asperger syndrome

Summary

Summary: A childhood disorder predominately affecting boys and similar to autism (AUTISTIC DISORDER). It is characterized by severe, sustained, clinically significant impairment of social interaction, and restricted repetitive and stereotyped patterns of behavior. In contrast to autism, there are no clinically significant delays in language or cognitive development. (From DSM-IV)

Top Publications

  1. ncbi Verbal bias in recognition of facial emotions in children with Asperger syndrome
    J B Grossman
    Department of Psychology, Yale University, New Haven, Connecticut 06520 8205, USA
    J Child Psychol Psychiatry 41:369-79. 2000
  2. ncbi The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians
    S Baron-Cohen
    Departments of Experimental Psychology and Psychiatry, University of Cambridge, Downing Street, Cambridge, CB2 3EB, United Kingdom
    J Autism Dev Disord 31:5-17. 2001
  3. ncbi The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism
    S Baron-Cohen
    Department of Experimental Psychology, University of Cambridge, UK
    J Child Psychol Psychiatry 42:241-51. 2001
  4. ncbi Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome
    R T Schultz
    Child Study Center, Yale University, New Haven, Conn 06520 7900, USA
    Arch Gen Psychiatry 57:331-40. 2000
  5. ncbi The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences
    Simon Baron-Cohen
    Autism Research Centre, Department of Experimental Psychology, University of Cambridge, Douglas House, 18b Trumpington Rd, CB2 2AH United Kingdom
    J Autism Dev Disord 34:163-75. 2004
  6. ncbi Enhanced perceptual functioning in autism: an update, and eight principles of autistic perception
    Laurent Mottron
    Pervasive Developmental Disorders Specialized Clinic, Riviere des Prairies Hospital, and Fernand Seguin Research Center, University of Montreal, Canada
    J Autism Dev Disord 36:27-43. 2006
  7. ncbi Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes
    Fulvia Castelli
    Institute of Cognitive Neuroscience, University College London, UK
    Brain 125:1839-49. 2002
  8. ncbi Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the Multifaceted Empathy Test (MET)
    Isabel Dziobek
    Neurocognition of Decision Making, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
    J Autism Dev Disord 38:464-73. 2008
  9. pmc Can Asperger syndrome be distinguished from autism? An anatomic likelihood meta-analysis of MRI studies
    Kevin K Yu
    Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong
    J Psychiatry Neurosci 36:412-21. 2011
  10. ncbi Differential activation of the amygdala and the 'social brain' during fearful face-processing in Asperger Syndrome
    Chris Ashwin
    Autism Research Centre, University of Cambridge, Department of Psychiatry, Douglas House, 18b Trumpington Rd, Cambridge CB2 2AH, UK
    Neuropsychologia 45:2-14. 2007

Detail Information

Publications277 found, 100 shown here

  1. ncbi Verbal bias in recognition of facial emotions in children with Asperger syndrome
    J B Grossman
    Department of Psychology, Yale University, New Haven, Connecticut 06520 8205, USA
    J Child Psychol Psychiatry 41:369-79. 2000
    Thirteen children and adolescents with diagnoses of Asperger syndrome (AS) were matched with 13 nonautistic control children on chronological age and verbal IQ...
  2. ncbi The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians
    S Baron-Cohen
    Departments of Experimental Psychology and Psychiatry, University of Cambridge, Downing Street, Cambridge, CB2 3EB, United Kingdom
    J Autism Dev Disord 31:5-17. 2001
    ..Individuals score in the range 0-50. Four groups of subjects were assessed: Group 1: 58 adults with Asperger syndrome (AS) or high-functioning autism (HFA); Group 2: 174 randomly selected controls...
  3. ncbi The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism
    S Baron-Cohen
    Department of Experimental Psychology, University of Cambridge, UK
    J Child Psychol Psychiatry 42:241-51. 2001
    ..Whilst that test succeeded in discriminating a group of adults with Asperger syndrome (AS) or high-functioning autism (HFA) from controls, it suffered from several psychometric problems...
  4. ncbi Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome
    R T Schultz
    Child Study Center, Yale University, New Haven, Conn 06520 7900, USA
    Arch Gen Psychiatry 57:331-40. 2000
    ..Therefore, it is of considerable interest that individuals with autism and related conditions have selective deficits in face recognition (sparing nonface object recognition)...
  5. ncbi The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences
    Simon Baron-Cohen
    Autism Research Centre, Department of Experimental Psychology, University of Cambridge, Douglas House, 18b Trumpington Rd, CB2 2AH United Kingdom
    J Autism Dev Disord 34:163-75. 2004
    ..In Study 1 we employed the EQ with n = 90 adults (65 males, 25 females) with Asperger Syndrome (AS) or high-functioning autism (HFA), who are reported clinically to have difficulties in empathy...
  6. ncbi Enhanced perceptual functioning in autism: an update, and eight principles of autistic perception
    Laurent Mottron
    Pervasive Developmental Disorders Specialized Clinic, Riviere des Prairies Hospital, and Fernand Seguin Research Center, University of Montreal, Canada
    J Autism Dev Disord 36:27-43. 2006
    ..and in the variability of apparent presentations within PDD (autism with and without typical speech, Asperger syndrome) in non-savant autistics...
  7. ncbi Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes
    Fulvia Castelli
    Institute of Cognitive Neuroscience, University College London, UK
    Brain 125:1839-49. 2002
    Ten able adults with autism or Asperger syndrome and 10 normal volunteers were PET scanned while watching animated sequences...
  8. ncbi Dissociation of cognitive and emotional empathy in adults with Asperger syndrome using the Multifaceted Empathy Test (MET)
    Isabel Dziobek
    Neurocognition of Decision Making, Max Planck Institute for Human Development, Lentzeallee 94, 14195 Berlin, Germany
    J Autism Dev Disord 38:464-73. 2008
    ..the Multifaceted Empathy Test (MET), to assess empathy multidimensionally in a group of 17 individuals with Asperger syndrome (AS) and 18 well-matched controls...
  9. pmc Can Asperger syndrome be distinguished from autism? An anatomic likelihood meta-analysis of MRI studies
    Kevin K Yu
    Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong
    J Psychiatry Neurosci 36:412-21. 2011
    The question of whether Asperger syndrome can be distinguished from autism has attracted much debate and may even incur delay in diagnosis and intervention...
  10. ncbi Differential activation of the amygdala and the 'social brain' during fearful face-processing in Asperger Syndrome
    Chris Ashwin
    Autism Research Centre, University of Cambridge, Department of Psychiatry, Douglas House, 18b Trumpington Rd, Cambridge CB2 2AH, UK
    Neuropsychologia 45:2-14. 2007
    ..Thirteen adults with high-functioning autism or Asperger Syndrome (HFA/AS) and 13 matched controls...
  11. ncbi Association of DISC1 with autism and Asperger syndrome
    H Kilpinen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
    Mol Psychiatry 13:187-96. 2008
    ..clustered in 1q42, in Finnish families ascertained for infantile autism (97 families, n(affected)=138) and Asperger syndrome (29 families, n(affected)=143)...
  12. doi Mindblind eyes: an absence of spontaneous theory of mind in Asperger syndrome
    Atsushi Senju
    Centre for Brain and Cognitive Development, Birkbeck, University of London, London, UK
    Science 325:883-5. 2009
    Adults with Asperger syndrome can understand mental states such as desires and beliefs (mentalizing) when explicitly prompted to do so, despite having impairments in social communication...
  13. ncbi Brief report: postural reactivity to fast visual motion differentiates autistic from children with Asperger syndrome
    Bruno Gepner
    Centre de Psychiatrie de l Enfant, Montperrin Hospital, Aix en Provence, France
    J Autism Dev Disord 32:231-8. 2002
    ..1995), we sought to determine whether children with Asperger syndrome (AS) would share the same postural hyporeactivity to visual motion...
  14. ncbi Finding a face in the crowd: testing the anger superiority effect in Asperger Syndrome
    Chris Ashwin
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK
    Brain Cogn 61:78-95. 2006
    ..Autism and Asperger Syndrome (AS) are neurodevelopmental conditions characterised by social deficits, abnormal face processing, and ..
  15. doi Psychiatric comorbidity in young adults with a clinical diagnosis of Asperger syndrome
    Tove Lugnegård
    Department of Adult Habilitation, Central Hospital, Karlstad, Sweden
    Res Dev Disabil 32:1910-7. 2011
    ..The aim of the present study was to investigate psychiatric comorbidity in young adults with Asperger syndrome. Participants were 26 men and 28 women (mean age 27 years) with a clinical diagnosis of Asperger syndrome...
  16. ncbi Who cares? Revisiting empathy in Asperger syndrome
    Kimberley Rogers
    Millhauser Laboratories, Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    J Autism Dev Disord 37:709-15. 2007
    A deficit in empathy has consistently been cited as a central characteristic of Asperger syndrome (AS), but previous research on adults has predominantly focused on cognitive empathy, effectively ignoring the role of affective empathy...
  17. doi Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome
    B Chakrabarti
    Autism Research Centre, Department of Psychiatry, Cambridge University, UK
    Autism Res 2:157-77. 2009
    ..Here we report a study of common genetic variation in candidate genes associated with autistic traits and Asperger syndrome (AS)...
  18. doi Absence of embodied empathy during pain observation in Asperger syndrome
    Ilaria Minio-Paluello
    Dipartimento di Psicologia, Sapienza, Universita di Roma, Rome, Italy
    Biol Psychiatry 65:55-62. 2009
    b>Asperger syndrome (AS) is a neurodevelopmental condition within the autism spectrum conditions (ASC) characterized by specific difficulties in communication, social interaction, and empathy that is essential for sharing and understanding ..
  19. ncbi Systemizing empathy: teaching adults with Asperger syndrome or high-functioning autism to recognize complex emotions using interactive multimedia
    Ofer Golan
    Autism Research Centre, University of Cambridge, Department of Psychiatry, Cambridge, UK
    Dev Psychopathol 18:591-617. 2006
    ..Mind Reading, an interactive systematic guide to emotions, for its effectiveness in teaching adults with Asperger syndrome (AS) and high-functioning autism (HFA) to recognize complex emotions in faces and voices...
  20. pmc The systemizing quotient: an investigation of adults with Asperger syndrome or high-functioning autism, and normal sex differences
    Simon Baron-Cohen
    Autism Research Centre, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Philos Trans R Soc Lond B Biol Sci 358:361-74. 2003
    ..In Study 2 we employed the SQ and the EQ with n = 47 adults (33 males, 14 females) with Asperger syndrome (AS) or high-functioning autism (HFA), who are predicted to be either normal or superior at systemizing, but ..
  21. ncbi Social skills training for adolescents with Asperger syndrome and high-functioning autism
    Jeanie Tse
    Division of Child and Adolescent Psychiatry, McGill University Health Center, Montreal, QC, Canada
    J Autism Dev Disord 37:1960-8. 2007
    The effectiveness of a social skills training group for adolescents with Asperger syndrome and high-functioning autism (AS/HFA) was evaluated. Parents of six groups of adolescents (n = 46, 61% male, mean age 14...
  22. ncbi Brief report: social and communication abilities and disabilities in higher functioning individuals with autism and Asperger syndrome
    Celine A Saulnier
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    J Autism Dev Disord 37:788-93. 2007
    ..It focuses on the nature of ability and disability in HFA and Asperger syndrome (AS) in relation to age and IQ. Participants included 32 individuals with autism and 35 with AS...
  23. doi 1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders
    Lidia Gabis
    Weinberg Child Development Center, Safra Children s Hospital, Tel Hashomer, Israel
    J Child Neurol 23:766-74. 2008
    ..Magnetic resonance spectroscopy can provide important information regarding abnormal brain metabolism and clinical classification in autism spectrum disorders...
  24. ncbi Social and language skills in adolescent boys with Asperger syndrome
    C Koning
    Glenrose Rehabilitation Hospital, Canada
    Autism 5:23-36. 2001
    Twenty-one adolescent boys with Asperger syndrome and 21 boys matched on age and an estimate of IQ were assessed using standardized measures of social perception (Child and Adolescent Social Perception Measure, CASP), social skills (..
  25. pmc Change in autism symptoms and maladaptive behaviors in adolescents and adults with an autism spectrum disorder
    Paul T Shattuck
    University of Wisconsin, 533 Waisman Ctr, 1500 Highland Ave, Madison, WI 53705, USA
    J Autism Dev Disord 37:1735-47. 2007
    ..Compared to adolescents, older sample members (31 and older) had fewer maladaptive behaviors and experienced more improvement in these behaviors over time...
  26. ncbi Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages
    Francesca Happe
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Brain Cogn 61:25-39. 2006
    ..Within the present groups, the overall findings suggested less severe and persistent EF deficits in ASD (including Asperger Syndrome) than in ADHD.
  27. ncbi Annotation: The similarities and differences between autistic disorder and Asperger's disorder: a review of the empirical evidence
    Kathleen E Macintosh
    School of Psychological Science, La Trobe University, Victoria, Australia
    J Child Psychol Psychiatry 45:421-34. 2004
    ..This paper provides a critical evaluation of current published research evidence...
  28. ncbi Inhibitory control in children with autism spectrum disorder
    Shawn E Christ
    Department of Psychology, Washington University, St Louis, MO, USA
    J Autism Dev Disord 37:1155-65. 2007
    ..More generally, the findings underscore the importance of using multiple measures to assess a putative single cognitive ability...
  29. ncbi Empathising and systemising in adults with and without Asperger Syndrome
    John Lawson
    Autism Research Centre, Department of Experimental Psychology, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 2AH, UK
    J Autism Dev Disord 34:301-10. 2004
    ..Three groups of participants took part in the study: males with Asperger Syndrome (AS) (n = 18), males without AS, (n = 44) and females from the general population (n = 45)...
  30. ncbi fMRI of parents of children with Asperger Syndrome: a pilot study
    Simon Baron-Cohen
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK
    Brain Cogn 61:122-30. 2006
    People with autism or Asperger Syndrome (AS) show altered patterns of brain activity during visual search and emotion recognition tasks. Autism and AS are genetic conditions and parents may show the 'broader autism phenotype.'
  31. doi The anatomy of extended limbic pathways in Asperger syndrome: a preliminary diffusion tensor imaging tractography study
    Luca Pugliese
    Section of Brain Maturation, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Neuroimage 47:427-34. 2009
    ..microstructural integrity and age-related differences in the extended limbic pathways between subjects with Asperger syndrome and healthy controls...
  32. ncbi Outcome in high-functioning adults with autism with and without early language delays: implications for the differentiation between autism and Asperger syndrome
    Patricia Howlin
    Department of Psychology, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, UK
    J Autism Dev Disord 33:3-13. 2003
    The question of whether Asperger syndrome and high-functioning autism should be considered as the same or different conditions has been a source of debate and controversy over recent years...
  33. ncbi Superior fluid intelligence in children with Asperger's disorder
    Mika Hayashi
    Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Brain Cogn 66:306-10. 2008
    ..We suggest that individuals with Asperger's disorder have higher fluid reasoning ability than normal individuals, highlighting superior fluid intelligence...
  34. ncbi Asperger syndrome: a proton magnetic resonance spectroscopy study of brain
    Declan G M Murphy
    Department of Psychological Medicine, St George s Hospital Medical School, London, England
    Arch Gen Psychiatry 59:885-91. 2002
    b>Asperger syndrome (AS; an autistic disorder) is associated with impaired social skills and obsessional/repetitive behavior. Patients with autism have significant abnormalities in the frontal lobe and frontoparietal connectivity...
  35. ncbi The hyper-systemizing, assortative mating theory of autism
    Simon Baron-Cohen
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 2AH, UK
    Prog Neuropsychopharmacol Biol Psychiatry 30:865-72. 2006
    ..They appear 'change-resistant'. This proposal extends the extreme male brain theory of autism. Finally, evidence is reviewed for autism being the genetic result of assortative mating of two high systemizers...
  36. ncbi Asperger syndrome and autism: a comparative longitudinal follow-up study more than 5 years after original diagnosis
    Mats Cederlund
    Department of Child and Adolescent Psychiatry, Institute of Neuroscience and Physiology, Goteborg University, Goteborg, Kungsgatan 12, 411 19, and Queen Silviás and Adolescent Hospital, Sweden
    J Autism Dev Disord 38:72-85. 2008
    Prospective follow-up study of 70 males with Asperger syndrome (AS), and 70 males with autism more than 5 years after original diagnosis...
  37. ncbi Functional anatomy of impaired selective attention and compensatory processing in autism
    Matthew K Belmonte
    Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA 02478 1048, USA
    Brain Res Cogn Brain Res 17:651-64. 2003
    ..These low-level attentional traits may be the developmental basis for higher-order cognitive styles such as weak central coherence...
  38. pmc Abnormal functional specialization within medial prefrontal cortex in high-functioning autism: a multi-voxel similarity analysis
    Sam J Gilbert
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, London, UK
    Brain 132:869-78. 2009
    ..This pattern was disrupted in the ASD group, indicating abnormal functional specialization within mrPFC, and demonstrating the applicability of multi-voxel pattern analysis to investigations of atypical populations...
  39. ncbi Avoidance of emotionally arousing stimuli predicts social-perceptual impairment in Asperger's syndrome
    Ben Corden
    Behavioural and Brain Sciences Unit, Institute of Child Health, University College London WC1N 1EH, UK
    Neuropsychologia 46:137-47. 2008
    ..Furthermore, our findings are consistent with theories implicating amygdala-mediated over-arousal and anxiety in the development of these social-perceptual deficits...
  40. ncbi Reading the mind in the voice: a study with normal adults and adults with Asperger syndrome and high functioning autism
    M D Rutherford
    Department of Experimental Psychology, Autism Research Centre, University of Cambridge, UK
    J Autism Dev Disord 32:189-94. 2002
    People with high functioning autism (HFA) and Asperger syndrome (AS) have deficits in theory of mind (ToM). Traditional ToM tasks are not sensitive enough to measure ToM deficits in adults, so more subtle ToM tests are needed...
  41. pmc Proton MR spectroscopy: higher right anterior cingulate N-acetylaspartate/choline ratio in Asperger syndrome compared with healthy controls
    O Oner
    Child Psychiatry Department, SB Ankara Diskapi Children s Hospital, Ankara, Turkey
    AJNR Am J Neuroradiol 28:1494-8. 2007
    One former study reported higher prefrontal N-acetylaspartate (NAA) levels in patients with Asperger syndrome (AS)...
  42. ncbi A randomised controlled trial of a CBT intervention for anxiety in children with Asperger syndrome
    Kate Sofronoff
    School of Psychology, University of Queensland, Australia kate psy uq edu au
    J Child Psychol Psychiatry 46:1152-60. 2005
    ..study was to evaluate the effectiveness of a brief CBT intervention for anxiety with children diagnosed with Asperger syndrome (AS)...
  43. pmc The level and nature of autistic intelligence II: what about Asperger syndrome?
    Isabelle Soulieres
    Centre d Excellence en Troubles Envahissants du Développement de l Université de Montréal, Montreal, Quebec, Canada
    PLoS ONE 6:e25372. 2011
    ..We investigated whether these findings extend to Asperger syndrome, an autistic spectrum subgroup characterized by verbal peaks of ability, and whether the cognitive ..
  44. ncbi Iron deficiency in autism and Asperger syndrome
    A Latif
    Children Centre, Royal Glamorgan Hospital, Mid Glamorgan, UK
    Autism 6:103-14. 2002
    This research considers the prevalence of iron deficiency in children with autism and Asperger syndrome and examines whether this will influence guidelines and treatment...
  45. ncbi Pervasive developmental disorders in preschool children: confirmation of high prevalence
    Suniti Chakrabarti
    Child Development Centre, Central Clinic, Stafford, UK
    Am J Psychiatry 162:1133-41. 2005
    ..6 per 10,000 in a previous study of preschoolers in Stafford, U.K. They conducted another survey in 2002 to estimate the prevalence in children in a later birth cohort and to compare it to previous findings from the same area...
  46. doi Comorbid psychiatric disorders associated with Asperger syndrome/high-functioning autism: a community- and clinic-based study
    Marja Leena Mattila
    Clinic of Child Psychiatry, University Hospital of Oulu, University of Oulu, Oulu, Finland
    J Autism Dev Disord 40:1080-93. 2010
    The present study identifies the prevalence and types of comorbid psychiatric disorders associated with Asperger syndrome (AS)/high-functioning autism (HFA) in a combined community- and clinic-based sample of fifty 9- to 16-year-old ..
  47. doi Brief report: biochemical correlates of clinical impairment in high functioning autism and Asperger's disorder
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA
    J Autism Dev Disord 39:1079-86. 2009
    ..This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD...
  48. doi Multi-informant reports of psychiatric symptoms among high-functioning adolescents with Asperger syndrome or autism
    Tuula Hurtig
    Institute of Clinical Medicine, Department of Child Psychiatry, University of Oulu, OYS, Finland
    Autism 13:583-98. 2009
    ..Forty-three 11- to 17-year-old adolescents with Asperger syndrome (AS) or high-functioning autism (HFA) and 217 typically developed adolescents completed the Youth Self-..
  49. ncbi Increased presynaptic dopamine function in Asperger syndrome
    Taina S Nieminen-von Wendt
    Department of Child Neurology, Hospital for Children and Adolescents, Helsinki University Central Hospital, PL 280, FIN 00029 HYKS, Helsinki, Finland
    Neuroreport 15:757-60. 2004
    The etiology of Asperger syndrome is essentially unknown, but abnormality of the dopamine system has been shown in clinically overlapping disorders...
  50. ncbi Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in vivo SPECT study
    Declan G M Murphy
    Institute of Psychiatry, Department of Psychological Medicine, London, UK
    Am J Psychiatry 163:934-6. 2006
    ..e., autism and Asperger's syndrome) is unknown. The serotonergic (5-HT) system may be especially implicated. However, cortical 5-HT2A receptor density in adults with the disorder has not been examined, to the authors' knowledge...
  51. ncbi A new 'advanced' test of theory of mind: evidence from children and adolescents with Asperger syndrome
    Nils Kaland
    Lillehammer College, Norway
    J Child Psychol Psychiatry 43:517-28. 2002
    The aim of the present study was to assess the ability of children and adolescents with Asperger syndrome (AS) (N = 21) to infer physical versus mental states on a new 'advanced' test of theory-of-mind - Stories from Everyday Life...
  52. doi Enhanced pure-tone pitch discrimination among persons with autism but not Asperger syndrome
    Anna Bonnel
    McGill University, Department of Educational and Counseling Psychology, Canada
    Neuropsychologia 48:2465-75. 2010
    ..The participants were adolescents and young adults with autism, Asperger syndrome, and typical developmental histories, all with IQs in the normal range...
  53. doi Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging
    Finian M O'Brien
    Department of Psychological Medicine, Kings College London, UK
    Psychiatry Res 184:77-85. 2010
    People with autistic spectrum disorders (ASD, including Asperger syndrome) may have developmental abnormalities in the amygdala-hippocampal complex (AHC)...
  54. doi Similar developmental trajectories in autism and Asperger syndrome: from early childhood to adolescence
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Canada
    J Child Psychol Psychiatry 50:1459-67. 2009
    ..high-functioning children with autism spectrum disorders (ASD) from early childhood to adolescence using the presence and absence of structural language impairment (StrLI) as a way of differentiating autism from Asperger syndrome (AS).
  55. doi Impaired recognition of facial emotions from low-spatial frequencies in Asperger syndrome
    Jari Kätsyri
    Laboratory of Computational Engineering, Helsinki University of Technology, P O Box 9203, FI 02015 TKK, Finland
    Neuropsychologia 46:1888-97. 2008
    ..A group of 20 participants with Asperger syndrome (AS) was compared to a group of non-autistic age- and sex-matched controls...
  56. ncbi Executive processes in Asperger syndrome: patterns of performance in a multiple case series
    Elisabeth L Hill
    Department of Psychology, Goldsmiths College, University of London, New Cross, London SE14 6NW, United Kingdom
    Neuropsychologia 44:2822-35. 2006
    ..A comprehensive battery of 'executive' tests was administered to 22 individuals with Asperger syndrome and 22 well-matched controls...
  57. pmc Conversational behaviors in youth with high-functioning ASD and Asperger syndrome
    Rhea Paul
    Southern Connecticut State University, New Haven, USA
    J Autism Dev Disord 39:115-25. 2009
    ..The implications of these findings for understanding and treating conversational deficits in ASD are discussed...
  58. doi Social anxiety in high-functioning children and adolescents with Autism and Asperger syndrome
    Sanna Kuusikko
    Clinic of Child Psychiatric, University and University Hospital of Oulu, Oulu, Finland
    J Autism Dev Disord 38:1697-709. 2008
    ..and the Child Behavior Checklist (CBCL) in a sample of fifty-four high-functioning subjects with autism or Asperger syndrome (HFA/AS) (M = 11.2 +/- 1.7 years) and 305 community subjects (M = 12.2 +/- 2.2 years)...
  59. ncbi Predictors of outcome among high functioning children with autism and Asperger syndrome
    P Szatmari
    McMaster University, Canada
    J Child Psychol Psychiatry 44:520-8. 2003
    The objective of this paper is to assess the extent to which measures of cognitive abilities taken in an inception cohort of young high functioning children with autism and Asperger syndrome predict outcome roughly two and six years later.
  60. pmc Brief report: The use of WAIS-III in adults with HFA and Asperger syndrome
    Antoinette A Spek
    Mental Health Center GGZ Eindhoven, Boschdijk 771, Postvak 1418, Eindhoven, The Netherlands
    J Autism Dev Disord 38:782-7. 2008
    The WAIS III was administered to 16 adults with high functioning autism (HFA) and 27 adults with Asperger syndrome. Differences between Verbal Intelligence (VIQ) and Performance Intelligence (PIQ) were not found...
  61. ncbi Advanced mind-reading in adults with Asperger syndrome
    Koen S Ponnet
    Ghent University, Belgium
    Autism 8:249-66. 2004
    This study investigated the mind-reading abilities of 19 adults with Asperger syndrome and 19 typically developing adults. Two static mind-reading tests and a more naturalistic empathic accuracy task were used...
  62. ncbi Egocentrism, allocentrism, and Asperger syndrome
    Uta Frith
    Institute of Cognitive Neuroscience, University College London, UK
    Conscious Cogn 14:719-38. 2005
    ..We suggest here that people with Asperger syndrome suffer from a disconnection between a strong naïve egocentric stance and a highly abstract allocentric ..
  63. ncbi Three diagnostic approaches to Asperger syndrome: implications for research
    Ami Klin
    Yale Child Study Center, 230 South Frontage Road, New Haven, CT 06520, USA
    J Autism Dev Disord 35:221-34. 2005
    To examine the implications for research of the use of three alternative definitions for Asperger syndrome (AS)...
  64. pmc Social attribution processes and comorbid psychiatric symptoms in children with Asperger syndrome
    Jessica A Meyer
    Developmetal Psychopathology Research Unit, University College London, UK
    Autism 10:383-402. 2006
    The factors that place children with Asperger syndrome at risk for comorbid psychiatric symptoms, such as anxiety and depression, remain poorly understood...
  65. ncbi The CAST (Childhood Asperger Syndrome Test): preliminary development of a UK screen for mainstream primary-school-age children
    Fiona J Scott
    Autism Research Centre, Department of Psychiatry, University of Cambridge, UK
    Autism 6:9-31. 2002
    The article describes a pilot and follow-up study of the preliminary development of a new tool to screen for Asperger syndrome (AS) and related social and communication conditions (the Childhood Asperger Syndrome Test, CAST) in children ..
  66. ncbi The Adult Asperger Assessment (AAA): a diagnostic method
    Simon Baron-Cohen
    Autism Research Centre, Department of Psychiatry, University of Cambridge, UK
    J Autism Dev Disord 35:807-19. 2005
    At the present time there are a large number of adults who have suspected Asperger syndrome (AS). In this paper we describe a new instrument, the Adult Asperger Assessment (AAA), developed in our clinic for adults with AS...
  67. ncbi A scale to assist the diagnosis of autism and Asperger's disorder in adults (RAADS): a pilot study
    Riva Ariella Ritvo
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA
    J Autism Dev Disord 38:213-23. 2008
    ..The RAADS does not distinguish between autism and Asperger's Disorder...
  68. doi White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults
    Oswald J N Bloemen
    Section of Brain Maturation, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Autism Res 3:203-13. 2010
    Autistic Spectrum Disorder (ASD), including Asperger syndrome and autism, is a highly genetic neurodevelopmental disorder...
  69. ncbi Temperament and character in adults with Asperger syndrome
    Henrik Soderstrom
    Department of Forensic Psychiatry, Goteborg University, Sweden
    Autism 6:287-97. 2002
    To study the personality characteristics of adults with Asperger syndrome, and investigate the value of self-rating personality inventories, we administered the Temperament and Character Inventory (TCI) to 31 outpatients with Asperger ..
  70. ncbi Repetitive behavior profiles in Asperger syndrome and high-functioning autism
    Mikle South
    Department of Psychology, University of Utah and Utah Autism Research Project, USA
    J Autism Dev Disord 35:145-58. 2005
    ..had two major aims: (1) to provide a detailed characterization of repetitive behaviors in individuals with Asperger Syndrome (AS), high-functioning autism (HFA), and typically developing controls (TD); and (2) to examine whether ..
  71. ncbi Neurophysiological evidence for cortical discrimination impairment of prosody in Asperger syndrome
    T Kujala
    Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland
    Neurosci Lett 383:260-5. 2005
    b>Asperger syndrome (AS), belonging to the autism spectrum of disorders, is one of the pervasive developmental disorders...
  72. ncbi Voxel-based morphometry elucidates structural neuroanatomy of high-functioning autism and Asperger syndrome
    Hower Kwon
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Dev Med Child Neurol 46:760-4. 2004
    ..images were acquired for nine males with high-functioning autism (HFA; mean age 14y [SD3y 4mo]), 11 with Asperger syndrome (ASP; mean age 13y 6mo [SD2y 5mo]), and 13 comparison (COM) participants (mean age 13y 7mo [SD 3y 1mo])...
  73. ncbi Attributing social meaning to ambiguous visual stimuli in higher-functioning autism and Asperger syndrome: The Social Attribution Task
    A Klin
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Child Psychol Psychiatry 41:831-46. 2000
    More able individuals with autism and Asperger syndrome (AS) have been shown to pass relatively high level theory of mind (ToM) tasks without displaying commensurate levels of social adaptation in naturalistic settings...
  74. ncbi Psychosocial functioning in a group of Swedish adults with Asperger syndrome or high-functioning autism
    I Engstrom
    Psychiatric Research Centre, Orebro, Sweden
    Autism 7:99-110. 2003
    This study reports on psychosocial functioning in Swedish adults with Asperger syndrome (AS) or high-functioning autism (HFA)...
  75. ncbi Speech and prosody characteristics of adolescents and adults with high-functioning autism and Asperger syndrome
    L D Shriberg
    Waisman Center on Mental Retardation and Human Development, University of Wisconsin Madison, 53705, USA
    J Speech Lang Hear Res 44:1097-115. 2001
    ..and prosody-voice profiles for 15 male speakers with High-Functioning Autism (HFA) and 15 male speakers with Asperger syndrome (AS) were compared to one another and to profiles for 53 typically developing male speakers in the same 10- ..
  76. ncbi Auditory perception and attention as reflected by the brain event-related potentials in children with Asperger syndrome
    T Lepistö
    Cognitive Brain Research Unit, Department of Psychology, P O Box 9, FIN 00014 University of Helsinki, Finland
    Clin Neurophysiol 117:2161-71. 2006
    ..development is delayed and deviant in individuals with autism, but proceeds quite normally in those with Asperger syndrome (AS)...
  77. ncbi Neuropsychological functioning in adults with Asperger syndrome
    Fiona Z Ambery
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Autism 10:551-64. 2006
    There is some consensus in the literature regarding the cognitive profile of people with Asperger syndrome (AS)...
  78. ncbi 'All that glitters is not gold': misdiagnosis of psychosis in pervasive developmental disorders--a case series
    David R Dossetor
    Department of Psychological Medicine, Children s Hospital at Westmead, University of Sydney, NSW, Australia
    Clin Child Psychol Psychiatry 12:537-48. 2007
    ..It is evident that more needs to be done to improve diagnostic reliability of psychosis in PDD, by improving clinical awareness and research tools...
  79. ncbi The CAST (Childhood Asperger Syndrome Test): test accuracy
    Jo Williams
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, UK
    Autism 9:45-68. 2005
    The Childhood Asperger Syndrome Test (CAST) is a parental questionnaire to screen for autism spectrum conditions. In this validation study, the CAST was distributed to 1925 children aged 5-11 in mainstream Cambridgeshire schools...
  80. doi Immune allergic response in Asperger syndrome
    Elizabeth S Magalhães
    Laboratory of Neurobiology and Clinical Neurophysiology, Neurology Section, Pediatric Department, Fernandes Figueira Institute, FIOCRUZ, Brazil
    J Neuroimmunol 216:108-12. 2009
    ..These findings suggest that atopy is frequent in this subgroup of autism implying that allergic inflammation might be an important feature in Asperger syndrome.
  81. doi Obsessive-compulsive traits in children and adolescents with Asperger syndrome
    Liliana Ruta
    Division of Child Neurology and Psychiatry, Department of Paediatrics, University of Catania, 95123 Catania, Italy
    Eur Child Adolesc Psychiatry 19:17-24. 2010
    ..occurrence and characteristic features of obsessive-compulsive behaviours in children and adolescents with Asperger syndrome (AS), with respect to a matched obsessive compulsive disorder group (OCD) and a typically developing control ..
  82. ncbi Clinical evidence that Asperger's disorder is a mild form of autism
    Riva Ariella Ritvo
    Yale University School of Medicine, Yale Child Study Center, New Haven, CT 06520, USA
    Compr Psychiatry 49:1-5. 2008
    ..The aim of this study is to obtain clinical evidence to test the hypothesis that Asperger's disorder (AD) is a mild form of autism (AU)...
  83. ncbi The mitochondrial DNA A3243A>G mutation must be an infrequent cause of Asperger syndrome
    Lindsey Kent
    J Pediatr 149:280-1. 2006
  84. ncbi Auditory cortical change detection in adults with Asperger syndrome
    Tuulia Lepistö
    Cognitive Brain Research Unit, Department of Psychology, P O Box 9, University of Helsinki, and Department of Child Neurology, Helsinki University Central Hospital, Finland
    Neurosci Lett 414:136-40. 2007
    The present study investigated whether auditory deficits reported in children with Asperger syndrome (AS) are also present in adulthood...
  85. ncbi Global and configural visual processing in adults with autism and Asperger syndrome
    Cecilie Rondan
    Mediterranean Institute for Cognitive Neurosciences, UMR 6193, CNRS, 31 Chemin Joseph Aiguier, Marseille Cedex, France
    Res Dev Disabil 28:197-206. 2007
    This study was designed to explore how adults with autism and Asperger syndrome (ASD) would visually process compound figures...
  86. ncbi Tactile sensitivity in Asperger syndrome
    Sarah Jayne Blakemore
    Department of Psychology, Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
    Brain Cogn 61:5-13. 2006
    People with autism and Asperger syndrome are anecdotally said to be hypersensitive to touch. In two experiments, we measured tactile thresholds and suprathreshold tactile sensitivity in a group of adults with Asperger syndrome...
  87. ncbi Asperger syndrome: can the disorder be diagnosed in the adult age?
    Anna Sintes
    Psychiatry and Psychology Service CIBERSAM, Hospital Sant Joan de Deu Esplugues de Llobregat, Barcelona
    Actas Esp Psiquiatr 39:196-200. 2011
    b>Asperger Syndrome (AS) is characterized by a qualitative disorder of social interaction, a pattern of restrictive, repetitive and stereotyped behavior, interests and activities, with normal intellectual capacity and normal language ..
  88. ncbi The classification of autism, Asperger's syndrome, and pervasive developmental disorder
    P Szatmari
    Department of Psychiatry and Behavioural Neursosciences, McMaster University, Hamilton, Ontario
    Can J Psychiatry 45:731-8. 2000
    ..I review the historical development of the classification of PDD, summarize recent empirical data on issues of reliability and validity, and suggest a new approach to classification and understanding...
  89. ncbi Quantitative assessment of neuromotor function in adolescents with high functioning autism and Asperger Syndrome
    Christine M Freitag
    Department of Child and Adolescent Psychiatry, Saarland University Hospital, 66421 Homburg Saar, Germany
    J Autism Dev Disord 37:948-59. 2007
    Motor impairment in children with Asperger Syndrome (AS) or High functioning autism (HFA) has been reported previously. This study presents results of a quantitative assessment of neuromotor skills in 14-22 year old HFA/AS.
  90. ncbi Head circumference in autism, Asperger syndrome, and ADHD: a comparative study
    Christopher Gillberg
    Department of Psychiatry, St George s Hospital Medical School, London, UK
    Dev Med Child Neurol 44:296-300. 2002
    ..Fifty consecutive children with Asperger syndrome (45 males, five females; mean age 9 years, range 1 year 6 months to 16 years) without indications of ..
  91. ncbi Defining the intellectual profile of Asperger Syndrome: comparison with high-functioning autism
    Mohammad Ghaziuddin
    Division of Child and Adolesccnt Psychiatry, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0390, USA
    J Autism Dev Disord 34:279-84. 2004
    b>Asperger syndrome (AS) is a disorder of early childhood characterized by autistic social deficits, subtle communication impairment, and excessive isolated interests. There is no history of language delay or of mental retardation...
  92. ncbi Anxiety and social worries in children with Asperger syndrome
    Emily Russell
    School of Psychology, University of Queensland, Brisbane, Queensland, Australia
    Aust N Z J Psychiatry 39:633-8. 2005
    The current study examined anxiety and social worries in a group of children with Asperger syndrome (AS).
  93. ncbi Understanding and negotiating friendships: perspectives from an adolescent with Asperger syndrome
    Brooke Howard
    Boston University, Boston, MA, USA
    Autism 10:619-27. 2006
    This case study explored perceptions of friendship of an adolescent with Asperger syndrome. Data were collected through semi-structured interviews, photographs taken by the adolescent, and quality of life and friendship measures...
  94. ncbi Higher plasma ACTH levels in adults with Asperger syndrome
    Pekka Tani
    Department of Psychiatry, University of Helsinki, Finland
    J Psychosom Res 58:533-6. 2005
    The aim of this preliminary study was to characterize the levels of plasma adrenocorticotropic hormone (ACTH) and cortisol in adult patients with Asperger syndrome (AS).
  95. ncbi Disembedding performance in children and adolescents with Asperger syndrome or high-functioning autism
    Nils Kaland
    Lillehammer University College, Faculty of Social Science, Norway
    Autism 11:81-92. 2007
    ..The participants in the present study were children and adolescents with Asperger syndrome (AS) or high-functioning autism (HFA) (N = 13), and a matched group of typically developing children and ..
  96. doi Neuropsychological mechanisms of Digit Symbol Substitution Test impairment in Asperger Disorder
    Roni Yoran-Hegesh
    Research Unit, Beer Yakov Nes Ziona Mental Health Center, Nes Ziona, Israel
    Psychiatry Res 166:35-45. 2009
    ..Future neuroimaging studies are needed to clarify the neural network involved in the differences in cognitive performance between AD subjects and normal controls...
  97. doi Absence of a normal cortisol awakening response (CAR) in adolescent males with Asperger syndrome (AS)
    Mark Brosnan
    Department of Psychology, University of Bath, Bath BA2 7AY, UK
    Psychoneuroendocrinology 34:1095-100. 2009
    ..This study examined whether the CAR was evident in 20 adolescent males with Asperger Syndrome (AS) and 18 age-matched typically developing (TD) controls (aged 11-16)...
  98. ncbi Reflections on opening Pandora's box
    Lorna Wing
    National Autistic Society Centre for Social and Communication Disorders, Elliot House, 113 Masons Hill, Bromley, Kent, BR2 9HT, UK
    J Autism Dev Disord 35:197-203. 2005
    ..It has highlighted the special contribution people with Asperger syndrome have made to the world. There has been a growth of specialist services but many more are needed...
  99. ncbi Investigation of neuroanatomical differences between autism and Asperger syndrome
    Linda J Lotspeich
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Arch Gen Psychiatry 61:291-8. 2004
    Autism and Asperger syndrome (ASP) are neurobiological conditions with overlapping behavioral symptoms and of unknown etiologies...
  100. ncbi Lessons learnt in conducting a clinical drug trial in children with Asperger Syndrome
    John Mathai
    Child and Adolescent Psychiatrist, Royal Children s Hospital, Mental Health Service, Parkville, Vic, Australia
    Australas Psychiatry 13:173-5. 2005
    To describe the authors' experience of conducting a clinical drug trial in children with Asperger Syndrome, including the pitfalls encountered and lessons learnt.
  101. ncbi A survey of sleep problems in autism, Asperger's disorder and typically developing children
    M A Polimeni
    Psychology and Disability Studies, School of Health Sciences, RMIT University, Bundoora, Australia
    J Intellect Disabil Res 49:260-8. 2005
    ..The aim of this study was to compare sleep patterns of children with autism and AD to a TD group of children...

Research Grants71

  1. Social Skills Intervention for Adolescents with High Functioning Autism/Asperger
    Dorothy Strickland; Fiscal Year: 2007
    ..component, can ameliorate these problematic behaviors in children with high functioning autism and Asperger Syndrome (HFA/AS), disorders often grouped in the autism spectrum...
  2. GENOTYPE AND PHENOTYPE OF BRAINSTEM INJURY IN AUTISM
    Patricia Rodier; Fiscal Year: 2007
    ..deficits, and mutations of early developmental genes in four groups with developmental disabilities (autism, Asperger syndrome, Mbius syndrome, and language disorder) and controls with typical development...
  3. Portable Guidance in Autism Spectrum Disorder
    Gary Mesibov; Fiscal Year: 2005
    ..aim to improve the social and executive functioning of Asperger Syndrome/High Functioning Autistic persons (AS/HFA) through an intervention program that features Portable, ..
  4. CBT/Comorbid Anxiety Disorders/Children/Asperger Syndro*
    Jeffrey Wood; Fiscal Year: 2005
    Anxiety disorders are commonly diagnosed in children with Asperger syndrome (AS) and pervasive developmental disorder not otherwise specified (PDD-NOS)...
  5. Supporting Transition In Vocation and Education (STRIVE)
    Cynthia Baker; Fiscal Year: 2007
    ..support training materials for use in special education or advocacy settings for individuals with Asperger Syndrome and/or High-Functioning Autism (AS/HFA)...
  6. Cognitive Effects of Cerebellar Dysfunction in Autism
    Jeanne Townsend; Fiscal Year: 2007
    ..with autism: 1) to patients with cerebellar damage acquired in early childhood; and 2) to those with Asperger syndrome in which the cerebellum may be less affected...
  7. Autism: Social And Communication Predictors in Siblings
    Rebecca Landa; Fiscal Year: 2005
    Autism spectrum disorders (ASD, including Autism, Pervasive Developmental Disorder-Not Otherwise Specified, Asperger syndrome) are characterized by significant impairment in communication and emotional understanding and expression, as ..
  8. The fusiform and amygalda in the pathobiology of autism
    Robert Schultz; Fiscal Year: 2009
    ..Persons with an autism spectrum disorder (ASD: autism, asperger syndrome and pervasive developmental disorder not otherwise specified) have a variety of deficits in the manner in ..
  9. The Epidemiology of Autism in a Low Birthweight Cohort
    Jennifer Pinto Martin; Fiscal Year: 2007
    ..re-assessed at age 15-16 and parent report on screens for ASD (Social Communication Questionnaire and the Asperger Syndrome Screening Questionnaire) was obtained...
  10. GOAL DIRECTED MAGNETIC RESONANCE BRAIN MICRO IMAGING
    Russell Jacobs; Fiscal Year: 2002
    ..reciprocal social interaction and repetitive, odd behaviors. Asperger syndrome (AS) shares many features with autism, and may therefore have a largely overlapping, but nevertheless ..
  11. Divergence and Variability of Language Maps in Autism
    RALPH AXEL MUELLER; Fiscal Year: 2006
    ..Thirty verbal individuals with autism, 24 subjects with Asperger syndrome (AS), and age, gender, and handedness-matched controls will be studied...