Genomes and Genes
Summary: Disturbances in the mental process related to thinking, reasoning, and judgment.
Publications309 found, 100 shown here
- When does age-related cognitive decline begin?Timothy A Salthouse
Department of Psychology, University of Virginia, Charlottesville, VA 22904 4400, USA
Neurobiol Aging 30:507-14. 2009....
- Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relativesEmre Bora
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Vic, Australia
J Affect Disord 113:1-20. 2009..Our aim was to delineate neuropsychological deficits related to genetic susceptibility, illness process and iatrogenic factors in bipolar disorder (BD)...
- Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?Terry E Goldberg
Zucker Hillside Hospital, 7559 263rd Street, Glen Oaks, NY 11004, USA
Arch Gen Psychiatry 64:1115-22. 2007..However, none of these studies included healthy controls undergoing repeated testing to assess the possibility that improvements might reflect simple practice effects...
- Updated research nosology for HIV-associated neurocognitive disordersA Antinori
Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Instituto di Ricovero e Cura a Carattere Scientifico IRCCS, Rome, Italy
Neurology 69:1789-99. 2007..An algorithm is proposed to assist in standardized diagnostic classification of HAND...
- Selective changes of resting-state networks in individuals at risk for Alzheimer's diseaseChristian Sorg
Department of Psychiatry, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
Proc Natl Acad Sci U S A 104:18760-5. 2007..We interpret our finding as a proof of principle, demonstrating that functional brain disorders can be characterized by functional-disconnectivity profiles of RSNs...
- The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairmentZiad S Nasreddine
Center for Clinical Research, Neurology Service, Hopital Charles LeMoyne, Quebec, Canada
J Am Geriatr Soc 53:695-9. 2005..To develop a 10-minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first-line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia...
- Mild cognitive impairment as a diagnostic entityR C Petersen
Department of Neurology, Alzheimer s Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN, USA
J Intern Med 256:183-94. 2004..By refining the criteria for MCI, clinical trials can be designed with appropriate inclusion and exclusion restrictions to allow for the investigation of therapeutics tailored for specific targets and populations...
- HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER StudyR K Heaton
University of California, San Diego, USA
Neurology 75:2087-96. 2010....
- Current concepts in mild cognitive impairmentR C Petersen
Department of Neurology, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
Arch Neurol 58:1985-92. 2001..While no treatments are recommended for MCI currently, clinical trials regarding potential therapies are under way. Recommendations concerning ethical issues in the diagnosis and the management of subjects with MCI were made...
- The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysisStephanie Debette
Clinical Neuroscience, St George s University of London, London
BMJ 341:c3666. 2010..To review the evidence for an association of white matter hyperintensities with risk of stroke, cognitive decline, dementia, and death...
- What is cognitive reserve? Theory and research application of the reserve conceptYaakov Stern
G H Sergievsky Center, The Taub Institute, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Int Neuropsychol Soc 8:448-60. 2002..Epidemiologic and imaging data that help to develop and support the concept of reserve are presented...
- Cognitive dysfunction in HIV patients despite long-standing suppression of viremiaSamanta Simioni
Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
AIDS 24:1243-50. 2010..To determine the prevalence of cognitive complaints and HIV-associated neurocognitive disorders (HANDs) in a cohort of aviremic HIV-positive patients. To evaluate the relevance of the HIV dementia scale to detect HANDs...
- Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive ImpairmentB Winblad
Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
J Intern Med 256:240-6. 2004....
- Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjectsLeslie M Shaw
Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Ann Neurol 65:403-13. 2009..Develop a cerebrospinal fluid biomarker signature for mild Alzheimer's disease (AD) in Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects...
- The adaptive brain: aging and neurocognitive scaffoldingDenise C Park
The Center for Brain Health, University of Texas at Dallas, Dallas, Texas 75235, USA
Annu Rev Psychol 60:173-96. 2009..Scaffolding is protective of cognitive function in the aging brain, and available evidence suggests that the ability to use this mechanism is strengthened by cognitive engagement, exercise, and low levels of default network engagement...
- A new rating scale for age-related white matter changes applicable to MRI and CTL O Wahlund
Department of Clinical Neuroscience, Neurotec, Karolinska Institutet at Huddinge University Hospital, Huddinge, Sweden
Stroke 32:1318-22. 2001..We have developed and evaluated a new scale and studied ARWMC in a large number of patients examined with both MRI and CT...
- Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young miceRadoslaw Rola
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
Exp Neurol 188:316-30. 2004..These data provide evidence that irradiation of young animals induces a long-term impairment of SGZ neurogenesis that is associated with hippocampal-dependent memory deficits...
- Cerebrospinal fluid and plasma biomarkers in Alzheimer diseaseKaj Blennow
Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, SE 431 80 Molndal, Sweden
Nat Rev Neurol 6:131-44. 2010..Furthermore, we outline the roles of CSF biomarkers in drug discovery and clinical trials, and provide perspectives on AD biomarker discovery and the validation of such markers for use in the clinic...
- The weak coherence account: detail-focused cognitive style in autism spectrum disordersFrancesca Happe
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
J Autism Dev Disord 36:5-25. 2006..Local bias appears not to be a mere side-effect of executive dysfunction, and may be independent of theory of mind deficits. Possible computational and neural models are discussed...
- Neurocognitive deficit in schizophrenia: a quantitative review of the evidenceR W Heinrichs
Department of Psychology, York University, Toronto, Ontario, Canada
Neuropsychology 12:426-45. 1998..The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests...
- CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairmentNiklas Mattsson
Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
JAMA 302:385-93. 2009....
- Role of interleukin-1beta in postoperative cognitive dysfunctionMario Cibelli
Department of Anesthetics, Pain Medicine, and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
Ann Neurol 68:360-8. 2010..We explored whether systemic inflammation, in response to surgical trauma, triggers hippocampal inflammation and subsequent memory impairment, in a mouse model of orthopedic surgery...
- Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesisJacob Raber
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, 97239, USA
Radiat Res 162:39-47. 2004..The significant loss of proliferating SGZ cells and their progeny suggests a contributory role of reduced neurogenesis in the pathogenesis of radiation-induced cognitive impairments...
- Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight childrenCornelieke Sandrine Hanan Aarnoudse-Moens
Division of Neonatology, Department of Pediatrics, Erasmus University Medical Centre Sophia Children s Hospital, Rotterdam, Netherlands
Pediatrics 124:717-28. 2009..We conducted a quantitative meta-analysis of studies published between 1998 and 2008 on academic achievement, behavioral functioning, and EF with the aim of providing aggregated measures of effect size for these outcome domains...
- Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic reviewErik G Willcutt
Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
Biol Psychiatry 57:1336-46. 2005..Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD...
- Predictors of cognitive dysfunction after major noncardiac surgeryTerri G Monk
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, 27705, USA
Anesthesiology 108:18-30. 2008....
- Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's diseaseJorge J Palop
Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
Neuron 55:697-711. 2007..Aberrant increases in network excitability and compensatory inhibitory mechanisms in the hippocampus may contribute to Abeta-induced neurological deficits in hAPP mice and, possibly, also in humans with AD...
- Neural mechanisms of ageing and cognitive declineNicholas A Bishop
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 464:529-35. 2010..Recent advances in the biology of ageing in model organisms, together with molecular and systems-level studies of the brain, are beginning to shed light on these mechanisms and their potential roles in cognitive decline...
- A meta-analysis of cognitive remediation in schizophreniaSusan R McGurk
Dartmouth Psychiatric Research Center, 105 Pleasant Street, Concord, NH 03301, USA
Am J Psychiatry 164:1791-802. 2007..This study evaluated the effects of cognitive remediation for improving cognitive performance, symptoms, and psychosocial functioning in schizophrenia...
- Cognitive deficit in 7-year-old children with prenatal exposure to methylmercuryP Grandjean
Institute of Community Health, Odense University, Denmark
Neurotoxicol Teratol 19:417-28. 1997..The effects on brain function associated with prenatal methylmercury exposure therefore appear widespread, and early dysfunction is detectable at exposure levels currently considered safe...
- Cognitive deficits in depression: possible implications for functional neuropathologyM P Austin
Mood Disorders Unit and Department of Liaison Psychiatry, Prince of Wales Hospital, Sydney, Australia
Br J Psychiatry 178:200-6. 2001..While depression is known to involve a disturbance of mood, movement and cognition, its associated cognitive deficits are frequently viewed as simple epiphenomena of the disorder...
- The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validityC Randolph
Department of Neurology, Loyola University Medical Center, Maywood, IL, USA
J Clin Exp Neuropsychol 20:310-9. 1998..These data suggest that the RBANS is effective at both detecting and characterizing dementia of different etiologies...
- Long-term consequences of postoperative cognitive dysfunctionJacob Steinmetz
Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Anesthesiology 110:548-55. 2009..Postoperative cognitive dysfunction (POCD) is common in elderly patients after noncardiac surgery, but the consequences are unknown. The authors' aim was to determine the effects of POCD on long-term prognosis...
- Mild cognitive impairmentSerge Gauthier
McGill Center for Studies in Aging, Douglas Hospital, Montreal, Quebec, Canada
Lancet 367:1262-70. 2006..Other definitions and subtypes of mild cognitive impairment need to be studied as potential prodromes of Alzheimer's disease and other types of dementia...
- Altered functional connectivity in early Alzheimer's disease: a resting-state fMRI studyKun Wang
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, People s Republic of China
Hum Brain Mapp 28:967-78. 2007..In addition, the results also suggest that AD may disturb the correlation/anti-correlation effect in the two intrinsically anti-correlated networks...
- Long-term effects of cognitive training on everyday functional outcomes in older adultsSherry L Willis
Department of Human Development and Family Studies, Pennsylvania State University, State College, PA 16801
JAMA 296:2805-14. 2006..Cognitive training has been shown to improve cognitive abilities in older adults but the effects of cognitive training on everyday function have not been demonstrated...
- Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive declineNiccolò Terrando
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
Proc Natl Acad Sci U S A 107:20518-22. 2010..Taken together, our results suggest a unique therapeutic potential for preemptive treatment with anti-TNF antibody to prevent surgery-induced cognitive decline...
- Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health studyConstantine G Lyketsos
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
JAMA 288:1475-83. 2002..Dementia and MCI are associated with neuropsychiatric symptoms in clinical samples. Only 2 population-based studies exist of the prevalence of these symptoms in dementia, and none exist for MCI...
- Systematic review: factors associated with risk for and possible prevention of cognitive decline in later lifeBrenda L Plassman
Duke University Medical Center, Durham, North Carolina 27701, USA
Ann Intern Med 153:182-93. 2010..Many biological, behavioral, social, and environmental factors may contribute to the delay or prevention of cognitive decline...
- Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled studyHenry W Mahncke
Posit Science Corporation, 225 Bush Street, San Francisco, CA 94104, USA
Proc Natl Acad Sci U S A 103:12523-8. 2006..This study demonstrates that intensive, plasticity-engaging training can result in an enhancement of cognitive function in normal mature adults...
- Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studiesKaarin J Anstey
Centre for Mental Health Research, School of Psychology, The Australian National University, Canberra, Australia
Am J Epidemiol 166:367-78. 2007..07, 95% CI: -0.11, -0.03), but the groups were not different regarding risk of vascular dementia or any dementia. The authors concluded that elderly smokers have increased risks of dementia and cognitive decline...
- National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standardsVladimir Hachinski
London Health Sciences Centre, University Campus, London, Ontario, Canada
Stroke 37:2220-41. 2006....
- Clock-drawing: is it the ideal cognitive screening test?K I Shulman
Department of Psychiatry, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Ontario, Canada
Int J Geriatr Psychiatry 15:548-61. 2000..This review aims to synthesize the available evidence and assess the value of this screening test according to well-defined criteria...
- Increased hippocampal activation in mild cognitive impairment compared to normal aging and ADB C Dickerson
Department of Neurology, The Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neurology 65:404-11. 2005..To use fMRI to investigate whether hippocampal and entorhinal activation during learning is altered in the earliest phase of mild cognitive impairment (MCI)...
- PET imaging of amyloid deposition in patients with mild cognitive impairmentAnton Forsberg
Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Stockholm, Sweden
Neurobiol Aging 29:1456-65. 2008..01). The PIB retention in MCI converters was comparable to AD patients (p>0.01). Correlations were observed in the MCI patients between PIB retention and CSF Abeta(1-42), total Tau and episodic memory, respectively...
- Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetesSanne M Manschot
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, P O Box 85500, 3508 GA Utrecht, The Netherlands
Diabetes 55:1106-13. 2006..We conclude that cognitive impairments in patients with type 2 diabetes are not only associated with subcortical ischemic changes in the brain, but also with increased brain atrophy...
- Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trialJoseph F Quinn
Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
JAMA 304:1903-11. 2010..Epidemiological studies suggest that consumption of DHA is associated with a reduced incidence of Alzheimer disease. Animal studies demonstrate that oral intake of DHA reduces Alzheimer-like brain pathology...
- The prevalence and incidence of neurocognitive impairment in the HAART eraKevin R Robertson
Department of Neurology, UNC, Chapel Hill, North Carolina 27599, USA
AIDS 21:1915-21. 2007..The effects of HAART on neurological disease are less well understood. The aim of this study was to assess the prevalence and incidence of neurocognitive impairment in individuals who initiated HAART as part of an AIDS clinical trial...
- Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE TrialRichard S E Keefe
Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
Arch Gen Psychiatry 64:633-47. 2007..The relative effect of the second-generation (atypical) antipsychotic drugs and older agents on neurocognition has not been comprehensively determined...
- Insights into the ageing mind: a view from cognitive neuroscienceTrey Hedden
Stanford University, Psychology Department, 434 Jordan Hall, Building 420, Stanford, California 94305 2130, USA
Nat Rev Neurosci 5:87-96. 2004
- Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI studySerge A R B Rombouts
Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
Hum Brain Mapp 26:231-9. 2005..These findings suggest that altered activity in the default mode network may act as an early marker for AD pathology...
- Mild cognitive impairment: ten years laterRonald C Petersen
Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Arch Neurol 66:1447-55. 2009..This review summarizes the progress that has been made while also recognizing the challenges that remain...
- Prodromal Alzheimer's disease: successive emergence of the clinical symptomsHelene Amieva
Institut National de la Sante et de la Recherche Medicale, U897, France
Ann Neurol 64:492-8. 2008..Utilizing the long follow-up of the PAQUID study, we examined the emergence of the first clinical symptoms over a 14-year period of follow-up before the dementia phase of AD...
- Cognitive impairment in multiple sclerosisNancy D Chiaravalloti
Neuropsychology and Neuroscience Laboratory, Kessler Medical Rehabilitation Research and Education Center, West Orange, NJ 07052, USA
Lancet Neurol 7:1139-51. 2008..Moreover, examination of efforts to treat the cognitive deficits in MS is still in the early stages...
- Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive declineKarin Yurko-Mauro
Clinical Research Department, Martek Biosciences Corporation, Columbia, MD, USA
Alzheimers Dement 6:456-64. 2010..Higher DHA intake is inversely correlated with relative risk of Alzheimer's disease. The potential benefits of DHA supplementation in age-related cognitive decline (ARCD) have not been fully examined...
- The age-dependent relation of blood pressure to cognitive function and dementiaChengxuan Qiu
Aging Research Centre, Division of Geriatric Epidemiology and Medicine, Department of Neurotec, Karolinska Institute and Stockholm Gerontology Research Centre, Stockholm, Sweden
Lancet Neurol 4:487-99. 2005....
- Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implicationsCarol Gregory
Fulbourn Hospital, Cambridge, UK
Brain 125:752-64. 2002..This study supports the hypothesis that patients with fvFTD, but not those with Alzheimer's disease, are impaired on tests of ToM, and may explain some of the abnormalities in interpersonal behaviour that characterize fvFTD...
- Neuropsychiatric and neurodevelopmental outcome of children at age 6 and 7 years who screened positive for language problems at 30 monthsCarmela Miniscalco
Department of Logopedics and Phoniatrics, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Dev Med Child Neurol 48:361-6. 2006..Remaining language problems at age 6 years strongly predict the presence of neuropsychiatric or neurodevelopmental disorders at age 7 years...
- Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activityA Giralt
Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
Hum Mol Genet 21:1203-16. 2012..These findings demonstrate an important role for CBP in cognitive dysfunction in HD and suggest the use of histone deacetylase inhibitors as a novel therapeutic strategy for the treatment of memory deficits in this disease...
- Age-associated cognitive declineIan J Deary
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
Br Med Bull 92:135-52. 2009..The determinants of the differences in age-related cognitive decline are not fully understood. Progress in the field is taking place across many areas of biomedical and psychosocial sciences...
- The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947Ian J Deary
Department of Psychology, University of Edinburgh, Edinburgh, Scotland
J Pers Soc Psychol 86:130-47. 2004....
- Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trialsMichael Grundman
Alzheimer s Disease Cooperative Study, Department of Neurosciences, University of California San Diego, 8950 Villa La Jolla Drive, Suite 227, La Jolla, CA 92037, USA
Arch Neurol 61:59-66. 2004..The Memory Impairment Study (MIS) is a multicenter clinical trial in patients with MCI designed to evaluate whether vitamin E or donepezil is effective at delaying the time to a clinical diagnosis of AD...
- Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohortLi Shen
Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 950 West Walnut Street R2 E124, Indianapolis, IN 46202, USA
Neuroimage 53:1051-63. 2010..A genome-wide, whole brain search strategy has the potential to reveal novel candidate genes and loci warranting further investigation and replication...
- Human immunodeficiency virus-associated neurocognitive disorders: Mind the gapJustin C McArthur
NIMH Center for Novel Therapeutics for HIV Associated Cognitive Disorders, Johns Hopkins University, Baltimore, MD, USA
Ann Neurol 67:699-714. 2010..Novel therapies aimed at persistent central nervous system inflammation will be needed to close this gap...
- Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatmentNicola Canessa
Center for Cognitive Neuroscience, Vita Salute San Raffaele University, Milan, Italy
Am J Respir Crit Care Med 183:1419-26. 2011..Knowledge of the brain structures involved in OSA and the corresponding functional implications could provide clues to the pathogenesis of cognitive impairment and its reversibility in this disorder...
- Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosisDavid J Hawellek
Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
Proc Natl Acad Sci U S A 108:19066-71. 2011....
- A meta-analysis of cognitive deficits in first-episode Major Depressive DisorderRico S C Lee
Department of Psychology, Macquarie University, NSW, Australia
J Affect Disord 140:113-24. 2012..The current aim was to systematically evaluate the literature on first-episode MDD to determine whether cognition may be a feasible target for early identification and intervention...
- Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS)Ralph H B Benedict
State University of New York at Buffalo School of Medicine, Department of Neurology, Division of Departmental and Behavioral Neurosciences, Buffalo, New York, USA
J Int Neuropsychol Soc 12:549-58. 2006..We conclude that the MACFIMS is a valid approach to routine NP assessment of MS patients. Future work is planned to determine its psychometric properties in a longitudinal study...
- Neurocognitive profiles in bipolar I and bipolar II disorder: differences in pattern and magnitude of dysfunctionCarmen Simonsen
Department of Psychiatry, Ulleval University Hospital, and Institute of Psychology, University of Oslo, Oslo, Norway
Bipolar Disord 10:245-55. 2008..The aim of this study was to examine whether patients with bipolar I and bipolar II disorder have different neurocognitive profiles...
- Disconnection as a mechanism for cognitive dysfunction in multiple sclerosisR A Dineen
Department of Academic Radiology, Queen s Medical Centre, University of Nottingham, Nottingham, UK
Brain 132:239-49. 2009..This suggests that TBSS reveals functionally relevant tract injury underlying cognitive dysfunction in patients with multiple sclerosis...
- Elevated body mass index is associated with executive dysfunction in otherwise healthy adultsJohn Gunstad
Department of Psychology, Kent Hall, Kent State University, Kent, OH 44242, USA
Compr Psychiatry 48:57-61. 2007..Further research is needed to identify the etiology of these deficits and whether they resolve after weight loss...
- Identification of separable cognitive factors in schizophreniaKeith H Nuechterlein
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, USA
Schizophr Res 72:29-39. 2004..These separable cognitive dimensions also have broader relevance to future research aimed at understanding the nature and structure of core cognitive deficits in schizophrenia...
- Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's diseaseGeorge Bartzokis
Department of Neurology, UCLA Alzheimer s Disease Center, Los Angeles, CA 90095, USA
Neurobiol Aging 25:5-18; author reply 49-62. 2004....
- White matter damage on diffusion tensor imaging correlates with age-related cognitive declineR A Charlton
Clinical Neuroscience, St George s University of London, UK
Neurology 66:217-22. 2006..Damage to white matter tracts, resulting in "cerebral disconnection," may underlie age-related cognitive decline...
- Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairmentS W Scheff
Sanders Brown Center on Aging and Alzheimer Disease Research Center, University of Kentucky College of Medicine, Lexington, KY 40536 0230, USA
Neurology 68:1501-8. 2007....
- The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validityKeith H Nuechterlein
Department of Psychology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Rm 2251, Los Angeles, CA 90095 6968, USA
Am J Psychiatry 165:203-13. 2008....
- Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's diseaseJeremy M Van Raamsdonk
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3 Canada
J Neurosci 25:4169-80. 2005....
- The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive batteryRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3270, Durham, NC 27710, USA
Schizophr Res 68:283-97. 2004..76) and healthy controls (r=0.90). These psychometric properties make the BACS a promising tool for assessing cognition repeatedly in patients with schizophrenia, especially in clinical trials of cognitive enhancement...
- Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer diseaseY Zhang
MR Unit 114M, VA Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
Neurology 68:13-9. 2007..However, it is unclear whether these abnormalities also impact the cingulum fibers, which connect the medial temporal lobe and the posterior cingulate regions...
- The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studiesInge Klinkenberg
Faculty of Psychology and Neuroscience, EURON, Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands
Neurosci Biobehav Rev 34:1307-50. 2010..The use of muscarinic M1 antagonists is suggested as a more selective and effective way of inducing cholinergic-induced cognitive deficits...
- Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationshipPeter T Nelson
Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging, Lexington, KY 40536 0230, USA
J Neuropathol Exp Neurol 68:1-14. 2009..We argue that existing data strongly support the hypothesis that both amyloid plaques and NFTs contribute to cognitive impairment...
- A prospective study of physical activity and cognitive decline in elderly women: women who walkK Yaffe
University of California, San Francisco, Campus Box 111G, 4150 Clement St, San Francisco, CA 94121, USA
Arch Intern Med 161:1703-8. 2001..We determined whether physical activity is associated with cognitive decline in a prospective study of older women...
- Vascular basis for brain degeneration: faltering controls and risk factors for dementiaRaj N Kalaria
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
Nutr Rev 68:S74-87. 2010..Lifestyle measures that maintain or improve cardiovascular health, including consumption of healthy diets, moderate use of alcohol, and implementation of regular physical exercise are important factors for brain protection...
- Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up studyOskar Hansson
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
Lancet Neurol 5:228-34. 2006..Here, we assess the association between CSF biomarkers and incipient Alzheimer's in patients with mild cognitive impairment (MCI)...
- Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged ratsWayne B Rowe
Department of Functional Neuroscience, Memory Pharmaceuticals Corporation, Montvale, New Jersey 07645, USA
J Neurosci 27:3098-110. 2007..Together, the findings suggest a new model, in which deficient neuroenergetics leads to downregulated neuronal signaling and increased glial activation, resulting in aging-related cognitive dysfunction...
- Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampusYanjie Wan
Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London
Anesthesiology 106:436-43. 2007..The authors investigated the role of cytokine-mediated inflammation within the central nervous system in the development of cognitive dysfunction in a rat model...
- Vitamin D and risk of cognitive decline in elderly personsDavid J Llewellyn
Public Health and Epidemiology Group, Peninsula Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, England
Arch Intern Med 170:1135-41. 2010..To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia...
- Theory of mind in schizophrenia: meta-analysisMirjam Sprong
Department of Child and Adolescent Psychiatry, University Medical Centre, Heidelberglaan 100, HPA01 468, 3508 GA Utrecht, The Netherlands
Br J Psychiatry 191:5-13. 2007..Mentalising impairment (an impaired ability to think about people in terms of their mental states) has frequently been associated with schizophrenia...
- Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysisKim A Celone
Memory Disorders Unit, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 26:10222-31. 2006..These data may also provide functional evidence of the interaction between neocortical and medial temporal lobe pathology in early AD...
- Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairmentInga Kadish
Department of Cell Biology, University of Alabama, Birmingham, Alabama 35294, USA
J Neurosci 29:1805-16. 2009..These processes may damage structure and compete with neuronal pathways for bioenergetic resources, thereby impairing cognitive function...
- Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivityT S Benice
Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, 97239, USA
Neuroscience 137:413-23. 2006..Elevated levels of microtubule-associated protein 2 and synaptophysin may constitute a compensatory response to age-related functional decline in mice...
- Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosisMichael J Strong
Department of Clinical Neurological Sciences, The University of Western Ontario, London, Ontario, Canada
Amyotroph Lateral Scler 10:131-46. 2009....
- Silent brain infarcts and the risk of dementia and cognitive declineSarah E Vermeer
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
N Engl J Med 348:1215-22. 2003..Silent brain infarcts are frequently seen on magnetic resonance imaging (MRI) in healthy elderly people and may be associated with dementia and cognitive decline...
- Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patientsL S Rasmussen
Department of Anaesthesia, Center of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Acta Anaesthesiol Scand 47:260-6. 2003..We hypothesized that the incidence of POCD would be less with regional anaesthesia rather than general...
- Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's diseaseClifford R Jack
Clifford R Jack, Mayo Clinic, Diagnostic Radiology, 200 First Street SW, Rochester, MN 55905, USA
Brain 132:1355-65. 2009..This model implies a complimentary role for MRI and PIB imaging in Alzheimer's disease, with each reflecting one of the major pathologies, amyloid dysmetabolism and neurodegeneration...
- Comparing predictors of conversion and decline in mild cognitive impairmentS M Landau
Helen Wills Neuroscience Institute, University of California, Berkeley 94720 3190, USA
Neurology 75:230-8. 2010..The goal of this study was to evaluate the prognostic ability of genetic, CSF, neuroimaging, and cognitive measurements obtained in the same participants...
- Dynamics of gray matter loss in Alzheimer's diseasePaul M Thompson
Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1769, USA
J Neurosci 23:994-1005. 2003..This degenerative sequence, observed in vivo as it developed, provides the first quantitative, dynamic visualization of cortical atrophic rates in normal elderly populations and in those with dementia...
- Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer diseaseJohn C Morris
Alzheimer s Disease Research Center, St Louis, Missouri 63108, USA
Arch Neurol 66:1469-75. 2009..To determine whether preclinical Alzheimer disease (AD), as detected by the amyloid-imaging agent Pittsburgh Compound B (PiB) in cognitively normal older adults, is associated with risk of symptomatic AD...
- Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose/poitron-emission tomography (FDG/PET)M J de Leon
Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
Proc Natl Acad Sci U S A 98:10966-71. 2001..Further study is required to estimate individual risks and to determine the physiologic basis for METglu changes detected while cognition is normal...
- Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET studyA Okello
Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College London, UK
Neurology 73:754-60. 2009..Patients with amnestic mild cognitive impairment (MCI) represent an important clinical group as they are at increased risk of developing Alzheimer disease (AD). (11)C-PIB PET is an in vivo marker of brain amyloid load...
- Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohortShannon L Risacher
IU Center for Neuroimaging, Division of Imaging Sciences, Department of Radiology, Indiana University School of Medicine, 950 W Walnut St, R2 E124, Indianapolis, IN 46202, USA
Curr Alzheimer Res 6:347-61. 2009..Validation of imaging biomarkers is important as they can help enrich clinical trials of disease modifying agents by identifying individuals at highest risk for progression to AD...
- Pimozide Augmentation of Clozapine in SchizophreniaJoseph Friedman; Fiscal Year: 2007..This study will provide sorely needed controlled data on the efficacy and safety of a clozapine combination treatment strategy involving adjunctive antipsychotic agents. [unreadable] [unreadable]..
- Effectiveness Trial of Attention Shaping for SchizophreniaSteven M Silverstein; Fiscal Year: 2010....
- Anti-Adenosine Therapy of Neonatal Brain InjuryScott Rivkees; Fiscal Year: 2007..It is anticipated that these studies will lead to novel and practical strategies for directly preventing brain injury. [unreadable] [unreadable]..
- EPIDEMIOLOGY OF DEMENTIA: A PROSPECTIVE COMMUNITY STUDYMary Ganguli; Fiscal Year: 2002....
- Stress Reactivity & Protective Factors in SchizophreniaJoseph Ventura; Fiscal Year: 2003..abstract_text> ..
- Exploring the role of the central amygdala in vocalizationIAN CHRISTOPHER HALL; Fiscal Year: 2013..could make important contributions to the treatment of communication disorders, such as speech aphasias, selective mutism, and stuttering, and social cognition disorders, such as Asperger's syndrome and autism spectrum disorders.
- Joint Action Analysis of Poly-drug WithdrawalRobert Raffa; Fiscal Year: 2006..g., electrophysiologic or molecular biology techniques. An improved understanding of how withdrawal is influenced by poly-drug abuse could lead to development of enhanced clinical treatment. ..
- Assessing social-cognitive deficits in schizophrenia.Shaun Eack; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Course of Functional Deficits in Late-Life SchizophreniaPhilip Harvey; Fiscal Year: 2007..unreadable] [unreadable]..
- Neurobiologic Study of Psychological Distress & DementiaRobert S Wilson; Fiscal Year: 2010....
- CLINICAL EPIDEMIOLOGY OF DEMENTIA IN GENERAL PRACTICEMary Ganguli; Fiscal Year: 2003..They will also assist in formulating appropriate policies and guidelines for early diagnosis, treatment, and prevention of excess disability. ..
- Clinical Ratings of Neurocognition (CRON)Joseph Ventura; Fiscal Year: 2007..The proposed developments are urgently needed to continue the momentum established by the MATRICS initiative, and facilitate regulatory acceptance and clinical awareness of new treatments for CIAS. [unreadable] [unreadable] [unreadable]..
- Alzheimer's Diagnosis by Real-Time Motion Corrected FMRIClifford Jack; Fiscal Year: 2004..Aim number 4: to assess motion corrected fMRI as a diagnostic test for early Alzheimer's disease. ..
- Effects of Aging on Executive ProcessesTimothy Salthouse; Fiscal Year: 2006..e., specific to individual variables or common to many variables) at which age-related influences operate on executive process variables. ..
- TRANSMISSION OF VULNERABILITY FACTORS FOR SCHIZOPHRENIAKeith Nuechterlein; Fiscal Year: 2006..These goals will be addressed through data collection with schizophrenic probands and their first-degree relatives as well as with demographically matched community controls and their first-degree relatives. ..
- Sex Hormones, Related Polymorphisms & Cognitive DeclineKristine Yaffe; Fiscal Year: 2006..Further knowledge of the association between sex hormones, hormone-related polymorphisms and cognitive decline may facilitate preventative strategies to maintain independence and to promote optimum brain aging. ..
- Medication Adherence Among Bipolar Patients with Comorbid HIV InfectionDavid Moore; Fiscal Year: 2008..More generally, the present study will provide useful information on the treatment of other chronic medical illnesses that may co-occur among patients with bipolar disorder. [unreadable] [unreadable] [unreadable] [unreadable]..
- Naturalistic Assessment of the Driving ability of Cognitively Impaired EldersBRIAN RICHARD OTT; Fiscal Year: 2010....
- COMT genotype and response to cognitive remediation in schizophreniaJean Pierre Lindenmayer; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- DEVELOPMENTAL PROCESSES IN SCHIZOPHRENIC DISORDERSKeith H Nuechterlein; Fiscal Year: 2010..Potential predictors of response to these treatments will be evaluated. ..
- Measuring Striatal Neurotransmission in Behaving Rats after Experimental TBIAmy Wagner; Fiscal Year: 2008..The overarching goal is to gain insight into potential mechanisms of action and efficacy of these interventions on cognition and recovery for the clinical population with TBI. [unreadable] [unreadable] [unreadable]..
- Dopamine Genetic Variants Modulating Recovery After TBIAmy Wagner; Fiscal Year: 2008..Through neurolmaging, we hope to better understand how genetics Influences who may benefit from a relevant rehabilitation-based pharmacological treatment strategy. [unreadable] [unreadable] [unreadable]..
- EARLY VISUAL PROCESSING IN SCHIZOPHRENIAMichael F Green; Fiscal Year: 2010....
- Brain Activation in Patients with Early HIV DementiaLinda Chang; Fiscal Year: 2008..g. neuroprotective or anti-inflammatory treatments). [unreadable] [unreadable] [unreadable]..
- Neurocognitive Function in Children with HypertensionMARC LANDE; Fiscal Year: 2008..The effect of antihypertensive therapy on neurocognitive function will be determined. ..
- Early brain development after prenatal "Ice" exposure: A Longitudinal MR studyLinda Chang; Fiscal Year: 2009..Detailed maternal drug use, psychosocial and mood evaluations will be performed and correlated with biological brain changes in these children. ..
- ETHANOL, INSULIN/IGF SIGNALING AND NEURONAL MIGRATIONSuzanne de la Monte; Fiscal Year: 2008..abstract_text> ..
- Dopamine Function in TBI--Therapeutic InterventionAmy Wagner; Fiscal Year: 2005..The Departments of Physical Medicine and Rehabilitation, Neurosurgery, Anesthesia/Critical Care Medicine, and Safar Center for Resuscitation Research provide the environment for this study of experimental and clinical brain injury. ..
- MONITORING METHAMPHETAMINE ABUSE TREATMENT WITH 1H MRSLinda Chang; Fiscal Year: 2001..This comprehensive approach will allow us to determine the relationship between changes in cognitive function and metabolite changes in brain tissue associated with chronic methamphetamine abuse and treatment. ..
- Gender Differences in Dopamine Function after TBIAmy Wagner; Fiscal Year: 2003....
- Cognitive Effects of Cancer ChemotherapyTim Ahles; Fiscal Year: 2005..post-menopausal at diagnosis), and use of tamoxifen (breast cancer only). ..
- INTERVENTION RESEARCH TRAINING FOR THE PSYCHOSESKeith Nuechterlein; Fiscal Year: 2004..D.s and the other half Ph.D.s. Trainees will be assigned to primary and secondary mentors who will supervise their training activities in an individualized research mentorship model. ..
- Metabolic Syndrome and Cognitive ImpairmentKristine Yaffe; Fiscal Year: 2005..If elders with metabolic syndrome have increased risk of developing cognitive impairment, this would have important clinical and public health significance. ..
- ESTROGEN COMPOUNDS, COGNITION & DEMENTIA IN OLDER WOMENKristine Yaffe; Fiscal Year: 2002..This award will foster the applicant's development towards becoming an independent investigator in aging research. ..
- Vitamin B12 Status of Elderly AmericansMARTHA MORRIS; Fiscal Year: 2003..The third aim is to evaluate the usefulness of a serum vitamin B12 cut-off point of 258 pmol/L, either as the sole indicator of vitamin B12 deficiency in the elderly, or in conjunction with anemia or an elevated metabolite level. ..
- SCHIZOPHRENIA AND PREFRONTAL CORTICAL CIRCUITRYDavid Lewis; Fiscal Year: 2004....
- TREATMENT OF NEGATIVE SYMPTOMS AND COGNITIVE IMPAIRMENTSDaniel Javitt; Fiscal Year: 2003..The study will provide new information on the efficacy of d-cycloserine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
- Measurement & Prediction of Everyday Function DementiaSarah Tomaszewski Farias; Fiscal Year: 2007..Measures of disability and preliminary assessment of handicap will also be included to examine the relationship between the different levels functional change set forth in the model. ..
- Effects of Vascular Disease in Mild Cognitive ImpairmentPatricia Boyle; Fiscal Year: 2008....
- Tobacco Smoking, Nicotine and Negative Affect ReliefKenneth Perkins; Fiscal Year: 2009..In sum, this research will help address the fundamental question of why cigarette smoking is reinforcing. ..
- Proteomics of Cerebrospinal Fluid in Chronic Fatigue SyndromeJames Baraniuk; Fiscal Year: 2009..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
- Effect of Tai Chi on Osteoarthritic Knee Pain in Elders with Mild DementiaPao Feng Tsai; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Vascular and Inflammatory Predictors of MCI Risk and ProgressionROSEBUD ROBERTS; Fiscal Year: 2008..The K01 award will culminate in an R01 application that will pave the way for the candidate to become an independent investigator in MCI and AD research. [unreadable] [unreadable] [unreadable]..
- Cell Cycle and COX-2 in a Mouse Model of Alzheimer'sGiulio Pasinetti; Fiscal Year: 2004....
- LONG TERM EFFECTS OF SEIZURES ON THE DEVELOPING BRAINGregory Holmes; Fiscal Year: 2002..Results of this study should provide additional insights into our understanding of the long- term consequences of seizures on the developing brain. ..
- DOPAMINERGIC MODULATION WORKING MEMORY TBI--FMRI STUDYThomas McAllister; Fiscal Year: 2003..Performance and fMRI visualized activation of WM circuitry will be characterized at baseline (on placebo) and following administration of a dopamine agonist. ..
- Progression of Dementia: A Population StudyJOANN T contact TSCHANZ; Fiscal Year: 2010..At CC-DPS completion, we will 1) advance understanding of dementia progression and prognosis;2) discover factors that modify its course;and 3) identify potential new avenues for effective interventions. ..
- Role of macrophages in HIV LipoatrophyCecilia M Shikuma; Fiscal Year: 2010..We are particularly well suited to undertake these studies as our research team combines clinical research expertise in HIV lipoatrophy with specific laboratory competency in adipose tissue-, mitochondrial- and M/MO-related research. ..
- Dopamine Systems and Neuropsychiatric Changes in HIV/AIDSBenjamin B Gelman; Fiscal Year: 2010..The project breaks ground neuroscientifically, as no autopsy study has advanced to a "task specific" behavioral correlation with circuit level anomalies of a specific neurotransmitter system. ..
- Early Life Infection, Neuroinflammation, and MemoryStaci D Bilbo; Fiscal Year: 2010....
- COMPLEMENT AND NEUROPROTECTION: ALZHEIMER'S DISEASEGiulio Pasinetti; Fiscal Year: 2002..Further characterization of the complex role of complement proteins in neurodegeneration is essential especially in view of the possibility that the complement system represents a target for therapeutic interventions in AD. ..
- Visuospatial Function in Parkinson's DiseaseALICE M CRONIN GOLOMB; Fiscal Year: 2010..Demonstration of different profiles of performance in LPD and RPD would bolster arguments of selective visuospatial deficits in PD and suggest differential visual, cognitive, and functional enhancement strategies. ..
- Role of COX-2 Gene Expression in Ischemic Brain DamageCostantino Iadecola; Fiscal Year: 2010..abstract_text> ..
- EEG Abnormalities and Cognitive ImpairmentGregory L Holmes; Fiscal Year: 2010..In addition to learning much about the cognitive impairment in epilepsy, our studies will provide enormous insight into processes involved in normal encoding and consolidation of memory. ..
- CORTICAL MECHANISMS OF SEQUENCE LEARNINGDaeyeol Lee; Fiscal Year: 2009..The results from these experiments will provide a novel insight into the brain mechanisms underlying the organization of sequential behavior ..
- Center for Healthy MindsDenise Park; Fiscal Year: 2008..abstract_text> ..
- Cholinergic Effects on Inhibition and Delay in ADHDAlexandra Potter; Fiscal Year: 2005..abstract_text> ..
- Predictors of Seizure-Induced Memory ImpairmentGregory Holmes; Fiscal Year: 2007..Taken together these studies will provide insight into the mechanisms of seizure-induced cognitive dysfunction which will be critical as we attempt to develop novel therapeutic interventions. ..
- Dynamics of Cortical CommunicationDaeyeol Lee; Fiscal Year: 2006..The outcome of this research will advance our understanding on how the flow of behaviorally relevant information is regulated across a broad network of cortical neurons. ..
- Nicotinic-Antipsychotic Drug Interactions and CognitionEdward Levin; Fiscal Year: 2006..abstract_text> ..
- Alzheimer's Disease in Down Syndrome: Antioxidant TrialIra Lott; Fiscal Year: 2005..The pilot trial should also contribute information as to the possible role of antioxidants in the treatment or prevention of AD in the general population. ..
- Global vs. Focal Neuroimaging Markers of Dementia RiskCaterina Rosano; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- The VETSA Longitudinal Twin Study of Cortisol and AgingWilliam Kremen; Fiscal Year: 2007..Using multivariate twin analytic approaches, we will determine the extent of genetic, and shared and unique environmental factors influencing cortisol in midlife as well as their association with other key measures. ..
- Pinitol a Natural Extract from Pine Cones and Alzheimer's DiseaseGiulio Pasinetti; Fiscal Year: 2006..abstract_text> ..
- CHEMOTHERAPY DECISIONS AND OUTCOMES FOR THE ELDERLYJeanne Mandelblatt; Fiscal Year: 2005..Interventions derived from this project, hold the promise of improving the quality of care for the fastest growing segment of the breast cancer population. ..
- Improving informed consent in Alzheimer disease researchJason Karlawish; Fiscal Year: 2006..The results will also begin to elucidate how experts make judgments of competency. [unreadable] [unreadable] [unreadable]..
- Effects of Botanicals on Cognition in Midlife WomenPauline Maki; Fiscal Year: 2005..Recent findings of significant health risks associated with Prempro heighten the need for research into the effects of alternative therapies for menopausal symptoms on cognitive outcomes. ..
- Progestrone and the Effects of NicotineMehmet Sofuoglu; Fiscal Year: 2006..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
- Control Trial of Self-Help for Dually-Diagnosed PersonsStephen Magura; Fiscal Year: 2005..5. To conduct a process evaluation focusing on the implementation and on-going growth and development of the DTR groups (in the study clinics), as well as DTR group climate. ..
- Vascular Depression and Function in Older LatinosHECTOR GONZALEZ; Fiscal Year: 2007..abstract_text> ..
- Exposure to Immunosuppressive Drugs & Cancer Risk in SLERosalind Ramsey Goldman; Fiscal Year: 2005..If certain ISDs are linked to cancer risk, prescribing patterns may change. This study may also provide new information about potential links between cancer and autoimmunity. ..
- Measurement of folate in fortified cereal grain productsJacob Selhub; Fiscal Year: 2003..In order to assess the impact of folic acid fortification, it is necessary to have valid data on the actual synthetic folic acid content of fortified foods. ..
- Disclosure of Genetic Risk for Alzheimer's DiseaseScott Roberts; Fiscal Year: 2007..g., race, provider profession). Study findings will inform the development and implementation of genetic risk assessment programs across numerous disease contexts. [unreadable] [unreadable] [unreadable]..
- NeuroAIDS in Cameroon: Molecular determinantsGEORGETTE KANMOGNE; Fiscal Year: 2008..It will provide knowledge on the epidemiology of neuroAIDS in Cameroon and build the capacity for future neuroAIDS research and therapeutic testing in Cameroon. [unreadable] [unreadable] [unreadable]..
- PREDICTORS OF ADOLESCENT ECSTASY USE IN THE NATIONAL SURVEY OF PARENTS AND YOUTHSilvia Martins; Fiscal Year: 2006..Finally, we believe that our study will bring public health contributions to better understand potential determinants of ecstasy use. [unreadable] [unreadable]..
- CB1 Receptor Action on the Developing HippocampusScott Rivkees; Fiscal Year: 2005..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
- Vaccine therapy of congenital adrenal HyperplasiaScott Rivkees; Fiscal Year: 2003..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism. ..
- A Telephone Intervention for Dementia CaregiversGeoffrey Tremont; Fiscal Year: 2004..It is hypothesized that the intervention will result in reduced caregiver burden and emotional distress, as well as improved quality of life and family functioning and increased use of community resources. ..
- Eighth Cooley's Anemia SymposiumElliott Vichinsky; Fiscal Year: 2005....
- The Role of Feedback to Facilitate Category LearningDeborah Little; Fiscal Year: 2005..Finally, we propose to collect pilot data functional MRI data, on the conditions under which prefrontal cortex is implicated during prototype-distortion learning in response to feedback. ..
- Adolescence: A Sensitive Period for Nicotine AddictionEdward Levin; Fiscal Year: 2008..unreadable] [unreadable]..
- EXPANDED NEWBORN SCREENING FOR METABOLIC DISORDERSSusan Waisbren; Fiscal Year: 2006..Primary data from parent interviews and the New England Newborn Screening Program, as well as secondary data from published reports and a panel of experts will be used as inputs to the cost-effectiveness model. [unreadable] [unreadable]..
- Effects of Neighborhood SES on Coronary Heart Disease Burden in CommunitiesKathryn Rose; Fiscal Year: 2008..Furthermore, the findings could be used to plan targeted public health interventions aimed at reducing CHD disparities. [unreadable] [unreadable]..
- Recall and Survivor Bias: Impact on SES-CVD AssociationsKathryn Rose; Fiscal Year: 2009....
- Combat Stress and Cardiovascular Risk Among Aging MenKathryn Rose; Fiscal Year: 2007..Furthermore, they may provide data useful in planning public health intervention programs which target active service and veteran populations. [unreadable] [unreadable]..
- Anatomical correlates of executive function decline in normal aging.Deborah Little; Fiscal Year: 2008..Additionally, we propose to differentiate short from long white matter fibers to better address the relationship between white matter integrity and cognitive aging. [unreadable] [unreadable] [unreadable]..
- Alzheimer Screening in Primary Care: PRISM-PC StudyMalaz Boustani; Fiscal Year: 2009..Future directions: We anticipate that participants'responses could guide the design of specific counseling and educational interventions to overcome a patients'reluctance to accept dementia screening. ..
- Cellular Tropism & Reservoir in Brain with HIV-Clade CAvindra Nath; Fiscal Year: 2004..We believe this will serve as a nidus for the development of several projects to address the neuropathogenesis of HIV infection and develop a rational design for therapeutic approaches and vaccine development. ..
- Emotion in DementiaHoward Rosen; Fiscal Year: 2004....