mental disorders

Summary

Summary: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.

Top Publications

  1. pmc Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence
    Ilan H Meyer
    Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Psychol Bull 129:674-97. 2003
  2. ncbi The Vietnamese version of the Self Reporting Questionnaire 20 (SRQ-20) in detecting mental disorders in rural Vietnam: a validation study
    Kim Bao Giang
    Faculty of Public Health, Hanoi Medical University, Vietnam
    Int J Soc Psychiatry 52:175-84. 2006
  3. ncbi Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    RNA Biol 6:248-53. 2009
  4. ncbi Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:593-602. 2005
  5. ncbi Short screening scales to monitor population prevalences and trends in non-specific psychological distress
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Psychol Med 32:959-76. 2002
  6. pmc Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:617-27. 2005
  7. doi The size and burden of mental disorders and other disorders of the brain in Europe 2010
    H U Wittchen
    Institute of Clinical Psychology and Psychotherapy, Center of Epidemiology and Longitudinal Studies CELOS, Technische Universitat Dresden, Dresden, Germany
    Eur Neuropsychopharmacol 21:655-79. 2011
  8. ncbi Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire
    R L Spitzer
    Biometrics Research Department, New York State Psychiatric Institute, and Columbia University, New York 10032, USA
    JAMA 282:1737-44. 1999
  9. doi Default-mode brain dysfunction in mental disorders: a systematic review
    Samantha J Broyd
    Institute for Disorders of Impulse and Attention, Developmental Brain Behaviour Laboratory, School of Psychology, University of Southampton, UK
    Neurosci Biobehav Rev 33:279-96. 2009
  10. ncbi No health without mental health
    Martin Prince
    King s College London, Centre for Public Mental Health, Health Service and Population Research Department, Institute of Psychiatry, London, UK
    Lancet 370:859-77. 2007

Detail Information

Publications303 found, 100 shown here

  1. pmc Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidence
    Ilan H Meyer
    Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Psychol Bull 129:674-97. 2003
    In this article the author reviews research evidence on the prevalence of mental disorders in lesbians, gay men, and bisexuals (LGBs) and shows, using meta-analyses, that LGBs have a higher prevalence of mental disorders than ..
  2. ncbi The Vietnamese version of the Self Reporting Questionnaire 20 (SRQ-20) in detecting mental disorders in rural Vietnam: a validation study
    Kim Bao Giang
    Faculty of Public Health, Hanoi Medical University, Vietnam
    Int J Soc Psychiatry 52:175-84. 2006
    There is a need to develop instruments to measure mental disorders in developing countries because mental disorders are increasingly being recognised as a major public health problem...
  3. ncbi Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Saitama, Japan
    RNA Biol 6:248-53. 2009
    Serotonin receptor 2C (HTR2C) is one of the attractive candidate genes for studying pathophysiology of mental disorders. Here we overviewed the genetic, expression and RNA editing studies suggesting the close relationship between HTR2C ..
  4. ncbi Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:593-602. 2005
    ..Little is known about lifetime prevalence or age of onset of DSM-IV disorders...
  5. ncbi Short screening scales to monitor population prevalences and trends in non-specific psychological distress
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Psychol Med 32:959-76. 2002
    ..A 10-question screening scale of psychological distress and a six-question short-form scale embedded within the 10-question scale were developed for the redesigned US National Health Interview Survey (NHIS)...
  6. pmc Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:617-27. 2005
    Little is known about the general population prevalence or severity of DSM-IV mental disorders.
  7. doi The size and burden of mental disorders and other disorders of the brain in Europe 2010
    H U Wittchen
    Institute of Clinical Psychology and Psychotherapy, Center of Epidemiology and Longitudinal Studies CELOS, Technische Universitat Dresden, Dresden, Germany
    Eur Neuropsychopharmacol 21:655-79. 2011
    ....
  8. ncbi Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire
    R L Spitzer
    Biometrics Research Department, New York State Psychiatric Institute, and Columbia University, New York 10032, USA
    JAMA 282:1737-44. 1999
    The Primary Care Evaluation of Mental Disorders (PRIME-MD) was developed as a screening instrument but its administration time has limited its clinical usefulness.
  9. doi Default-mode brain dysfunction in mental disorders: a systematic review
    Samantha J Broyd
    Institute for Disorders of Impulse and Attention, Developmental Brain Behaviour Laboratory, School of Psychology, University of Southampton, UK
    Neurosci Biobehav Rev 33:279-96. 2009
    ..are concerned specifically with the putative role of the default-mode network (DMN) in the pathophysiology of mental disorders. First, we define the DMN concept with regard to its neuro-anatomy, its functional organisation through low ..
  10. ncbi No health without mental health
    Martin Prince
    King s College London, Centre for Public Mental Health, Health Service and Population Research Department, Institute of Psychiatry, London, UK
    Lancet 370:859-77. 2007
    ..to neuropsychiatric disorders, mostly due to the chronically disabling nature of depression and other common mental disorders, alcohol-use and substance-use disorders, and psychoses...
  11. ncbi Screening for serious mental illness in the general population
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Suite 215, Boston, MA 02115, USA
    Arch Gen Psychiatry 60:184-9. 2003
    ..Public Law 102-321 established a block grant for adults with "serious mental illness" (SMI) and required the Substance Abuse and Mental Health Services Administration (SAMHSA) to develop a method to estimate the prevalence of SMI...
  12. ncbi Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys
    Koen Demyttenaere
    JAMA 291:2581-90. 2004
    Little is known about the extent or severity of untreated mental disorders, especially in less-developed countries.
  13. ncbi Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Rd, Suite 1300, Dallas, TX 75390 9119, USA
    Am J Psychiatry 163:28-40. 2006
    ....
  14. ncbi Interpreting scores on the Kessler Psychological Distress Scale (K10)
    G Andrews
    World Health Organization Collaborating Centre in Evidence for Mental Health Policy and School of Psychiatry, University of New South Wales at St Vincent s Hospital, Darlinghurst
    Aust N Z J Public Health 25:494-7. 2001
    ..To provide normative data on the Kessler Psychological Distress Scale (K10), a scale that is being increasingly used for clinical and epidemiological purposes...
  15. ncbi Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care
    Charles W Hoge
    Department of Psychiatry and Behavioral Sciences, Walter Reed Army Institute of Research, U S Army Medical Research and Materiel Command, Silver Spring, MD 20910, USA
    N Engl J Med 351:13-22. 2004
    ....
  16. doi Poverty and mental disorders: breaking the cycle in low-income and middle-income countries
    Crick Lund
    Centre for Public Mental Health, Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    Lancet 378:1502-14. 2011
    ..This study supports the call to scale up mental health care, not only as a public health and human rights priority, but also as a development priority...
  17. ncbi Size and burden of mental disorders in Europe--a critical review and appraisal of 27 studies
    Hans Ulrich Wittchen
    Clinical Psychology and Psychotherapy, Technical University of Dresden, Dresden, Germany
    Eur Neuropsychopharmacol 15:357-76. 2005
    Epidemiological data on a wide range of mental disorders from community studies conducted in European countries are presented to determine the availability and consistency of prevalence, disability and treatment findings for the EU...
  18. ncbi Prevalence, co-morbidity and correlates of mental disorders in the general population: results from the German Health Interview and Examination Survey (GHS)
    F Jacobi
    Institute of Clinical Psychology and Psychotherapy, Unit Epidemiology and Service Research, Technical University of Dresden, Germany
    Psychol Med 34:597-611. 2004
    ..GHS) is the first government mandated nationwide study to investigate jointly the prevalence of somatic and mental disorders within one study in the general adult population in Germany...
  19. ncbi Association between physical activity and mental disorders among adults in the United States
    Renee D Goodwin
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Prev Med 36:698-703. 2003
    The objective of this study was to determine the association between regular physical activity and mental disorders among adults in the United States.
  20. ncbi Resources for mental health: scarcity, inequity, and inefficiency
    Shekhar Saxena
    World Health Organization, Geneva, Switzerland
    Lancet 370:878-89. 2007
    ..health in most of the relevant countries is far lower than is needed, based on the proportionate burden of mental disorders and the availability of cost-effective and affordable interventions...
  21. ncbi The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI)
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Int J Methods Psychiatr Res 13:93-121. 2004
    ..Elaborate CD-ROM-based training materials are available to teach interviewers how to administer the interview as well as to teach supervisors how to monitor the quality of data collection...
  22. ncbi Smoking and mental illness: A population-based prevalence study
    K Lasser
    Department of Medicine, Cambridge Hospital, Macht Bldg, 1493 Cambridge St, Cambridge, MA 02139, USA
    JAMA 284:2606-10. 2000
    ..However, recent population-based, nationally representative data are lacking...
  23. ncbi Treatment and prevention of mental disorders in low-income and middle-income countries
    Vikram Patel
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 370:991-1005. 2007
    We review the evidence on effectiveness of interventions for the treatment and prevention of selected mental disorders in low-income and middle-income countries...
  24. ncbi The Composite International Diagnostic Interview. An epidemiologic Instrument suitable for use in conjunction with different diagnostic systems and in different cultures
    L N Robins
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110
    Arch Gen Psychiatry 45:1069-77. 1988
    ..If all goes well, the CIDI will allow investigators reliably to assess mental disorders according to the most widely accepted nomenclatures in many different populations and cultures.
  25. ncbi The DISC locus in psychiatric illness
    J E Chubb
    Medical Genetics Section, The Centre for Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 13:36-64. 2008
    ..DISC1 is a hub protein in a multidimensional risk pathway for major mental illness, and studies of this pathway are opening up opportunities for a better understanding of causality and possible mechanisms of intervention...
  26. doi Common mental disorders among HIV-infected individuals in South Africa: prevalence, predictors, and validation of brief psychiatric rating scales
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    AIDS Patient Care STDS 22:147-58. 2008
    Despite the high prevalence of both mental disorders and HIV infection in much of sub-Saharan Africa, little is known about the occurrence of mental health disorders among HIV-infected individuals...
  27. pmc Prevalence and treatment of mental disorders, 1990 to 2003
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 352:2515-23. 2005
    Although the 1990s saw enormous change in the mental health care system in the United States, little is known about changes in the prevalence or rate of treatment of mental disorders.
  28. pmc Prognostic factors of long term disability due to mental disorders: a systematic review
    L R Cornelius
    Department of Health Sciences, Section of Social Medicine, Work and Health, University Medical Center Groningen, Antonius Deusinglaan, The Netherlands
    J Occup Rehabil 21:259-74. 2011
    ..Recommendations are made as to directions and methodological quality of further research, i.e., prognostic cohort studies...
  29. pmc Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication--Adolescent Supplement (NCS-A)
    Kathleen Ries Merikangas
    Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 49:980-9. 2010
    To present estimates of the lifetime prevalence of DSM-IV mental disorders with and without severe impairment, their comorbidity across broad classes of disorder, and their sociodemographic correlates.
  30. pmc Trends and risk factors for mental health diagnoses among Iraq and Afghanistan veterans using Department of Veterans Affairs health care, 2002-2008
    Karen H Seal
    San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Am J Public Health 99:1651-8. 2009
    ..We sought to investigate longitudinal trends and risk factors for mental health diagnoses among Iraq and Afghanistan veterans...
  31. ncbi The diagnosis of mental disorders: the problem of reification
    Steven E Hyman
    Department of Neurobiology, Harvard Medical School, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Clin Psychol 6:155-79. 2010
    A pressing need for interrater reliability in the diagnosis of mental disorders emerged during the mid-twentieth century, prompted in part by the development of diverse new treatments...
  32. ncbi Twelve-month use of mental health services in the United States: results from the National Comorbidity Survey Replication
    Philip S Wang
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Arch Gen Psychiatry 62:629-40. 2005
    ..Dramatic changes have occurred in mental health treatments during the past decade. Data on recent treatment patterns are needed to estimate the unmet need for services...
  33. ncbi Scale up services for mental disorders: a call for action
    D Chisholm
    Lancet 370:1241-52. 2007
    ..stakeholders, such as professional bodies and consumer groups, to scale up the coverage of services for mental disorders in all countries, but especially in low-income and middle-income countries...
  34. ncbi The epidemiology of excess mortality in people with mental illness
    David Lawrence
    Centre for Developmental Health, Curtin University of Technology and Telethon Institute for Child Health Research, Perth, Australia
    Can J Psychiatry 55:752-60. 2010
    ..to investigate the burden of excess mortality among people with mental illness in developed countries, how it is distributed, and whether it has changed over time...
  35. pmc Common perinatal mental disorders in northern Viet Nam: community prevalence and health care use
    Jane Fisher
    Centre for Women s Health, Gender and Society, University of Melbourne, Carlton, Vic, 3010, Australia
    Bull World Health Organ 88:737-45. 2010
    To establish the prevalence of common perinatal mental disorders their determinants, and their association with preventive health care use among women in one rural and one urban province in northern Viet Nam.
  36. pmc Association between obesity and psychiatric disorders in the US adult population
    Gregory E Simon
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Arch Gen Psychiatry 63:824-30. 2006
    ..Epidemiologic data suggest an association between obesity and depression, but findings vary across studies and suggest a stronger relationship in women than men...
  37. pmc Cross-national prevalence and risk factors for suicidal ideation, plans and attempts
    Matthew K Nock
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Br J Psychiatry 192:98-105. 2008
    ..Suicide is a leading cause of death worldwide; however, the prevalence and risk factors for the immediate precursors to suicide - suicidal ideation, plans and attempts - are not wellknown, especially in low- and middle-income countries...
  38. ncbi Toward a clinical model of suicidal behavior in psychiatric patients
    J J Mann
    Mental Health Clinical Research Center for the Study of Suicidal Behavior, Department of Neuroscience, New York State Psychiatric Institute, New York 10032, USA
    Am J Psychiatry 156:181-9. 1999
    ....
  39. ncbi Distinguishing between the validity and utility of psychiatric diagnoses
    Robert Kendell
    Department of Psychiatry and Behavioural Science, University of Western Australia, Perth, Australia
    Am J Psychiatry 160:4-12. 2003
    ..The meaning of the terms "validity" and "utility" as they apply to psychiatric diagnoses is examined...
  40. pmc Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys
    Philip S Wang
    Division of Services and Intervention Research, National Institute of Mental Health, Rockville, MD, USA
    Lancet 370:841-50. 2007
    b>Mental disorders are major causes of disability worldwide, including in the low-income and middle-income countries least able to bear such burdens...
  41. pmc Psychiatric comorbidity in patients with chronic daily headache and migraine: a selective overview including personality traits and suicide risk
    Maurizio Pompili
    Department of Psychiatry, Sant Andrea Hospital, Sapienza University of Rome, 1035 Via di Grottarossa, Rome 00189, Italy
    J Headache Pain 10:283-90. 2009
    ..The increase in self-efficacy and mental health associated with pharmaceutical care may be instrumental in improving the long-term pharmacotherapy of patients with migraine and headache...
  42. pmc Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health Surveys
    Soraya Seedat
    Medical Research Council Research Unit on Anxiety and Stress Disorder, Cape Town, South Africa
    Arch Gen Psychiatry 66:785-95. 2009
    Gender differences in mental disorders, including more anxiety and mood disorders among women and more externalizing disorders among men, are found consistently in epidemiological surveys...
  43. pmc The burden of mental disorders
    William W Eaton
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Epidemiol Rev 30:1-14. 2008
    ..interest in the burden of chronic and disabling health conditions that are not necessarily fatal, such as the mental disorders. This review systematically summarizes data on the burden associated with 11 major mental disorders of adults...
  44. ncbi Experience sampling research in psychopathology: opening the black box of daily life
    I Myin-Germeys
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Psychol Med 39:1533-47. 2009
    ....
  45. ncbi The mental wealth of nations
    John Beddington
    Government Office for Science, London
    Nature 455:1057-60. 2008
    ..Countries must learn how to capitalize on their citizens' cognitive resources if they are to prosper, both economically and socially. Early interventions will be key...
  46. ncbi Copy-number variations associated with neuropsychiatric conditions
    Edwin H Cook
    Institute for Juvenile Research, Department of Psychiatry, University of Illinois, 1747 West Roosevelt Road, Chicago, Illinois 60608, USA
    Nature 455:919-23. 2008
    ..The complexity of neuropsychiatric genetics, however, dictates that assessment of the biomedical relevance of copy-number variants and the genes that they affect needs to be considered in an integrated context...
  47. pmc The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveys
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Epidemiol Psichiatr Soc 18:23-33. 2009
    The paper reviews recent findings from the WHO World Mental Health (WMH) surveys on the global burden of mental disorders.
  48. ncbi Costs of nine common mental disorders: implications for curative and preventive psychiatry
    Filip Smit
    Trimbos Institute Netherlands Institute of Mental Health and Addiction, P O Box 725, 2500 AS Utrecht, The Netherlands
    J Ment Health Policy Econ 9:193-200. 2006
    b>Mental disorders are highly prevalent and are associated with substantial disease burden, but their economic costs have been relatively less well researched...
  49. ncbi Detecting common mental disorders in primary care in India: a comparison of five screening questionnaires
    V Patel
    London School of Hygiene and Tropical Medicine, London, UK
    Psychol Med 38:221-8. 2008
    Screening of patients for common mental disorders (CMDs) is needed in primary-care management programmes. This study aimed to compare the screening properties of five widely used questionnaires.
  50. doi Poverty and common mental disorders in low and middle income countries: A systematic review
    Crick Lund
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Soc Sci Med 71:517-28. 2010
    ..of high levels of poverty in low and middle income countries (LMIC), and the high burden posed by common mental disorders (CMD), it is only in the last two decades that research has emerged that empirically addresses the ..
  51. doi Prevalence, treatment, and associated disability of mental disorders in four provinces in China during 2001-05: an epidemiological survey
    Michael R Phillips
    WHO Collaborating Centre for Research and Training in Suicide Prevention, Beijing Hui Long Guan Hospital, Beijing, China
    Lancet 373:2041-53. 2009
    ..country-specific data for the prevalence, treatment, and associated disability of different types of mental disorders. We therefore estimated these variables from a series of epidemiological studies that were done in four ..
  52. pmc Individual and societal effects of mental disorders on earnings in the United States: results from the national comorbidity survey replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 165:703-11. 2008
    The purpose of this report was to update previous estimates of the association between mental disorders and earnings. Current estimates for 2002 are based on data from the National Comorbidity Survey Replication (NCS-R).
  53. pmc Common mental disorders in TB/HIV co-infected patients in Ethiopia
    Amare Deribew
    Department of Epidemiology, Jimma University, Jimma, Ethiopia
    BMC Infect Dis 10:201. 2010
    The relationship between TB/HIV co-infection and common mental disorders (CMD) has been scarcely investigated. In this study, we compared the occurrence of CMD in TB/HIV co-infected and non-co-infected HIV patients in Ethiopia.
  54. ncbi Russian child mental health--a cross-sectional study of prevalence and risk factors
    Robert Goodman
    Dept of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Eur Child Adolesc Psychiatry 14:28-33. 2005
    ..The fall of communism and subsequent economic crises have been followed by major social and health problems. High rates of child mental health problems are frequently cited by the Russian media, though there is little relevant evidence...
  55. ncbi A brief case-finding questionnaire for common mental disorders: the CMDQ
    Kaj Sparle Christensen
    The Research Unit for General Practice, University of Aarhus, Denmark
    Fam Pract 22:448-57. 2005
    The aim of the study was to validate a new case-finding instrument for common mental disorders (CMDQ).
  56. pmc Neuroeconomic approaches to mental disorders
    Kenneth T Kishida
    Department of Neuroscience and Computational Psychiatry Unit, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 67:543-54. 2010
    ..This review surveys the recent and productive application of game-theoretic probes (economic games) to mental disorders. Such games typically possess concrete concepts of optimal play, thus providing quantitative ways to track ..
  57. doi Obesity among those with mental disorders: a National Institute of Mental Health meeting report
    David B Allison
    University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Prev Med 36:341-50. 2009
    ..in October 2005 to review the literature on obesity, nutrition, and physical activity among those with mental disorders. The findings of this meeting and subsequent update of the literature review are summarized here...
  58. ncbi Generalizability studies of the Global Assessment of Functioning-Split version
    Geir Pedersen
    Department of Personality Psychiatry, Ulleval University Hospital, 0407 Oslo, Norway
    Compr Psychiatry 48:88-94. 2007
    ..The study aimed to use the Generalizability Theory to investigate the reliability and precision of the split version of the Global Assessment of Functioning (GAF)...
  59. ncbi Risk for psychopathology in the children of depressed mothers: a developmental model for understanding mechanisms of transmission
    S H Goodman
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    Psychol Rev 106:458-90. 1999
    ..Relevant issues are discussed, and promising directions for future research are suggested...
  60. doi Lifetime prevalence of gender-based violence in women and the relationship with mental disorders and psychosocial function
    Susan Rees
    School of Psychiatry, University of New South Wales, and Center for Population Mental Health Research, Liverpool Hospital, Sydney South West Area Health Network, Sydney, New South Wales, Australia 2170
    JAMA 306:513-21. 2011
    ..An association between these forms of abuse and lifetime mental disorder and psychosocial disability among women needs to be examined...
  61. ncbi Mental health of young people: a global public-health challenge
    Vikram Patel
    Department of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 369:1302-13. 2007
    b>Mental disorders account for a large proportion of the disease burden in young people in all societies. Most mental disorders begin during youth (12-24 years of age), although they are often first detected later in life...
  62. ncbi Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 60:804-15. 2003
    ....
  63. ncbi Population level of unmet need for mental healthcare in Europe
    Jordi Alonso
    Health Services Research Unit, Institut Municipal d Investigacio Medica, Carrer del Doctor Aiguader, 88 E 08003 Barcelona, Spain
    Br J Psychiatry 190:299-306. 2007
    The high prevalence of mental disorders has fuelled controversy about the need for mental health services.
  64. ncbi NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses
    D Shaffer
    Division of Child and Adolescent Psychiatry, Columbia University, New York 10032, USA
    J Am Acad Child Adolesc Psychiatry 39:28-38. 2000
    ..The interview is available in both English and Spanish versions...
  65. ncbi Concordance of the Composite International Diagnostic Interview Version 3.0 (CIDI 3.0) with standardized clinical assessments in the WHO World Mental Health surveys
    Josep Maria Haro
    Int J Methods Psychiatr Res 15:167-80. 2006
    ..The validity of the CIDI is likely to be under-estimated in these comparisons due to the fact that the reliability of the SCID diagnoses, which is presumably less than perfect, sets a ceiling on maximum CIDI-SCID concordance...
  66. pmc Prolonged grief disorder: Psychometric validation of criteria proposed for DSM-V and ICD-11
    Holly G Prigerson
    Department of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Med 6:e1000121. 2009
    ....
  67. pmc Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis
    Karestan C Koenen
    Department of Society, Human Development, and Health, Harvard School of Public Health, Kresge 613, 677 Huntington Ave, Boston, MA 02115, USA
    Am J Psychiatry 166:50-7. 2009
    ..However, tests of the association between premorbid IQ and adult mental disorders other than schizophrenia have been limited and inconclusive...
  68. ncbi The British Child and Adolescent Mental Health Survey 1999: the prevalence of DSM-IV disorders
    Tamsin Ford
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Denmark Hill, London SE58AF, England
    J Am Acad Child Adolesc Psychiatry 42:1203-11. 2003
    ..To describe the prevalence of DSM-IV disorders and comorbidity in a large population-based sample of British children and adolescents...
  69. doi An examination of premature mortality among decedents with serious mental illness and those in the general population
    ELIZABETH E PIATT
    Department of Behavioral and Community Health Sciences, NortheasternOhio Universities Colleges of Medicine and Pharmacy, 4209 State Route 44, Rootstown, OH 44272, USA
    Psychiatr Serv 61:663-8. 2010
    ....
  70. pmc The treatment gap in mental health care
    Robert Kohn
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    Bull World Health Organ 82:858-66. 2004
    b>Mental disorders are highly prevalent and cause considerable suffering and disease burden. To compound this public health problem, many individuals with psychiatric disorders remain untreated although effective treatments exist...
  71. pmc Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders
    Jennifer Greif Green
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Arch Gen Psychiatry 67:113-23. 2010
    Although significant associations of childhood adversities (CAs) with adult mental disorders have been documented consistently in epidemiological surveys, these studies generally have examined only 1 CA per study...
  72. ncbi Serious mental illness and physical health problems: a discussion paper
    Debbie Robson
    Health Services Research Department, King s College London, Section of Psychiatric Nursing, Institute of Psychiatry, De Crespigny Park, London, UK
    Int J Nurs Stud 44:457-66. 2007
    ..There are opportunities for mental health nurses to play a significant role in improving both the physical and mental health of people with serious mental illness...
  73. ncbi Self-harm
    Keren Skegg
    Department of Psychological Medicine, University of Otago Medical School, PO Box 913 Dunedin, New Zealand
    Lancet 366:1471-83. 2005
    ..Although risk factors for self-harm are well established, aspects that protect people from engaging in self-harm need to be further explored...
  74. pmc Development of lifetime comorbidity in the World Health Organization world mental health surveys
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Arch Gen Psychiatry 68:90-100. 2011
    Although numerous studies have examined the role of latent variables in the structure of comorbidity among mental disorders, none has examined their role in the development of comorbidity.
  75. ncbi The endophenotype concept in psychiatry: etymology and strategic intentions
    Irving I Gottesman
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55454, USA
    Am J Psychiatry 160:636-45. 2003
    ..The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics...
  76. pmc The role of circadian clock genes in mental disorders
    Elaine Waddington Lamont
    Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute, Montreal, QC, Canada
    Dialogues Clin Neurosci 9:333-42. 2007
    ..Sleep and circadian changes associated with dementia due to Alzheimer's disease suggest a functional change in the circadian master clock, which is supported by postmortem studies of clock gene expression in the brain...
  77. pmc All-cause mortality among people with serious mental illness (SMI), substance use disorders, and depressive disorders in southeast London: a cohort study
    Chin Kuo Chang
    King s College London, Section of Epidemiology, Dept of Health Service and Population Research, Institute of Psychiatry, London, UK
    BMC Psychiatry 10:77. 2010
    ..Our aim was to characterize vulnerable groups for excess mortality among people with SMI, substance use disorders, depressive episode, and recurrent depressive disorder...
  78. ncbi Smoking cessation in severe mental illness: what works?
    Lindsay Banham
    South London and the Maudsley Mental Health Trust, Beckenham, Kent, UK
    Addiction 105:1176-89. 2010
    ..Smoking-related illnesses are a major contributor to excess mortality and morbidity. An up-to-date review of the evidence for smoking cessation interventions in SMI is needed to inform clinical guidelines...
  79. ncbi Prevalence and severity of mental health-related disability and relationship to diagnosis
    Kristy Sanderson
    University of New South Wales, St Vincent s Hospital, Darlinghurst, Australia
    Psychiatr Serv 53:80-6. 2002
    ..This practice may have led to substantial underestimation of the total impact of mental disorders on community health...
  80. ncbi Clinical factors influencing the prescription of antidepressants and benzodiazepines: results from the European study of the epidemiology of mental disorders (ESEMeD)
    Koen Demyttenaere
    Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
    J Affect Disord 110:84-93. 2008
    ..To examine factors associated with the use of antidepressants (AD) and benzodiazepines (BZD) in 6 European countries...
  81. ncbi Management of smoking cessation in patients with psychiatric disorders
    Karl Fagerström
    Smokers Information Centre, Fagerstrom Consulting AB, Helsingborg, Sweden
    Curr Med Res Opin 25:511-8. 2009
    ....
  82. ncbi School absenteeism and school refusal behavior in youth: a contemporary review
    Christopher A Kearney
    Department of Psychology, University of Nevada, Las Vegas, Las Vegas, NV 89154 5030, USA
    Clin Psychol Rev 28:451-71. 2008
    ....
  83. pmc Cost-effectiveness of a workplace intervention for sick-listed employees with common mental disorders: design of a randomized controlled trial
    Sandra H van Oostrom
    Department of Public and Occupational Health, VU University Medical Center, Amsterdam, The Netherlands
    BMC Public Health 8:12. 2008
    ..of sick leave and the consequences of sick leave for employees, an early return-to-work of employees with mental disorders is very important...
  84. doi Failure to improve appropriateness of referrals to adult community mental health services--lessons from a multi-site cluster randomized controlled trial
    Mike Slade
    Health Service and Population Research Department HSPRD, Institute of Psychiatry, King s College London, Denmark Hill, London SE5 8AF, UK
    Fam Pract 25:181-90. 2008
    ..The aim of this study was to investigate whether introducing a standardized assessment of severity improves agreement on referrals...
  85. ncbi A case for establishing complicated grief as a distinct mental disorder in DSM-V
    Wendy G Lichtenthal
    Department of Psychology, 3720 Walnut Street, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Psychol Rev 24:637-62. 2004
    ..This paper concludes that CG must be established in the current nosology to address the needs of individuals who are significantly suffering and impaired by this disorder...
  86. doi Epigenetic profiling in schizophrenia and major mental disorders
    Kazuya Iwamoto
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan
    Neuropsychobiology 60:5-11. 2009
    ..such as DNA methylation and histone modifications are important in the etiology or pathophysiology of mental disorders. Here, we review recent studies on the relationship between DNA methylation and major mental disorders...
  87. ncbi A Norwegian psychiatric epidemiological study
    E Kringlen
    Department of Psychiatry, University of Oslo, Norway
    Am J Psychiatry 158:1091-8. 2001
    ..The mean age of the interviewed subjects was 39.3 years. RESULTS: The 12-month prevalence of all mental disorders was 32.8%, and the lifetime prevalence was 52.4%...
  88. ncbi Prevalence and development of psychiatric disorders in childhood and adolescence
    E Jane Costello
    Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC 27710, USA
    Arch Gen Psychiatry 60:837-44. 2003
    ..This longitudinal community study assessed the prevalence and development of psychiatric disorders from age 9 through 16 years and examined homotypic and heterotypic continuity...
  89. ncbi Bullying at school--an indicator of adolescents at risk for mental disorders
    R Kaltiala-Heino
    University of Tampere, Tampere School of Public Health, Tampere, Finland
    J Adolesc 23:661-74. 2000
    ..Among girls, eating disorders were associated with involvement in bullying in any role, among boys with being bully-victims. Bullying should be seen as an indicator of risk of various mental disorders in adolescence.
  90. pmc Mental disorders, comorbidity and suicidal behavior: results from the National Comorbidity Survey Replication
    M K Nock
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Mol Psychiatry 15:868-76. 2010
    b>Mental disorders are among the strongest predictors of suicide attempts. However, little is known regarding which disorders that are uniquely associated with suicidal behavior because of high levels of psychiatric comorbidity...
  91. pmc The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes
    William Hennah
    Medical Genetics Section, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 4:e4906. 2009
    ..There is evidence for genetic interplay between variants in DISC1 and in biologically interacting loci in psychiatric illness. DISC1 also associates with normal variance in behavioral and brain imaging phenotypes...
  92. ncbi Comorbid mental disorders account for the role impairment of commonly occurring chronic physical disorders: results from the National Comorbidity Survey
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Occup Environ Med 45:1257-66. 2003
    ..We illustrate the implication of this neglect by examining the effects of comorbid mental disorders on role impairment (number of sickness absence and work cut-back days in the past month) among people with ..
  93. pmc How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment
    T E Moffitt
    Duke University, Durham, NC 27708, USA
    Psychol Med 40:899-909. 2010
    Most information about the lifetime prevalence of mental disorders comes from retrospective surveys, but how much these surveys have undercounted due to recall failure is unknown...
  94. ncbi Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy
    A Rozanski
    Division of Cardiology, Department of Medicine, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Circulation 99:2192-217. 1999
    ..When they do so, the resultant risk for cardiac events is often substantially elevated, equaling that associated with previously established risk factors for CAD, such as hypertension and hypercholesterolemia...
  95. ncbi Representativeness of clinical samples of youths with mental disorders: a preliminary population-based study
    S H Goodman
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    J Abnorm Psychol 106:3-14. 1997
    In a household community sample of 1,285, 9-17 years-olds with mental disorders who had received outpatient specialty mental health services in the past year were compared with youths with mental disorders who had not received those ..
  96. ncbi Validity issues in transcultural epidemiology
    Mark van Ommeren
    Br J Psychiatry 182:376-8. 2003
  97. ncbi Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits
    Richard Levy
    Fédération de Neurologie and INSERM U610, Hopital de la Salpetriere, Paris, France
    Cereb Cortex 16:916-28. 2006
    ..In both situations (direct basal ganglia lesions and nigro-striatal dopaminergic loss), the capacity of the frontal cortex to select, initiate, maintain and shift programs of actions is impaired...
  98. ncbi Common mental disorders in Santiago, Chile: prevalence and socio-demographic correlates
    R Araya
    Psychological Medicine, University of Wales College of Medicine, Cardiff
    Br J Psychiatry 178:228-33. 2001
    ..There have been relatively few surveys in Latin America that have attempted to estimate the prevalence of psychiatric morbidity in private households...
  99. ncbi The health of UK military personnel who deployed to the 2003 Iraq war: a cohort study
    Matthew Hotopf
    King s Centre for Military Health Research, King s College London, London, UK
    Lancet 367:1731-41. 2006
    ..Concerns have been raised about the mental and physical health of UK military personnel who deployed to the 2003 war in Iraq and subsequent tours of duty in the country...
  100. pmc Research applications of magnetic resonance spectroscopy to investigate psychiatric disorders
    Stephen R Dager
    Department of Radiology, Neuroimaging Research Group, University of Washington School of Medicine, 1100 NE 45th Street, Seattle, WA 98105, USA
    Top Magn Reson Imaging 19:81-96. 2008
    ....
  101. ncbi Social inequalities and the common mental disorders: a systematic review of the evidence
    Tom Fryers
    Department of Psychiatry, University of Leicester, Leicester, UK
    Soc Psychiatry Psychiatr Epidemiol 38:229-37. 2003
    Of two large-scale government-commissioned studies of common mental disorders in the UK, one found occupational social class to be the strongest marker of risk while the other showed no clear relationship...

Research Grants99

  1. Empirical eating disorder classification and validation using prospective studies
    Nadia Micali; Fiscal Year: 2010
    ..1-1% have anorexia nervosa and 1-3% have bulimia nervosa. Although the Diagnostic and Statistical Manual for Mental Disorders-IV (DSM-IV) criteria are widely used to classify individuals, the eating disorder diagnoses were not ..
  2. Emotions are emergent events constrained by affective and conceptual processes.
    Lisa Barrett; Fiscal Year: 2009
    ..abstract_text> ..
  3. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..RFA-OD-09-003) 03- MH-101, Biomarkers in mental disorders. The goal of the proposal is to develop biomarkers for the detection of amyloid plaques in living humans...
  4. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2009
    ..RFA-OD-09-003) 03- MH-101, Biomarkers in mental disorders. The goal of the proposal is to develop biomarkers for the detection of amyloid plaques in living humans...
  5. Safety signal learning in Rhesus monkeys following early life stressChallenge Ar
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic 03-MH-101* Biomarkers in mental disorders. The major hypothesis is that post-traumatic stress disorder (PTSD) leads to a reduction in the ability to ..
  6. Safety signal learning in Rhesus monkeys following early life stressChallenge Ar
    Michael Davis; Fiscal Year: 2009
    ..Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic 03-MH-101* Biomarkers in mental disorders. The major hypothesis is that post-traumatic stress disorder (PTSD) leads to a reduction in the ability to ..
  7. Validation of a functional MRI-based reward processing task as a non-invasive too
    Mary Phillips; Fiscal Year: 2009
    ..Area (03) Biomarker Discovery and Validation and specific Challenge topic, 03-MH-101*: Biomarkers in mental disorders. Psychiatric Disorders such as alcohol and other substance abuse disorders, unipolar depression, bipolar ..
  8. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..Area (03) Biomarker Discovery and Validation and specific Challenge topic, 03-MH-101*: Biomarkers in mental disorders. Psychiatric Disorders such as alcohol and other substance abuse disorders, unipolar depression, bipolar ..
  9. Mechanisms Underlying Social Cooperative Behavior
    Luke Chang; Fiscal Year: 2009
    ..mission to advance the integration of behavior and brain science to provide a greater understanding of mental disorders, this proposal combines theories and methods from the diverse fields of psychology, economics, and ..
  10. Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa
    Nancy Zucker; Fiscal Year: 2009
    ..by applicant): (03) Biomarker Discovery and Validation general challenge Area and the 03-MH-101 Biomarkers in mental disorders specific challenge topic. Anorexia nervosa (AN) is a terrifying and perplexing disorder...
  11. Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa
    NANCY L contact ZUCKER; Fiscal Year: 2010
    ..by applicant): (03) Biomarker Discovery and Validation general challenge Area and the 03-MH-101 Biomarkers in mental disorders specific challenge topic. Anorexia nervosa (AN) is a terrifying and perplexing disorder...
  12. Empirical eating disorder classification and validation using prospective studies
    ALISON E contact FIELD; Fiscal Year: 2011
    ..1-1% have anorexia nervosa and 1-3% have bulimia nervosa. Although the Diagnostic and Statistical Manual for Mental Disorders-IV (DSM-IV) criteria are widely used to classify individuals, the eating disorder diagnoses were not ..
  13. Functional and Structural Neuroanatomy in Late-Life Generalized Anxiety Disorder
    Carmen Andreescu; Fiscal Year: 2010
    ..prevalent anxiety disorder in the elderly, but it remains one of the most underdiagnosed and less studied mental disorders. It is well known that the aging brain experiences neuroanatomical change, and it has been observed that the ..
  14. Adolescent Alcohol,Dysregulated Stress System, and PTSD Vulnerability
    GERHARD SCHULTEIS; Fiscal Year: 2009
    ..S. population, a recent study reported that PTSD represents nearly half of all mental disorders for veterans of Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF)...
  15. Medicare Part D Cost-Sharing and Treatment of Mental Disorders Among Disabled Dua
    Julie Donohue; Fiscal Year: 2009
    ..Medicare Part D cost-sharing policy on treatment patterns and costs for dually eligible beneficiaries with mental disorders. The objectives of this study are to examine the impact of the increased co-payments on (1) prescription drug ..
  16. Medicare Part D Cost-Sharing and Treatment of Mental Disorders Among Disabled Dua
    Julie Marie Donohue; Fiscal Year: 2010
    ..Medicare Part D cost-sharing policy on treatment patterns and costs for dually eligible beneficiaries with mental disorders. The objectives of this study are to examine the impact of the increased co-payments on (1) prescription drug ..
  17. GENE EXPRESSION EXON ARRAY BIOMARKERS TO DIAGNOSE SCHIZOPHRENIA
    Terry W Osborn; Fiscal Year: 2010
    ..effort may alter medical treatment by providing more effective drugs, appropriate early interventions for mental disorders. The specific objective of this pilot study is to demonstrate predictive and, consistent surrogate biomarkers ..
  18. Derivation of cerebral cortical GABAergic interneurons from human iPS cells
    Stewart Anderson; Fiscal Year: 2009
    ..Specific challenge topic 14-MH-101: Developing iPS cells for mental disorders. Dysfunction of GABAergic interneurons of the cerebral cortex has been implicated in a variety of major ..
  19. Derivation of cerebral cortical GABAergic interneurons from human iPS cells
    Lorenz P Studer; Fiscal Year: 2010
    ..Specific challenge topic 14-MH-101: Developing iPS cells for mental disorders. Dysfunction of GABAergic interneurons of the cerebral cortex has been implicated in a variety of major ..
  20. Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Con
    Hilary Blumberg; Fiscal Year: 2009
    ..Challenge Area (03) Biomarker Discovery and Validation and specific Challenge topic, 03-MH-101: Biomarkers in Mental Disorders and is entitled: Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Contribute to High ..
  21. Using fMRI to Measure Negative Symptoms in Schizophrenia
    EDWARD E contact SMITH; Fiscal Year: 2010
    ..Area 03: Biomarker Discrimination and Validation, and the specific challenge topic: 03-MG-101, Biomarkers of mental disorders. Schizophrenia, a devastating psychiatric disorder, is chiefly characterized by positive symptoms, such as ..
  22. Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Con
    Hilary P Blumberg; Fiscal Year: 2010
    ..Challenge Area (03) Biomarker Discovery and Validation and specific Challenge topic, 03-MH-101: Biomarkers in Mental Disorders and is entitled: Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Contribute to High ..
  23. Using fMRI to Measure Negative Symptoms in Schizophrenia
    Edward Smith; Fiscal Year: 2009
    ..Area 03: Biomarker Discrimination and Validation, and the specific challenge topic: 03-MG-101, Biomarkers of mental disorders. Schizophrenia, a devastating psychiatric disorder, is chiefly characterized by positive symptoms, such as ..
  24. Does depression affect quality of decisions to participate in clinical trials?
    Yan Leykin; Fiscal Year: 2010
    ..provided by applicant): Major depressive disorder (MDD) is one of the most prevalent and debilitating mental disorders in the world...
  25. Developing Novel Dual CRF-R1/Orexin-1 Receptor Antagonists for Tobacco Dependence
    Belew Mekonnen; Fiscal Year: 2011
    ..has been implicated in complex major health disorders such as cancer, stroke, cardiovascular diseases, and mental disorders. In the USA alone, 30% of all cancer deaths and 87% of all lung cancer deaths are reported to be tobacco-use ..
  26. Anxiety development in 5-HT1A autoreceptor knockout mice, interaction with stress
    Sheryl Beck; Fiscal Year: 2009
    ..Area (15) Translational Science, Gene x environment x development (GxExD) studies of brain function and mental disorders. Gene x environment epidemiology and psychiatry research studies have only recently been used and the ..
  27. Anxiety development in 5-HT1A autoreceptor knockout mice, interaction with stress
    Rene Hen; Fiscal Year: 2010
    ..Area (15) Translational Science, Gene x environment x development (GxExD) studies of brain function and mental disorders. Gene x environment epidemiology and psychiatry research studies have only recently been used and the ..
  28. Effect of D-cycloserine on treatment of PTSD in youth
    Michael S Scheeringa; Fiscal Year: 2010
    ..and Specific Challenge Topic "04-MH-103: Interventions That Target Symptom Dimensions of Childhood-Onset Mental Disorders." The family of cognitive-behavioral therapies (CBT) is a recommended intervention for posttraumatic stress ..
  29. Effect of D-cycloserine on treatment of PTSD in youth
    Michael Scheeringa; Fiscal Year: 2009
    ..and Specific Challenge Topic "04-MH-103: Interventions That Target Symptom Dimensions of Childhood-Onset Mental Disorders." The family of cognitive-behavioral therapies (CBT) is a recommended intervention for posttraumatic stress ..
  30. Social Cognition and Functioning in Bipolar Disorder
    Michael Green; Fiscal Year: 2009
    ..challenge area "03: Biomarker discovery and validation" with the specific topic "03-MH-101: Biomarkers in mental disorders." It will lead to the hiring or retention of three fulltime staff members...
  31. Social Cognition and Functioning in Bipolar Disorder
    Michael F Green; Fiscal Year: 2010
    ..challenge area "03: Biomarker discovery and validation" with the specific topic "03-MH-101: Biomarkers in mental disorders." It will lead to the hiring or retention of three fulltime staff members...
  32. Hurricane Katrina Community Advisory Group
    Ronald C Kessler; Fiscal Year: 2010
    ..the enormous devastation and slow pace of reconstruction after Katrina are likely to lead to delayed-onset mental disorders and slower recovery than in more typical disasters, making it important for needs assessment tracking to be ..
  33. Hurricane Katrina Community Advisory Group
    Ronald Kessler; Fiscal Year: 2009
    ..the enormous devastation and slow pace of reconstruction after Katrina are likely to lead to delayed-onset mental disorders and slower recovery than in more typical disasters, making it important for needs assessment tracking to be ..
  34. Genetics, family environment, and neighborhood: impact on mental disorders
    JAN O SUNDQUIST; Fiscal Year: 2010
    ..This in turn will aid health professionals in the diagnosis, treatment, and counseling of those with psychiatric and substance use disorders, and decision-makers and others in developing more effective public policies. ..
  35. CONTINUITY OF LIMBIC CIRCUIT THROUGH THE BASAL GANGLIA
    Suzanne Haber; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Mental disorders, including, obsessive-compulsive disorder (OCD), schizophrenia, and drug addiction are linked to pathology in the cortico-basal ganglia (BG), reward circuit...
  36. Psychobiology of Trauma and Resilience Across Lifespan
    Dean Kilpatrick; Fiscal Year: 2006
    ..crime, disasters, terrorism, and war is high, and exposure is demonstrated to increase risk of several mental disorders including depression, PTSD, and substance use disorders...
  37. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 2001
    ..Abnormal levels of MAO activity have been associated with a number of mental disorders. A better understanding of these isoenzymes will allow for the development of more effective treatments for ..
  38. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 2007
    ..Abnormal levels of MAO activity have[unreadable] been associated with a number of mental disorders. A better understanding[unreadable] of these isoenzymes will allow for the development of more effective[..
  39. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 1999
    ..Abnormal levels of MAO activity have been associated with a number of mental disorders. A better understanding of these isoenzymes will allow for the development of more effective treatments for ..
  40. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 2002
    ..Abnormal levels of MAO activity have been associated with a number of mental disorders. A better understanding of these isoenzymes will allow for the development of more effective treatments for ..
  41. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 2000
    ..Abnormal levels of MAO activity have been associated with a number of mental disorders. A better understanding of these isoenzymes will allow for the development of more effective treatments for ..
  42. Development of Amygdala specific monoclonal Antibodies
    Andreas Kottmann; Fiscal Year: 2002
    ..structures, which consolidate and express emotions and has been implicated in the pathogenesis of affective mental disorders including depression...
  43. Genetic markers of white matter integrity in schizophrenia: Relationship to clini
    Vince Calhoun; Fiscal Year: 2009
    ..Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic 03-MH-101* Biomarkers in Mental Disorders. Specifically, we plan to use a combination of genetic and neuroimaging tools to identify novel biomarkers of ..
  44. Nuclear Receptor Networks in Human Disease
    Frances M Sladek; Fiscal Year: 2010
    ..Furthermore, several nuclear receptors are very effective drug targets, for both metabolic and mental disorders, making them among the most clinically relevant of all the transcription factors...
  45. Genetic markers of white matter integrity in schizophrenia: Relationship to clini
    Vince D Calhoun; Fiscal Year: 2010
    ..Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic 03-MH-101* Biomarkers in Mental Disorders. Specifically, we plan to use a combination of genetic and neuroimaging tools to identify novel biomarkers of ..
  46. Nuclear Receptor Networks in Human Disease
    Frances Sladek; Fiscal Year: 2009
    ..Furthermore, several nuclear receptors are very effective drug targets, for both metabolic and mental disorders, making them among the most clinically relevant of all the transcription factors...
  47. Adolescent Psychopathology: Implications of Co-Morbidity
    Ann Vander Stoep; Fiscal Year: 2009
    ..Critical to the Healthy People 2010 objective of reducing the prevalence of mental disorders among young people is a clearer understanding of the developmental processes underlying childhood ..
  48. MENTAL HEALTH AND NURSE STAFFING IN US NURSING HOMES
    Sarah Myers; Fiscal Year: 2003
    Using 1998 data, we have estimated persons with mental disorders in U.S. nursing homes may now total approximately 1,000,000, or 67% of all residents...
  49. Understanding Health Disparities in the Progression of Type 2 Diabetes
    JAMES SIDNEY JACKSON; Fiscal Year: 2010
    ..studies have consistently found that blacks, in comparison to whites, have the same or lower rates of most mental disorders, even while experiencing higher rates of psychological distress...
  50. Preventing Youth Depression: A Multimedia Internet-Based Parent Program
    John R Seeley; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Depression is one of the most prevalent mental disorders to afflict adolescents. It seriously impacts role functioning and typically takes a recurrent or chronic course...
  51. Amphetamine Acts as a Molecular Stent in the Dopamine Transporter
    LOUIS DE FELICE; Fiscal Year: 2009
    ..Area (15) Translational Science and specific Challenge Topic, 15-MH-107: Targets for Drug Discovery for Mental Disorders. Amphetamine acts as a Molecular Stent in the Dopamine Transporter By introducing the term 'molecular ..
  52. Identification of an Epigenetic Risk Marker for PTSD
    Rachel Yehuda; Fiscal Year: 2010
    ..by applicant): This grant responds to NIH Challenge 08-MH-103: Understanding the Genomic Risk Architecture of Mental Disorders. This application builds on recent animal and human data on epigenetic mechanisms mediating '..
  53. Biomarkers for Outcomes In Late-life Depression (BOLD)
    Ian Cook; Fiscal Year: 2009
    ..Challenge Area (03) Biomarker Discovery and Validation, and specific Challenge Topic 03-MH-101: Biomarkers in mental disorders, in Project BOLD (Biomarkers for Outcomes In Late-life Depression)...
  54. Glucocorticoid mechanisms of neonatal separation effects on adult learning
    Aaron A Wilber; Fiscal Year: 2009
    ..will support the scientific integration of brain and behavior, to provide a foundation for understanding mental disorders, and will also define environmental risk for mental disorders...
  55. Amphetamine Acts as a Molecular Stent in the Dopamine Transporter
    Louis J De Felice; Fiscal Year: 2010
    ..Area (15) Translational Science and specific Challenge Topic, 15-MH-107: Targets for Drug Discovery for Mental Disorders. Amphetamine acts as a Molecular Stent in the Dopamine Transporter By introducing the term 'molecular ..
  56. Biomarkers for Outcomes In Late-life Depression (BOLD)
    Ian A Cook; Fiscal Year: 2010
    ..Challenge Area (03) Biomarker Discovery and Validation, and specific Challenge Topic 03-MH-101: Biomarkers in mental disorders, in Project BOLD (Biomarkers for Outcomes In Late-life Depression)...
  57. Preventing Youth Depression: A Multimedia Internet-Based Parent Program
    AMELIA BIRNEY; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Depression is one of the most prevalent mental disorders to afflict adolescents. It seriously impacts role functioning and typically takes a recurrent or chronic course...
  58. Identification of an Epigenetic Risk Marker for PTSD
    Rachel Yehuda; Fiscal Year: 2009
    ..by applicant): This grant responds to NIH Challenge 08-MH-103: Understanding the Genomic Risk Architecture of Mental Disorders. This application builds on recent animal and human data on epigenetic mechanisms mediating '..
  59. NEUROPHYSIOLOGICAL STUDIES OF SCHIZOPHRENIA
    ROBERT MC CARLEY; Fiscal Year: 2009
    ..NIMH area of interest - Translational Science: Innovative Targets and Models for Developing Treatments for Mental Disorders. The overall goal is the creation of an in vitro animal model of high frequency (gamma band;approx 40Hz) ..
  60. Developing a PET biomarker to predict response in treatment-resistant depression
    PATRICK MC GRATH; Fiscal Year: 2009
    ..Area (03): Biomarker Discovery and Validation and specific Challenge Topic, 03-MH-101: Biomarkers in mental disorders. While Major Depressive Disorder (MDD) is prevalent and disabling, compelling recent data from the Sequenced ..
  61. Discrimination, Parenting, & Resilience in Black Youth
    MIA S BYNUM; Fiscal Year: 2010
    ..the challenges presented by racial discrimination and how those processes lead to the presence or absence of mental disorders is poorly understood...
  62. Serotonin Genes & Individual Differences in Reward vs. Punishment-Based Learning
    Mark A Gluck; Fiscal Year: 2010
    ..Because many genes that are implicated in mental disorders also show naturally occurring variations in healthy individuals, understanding the function of these genes is ..
  63. Discrimination, Parenting, & Resilience in Black Youth
    MIA BYNUM; Fiscal Year: 2009
    ..the challenges presented by racial discrimination and how those processes lead to the presence or absence of mental disorders is poorly understood...
  64. THE TRANSCRIPTIONAL REGULATION OF MONOAMINE OXIDASE A
    Jean Shih; Fiscal Year: 2004
    The long-term objective of this project is to understand the role of monoamine oxidase A (MAO A) in mental disorders. MAO A is the key enzyme, which degrades serotonin (5-HT)...
  65. THE TRANSCRIPTIONAL REGULATION OF MONOAMINE OXIDASE A
    Jean Shih; Fiscal Year: 2007
    The long-term objective of this project is to understand the role of monoamine oxidase A (MAO A) in mental disorders. MAO A is the key enzyme, which degrades serotonin (5-HT)...
  66. THE TRANSCRIPTIONAL REGULATION OF MONOAMINE OXIDASE A
    Jean Shih; Fiscal Year: 2006
    The long-term objective of this project is to understand the role of monoamine oxidase A (MAO A) in mental disorders. MAO A is the key enzyme, which degrades serotonin (5-HT)...
  67. THE TRANSCRIPTIONAL REGULATION OF MONOAMINE OXIDASE A
    Jean Shih; Fiscal Year: 2005
    The long-term objective of this project is to understand the role of monoamine oxidase A (MAO A) in mental disorders. MAO A is the key enzyme, which degrades serotonin (5-HT)...
  68. Neuroimaging and Behavioral Biomarkers for ADHD in Children
    Martin Teicher; Fiscal Year: 2009
    ..Area 03: Biomarker Discovery and Validation, and the specific Challenge Topic 03-MH-101: Biomarkers in Mental Disorders. Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent behavioral disorder of childhood ..
  69. Neuroimaging and Behavioral Biomarkers for ADHD in Children
    Martin H Teicher; Fiscal Year: 2010
    ..Area 03: Biomarker Discovery and Validation, and the specific Challenge Topic 03-MH-101: Biomarkers in Mental Disorders. Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent behavioral disorder of childhood ..
  70. Social Aggression: Growth and Outcomes
    Marion K Underwood; Fiscal Year: 2010
    ..the development and consequences of social aggression may clarify the role of gender in emerging mental disorders, because girls engage in more social than physical aggression and social aggression might contribute to ..
  71. Social Aggression: Growth and Outcomes
    Marion Underwood; Fiscal Year: 2009
    ..the development and consequences of social aggression may clarify the role of gender in emerging mental disorders, because girls engage in more social than physical aggression and social aggression might contribute to ..
  72. BORNA VIRUS--AN EMERGING NEUROTROPIC PATHOGEN IN HUMANS
    JUAN DE LA TORRE; Fiscal Year: 1999
    ..indicates that persistent viral infections of the central nervous system (CNS) can contribute to human mental disorders of unknown etiology...
  73. BORNA VIRUS--AN EMERGING NEUROTROPIC PATHOGEN IN HUMANS
    JUAN DE LA TORRE; Fiscal Year: 2000
    ..indicates that persistent viral infections of the central nervous system (CNS) can contribute to human mental disorders of unknown etiology...
  74. Genetic Models of Serotonin Transporter Regulation Linked to Mental Disorders
    Sammanda Ramamoorthy; Fiscal Year: 2010
    ..drugs that block SERT such as tricyclic antidepressants and SSRIs are successfully used for the treatment of mental disorders. Studies from PI's group, collaborators and colleagues have identified signaling mechanisms of SERT ..
  75. AFrica Focus on Intervention Research for Mental health (AFFIRM)
    Ezra S Susser; Fiscal Year: 2011
    ..a Hub for research and capacity development to improve the delivery of cost effective interventions for mental disorders in sub-Saharan Africa...
  76. Testing a Comorbid PTSD & Substance/Alcohol Use Intervention in Delinquent Girls
    Amy E Lansing; Fiscal Year: 2010
    ..in juvenile delinquent populations where 67% - 75% have impairing psychiatric disorders, 20% have severe mental disorders and more than 1/3 need ongoing clinical MHS care- a figure twice the rate of the general adolescent ..
  77. Acute Impact of Antipsychotics on Insulin Sensitivity: A Novel Human Model
    Jonathan Meyer; Fiscal Year: 2009
    ..is related to the antipsychotic medications widely used for the treatment of schizophrenia and other major mental disorders, with ample data showing that antipsychotic exposure may be associated with insulin resistance and the ..
  78. Parsing the schizophrenia-bipolar spectrum: an MEG based schizoaffective endophen
    Martin Reite; Fiscal Year: 2010
    ..Challenge Area 03: Biomarker Discovery and Validation and specific Challenge Topic, 03-MH-101 "Biomarkers in mental disorders." The proposal is designed to develop a biomarker and physiological endophenotype for schizoaffective ..
  79. Parsing the schizophrenia-bipolar spectrum: an MEG based schizoaffective endophen
    Martin Reite; Fiscal Year: 2009
    ..Challenge Area 03: Biomarker Discovery and Validation and specific Challenge Topic, 03-MH-101 "Biomarkers in mental disorders." The proposal is designed to develop a biomarker and physiological endophenotype for schizoaffective ..
  80. Where do Eating Disorders belong in the Diagnostic Taxonomy?
    Kelsie Forbush; Fiscal Year: 2007
    Recent studies suggest that a dimensional, hierarchical model of mental disorders has clear advantages over a categorical nosology...
  81. MECHANISMS AND REGULATION OF 5-HT RECEPTORS IN THE CNS
    Rodrigo Andrade; Fiscal Year: 2009
    ..This neurotransmitter has also been implicated in mental disorders, especially anxiety and depression, and several pharmacological agents used to treat these diseases target ..
  82. Trait Fear and Disinhibition in Impulse Control Disorders
    CHRISTOPHER JOHN PATRICK; Fiscal Year: 2010
    ..Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic, 03-MH-101: Biomarkers in Mental Disorders. The application takes a construct-oriented approach to the identification of biomarkers for prevalent forms ..
  83. A Multimedia Program to Improve Antidepressant Adherence and Prevent Relapse
    MARTA MAKARUSHKA; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Major depression is one of the most prevalent mental disorders to afflict adults. It seriously impacts role functioning and typically takes a recurrent course...
  84. Trait Fear and Disinhibition in Impulse Control Disorders
    Christopher Patrick; Fiscal Year: 2009
    ..Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic, 03-MH-101: Biomarkers in Mental Disorders. The application takes a construct-oriented approach to the identification of biomarkers for prevalent forms ..
  85. TWO TYPES OF MONOAMINE OXIDASE
    Jean Shih; Fiscal Year: 1993
    ..Abnormal levels of MAO activity have been shown in a number of mental disorders. With the full-length human liver MAO A and B cDNAs cloned in this laboratory, the genomic organizations and ..
  86. Comparing Methods to Pay for Psychotropic Medications for Medicare Beneficiaries
    Yuting Zhang; Fiscal Year: 2009
    ..2, 3 The coverage gap may be particularly detrimental to Medicare beneficiaries with chronic mental disorders such as major depression, bipolar disorder, and schizophrenia, but we know almost nothing about how they ..
  87. Adherence Improvement and Measurement- AIM- System. Challenge Topic 10-MH-101
    James Kahn; Fiscal Year: 2009
    ..Data for Research and specific Challenge Topic, 10-MH-101: Technologies to improve treatment adherence for mental disorders and HIV/AIDS Persons receiving care in safety-net settings, with complex diseases and chronic conditions ..
  88. Evaluating Effectiveness of a Statewide Public Mental Health Re-entry Program
    Stephanie Hartwell; Fiscal Year: 2009
    ..and specific Challenge Topic, 09-MH-101: Validating Models of Community Re-entry Programs for Prisoners with Mental Disorders. Abstract The purpose of this study is to combine existing administrative databases to evaluate the ..
  89. CONTINUITY OF CARE & OUTCOME OF SEVERE MENTAL DISORDERS
    Ramin Mojtabai; Fiscal Year: 2003
    ..the principal investigator a career in mental health services research with a focus on patients with severe mental disorders. The candidate's long-term research goal is to apply the rigorous methods and analytic tools of epidemiology ..
  90. CONTINUITY OF CARE & OUTCOME OF SEVERE MENTAL DISORDERS
    Ramin Mojtabai; Fiscal Year: 1999
    ..the principal investigator a career in mental health services research with a focus on patients with severe mental disorders. The candidate's long-term research goal is to apply the rigorous methods and analytic tools of epidemiology ..
  91. CONTINUITY OF CARE & OUTCOME OF SEVERE MENTAL DISORDERS
    Ramin Mojtabai; Fiscal Year: 2002
    ..the principal investigator a career in mental health services research with a focus on patients with severe mental disorders. The candidate's long-term research goal is to apply the rigorous methods and analytic tools of epidemiology ..
  92. CONTINUITY OF CARE & OUTCOME OF SEVERE MENTAL DISORDERS
    Ramin Mojtabai; Fiscal Year: 2001
    ..the principal investigator a career in mental health services research with a focus on patients with severe mental disorders. The candidate's long-term research goal is to apply the rigorous methods and analytic tools of epidemiology ..
  93. MOLECULAR STUDIES OF MONOAMINE OXIDASES
    Jean Shih; Fiscal Year: 1990
    ..Abnormal levels of MAO activity have been shown in a number of mental disorders. With the full-length human liver MAO A and B cDNAs cloned in this laboratory, the genomic organizations and ..
  94. ANCHORING AND HALO BIASES IN DEPRESSION DIAGNOSIS
    GREGORY MUMMA; Fiscal Year: 1992
    ....