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Genomes and Genes
| mood disordersSummarySummary: Those disorders that have a disturbance in mood as their predominant feature. Top Publications
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Publications
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depressionWayne C Drevets
Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
Brain Struct Funct 213:93-118. 2008..that putatively modulate aspects of normal emotional behavior have been implicated in the pathophysiology of mood disorders by converging evidence from neuroimaging, neuropathological and lesion analysis studies...
Mood disorders in the medically ill: scientific review and recommendationsDwight L Evans
School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
Biol Psychiatry 58:175-89. 2005The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected medical illnesses, review evidence for treatment, and determine needs in clinical ..- Comorbidity studies of eating disorders and mood disorders. Critical review of the literatureN T Godart
Department of Psychiatry, Institut Mutualiste Montsouris IMM, University, René Descartes Paris V, France
J Affect Disord 97:37-49. 2007We conducted a critical literature review of studies assessing the prevalence of mood disorders (MD) in subjects with eating disorders (ED; anorexia nervosa and bulimia nervosa)... - A neurotrophic model for stress-related mood disordersRonald S Duman
Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
Biol Psychiatry 59:1116-27. 2006.... - Neurocircuitry of mood disordersJoseph L Price
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
Neuropsychopharmacology 35:192-216. 2010..A large body of human data from functional and structural imaging, as well as analysis of lesions and histological material indicates that this system is centrally involved in mood disorders. 
Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directionsKenji Hashimoto
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Psychiatry Clin Neurosci 64:341-57. 2010b>Mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BPD), are the most prevalent psychiatric conditions, and are also among the most severe and debilitating...- Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey ReplicationRonald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Gen Psychiatry 62:617-27. 2005..Little is known about the general population prevalence or severity of DSM-IV mental disorders... - Measurement of temperament and character in mood disorders: a model of fundamental states as personality typesC R Cloninger
Washington University Department of Psychiatry and the Center for Psychobiology of Personality, St Louis, MO 63110, USA
J Affect Disord 51:21-32. 1998Personality assessment may allow reliable measurement of risk of mood disorders. - The thyroid-brain interaction in thyroid disorders and mood disordersM Bauer
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
J Neuroendocrinol 20:1101-14. 2008..Here, we review the relationship between thyroid hormone and neuropsychiatric symptoms in patients with primary thyroid disease and primary mood disorders. - Acceptability of common screening methods used to detect distress and related mood disorders-preferences of cancer specialists and non-specialistsAlex J Mitchell
Liaison Psychiatry, University of Leicester, Brandon Unit, Leicester, UK
Psychooncology 17:226-36. 2008..We suggest that future field studies of screening tools should also measure the issue of acceptability... - Identifying blood biomarkers for mood disorders using convergent functional genomicsH Le-Niculescu
Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
Mol Psychiatry 14:156-74. 2009There are to date no objective clinical laboratory blood tests for mood disorders. The current reliance on patient self-report of symptom severity and on the clinicians' impression is a rate-limiting step in effective treatment and new .. - Interaction between BDNF and serotonin: role in mood disordersKeri Martinowich
Mood and Anxiety Disorders Program MAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
Neuropsychopharmacology 33:73-83. 2008..of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons... - Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuitsRichard Levy
Fédération de Neurologie and INSERM U610, Hopital de la Salpetriere, Paris, France
Cereb Cortex 16:916-28. 2006..In both situations (direct basal ganglia lesions and nigro-striatal dopaminergic loss), the capacity of the frontal cortex to select, initiate, maintain and shift programs of actions is impaired... - Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related ConditionsBridget F Grant
Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9304, USA
Arch Gen Psychiatry 61:807-16. 2004..Uncertainties exist about the prevalence and comorbidity of substance use disorders and independent mood and anxiety disorders... - The fibroblast growth factor system and mood disordersCortney A Turner
Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
Biol Psychiatry 59:1128-35. 2006Recent evidence now suggests the involvement of the fibroblast growth factor (FGF) system in mood disorders. Specifically, several members of the FGF family have been shown to be dysregulated in individuals with major depression... - Mood disordersDeborah A Yurgelun-Todd
Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA
Neuroimaging Clin N Am 17:511-21, ix. 2007Despite the prevalence of the mood disorders, the underlying neuropathology is still poorly understood... - The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the futureMauro Giovanni Carta
Department of Public Health, Division of Psychiatry, University of Cagliari, Italy
BMC Psychiatry 4:25. 2004.... - The leptin hypothesis of depression: a potential link between mood disorders and obesity?Xin Yun Lu
Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
Curr Opin Pharmacol 7:648-52. 2007.... - Novel drugs and therapeutic targets for severe mood disordersSanjay J Mathew
Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Neuropsychopharmacology 33:2080-92. 2008Monoaminergic-based drugs remain the primary focus of pharmaceutical industry drug discovery efforts for mood disorders, despite serious limitations regarding their ability to achieve remission... - Self-medication of mood disorders with alcohol and drugs in the National Epidemiologic Survey on Alcohol and Related ConditionsJames M Bolton
Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada
J Affect Disord 115:367-75. 2009..Self-medication has been minimally studied in mood disorders despite equally high rates of alcohol and drug use. - Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated agingNaomi M Simon
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Biol Psychiatry 60:432-5. 2006..is known about the biological mechanisms underlying the excess medical morbidity and mortality associated with mood disorders. Substantial evidence supports abnormalities in stress-related biological systems in depression... - Subjective response to and tolerability of long-term supraphysiological doses of levothyroxine in refractory mood disordersM Bauer
Department of Psychiatry, Klinikum Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
J Affect Disord 64:35-42. 2001..This is the first study to investigate subjective patient response and tolerability to long-term treatment with adjunctive T4... - Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disordersTimothy A Arling
Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Nerv Ment Dis 197:905-8. 2009..T.gondii seropositivity and antibody titers were compared between (a) patients with recurrent mood disorders with history of suicide attempt (99 individuals) versus (b) patients with recurrent mood disorders without .. - Glutamatergic modulators: the future of treating mood disorders?Carlos Zarate
Experimental Therapeutics and Pathophysiology Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Harv Rev Psychiatry 18:293-303. 2010b>Mood disorders such as bipolar disorder and major depressive disorder are common, chronic, and recurrent conditions affecting millions of individuals worldwide... - Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disordersV L Misener
Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
Neuropsychobiology 58:71-80. 2008..Here, we have tested 6 key genes of this type, TNF, IL1A, IL1B, IL6, IL1RN and IL10, as candidates for involvement in childhood-onset mood disorders. - Pooled results from 38 analyses of the accuracy of distress thermometer and other ultra-short methods of detecting cancer-related mood disordersAlex J Mitchell
Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester, United Kingdom
J Clin Oncol 25:4670-81. 2007..Ultra-short methods were modestly effective in screening for mood disorders. Their rule-in ability was poorer than their rule-out ability... - Prevalence and effects of mood disorders on work performance in a nationally representative sample of U.S. workersRonald C Kessler
Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
Am J Psychiatry 163:1561-8. 2006Research on the workplace costs of mood disorders has focused largely on major depressive episodes... - Role of neurotrophic factors in the etiology and treatment of mood disordersRonald S Duman
Division of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT, USA
Neuromolecular Med 5:11-25. 2004..This article reviews the primary work leading to a neurotrophic hypothesis of depression and antidepressant action and the cellular mechanisms and signal transduction pathways that underlie these effects... - An update on regional brain volume differences associated with mood disordersStephanie Campbell
McMaster University Medical Centre, Hamilton, Ontario, Canada
Curr Opin Psychiatry 19:25-33. 2006..OF REVIEW: Structural brain changes are apparent in some magnetic resonance imaging studies of patients with mood disorders, but results are inconsistent... - Development and natural history of mood disordersE Jane Costello
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
Biol Psychiatry 52:529-42. 2002To expand and accelerate research on mood disorders, the National Institute of Mental Health (NIMH) developed a project to formulate a strategic research plan for mood disorder research... - Validation of the Chinese version of the hypomania checklist (HCL-32) as an instrument for detecting hypo(mania) in patients with mood disordersYi Syuan Wu
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Taiwan, ROC
J Affect Disord 106:133-43. 2008..We aimed to determine the accuracy and validity of the Chinese version of the HCL-32 in an adult psychiatric setting. We also compared the results with prior studies carried out in a comparable sample... - Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese populationTaro Kishi
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
Neurosci Res 62:211-5. 2008..indicate that the nuclear receptor Rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of mood disorders. To evaluate the association between NR1D1 and mood disorders, we conducted a case-control study of Japanese .. - Striatal structure and function in mood disorders: a comprehensive reviewWilliam R Marchand
Department of Veterans Affairs, VISN 19 MIRECC, 5500 Foothill, Salt Lake City, UT 84148, USA
Bipolar Disord 12:764-85. 2010..Recent functional imaging studies have greatly expanded this body of research. The aim of this review is to provide a comprehensive and critical appraisal of the relevant literature... - Serum contents of the free forms of alpha(1)-microglobulin and ulinastatin: relation to diseased states in patients with mood disordersT Shikimi
Department of Pharmacology, Shimane Medical University, Izumo, Japan
Neuropsychobiology 43:145-9. 2001..The relation between serum contents of the free forms of alpha(1)M and UT in 10 patients with mood disorders was different from that of 17 age-matched healthy subjects... - Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trialsAndrea Cipriani
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
Am J Psychiatry 162:1805-19. 2005Observational studies suggest that long-term lithium treatment has a strong antisuicidal effect in mood disorders, but it is uncertain whether this association is a genuine therapeutic effect or is due to confounding factors in .. - Colocalization of corticotropin-releasing hormone and oestrogen receptor-alpha in the paraventricular nucleus of the hypothalamus in mood disordersAi-Min Bao
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China
Brain 128:1301-13. 2005..The present study was to investigate whether the activity of the HPA axis in mood disorders might be directly modulated by oestrogens via oestrogen receptors (ORs) in the corticotropin-releasing hormone .. - Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditionsVincenzo Micale
Department of Experimental and Clinical Pharmacology, University of Catania Medical School, Viale A Doria 6 95125 Catania, Italy
Pharmacol Biochem Behav 90:463-9. 2008..These results give further support to the hypothesis that tachykinin NK2 receptors may be a therapeutic target for pharmacological treatment of stress-related diseases, such as anxiety and depression... - Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregions of the striatum and hippocampus: implications for mood disordersL E Haynes
School of Psychology, University of Birmingham, B15 2TT, Birmingham, UK
Neuroscience 104:57-69. 2001..Equivalent corticosteroid-induced neuronal damage may occur in mood disorders, where the levels of endogenous corticosteroids are often raised... - Association study of CREB1 and childhood-onset mood disordersI Burcescu
Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
Am J Med Genet B Neuropsychiatr Genet 137:45-50. 2005..We sought to investigate the relationship of CREB1 to childhood-onset mood disorders (COMD) using a sample of 195 nuclear families (225 affected children) collected in Hungary... - Psychometric evaluation of the behavioral inhibition/behavioral activation scales in a large sample of outpatients with anxiety and mood disordersLaura Campbell-Sills
Department of Psychology, Boston University, Boston, MA 02215, USA
Psychol Assess 16:244-54. 2004..L. Carver and T. L. White, 1994) were examined in a large sample of outpatients (N = 1,825) with anxiety and mood disorders. Four subsamples were used for exploratory and confirmatory factor analyses... - Improving adherence in mood disorders: the struggle against relapse, recurrence and suicide riskMaurizio Pompili
Department of Psychiatry, Sant Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Roma, Italy
Expert Rev Neurother 9:985-1004. 2009..Clinical data highlight the importance of extended courses of medication in improving the long-term prognosis of patients with affective disorders... - In vivo proton magnetic resonance spectroscopy in patients with mood disorders: a technically oriented reviewAristides A Capizzano
Psychiatry Department, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
J Magn Reson Imaging 26:1378-89. 2007Proton MR spectroscopy (1HMRS) has been extensively used among mood disorders patients. A review of the published literature in 1HMRS studies of mood disorders was carried out for the period 1991 to July 2006. Of 71 1HMRS studies, 77... - Association analysis between a functional polymorphism in the monoamine oxidase A gene promoter and severe mood disordersBlanca Gutierrez
Unitat d Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Psychiatr Genet 14:203-8. 2004..case-control study design, we analysed the uMAOA polymorphism in 389 unrelated patients affected by severe mood disorders (88 bipolar subjects and 301 major depressive individuals) and in 156 controls... - A review of empirically supported psychological therapies for mood disorders in adultsSteven D Hollon
Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203, USA
Depress Anxiety 27:891-932. 2010The mood disorders are prevalent and problematic... - Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disordersAlessandro Serretti
Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
Psychiatry Res 158:132-40. 2008The exact role of the enzyme glycogen synthase kinase 3beta (GSK-3beta) in mood disorders is still unknown. GSK-3beta has been mapped to chromosome 3q13.3, a potential susceptibility locus for bipolar disorder... - The effectiveness of multi-target agents in schizophrenia and mood disorders: Relevance of receptor signature to clinical actionErik H F Wong
CNS Biology, AstraZeneca Pharmaceutical, Wilmington, DE, USA
Pharmacol Ther 126:173-85. 2010..the knowledge linking receptor signature to clinical activity to drive stronger target validation, and ultimately support rational development of the next generation of MTAs for the improved treatment of schizophrenia and mood disorders. - The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findingsAlessandro Serretti
Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Milan, Italy
Int J Neuropsychopharmacol 7:453-60. 2004..In conclusion, 5-HT1A variants could influence the antidepressant efficacy in bipolar subjects, even if results must be verified on larger samples... - Use of ecological momentary assessment in mood disorders researchSusan J Wenze
Psychosocial Research Program, Warren Alpert Medical School of Brown University and Butler Hospital, Providence, RI 02906, USA
Clin Psychol Rev 30:794-804. 2010..In this article we discuss benefits of using EMA techniques in mood disorders research, provide an overview of the various specific EMA techniques that have been used with mood-disordered .. - Heterogeneity of irritability in attention-deficit/hyperactivity disorder subjects with and without mood disordersEric Mick
Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
Biol Psychiatry 58:576-82. 2005..We hypothesized that irritability is a heterogeneous symptom distinguished by severity and that attending to this heterogeneity would impact the relationship between irritability and bipolar disorder... - Further evidence of a combined effect of SERTPR and TPH on SSRIs response in mood disordersAlessandro Serretti
Department of Psychiatry, Vita Salute University, San Raffaele Institute, Milan, Italy
Am J Med Genet B Neuropsychiatr Genet 129:36-40. 2004..Thus, the previous positive association was not fully replicated for TPH. The present independent replication confirms SERTPR variants as a liability factor for antidepressant efficacy while the TPH effect is not unequivocal... - Increased waist circumference is associated with an increased prevalence of mood disorders and depressive symptoms in obese womenR O Moreira
Obesity and Eating Disorders Group GOTA, Instituto Estadual de Diabetes e Endocrinologia Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro IPUB UFRJ, Rio de Janeiro, Brazil
Eat Weight Disord 12:35-40. 2007..evidence suggesting that obese patients may be more prone to develop certain psychiatric diseases, especially mood disorders. However, no studies have already determined which indicator of fat distribution best explains these .. - Impact of multifamily psychoeducational psychotherapy in treating children aged 8 to 12 years with mood disordersMary A Fristad
Division of Child and Adolescent Psychiatry, Department of Psychiatry, The Ohio State University, 1670 Upham Dr, Ste 460G, Columbus, OH 432101 1250, USA
Arch Gen Psychiatry 66:1013-21. 2009Childhood mood disorders lack sufficient evidence-based treatments. While psychosocial treatments are recommended for both childhood depression and bipolar disorder, empirical support is scarce. - Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorderKathleen T Brady
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Carolina 29401, USA
Exp Clin Psychopharmacol 10:276-85. 2002..08) and a significantly longer time to first cocaine use (p = .06). CBZ treatment did not have any impact on cocaine use in individuals without affective disorders... - Mood disorders affect drug treatment success of drug-dependent pregnant womenHeather E Fitzsimons
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Subst Abuse Treat 32:19-25. 2007..These findings highlight the need to treat co-occurring Axis I disorders, particularly given the higher relapse risk for those with mood disorders. - Treatment of insomnia in patients with mood disordersP D Nowell
Psychiatry Department, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
Depress Anxiety 14:7-18. 2001b>Mood disorders and chronic insomnia share complex theoretical and clinical relationships. This article reviews the subjective symptoms and polysomnographic findings of subjects with mood and insomnia syndromes... - Disruption of the circadian timing systems: molecular mechanisms in mood disordersJulien Mendlewicz
Department of Psychiatry, Free University of Brussels, Brussels, Belgium
CNS Drugs 23:15-26. 2009.... - Novel treatments of mood disorders based on brain circuitry (ECT, MST, TMS, VNS, DBS)Mark S George
Brain Stimulation Laboratory and the Department of Psychiatry, Center for Advanced Imaging Research at the Medical University of South Carolina, Charleston, SC, USA
Semin Clin Neuropsychiatry 7:293-304. 2002..These novel treatments are thus the translational tools to bridge from advances in brain imaging, into new treatments for depressed patients... - Switch to mania upon discontinuation of antidepressants in patients with mood disorders: a review of the literatureSherese Ali
Queen s University, Kingston, Ontario
Can J Psychiatry 48:258-64. 2003..To review the literature for reported cases of mania related to discontinuing antidepressant treatment, as well as for possible explanations of this phenomenon, and to present a case report... - No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disordersGil Zalsman
Department of Psychiatry, Division of Neuroscience, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
Arch Suicide Res 12:327-35. 2008..Subjects with mood disorders (N = 486) and healthy volunteers (N = 119), all European Caucasian, were genotyped for COMT-V158M and assessed .. - Risk factors and outcome of mood disorders in epilepsy: a case-control studyK Jagadheesan
Central Institute of Psychiatry, Kanke (PO, Ranchi-834006, India
Seizure 12:121-5. 2003BACKGROUND: This case-control study investigated both the risk factors and outcome of mood disorders in epilepsy... - Velo-cardio-facial syndrome: Implications of microdeletion 22q11 for schizophrenia and mood disordersP D Arnold
The Hospital for Sick Children, University of Toronto, Toronto, Canada
Am J Med Genet 105:354-62. 2001..Of the specific types of disorders, only mood disorders were significantly more common among VCFS subjects compared to sibling controls, with eight VCFS subjects .. - A proposal for a dimensional classification system based on the shared features of the DSM-IV anxiety and mood disorders: implications for assessment and treatmentTimothy A Brown
Center for Anxiety and Related Disorders, Department of Psychology, Boston University, MA 02215 2013, USA
Psychol Assess 21:256-71. 2009..DSM-IV) anxiety and mood disorders. Research has shown that the considerable cross-sectional covariation of DSM-IV emotional disorders is .. - Pharmacotherapy of comorbid mood, anxiety, and substance use disordersKathleen T Brady
Institute of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Subst Use Misuse 40:2021-41, 2043-8. 2005..Some of the barriers to the use of pharmacotherapy in individuals with substance use disorders are discussed... - Time patterns of attempted suicideHanna Valtonen
Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FI-00300 Helsinki, Finland
J Affect Disord 90:201-7. 2006..There was considerable temporal variation among patients with mood disorders, compared to only slight variation among patients with schizophrenia spectrum disorders... - Psychiatric comorbidity in long-term abstinent alcoholic individualsVictoria Di Sclafani
Neurobehavioral Research Inc, Corte Madera, California 94925, USA
Alcohol Clin Exp Res 31:795-803. 2007..e., comparable with NC) and (2) can ongoing abstinence be maintained in the face of a current psychiatric disorder?.. - The structure of psychosis revisited: the role of mood symptomsMarco P M Boks
The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
Schizophr Res 93:178-85. 2007..The distinction of subgroups of psychosis patients, in particular those with major mood symptoms could facilitate the unravelling of the genetics of psychotic disorders... - Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adultsJitender Sareen
Department of Psychiatry, University of Manitoba, 771 Bannatyne Avenue, Winnipeg, Manitoba R3E 3N4, Canada
Arch Gen Psychiatry 62:1249-57. 2005..Controversy exists whether anxiety disorders are independently associated (ie, after adjusting for comorbid mental disorders) with suicidal ideation and suicide attempts... - Mental disorder comorbidity in Te Rau Hinengaro: the New Zealand Mental Health SurveyKate M Scott
Department of Psychological Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Welliington South, New Zealand
Aust N Z J Psychiatry 40:875-81. 2006..To show the extent and patterning of 12 month mental disorder comorbidity in the New Zealand population, and its association with case severity, suicidality and health service utilization... - Outcome and impact of mental disorders in primary care at 5 yearsJeffrey L Jackson
Department of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Psychosom Med 69:270-6. 2007..To assess 5-year mental disorder recognition rates and determine the natural history of mental disorders in primary care... - Borderline personality disorder and mood spectrumCarmen Berrocal
Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnologies, University of Pisa, Via Roma 67, Pisa 56126, Italy
Psychiatry Res 159:300-7. 2008..BPD) is an independent disease entity or it might be better conceptualized as belonging to the spectrum of mood disorders. This study explores a wide array of lifetime mood features (mood, cognitions, energy, and rhythmicity and .. - Links between eating disorder symptom severity and psychiatric comorbidityAnja Spindler
Psychiatric Department, University Hospital, Culmannstrasse 8, CH 8091 Zurich, Switzerland
Eat Behav 8:364-73. 2007..The results showed that psychiatric comorbidity of both axes is linked with increased severity of ED symptoms and that there are associations between specific ED symptoms and specific forms of comorbidity... - Development of anxiety disorders in a traumatized pediatric population: a preliminary longitudinal evaluationAdriana M Cortes
Rush University Medical Center, Chicago, IL, USA
Child Abuse Negl 29:905-14. 2005..CONCLUSION: Traumatized children with initial PTSD symptomatology may be at risk of later development of other anxiety disorders... - Autism spectrum traits in children with mood and anxiety disordersKenneth E Towbin
Mood and Anxiety Program, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Child Adolesc Psychopharmacol 15:452-64. 2005..Communication Checklist (CCC-2), and the Social Reciprocity Scale (SRS) were used to screen children in a mood disorders research clinic setting for symptoms of ASD. Ninety-three patients (mean age, 12.7 +/- 2... - Association of post-treatment smoking change with future smoking and cessation efforts among adolescents with psychiatric comorbidityLaura MacPherson
Brown University Center for Alcohol and Addictions Studies, Providence, RI, USA
Nicotine Tob Res 9:1297-307. 2007..Findings have implications for initial post-treatment change as it relates to subsequent smoking and cessation outcomes among adolescent smokers at especially high risk for smoking persistence... - The mood-instability hypothesis in the origin of mood-congruent versus mood-incongruent psychotic distinction in mania: validation in a French National Study of 1090 patientsJean Michel Azorin
Ste Marguerite Hospital, University of Marseilles, Marseilles, France
J Affect Disord 96:215-23. 2006..Although included in successive editions of the DSM since its introduction in the IIIrd, the subtyping of manic episode into 'with mood-congruent (MCP) versus mood-incongruent (MIP) psychotic features' is yet to be fully validated... - Psychopathology among cannabis-dependent treatment seekers and association with later substance abuse treatmentMikkel Arendt
Center for Basic Psychiatric Research, Aarhus University Hospital, DK 8240 Risskov, Denmark
J Subst Abuse Treat 32:113-9. 2007.... - Comorbid personality disorder and treatment use in a community sample of youths: a 20-year follow-upS Kasen
Department of Psychiatry, Columbia University, New York, NY, USA
Acta Psychiatr Scand 115:56-65. 2007..The impact of comorbid personality disorder (PD) on subsequent treatment and psychotropic drug use was examined in a representative sample of over 700 individuals... - Psychiatric disorder comorbidity and association with eating disorders in bariatric surgery patients: A cross-sectional study using structured interview-based diagnosisPatricia H Rosenberger
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06519, USA
J Clin Psychiatry 67:1080-5. 2006..The findings highlight the importance of systematic diagnostic assessment using a structured diagnostic interview for determining the full spectrum of Axis I disorders... - Epidemiology of trauma, post-traumatic stress disorder (PTSD) and co-morbid disorders in ChileCaron Zlotnick
Department of Psychiatry and Human Behavior, Brown Medical School and Butler Hospital, Providence, RI 02906, USA
Psychol Med 36:1523-33. 2006.... - Associations between arthritis and a broad range of psychiatric disorders: findings from a nationally representative sampleLachlan A McWilliams
Department of Psychology, Acadia University, Wolfville, Nova Scotia, Canada
J Pain 9:37-44. 2008..However, additional analyses indicated that age was a confounding variable in these relationships and revealed that arthritis was not associated with either alcohol- or substance-related disorders... - Correlates of mental health service use intensity in the National Comorbidity Survey and National Comorbidity Survey ReplicationJon D Elhai
Disaster Mental Health Institute, University of South Dakota, 414 E Clark Street, South Dakota Union 114, Vermillion, SD 57069, USA
Psychiatr Serv 58:1108-15. 2007..This study explored sociodemographic and mental health correlates of intensity of mental health care use in two large-scale surveys, aiming to discover the set of correlates with the greatest predictive capacity... - Fibromyalgia and psychiatric disordersPierluigi Fietta
Department of Psychiatry, Hospital of Lodi, Lodi, Italy
Acta Biomed 78:88-95. 2007..Moreover, elevated frequencies of PD have been detected in relatives of FM patients. The FM/PD aggregation suggests a common physiopathology, and alterations of neurotransmitter systems may constitute the shared underlying factor... - A controlled prospective investigation of psychiatric comorbidity in temporal lobe epilepsyJana E Jones
Department of Neurology and Biostatistics, University of Wisconsin, Madison, Wisconsin 53792, USA
Epilepsia 48:2357-60. 2007..history, epilepsy subjects exhibit significantly greater risk of interval episodes of Total Axis I Disorders and Mood Disorders, indicating a poorer prognosis for these comorbidities in the context of chronic temporal lobe epilepsy. - Mood and anxiety spectrum as a means to identify clinically relevant subtypes of bipolar I disorderAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Bipolar Disord 9:462-7. 2007..We examine the structure of mood and anxiety spectrum features in patients with BD I to identify subtypes with similar profiles... - Preferential aggregation of obsessive-compulsive spectrum disorders in schizophrenia patients with obsessive-compulsive disorderMichael Poyurovsky
Research Unit, Tirat Carmel Mental Health Center, Israel
Can J Psychiatry 51:746-54. 2006..To validate a complex association between schizophrenia and obsessive-compulsive disorder (OCD)... - Reading problems, psychiatric disorders, and functional impairment from mid- to late adolescenceDavid B Goldston
Department of Psychiatry and Behavioral Sciences at Duke University School of Medicine, Durham, NC 27710, USA
J Am Acad Child Adolesc Psychiatry 46:25-32. 2007..To examine psychiatric morbidity and functional impairment of adolescents with and without poor reading skills during mid- to late adolescence... - Serum magnesium profile in heroin addicts: according to psychiatric comorbidityS Daini
Istituto di Psichiatria e Psicologia, Universita Cattolica del Sacro Cuore, Roma, Italy
Magnes Res 19:162-6. 2006..They were subsequently divided in 4 subgroups: No comorbidity, Anxiety Disorders, Mood Disorders, Personality Disorders... - Clinical differences among patients treated for mental health problems in general medical and specialty mental health settings in the National Comorbidity Survey ReplicationLisa A Uebelacker
Department of Psychiatry and Human Behavior, Brown University and Butler Hospital, Providence, RI 02906, USA
Gen Hosp Psychiatry 28:387-95. 2006..We explored whether differences in the clinical characteristics of patients treated in each sector (GM-only or SMH-only) or in both sectors (GM+SMH) may help to explain this finding... - Diagnosis of comorbid psychiatric disorders in substance users assessed with the Psychiatric Research Interview for Substance and Mental Disorders for DSM-IVDeborah Hasin
Columbia University New York State Psychiatric Institute, 1051 Riverside Dr, Box 123, New York, NY 10032, USA
Am J Psychiatry 163:689-96. 2006.... - Longitudinal follow up of primary insomnia patients in a psychiatric clinicSamson Yat Yuk Fong
Department of Psychiatry, Shatin Hospital, and Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
Aust N Z J Psychiatry 41:611-7. 2007..In order to determine the nosological status of primary insomnia, an outcome study was carried out to investigate its diagnostic stability and its relationship to subsequent psychiatric disorders... - Who are the children with severe mood dysregulation, a.k.a. "rages"?Gabrielle A Carlson
Am J Psychiatry 164:1140-2. 2007 - Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related ConditionsKevin P Conway
Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA
J Clin Psychiatry 67:247-57. 2006..Further, definitions of drug use disorder phenotypes should give careful consideration to other psychiatric conditions as meaningful characteristics of case heterogeneity... - Childhood and adulthood psychological ill health as predictors of midlife affective and anxiety disorders: the 1958 British Birth CohortCharlotte Clark
Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Queen Mary s School of Medicine and Dentistry, University of London, London EC1M 6BQ, UK
Arch Gen Psychiatry 64:668-78. 2007..Previous studies have not examined whether the risk associated with childhood psychological ill health persists for midlife psychological health... - Long-term assessment of neuropsychiatric adverse reactions associated with efavirenzP Lochet
Department of Infectious Diseases, Gui de Chauliac Hospital, Montpellier, France
HIV Med 4:62-6. 2003..8%; cognitive disorders: memory disorders 23.0%, impaired concentration 18.9%; anxiety 15.5%; mood disorders: sadness 19.3%, suicidal ideations 9.2%... - Overweight and obesity are associated with psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related ConditionsNancy M Petry
Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3944, USA
Psychosom Med 70:288-97. 2008..This study evaluated associations between body mass index (BMI) and psychiatric disorders... - Psychiatric comorbidities in patients with Parkinson disease and psychosisL Marsh
Department of Psychiatry and Behavioral Sciences, Morris K Udall Parkinson s Disease Research Center of Excellence at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Neurology 63:293-300. 2004..To determine the prevalence and impact of comorbid psychiatric disturbances in Parkinson disease (PD) patients with psychosis... - Utilising survey data to inform public policy: comparison of the cost-effectiveness of treatment of ten mental disordersGavin Andrews
World Health Organization Collaborating Centre for Mental Health Policy, and Policy and Epidemiology Group, School of Psychiatry, University of New South Wales at St Vincent s Hospital, Sydney, Australia
Br J Psychiatry 184:526-33. 2004..Mental health survey data are now being used proactively to decide how the burden of disease might best be reduced... - Symptom characteristics and psychiatric comorbidity among males with muscle dysmorphiaGuy Cafri
Department of Psychology, University of South Florida Tampa, FL 33620 8200, USA
Compr Psychiatry 49:374-9. 2008..This study was designed to further investigate the symptom characteristics and psychiatric conditions associated with the disorder... - National patterns in antidepressant treatment by psychiatrists and general medical providers: results from the national comorbidity survey replicationRamin Mojtabai
Department of Psychiatry, Beth Israel Medical Center, College of Physicians and Surgeons, Columbia University and New York State Psychiatric Institute, New York, NY 10003, USA
J Clin Psychiatry 69:1064-74. 2008..The objective of this study was to compare patient characteristics and treatment patterns of adults in the United States treated with antidepressant medications by psychiatrists and other medical providers... - Blinded, multi-center validation of EEG and rating scales in identifying ADHD within a clinical sampleSteven M Snyder
Department of Psychology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
Psychiatry Res 159:346-58. 2008.... - Considering comorbidity in social phobiaMariette J Chartier
Dept of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Soc Psychiatry Psychiatr Epidemiol 38:728-34. 2003..We also considered whether social fears, reported by respondents with social phobia, had an earlier or later age of onset than other disorders...
Research Grants
- Postpartum Depression: Omega-3 FA vs PlaceboMarlene Freeman; Fiscal Year: 2006..psychopharmacologic research, statistics, and ethical issues, and 2) to gain expertise in the research on mood disorders during pregnancy and the postpartum period...
- Gamma-Synuclein-Mediated Regulation of Norepinephrine TransporterAnita Sidhu; Fiscal Year: 2010Aberrant norepinephrine [NE] neurotransmission in the human brain is linked to mood disorders, depression, drug addiction and neurodegenerative diseases...
- Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessMikhail V Pletnikov; Fiscal Year: 2010..where and how mutant DISC1 affects neurodevelopment with relevance to the pathogenesis of schizophrenia and mood disorders. Major mental illnesses have been suggested to arise in part from subtle defects in brain development, ..
- Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessMikhail Pletnikov; Fiscal Year: 2009..where and how mutant DISC1 affects neurodevelopment with relevance to the pathogenesis of schizophrenia and mood disorders. Major mental illnesses have been suggested to arise in part from subtle defects in brain development, ..
- Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2Colleen A McClung; Fiscal Year: 2010..People who have genetic disruptions in circadian gene function are more prone to developing mood disorders such as bipolar disorder or seasonal affective disorder and these disorders are highly co-morbid with ..
- BDNF-Trk Signaling & Cytokines in Patients with Mood DisordersGhanshyam N Pandey; Fiscal Year: 2010In our previously funded grant we studied the roles of the PI and the Wnt signaling pathways in patients with mood disorders (MD)...
- A Cognitive Neuroscience Framework for Understanding and Treating Mood DisordersMoshe Bar; Fiscal Year: 2010..notably for diagnosing and treating emotional disorders such as depression, for better understanding a host of mood disorders such as, attention-deficit, bi-polar and post traumatic stress disorders, for contextualizing adult ..
- Metamoodics: Meta-analyses and bioinformatics display of mood disorders geneticsPeter P Zandi; Fiscal Year: 2010b>Mood disorders impose a significant burden on public health...
- MENTAL HEALTH RESEARCH TRAININGStanley Watson; Fiscal Year: 2003..postdoctoral fellows in neurobiology and biological psychiatry with particular emphasis on the biology of mood disorders. This program exists in the context of the Mental Health Research Institute (MHRI) of the University of ..
- 18F-Mefway for Imaging Mood Disorders and Alzheimer's DiseaseJOGESH MUKHERJEE; Fiscal Year: 2007..Our particular interest is to apply 5HT1A receptor imaging for the study of mood disorders and AD...
- Testing a Neurobiological Model of Primary InsomniaDaniel Buysse; Fiscal Year: 2009..is a prevalent and chronic health problem associated with substantial morbidity, including increased risk for mood disorders. Despite its prevalence and consequences, little is known about insomnia pathophysiology...
- Testing a Neurobiological Model of Primary InsomniaDaniel Buysse; Fiscal Year: 2007..is a prevalent and chronic health problem associated with substantial morbidity, including increased risk for mood disorders. Despite its prevalence and consequences, little is known about insomnia pathophysiology...
- EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITYRICHARD JOPE; Fiscal Year: 2004..Understanding lithium's complex mechanisms of action will help reveal causes of mood disorders and development of targeted drugs...
- INTEGRATED TREATMENT FOR COCAINE AND MOOD DISORDERSJoy Schmitz; Fiscal Year: 2003..and logical extension of our previous research evaluating treatments that focus simultaneously on cocaine and mood disorders using integrated cognitive behavioral therapy (CBT) and antidepressant therapy...
- Neuroimaging Markers of Vulnerability to DepressionRonald Dahl; Fiscal Year: 2004..against healthy, low-risk' (LR) controls (who have no evidence of having first or second degree relatives with mood disorders) with respect to PET and MRI imaging measures of neurophysiology, serotoninlA receptor binding potential (BP), ..
- Psychosocial Treatment for Gynecology Patients with Comorbid Depression and PainELLEN POLESHUCK; Fiscal Year: 2007..foundation for a programmatic line of research developing psychosocial treatments for patients with comorbid mood disorders and chronic pain in primary care, testing them in real world settings, and integrating them into usual ..