Genomes and Genes
Summary: Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany general medical conditions. (From DSM-IV, 1994)
Publications193 found, 100 shown here
- Pediatric autoimmune neuropsychiatric disorders associated with streptococcus: comparison of diagnosis and treatment in the community and at a specialty clinicVilma Gabbay
Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
Pediatrics 122:273-8. 2008....
- Prevalence of tic disorders: a systematic review and meta-analysisTristan Knight
Royal College of Surgeons, Dublin, Ireland
Pediatr Neurol 47:77-90. 2012This study evaluated the prevalence of tic disorders. MEDLINE and EMBASE databases were searched, using terms specific to Tourette syndrome and tic disorders, for studies of incidence, prevalence, and epidemiology...
- Recent advances in Tourette syndromeMichael Bloch
Department of Psychiatry and the Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
Curr Opin Neurol 24:119-25. 2011..This review considers the recent literature pertaining to the neurobiology, genetics and treatment of Tourette syndrome...
- Comorbidity of tic disorders & ADHD: conceptual and methodological considerationsTobias Banaschewski
Child and Adolescent Psychiatry, University of Goettingen, Goettingen, Germany
Eur Child Adolesc Psychiatry 16:5-14. 2007The causes and pathophysiological mechanisms of the common comorbidity of tic disorders and Attention-deficit/Hyperactivity disorder (TD + ADHD; about 50% of TD, about 20% of ADHD) still remain unclear...
- Children with comorbid attention-deficit-hyperactivity disorder and tic disorder: evidence for additive inhibitory deficits within the motor systemG H Moll
Child and Adolescent Psychiatry Department, , Germany
Ann Neurol 49:393-6. 2001..The findings of a reduced intracortical inhibition as well as a shortened cortical silent period in these comorbid children provide evidence for additive effects at the level of motor system excitability...
- The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: the epidemiological and prevalence studiesMary M Robertson
University College, London, United Kingdom
J Psychosom Res 65:461-72. 2008..GTS is found in all other cultures, although to possibly differing degrees. In all cultures where GTS has been reported, the phenomenology is similar, highlighting the biological underpinnings of the disorder...
- The Autism--Tics, AD/HD and other Comorbidities (A-TAC) telephone interview: convergence with the Child Behavior Checklist (CBCL)Sara Lina Hansson Halleröd
Department of Clinical Sciences, Malmo, Lund University, Sege Park 8A, SE 205 02 Malmo, Sweden
Nord J Psychiatry 64:218-24. 2010....
- Functional brain imaging in Sydenham's chorea and streptococcal tic disordersElvan Caglar Citak
Department of Pediatric Neurology, Gazi University Medical Faculty, Ankara, Turkey
J Child Neurol 19:387-90. 2004..However, the number of cases so far investigated by either SPECT or positron emission tomography is still too limited to draw any firm conclusions...
- European clinical guidelines for Tourette syndrome and other tic disorders. Part I: assessmentDanielle C Cath
Department of Clinical and Health Psychology, Utrecht University Altrecht Academic Anxiety Outpatient Services, PO Box 80 140, 3508 TC Utrecht, The Netherlands
Eur Child Adolesc Psychiatry 20:155-71. 2011..Detailed clinical assessment guidelines of tic disorders and their comorbidities in both children and adults are presented...
- Psychiatric telephone interview with parents for screening of childhood autism - tics, attention-deficit hyperactivity disorder and other comorbidities (A-TAC): preliminary reliability and validitySara Lina Hansson
Department of Child and Adolescent Psychiatry, Goteborg University, Sweden
Br J Psychiatry 187:262-7. 2005..Reliable, valid and easily administered screening instruments would greatly facilitate large-scale neuropsychiatric research...
- European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatmentVeit Roessner
Department of Child and Adolescent Psychiatry, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
Eur Child Adolesc Psychiatry 20:173-96. 2011..and EMBASE search for all studies that document the effect of pharmacological treatment of TS and other tic disorders between 1970 and November 2010...
- Tic disorders: what happens in the basal ganglia?Maya Bronfeld
Bar Ilan University, Ramat Gan, Israel
Neuroscientist 19:101-8. 2013..This line of research provides a mechanistic description of the underlying neurophysiology of motor tics and may supply the much needed infrastructure for methodical hypothesis-driven studies of novel clinical treatments...
- Prevalence of tic disorders among primary school students in the city of Pavia, ItalyG Lanzi
Department of Child Neurology and Psychiatry, C Mondino Foundation, University of Pavia, Via Palestro 3, 27100 Pavia, Italy
Arch Dis Child 89:45-7. 2004The prevalence of tic disorders in children varies from 1% to 29% depending on the characteristics of the study population, the diagnostic criteria, and the study design and methods.
- Relative contribution of attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and tic severity to social and behavioral problems in tic disordersPieter J Hoekstra
Child and Adolescent Psychiatry Center, Groningen, The Netherlands
J Dev Behav Pediatr 25:272-9. 2004..There was no significant correlation between tic severity and ADHD severity. Thus, in patients with a tic disorder, the presence and severity of ADHD are the main predictors of associated behavioral and social problems...
- Tourette's syndrome in Taiwan: an epidemiological study of tic disorders in an elementary school at Taipei CountyHuei Shyong Wang
Division of Pediatric Neurology, Chang Gung Children s Hospital, Chang Gung University, Taiwan
Brain Dev 25:S29-31. 2003..The familial rate of Tourette's syndrome was 27%. We also found that another 98 children had transient tic disorders. For 73% of patients with mild tics, understanding and acceptance from family, teachers, and friends are the ..
- European clinical guidelines for Tourette syndrome and other tic disorders. Part IV: deep brain stimulationKirsten R Müller-Vahl
Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
Eur Child Adolesc Psychiatry 20:209-17. 2011..It is highly recommended to perform DBS in the context of controlled trials...
- Childhood-onset obsessive-compulsive disorder and tic disorders: case report and literature reviewLisa A Snider
Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Child Adolesc Psychopharmacol 13:S81-8. 2003A subgroup of childhood-onset obsessive-compulsive disorder (OCD) and tic disorders has been found to have a postinfectious autoimmune-mediated etiology...
- Tic disorders and obsessive-compulsive disorder: is autoimmunity involved?Pieter J Hoekstra
Child and Adolescent Psychiatry Centre, Groningen, The Netherlands
Int Rev Psychiatry 17:497-502. 2005The precise cause of tic disorders and paediatric obsessive-compulsive disorder (OCD) is unknown...
- Tourette syndrome and other tic disorders in a total population of children: clinical assessment and backgroundNajah Khalifa
Department of Neuroscience, Child and Adolescent Psychiatry, University Hospital, Uppsala, Sweden
Acta Paediatr 94:1608-14. 2005To describe the symptoms, onset, heredity, pre-/perinatal events and socio-economic status in Tourette syndrome (TS) and other tic disorders.
- Prevalence and clinical correlates of tic disorders in a community sample of school-age childrenJanne Tabori Kraft
Psychiatric Hospital of Children and Adolescents, Aarhus University Hospital, Risskov, Denmark
Eur Child Adolesc Psychiatry 21:5-13. 2012..13-15 years of age, parents of the children who screened positive for tics were interviewed in detail about tic disorders. The prevalence of Tourette Syndrome (TS) was 0.6 and 0.6% of chronic motor tics (CMT)...
- Tourette syndrome and other tic disordersHarvey S Singer
Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore 21287, USA
Handb Clin Neurol 100:641-57. 2011b>Tic disorders, including Tourette syndrome, are an intriguing group of paroxysmal movement abnormalities that begin in childhood, have a fluctuating course, are capable of causing psychosocial and physical problems, and often improve by ..
- Tic disorders: administrative prevalence and co-occurrence with attention-deficit/hyperactivity disorder in a German community sampleM Schlander
Institute for Innovation and Valuation in Health Care InnoVal HC, An der Ringkirche 4, 65197 Wiesbaden, Germany
Eur Psychiatry 26:370-4. 2011..Existing data on the co-occurrence of tic disorders, Tourette Syndrome (TS), and ADHD are largely derived from small-scale studies in selected samples and ..
- Tics and problem behaviors in schoolchildren: prevalence, characterization, and associationsLisa A Snider
Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1255, USA
Pediatrics 110:331-6. 2002b>Tic disorders are the most common movement disorder diagnosed in children and have symptoms that fluctuate in frequency and intensity over time...
- Disruptive behavior problems in a community sample of children with tic disordersLawrence Scahill
Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
Adv Neurol 99:184-90. 2006
- Psychopharmacology of tic disorders in children and adolescentsMadeline A Chadehumbe
Division of Pediatric Neurology, Michigan State University, Helen DeVos Children s Hospital, Grand Rapids, MI 49503, USA
Pediatr Clin North Am 58:259-72, xiii. 2011..This article reviews medications used to treat tic disorders in children and adolescents.
- Cognitive-behavioral therapy for childhood repetitive behavior disorders: tic disorders and trichotillomaniaChristopher A Flessner
Division of Child and Family Psychiatry, Rhode Island Hospital, Warren Alpert School of Medicine at Brown University, Providence, RI 02903, USA
Child Adolesc Psychiatr Clin N Am 20:319-28. 2011..Because tic disorders and trichotillomania are the most often studied and most debilitating of these conditions, this article ..
- Prevalence of tic disorders among schoolchildren in Warsaw, PolandP Stefanoff
Dept of Epidemiology, National Institute of Hygiene, 24, Chocimska Str, 00 791 Warsaw, Poland
Eur Child Adolesc Psychiatry 17:171-8. 2008To estimate the prevalence and to describe clinical characteristics of tic disorders in 12-15 year old Warsaw schoolchildren.
- Public health significance of tic disorders in children and adolescentsLawrence Scahill
Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
Adv Neurol 96:240-8. 2005In conclusion, data from community surveys suggest that tic disorders, including TS, exist on a spectrum from transient to persistent, multiple motor, and vocal tics that interfere with activities of daily living...
- Tics moderate treatment outcome with sertraline but not cognitive-behavior therapy in pediatric obsessive-compulsive disorderJohn S March
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
Biol Psychiatry 61:344-7. 2007..The presence of a comorbid tic disorder may predict a poorer outcome in the acute treatment of pediatric obsessive-compulsive disorder (OCD)...
- Comparative study of the behavioral and neuropsychologic characteristics of tic disorder with or without attention-deficit hyperactivity disorder (ADHD)M S Shin
Department of Child Psychiatry, Seoul National University College of Medicine, Korea
J Child Neurol 16:719-26. 2001..The tic disorder with ADHD group might represent a true comorbidity of the two disorders...
- Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 casesS E Swedo
Section on Behavioral Pediatrics, NIMH, Rockville Pike, Bethesda, MD 20892 1381, USA
Am J Psychiatry 155:264-71. 1998..the clinical characteristics of a novel group of patients with obsessive-compulsive disorder (OCD) and tic disorders, designated as pediatric autoimmune neuropsychiatric disorders associated with streptococcal (group A beta-..
- An open-label study of the efficacy and tolerability of aripiprazole for children and adolescents with tic disordersHanik K Yoo
Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
J Clin Psychiatry 68:1088-93. 2007..and tolerability of aripiprazole, an atypical antipsychotic with dual agonist and antagonist actions toward dopaminergic imbalance and partial serotonin-2A receptor antagonism, for treating children and adolescents with tic disorders.
- Treatment of children and adolescents with tics and Tourette syndromeDonald Gilbert
Movement Disorders and Tourette Syndrome Clinics, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
J Child Neurol 21:690-700. 2006..This review focuses primarily on the diagnosis and medical treatment of tics in children and adolescents with Tourette syndrome...
- An open-label, prospective study of guanfacine in children with ADHD and tic disordersVitharon Boon-Yasidhi
Division of Child Psychiatry, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand
J Med Assoc Thai 88:S156-62. 2005To evaluate the efficacy and safety of guanfacine in children with attention-deficit hyperactivity disorder (ADHD) and tic disorders.
- Atomoxetine treatment in children and adolescents with ADHD and comorbid tic disordersA J Allen
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Neurology 65:1941-9. 2005To test the hypothesis that atomoxetine does not significantly worsen tic severity relative to placebo in children and adolescents with attention deficit/hyperactivity disorder (ADHD) and comorbid tic disorders.
- Atomoxetine use associated with onset of a motor ticMarcialee Ledbetter
Department of Psychiatry and Pediatrics, University of Oklahoma Tulsa, Tulsa, Oklahoma 74135, USA
J Child Adolesc Psychopharmacol 15:331-3. 2005..with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for Tourette's Disorder and other tic disorders. Stimulant medications and bupropion have been associated with the onset or exacerbation of a tic disorder...
- Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndromeMichael H Bloch
Yale Child Study Center, and General Clinical Research Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
Arch Pediatr Adolesc Med 160:65-9. 2006..One half to two thirds of children with TS experience a reduction or complete resolution of tic symptoms during adolescence. At least one third of adults with TS have comorbid obsessive-compulsive disorder (OCD)...
- Quetiapine for chronic motor tic disorderDrew Barzman
Am J Psychiatry 161:1307. 2004
- Psychopathology in a Swedish population of school children with tic disordersNajah Khalifa
Department of Neuroscience, Uppsala University, Uppsala, Sweden
J Am Acad Child Adolesc Psychiatry 45:1346-53. 2006To examine patterns of psychiatric comorbid disorders and associated problems in a school population of children with tic disorders.
- The behavioral spectrum of tic disorders: a community-based studyR Kurlan
Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8673, USA
Neurology 59:414-20. 2002Tourette syndrome (TS) and related tic disorders are commonly associated with obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD)...
- [Transcranial magnetic stimulation in child and adolescent psychiatry: excitability of the motor system in tic disorders and/or attention deficit hyperactivity disorders]G H Moll
Z Kinder Jugendpsychiatr Psychother 29:312-23. 2001....
- Drug and non-drug treatments of children with ADHD and tic disordersYann Poncin
Child Study Center, Yale University, P O Box 207900, New Haven, CT, 06520, USA
Eur Child Adolesc Psychiatry 16:78-88. 2007To review the treatment of ADHD in children with chronic tic disorders.
- Impact of tic disorders on ADHD outcome across the life cycle: findings from a large group of adults with and without ADHDT J Spencer
Pediatric Psychopharmacology Unit (WACC 725, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114-3117, USA
Am J Psychiatry 158:611-7. 2001OBJECTIVE: The impact of tic disorders on the outcome of attention deficit hyperactivity disorder (ADHD) remains a subject of high scientific and clinical interest...
- A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorderL Scahill
Yale Child Study Center, New Haven, CT 06520, USA
Am J Psychiatry 158:1067-74. 2001This study evaluated the efficacy and safety of guanfacine in treating children with tic disorders and attention deficit hyperactivity disorder (ADHD).
- Color perception deficits in co-existing attention-deficit/hyperactivity disorder and chronic tic disordersV Roessner
Department of Child and Adolescent Psychiatry, University of Goettingen, Goettingen, Germany
J Neural Transm 115:235-9. 2008..of blue-yellow stimuli, is impaired in attention-deficit/hyperactivity disorder (ADHD) as well as in chronic tic disorders (CTD)...
- Development of tics in a thirteen-year-old male following atomoxetine useJessica Sears
Pediatric Neurology, Department of Child Health, University of Missouri Columbia, Columbia, MO 65212, USA
CNS Spectr 13:301-3. 2008..We present a unique case of a patient, without any prior history of a movement disorder, who developed tics following a single dose of atomoxetine that did not improve until interventional therapy was initiated...
- Randomized double-blind multicentre placebo-controlled clinical trial of the clonidine adhesive patch for the treatment of tic disordersYa song Du
Department of Child and Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University, Shanghai, China
Aust N Z J Psychiatry 42:807-13. 2008The aim of the present study was to evaluate the therapeutic effectiveness and safety of the clonidine adhesive patch in treating tic disorders.
- Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disordersMichael H Bloch
Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
J Am Acad Child Adolesc Psychiatry 48:884-93. 2009..We sought to determine the relative efficacy of different medications in treating ADHD and tic symptoms in children with both Tourette's syndrome and ADHD...
- Sleep patterns in children with attention-deficit/hyperactivity disorder, tic disorder, and comorbidityRoumen Kirov
Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
J Child Psychol Psychiatry 48:561-70. 2007....
- Tic disorders: from pathophysiology to treatmentLiborio Rampello
Department of Neurosciences, University of Catania, Neurology, Azienda Policlinico, Via S Sofia, 78, 95123, Catania, Italy
J Neurol 253:1-15. 2006b>Tic disorders are stereotypic behaviours,more frequent than once believed, and therefore likely to be encountered by primary care physicians...
- Psychopathological profile in children with chronic tic disorder and co-existing ADHD: additive effectsVeit Roessner
Department of Child and Adolescent Psychiatry, University of Goettingen, Germany, Von Siebold Strasse 5, 37075 Goettingen, Germany
J Abnorm Child Psychol 35:79-85. 2007The nature of the co-occurrence of chronic tic disorders (CTD) and attention deficit hyperactivity disorder (ADHD) is unclear. Especially in the field of psychopathology, the relationship of CTD and ADHD remains to be clarified...
- Stress fracture of the peroneal bone secondary to a complex ticCarlo Fusco
Child Neurology Unit, Arcispedale Santa Maria Nuova, Viale Risorgimento, 80 42100 Reggio Emilia, Italy
Brain Dev 28:52-4. 2006..The clinical history was strongly suggestive of obsessive-compulsive disorder and Tourette syndrome with associated simple and complex motor tics. Radiographic follow-up showed spontaneous resolution of the fractures...
- Effectiveness and safety of risperidone for children and adolescents with chronic tic or tourette disorders in KoreaBoong Nyun Kim
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
J Child Adolesc Psychopharmacol 15:318-24. 2005....
- The symptomatology of tic disorders and concomitant sleep habits in childrenJ Młodzikowska-Albrecht
Chair and Department of Developmental Neurology, Poznan University of Medical Sciences, Poland
Adv Med Sci 52:212-4. 2007The aim of study was to analyze the clinical symptoms of tic disorders (TG) and sleep habits in children. The sleep habits were compared with those of a control group (CG).
- Attentional functions in children and adolescents with attention-deficit/hyperactivity disorder with and without comorbid tic disorderE Greimel
Child Neuropsychology Section, Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of the RWTH Aachen, Aachen, Germany
J Neural Transm 115:191-200. 2008..Alternatively, compensatory neural mechanisms of TD patients may result in a better neuropsychological performance of comorbid patients relative to patients suffering from pure ADHD...
- Executive functions in children with chronic tic disorders with/without ADHD: new insightsVeit Roessner
Dept of Child and Adolescent Psychiatry Psychotherapy, University of Goettingen, Von Siebold Str 5, 37075, Goettingen, Germany
Eur Child Adolesc Psychiatry 16:36-44. 2007In Chronic Tic Disorders (CTD) associated Attention Deficit Hyperactivity Disorder (ADHD) is very common. Hence, it is important to clarify how both conditions are related to cognitive dysfunctions in patients with CTD+ADHD comorbidity...
- Tic disorders: some key issues for DSM-VJohn T Walkup
Department of Psychiatry, Division of Child and Adolescent Psychiatry, Weill Cornell Medical College, New York, New York 10065, USA
Depress Anxiety 27:600-10. 2010This study provides a focused review of issues that are relevant to the nosology of the tic disorders and presents preliminary recommendations to be considered for DSM-V...
- Quetiapine in the treatment of tic disorderAllison E Little
Ann Pharmacother 40:1472. 2006
- First-onset tics in patients with attention-deficit-hyperactivity disorder: impact of stimulantsVeit Roessner
Department of Child and Adolescent Psychiatry, University of Goettingen, Germany
Dev Med Child Neurol 48:616-21. 2006..The results of high quality studies, in addition to specialized studies with methodological limitations, suggest that stimulants are the criterion standard for the safe and successful treatment of ADHD...
- A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorderM H Bloch
Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
Mol Psychiatry 11:622-32. 2006..Patients with comorbid tics are likely to have a differential benefit to antipsychotic augmentation...
- Co-existence of tic disorders and attention-deficit/hyperactivity disorder-recent advances in understanding and treatmentAribert Rothenberger
Eur Child Adolesc Psychiatry 16:1-4. 2007In daily clinical practice of child psychiatry tic disorders (TD) and attention-deficit/hyperactivity disorder (ADHD) as well as their co-existence are common and need careful evidence-based approaches in differential diagnostics and ..
- Open label aripiprazole in the treatment of youth with tic disordersTanya K Murphy
Department of Pediatrics and Psychiatry, University of South Florida, St Petersburg, FL 33701, USA
J Child Adolesc Psychopharmacol 19:441-7. 2009Primarily safe and efficacious treatments for chronic tic disorders are needed. Also needed are such treatments that target co-morbid conditions...
- Efficacy of botulinum toxin in severe Tourette syndrome with dystonic tics involving the neckMaria Aguirregomozcorta
Neurology Department, Hospital Dr Josep Trueta, Girona, Spain
Parkinsonism Relat Disord 14:443-5. 2008....
- European clinical guidelines for Tourette syndrome and other tic disorders. Part III: behavioural and psychosocial interventionsCara Verdellen
HSK Group Expertise Centre Tics, Hambakenwetering 5B, 5231 DD Den Bosch, The Netherlands
Eur Child Adolesc Psychiatry 20:197-207. 2011..recommendations for the behavioural and psychosocial interventions (BPI) of children and adolescents with tic disorders prepared by a working group of the European Society for the Study of Tourette Syndrome (ESSTS)...
- Tic reduction with risperidone versus pimozide in a randomized, double-blind, crossover trialDonald L Gilbert
Department of Neurology, Cincinnati Children s Hospital Medical Center, Division of Developmental and Behavioral Sciences Children s Mercy Hospital, Kansas City, KS, USA
J Am Acad Child Adolesc Psychiatry 43:206-14. 2004To compare the tic suppression, electrocardiogram (ECG) changes, weight gain, and side effect profiles of pimozide versus risperidone in children and adolescents with tic disorders.
- Tic reduction with pergolide in a randomized controlled trial in childrenD L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Neurology 60:606-11. 2003To determine whether pergolide, a mixed D1/D2/D3 dopamine agonist, is efficacious and safe in the treatment of children with chronic tic disorders and Tourette syndrome.
- Tics and psychiatric comorbidity in children and adolescentsKenneth D Gadow
Department of Psychiatry and Behavioral Science, State University of New York at Stony Brook, 11794 8790, USA
Dev Med Child Neurol 44:330-8. 2002..a community-based sample show many similarities with studies of clinically referred samples suggesting that teacher-completed ratings of DSM-IV symptoms may be a useful methodology for investigating the phenomenology of tic disorders.
- A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorderThomas Spencer
Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
Arch Gen Psychiatry 59:649-56. 2002Currently, there is no consensus on the best therapeutic approach to chronic tic disorders and comorbid attention-deficit/hyperactivity disorder (ADHD)...
- Lack of effect of intravenous immunoglobulins on tics: a double-blind placebo-controlled studyPieter J Hoekstra
Child and Adolescent Psychiatry Center, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
J Clin Psychiatry 65:537-42. 2004..No data are available on the effectiveness of intravenous immunoglobulins (IVIG) on tic severity in unselected tic disorder patients...
- Prospective, longitudinal study of tic, obsessive-compulsive, and attention-deficit/hyperactivity disorders in an epidemiological sampleB S Peterson
Yale Child Study Center, Yale University School of Medicine, New Haven CT 06520, USA
J Am Acad Child Adolesc Psychiatry 40:685-95. 2001..These findings are in general consistent with those from family studies, and they help to define the natural history, comorbid illnesses, and interrelatedness of these conditions...
- Tic disorders: when habit forming neural systems form habits of their own?J F Leckman
Child Study Center, Department of Pediatrics, Yale University, New Haven, CT 06520 7900, USA
Zhonghua Yi Xue Za Zhi (Taipei) 64:669-92. 2001..It is likely that the research paradigms utilized in these studies and many of the empirical findings resulting from them, will be relevant to other disorders of childhood onset and to our understanding of normal development...
- Comorbidity in ADHD-children: effects of coexisting conduct disorder or tic disorder on event-related brain potentials in an auditory selective-attention taskA Rothenberger
Central Institute of Mental Health, Child and Adolescent Psychiatry, Mannheim, Germany
Eur Arch Psychiatry Clin Neurosci 250:101-10. 2000..Nd and P300 amplitudes showed no significant group differences. It may be assumed that neurodynamic sufficiency in ADHD-only and ADHD + Tic children seems to be similarly impaired while there might be a greater deficit in ADHD + CD...
- Prevalence of tic disorders and Tourette syndrome in a Swedish school populationNajah Khalifa
Department of Women s and Children s Health, University Hospital, Uppsala, Sweden
Dev Med Child Neurol 45:315-9. 2003The aim of the study was to find the epidemiological distribution of tic disorders and Tourette syndrome (TS) in Swedish school children aged 7 to 15 years...
- Association between streptococcal infection and obsessive-compulsive disorder, Tourette's syndrome, and tic disorderLoren K Mell
Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
Pediatrics 116:56-60. 2005....
- Obsessive-compulsive disorder in youth with and without a chronic tic disorderEric A Storch
Department of Psychiatry, University of Florida, Gainesville, Florida 32610, USA
Depress Anxiety 25:761-7. 2008..Implications of these findings on clinical presentation and treatment efficacy are highlighted...
- Severe obsessive-compulsive disorder with and without comorbid hair pulling: comparisons and clinical implicationsS Evelyn Stewart
McLean Hospital, Boston, Mass, USA
J Clin Psychiatry 66:864-9. 2005..This study determined the prevalence of hair pulling in an inpatient obsessive-compulsive disorder (OCD) population and compared clinical characteristics and treatment response between subgroups with and without comorbid hair pulling...
- The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family studyM A Grados
Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, USA
Biol Psychiatry 50:559-65. 2001BACKGROUND: Obsessive-compulsive disorder (OCD) and tic disorders have phenomenological and familial-genetic overlaps...
- Tic disorders in the adolescentSamuel Kuperman
Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1057, USA
Adolesc Med 13:537-51. 2002This chapter addresses the multidimensional nature of tic disorders. The several major dimensions include (1) duration of symptoms (from less than 1 year to lifelong); (2) intensity of symptoms (from mild to severe); (3) frequency of ..
- Adult-onset tic disordersValsamma Eapen
Department of Psychiatry and Behavioural Sciences, Royal Free and University College, London Medical School, London, United Kingdom
Mov Disord 17:735-40. 2002..In comparison with DSM-classified, younger-onset Gilles de la Tourette syndrome, adult-onset tic disorders are more often associated with severe symptoms, greater social morbidity, a potential trigger event, increased ..
- Phenomenology of tics and natural history of tic disordersJames F Leckman
Child Study Center, Sterling Hall of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
Adv Neurol 99:1-16. 2006
- Premonitory Urge for Tics Scale (PUTS): initial psychometric results and examination of the premonitory urge phenomenon in youths with Tic disordersDouglas W Woods
Department of Psychology, University of Wisconsin Milwaukee, 53201, USA
J Dev Behav Pediatr 26:397-403. 2005..Likewise, significant correlations found between the YGTSS subscales, CBCL subscales, CYBOCS, and the PUTS did not emerge in this younger age group. The clinical and theoretical implications of these findings are discussed...
- Tic disorders: neural circuits, neurochemistry, and neuroimmunologyKendra Harris
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Child Neurol 21:678-89. 2006The neuroanatomy and neurochemistry underlying tic disorders are thought to involve corticostriatothalamocortical circuits and dysregulation of their component neurotransmitter systems...
- Tourette syndrome and tic disorders: a decade of progressJames E Swain
Child Study Center of Yale University, New Haven, CT, USA
J Am Acad Child Adolesc Psychiatry 46:947-68. 2007..This is a review of progress made in the understanding of Tourette syndrome (TS) during the past decade including models of pathogenesis, state-of-the-art assessment techniques, and treatment...
- The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorderDavide Martino
Department of Neurological and Psychiatric Sciences, University of Bari, Italy
J Psychosom Res 67:547-57. 2009..Given the relevance of this topic for general pediatric health, additional research efforts to solve all the pending issues and the hottest points of debate are warranted...
- Sensory phenomena in obsessive-compulsive disorder and tic disorders: a review of the literatureHelena S Prado
Department of Psychiatry at the University of São Paulo Medical School, Sao Paulo, Brazil
CNS Spectr 13:425-32. 2008..This lack of consensus may hinder the understanding of study results and prevents the possibility of including them in the search for etiological factors associated with OCD and TS...
- A family study of early-onset obsessive-compulsive disorderMaria Conceição do Rosario-Campos
Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
Am J Med Genet B Neuropsychiatr Genet 136:92-7. 2005..Childhood onset OCD is a highly familial disorder. Some early-onset cases may represent a valid subgroup, with higher genetic loading and shared vulnerability with chronic tic disorders.
- Combined treatment with haloperidol and trazodone in patients with tic disordersL Saccomani
Child Neuropsychiatry, DSNV, G Gaslini Institute, University of Genova, Italy
J Child Adolesc Psychopharmacol 10:307-10. 2000..001) between the baseline and endpoint treatment conditions. This approach significantly reduces clinical symptoms, with the advantage of a lower dose of haloperidol than usual, with no side effects reported by the patients...
- Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with ticsC Cruz
Departamento de Genética Psiquiátrica, Instituto Mexicano de Psiquiatría Calzada Mexico Xochimilco, San Lorenzo Huipulco, Mexico D F
Neurosci Lett 231:1-4. 1997..66, P = 0.03). Our study suggests that the seven-repeat allele of the DRD4 gene could be a factor in the phenotypic variance of tics among OCD individuals...
- Group A streptococcal infections and tic disorders in an Italian pediatric populationF Cardona
Department of Developmental Neuropsychiatry, University La Sapienza and Istituto Superiore di Sanità, Rome, Italy
J Pediatr 138:71-5. 2001The relationship between childhood tic disorders and group A streptococcal (GAS) infections has been recently investigated by several research groups, but no systematic evaluation of laboratory indicators of GAS infections has been ..
- Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorderD Mataix-Cols
Department of Psychiatry, Universitat de Barcelona, Spain
Am J Psychiatry 156:1409-16. 1999..Recent factor analytic studies have identified meaningful symptom dimensions that may be related to response to serotonin reuptake inhibitors and other treatments...
- Prospective longitudinal study of children with tic disorders and/or obsessive-compulsive disorder: relationship of symptom exacerbations to newly acquired streptococcal infectionsFeng Luo
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA
Pediatrics 113:e578-85. 2004..It has been proposed that infection by group A beta-hemolytic streptococci (GABHS) can trigger acute symptom exacerbations among patients with Tourette's syndrome (TS) or obsessive-compulsive disorder (OCD), via autoimmune mechanisms...
- Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorderDiane E Dickel
Institute of Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Biol Psychiatry 61:322-9. 2007..Early-onset OCD is a more familial form of the disorder...
- Tics and Tourette syndrome in autism spectrum disordersRoberto Canitano
University Hospital of Siena, Italy
Autism 11:19-28. 2007Autism spectrum disorders (ASDs) are more frequently associated with tic disorders than expected by chance. Variable rates of comorbidity have been reported and common genetic and neurobiological factors are probably involved...
- Tics and Tourette's syndrome in childhoodSamuel Kuperman
Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Semin Pediatr Neurol 10:35-40. 2003..This review describes these dimensions and their relationships to the current diagnostic scheme for tic disorders.
- Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary studyIvana Kawikova
Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06520, USA
Biol Psychiatry 61:273-8. 2007..We also postulated that group A beta hemolytic streptococcal infections could promote autoimmune responses by releasing exotoxins (streptococcal pyrogenic exotoxins [SPE])...
- [Neuroimaging data of ADHD, tic-disorder and obsessive-compulsive-disorder in children and adolescents]Timo D Vloet
Klinik fur Kinder und Jugendpsychiatrie und psychotherapie, Universitatsklinikum Aachen, Neuenhofer Weg 21, DE 52074 Aachen
Z Kinder Jugendpsychiatr Psychother 34:343-55. 2006..Since the majority of the studies reviewed are characterised by small and heterogeneous samples, and since the studies differ in their methods, comparability is limited and general conclusions can not be drawn...
- [From tics to obsessive-compulsive disorders in children: a subsequent risk now recognized]P Fourneret
Arch Pediatr 10:464-5. 2003
- Fragile X syndrome associated with tic disordersSusanne A Schneider
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
Mov Disord 23:1108-12. 2008..We suggest considering fragile X syndrome in GTS complicated by co-morbidity with late onset of atypical tics, in particular when learning disability and dysmorphic features are present...
- Gilles de la Tourette's syndromeKia Faridi
Department of Psychiatry, McGill University, Montreal, QC, Canada
Can J Neurol Sci 30:S64-71. 2003..For more severe cases, medications such as tetrabenazine and neuroleptics may be helpful. Treatment of co-morbidities needs to be considered, as these may result in moredisability than the tics themselves...
- Autoimmune neuropsychiatric disorders associated with streptococcal infection: Sydenham chorea, PANDAS, and PANDAS variantsPiero Pavone
Department of Pediatrics, Division of Clinical Pediatrics, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
J Child Neurol 21:727-36. 2006..In this review, we summarize this complex and rapidly evolving area of clinical research...
- [Gilles de la Tourette syndrome: a clinical study on 58 cases]C H Fen
, , Faculdade de Medicina, , , SP, Brasil
Arq Neuropsiquiatr 59:729-32. 2001..Associated manifestations, such as attention deficit, hyperactivity disorder and obsessive-compulsive disorder were present in 25.8% and 39.6%, respectively. Sensory phenomena were present in 54.8% of the patients...
- Locus Coeruleus-Norepinephrine System Regulation of Prepulse InhibitionVaishali P Bakshi; Fiscal Year: 2010..filtering systems represents a core endophenotype manifested in schizophrenia, obsessive compulsive disorder, tic disorders, and possibly attention deficit hyperactivity disorder and post traumatic stress disorder...
- Quality of life, Comorbidities, and Health Service Utilization in Youth with TicMD MURPHY; Fiscal Year: 2011Among neuropsychiatric disorders, tic disorders including Tourette syndrome, affects a large number of children: approximately 1% of those in the general population and up to 20% of students in Exceptional Student Educational classrooms...
- Computerized Self Administered Behavioral Intervention for Tics in ChildrenSuzanne Mouton-Odum; Fiscal Year: 2012..the feasibility of an innovative computer-based treatment-delivery product for children with Chronic Tic Disorders (CTD;including Tourette's Disorder) and their families...
- TESTING THE PHASIC DOPAMINE RELEASE HYPOTHESIS IN TOURETTE SYNDROME: PILOTTAMARA G HERSHEY; Fiscal Year: 2013..in their life, and about 3% of all children have a chronic tic disorder such as Tourette syndrome (TS), making tic disorders a subject of substantial public health interest...
- Linking Brain and Behavior in Chronic Tic DisorderSandra K Loo; Fiscal Year: 2013..empirically supported behavioral treatments such as Habit Reversal Training (HRT) for individuals with Chronic Tic Disorders (CTDs), including those with Tourette's Syndrome...
- Next generation risk variant discovery in a highly penetrant OCD subtypeErika L Nurmi; Fiscal Year: 2013..details an approach to mapping risk for a strongly genetic subtype of obsessive compulsive (OCD) and comorbid tic disorders by generating and analyzing whole-exome sequence in select families to identify risk alleles...
- Neural Correlates of Tourette SyndromeAbhishek Prasad; Fiscal Year: 2011..provided by applicant): Tourette syndrome (TS) is in a class of neuropsychiatric disorders referred to as "tic disorders" which are characterized by involuntary, often repetitive behaviors that can be disruptive, inappropriate, and ..
- Clinical and Research Training Curriculum in Behavioral TreatmentsDouglas W Woods; Fiscal Year: 2012..structure as well as existing faculty clinical-research strengths in habit reversal training (HRT) for tic disorders (TD) and trichotillomania (TTM) and behavioral activation (BA) for depression...
- Impact of TicsJonathan W Mink; Fiscal Year: 2011Project Summary/Abstract Tourette's syndrome (TS) is a childhood-onset tic disorders that is associated with a spectrum of co-occurring neuropsychiatric problems (particularly ADHD and OCD) and that has been found to be much more ..
- Identifying de novo mutations causing OCD in trios by whole exome sequencingGerald Nestadt; Fiscal Year: 2013..for characteristics that are shared between unrelated cases with causal variants in the same gene and also by looking for genetic similarities within clearly defined clinical subgroups of patients, such as those with tic disorders.
- RTMS for Adults with Severe Tourette SyndromeJames Leckman; Fiscal Year: 2009..neurocircuitry has been used to guide the design of focal brain stimulation strategies to study and treat tic disorders. Transcranial magnetic stimulation (TMS) has been used to investigate TS for the past decade and repetitive ..
- IMPROVING THE OUTCOME OF PATIENTS WITH OCDHelen Simpson; Fiscal Year: 2004..and cognitive-behavioral therapy using exposure and ritual prevention (EX/RP), and specialized training in tic disorders); 2) acquire the skills and experiences needed by an independent clinical researcher (by coursework/..
- METHYLPHENIDATE TREATMENT OF ADHD IN CHILDREN WITH TSKenneth Gadow; Fiscal Year: 2004..To evaluate the impact of tic severity and comorbid internalizing and externalizing symptoms on clinical outcome, children with ADHD/+tics will be compared with an additional sample of children with ADHD/-tics at ages 11 and 16 years. ..
- A Prospective Longitudinal Study of PANDASJames Leckman; Fiscal Year: 2005b>Tic disorders, obsessive-compulsive disorder (OCD), and related conditions are prevalent disorders affecting as many as 0.3-3 percent of the pediatric population...
- PANDAS and Strep Infection: Are they Linked?Roger Kurlan; Fiscal Year: 2004..Disproving the PANDAS hypothesis would prevent the use of expensive and potentially dangerous therapies (e.g., plasma exchange, immune globulin, antibiotics) that have been proposed for PANDAS patients. ..
- Treating Agitation/Psychosis in Dementia/ParkinsonismRoger Kurlan; Fiscal Year: 2004..This study will provide important information regarding the optimal treatment of psychosis and agitation for patients with the commonly encountered combination of primary dementia and parkinsonism. ..
- RUPP-PI Program at Yale UniversityLawrence Scahill; Fiscal Year: 2006..Furthermore, this five-site network has established reliability on several measures that are relevant to the conduct of clinical trials in children with PDD. ..
- Behavior Therapy for Adults with Tourette SyndromeLawrence Scahill; Fiscal Year: 2009..The Informatics group at Yale University will provide data management services. ..
- Pharmacogenetics in Tourette SyndromHarvey Singer; Fiscal Year: 2004..The identification of genetic polymorphisms that are associated with clinical disease or treatment success, has obvious benefits. ..
- Anger Control Training for Youth with Tourette SyndromeLarry Scahill; Fiscal Year: 2005..This design will permit demonstration of a clinically relevant effect size for anger control training in adolescents with TS. ..
- Clinical and Neuropsychological Investigations in Batten DiseaseJonathan W Mink; Fiscal Year: 2010..Although JNCL is a rare disease, our research has implications that can be generalized to the study of other degenerative neurologic disorders in children and for preparing translational clinical trials in these diseases. ..
- Novel Pharmacological Strategies in AutismChristopher McDougle; Fiscal Year: 2009..Phase II (following 6 months of aripiprazole monotherapy). ..
- Study of risk factors of tick-borne encephalitis in PolandPawel Stefanoff; Fiscal Year: 2009....
- MOLECULAR GENETICS OF OBSESSIVE COMPULSIVE DISORDERGREGORY HANNA; Fiscal Year: 2001..Parametric and nonparametric linkage analyses will be performed. Once evidence for linkage between early-onset OCD and a genetic marker is found, more precise gene localization will be pursued. ..
- RUPP-PIChristopher McDougle; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] ..
- LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDERMarco Grados; Fiscal Year: 2006..Based on results from initial analyses and developing collaborations with other research groups future research projects, such as a genome-wide screen of OCD, are considered. ..
- PATHOPHYSIOLOGY OF CHOREAJonathan Mink; Fiscal Year: 2002..abstract_text> ..
- TREATMENT OF EARLY ONSET SCHIZOPHRENIA SPECTRUM (TEOSS)Robert Findling; Fiscal Year: 2005..This study will provide information about the comparative effectiveness of the most commonly used and representative antipsychotic drugs in youth with schizophrenia spectrum disorders. ..
- D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive DisorderEric Storch; Fiscal Year: 2007..Such agents may have utility in improving outcome, reducing premature therapy termination, and targeting patients who have been treatment refractory. [unreadable] [unreadable] [unreadable]..
- BEHAVIOR THERAPY FOR CHILDHOOD OCDJohn Piacentini; Fiscal Year: 2002..The impact of baseline functioning, including family context, and initial change over time on treatment outcome will also be systematically evaluated. ..
- Child/Adolescent Anxiety Multimodal Treatment StudyJohn Piacentini; Fiscal Year: 2007..unreadable] [unreadable]..
- Behavior Therapy for Children with Chronic Tic DisordersJohn Piacentini; Fiscal Year: 2007Chronic tic disorders (CTD), including Tourette Syndrome (TS), are neurobehavioral disorders characterized by a persistent pattern of motor and vocal tics...
- UTAH AUTISM PROGRAMWilliam McMahon; Fiscal Year: 2006..Finally, he proposes to perform microarray analyses on RNA isolated from peripheral blood mononucler cells of autistic children versus control subjects. ..
- NEUROIMMUNOLOGY OF CHILDHOOD PSYCHIATRIC DISORDERSTanya Murphy; Fiscal Year: 2005..test the following hypotheses: 1) Is there, evidence of immune dysfunction in children with OCD and/or chronic tic disorders (CTD)?;and 2) Is immune dysfunction more evident during symptom exacerbations? Exploring the role of immune ..
- BIOSOCIAL ACTIVATION OF SEX-LINKED COGNITIVE BEHAVIORGERIANNE ALEXANDER; Fiscal Year: 2005..This information will therefore increase understanding of the relations among typical or atypical reproductive events (e.g., puberty, hormone deficiency, pregnancy) and cognition. ..
- Dopaminergic Effects on Cortical Function in Tourette'sKevin J Black; Fiscal Year: 2010Chronic tic disorders including Tourette syndrome (TS) affect at least 2% of all school children and often persist into adulthood...
- A Simple Measure for Studying Sensory Gating DeficitsNeal Swerdlow; Fiscal Year: 2007..abstract_text> ..
- NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIESNeal Swerdlow; Fiscal Year: 2006....
- NEUROIMAGING OF INHIBITION & STIMULANT RESPONSE IN ADHDSteven Pliszka; Fiscal Year: 2004..5) We will control for effects of gender and age, in particular girls with ADHD may not show the same neurobiological mechanisms as boys. ..
- Family Based Treatment of Early Childhood OCDHenrietta Leonard; Fiscal Year: 2004..At the end of the study, a final revised, comprehensive, manualized treatment protocol would be completed which could be tested in large efficacy and effectiveness studies. ..
- Testing Dopaminergic Function Using Pharmacologic FMRIKevin Black; Fiscal Year: 2003..abstract_text> ..
- Prospective Study of 'PANDAS'Tanya Murphy; Fiscal Year: 2006..The results will help determine if antimicrobial interventions are warranted in certain subtypes of pediatric OCD or TS. ..
- Neuroscience at the Boundaries of Neurology and PsychiatryNeal Swerdlow; Fiscal Year: 2006..unreadable] [unreadable]..
- OCD Collaborative Genetics Association StudyGerald Nestadt; Fiscal Year: 2010..The results of these analyses will guide future molecular strategies to identify genes involved in the pathogenesis of OCD. The clinical and genotype data from the sample will be publicly available for OCD genetics research. ..
- Depression in Temporal Lobe EpilepsyJana Jones; Fiscal Year: 2005....
- Neural basis of heritable DA-mediated gating deficitsNeal R Swerdlow; Fiscal Year: 2010....
- Patterns of Service Use and Costs Associated with AutismDouglas Leslie; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Brain Abnormalities in Adolescent Bipolar DisorderMelissa Delbello; Fiscal Year: 2006..The research conducted will advance our understanding of the neurophysiology of BPD. ..
- IMPACT OF SERVICES ON PROBLEM DRINKING TRAJECTORIESKevin Delucchi; Fiscal Year: 2009....
- EPIDEMIOLOGY OF PERSONALITY DISORDERSGerald Nestadt; Fiscal Year: 2008..Building on our previous contributions, this proposal applies innovative constructs of disordered personality and rigorous analytic strategies. ..
- CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATINGNeal R Swerdlow; Fiscal Year: 2010..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
- Awareness Enhancement and Monitoring Device for Treatment of TrichotillomaniaJoseph Himle; Fiscal Year: 2007..Available psychological treatments are only partially helpful and this device when integrated with current treatments could substantially improve the lives of sufferers and their families. [unreadable] [unreadable] [unreadable]..
- Collaborative OCD Genetics StudyGerald Nestadt; Fiscal Year: 2005..abstract_text> ..
- Dopaminergic Modulation of Working Memory in PDTamara Hershey; Fiscal Year: 2005..Modulation of the lateral prefrontal cortex is predicted during levodopa infusion. The degree of modulation is predicted to depend on baseline dopaminergic status (PD vs control) and the degree of memory load (low vs high). ..
- Topiramate for Co-occurring Cannabis Use and Bipolar Disorders in AdolescentsMelissa Delbello; Fiscal Year: 2008..The preliminary data from this projectwill inform and guide the design of future larger, more definitive, controlled studies of topiramate as a treatment for adolescent substance use disorders. ..