cognition disorders


Summary: Disturbances in the mental process related to thinking, reasoning, and judgment.

Top Publications

  1. pmc When does age-related cognitive decline begin?
    Timothy A Salthouse
    Department of Psychology, University of Virginia, Charlottesville, VA 22904 4400, USA
    Neurobiol Aging 30:507-14. 2009
  2. ncbi Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Vic, Australia
    J Affect Disord 113:1-20. 2009
  3. ncbi Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?
    Terry E Goldberg
    Zucker Hillside Hospital, 7559 263rd Street, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 64:1115-22. 2007
  4. ncbi Updated research nosology for HIV-associated neurocognitive disorders
    A Antinori
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Instituto di Ricovero e Cura a Carattere Scientifico IRCCS, Rome, Italy
    Neurology 69:1789-99. 2007
  5. pmc Selective changes of resting-state networks in individuals at risk for Alzheimer's disease
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 104:18760-5. 2007
  6. ncbi The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment
    Ziad S Nasreddine
    Center for Clinical Research, Neurology Service, Hopital Charles LeMoyne, Quebec, Canada
    J Am Geriatr Soc 53:695-9. 2005
  7. ncbi Mild cognitive impairment as a diagnostic entity
    R C Petersen
    Department of Neurology, Alzheimer s Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Intern Med 256:183-94. 2004
  8. pmc HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
    R K Heaton
    University of California, San Diego, USA
    Neurology 75:2087-96. 2010
  9. ncbi Current concepts in mild cognitive impairment
    R C Petersen
    Department of Neurology, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 58:1985-92. 2001
  10. pmc The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis
    Stephanie Debette
    Clinical Neuroscience, St George s University of London, London
    BMJ 341:c3666. 2010

Detail Information

Publications309 found, 100 shown here

  1. pmc When does age-related cognitive decline begin?
    Timothy A Salthouse
    Department of Psychology, University of Virginia, Charlottesville, VA 22904 4400, USA
    Neurobiol Aging 30:507-14. 2009
  2. ncbi Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Vic, Australia
    J Affect Disord 113:1-20. 2009
    ..Our aim was to delineate neuropsychological deficits related to genetic susceptibility, illness process and iatrogenic factors in bipolar disorder (BD)...
  3. ncbi Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?
    Terry E Goldberg
    Zucker Hillside Hospital, 7559 263rd Street, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 64:1115-22. 2007
    ..However, none of these studies included healthy controls undergoing repeated testing to assess the possibility that improvements might reflect simple practice effects...
  4. ncbi Updated research nosology for HIV-associated neurocognitive disorders
    A Antinori
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Instituto di Ricovero e Cura a Carattere Scientifico IRCCS, Rome, Italy
    Neurology 69:1789-99. 2007
    ..An algorithm is proposed to assist in standardized diagnostic classification of HAND...
  5. pmc Selective changes of resting-state networks in individuals at risk for Alzheimer's disease
    Christian Sorg
    Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 104:18760-5. 2007
    ..We interpret our finding as a proof of principle, demonstrating that functional brain disorders can be characterized by functional-disconnectivity profiles of RSNs...
  6. ncbi The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment
    Ziad S Nasreddine
    Center for Clinical Research, Neurology Service, Hopital Charles LeMoyne, Quebec, Canada
    J Am Geriatr Soc 53:695-9. 2005
    ..To develop a 10-minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first-line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia...
  7. ncbi Mild cognitive impairment as a diagnostic entity
    R C Petersen
    Department of Neurology, Alzheimer s Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Intern Med 256:183-94. 2004
    ..By refining the criteria for MCI, clinical trials can be designed with appropriate inclusion and exclusion restrictions to allow for the investigation of therapeutics tailored for specific targets and populations...
  8. pmc HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
    R K Heaton
    University of California, San Diego, USA
    Neurology 75:2087-96. 2010
  9. ncbi Current concepts in mild cognitive impairment
    R C Petersen
    Department of Neurology, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 58:1985-92. 2001
    ..While no treatments are recommended for MCI currently, clinical trials regarding potential therapies are under way. Recommendations concerning ethical issues in the diagnosis and the management of subjects with MCI were made...
  10. pmc The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis
    Stephanie Debette
    Clinical Neuroscience, St George s University of London, London
    BMJ 341:c3666. 2010
    ..To review the evidence for an association of white matter hyperintensities with risk of stroke, cognitive decline, dementia, and death...
  11. ncbi What is cognitive reserve? Theory and research application of the reserve concept
    Yaakov Stern
    G H Sergievsky Center, The Taub Institute, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Int Neuropsychol Soc 8:448-60. 2002
    ..Epidemiologic and imaging data that help to develop and support the concept of reserve are presented...
  12. ncbi Cognitive dysfunction in HIV patients despite long-standing suppression of viremia
    Samanta Simioni
    Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    AIDS 24:1243-50. 2010
    ..To determine the prevalence of cognitive complaints and HIV-associated neurocognitive disorders (HANDs) in a cohort of aviremic HIV-positive patients. To evaluate the relevance of the HIV dementia scale to detect HANDs...
  13. ncbi Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
  14. pmc Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
    Leslie M Shaw
    Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Neurol 65:403-13. 2009
    ..Develop a cerebrospinal fluid biomarker signature for mild Alzheimer's disease (AD) in Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects...
  15. pmc The adaptive brain: aging and neurocognitive scaffolding
    Denise C Park
    The Center for Brain Health, University of Texas at Dallas, Dallas, Texas 75235, USA
    Annu Rev Psychol 60:173-96. 2009
    ..Scaffolding is protective of cognitive function in the aging brain, and available evidence suggests that the ability to use this mechanism is strengthened by cognitive engagement, exercise, and low levels of default network engagement...
  16. ncbi A new rating scale for age-related white matter changes applicable to MRI and CT
    L O Wahlund
    Department of Clinical Neuroscience, Neurotec, Karolinska Institutet at Huddinge University Hospital, Huddinge, Sweden
    Stroke 32:1318-22. 2001
    ..We have developed and evaluated a new scale and studied ARWMC in a large number of patients examined with both MRI and CT...
  17. ncbi Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    Radoslaw Rola
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    Exp Neurol 188:316-30. 2004
    ..These data provide evidence that irradiation of young animals induces a long-term impairment of SGZ neurogenesis that is associated with hippocampal-dependent memory deficits...
  18. ncbi Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
    Kaj Blennow
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, SE 431 80 Molndal, Sweden
    Nat Rev Neurol 6:131-44. 2010
    ..Furthermore, we outline the roles of CSF biomarkers in drug discovery and clinical trials, and provide perspectives on AD biomarker discovery and the validation of such markers for use in the clinic...
  19. ncbi The weak coherence account: detail-focused cognitive style in autism spectrum disorders
    Francesca Happe
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Autism Dev Disord 36:5-25. 2006
    ..Local bias appears not to be a mere side-effect of executive dysfunction, and may be independent of theory of mind deficits. Possible computational and neural models are discussed...
  20. ncbi Neurocognitive deficit in schizophrenia: a quantitative review of the evidence
    R W Heinrichs
    Department of Psychology, York University, Toronto, Ontario, Canada
    Neuropsychology 12:426-45. 1998
    ..The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests...
  21. ncbi CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    JAMA 302:385-93. 2009
  22. ncbi Role of interleukin-1beta in postoperative cognitive dysfunction
    Mario Cibelli
    Department of Anesthetics, Pain Medicine, and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
    Ann Neurol 68:360-8. 2010
    ..We explored whether systemic inflammation, in response to surgical trauma, triggers hippocampal inflammation and subsequent memory impairment, in a mouse model of orthopedic surgery...
  23. ncbi Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, 97239, USA
    Radiat Res 162:39-47. 2004
    ..The significant loss of proliferating SGZ cells and their progeny suggests a contributory role of reduced neurogenesis in the pathogenesis of radiation-induced cognitive impairments...
  24. ncbi Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children
    Cornelieke Sandrine Hanan Aarnoudse-Moens
    Division of Neonatology, Department of Pediatrics, Erasmus University Medical Centre Sophia Children s Hospital, Rotterdam, Netherlands
    Pediatrics 124:717-28. 2009
    ..We conducted a quantitative meta-analysis of studies published between 1998 and 2008 on academic achievement, behavioral functioning, and EF with the aim of providing aggregated measures of effect size for these outcome domains...
  25. ncbi Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review
    Erik G Willcutt
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    Biol Psychiatry 57:1336-46. 2005
    ..Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD...
  26. ncbi Predictors of cognitive dysfunction after major noncardiac surgery
    Terri G Monk
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, 27705, USA
    Anesthesiology 108:18-30. 2008
  27. ncbi Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    Jorge J Palop
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 55:697-711. 2007
    ..Aberrant increases in network excitability and compensatory inhibitory mechanisms in the hippocampus may contribute to Abeta-induced neurological deficits in hAPP mice and, possibly, also in humans with AD...
  28. pmc Neural mechanisms of ageing and cognitive decline
    Nicholas A Bishop
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 464:529-35. 2010
    ..Recent advances in the biology of ageing in model organisms, together with molecular and systems-level studies of the brain, are beginning to shed light on these mechanisms and their potential roles in cognitive decline...
  29. pmc A meta-analysis of cognitive remediation in schizophrenia
    Susan R McGurk
    Dartmouth Psychiatric Research Center, 105 Pleasant Street, Concord, NH 03301, USA
    Am J Psychiatry 164:1791-802. 2007
    ..This study evaluated the effects of cognitive remediation for improving cognitive performance, symptoms, and psychosocial functioning in schizophrenia...
  30. ncbi Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury
    P Grandjean
    Institute of Community Health, Odense University, Denmark
    Neurotoxicol Teratol 19:417-28. 1997
    ..The effects on brain function associated with prenatal methylmercury exposure therefore appear widespread, and early dysfunction is detectable at exposure levels currently considered safe...
  31. ncbi Cognitive deficits in depression: possible implications for functional neuropathology
    M P Austin
    Mood Disorders Unit and Department of Liaison Psychiatry, Prince of Wales Hospital, Sydney, Australia
    Br J Psychiatry 178:200-6. 2001
    ..While depression is known to involve a disturbance of mood, movement and cognition, its associated cognitive deficits are frequently viewed as simple epiphenomena of the disorder...
  32. ncbi The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity
    C Randolph
    Department of Neurology, Loyola University Medical Center, Maywood, IL, USA
    J Clin Exp Neuropsychol 20:310-9. 1998
    ..These data suggest that the RBANS is effective at both detecting and characterizing dementia of different etiologies...
  33. ncbi Long-term consequences of postoperative cognitive dysfunction
    Jacob Steinmetz
    Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Anesthesiology 110:548-55. 2009
    ..Postoperative cognitive dysfunction (POCD) is common in elderly patients after noncardiac surgery, but the consequences are unknown. The authors' aim was to determine the effects of POCD on long-term prognosis...
  34. ncbi Mild cognitive impairment
    Serge Gauthier
    McGill Center for Studies in Aging, Douglas Hospital, Montreal, Quebec, Canada
    Lancet 367:1262-70. 2006
    ..Other definitions and subtypes of mild cognitive impairment need to be studied as potential prodromes of Alzheimer's disease and other types of dementia...
  35. ncbi Altered functional connectivity in early Alzheimer's disease: a resting-state fMRI study
    Kun Wang
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, People s Republic of China
    Hum Brain Mapp 28:967-78. 2007
    ..In addition, the results also suggest that AD may disturb the correlation/anti-correlation effect in the two intrinsically anti-correlated networks...
  36. pmc Long-term effects of cognitive training on everyday functional outcomes in older adults
    Sherry L Willis
    Department of Human Development and Family Studies, Pennsylvania State University, State College, PA 16801
    JAMA 296:2805-14. 2006
    ..Cognitive training has been shown to improve cognitive abilities in older adults but the effects of cognitive training on everyday function have not been demonstrated...
  37. pmc Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline
    Niccolò Terrando
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Proc Natl Acad Sci U S A 107:20518-22. 2010
    ..Taken together, our results suggest a unique therapeutic potential for preemptive treatment with anti-TNF antibody to prevent surgery-induced cognitive decline...
  38. ncbi Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study
    Constantine G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    JAMA 288:1475-83. 2002
    ..Dementia and MCI are associated with neuropsychiatric symptoms in clinical samples. Only 2 population-based studies exist of the prevalence of these symptoms in dementia, and none exist for MCI...
  39. ncbi Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life
    Brenda L Plassman
    Duke University Medical Center, Durham, North Carolina 27701, USA
    Ann Intern Med 153:182-93. 2010
    ..Many biological, behavioral, social, and environmental factors may contribute to the delay or prevention of cognitive decline...
  40. pmc Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study
    Henry W Mahncke
    Posit Science Corporation, 225 Bush Street, San Francisco, CA 94104, USA
    Proc Natl Acad Sci U S A 103:12523-8. 2006
    ..This study demonstrates that intensive, plasticity-engaging training can result in an enhancement of cognitive function in normal mature adults...
  41. ncbi Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies
    Kaarin J Anstey
    Centre for Mental Health Research, School of Psychology, The Australian National University, Canberra, Australia
    Am J Epidemiol 166:367-78. 2007
    ..07, 95% CI: -0.11, -0.03), but the groups were not different regarding risk of vascular dementia or any dementia. The authors concluded that elderly smokers have increased risks of dementia and cognitive decline...
  42. ncbi National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards
    Vladimir Hachinski
    London Health Sciences Centre, University Campus, London, Ontario, Canada
    Stroke 37:2220-41. 2006
  43. ncbi Clock-drawing: is it the ideal cognitive screening test?
    K I Shulman
    Department of Psychiatry, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Ontario, Canada
    Int J Geriatr Psychiatry 15:548-61. 2000
    ..This review aims to synthesize the available evidence and assess the value of this screening test according to well-defined criteria...
  44. ncbi Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
    B C Dickerson
    Department of Neurology, The Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 65:404-11. 2005
    ..To use fMRI to investigate whether hippocampal and entorhinal activation during learning is altered in the earliest phase of mild cognitive impairment (MCI)...
  45. ncbi PET imaging of amyloid deposition in patients with mild cognitive impairment
    Anton Forsberg
    Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
    Neurobiol Aging 29:1456-65. 2008
    ..01). The PIB retention in MCI converters was comparable to AD patients (p>0.01). Correlations were observed in the MCI patients between PIB retention and CSF Abeta(1-42), total Tau and episodic memory, respectively...
  46. ncbi Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes
    Sanne M Manschot
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Diabetes 55:1106-13. 2006
    ..We conclude that cognitive impairments in patients with type 2 diabetes are not only associated with subcortical ischemic changes in the brain, but also with increased brain atrophy...
  47. pmc Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial
    Joseph F Quinn
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    JAMA 304:1903-11. 2010
    ..Epidemiological studies suggest that consumption of DHA is associated with a reduced incidence of Alzheimer disease. Animal studies demonstrate that oral intake of DHA reduces Alzheimer-like brain pathology...
  48. ncbi The prevalence and incidence of neurocognitive impairment in the HAART era
    Kevin R Robertson
    Department of Neurology, UNC, Chapel Hill, North Carolina 27599, USA
    AIDS 21:1915-21. 2007
    ..The effects of HAART on neurological disease are less well understood. The aim of this study was to assess the prevalence and incidence of neurocognitive impairment in individuals who initiated HAART as part of an AIDS clinical trial...
  49. ncbi Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial
    Richard S E Keefe
    Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 64:633-47. 2007
    ..The relative effect of the second-generation (atypical) antipsychotic drugs and older agents on neurocognition has not been comprehensively determined...
  50. ncbi Insights into the ageing mind: a view from cognitive neuroscience
    Trey Hedden
    Stanford University, Psychology Department, 434 Jordan Hall, Building 420, Stanford, California 94305 2130, USA
    Nat Rev Neurosci 5:87-96. 2004
  51. ncbi Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 26:231-9. 2005
    ..These findings suggest that altered activity in the default mode network may act as an early marker for AD pathology...
  52. pmc Mild cognitive impairment: ten years later
    Ronald C Petersen
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Arch Neurol 66:1447-55. 2009
    ..This review summarizes the progress that has been made while also recognizing the challenges that remain...
  53. ncbi Prodromal Alzheimer's disease: successive emergence of the clinical symptoms
    Helene Amieva
    Institut National de la Sante et de la Recherche Medicale, U897, France
    Ann Neurol 64:492-8. 2008
    ..Utilizing the long follow-up of the PAQUID study, we examined the emergence of the first clinical symptoms over a 14-year period of follow-up before the dementia phase of AD...
  54. ncbi Cognitive impairment in multiple sclerosis
    Nancy D Chiaravalloti
    Neuropsychology and Neuroscience Laboratory, Kessler Medical Rehabilitation Research and Education Center, West Orange, NJ 07052, USA
    Lancet Neurol 7:1139-51. 2008
    ..Moreover, examination of efforts to treat the cognitive deficits in MS is still in the early stages...
  55. ncbi Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline
    Karin Yurko-Mauro
    Clinical Research Department, Martek Biosciences Corporation, Columbia, MD, USA
    Alzheimers Dement 6:456-64. 2010
    ..Higher DHA intake is inversely correlated with relative risk of Alzheimer's disease. The potential benefits of DHA supplementation in age-related cognitive decline (ARCD) have not been fully examined...
  56. ncbi The age-dependent relation of blood pressure to cognitive function and dementia
    Chengxuan Qiu
    Aging Research Centre, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institute and Stockholm Gerontology Research Centre, Stockholm, Sweden
    Lancet Neurol 4:487-99. 2005
  57. ncbi Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications
    Carol Gregory
    Fulbourn Hospital, Cambridge, UK
    Brain 125:752-64. 2002
    ..This study supports the hypothesis that patients with fvFTD, but not those with Alzheimer's disease, are impaired on tests of ToM, and may explain some of the abnormalities in interpersonal behaviour that characterize fvFTD...
  58. ncbi Neuropsychiatric and neurodevelopmental outcome of children at age 6 and 7 years who screened positive for language problems at 30 months
    Carmela Miniscalco
    Department of Logopedics and Phoniatrics, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Dev Med Child Neurol 48:361-6. 2006
    ..Remaining language problems at age 6 years strongly predict the presence of neuropsychiatric or neurodevelopmental disorders at age 7 years...
  59. ncbi Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity
    A Giralt
    Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Hum Mol Genet 21:1203-16. 2012
    ..These findings demonstrate an important role for CBP in cognitive dysfunction in HD and suggest the use of histone deacetylase inhibitors as a novel therapeutic strategy for the treatment of memory deficits in this disease...
  60. ncbi Age-associated cognitive decline
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Br Med Bull 92:135-52. 2009
    ..The determinants of the differences in age-related cognitive decline are not fully understood. Progress in the field is taking place across many areas of biomedical and psychosocial sciences...
  61. ncbi The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947
    Ian J Deary
    Department of Psychology, University of Edinburgh, Edinburgh, Scotland
    J Pers Soc Psychol 86:130-47. 2004
  62. ncbi Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials
    Michael Grundman
    Alzheimer s Disease Cooperative Study, Department of Neurosciences, University of California San Diego, 8950 Villa La Jolla Drive, Suite 227, La Jolla, CA 92037, USA
    Arch Neurol 61:59-66. 2004
    ..The Memory Impairment Study (MIS) is a multicenter clinical trial in patients with MCI designed to evaluate whether vitamin E or donepezil is effective at delaying the time to a clinical diagnosis of AD...
  63. pmc Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
    Li Shen
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street R2 E124, Indianapolis, IN 46202, USA
    Neuroimage 53:1051-63. 2010
    ..A genome-wide, whole brain search strategy has the potential to reveal novel candidate genes and loci warranting further investigation and replication...
  64. ncbi Human immunodeficiency virus-associated neurocognitive disorders: Mind the gap
    Justin C McArthur
    NIMH Center for Novel Therapeutics for HIV Associated Cognitive Disorders, Johns Hopkins University, Baltimore, MD, USA
    Ann Neurol 67:699-714. 2010
    ..Novel therapies aimed at persistent central nervous system inflammation will be needed to close this gap...
  65. ncbi Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment
    Nicola Canessa
    Center for Cognitive Neuroscience, Vita Salute San Raffaele University, Milan, Italy
    Am J Respir Crit Care Med 183:1419-26. 2011
    ..Knowledge of the brain structures involved in OSA and the corresponding functional implications could provide clues to the pathogenesis of cognitive impairment and its reversibility in this disorder...
  66. pmc Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis
    David J Hawellek
    Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Proc Natl Acad Sci U S A 108:19066-71. 2011
  67. ncbi A meta-analysis of cognitive deficits in first-episode Major Depressive Disorder
    Rico S C Lee
    Department of Psychology, Macquarie University, NSW, Australia
    J Affect Disord 140:113-24. 2012
    ..The current aim was to systematically evaluate the literature on first-episode MDD to determine whether cognition may be a feasible target for early identification and intervention...
  68. ncbi Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS)
    Ralph H B Benedict
    State University of New York at Buffalo School of Medicine, Department of Neurology, Division of Departmental and Behavioral Neurosciences, Buffalo, New York, USA
    J Int Neuropsychol Soc 12:549-58. 2006
    ..We conclude that the MACFIMS is a valid approach to routine NP assessment of MS patients. Future work is planned to determine its psychometric properties in a longitudinal study...
  69. ncbi Neurocognitive profiles in bipolar I and bipolar II disorder: differences in pattern and magnitude of dysfunction
    Carmen Simonsen
    Department of Psychiatry, Ulleval University Hospital, and Institute of Psychology, University of Oslo, Oslo, Norway
    Bipolar Disord 10:245-55. 2008
    ..The aim of this study was to examine whether patients with bipolar I and bipolar II disorder have different neurocognitive profiles...
  70. ncbi Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis
    R A Dineen
    Department of Academic Radiology, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Brain 132:239-49. 2009
    ..This suggests that TBSS reveals functionally relevant tract injury underlying cognitive dysfunction in patients with multiple sclerosis...
  71. ncbi Elevated body mass index is associated with executive dysfunction in otherwise healthy adults
    John Gunstad
    Department of Psychology, Kent Hall, Kent State University, Kent, OH 44242, USA
    Compr Psychiatry 48:57-61. 2007
    ..Further research is needed to identify the etiology of these deficits and whether they resolve after weight loss...
  72. ncbi Identification of separable cognitive factors in schizophrenia
    Keith H Nuechterlein
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, USA
    Schizophr Res 72:29-39. 2004
    ..These separable cognitive dimensions also have broader relevance to future research aimed at understanding the nature and structure of core cognitive deficits in schizophrenia...
  73. ncbi Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease
    George Bartzokis
    Department of Neurology, UCLA Alzheimer s Disease Center, Los Angeles, CA 90095, USA
    Neurobiol Aging 25:5-18; author reply 49-62. 2004
  74. ncbi White matter damage on diffusion tensor imaging correlates with age-related cognitive decline
    R A Charlton
    Clinical Neuroscience, St George s University of London, UK
    Neurology 66:217-22. 2006
    ..Damage to white matter tracts, resulting in "cerebral disconnection," may underlie age-related cognitive decline...
  75. ncbi Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
    S W Scheff
    Sanders Brown Center on Aging and Alzheimer Disease Research Center, University of Kentucky College of Medicine, Lexington, KY 40536 0230, USA
    Neurology 68:1501-8. 2007
  76. ncbi The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity
    Keith H Nuechterlein
    Department of Psychology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Rm 2251, Los Angeles, CA 90095 6968, USA
    Am J Psychiatry 165:203-13. 2008
  77. ncbi Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease
    Jeremy M Van Raamsdonk
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3 Canada
    J Neurosci 25:4169-80. 2005
  78. ncbi The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3270, Durham, NC 27710, USA
    Schizophr Res 68:283-97. 2004
    ..76) and healthy controls (r=0.90). These psychometric properties make the BACS a promising tool for assessing cognition repeatedly in patients with schizophrenia, especially in clinical trials of cognitive enhancement...
  79. pmc Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease
    Y Zhang
    MR Unit 114M, VA Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurology 68:13-9. 2007
    ..However, it is unclear whether these abnormalities also impact the cingulum fibers, which connect the medial temporal lobe and the posterior cingulate regions...
  80. ncbi The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies
    Inge Klinkenberg
    Faculty of Psychology and Neuroscience, EURON, Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands
    Neurosci Biobehav Rev 34:1307-50. 2010
    ..The use of muscarinic M1 antagonists is suggested as a more selective and effective way of inducing cholinergic-induced cognitive deficits...
  81. pmc Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging, Lexington, KY 40536 0230, USA
    J Neuropathol Exp Neurol 68:1-14. 2009
    ..We argue that existing data strongly support the hypothesis that both amyloid plaques and NFTs contribute to cognitive impairment...
  82. ncbi A prospective study of physical activity and cognitive decline in elderly women: women who walk
    K Yaffe
    University of California, San Francisco, Campus Box 111G, 4150 Clement St, San Francisco, CA 94121, USA
    Arch Intern Med 161:1703-8. 2001
    ..We determined whether physical activity is associated with cognitive decline in a prospective study of older women...
  83. pmc Vascular basis for brain degeneration: faltering controls and risk factors for dementia
    Raj N Kalaria
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Nutr Rev 68:S74-87. 2010
    ..Lifestyle measures that maintain or improve cardiovascular health, including consumption of healthy diets, moderate use of alcohol, and implementation of regular physical exercise are important factors for brain protection...
  84. ncbi Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
    Oskar Hansson
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
    Lancet Neurol 5:228-34. 2006
    ..Here, we assess the association between CSF biomarkers and incipient Alzheimer's in patients with mild cognitive impairment (MCI)...
  85. ncbi Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats
    Wayne B Rowe
    Department of Functional Neuroscience, Memory Pharmaceuticals Corporation, Montvale, New Jersey 07645, USA
    J Neurosci 27:3098-110. 2007
    ..Together, the findings suggest a new model, in which deficient neuroenergetics leads to downregulated neuronal signaling and increased glial activation, resulting in aging-related cognitive dysfunction...
  86. ncbi Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus
    Yanjie Wan
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London
    Anesthesiology 106:436-43. 2007
    ..The authors investigated the role of cytokine-mediated inflammation within the central nervous system in the development of cognitive dysfunction in a rat model...
  87. pmc Vitamin D and risk of cognitive decline in elderly persons
    David J Llewellyn
    Public Health and Epidemiology Group, Peninsula Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, England
    Arch Intern Med 170:1135-41. 2010
    ..To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia...
  88. ncbi Theory of mind in schizophrenia: meta-analysis
    Mirjam Sprong
    Department of Child and Adolescent Psychiatry, University Medical Centre, Heidelberglaan 100, HPA01 468, 3508 GA Utrecht, The Netherlands
    Br J Psychiatry 191:5-13. 2007
    ..Mentalising impairment (an impaired ability to think about people in terms of their mental states) has frequently been associated with schizophrenia...
  89. ncbi Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis
    Kim A Celone
    Memory Disorders Unit, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:10222-31. 2006
    ..These data may also provide functional evidence of the interaction between neocortical and medial temporal lobe pathology in early AD...
  90. pmc Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment
    Inga Kadish
    Department of Cell Biology, University of Alabama, Birmingham, Alabama 35294, USA
    J Neurosci 29:1805-16. 2009
    ..These processes may damage structure and compete with neuronal pathways for bioenergetic resources, thereby impairing cognitive function...
  91. ncbi Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity
    T S Benice
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, 97239, USA
    Neuroscience 137:413-23. 2006
    ..Elevated levels of microtubule-associated protein 2 and synaptophysin may constitute a compensatory response to age-related functional decline in mice...
  92. ncbi Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis
    Michael J Strong
    Department of Clinical Neurological Sciences, The University of Western Ontario, London, Ontario, Canada
    Amyotroph Lateral Scler 10:131-46. 2009
  93. ncbi Silent brain infarcts and the risk of dementia and cognitive decline
    Sarah E Vermeer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    N Engl J Med 348:1215-22. 2003
    ..Silent brain infarcts are frequently seen on magnetic resonance imaging (MRI) in healthy elderly people and may be associated with dementia and cognitive decline...
  94. ncbi Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients
    L S Rasmussen
    Department of Anaesthesia, Center of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Anaesthesiol Scand 47:260-6. 2003
    ..We hypothesized that the incidence of POCD would be less with regional anaesthesia rather than general...
  95. pmc Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
    Clifford R Jack
    Clifford R Jack, Mayo Clinic, Diagnostic Radiology, 200 First Street SW, Rochester, MN 55905, USA
    Brain 132:1355-65. 2009
    ..This model implies a complimentary role for MRI and PIB imaging in Alzheimer's disease, with each reflecting one of the major pathologies, amyloid dysmetabolism and neurodegeneration...
  96. pmc Comparing predictors of conversion and decline in mild cognitive impairment
    S M Landau
    Helen Wills Neuroscience Institute, University of California, Berkeley 94720 3190, USA
    Neurology 75:230-8. 2010
    ..The goal of this study was to evaluate the prognostic ability of genetic, CSF, neuroimaging, and cognitive measurements obtained in the same participants...
  97. ncbi Dynamics of gray matter loss in Alzheimer's disease
    Paul M Thompson
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1769, USA
    J Neurosci 23:994-1005. 2003
    ..This degenerative sequence, observed in vivo as it developed, provides the first quantitative, dynamic visualization of cortical atrophic rates in normal elderly populations and in those with dementia...
  98. pmc Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease
    John C Morris
    Alzheimer s Disease Research Center, St Louis, Missouri 63108, USA
    Arch Neurol 66:1469-75. 2009
    ..To determine whether preclinical Alzheimer disease (AD), as detected by the amyloid-imaging agent Pittsburgh Compound B (PiB) in cognitively normal older adults, is associated with risk of symptomatic AD...
  99. pmc Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET)
    M J de Leon
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 98:10966-71. 2001
    ..Further study is required to estimate individual risks and to determine the physiologic basis for METglu changes detected while cognition is normal...
  100. pmc Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study
    A Okello
    Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, UK
    Neurology 73:754-60. 2009
    ..Patients with amnestic mild cognitive impairment (MCI) represent an important clinical group as they are at increased risk of developing Alzheimer disease (AD). (11)C-PIB PET is an in vivo marker of brain amyloid load...
  101. pmc Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort
    Shannon L Risacher
    IU Center for Neuroimaging, Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
    Curr Alzheimer Res 6:347-61. 2009
    ..Validation of imaging biomarkers is important as they can help enrich clinical trials of disease modifying agents by identifying individuals at highest risk for progression to AD...

Research Grants92

  1. Pimozide Augmentation of Clozapine in Schizophrenia
    Joseph Friedman; Fiscal Year: 2007
    ..This study will provide sorely needed controlled data on the efficacy and safety of a clozapine combination treatment strategy involving adjunctive antipsychotic agents. [unreadable] [unreadable]..
  2. Effectiveness Trial of Attention Shaping for Schizophrenia
    Steven M Silverstein; Fiscal Year: 2010
  3. Anti-Adenosine Therapy of Neonatal Brain Injury
    Scott Rivkees; Fiscal Year: 2007
    ..It is anticipated that these studies will lead to novel and practical strategies for directly preventing brain injury. [unreadable] [unreadable]..
    Mary Ganguli; Fiscal Year: 2002
  5. Stress Reactivity & Protective Factors in Schizophrenia
    Joseph Ventura; Fiscal Year: 2003
    ..abstract_text> ..
  6. Exploring the role of the central amygdala in vocalization
    IAN CHRISTOPHER HALL; Fiscal Year: 2013
    ..could make important contributions to the treatment of communication disorders, such as speech aphasias, selective mutism, and stuttering, and social cognition disorders, such as Asperger's syndrome and autism spectrum disorders.
  7. Joint Action Analysis of Poly-drug Withdrawal
    Robert Raffa; Fiscal Year: 2006
    ..g., electrophysiologic or molecular biology techniques. An improved understanding of how withdrawal is influenced by poly-drug abuse could lead to development of enhanced clinical treatment. ..
  8. Assessing social-cognitive deficits in schizophrenia.
    Shaun Eack; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Course of Functional Deficits in Late-Life Schizophrenia
    Philip Harvey; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  10. Neurobiologic Study of Psychological Distress & Dementia
    Robert S Wilson; Fiscal Year: 2010
    Mary Ganguli; Fiscal Year: 2003
    ..They will also assist in formulating appropriate policies and guidelines for early diagnosis, treatment, and prevention of excess disability. ..
  12. Clinical Ratings of Neurocognition (CRON)
    Joseph Ventura; Fiscal Year: 2007
    ..The proposed developments are urgently needed to continue the momentum established by the MATRICS initiative, and facilitate regulatory acceptance and clinical awareness of new treatments for CIAS. [unreadable] [unreadable] [unreadable]..
  13. Alzheimer's Diagnosis by Real-Time Motion Corrected FMRI
    Clifford Jack; Fiscal Year: 2004
    ..Aim number 4: to assess motion corrected fMRI as a diagnostic test for early Alzheimer's disease. ..
  14. Effects of Aging on Executive Processes
    Timothy Salthouse; Fiscal Year: 2006
    ..e., specific to individual variables or common to many variables) at which age-related influences operate on executive process variables. ..
    Keith Nuechterlein; Fiscal Year: 2006
    ..These goals will be addressed through data collection with schizophrenic probands and their first-degree relatives as well as with demographically matched community controls and their first-degree relatives. ..
  16. Sex Hormones, Related Polymorphisms & Cognitive Decline
    Kristine Yaffe; Fiscal Year: 2006
    ..Further knowledge of the association between sex hormones, hormone-related polymorphisms and cognitive decline may facilitate preventative strategies to maintain independence and to promote optimum brain aging. ..
  17. Medication Adherence Among Bipolar Patients with Comorbid HIV Infection
    David Moore; Fiscal Year: 2008
    ..More generally, the present study will provide useful information on the treatment of other chronic medical illnesses that may co-occur among patients with bipolar disorder. [unreadable] [unreadable] [unreadable] [unreadable]..
  18. Naturalistic Assessment of the Driving ability of Cognitively Impaired Elders
    BRIAN RICHARD OTT; Fiscal Year: 2010
  19. COMT genotype and response to cognitive remediation in schizophrenia
    Jean Pierre Lindenmayer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
    Keith H Nuechterlein; Fiscal Year: 2010
    ..Potential predictors of response to these treatments will be evaluated. ..
  21. Measuring Striatal Neurotransmission in Behaving Rats after Experimental TBI
    Amy Wagner; Fiscal Year: 2008
    ..The overarching goal is to gain insight into potential mechanisms of action and efficacy of these interventions on cognition and recovery for the clinical population with TBI. [unreadable] [unreadable] [unreadable]..
  22. Dopamine Genetic Variants Modulating Recovery After TBI
    Amy Wagner; Fiscal Year: 2008
    ..Through neurolmaging, we hope to better understand how genetics Influences who may benefit from a relevant rehabilitation-based pharmacological treatment strategy. [unreadable] [unreadable] [unreadable]..
    Michael F Green; Fiscal Year: 2010
  24. Brain Activation in Patients with Early HIV Dementia
    Linda Chang; Fiscal Year: 2008
    ..g. neuroprotective or anti-inflammatory treatments). [unreadable] [unreadable] [unreadable]..
  25. Neurocognitive Function in Children with Hypertension
    MARC LANDE; Fiscal Year: 2008
    ..The effect of antihypertensive therapy on neurocognitive function will be determined. ..
  26. Early brain development after prenatal "Ice" exposure: A Longitudinal MR study
    Linda Chang; Fiscal Year: 2009
    ..Detailed maternal drug use, psychosocial and mood evaluations will be performed and correlated with biological brain changes in these children. ..
    Suzanne de la Monte; Fiscal Year: 2008
    ..abstract_text> ..
  28. Dopamine Function in TBI--Therapeutic Intervention
    Amy Wagner; Fiscal Year: 2005
    ..The Departments of Physical Medicine and Rehabilitation, Neurosurgery, Anesthesia/Critical Care Medicine, and Safar Center for Resuscitation Research provide the environment for this study of experimental and clinical brain injury. ..
    Linda Chang; Fiscal Year: 2001
    ..This comprehensive approach will allow us to determine the relationship between changes in cognitive function and metabolite changes in brain tissue associated with chronic methamphetamine abuse and treatment. ..
  30. Gender Differences in Dopamine Function after TBI
    Amy Wagner; Fiscal Year: 2003
  31. Cognitive Effects of Cancer Chemotherapy
    Tim Ahles; Fiscal Year: 2005 at diagnosis), and use of tamoxifen (breast cancer only). ..
    Keith Nuechterlein; Fiscal Year: 2004
    ..D.s and the other half Ph.D.s. Trainees will be assigned to primary and secondary mentors who will supervise their training activities in an individualized research mentorship model. ..
  33. Metabolic Syndrome and Cognitive Impairment
    Kristine Yaffe; Fiscal Year: 2005
    ..If elders with metabolic syndrome have increased risk of developing cognitive impairment, this would have important clinical and public health significance. ..
    Kristine Yaffe; Fiscal Year: 2002
    ..This award will foster the applicant's development towards becoming an independent investigator in aging research. ..
  35. Vitamin B12 Status of Elderly Americans
    MARTHA MORRIS; Fiscal Year: 2003
    ..The third aim is to evaluate the usefulness of a serum vitamin B12 cut-off point of 258 pmol/L, either as the sole indicator of vitamin B12 deficiency in the elderly, or in conjunction with anemia or an elevated metabolite level. ..
    David Lewis; Fiscal Year: 2004
    Daniel Javitt; Fiscal Year: 2003
    ..The study will provide new information on the efficacy of d-cycloserine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
  38. Measurement & Prediction of Everyday Function Dementia
    Sarah Tomaszewski Farias; Fiscal Year: 2007
    ..Measures of disability and preliminary assessment of handicap will also be included to examine the relationship between the different levels functional change set forth in the model. ..
  39. Effects of Vascular Disease in Mild Cognitive Impairment
    Patricia Boyle; Fiscal Year: 2008
  40. Tobacco Smoking, Nicotine and Negative Affect Relief
    Kenneth Perkins; Fiscal Year: 2009
    ..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
  41. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2009
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  42. Effect of Tai Chi on Osteoarthritic Knee Pain in Elders with Mild Dementia
    Pao Feng Tsai; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. Vascular and Inflammatory Predictors of MCI Risk and Progression
    ROSEBUD ROBERTS; Fiscal Year: 2008
    ..The K01 award will culminate in an R01 application that will pave the way for the candidate to become an independent investigator in MCI and AD research. [unreadable] [unreadable] [unreadable]..
  44. Cell Cycle and COX-2 in a Mouse Model of Alzheimer's
    Giulio Pasinetti; Fiscal Year: 2004
    Gregory Holmes; Fiscal Year: 2002
    ..Results of this study should provide additional insights into our understanding of the long- term consequences of seizures on the developing brain. ..
    Thomas McAllister; Fiscal Year: 2003
    ..Performance and fMRI visualized activation of WM circuitry will be characterized at baseline (on placebo) and following administration of a dopamine agonist. ..
  47. Progression of Dementia: A Population Study
    JOANN T contact TSCHANZ; Fiscal Year: 2010
    ..At CC-DPS completion, we will 1) advance understanding of dementia progression and prognosis;2) discover factors that modify its course;and 3) identify potential new avenues for effective interventions. ..
  48. Role of macrophages in HIV Lipoatrophy
    Cecilia M Shikuma; Fiscal Year: 2010
    ..We are particularly well suited to undertake these studies as our research team combines clinical research expertise in HIV lipoatrophy with specific laboratory competency in adipose tissue-, mitochondrial- and M/MO-related research. ..
  49. Dopamine Systems and Neuropsychiatric Changes in HIV/AIDS
    Benjamin B Gelman; Fiscal Year: 2010
    ..The project breaks ground neuroscientifically, as no autopsy study has advanced to a "task specific" behavioral correlation with circuit level anomalies of a specific neurotransmitter system. ..
  50. Early Life Infection, Neuroinflammation, and Memory
    Staci D Bilbo; Fiscal Year: 2010
    Giulio Pasinetti; Fiscal Year: 2002
    ..Further characterization of the complex role of complement proteins in neurodegeneration is essential especially in view of the possibility that the complement system represents a target for therapeutic interventions in AD. ..
  52. Visuospatial Function in Parkinson's Disease
    ALICE M CRONIN GOLOMB; Fiscal Year: 2010
    ..Demonstration of different profiles of performance in LPD and RPD would bolster arguments of selective visuospatial deficits in PD and suggest differential visual, cognitive, and functional enhancement strategies. ..
  53. Role of COX-2 Gene Expression in Ischemic Brain Damage
    Costantino Iadecola; Fiscal Year: 2010
    ..abstract_text> ..
  54. EEG Abnormalities and Cognitive Impairment
    Gregory L Holmes; Fiscal Year: 2010
    ..In addition to learning much about the cognitive impairment in epilepsy, our studies will provide enormous insight into processes involved in normal encoding and consolidation of memory. ..
    Daeyeol Lee; Fiscal Year: 2009
    ..The results from these experiments will provide a novel insight into the brain mechanisms underlying the organization of sequential behavior ..
  56. Center for Healthy Minds
    Denise Park; Fiscal Year: 2008
    ..abstract_text> ..
  57. Cholinergic Effects on Inhibition and Delay in ADHD
    Alexandra Potter; Fiscal Year: 2005
    ..abstract_text> ..
  58. Predictors of Seizure-Induced Memory Impairment
    Gregory Holmes; Fiscal Year: 2007
    ..Taken together these studies will provide insight into the mechanisms of seizure-induced cognitive dysfunction which will be critical as we attempt to develop novel therapeutic interventions. ..
  59. Dynamics of Cortical Communication
    Daeyeol Lee; Fiscal Year: 2006
    ..The outcome of this research will advance our understanding on how the flow of behaviorally relevant information is regulated across a broad network of cortical neurons. ..
  60. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  61. Alzheimer's Disease in Down Syndrome: Antioxidant Trial
    Ira Lott; Fiscal Year: 2005
    ..The pilot trial should also contribute information as to the possible role of antioxidants in the treatment or prevention of AD in the general population. ..
  62. Global vs. Focal Neuroimaging Markers of Dementia Risk
    Caterina Rosano; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. The VETSA Longitudinal Twin Study of Cortisol and Aging
    William Kremen; Fiscal Year: 2007
    ..Using multivariate twin analytic approaches, we will determine the extent of genetic, and shared and unique environmental factors influencing cortisol in midlife as well as their association with other key measures. ..
  64. Pinitol a Natural Extract from Pine Cones and Alzheimer's Disease
    Giulio Pasinetti; Fiscal Year: 2006
    ..abstract_text> ..
    Jeanne Mandelblatt; Fiscal Year: 2005
    ..Interventions derived from this project, hold the promise of improving the quality of care for the fastest growing segment of the breast cancer population. ..
  66. Improving informed consent in Alzheimer disease research
    Jason Karlawish; Fiscal Year: 2006
    ..The results will also begin to elucidate how experts make judgments of competency. [unreadable] [unreadable] [unreadable]..
  67. Effects of Botanicals on Cognition in Midlife Women
    Pauline Maki; Fiscal Year: 2005
    ..Recent findings of significant health risks associated with Prempro heighten the need for research into the effects of alternative therapies for menopausal symptoms on cognitive outcomes. ..
  68. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  69. Control Trial of Self-Help for Dually-Diagnosed Persons
    Stephen Magura; Fiscal Year: 2005
    ..5. To conduct a process evaluation focusing on the implementation and on-going growth and development of the DTR groups (in the study clinics), as well as DTR group climate. ..
  70. Vascular Depression and Function in Older Latinos
    HECTOR GONZALEZ; Fiscal Year: 2007
    ..abstract_text> ..
  71. Exposure to Immunosuppressive Drugs & Cancer Risk in SLE
    Rosalind Ramsey Goldman; Fiscal Year: 2005
    ..If certain ISDs are linked to cancer risk, prescribing patterns may change. This study may also provide new information about potential links between cancer and autoimmunity. ..
  72. Measurement of folate in fortified cereal grain products
    Jacob Selhub; Fiscal Year: 2003
    ..In order to assess the impact of folic acid fortification, it is necessary to have valid data on the actual synthetic folic acid content of fortified foods. ..
  73. Disclosure of Genetic Risk for Alzheimer's Disease
    Scott Roberts; Fiscal Year: 2007
    ..g., race, provider profession). Study findings will inform the development and implementation of genetic risk assessment programs across numerous disease contexts. [unreadable] [unreadable] [unreadable]..
  74. NeuroAIDS in Cameroon: Molecular determinants
    GEORGETTE KANMOGNE; Fiscal Year: 2008
    ..It will provide knowledge on the epidemiology of neuroAIDS in Cameroon and build the capacity for future neuroAIDS research and therapeutic testing in Cameroon. [unreadable] [unreadable] [unreadable]..
    Silvia Martins; Fiscal Year: 2006
    ..Finally, we believe that our study will bring public health contributions to better understand potential determinants of ecstasy use. [unreadable] [unreadable]..
  76. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
  77. Vaccine therapy of congenital adrenal Hyperplasia
    Scott Rivkees; Fiscal Year: 2003
    ..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism. ..
  78. A Telephone Intervention for Dementia Caregivers
    Geoffrey Tremont; Fiscal Year: 2004
    ..It is hypothesized that the intervention will result in reduced caregiver burden and emotional distress, as well as improved quality of life and family functioning and increased use of community resources. ..
  79. Eighth Cooley's Anemia Symposium
    Elliott Vichinsky; Fiscal Year: 2005
  80. The Role of Feedback to Facilitate Category Learning
    Deborah Little; Fiscal Year: 2005
    ..Finally, we propose to collect pilot data functional MRI data, on the conditions under which prefrontal cortex is implicated during prototype-distortion learning in response to feedback. ..
  81. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2008
    ..unreadable] [unreadable]..
    Susan Waisbren; Fiscal Year: 2006
    ..Primary data from parent interviews and the New England Newborn Screening Program, as well as secondary data from published reports and a panel of experts will be used as inputs to the cost-effectiveness model. [unreadable] [unreadable]..
  83. Effects of Neighborhood SES on Coronary Heart Disease Burden in Communities
    Kathryn Rose; Fiscal Year: 2008
    ..Furthermore, the findings could be used to plan targeted public health interventions aimed at reducing CHD disparities. [unreadable] [unreadable]..
  84. Recall and Survivor Bias: Impact on SES-CVD Associations
    Kathryn Rose; Fiscal Year: 2009
  85. Combat Stress and Cardiovascular Risk Among Aging Men
    Kathryn Rose; Fiscal Year: 2007
    ..Furthermore, they may provide data useful in planning public health intervention programs which target active service and veteran populations. [unreadable] [unreadable]..
  86. Anatomical correlates of executive function decline in normal aging.
    Deborah Little; Fiscal Year: 2008
    ..Additionally, we propose to differentiate short from long white matter fibers to better address the relationship between white matter integrity and cognitive aging. [unreadable] [unreadable] [unreadable]..
  87. Alzheimer Screening in Primary Care: PRISM-PC Study
    Malaz Boustani; Fiscal Year: 2009
    ..Future directions: We anticipate that participants'responses could guide the design of specific counseling and educational interventions to overcome a patients'reluctance to accept dementia screening. ..
  88. Cellular Tropism & Reservoir in Brain with HIV-Clade C
    Avindra Nath; Fiscal Year: 2004
    ..We believe this will serve as a nidus for the development of several projects to address the neuropathogenesis of HIV infection and develop a rational design for therapeutic approaches and vaccine development. ..
  89. Emotion in Dementia
    Howard Rosen; Fiscal Year: 2004