mood disorders

Summary

Summary: Those disorders that have a disturbance in mood as their predominant feature.

Top Publications

  1. ncbi Mood disorders in the medically ill: scientific review and recommendations
    Dwight L Evans
    School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Biol Psychiatry 58:175-89. 2005
  2. pmc Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
    Brain Struct Funct 213:93-118. 2008
  3. ncbi A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
  4. pmc Neurocircuitry of mood disorders
    Joseph L Price
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
    Neuropsychopharmacology 35:192-216. 2010
  5. pmc Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders
    Gerard Sanacora
    Department of Psychiatry, Clinical Neuroscience Research Unit, Yale University School of Medicine, New Haven, CT, USA
    Neuropharmacology 62:63-77. 2012
  6. pmc Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Drug Discov 7:426-37. 2008
  7. ncbi Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
    Bryan L Roth
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, Ohio 44106, USA
    Nat Rev Drug Discov 3:353-9. 2004
  8. pmc Circadian genes, rhythms and the biology of mood disorders
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Pharmacol Ther 114:222-32. 2007
  9. ncbi Decreased glutamic acid decarboxylase(67) mRNA expression in multiple brain areas of patients with schizophrenia and mood disorders
    Mia Thompson
    Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
    J Psychiatr Res 43:970-7. 2009
  10. pmc Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disorders
    Cagri Yüksel
    Istanbul University, Turkey
    Biol Psychiatry 68:785-94. 2010

Detail Information

Publications316 found, 100 shown here

  1. ncbi Mood disorders in the medically ill: scientific review and recommendations
    Dwight L Evans
    School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Biol Psychiatry 58:175-89. 2005
    The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected medical illnesses, review evidence for treatment, and determine needs in clinical ..
  2. pmc Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
    Brain Struct Funct 213:93-118. 2008
    ..that putatively modulate aspects of normal emotional behavior have been implicated in the pathophysiology of mood disorders by converging evidence from neuroimaging, neuropathological and lesion analysis studies...
  3. ncbi A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
    ....
  4. pmc Neurocircuitry of mood disorders
    Joseph L Price
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
    Neuropsychopharmacology 35:192-216. 2010
    ..A large body of human data from functional and structural imaging, as well as analysis of lesions and histological material indicates that this system is centrally involved in mood disorders.
  5. pmc Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders
    Gerard Sanacora
    Department of Psychiatry, Clinical Neuroscience Research Unit, Yale University School of Medicine, New Haven, CT, USA
    Neuropharmacology 62:63-77. 2012
    ..This article is part of a Special Issue entitled 'Anxiety and Depression'...
  6. pmc Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Drug Discov 7:426-37. 2008
    b>Mood disorders are common, chronic, recurrent mental illnesses that affect the lives of millions of individuals worldwide...
  7. ncbi Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
    Bryan L Roth
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 2109 Adelbert Road, Cleveland, Ohio 44106, USA
    Nat Rev Drug Discov 3:353-9. 2004
  8. pmc Circadian genes, rhythms and the biology of mood disorders
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Pharmacol Ther 114:222-32. 2007
    ..many years, researchers have suggested that abnormalities in circadian rhythms may underlie the development of mood disorders such as bipolar disorder (BPD), major depression and seasonal affective disorder (SAD)...
  9. ncbi Decreased glutamic acid decarboxylase(67) mRNA expression in multiple brain areas of patients with schizophrenia and mood disorders
    Mia Thompson
    Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
    J Psychiatr Res 43:970-7. 2009
    ..The resulting decrease in inhibitory tone across multiple brain areas may contribute to the psychotic behavior observed in patients with schizophrenia and bipolar disorder...
  10. pmc Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disorders
    Cagri Yüksel
    Istanbul University, Turkey
    Biol Psychiatry 68:785-94. 2010
    In mood disorders, there is growing evidence for glutamatergic abnormalities derived from peripheral measures of glutamatergic metabolites in patients, postmortem studies on glutamate-related markers, and animal studies on the mechanism ..
  11. pmc The subgenual anterior cingulate cortex in mood disorders
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    CNS Spectr 13:663-81. 2008
    ..In a combined positron emission tomography/magnetic resonance imaging study of mood disorders, we demonstrated that the mean gray matter volume of this "subgenual" ACC (sgACC) cortex is abnormally reduced ..
  12. ncbi Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging
    Naomi M Simon
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Biol Psychiatry 60:432-5. 2006
    ..is known about the biological mechanisms underlying the excess medical morbidity and mortality associated with mood disorders. Substantial evidence supports abnormalities in stress-related biological systems in depression...
  13. ncbi Prevalence and incidence studies of mood disorders: a systematic review of the literature
    Paul Waraich
    Mental Health Evaluation and Community Consultation Unit, University of British Columbia, Vancouver
    Can J Psychiatry 49:124-38. 2004
    ..the results of a systematic review of literature published between January 1, 1980, and December 31, 2000, that reports findings on the prevalence and incidence of mood disorders in both general population and primary care settings.
  14. ncbi Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    Psychiatry Clin Neurosci 64:341-57. 2010
    b>Mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BPD), are the most prevalent psychiatric conditions, and are also among the most severe and debilitating...
  15. ncbi Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits
    Richard Levy
    Fédération de Neurologie and INSERM U610, Hopital de la Salpetriere, Paris, France
    Cereb Cortex 16:916-28. 2006
    ..In both situations (direct basal ganglia lesions and nigro-striatal dopaminergic loss), the capacity of the frontal cortex to select, initiate, maintain and shift programs of actions is impaired...
  16. pmc The leptin hypothesis of depression: a potential link between mood disorders and obesity?
    Xin Yun Lu
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Curr Opin Pharmacol 7:648-52. 2007
    ....
  17. ncbi Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders
    Monica Beneyto
    Department of Psychiatry, University of Pittsburgh, 3801 O Hara Street, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 32:1888-902. 2007
    ..that abnormal glutamate neurotransmission may be associated with the pathophysiology of schizophrenia and mood disorders. Medial temporal lobe structural alterations have been implicated in schizophrenia and to a lesser extent in ..
  18. pmc GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders
    Etienne Sibille
    Department of Psychiatry, University of Pittsburgh, PA, USA
    Int J Neuropsychopharmacol 14:721-34. 2011
    ..also be present in bipolar disorder (BPD), the specificity of particular GABA-related molecular deficits in mood disorders is not known...
  19. pmc Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders
    Mia Thompson Ray
    Stanley Laboratory of Brain Research, Rockville, MD 20850, USA
    J Psychiatry Neurosci 36:195-203. 2011
    ....
  20. ncbi Interaction between BDNF and serotonin: role in mood disorders
    Keri Martinowich
    Mood and Anxiety Disorders Program MAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Neuropsychopharmacology 33:73-83. 2008
    ..of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons...
  21. ncbi The biology of tryptophan depletion and mood disorders
    Lilach Toker
    Psychiatry Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, and Mental Health Center, Beersheva, Israel
    Isr J Psychiatry Relat Sci 47:46-55. 2010
    ..Acute tryptophan depletion as a predictive test for personalized antidepressant treatment is suggested...
  22. pmc Pattern recognition and functional neuroimaging help to discriminate healthy adolescents at risk for mood disorders from low risk adolescents
    Janaina Mourao-Miranda
    Department of Computer Science, University College London, United Kingdom
    PLoS ONE 7:e29482. 2012
    ..identify those healthy genetically at-risk adolescents who were most likely to develop future Axis I disorders...
  23. ncbi Comorbidity studies of eating disorders and mood disorders. Critical review of the literature
    N T Godart
    Department of Psychiatry, Institut Mutualiste Montsouris IMM, University, René Descartes Paris V, France
    J Affect Disord 97:37-49. 2007
    We conducted a critical literature review of studies assessing the prevalence of mood disorders (MD) in subjects with eating disorders (ED; anorexia nervosa and bulimia nervosa)...
  24. ncbi Increased levels of glutamate in brains from patients with mood disorders
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan
    Biol Psychiatry 62:1310-6. 2007
    ....
  25. pmc A review of empirically supported psychological therapies for mood disorders in adults
    Steven D Hollon
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37203, USA
    Depress Anxiety 27:891-932. 2010
    The mood disorders are prevalent and problematic...
  26. ncbi Mood disorders and allostatic load
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Biol Psychiatry 54:200-7. 2003
    ..Allostatic load is seen in major depressive illness and may also be expressed in other chronic anxiety disorders such as PTSD and should be documented...
  27. doi Identifying blood biomarkers for mood disorders using convergent functional genomics
    H Le-Niculescu
    Laboratory of Neurophenomics, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
    Mol Psychiatry 14:156-74. 2009
    There are to date no objective clinical laboratory blood tests for mood disorders. The current reliance on patient self-report of symptom severity and on the clinicians' impression is a rate-limiting step in effective treatment and new ..
  28. pmc Alcoholism and inflammation: neuroimmunology of behavioral and mood disorders
    Keith W Kelley
    Integrative Immunology and Behavior Program, Department of Animal Sciences, College of ACES, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Brain Behav Immun 25:S13-20. 2011
    Alcohol abuse changes behavior and can induce major mood disorders such as depression...
  29. pmc Affective cognition and its disruption in mood disorders
    Rebecca Elliott
    Neuroscience and Psychiatry Unit, School of Community Based Medicine, University of Manchester, Manchester, UK
    Neuropsychopharmacology 36:153-82. 2011
    ..Disturbances of affective cognition are a core and specific feature of mood disorders, and we discuss the evidence supporting this claim, both from behavioral and neuroimaging perspectives...
  30. pmc Overlapping neurobiology of learned helplessness and conditioned defeat: implications for PTSD and mood disorders
    Sayamwong E Hammack
    Department of Psychology, University of Vermont, 2 Colchester Avenue, John Dewey Hall, Burlington, VT 05405, USA
    Neuropharmacology 62:565-75. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  31. pmc Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem study
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, 420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Res 128:37-43. 2011
    ..These results provide further evidence of GABAergic dysfunction in these three disorders as well as identify potential targets for therapeutic intervention...
  32. ncbi Reductions in cholesterol and synaptic markers in association cortex in mood disorders
    Clare L Beasley
    Center for Complex Disorders, Department of Psychiatry, University of British Columbia, Vancouver, Canada
    Bipolar Disord 7:449-55. 2005
    ..While low serum cholesterol has previously been associated with mood disorders, cholesterol levels have yet to be quantified within the brain in these disorders...
  33. pmc Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:617-27. 2005
    ..Little is known about the general population prevalence or severity of DSM-IV mental disorders...
  34. ncbi Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials
    Andrea Cipriani
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 162:1805-19. 2005
    Observational studies suggest that long-term lithium treatment has a strong antisuicidal effect in mood disorders, but it is uncertain whether this association is a genuine therapeutic effect or is due to confounding factors in ..
  35. ncbi The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence
    Robert N Golden
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Am J Psychiatry 162:656-62. 2005
    The purpose of this study was to assess the evidence base for the efficacy of light therapy in treating mood disorders.
  36. ncbi Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    Bridget F Grant
    Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 9304, USA
    Arch Gen Psychiatry 61:807-16. 2004
    ..Uncertainties exist about the prevalence and comorbidity of substance use disorders and independent mood and anxiety disorders...
  37. ncbi The circadian basis of mood disorders: recent developments and treatment implications
    Palmiero Monteleone
    Department of Psychiatry, University of Naples SUN, Large Madonna delle Grazie, Naples, Italy
    Eur Neuropsychopharmacol 18:701-11. 2008
    ..b>Mood disorders, especially unipolar depression and seasonal affective disorder, have been linked to circadian rhythm ..
  38. ncbi Measurement of temperament and character in mood disorders: a model of fundamental states as personality types
    C R Cloninger
    Washington University Department of Psychiatry and the Center for Psychobiology of Personality, St Louis, MO 63110, USA
    J Affect Disord 51:21-32. 1998
    Personality assessment may allow reliable measurement of risk of mood disorders.
  39. pmc Prevalence and effects of mood disorders on work performance in a nationally representative sample of U.S. workers
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 163:1561-8. 2006
    Research on the workplace costs of mood disorders has focused largely on major depressive episodes...
  40. doi The thyroid-brain interaction in thyroid disorders and mood disorders
    M Bauer
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    J Neuroendocrinol 20:1101-14. 2008
    ..Here, we review the relationship between thyroid hormone and neuropsychiatric symptoms in patients with primary thyroid disease and primary mood disorders.
  41. ncbi GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum
    S Hossein Fatemi
    Department of Psychiatry, Division of Neuroscience Research, University of Minnesota Medical School, MMC 392, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Schizophr Res 72:109-22. 2005
    ..We hypothesized that levels of GAD and Reelin would be altered in cerebellum of subjects with schizophrenia and mood disorders differentially vs. controls.
  42. pmc Kappa-opioid ligands in the study and treatment of mood disorders
    William A Carlezon
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Ther 123:334-43. 2009
    ..The development of KOR-selective agents with improved drug-like characteristics would facilitate preclinical and clinical studies designed to evaluate the possibility that KORs are a feasible target for new medications...
  43. doi The genetics of mood disorders
    Jennifer Y F Lau
    Department of Experimental Psychology, University of Oxford, 0X1 4AU, United Kingdom
    Annu Rev Clin Psychol 6:313-37. 2010
    Studying the genetics of mood disorders has never been more exciting. We have moved rapidly from establishing the genetic basis of depression to asking questions about how genes are expressed...
  44. ncbi Acceptability and suppression of negative emotion in anxiety and mood disorders
    Laura Campbell-Sills
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    Emotion 6:587-95. 2006
    ..investigated perceived acceptability and suppression of negative emotion in participants with anxiety and mood disorders. Sixty participants with these disorders and 30 control participants watched an emotion-provoking film and ..
  45. ncbi Imaging genetics of mood disorders
    Christian Scharinger
    Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Neuroimage 53:810-21. 2010
    b>Mood disorders are highly heritable and have been linked to brain regions of emotion processing...
  46. pmc Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders
    Jennifer Greif Green
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Arch Gen Psychiatry 67:113-23. 2010
    ..Because CAs are highly clustered, this approach results in overestimating the importance of individual CAs. Multivariate CA studies have been based on insufficiently complex models...
  47. ncbi Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample
    T A Brown
    Center for Anxiety and Related Disorders, Boston University, Massachusetts 02215 2013, USA
    J Abnorm Psychol 110:585-99. 2001
    The comorbidity of current and lifetime DSM-IV anxiety and mood disorders was examined in 1,127 outpatients who were assessed with the Anxiety Disorders Interview Schedule for DSM-IV: Lifetime version (ADIS-IV-L)...
  48. ncbi Intracellular signalling pathways and mood disorders
    Z Fisar
    Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Department of Psychiatry, Prague, Czech Republic
    Folia Biol (Praha) 56:135-48. 2010
    ..Psychotropic drugs used in the therapy of a series of mental disorders, mood disorders especially, show neurotrophic or neuroprotective effects after long-term treatment...
  49. doi Striatal structure and function in mood disorders: a comprehensive review
    William R Marchand
    Department of Veterans Affairs, VISN 19 MIRECC, 5500 Foothill, Salt Lake City, UT 84148, USA
    Bipolar Disord 12:764-85. 2010
    ..Recent functional imaging studies have greatly expanded this body of research. The aim of this review is to provide a comprehensive and critical appraisal of the relevant literature...
  50. ncbi Effects of perceived discrimination on mental health and mental health services utilization among gay, lesbian, bisexual and transgender persons
    Diana Burgess
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    J LGBT Health Res 3:1-14. 2007
    ..We examined the extent to which a recent experience of a major discriminatory event may contribute to poor mental health among LGBT persons...
  51. doi Glial pathology is modified by age in mood disorders--a systematic meta-analysis of serum S100B in vivo studies
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    J Affect Disord 134:32-8. 2011
    b>Mood disorders are characterized by specific glial pathology. Recently, based on histopathological post mortem studies, the glial hypothesis has been discussed as a dynamic process, in particular with regard to glioplasticity...
  52. doi A systems approach to the biology of mood disorders through network analysis of candidate genes
    S D Detera-Wadleigh
    Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 3719, USA
    Pharmacopsychiatry 44:S35-42. 2011
    Meta analysis of association data of mood disorders has shown evidence for the role of particular genes in genetic risk...
  53. doi Bright-light therapy in the treatment of mood disorders
    Gerald Pail
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    Neuropsychobiology 64:152-62. 2011
    ..In this review, the authors present a comprehensive overview of the literature on BLT in mood disorders. The first part elucidates the neurobiology of circadian and seasonal adaptive mechanisms focusing on the ..
  54. ncbi Acceptability of common screening methods used to detect distress and related mood disorders-preferences of cancer specialists and non-specialists
    Alex J Mitchell
    Liaison Psychiatry, University of Leicester, Brandon Unit, Leicester, UK
    Psychooncology 17:226-36. 2008
    ..We suggest that future field studies of screening tools should also measure the issue of acceptability...
  55. ncbi Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies?
    Boris P Sokolov
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA
    Int J Neuropsychopharmacol 10:547-55. 2007
    ..The possible mechanisms of oligodendroglial abnormalities may involve functional variations in oligodendroglia-related genes, epigenetic regulation of chromatin, DA system hyperactivity and other mechanisms...
  56. pmc Glutamatergic modulators: the future of treating mood disorders?
    Carlos Zarate
    Experimental Therapeutics and Pathophysiology Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Harv Rev Psychiatry 18:293-303. 2010
    b>Mood disorders such as bipolar disorder and major depressive disorder are common, chronic, and recurrent conditions affecting millions of individuals worldwide...
  57. ncbi Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children
    Melissa A Brotman
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 60:991-7. 2006
    ..This syndrome has been called the "broad BD phenotype" or severe mood dysregulation (SMD). This study examines prevalence, concurrent Axis I diagnoses, and longitudinal outcome of SMD in an epidemiologic sample...
  58. ncbi A family-based approach to the prevention of depressive symptoms in children at risk: evidence of parental and child change
    William R Beardslee
    Judge Baker Children s Center, Boston, Massachusetts 02115, USA
    Pediatrics 112:e119-31. 2003
    ..Our prevention approaches were designed to provide information about mood disorders to parents, to equip parents with the skills they need to communicate information to their children, and to ..
  59. ncbi Developmental trajectories of depressive symptoms from early childhood to late adolescence: gender differences and adult outcome
    Marielle C Dekker
    Department of Child and Adolescent Psychiatry, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Child Psychol Psychiatry 48:657-66. 2007
    ..Limited information is available on gender differences and young-adult poor outcome in children and adolescents following distinct developmental trajectories of depressive symptoms...
  60. ncbi Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins
    S L Eastwood
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Brain Res Bull 55:569-78. 2001
    ..Altered cytoarchitecture has also been described in this region in schizophrenia as well as in mood disorders. In this paper we review the literature and present a new study investigating synaptic abnormalities in the ..
  61. ncbi Signaling networks in the pathophysiology and treatment of mood disorders
    Todd D Gould
    Laboratory of Molecular Pathophysiology, NIMH, National Institutes of Health, Building 49, Room B1EE16, Bethesda, MD 20892 4405, USA
    J Psychosom Res 53:687-97. 2002
    Over the past decade, the focus of research into the pathophysiology of mood disorders (bipolar disorder and unipolar depression in particular) has shifted from an interest in the biogenic amines to an emphasis on second messenger systems ..
  62. doi Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease
    S Rutger Leliveld
    Department of Neuropathology, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
    J Neurosci 28:3839-45. 2008
    ..We conclude that the absence of oligomer-dependent ligand interactions of DISC1 can be associated with sporadic mental disease of mixed phenotypes...
  63. ncbi Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adults
    Jitender Sareen
    Department of Psychiatry, University of Manitoba, 771 Bannatyne Avenue, Winnipeg, Manitoba R3E 3N4, Canada
    Arch Gen Psychiatry 62:1249-57. 2005
    ..Controversy exists whether anxiety disorders are independently associated (ie, after adjusting for comorbid mental disorders) with suicidal ideation and suicide attempts...
  64. ncbi Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attempters
    David A Brent
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 59:801-7. 2002
    ..Although adoption, twin, and family studies have shown that suicidal behavior is familial, the risk factors for familial transmission from parent to child remain unclear...
  65. ncbi TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament
    Hagop S Akiskal
    Department of Psychiatry, International Mood Center, University of California, San Diego, VA Psychiatry 116A, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Affect Disord 85:45-52. 2005
    ..Further item wording and selection were achieved at a later stage through an iterative process that incorporated feedback from clinicians, researchers, and research volunteers...
  66. ncbi An update on regional brain volume differences associated with mood disorders
    Stephanie Campbell
    McMaster University Medical Centre, Hamilton, Ontario, Canada
    Curr Opin Psychiatry 19:25-33. 2006
    Structural brain changes are apparent in some magnetic resonance imaging studies of patients with mood disorders, but results are inconsistent...
  67. pmc Reduced subgenual cingulate volumes in mood disorders: a meta-analysis
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS
    J Psychiatry Neurosci 33:91-9. 2008
    ..evidence suggests that the subgenual cingulate (SGC) is implicated in regulation of mood and in the pathophysiology of mood disorders. Our objective was to carry out the first meta-analysis of SGC volumes in patients with mood disorders.
  68. ncbi Subjective response to and tolerability of long-term supraphysiological doses of levothyroxine in refractory mood disorders
    M Bauer
    Department of Psychiatry, Klinikum Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
    J Affect Disord 64:35-42. 2001
    ..This is the first study to investigate subjective patient response and tolerability to long-term treatment with adjunctive T4...
  69. ncbi Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders
    V L Misener
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Neuropsychobiology 58:71-80. 2008
    ..Here, we have tested 6 key genes of this type, TNF, IL1A, IL1B, IL6, IL1RN and IL10, as candidates for involvement in childhood-onset mood disorders.
  70. doi Self-medication of mood disorders with alcohol and drugs in the National Epidemiologic Survey on Alcohol and Related Conditions
    James M Bolton
    Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada
    J Affect Disord 115:367-75. 2009
    ..Self-medication has been minimally studied in mood disorders despite equally high rates of alcohol and drug use.
  71. doi Novel drugs and therapeutic targets for severe mood disorders
    Sanjay J Mathew
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 33:2080-92. 2008
    Monoaminergic-based drugs remain the primary focus of pharmaceutical industry drug discovery efforts for mood disorders, despite serious limitations regarding their ability to achieve remission...
  72. ncbi Mood disorders
    Deborah A Yurgelun-Todd
    Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA
    Neuroimaging Clin N Am 17:511-21, ix. 2007
    Despite the prevalence of the mood disorders, the underlying neuropathology is still poorly understood...
  73. doi Toxoplasma gondii antibody titers and history of suicide attempts in patients with recurrent mood disorders
    Timothy A Arling
    Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Nerv Ment Dis 197:905-8. 2009
    ..T.gondii seropositivity and antibody titers were compared between (a) patients with recurrent mood disorders with history of suicide attempt (99 individuals) versus (b) patients with recurrent mood disorders without ..
  74. ncbi The fibroblast growth factor system and mood disorders
    Cortney A Turner
    Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biol Psychiatry 59:1128-35. 2006
    Recent evidence now suggests the involvement of the fibroblast growth factor (FGF) system in mood disorders. Specifically, several members of the FGF family have been shown to be dysregulated in individuals with major depression...
  75. pmc The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future
    Mauro Giovanni Carta
    Department of Public Health, Division of Psychiatry, University of Cagliari, Italy
    BMC Psychiatry 4:25. 2004
    ..To evaluate the association between mood and anxiety disorders and thyroid autoimmunity in a community sample...
  76. ncbi Validation of the Chinese version of the hypomania checklist (HCL-32) as an instrument for detecting hypo(mania) in patients with mood disorders
    Yi Syuan Wu
    Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Taiwan, ROC
    J Affect Disord 106:133-43. 2008
    ..We aimed to determine the accuracy and validity of the Chinese version of the HCL-32 in an adult psychiatric setting. We also compared the results with prior studies carried out in a comparable sample...
  77. ncbi Development and natural history of mood disorders
    E Jane Costello
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
    Biol Psychiatry 52:529-42. 2002
    To expand and accelerate research on mood disorders, the National Institute of Mental Health (NIMH) developed a project to formulate a strategic research plan for mood disorder research...
  78. ncbi Pooled results from 38 analyses of the accuracy of distress thermometer and other ultra-short methods of detecting cancer-related mood disorders
    Alex J Mitchell
    Department of Cancer and Molecular Medicine, Leicester Royal Infirmary, Leicester, United Kingdom
    J Clin Oncol 25:4670-81. 2007
    ..Ultra-short methods were modestly effective in screening for mood disorders. Their rule-in ability was poorer than their rule-out ability...
  79. ncbi Role of neurotrophic factors in the etiology and treatment of mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT, USA
    Neuromolecular Med 5:11-25. 2004
    ..This article reviews the primary work leading to a neurotrophic hypothesis of depression and antidepressant action and the cellular mechanisms and signal transduction pathways that underlie these effects...
  80. doi Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population
    Taro Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Neurosci Res 62:211-5. 2008
    ..indicate that the nuclear receptor Rev-erb alpha gene (NR1D1) is a good candidate gene for the pathogenesis of mood disorders. To evaluate the association between NR1D1 and mood disorders, we conducted a case-control study of Japanese ..
  81. ncbi Treatment of insomnia in patients with mood disorders
    P D Nowell
    Psychiatry Department, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Depress Anxiety 14:7-18. 2001
    b>Mood disorders and chronic insomnia share complex theoretical and clinical relationships. This article reviews the subjective symptoms and polysomnographic findings of subjects with mood and insomnia syndromes...
  82. ncbi Increased waist circumference is associated with an increased prevalence of mood disorders and depressive symptoms in obese women
    R O Moreira
    Obesity and Eating Disorders Group GOTA, Instituto Estadual de Diabetes e Endocrinologia Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro IPUB UFRJ, Rio de Janeiro, Brazil
    Eat Weight Disord 12:35-40. 2007
    ..evidence suggesting that obese patients may be more prone to develop certain psychiatric diseases, especially mood disorders. However, no studies have already determined which indicator of fat distribution best explains these ..
  83. pmc A proposal for a dimensional classification system based on the shared features of the DSM-IV anxiety and mood disorders: implications for assessment and treatment
    Timothy A Brown
    Center for Anxiety and Related Disorders, Department of Psychology, Boston University, MA 02215 2013, USA
    Psychol Assess 21:256-71. 2009
    ..DSM-IV) anxiety and mood disorders. Research has shown that the considerable cross-sectional covariation of DSM-IV emotional disorders is ..
  84. ncbi Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disorders
    Alessandro Serretti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Psychiatry Res 158:132-40. 2008
    The exact role of the enzyme glycogen synthase kinase 3beta (GSK-3beta) in mood disorders is still unknown. GSK-3beta has been mapped to chromosome 3q13.3, a potential susceptibility locus for bipolar disorder...
  85. ncbi Heterogeneity of irritability in attention-deficit/hyperactivity disorder subjects with and without mood disorders
    Eric Mick
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Biol Psychiatry 58:576-82. 2005
    ..We hypothesized that irritability is a heterogeneous symptom distinguished by severity and that attending to this heterogeneity would impact the relationship between irritability and bipolar disorder...
  86. doi Behavioral effects of saredutant, a tachykinin NK2 receptor antagonist, in experimental models of mood disorders under basal and stress-related conditions
    Vincenzo Micale
    Department of Experimental and Clinical Pharmacology, University of Catania Medical School, Viale A Doria 6 95125 Catania, Italy
    Pharmacol Biochem Behav 90:463-9. 2008
    ..These results give further support to the hypothesis that tachykinin NK2 receptors may be a therapeutic target for pharmacological treatment of stress-related diseases, such as anxiety and depression...
  87. ncbi Velo-cardio-facial syndrome: Implications of microdeletion 22q11 for schizophrenia and mood disorders
    P D Arnold
    The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Am J Med Genet 105:354-62. 2001
    ..Of the specific types of disorders, only mood disorders were significantly more common among VCFS subjects compared to sibling controls, with eight VCFS subjects ..
  88. ncbi Use of ecological momentary assessment in mood disorders research
    Susan J Wenze
    Psychosocial Research Program, Warren Alpert Medical School of Brown University and Butler Hospital, Providence, RI 02906, USA
    Clin Psychol Rev 30:794-804. 2010
    ..In this article we discuss benefits of using EMA techniques in mood disorders research, provide an overview of the various specific EMA techniques that have been used with mood-disordered ..
  89. ncbi Mood disorders affect drug treatment success of drug-dependent pregnant women
    Heather E Fitzsimons
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Subst Abuse Treat 32:19-25. 2007
    ..These findings highlight the need to treat co-occurring Axis I disorders, particularly given the higher relapse risk for those with mood disorders.
  90. ncbi Switch to mania upon discontinuation of antidepressants in patients with mood disorders: a review of the literature
    Sherese Ali
    Queen s University, Kingston, Ontario
    Can J Psychiatry 48:258-64. 2003
    ..To review the literature for reported cases of mania related to discontinuing antidepressant treatment, as well as for possible explanations of this phenomenon, and to present a case report...
  91. doi Improving adherence in mood disorders: the struggle against relapse, recurrence and suicide risk
    Maurizio Pompili
    Department of Psychiatry, Sant Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189 Roma, Italy
    Expert Rev Neurother 9:985-1004. 2009
    ..Clinical data highlight the importance of extended courses of medication in improving the long-term prognosis of patients with affective disorders...
  92. ncbi Risk factors and outcome of mood disorders in epilepsy: a case-control study
    K Jagadheesan
    Central Institute of Psychiatry, Kanke PO, Ranchi 834006, India
    Seizure 12:121-5. 2003
    This case-control study investigated both the risk factors and outcome of mood disorders in epilepsy.
  93. ncbi Disruption of the circadian timing systems: molecular mechanisms in mood disorders
    Julien Mendlewicz
    Department of Psychiatry, Free University of Brussels, Brussels, Belgium
    CNS Drugs 23:15-26. 2009
    ....
  94. doi Impact of multifamily psychoeducational psychotherapy in treating children aged 8 to 12 years with mood disorders
    Mary A Fristad
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, The Ohio State University, 1670 Upham Dr, Ste 460G, Columbus, OH 432101 1250, USA
    Arch Gen Psychiatry 66:1013-21. 2009
    Childhood mood disorders lack sufficient evidence-based treatments. While psychosocial treatments are recommended for both childhood depression and bipolar disorder, empirical support is scarce.
  95. ncbi Novel treatments of mood disorders based on brain circuitry (ECT, MST, TMS, VNS, DBS)
    Mark S George
    Brain Stimulation Laboratory and the Department of Psychiatry, Center for Advanced Imaging Research at the Medical University of South Carolina, Charleston, SC, USA
    Semin Clin Neuropsychiatry 7:293-304. 2002
    ..These novel treatments are thus the translational tools to bridge from advances in brain imaging, into new treatments for depressed patients...
  96. doi The effectiveness of multi-target agents in schizophrenia and mood disorders: Relevance of receptor signature to clinical action
    Erik H F Wong
    CNS Biology, AstraZeneca Pharmaceutical, Wilmington, DE, USA
    Pharmacol Ther 126:173-85. 2010
    ..the knowledge linking receptor signature to clinical activity to drive stronger target validation, and ultimately support rational development of the next generation of MTAs for the improved treatment of schizophrenia and mood disorders.
  97. ncbi Carbamazepine in the treatment of cocaine dependence: subtyping by affective disorder
    Kathleen T Brady
    Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Carolina 29401, USA
    Exp Clin Psychopharmacol 10:276-85. 2002
    ..08) and a significantly longer time to first cocaine use (p = .06). CBZ treatment did not have any impact on cocaine use in individuals without affective disorders...
  98. ncbi Association study of CREB1 and childhood-onset mood disorders
    I Burcescu
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 137:45-50. 2005
    ..We sought to investigate the relationship of CREB1 to childhood-onset mood disorders (COMD) using a sample of 195 nuclear families (225 affected children) collected in Hungary...
  99. ncbi Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregions of the striatum and hippocampus: implications for mood disorders
    L E Haynes
    School of Psychology, University of Birmingham, B15 2TT, Birmingham, UK
    Neuroscience 104:57-69. 2001
    ..Equivalent corticosteroid-induced neuronal damage may occur in mood disorders, where the levels of endogenous corticosteroids are often raised...
  100. pmc No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disorders
    Gil Zalsman
    Department of Psychiatry, Division of Neuroscience, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Arch Suicide Res 12:327-35. 2008
    ..Subjects with mood disorders (N = 486) and healthy volunteers (N = 119), all European Caucasian, were genotyped for COMT-V158M and assessed ..
  101. ncbi Colocalization of corticotropin-releasing hormone and oestrogen receptor-alpha in the paraventricular nucleus of the hypothalamus in mood disorders
    Ai Min Bao
    Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People s Republic of China
    Brain 128:1301-13. 2005
    ..The present study was to investigate whether the activity of the HPA axis in mood disorders might be directly modulated by oestrogens via oestrogen receptors (ORs) in the corticotropin-releasing hormone ..

Research Grants91

  1. Postpartum Depression: Omega-3 FA vs Placebo
    Marlene Freeman; Fiscal Year: 2006
    ..psychopharmacologic research, statistics, and ethical issues, and 2) to gain expertise in the research on mood disorders during pregnancy and the postpartum period...
  2. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2009
    Aberrant norepinephrine [NE] neurotransmission in the human brain is linked to mood disorders, depression, drug addiction and neurodegenerative diseases...
  3. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
    Aberrant norepinephrine [NE] neurotransmission in the human brain is linked to mood disorders, depression, drug addiction and neurodegenerative diseases...
  4. Functional and Structural Neuroanatomy in Late-Life Generalized Anxiety Disorder
    Carmen Andreescu; Fiscal Year: 2010
    ..Assistant Professor working in the Advanced Center for Interventions and Services Research for Late-life Mood Disorders (ACISR) at the University of Pittsburgh...
  5. Use of a mouse model of anxious depression to assess the safety of pediatric anti
    Bernhard Luscher; Fiscal Year: 2010
    ..Evidence that such mechanisms might apply to the neurobiological substrate of anxiety and mood disorders is available from GABA-A receptor gamma2 subunit heterozygous mice (gamma2 mice), which have been established ..
  6. Use of a mouse model of anxious depression to assess the safety of pediatric anti
    Bernhard Luscher; Fiscal Year: 2009
    ..Evidence that such mechanisms might apply to the neurobiological substrate of anxiety and mood disorders is available from GABA-A receptor gamma2 subunit heterozygous mice (gamma2 mice), which have been established ..
  7. Postpartum Depression: Role of Sleep & Genetic Risk in Postpartum Mood Disorders
    Katherine M Sharkey; Fiscal Year: 2011
    ..5 years of training and research to equip the candidate to examine neurobehavioral and genetic aspects of mood disorders as an independent investigator. The candidate, Katherine M...
  8. Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3
    Eleonore Beurel; Fiscal Year: 2010
    ..which may be particularly important in controlling chronic inflammation that is likely associated with mood disorders. GSK3 also has profound influences in mood disorders, it is inhibited by mood stabilizers and antidepressants, ..
  9. Effects of Stress and Glutamatergic Agents on Glutamate Cycling and Behavior
    Gerard Sanacora; Fiscal Year: 2009
    ..of Glu-modulating agents possess antidepressant-like properties in animal models, as well as in patients with mood disorders, thus providing additional support for the connection between Glu neurotransmission and MDD...
  10. Prevention of PTSD by Early Treatment II: Telephone-Based CBT
    Arieh Y Shalev; Fiscal Year: 2010
    ..Telephone based CBT has been successfully delivered in anxiety and mood disorders. Studies of populations under threat show that telephone support services are widely used...
  11. Postpartum Depression: Omega-3 FA vs Placebo
    Marlene Freeman; Fiscal Year: 2002
    ..psychopharmacologic research, statistics, and ethical issues, and 2) to gain expertise in the research on mood disorders during pregnancy and the postpartum period...
  12. Postpartum Depression: Omega-3 FA vs Placebo
    Marlene Freeman; Fiscal Year: 2003
    ..psychopharmacologic research, statistics, and ethical issues, and 2) to gain expertise in the research on mood disorders during pregnancy and the postpartum period...
  13. Postpartum Depression: Omega-3 FA vs Placebo
    Marlene Freeman; Fiscal Year: 2004
    ..psychopharmacologic research, statistics, and ethical issues, and 2) to gain expertise in the research on mood disorders during pregnancy and the postpartum period...
  14. Postpartum Depression: Omega-3 FA vs Placebo
    Marlene Freeman; Fiscal Year: 2005
    ..psychopharmacologic research, statistics, and ethical issues, and 2) to gain expertise in the research on mood disorders during pregnancy and the postpartum period...
  15. Mutant DISC 1 and Abnormal Neurodevelopment in Mental Illness
    Mikhail V Pletnikov; Fiscal Year: 2010
    ..where and how mutant DISC1 affects neurodevelopment with relevance to the pathogenesis of schizophrenia and mood disorders. Major mental illnesses have been suggested to arise in part from subtle defects in brain development, ..
  16. Mutant DISC 1 and Abnormal Neurodevelopment in Mental Illness
    Mikhail Pletnikov; Fiscal Year: 2009
    ..where and how mutant DISC1 affects neurodevelopment with relevance to the pathogenesis of schizophrenia and mood disorders. Major mental illnesses have been suggested to arise in part from subtle defects in brain development, ..
  17. Stress regulation of the endocannabinoid system: Effects on synaptic physiology
    Christian Reich; Fiscal Year: 2009
    ..proposal is to determine the function of the endocannabinoid system in the etiology and pathophysiology of mood disorders. My recent work demonstrated that chronic mild stress, an animal model of depression, differentially regulates ..
  18. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen A McClung; Fiscal Year: 2011
    ..People who have genetic disruptions in circadian gene function are more prone to developing mood disorders such as bipolar disorder or seasonal affective disorder and these disorders are highly co-morbid with ..
  19. Behavioral manifestation and therapeutic implication of GSK3
    Xiaohua Li; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Mood disorders are a group of severe mental Illnesses that directly affect over 20% of individuals in the U.S...
  20. Behavioral manifestation and therapeutic implication of GSK3
    Xiaohua Li; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Mood disorders are a group of severe mental Illnesses that directly affect over 20% of individuals in the U.S...
  21. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen McClung; Fiscal Year: 2009
    ..People who have genetic disruptions in circadian gene function are more prone to developing mood disorders such as bipolar disorder or seasonal affective disorder and these disorders are highly co-morbid with ..
  22. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen A McClung; Fiscal Year: 2010
    ..People who have genetic disruptions in circadian gene function are more prone to developing mood disorders such as bipolar disorder or seasonal affective disorder and these disorders are highly co-morbid with ..
  23. Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3
    Eleonore Beurel; Fiscal Year: 2012
    ..which may be particularly important in controlling chronic inflammation that is likely associated with mood disorders. GSK3 also has profound influences in mood disorders, it is inhibited by mood stabilizers and antidepressants, ..
  24. Seasonality of Mood: A Genome-Wide Association Study in the Old Order Amish
    Teodor T Postolache; Fiscal Year: 2010
    ..Some patients with recurrent mood disorders develop full major depression syndromes in the fall or winter, with full remission in spring or summer, a ..
  25. The role of dopaminergic transmission in the development of manic-like behaviors
    SADE MONIQUE SPENCER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): There is a growing body of evidence to suggest that mood disorders, such as bipolar disorder, may be associated with disruptions in circadian rhythms...
  26. Time Course and Potentiation of Fluoxetin Action
    George Battaglia; Fiscal Year: 2004
    ..The long-term goal of the proposed studies is to provide novel therapeutic approaches for the treatment of mood disorders that will work more rapidly and more effectively than the currently available medications...
  27. Time Course and Potentiation of Fluoxetin Action
    LOUIS VAN DE KAR; Fiscal Year: 2003
    ..The long-term goal of the proposed studies is to provide novel therapeutic approaches for the treatment of mood disorders that will work more rapidly and more effectively than the currently available medications...
  28. Time Course and Potentiation of Fluoxetin Action
    LOUIS VAN DE KAR; Fiscal Year: 2002
    ..The long-term goal of the proposed studies is to provide novel therapeutic approaches for the treatment of mood disorders that will work more rapidly and more effectively than the currently available medications...
  29. BDNF-Trk Signaling & Cytokines in Patients with Mood Disorders
    Ghanshyam N Pandey; Fiscal Year: 2010
    ..In our previously funded grant we studied the roles of the PI and the Wnt signaling pathways in patients with mood disorders (MD)...
  30. A Cognitive Neuroscience Framework for Understanding and Treating Mood Disorders
    Moshe Bar; Fiscal Year: 2010
    ..notably for diagnosing and treating emotional disorders such as depression, for better understanding a host of mood disorders such as, attention-deficit, bi-polar and post traumatic stress disorders, for contextualizing adult ..
  31. Metamoodics: Meta-analyses and bioinformatics display of mood disorders genetics
    Peter P Zandi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Mood disorders impose a significant burden on public health...
  32. Neuroimaging of Fatty Acids in Major Depression
    M Elizabeth Sublette; Fiscal Year: 2009
    ..focusing on the role of dietary essential polyunsaturated fatty acids (PUFAs) in the neurobiology of mood disorders and suicide, using positron emission tomography (PET). PROJECT DESIGN: Background...
  33. MENTAL HEALTH RESEARCH TRAINING
    Stanley Watson; Fiscal Year: 2003
    ..postdoctoral fellows in neurobiology and biological psychiatry with particular emphasis on the biology of mood disorders. This program exists in the context of the Mental Health Research Institute (MHRI) of the University of ..
  34. An fMRI study of the brain circuitry of sad emotion in bereavement
    PETER FREED; Fiscal Year: 2009
    ..specializing in the theory and practice of functional magnetic resonance imaging (fMRI) of mood and mood disorders, with a special focus on the relationship of sad emotion to attentional bias in bereavement...
  35. An fMRI study of the brain circuitry of sad emotion in bereavement
    Peter J Freed; Fiscal Year: 2011
    ..specializing in the theory and practice of functional magnetic resonance imaging (fMRI) of mood and mood disorders, with a special focus on the relationship of sad emotion to attentional bias in bereavement...
  36. Neuroimaging of Fatty Acids in Major Depression
    M Elizabeth Sublette; Fiscal Year: 2010
    ..focusing on the role of dietary essential polyunsaturated fatty acids (PUFAs) in the neurobiology of mood disorders and suicide, using positron emission tomography (PET). PROJECT DESIGN: Background...
  37. An fMRI study of the brain circuitry of sad emotion in bereavement
    Peter J Freed; Fiscal Year: 2010
    ..specializing in the theory and practice of functional magnetic resonance imaging (fMRI) of mood and mood disorders, with a special focus on the relationship of sad emotion to attentional bias in bereavement...
  38. MENTAL HEALTH RESEARCH TRAINING
    Stanley Watson; Fiscal Year: 2002
    ..postdoctoral fellows in neurobiology and biological psychiatry with particular emphasis on the biology of mood disorders. This program exists in the context of the Mental Health Research Institute (MHRI) of the University of ..
  39. MENTAL HEALTH RESEARCH TRAINING
    Stanley Watson; Fiscal Year: 2000
    ..postdoctoral fellows in neurobiology and biological psychiatry with particular emphasis on the biology of mood disorders. This program exists in the context of the Mental Health Research Institute (MHRI) of the University of ..
  40. MENTAL HEALTH RESEARCH TRAINING
    Stanley Watson; Fiscal Year: 1999
    ..postdoctoral fellows in neurobiology and biological psychiatry with particular emphasis on the biology of mood disorders. This program exists in the context of the Mental Health Research Institute (MHRI) of the University of ..
  41. MENTAL HEALTH RESEARCH TRAINING
    Stanley Watson; Fiscal Year: 2001
    ..postdoctoral fellows in neurobiology and biological psychiatry with particular emphasis on the biology of mood disorders. This program exists in the context of the Mental Health Research Institute (MHRI) of the University of ..
  42. Effects of lithium on cellular signaling
    Richard S Jope; Fiscal Year: 2011
    The etiology of mood disorders is unknown, a critical problem considering their lifetime prevalence of ~20%...
  43. EFFICACY OF ANTIDEPRESSANTS IN CHRONIC BACK PAIN
    Joseph Atkinson; Fiscal Year: 2009
    ..supports use of noradrenergic antidepressants as analgesics, at lower concentrations than used to treat mood disorders, but only 50% of patients typically achieve satisfactory analgesia, and fewer show improved everyday function...
  44. Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI
    Amit Anand; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): One of the great unsolved mysteries regarding neurobiology of mood disorders is - why do some patients suffer only from episodes of depression (unipolar depression or UD, also known as major ..
  45. Serotonin Reuptake Inhibitors and 5-HT1A Receptors
    George Battaglia; Fiscal Year: 2009
    ..that are involved in various physiological functions and play a role in the etiology and/or treatment of mood disorders. Mood disorders are associated with increased activation of the HPA axis that is normalized by antidepressants...
  46. Suicidal Behavior in Mood Disorders: Genes and Intermediate Phenotypes
    Gustavo Turecki; Fiscal Year: 2009
    ..We have reported candidate gene associations that are independently associated with mood disorders or with suicide attempts...
  47. Suicidal Behavior in Mood Disorders:Genes and Intermediate Phenotypes
    JOSEPH MANN; Fiscal Year: 2009
    ..We have reported candidate gene associations that are independently associated with mood disorders or with suicide attempts...
  48. Suicidal Behavior in Mood Disorders: Genes and Intermediate Phenotypes
    Dan Rujescu; Fiscal Year: 2009
    ..We have reported candidate gene associations that are independently associated with mood disorders or with suicide attempts...
  49. 18F-Mefway for Imaging Mood Disorders and Alzheimer's Disease
    JOGESH MUKHERJEE; Fiscal Year: 2009
    ..Our particular interest is to apply 5HT1A receptor imaging for the study of mood disorders and AD...
  50. 18F-Mefway for Imaging Mood Disorders and Alzheimer's Disease
    JOGESH MUKHERJEE; Fiscal Year: 2007
    ..Our particular interest is to apply 5HT1A receptor imaging for the study of mood disorders and AD...
  51. Development of a Personalized Real-Time Intervention for Bipolar Disorder
    Colin A Depp; Fiscal Year: 2010
    ..provided by applicant): This three-year intervention development proposal is submitted to the NIMH DATR Mood Disorders/Sleep Disorders Program A2-AID and is led by a New Investigator...
  52. Testing a Neurobiological Model of Primary Insomnia
    Daniel Buysse; Fiscal Year: 2007
    ..is a prevalent and chronic health problem associated with substantial morbidity, including increased risk for mood disorders. Despite its prevalence and consequences, little is known about insomnia pathophysiology...
  53. Testing a Neurobiological Model of Primary Insomnia
    Daniel Buysse; Fiscal Year: 2009
    ..is a prevalent and chronic health problem associated with substantial morbidity, including increased risk for mood disorders. Despite its prevalence and consequences, little is known about insomnia pathophysiology...
  54. Program of Excellence in Scientifically Validated Treatments of Mood Disorders
    Mark A Whisman; Fiscal Year: 2010
    ..Based on findings that mood disorders are among the most common and debilitating psychiatric conditions in the United States, and that people with ..
  55. Program of Excellence in Scientifically Validated Treatments of Mood Disorders
    MARK WHISMAN; Fiscal Year: 2009
    ..Based on findings that mood disorders are among the most common and debilitating psychiatric conditions in the United States, and that people with ..
  56. EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITY
    RICHARD JOPE; Fiscal Year: 2001
    ..Understanding lithium's complex mechanisms of action will help reveal causes of mood disorders and development of targeted drugs...
  57. EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITY
    RICHARD JOPE; Fiscal Year: 2002
    ..Understanding lithium's complex mechanisms of action will help reveal causes of mood disorders and development of targeted drugs...
  58. EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITY
    RICHARD JOPE; Fiscal Year: 2004
    ..Understanding lithium's complex mechanisms of action will help reveal causes of mood disorders and development of targeted drugs...
  59. EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITY
    RICHARD JOPE; Fiscal Year: 2003
    ..Understanding lithium's complex mechanisms of action will help reveal causes of mood disorders and development of targeted drugs...
  60. EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITY
    RICHARD JOPE; Fiscal Year: 2000
    ..Understanding lithium's complex mechanisms of action will help reveal causes of mood disorders and development of targeted drugs...
  61. Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for Mania
    Melissa Delbello; Fiscal Year: 2009
    ..trials indicate that omega-3 fatty acid supplementation reduces mood symptom severity in youth and adults with mood disorders. Additionally, postmortem studies reveal significant omega-3 fatty acid deficits in the prefrontal cortex of ..
  62. EFFECTS OF LITHIUM ON CHOLINERGIC ACTIVITY
    RICHARD JOPE; Fiscal Year: 2002
    ..Understanding lithium's complex mechanisms of action will help reveal causes of mood disorders and development of targeted drugs...
  63. Translational Research Evaluating Neurocognitive Memory Processes (TREC-MP)
    Shawn M McClintock; Fiscal Year: 2012
    ..him to become a proficient, independent investigator working at the intersection of neurocognitive function, mood disorders, and neurostimulation interventions...
  64. INTEGRATED TREATMENT FOR COCAINE AND MOOD DISORDERS
    Joy Schmitz; Fiscal Year: 2003
    ..and logical extension of our previous research evaluating treatments that focus simultaneously on cocaine and mood disorders using integrated cognitive behavioral therapy (CBT) and antidepressant therapy...
  65. INTEGRATED TREATMENT FOR COCAINE AND MOOD DISORDERS
    Joy Schmitz; Fiscal Year: 2002
    ..and logical extension of our previous research evaluating treatments that focus simultaneously on cocaine and mood disorders using integrated cognitive behavioral therapy (CBT) and antidepressant therapy...
  66. INTEGRATED TREATMENT FOR COCAINE AND MOOD DISORDERS
    Joy Schmitz; Fiscal Year: 2001
    ..and logical extension of our previous research evaluating treatments that focus simultaneously on cocaine and mood disorders using integrated cognitive behavioral therapy (CBT) and antidepressant therapy...
  67. INTEGRATED TREATMENT FOR COCAINE AND MOOD DISORDERS
    Joy Schmitz; Fiscal Year: 2000
    ..and logical extension of our previous research evaluating treatments that focus simultaneously on cocaine and mood disorders using integrated cognitive behavioral therapy (CBT) and antidepressant therapy...
  68. Translational Research Evaluating Neurocognitive Memory Processes (TREC-MP)
    Shawn M McClintock; Fiscal Year: 2010
    ..him to become a proficient, independent investigator working at the intersection of neurocognitive function, mood disorders, and neurostimulation interventions...
  69. Project 2: Physiological Actions of Novel Antidepressants/Anxiolytics in the Basa
    Donald Rainnie; Fiscal Year: 2009
    ..Abnormal activity of BLA output neurons has been implicated in the etiology of several mood disorders. For example, depressed and anxious individuals show exaggerated amygdala activation in response to negative ..
  70. Web Tool to Disseminate Empirically-based Interventions to Schools
    MELISSA DEROSIER; Fiscal Year: 2009
    ..demonstrated for a wide array of child behavioral and emotional disorders, including ADHD, suicidality, mood disorders, and conduct disorders...
  71. Role of Allopregnanolone in Mediating the Adverse Effects of Psychosocial Stress
    Vasiliki Michopoulos; Fiscal Year: 2010
    The incidence of mood disorders, such as anxiety and depression, in women is twice that in men...
  72. Neuroimaging Markers of Vulnerability to Depression
    Ronald Dahl; Fiscal Year: 2004
    ..against healthy, low-risk' (LR) controls (who have no evidence of having first or second degree relatives with mood disorders) with respect to PET and MRI imaging measures of neurophysiology, serotoninlA receptor binding potential (BP), ..
  73. Neuroimaging Markers of Vulnerability to Depression
    Ronald Dahl; Fiscal Year: 2002
    ..against healthy, low-risk' (LR) controls (who have no evidence of having first or second degree relatives with mood disorders) with respect to PET and MRI imaging measures of neurophysiology, serotoninlA receptor binding potential (BP), ..
  74. Role of Allopregnanolone in Mediating the Adverse Effects of Psychosocial Stress
    Vasiliki Michopoulos; Fiscal Year: 2009
    The incidence of mood disorders, such as anxiety and depression, in women is twice that in men...
  75. Neuroimaging Markers of Vulnerability to Depression
    Ronald Dahl; Fiscal Year: 2001
    ..against healthy, low-risk' (LR) controls (who have no evidence of having first or second degree relatives with mood disorders) with respect to PET and MRI imaging measures of neurophysiology, serotoninlA receptor binding potential (BP), ..
  76. Neuroimaging Markers of Vulnerability to Depression
    Ronald Dahl; Fiscal Year: 2003
    ..against healthy, low-risk' (LR) controls (who have no evidence of having first or second degree relatives with mood disorders) with respect to PET and MRI imaging measures of neurophysiology, serotoninlA receptor binding potential (BP), ..
  77. LOCOMOTOR ACTIVITY RHYTHMS IN PSYCHIATRIC ILLNESS
    Martin Teicher; Fiscal Year: 1992
    ..aim of this application is to obtain accurate, minute-to-minute, activity recordings in patients with major mood disorders and attention-deficit disorder, to develop more precise objective indices of hyperactivity, agitation and ..
  78. IRC FOR THE STUDY OF LATE-LIFE MOOD DISORDERS
    Charles Reynolds; Fiscal Year: 2003
    This application requests support for an Intervention Research Center in Late-Life Mood Disorders (IRC/LLMD) (PAR-98-020) and is the competing continuation of P30 MH52247 (MHCRC for Late-Life Mood Disorders), funded since March 1, 1995...
  79. Melanocortin Signaling in Depression
    Michael Lutter; Fiscal Year: 2010
    ..Disruptions in appetite and body weight regulation are among the most important concerns to patients with mood disorders. Metabolic diseases including obesity, type II diabetes mellitus and heart disease are all much more common in ..
  80. IRC FOR THE STUDY OF LATE-LIFE MOOD DISORDERS
    Charles Reynolds; Fiscal Year: 2000
    This application requests support for an Intervention Research Center in Late-Life Mood Disorders (IRC/LLMD) (PAR-98-020) and is the competing continuation of P30 MH52247 (MHCRC for Late-Life Mood Disorders), funded since March 1, 1995...
  81. IRC FOR THE STUDY OF LATE-LIFE MOOD DISORDERS
    Charles Reynolds; Fiscal Year: 2002
    This application requests support for an Intervention Research Center in Late-Life Mood Disorders (IRC/LLMD) (PAR-98-020) and is the competing continuation of P30 MH52247 (MHCRC for Late-Life Mood Disorders), funded since March 1, 1995...
  82. Melanocortin Signaling in Depression
    Michael Lutter; Fiscal Year: 2009
    ..Disruptions in appetite and body weight regulation are among the most important concerns to patients with mood disorders. Metabolic diseases including obesity, type II diabetes mellitus and heart disease are all much more common in ..
  83. IRC FOR THE STUDY OF LATE-LIFE MOOD DISORDERS
    Charles Reynolds; Fiscal Year: 2002
    This application requests support for an Intervention Research Center in Late-Life Mood Disorders (IRC/LLMD) (PAR-98-020) and is the competing continuation of P30 MH52247 (MHCRC for Late-Life Mood Disorders), funded since March 1, 1995...
  84. IRC FOR THE STUDY OF LATE-LIFE MOOD DISORDERS
    Charles Reynolds; Fiscal Year: 2001
    This application requests support for an Intervention Research Center in Late-Life Mood Disorders (IRC/LLMD) (PAR-98-020) and is the competing continuation of P30 MH52247 (MHCRC for Late-Life Mood Disorders), funded since March 1, 1995...
  85. IRC FOR THE STUDY OF LATE-LIFE MOOD DISORDERS
    Charles Reynolds; Fiscal Year: 2004
    This application requests support for an Intervention Research Center in Late-Life Mood Disorders (IRC/LLMD) (PAR-98-020) and is the competing continuation of P30 MH52247 (MHCRC for Late-Life Mood Disorders), funded since March 1, 1995...
  86. Psychosocial Treatment for Gynecology Patients with Comorbid Depression and Pain
    ELLEN POLESHUCK; Fiscal Year: 2007
    ..foundation for a programmatic line of research developing psychosocial treatments for patients with comorbid mood disorders and chronic pain in primary care, testing them in real world settings, and integrating them into usual ..
  87. Psychosocial Treatment for Gynecology Patients with Comorbid Depression and Pain
    ELLEN POLESHUCK; Fiscal Year: 2009
    ..foundation for a programmatic line of research developing psychosocial treatments for patients with comorbid mood disorders and chronic pain in primary care, testing them in real world settings, and integrating them into usual ..
  88. CLINICAL RESEARCH CENTER FOR STUDY OF MAJOR PSYCHOSES
    Charles Schulz; Fiscal Year: 1992
    ..of the SMH-CRC is the longitudinal study of the pathophysiology and somatic treatments of schizophrenia and mood disorders integrated with informative preclinical research...
  89. The Impact of Sleep Deprivation on Affect Regulation in Young Adults
    PETER FRANZEN; Fiscal Year: 2009
    ..the pathways by which SD alters affect regulation and ultimately address the role of SD in the development of mood disorders. In the proposed research studies, the impact of SD on psychophysiological and neuroimaging indicators of ..