thyroid-brain interaction in thyroid disorders and mood disordersM Bauer
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
J Neuroendocrinol 20:1101-14. 2008..Here, we review the relationship between thyroid hormone and neuropsychiatric symptoms in patients with primary thyroid disease and primary mood disorders.
- GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellumS Hossein Fatemi
Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Schizophr Res 72:109-22. 2005..We hypothesized that levels of GAD and Reelin would be altered in cerebellum of subjects with schizophrenia and mood disorders differentially vs. controls.
- Kappa-opioid ligands in the study and treatment of mood disordersWilliam A Carlezon
Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Pharmacol Ther 123:334-43. 2009..The development of KOR-selective agents with improved drug-like characteristics would facilitate preclinical and clinical studies designed to evaluate the possibility that KORs are a feasible target for new medications...
- The genetics of mood disordersJennifer Y F Lau
Department of Experimental Psychology, University of Oxford, 0X1 4AU, United Kingdom
Annu Rev Clin Psychol 6:313-37. 2010Studying the genetics of mood disorders has never been more exciting. We have moved rapidly from establishing the genetic basis of depression to asking questions about how genes are expressed...
- Acceptability and suppression of negative emotion in anxiety and mood disordersLaura Campbell-Sills
Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
Emotion 6:587-95. 2006..investigated perceived acceptability and suppression of negative emotion in participants with anxiety and mood disorders. Sixty participants with these disorders and 30 control participants watched an emotion-provoking film and ..
- Imaging genetics of mood disordersChristian Scharinger
Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Neuroimage 53:810-21. 2010b>Mood disorders are highly heritable and have been linked to brain regions of emotion processing...
- Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disordersJennifer Greif Green
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
Arch Gen Psychiatry 67:113-23. 2010..Because CAs are highly clustered, this approach results in overestimating the importance of individual CAs. Multivariate CA studies have been based on insufficiently complex models...
- Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sampleT A Brown
Center for Anxiety and Related Disorders, Boston University, Massachusetts 02215 2013, USA
J Abnorm Psychol 110:585-99. 2001The comorbidity of current and lifetime DSM-IV anxiety and mood disorders was examined in 1,127 outpatients who were assessed with the Anxiety Disorders Interview Schedule for DSM-IV: Lifetime version (ADIS-IV-L)...
- Intracellular signalling pathways and mood disordersZ Fisar
Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Department of Psychiatry, Prague, Czech Republic
Folia Biol (Praha) 56:135-48. 2010..Psychotropic drugs used in the therapy of a series of mental disorders, mood disorders especially, show neurotrophic or neuroprotective effects after long-term treatment...
- Striatal structure and function in mood disorders: a comprehensive reviewWilliam R Marchand
Department of Veterans Affairs, VISN 19 MIRECC, 5500 Foothill, Salt Lake City, UT 84148, USA
Bipolar Disord 12:764-85. 2010..Recent functional imaging studies have greatly expanded this body of research. The aim of this review is to provide a comprehensive and critical appraisal of the relevant literature...
- Effects of perceived discrimination on mental health and mental health services utilization among gay, lesbian, bisexual and transgender personsDiana Burgess
Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
J LGBT Health Res 3:1-14. 2007..We examined the extent to which a recent experience of a major discriminatory event may contribute to poor mental health among LGBT persons...
- Glial pathology is modified by age in mood disorders--a systematic meta-analysis of serum S100B in vivo studiesMatthias L Schroeter
Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
J Affect Disord 134:32-8. 2011b>Mood disorders are characterized by specific glial pathology. Recently, based on histopathological post mortem studies, the glial hypothesis has been discussed as a dynamic process, in particular with regard to glioplasticity...
- A systems approach to the biology of mood disorders through network analysis of candidate genesS D Detera-Wadleigh
Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 3719, USA
Pharmacopsychiatry 44:S35-42. 2011Meta analysis of association data of mood disorders has shown evidence for the role of particular genes in genetic risk...
- Bright-light therapy in the treatment of mood disordersGerald Pail
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
Neuropsychobiology 64:152-62. 2011..In this review, the authors present a comprehensive overview of the literature on BLT in mood disorders. The first part elucidates the neurobiology of circadian and seasonal adaptive mechanisms focusing on the ..
- Acceptability of common screening methods used to detect distress and related mood disorders-preferences of cancer specialists and non-specialistsAlex J Mitchell
Liaison Psychiatry, University of Leicester, Brandon Unit, Leicester, UK
Psychooncology 17:226-36. 2008..We suggest that future field studies of screening tools should also measure the issue of acceptability...
- Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies?Boris P Sokolov
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA
Int J Neuropsychopharmacol 10:547-55. 2007..The possible mechanisms of oligodendroglial abnormalities may involve functional variations in oligodendroglia-related genes, epigenetic regulation of chromatin, DA system hyperactivity and other mechanisms...
- Glutamatergic modulators: the future of treating mood disorders?Carlos Zarate
Experimental Therapeutics and Pathophysiology Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Harv Rev Psychiatry 18:293-303. 2010b>Mood disorders such as bipolar disorder and major depressive disorder are common, chronic, and recurrent conditions affecting millions of individuals worldwide...
- Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in childrenMelissa A Brotman
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 60:991-7. 2006..This syndrome has been called the "broad BD phenotype" or severe mood dysregulation (SMD). This study examines prevalence, concurrent Axis I diagnoses, and longitudinal outcome of SMD in an epidemiologic sample...
- A family-based approach to the prevention of depressive symptoms in children at risk: evidence of parental and child changeWilliam R Beardslee
Judge Baker Children s Center, Boston, Massachusetts 02115, USA
Pediatrics 112:e119-31. 2003..Our prevention approaches were designed to provide information about mood disorders to parents, to equip parents with the skills they need to communicate information to their children, and to ..
- Developmental trajectories of depressive symptoms from early childhood to late adolescence: gender differences and adult outcomeMarielle C Dekker
Department of Child and Adolescent Psychiatry, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
J Child Psychol Psychiatry 48:657-66. 2007..Limited information is available on gender differences and young-adult poor outcome in children and adolescents following distinct developmental trajectories of depressive symptoms...
- Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexinsS L Eastwood
University Department of Psychiatry, Warneford Hospital, Oxford, UK
Brain Res Bull 55:569-78. 2001..Altered cytoarchitecture has also been described in this region in schizophrenia as well as in mood disorders. In this paper we review the literature and present a new study investigating synaptic abnormalities in the ..
- Signaling networks in the pathophysiology and treatment of mood disordersTodd D Gould
Laboratory of Molecular Pathophysiology, NIMH, National Institutes of Health, Building 49, Room B1EE16, Bethesda, MD 20892 4405, USA
J Psychosom Res 53:687-97. 2002Over the past decade, the focus of research into the pathophysiology of mood disorders (bipolar disorder and unipolar depression in particular) has shifted from an interest in the biogenic amines to an emphasis on second messenger systems ..
- Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental diseaseS Rutger Leliveld
Department of Neuropathology, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
J Neurosci 28:3839-45. 2008..We conclude that the absence of oligomer-dependent ligand interactions of DISC1 can be associated with sporadic mental disease of mixed phenotypes...
- Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adultsJitender Sareen
Department of Psychiatry, University of Manitoba, 771 Bannatyne Avenue, Winnipeg, Manitoba R3E 3N4, Canada
Arch Gen Psychiatry 62:1249-57. 2005..Controversy exists whether anxiety disorders are independently associated (ie, after adjusting for comorbid mental disorders) with suicidal ideation and suicide attempts...
- Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attemptersDavid A Brent
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 59:801-7. 2002..Although adoption, twin, and family studies have shown that suicidal behavior is familial, the risk factors for familial transmission from parent to child remain unclear...
- TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperamentHagop S Akiskal
Department of Psychiatry, International Mood Center, University of California, San Diego, VA Psychiatry 116A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
J Affect Disord 85:45-52. 2005..Further item wording and selection were achieved at a later stage through an iterative process that incorporated feedback from clinicians, researchers, and research volunteers...
- An update on regional brain volume differences associated with mood disordersStephanie Campbell
McMaster University Medical Centre, Hamilton, Ontario, Canada
Curr Opin Psychiatry 19:25-33. 2006Structural brain changes are apparent in some magnetic resonance imaging studies of patients with mood disorders, but results are inconsistent...
- Reduced subgenual cingulate volumes in mood disorders: a meta-analysisTomas Hajek
Department of Psychiatry, Dalhousie University, Halifax, NS
J Psychiatry Neurosci 33:91-9. 2008..evidence suggests that the subgenual cingulate (SGC) is implicated in regulation of mood and in the pathophysiology of mood disorders. Our objective was to carry out the first meta-analysis of SGC volumes in patients with mood disorders.
- Subjective response to and tolerability of long-term supraphysiological doses of levothyroxine in refractory mood disordersM Bauer
Department of Psychiatry, Klinikum Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
J Affect Disord 64:35-42. 2001..This is the first study to investigate subjective patient response and tolerability to long-term treatment with adjunctive T4...
- Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disordersV L Misener
Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
Neuropsychobiology 58:71-80. 2008..Here, we have tested 6 key genes of this type, TNF, IL1A, IL1B, IL6, IL1RN and IL10, as candidates for involvement in childhood-onset mood disorders.
- Self-medication of mood disorders with alcohol and drugs in the National Epidemiologic Survey on Alcohol and Related ConditionsJames M Bolton
Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada
J Affect Disord 115:367-75. 2009..Self-medication has been minimally studied in mood disorders despite equally high rates of alcohol and drug use.
- Novel drugs and therapeutic targets for severe mood disordersSanjay J Mathew
Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Neuropsychopharmacology 33:2080-92. 2008Monoaminergic-based drugs remain the primary focus of pharmaceutical industry drug discovery efforts for mood disorders, despite serious limitations regarding their ability to achieve remission...
- Mood disordersDeborah A Yurgelun-Todd
Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA
Neuroimaging Clin N Am 17:511-21, ix. 2007Despite the prevalence of the mood disorders, the underlying neuropathology is still poorly understood...
- Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disordersTimothy A Arling
Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Nerv Ment Dis 197:905-8. 2009..T.gondii seropositivity and antibody titers were compared between (a) patients with recurrent mood disorders with history of suicide attempt (99 individuals) versus (b) patients with recurrent mood disorders without ..
- The fibroblast growth factor system and mood disordersCortney A Turner
Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
Biol Psychiatry 59:1128-35. 2006Recent evidence now suggests the involvement of the fibroblast growth factor (FGF) system in mood disorders. Specifically, several members of the FGF family have been shown to be dysregulated in individuals with major depression...
- The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the futureMauro Giovanni Carta
Department of Public Health, Division of Psychiatry, University of Cagliari, Italy
BMC Psychiatry 4:25. 2004....
- Validation of the Chinese version of the hypomania checklist (HCL-32) as an instrument for detecting hypo(mania) in patients with mood disordersYi Syuan Wu
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Taiwan, ROC
J Affect Disord 106:133-43. 2008..We aimed to determine the accuracy and validity of the Chinese version of the HCL-32 in an adult psychiatric setting. We also compared the results with prior studies carried out in a comparable sample...
- Development and natural history of mood disordersE Jane Costello
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
Biol Psychiatry 52:529-42. 2002To expand and accelerate research on mood disorders, the National Institute of Mental Health (NIMH) developed a project to formulate a strategic research plan for mood disorder research...
- Pooled results from 38 analyses of the accuracy of distress thermometer and other ultra-short methods of detecting cancer-related mood disordersAlex J Mitchell
Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester, United Kingdom
J Clin Oncol 25:4670-81. 2007..Ultra-short methods were modestly effective in screening for mood disorders. Their rule-in ability was poorer than their rule-out ability...
- Role of neurotrophic factors in the etiology and treatment of mood disordersRonald S Duman
Division of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT, USA
Neuromolecular Med 5:11-25. 2004..This article reviews the primary work leading to a neurotrophic hypothesis of depression and antidepressant action and the cellular mechanisms and signal transduction pathways that underlie these effects...
- Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Neurosci Res 62:211-5. 2008..indicate that the nuclear receptor Rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of mood disorders. To evaluate the association between NR1D1 and mood disorders, we conducted a case-control study of Japanese ..
- Treatment of insomnia in patients with mood disordersP D Nowell
Psychiatry Department, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Depress Anxiety 14:7-18. 2001b>Mood disorders and chronic insomnia share complex theoretical and clinical relationships. This article reviews the subjective symptoms and polysomnographic findings of subjects with mood and insomnia syndromes...
- Increased waist circumference is associated with an increased prevalence of mood disorders and depressive symptoms in obese womenR O Moreira
Obesity and Eating Disorders Group GOTA, Instituto Estadual de Diabetes e Endocrinologia Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro IPUB UFRJ, Rio de Janeiro, Brazil
Eat Weight Disord 12:35-40. 2007..evidence suggesting that obese patients may be more prone to develop certain psychiatric diseases, especially mood disorders. However, no studies have already determined which indicator of fat distribution best explains these ..
- A proposal for a dimensional classification system based on the shared features of the DSM-IV anxiety and mood disorders: implications for assessment and treatmentTimothy A Brown
Center for Anxiety and Related Disorders, Department of Psychology, Boston University, MA 02215 2013, USA
Psychol Assess 21:256-71. 2009..DSM-IV) anxiety and mood disorders. Research has shown that the considerable cross-sectional covariation of DSM-IV emotional disorders is ..
- Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disordersAlessandro Serretti
Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
Psychiatry Res 158:132-40. 2008The exact role of the enzyme glycogen synthase kinase 3beta (GSK-3beta) in mood disorders is still unknown. GSK-3beta has been mapped to chromosome 3q13.3, a potential susceptibility locus for bipolar disorder...
- Heterogeneity of irritability in attention-deficit/hyperactivity disorder subjects with and without mood disordersEric Mick
Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
Biol Psychiatry 58:576-82. 2005..We hypothesized that irritability is a heterogeneous symptom distinguished by severity and that attending to this heterogeneity would impact the relationship between irritability and bipolar disorder...
- Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditionsVincenzo Micale
Department of Experimental and Clinical Pharmacology, University of Catania Medical School, Viale A Doria 6 95125 Catania, Italy
Pharmacol Biochem Behav 90:463-9. 2008..These results give further support to the hypothesis that tachykinin NK2 receptors may be a therapeutic target for pharmacological treatment of stress-related diseases, such as anxiety and depression...
- Velo-cardio-facial syndrome: Implications of microdeletion 22q11 for schizophrenia and mood disordersP D Arnold
The Hospital for Sick Children, University of Toronto, Toronto, Canada
Am J Med Genet 105:354-62. 2001..Of the specific types of disorders, only mood disorders were significantly more common among VCFS subjects compared to sibling controls, with eight VCFS subjects ..
- Use of ecological momentary assessment in mood disorders researchSusan J Wenze
Psychosocial Research Program, Warren Alpert Medical School of Brown University and Butler Hospital, Providence, RI 02906, USA
Clin Psychol Rev 30:794-804. 2010..In this article we discuss benefits of using EMA techniques in mood disorders research, provide an overview of the various specific EMA techniques that have been used with mood-disordered ..
- Mood disorders affect drug treatment success of drug-dependent pregnant womenHeather E Fitzsimons
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Subst Abuse Treat 32:19-25. 2007..These findings highlight the need to treat co-occurring Axis I disorders, particularly given the higher relapse risk for those with mood disorders.
- Switch to mania upon discontinuation of antidepressants in patients with mood disorders: a review of the literatureSherese Ali
Queen s University, Kingston, Ontario
Can J Psychiatry 48:258-64. 2003..To review the literature for reported cases of mania related to discontinuing antidepressant treatment, as well as for possible explanations of this phenomenon, and to present a case report...
- Improving adherence in mood disorders: the struggle against relapse, recurrence and suicide riskMaurizio Pompili
Department of Psychiatry, Sant Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Roma, Italy
Expert Rev Neurother 9:985-1004. 2009..Clinical data highlight the importance of extended courses of medication in improving the long-term prognosis of patients with affective disorders...
- Risk factors and outcome of mood disorders in epilepsy: a case-control studyK Jagadheesan
Central Institute of Psychiatry, Kanke PO, Ranchi 834006, India
Seizure 12:121-5. 2003This case-control study investigated both the risk factors and outcome of mood disorders in epilepsy.
- Disruption of the circadian timing systems: molecular mechanisms in mood disordersJulien Mendlewicz
Department of Psychiatry, Free University of Brussels, Brussels, Belgium
CNS Drugs 23:15-26. 2009....
- Impact of multifamily psychoeducational psychotherapy in treating children aged 8 to 12 years with mood disordersMary A Fristad
Division of Child and Adolescent Psychiatry, Department of Psychiatry, The Ohio State University, 1670 Upham Dr, Ste 460G, Columbus, OH 432101 1250, USA
Arch Gen Psychiatry 66:1013-21. 2009Childhood mood disorders lack sufficient evidence-based treatments. While psychosocial treatments are recommended for both childhood depression and bipolar disorder, empirical support is scarce.
- Novel treatments of mood disorders based on brain circuitry (ECT, MST, TMS, VNS, DBS)Mark S George
Brain Stimulation Laboratory and the Department of Psychiatry, Center for Advanced Imaging Research at the Medical University of South Carolina, Charleston, SC, USA
Semin Clin Neuropsychiatry 7:293-304. 2002..These novel treatments are thus the translational tools to bridge from advances in brain imaging, into new treatments for depressed patients...
- The effectiveness of multi-target agents in schizophrenia and mood disorders: Relevance of receptor signature to clinical actionErik H F Wong
CNS Biology, AstraZeneca Pharmaceutical, Wilmington, DE, USA
Pharmacol Ther 126:173-85. 2010..the knowledge linking receptor signature to clinical activity to drive stronger target validation, and ultimately support rational development of the next generation of MTAs for the improved treatment of schizophrenia and mood disorders.
- Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorderKathleen T Brady
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Carolina 29401, USA
Exp Clin Psychopharmacol 10:276-85. 2002..08) and a significantly longer time to first cocaine use (p = .06). CBZ treatment did not have any impact on cocaine use in individuals without affective disorders...
- Association study of CREB1 and childhood-onset mood disordersI Burcescu
Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
Am J Med Genet B Neuropsychiatr Genet 137:45-50. 2005..We sought to investigate the relationship of CREB1 to childhood-onset mood disorders (COMD) using a sample of 195 nuclear families (225 affected children) collected in Hungary...
- Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregions of the striatum and hippocampus: implications for mood disordersL E Haynes
School of Psychology, University of Birmingham, B15 2TT, Birmingham, UK
Neuroscience 104:57-69. 2001..Equivalent corticosteroid-induced neuronal damage may occur in mood disorders, where the levels of endogenous corticosteroids are often raised...
- No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disordersGil Zalsman
Department of Psychiatry, Division of Neuroscience, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
Arch Suicide Res 12:327-35. 2008..Subjects with mood disorders (N = 486) and healthy volunteers (N = 119), all European Caucasian, were genotyped for COMT-V158M and assessed ..
- Colocalization of corticotropin-releasing hormone and oestrogen receptor-alpha in the paraventricular nucleus of the hypothalamus in mood disordersAi Min Bao
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People s Republic of China
Brain 128:1301-13. 2005..The present study was to investigate whether the activity of the HPA axis in mood disorders might be directly modulated by oestrogens via oestrogen receptors (ORs) in the corticotropin-releasing hormone ..
- Postpartum Depression: Omega-3 FA vs PlaceboMarlene Freeman; Fiscal Year: 2006..psychopharmacologic research, statistics, and ethical issues, and 2) to gain expertise in the research on mood disorders during pregnancy and the postpartum period...
- Gamma-Synuclein-Mediated Regulation of Norepinephrine TransporterAnita Sidhu; Fiscal Year: 2010Aberrant norepinephrine [NE] neurotransmission in the human brain is linked to mood disorders, depression, drug addiction and neurodegenerative diseases...
- Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessMikhail V Pletnikov; Fiscal Year: 2010..where and how mutant DISC1 affects neurodevelopment with relevance to the pathogenesis of schizophrenia and mood disorders. Major mental illnesses have been suggested to arise in part from subtle defects in brain development, ..
- Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessMikhail Pletnikov; Fiscal Year: 2009..where and how mutant DISC1 affects neurodevelopment with relevance to the pathogenesis of schizophrenia and mood disorders. Major mental illnesses have been suggested to arise in part from subtle defects in brain development, ..
- Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2Colleen A McClung; Fiscal Year: 2010..People who have genetic disruptions in circadian gene function are more prone to developing mood disorders such as bipolar disorder or seasonal affective disorder and these disorders are highly co-morbid with ..
- BDNF-Trk Signaling & Cytokines in Patients with Mood DisordersGhanshyam N Pandey; Fiscal Year: 2010In our previously funded grant we studied the roles of the PI and the Wnt signaling pathways in patients with mood disorders (MD)...
- A Cognitive Neuroscience Framework for Understanding and Treating Mood DisordersMoshe Bar; Fiscal Year: 2010..notably for diagnosing and treating emotional disorders such as depression, for better understanding a host of mood disorders such as, attention-deficit, bi-polar and post traumatic stress disorders, for contextualizing adult ..
- Metamoodics: Meta-analyses and bioinformatics display of mood disorders geneticsPeter P Zandi; Fiscal Year: 2010b>Mood disorders impose a significant burden on public health...
- MENTAL HEALTH RESEARCH TRAININGStanley Watson; Fiscal Year: 2003..postdoctoral fellows in neurobiology and biological psychiatry with particular emphasis on the biology of mood disorders. This program exists in the context of the Mental Health Research Institute (MHRI) of the University of ..
- 18F-Mefway for Imaging Mood Disorders and Alzheimer's DiseaseJOGESH MUKHERJEE; Fiscal Year: 2007..Our particular interest is to apply 5HT1A receptor imaging for the study of mood disorders and AD...
- Testing a Neurobiological Model of Primary InsomniaDaniel Buysse; Fiscal Year: 2007..is a prevalent and chronic health problem associated with substantial morbidity, including increased risk for mood disorders. Despite its prevalence and consequences, little is known about insomnia pathophysiology...
- Testing a Neurobiological Model of Primary InsomniaDaniel Buysse; Fiscal Year: 2009..is a prevalent and chronic health problem associated with substantial morbidity, including increased risk for mood disorders. Despite its prevalence and consequences, little is known about insomnia pathophysiology...
- EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITYRICHARD JOPE; Fiscal Year: 2004..Understanding lithium's complex mechanisms of action will help reveal causes of mood disorders and development of targeted drugs...
- INTEGRATED TREATMENT FOR COCAINE AND MOOD DISORDERSJoy Schmitz; Fiscal Year: 2003..and logical extension of our previous research evaluating treatments that focus simultaneously on cocaine and mood disorders using integrated cognitive behavioral therapy (CBT) and antidepressant therapy...
- Neuroimaging Markers of Vulnerability to DepressionRonald Dahl; Fiscal Year: 2004..against healthy, low-risk' (LR) controls (who have no evidence of having first or second degree relatives with mood disorders) with respect to PET and MRI imaging measures of neurophysiology, serotoninlA receptor binding potential (BP), ..
- Psychosocial Treatment for Gynecology Patients with Comorbid Depression and PainELLEN POLESHUCK; Fiscal Year: 2007..foundation for a programmatic line of research developing psychosocial treatments for patients with comorbid mood disorders and chronic pain in primary care, testing them in real world settings, and integrating them into usual ..