Genomes and Genes
Summary: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
Articles from Journal RESEARCH
Articles from Journal RESEARCH2
Publications328 found, 100 shown here
- Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: conceptual issues and research evidenceIlan H Meyer
Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Psychol Bull 129:674-97. 2003In this article the author reviews research evidence on the prevalence of mental disorders in lesbians, gay men, and bisexuals (LGBs) and shows, using meta-analyses, that LGBs have a higher prevalence of mental disorders than ..
- Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey ReplicationRonald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Gen Psychiatry 62:593-602. 2005..Little is known about lifetime prevalence or age of onset of DSM-IV disorders...
- Short screening scales to monitor population prevalences and trends in non-specific psychological distressR C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
Psychol Med 32:959-76. 2002..A 10-question screening scale of psychological distress and a six-question short-form scale embedded within the 10-question scale were developed for the redesigned US National Health Interview Survey (NHIS)...
- Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey ReplicationRonald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Gen Psychiatry 62:617-27. 2005Little is known about the general population prevalence or severity of DSM-IV mental disorders.
- The size and burden of mental disorders and other disorders of the brain in Europe 2010H U Wittchen
Institute of Clinical Psychology and Psychotherapy, Center of Epidemiology and Longitudinal Studies CELOS, Technische Universitat Dresden, Dresden, Germany
Eur Neuropsychopharmacol 21:655-79. 2011....
- Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health QuestionnaireR L Spitzer
Biometrics Research Department, New York State Psychiatric Institute, and Columbia University, New York 10032, USA
JAMA 282:1737-44. 1999The Primary Care Evaluation of Mental Disorders (PRIME-MD) was developed as a screening instrument but its administration time has limited its clinical usefulness.
- No health without mental healthMartin Prince
King s College London, Centre for Public Mental Health, Health Service and Population Research Department, Institute of Psychiatry, London, UK
Lancet 370:859-77. 2007..to neuropsychiatric disorders, mostly due to the chronically disabling nature of depression and other common mental disorders, alcohol-use and substance-use disorders, and psychoses...
- The endophenotype concept in psychiatry: etymology and strategic intentionsIrving I Gottesman
Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55454, USA
Am J Psychiatry 160:636-45. 2003..The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics...
- Screening for serious mental illness in the general populationRonald C Kessler
Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Suite 215, Boston, MA 02115, USA
Arch Gen Psychiatry 60:184-9. 2003..Public Law 102-321 established a block grant for adults with "serious mental illness" (SMI) and required the Substance Abuse and Mental Health Services Administration (SAMHSA) to develop a method to estimate the prevalence of SMI...
- Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health SurveysKoen Demyttenaere
JAMA 291:2581-90. 2004Little is known about the extent or severity of untreated mental disorders, especially in less-developed countries.
- Default-mode brain dysfunction in mental disorders: a systematic reviewSamantha J Broyd
Institute for Disorders of Impulse and Attention, Developmental Brain Behaviour Laboratory, School of Psychology, University of Southampton, UK
Neurosci Biobehav Rev 33:279-96. 2009..are concerned specifically with the putative role of the default-mode network (DMN) in the pathophysiology of mental disorders. First, we define the DMN concept with regard to its neuro-anatomy, its functional organisation through low ..
- The empirical status of cognitive-behavioral therapy: a review of meta-analysesAndrew C Butler
University of Pennsylvania and Beck Institute for Cognitive Therapy and Research, USA
Clin Psychol Rev 26:17-31. 2006..While limitations of the meta-analytic approach need to be considered in interpreting the results of this review, our findings are consistent with other review methodologies that also provide support for the efficacy CBT...
- Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practiceMadhukar H Trivedi
Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Rd, Suite 1300, Dallas, TX 75390 9119, USA
Am J Psychiatry 163:28-40. 2006....
- Smoking and mental illness: A population-based prevalence studyK Lasser
Department of Medicine, Cambridge Hospital, Macht Bldg, 1493 Cambridge St, Cambridge, MA 02139, USA
JAMA 284:2606-10. 2000..However, recent population-based, nationally representative data are lacking...
- Prevalence and development of psychiatric disorders in childhood and adolescenceE Jane Costello
Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC 27710, USA
Arch Gen Psychiatry 60:837-44. 2003..This longitudinal community study assessed the prevalence and development of psychiatric disorders from age 9 through 16 years and examined homotypic and heterotypic continuity...
- The treatment gap in mental health careRobert Kohn
Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
Bull World Health Organ 82:858-66. 2004b>Mental disorders are highly prevalent and cause considerable suffering and disease burden. To compound this public health problem, many individuals with psychiatric disorders remain untreated although effective treatments exist...
- Poverty and mental disorders: breaking the cycle in low-income and middle-income countriesCrick Lund
Centre for Public Mental Health, Department of Psychiatry and Mental Health, University of Cape Town, South Africa
Lancet 378:1502-14. 2011..This study supports the call to scale up mental health care, not only as a public health and human rights priority, but also as a development priority...
- Twelve-month use of mental health services in the United States: results from the National Comorbidity Survey ReplicationPhilip S Wang
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Gen Psychiatry 62:629-40. 2005..Dramatic changes have occurred in mental health treatments during the past decade. Data on recent treatment patterns are needed to estimate the unmet need for services...
- Mental health of young people: a global public-health challengeVikram Patel
Department of Epidemiology and Public Health, London School of Hygiene and Tropical Medicine, London, UK
Lancet 369:1302-13. 2007b>Mental disorders account for a large proportion of the disease burden in young people in all societies. Most mental disorders begin during youth (12-24 years of age), although they are often first detected later in life...
- Suicide prevention strategies: a systematic reviewJ John Mann
New York State Psychiatric Institute, Division of Neuroscience, New York, NY 10032, USA
JAMA 294:2064-74. 2005..Some developed nations have implemented national suicide prevention plans. Although these plans generally propose multiple interventions, their effectiveness is rarely evaluated...
- Psychosocial work environment and mental health--a meta-analytic reviewStephen Stansfeld
Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Joseph Rotblat Building, Barts and London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1 6BQ, United Kindom
Scand J Work Environ Health 32:443-62. 2006..between psychosocial work stressors and mental ill health, a meta-analysis of psychosocial work stressors and common mental disorders was undertaken using longitudinal studies identified through a systematic literature review.
- Long term sickness absenceMax Henderson
BMJ 330:802-3. 2005
- Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveysPhilip S Wang
Division of Services and Intervention Research, National Institute of Mental Health, Rockville, MD, USA
Lancet 370:841-50. 2007b>Mental disorders are major causes of disability worldwide, including in the low-income and middle-income countries least able to bear such burdens...
- Interpreting scores on the Kessler Psychological Distress Scale (K10)G Andrews
World Health Organization Collaborating Centre in Evidence for Mental Health Policy and School of Psychiatry, University of New South Wales at St Vincent s Hospital, Darlinghurst
Aust N Z J Public Health 25:494-7. 2001..To provide normative data on the Kessler Psychological Distress Scale (K10), a scale that is being increasingly used for clinical and epidemiological purposes...
- Association between physical activity and mental disorders among adults in the United StatesRenee D Goodwin
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
Prev Med 36:698-703. 2003The objective of this study was to determine the association between regular physical activity and mental disorders among adults in the United States.
- Resources for mental health: scarcity, inequity, and inefficiencyShekhar Saxena
World Health Organization, Geneva, Switzerland
Lancet 370:878-89. 2007..health in most of the relevant countries is far lower than is needed, based on the proportionate burden of mental disorders and the availability of cost-effective and affordable interventions...
- The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI)Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
Int J Methods Psychiatr Res 13:93-121. 2004..Elaborate CD-ROM-based training materials are available to teach interviewers how to administer the interview as well as to teach supervisors how to monitor the quality of data collection...
- Size and burden of mental disorders in Europe--a critical review and appraisal of 27 studiesHans Ulrich Wittchen
Clinical Psychology and Psychotherapy, Technical University of Dresden, Dresden, Germany
Eur Neuropsychopharmacol 15:357-76. 2005Epidemiological data on a wide range of mental disorders from community studies conducted in European countries are presented to determine the availability and consistency of prevalence, disability and treatment findings for the EU...
- Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohortJulia Kim-Cohen
Institute of Psychiatry, King s College, London, England
Arch Gen Psychiatry 60:709-17. 2003If most adults with mental disorders are found to have a juvenile psychiatric history, this would shift etiologic research and prevention policy to focus more on childhood mental disorders.
- Prevalence, co-morbidity and correlates of mental disorders in the general population: results from the German Health Interview and Examination Survey (GHS)F Jacobi
Institute of Clinical Psychology and Psychotherapy, Unit Epidemiology and Service Research, Technical University of Dresden, Germany
Psychol Med 34:597-611. 2004..GHS) is the first government mandated nationwide study to investigate jointly the prevalence of somatic and mental disorders within one study in the general adult population in Germany...
- Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk predictionM Ayalew
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
Mol Psychiatry 17:887-905. 2012..It also reveals the significant genetic overlap with other major psychiatric disorder domains, suggesting the need for improved nosology...
- Relative risk of cardiovascular and cancer mortality in people with severe mental illness from the United Kingdom's General Practice Rsearch DatabaseDavid P J Osborn
Department of Mental Health Sciences, Royal Free Medical School, London, England
Arch Gen Psychiatry 64:242-9. 2007..People with severe mental illness (SMI) appear to have an elevated risk of death from cardiovascular disease, but results regarding cancer mortality are conflicting...
- The Composite International Diagnostic Interview. An epidemiologic Instrument suitable for use in conjunction with different diagnostic systems and in different culturesL N Robins
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110
Arch Gen Psychiatry 45:1069-77. 1988..If all goes well, the CIDI will allow investigators reliably to assess mental disorders according to the most widely accepted nomenclatures in many different populations and cultures.
- Combat duty in Iraq and Afghanistan, mental health problems, and barriers to careCharles W Hoge
Department of Psychiatry and Behavioral Sciences, Walter Reed Army Institute of Research, U S Army Medical Research and Materiel Command, Silver Spring, MD 20910, USA
N Engl J Med 351:13-22. 2004....
- Recurrence of sickness absence due to common mental disordersPetra C Koopmans
ArboNed Occupational Health Services Statistics, PO Box 141, 9700 AC, Groningen, The Netherlands
Int Arch Occup Environ Health 84:193-201. 2011Common mental disorders (CMDs) are an important cause of work disability. Although CMDs are known to have high recurrence rates, little is known about the recurrence of sickness absence due to CMDs...
- Moving towards a population health approach to the primary prevention of common mental disordersFelice N Jacka
Deakin University, School of Medicine and Barwon Health, PO Box 281, Geelong 3220, Australia
BMC Med 10:149. 2012There is a need for the development of effective universal preventive approaches to the common mental disorders, depression and anxiety, at a population level...
- Self-reported attenuated psychotic symptoms as forerunners of severe mental disorders later in lifeNomi Werbeloff
Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Israel
Arch Gen Psychiatry 69:467-75. 2012..It has been suggested that attenuated psychotic symptoms (APSs) reported by people who do not have psychotic disorders signal risk for later severe mental illness...
- Costs of nine common mental disorders: implications for curative and preventive psychiatryFilip Smit
Trimbos Institute Netherlands Institute of Mental Health and Addiction, P O Box 725, 2500 AS Utrecht, The Netherlands
J Ment Health Policy Econ 9:193-200. 2006b>Mental disorders are highly prevalent and are associated with substantial disease burden, but their economic costs have been relatively less well researched...
- The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveysRonald C Kessler
Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
Epidemiol Psichiatr Soc 18:23-33. 2009The paper reviews recent findings from the WHO World Mental Health (WMH) surveys on the global burden of mental disorders.
- Common mental disorders among HIV-infected individuals in South Africa: prevalence, predictors, and validation of brief psychiatric rating scalesLandon Myer
Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
AIDS Patient Care STDS 22:147-58. 2008Despite the high prevalence of both mental disorders and HIV infection in much of sub-Saharan Africa, little is known about the occurrence of mental health disorders among HIV-infected individuals...
- The DISC locus in psychiatric illnessJ E Chubb
Medical Genetics Section, The Centre for Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, UK
Mol Psychiatry 13:36-64. 2008..DISC1 is a hub protein in a multidimensional risk pathway for major mental illness, and studies of this pathway are opening up opportunities for a better understanding of causality and possible mechanisms of intervention...
- Prognostic factors of long term disability due to mental disorders: a systematic reviewL R Cornelius
Department of Health Sciences, Section of Social Medicine, Work and Health, University Medical Center Groningen, Antonius Deusinglaan, The Netherlands
J Occup Rehabil 21:259-74. 2011..Recommendations are made as to directions and methodological quality of further research, i.e., prognostic cohort studies...
- Prevalence and treatment of mental disorders, 1990 to 2003Ronald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 352:2515-23. 2005Although the 1990s saw enormous change in the mental health care system in the United States, little is known about changes in the prevalence or rate of treatment of mental disorders.
- Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication--Adolescent Supplement (NCS-A)Kathleen Ries Merikangas
Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
J Am Acad Child Adolesc Psychiatry 49:980-9. 2010To present estimates of the lifetime prevalence of DSM-IV mental disorders with and without severe impairment, their comorbidity across broad classes of disorder, and their sociodemographic correlates.
- Association between obesity and psychiatric disorders in the US adult populationGregory E Simon
Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
Arch Gen Psychiatry 63:824-30. 2006..Epidemiologic data suggest an association between obesity and depression, but findings vary across studies and suggest a stronger relationship in women than men...
- Treatment and prevention of mental disorders in low-income and middle-income countriesVikram Patel
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
Lancet 370:991-1005. 2007We review the evidence on effectiveness of interventions for the treatment and prevention of selected mental disorders in low-income and middle-income countries...
- Social capital and mental illness: a systematic reviewMary J De Silva
Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
J Epidemiol Community Health 59:619-27. 2005..This papers aims to systematically review quantitative studies examining the association between social capital and mental illness...
- Domestic violence and perinatal mental disorders: a systematic review and meta-analysisLouise M Howard
Section of Women s Mental Health, Institute of Psychiatry, King s College London, London, UK
PLoS Med 10:e1001452. 2013..is associated with adverse obstetric outcomes, but evidence is limited on its association with perinatal mental disorders. We aimed to estimate the prevalence and odds of having experienced domestic violence among women with ..
- Mental disorders in megacities: findings from the São Paulo megacity mental health survey, BrazilLaura Helena Andrade
Section of Psychiatric Epidemiology LIM 23, Department and Institute of Psychiatry, University of Sao Paulo Medical School, Sao Paulo, Brazil
PLoS ONE 7:e31879. 2012..São Paulo Metropolitan Area (SPMA) provides a forewarning of the burden of mental disorders in urban settings in developing world...
- Excess mortality, causes of death and life expectancy in 270,770 patients with recent onset of mental disorders in Denmark, Finland and SwedenMerete Nordentoft
Psychiatric Centre Copenhagen, University of Copenhagen, Faculty of Health Sciences, Copenhagen, Denmark
PLoS ONE 8:e55176. 2013Excess mortality among patients with severe mental disorders has not previously been investigated in detail in large complete national populations.
- Experiences of domestic violence and mental disorders: a systematic review and meta-analysisKylee Trevillion
Section of Women s Mental Health, Health Service and Population Research Department, Institute of Psychiatry, King s College London, London, United Kingdom
PLoS ONE 7:e51740. 2012Little is known about the extent to which being a victim of domestic violence is associated with different mental disorders in men and women...
- Cognitive bias modification procedures in the management of mental disordersColin MacLeod
Centre for the Advancement of Research on Emotion, School of Psychology, The University of Western Australia, Perth, Western Australia, Australia
Curr Opin Psychiatry 25:114-20. 2012....
- Common mental disorders in TB/HIV co-infected patients in EthiopiaAmare Deribew
Department of Epidemiology, Jimma University, Jimma, Ethiopia
BMC Infect Dis 10:201. 2010The relationship between TB/HIV co-infection and common mental disorders (CMD) has been scarcely investigated. In this study, we compared the occurrence of CMD in TB/HIV co-infected and non-co-infected HIV patients in Ethiopia.
- Trends and risk factors for mental health diagnoses among Iraq and Afghanistan veterans using Department of Veterans Affairs health care, 2002-2008Karen H Seal
San Francisco VA Medical Center, San Francisco, CA 94121, USA
Am J Public Health 99:1651-8. 2009..We sought to investigate longitudinal trends and risk factors for mental health diagnoses among Iraq and Afghanistan veterans...
- Outcomes of Nordic mental health systems: life expectancy of patients with mental disordersKristian Wahlbeck
Nordic School of Public Health, Nordic Research Academy in Mental Health, Gothenburg, Sweden, and National Institute for Health and Welfare THL, Vaasa, Finland
Br J Psychiatry 199:453-8. 2011People with mental disorders evince excess mortality due to natural and unnatural deaths. The relative life expectancy of people with mental disorders is a proxy measure of effectiveness of social policy and health service provision.
- Prevalence of serious mental disorder in 7000 refugees resettled in western countries: a systematic reviewMina Fazel
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
Lancet 365:1309-14. 2005..We did a systematic review of surveys about these disorders in general refugee populations in western countries...
- Detecting common mental disorders in primary care in India: a comparison of five screening questionnairesV Patel
London School of Hygiene and Tropical Medicine, London, UK
Psychol Med 38:221-8. 2008Screening of patients for common mental disorders (CMDs) is needed in primary-care management programmes. This study aimed to compare the screening properties of five widely used questionnaires.
- Global pattern of experienced and anticipated discrimination against people with schizophrenia: a cross-sectional surveyGraham Thornicroft
Health Service and Population Research Department, Institute of Psychiatry, King s College London, UK
Lancet 373:408-15. 2009..We aimed to describe the nature, direction, and severity of anticipated and experienced discrimination reported by people with schizophrenia...
- Scale up services for mental disorders: a call for actionD Chisholm
Lancet 370:1241-52. 2007..stakeholders, such as professional bodies and consumer groups, to scale up the coverage of services for mental disorders in all countries, but especially in low-income and middle-income countries...
- The epidemiology of excess mortality in people with mental illnessDavid Lawrence
Centre for Developmental Health, Curtin University of Technology and Telethon Institute for Child Health Research, Perth, Australia
Can J Psychiatry 55:752-60. 2010..to investigate the burden of excess mortality among people with mental illness in developed countries, how it is distributed, and whether it has changed over time...
- Common perinatal mental disorders in northern Viet Nam: community prevalence and health care useJane Fisher
Centre for Women s Health, Gender and Society, University of Melbourne, Carlton, Vic, 3010, Australia
Bull World Health Organ 88:737-45. 2010To establish the prevalence of common perinatal mental disorders their determinants, and their association with preventive health care use among women in one rural and one urban province in northern Viet Nam.
- The performance of the Japanese version of the K6 and K10 in the World Mental Health Survey JapanToshi A Furukawa
Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Int J Methods Psychiatr Res 17:152-8. 2008..Composite International Diagnostic Interview (CIDI) to assess the 30-day Diagnostic and Statistical Manual of Mental Disorders--Fourth Edition (DSM-IV)...
- Failure and delay in initial treatment contact after first onset of mental disorders in the National Comorbidity Survey ReplicationPhilip S Wang
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Gen Psychiatry 62:603-13. 2005..An understudied crucial step in the help-seeking process is making prompt initial contact with a treatment provider after first onset of a mental disorder...
- Childhood adversities and adult psychopathology in the WHO World Mental Health SurveysRonald C Kessler
Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
Br J Psychiatry 197:378-85. 2010Although significant associations of childhood adversities with adult mental disorders are widely documented, most studies focus on single childhood adversities predicting single disorders.
- Problem-solving therapy for depression and common mental disorders in Zimbabwe: piloting a task-shifting primary mental health care intervention in a population with a high prevalence of people living with HIVDixon Chibanda
Department of Psychiatry, University of Zimbabwe, Harare, Zimbabwe
BMC Public Health 11:828. 2011There is limited evidence that interventions for depression and other common mental disorders (CMD) can be integrated sustainably into primary health care in Africa...
- Promoting child and adolescent mental health in low and middle income countriesVikram Patel
London School of Hygiene and Tropical Medicine and Sangath, India
J Child Psychol Psychiatry 49:313-34. 2008..We also consider the role of formal teaching and training programmes, and the role for specialists in CAMH promotion...
- Perceived barriers and facilitators to mental health help-seeking in young people: a systematic reviewAmelia Gulliver
Centre for Mental Health Research, The Australian National University, Canberra, Australia
BMC Psychiatry 10:113. 2010Adolescents and young adults frequently experience mental disorders, yet tend not to seek help...
- When and how do young people seek professional help for mental health problems?Debra J Rickwood
School of Health Sciences, University of Canberra, Canberra, ACT, Australia
Med J Aust 187:S35-9. 2007..Increasingly, Internet-based information and interventions are being used to engage young people in the help-seeking process...
- A Norwegian psychiatric epidemiological studyE Kringlen
Department of Psychiatry, University of Oslo, Norway
Am J Psychiatry 158:1091-8. 2001..The mean age of the interviewed subjects was 39.3 years. RESULTS: The 12-month prevalence of all mental disorders was 32.8%, and the lifetime prevalence was 52.4%...
- Atypical antipsychotic drugs and the risk of sudden cardiac deathWayne A Ray
Division of Pharmacoepidemiology, Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville 37212, USA
N Engl J Med 360:225-35. 2009..However, less is known regarding the cardiac safety of the atypical antipsychotic drugs, which have largely replaced the older agents in clinical practice...
- The diagnosis of mental disorders: the problem of reificationSteven E Hyman
Department of Neurobiology, Harvard Medical School, Harvard University, Cambridge, Massachusetts 02138, USA
Annu Rev Clin Psychol 6:155-79. 2010A pressing need for interrater reliability in the diagnosis of mental disorders emerged during the mid-twentieth century, prompted in part by the development of diverse new treatments...
- Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related ConditionsDeborah S Hasin
Mailman School of Public Health, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Arch Gen Psychiatry 64:830-42. 2007..Epidemiologic information is important to inform etiological research and service delivery planning. However, current information on the epidemiology of alcohol use disorders in the United States is lacking...
- Toward a clinical model of suicidal behavior in psychiatric patientsJ J Mann
Mental Health Clinical Research Center for the Study of Suicidal Behavior, Department of Neuroscience, New York State Psychiatric Institute, New York 10032, USA
Am J Psychiatry 156:181-9. 1999....
- Cross-national prevalence and risk factors for suicidal ideation, plans and attemptsMatthew K Nock
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Br J Psychiatry 192:98-105. 2008..Suicide is a leading cause of death worldwide; however, the prevalence and risk factors for the immediate precursors to suicide - suicidal ideation, plans and attempts - are not wellknown, especially in low- and middle-income countries...
- Distinguishing between the validity and utility of psychiatric diagnosesRobert Kendell
Department of Psychiatry and Behavioural Science, University of Western Australia, Perth, Australia
Am J Psychiatry 160:4-12. 2003..The meaning of the terms "validity" and "utility" as they apply to psychiatric diagnoses is examined...
- DISC1 at 10: connecting psychiatric genetics and neuroscienceDavid J Porteous
Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Trends Mol Med 17:699-706. 2011....
- Cross-national associations between gender and mental disorders in the World Health Organization World Mental Health SurveysSoraya Seedat
Medical Research Council Research Unit on Anxiety and Stress Disorder, Cape Town, South Africa
Arch Gen Psychiatry 66:785-95. 2009Gender differences in mental disorders, including more anxiety and mood disorders among women and more externalizing disorders among men, are found consistently in epidemiological surveys...
- The burden of mental disordersWilliam W Eaton
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Epidemiol Rev 30:1-14. 2008..interest in the burden of chronic and disabling health conditions that are not necessarily fatal, such as the mental disorders. This review systematically summarizes data on the burden associated with 11 major mental disorders of adults...
- Experience sampling research in psychopathology: opening the black box of daily lifeI Myin-Germeys
Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
Psychol Med 39:1533-47. 2009....
- Psychiatric comorbidity in patients with chronic daily headache and migraine: a selective overview including personality traits and suicide riskMaurizio Pompili
Department of Psychiatry, Sant Andrea Hospital, Sapienza University of Rome, 1035 Via di Grottarossa, Rome 00189, Italy
J Headache Pain 10:283-90. 2009..The increase in self-efficacy and mental health associated with pharmaceutical care may be instrumental in improving the long-term pharmacotherapy of patients with migraine and headache...
- The mental wealth of nationsJohn Beddington
Government Office for Science, London
Nature 455:1057-60. 2008..Countries must learn how to capitalize on their citizens' cognitive resources if they are to prosper, both economically and socially. Early interventions will be key...
- Copy-number variations associated with neuropsychiatric conditionsEdwin H Cook
Institute for Juvenile Research, Department of Psychiatry, University of Illinois, 1747 West Roosevelt Road, Chicago, Illinois 60608, USA
Nature 455:919-23. 2008..The complexity of neuropsychiatric genetics, however, dictates that assessment of the biomedical relevance of copy-number variants and the genes that they affect needs to be considered in an integrated context...
- Prevalence, treatment, and associated disability of mental disorders in four provinces in China during 2001-05: an epidemiological surveyMichael R Phillips
WHO Collaborating Centre for Research and Training in Suicide Prevention, Beijing Hui Long Guan Hospital, Beijing, China
Lancet 373:2041-53. 2009..country-specific data for the prevalence, treatment, and associated disability of different types of mental disorders. We therefore estimated these variables from a series of epidemiological studies that were done in four ..
- Individual and societal effects of mental disorders on earnings in the United States: results from the national comorbidity survey replicationRonald C Kessler
Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
Am J Psychiatry 165:703-11. 2008The purpose of this report was to update previous estimates of the association between mental disorders and earnings. Current estimates for 2002 are based on data from the National Comorbidity Survey Replication (NCS-R).
- Poverty and common mental disorders in low and middle income countries: A systematic reviewCrick Lund
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
Soc Sci Med 71:517-28. 2010..of high levels of poverty in low and middle income countries (LMIC), and the high burden posed by common mental disorders (CMD), it is only in the last two decades that research has emerged that empirically addresses the ..
- Neuroeconomic approaches to mental disordersKenneth T Kishida
Department of Neuroscience and Computational Psychiatry Unit, Baylor College of Medicine, Houston, TX 77030, USA
Neuron 67:543-54. 2010..This review surveys the recent and productive application of game-theoretic probes (economic games) to mental disorders. Such games typically possess concrete concepts of optimal play, thus providing quantitative ways to track ..
- Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjectsYogesh Dwivedi
Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
Arch Gen Psychiatry 60:804-15. 2003....
- Risk for psychopathology in the children of depressed mothers: a developmental model for understanding mechanisms of transmissionS H Goodman
Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
Psychol Rev 106:458-90. 1999..Relevant issues are discussed, and promising directions for future research are suggested...
- Obesity among those with mental disorders: a National Institute of Mental Health meeting reportDavid B Allison
University of Alabama at Birmingham, Birmingham, Alabama, USA
Am J Prev Med 36:341-50. 2009..in October 2005 to review the literature on obesity, nutrition, and physical activity among those with mental disorders. The findings of this meeting and subsequent update of the literature review are summarized here...
- Generalizability studies of the Global Assessment of Functioning-Split versionGeir Pedersen
Department of Personality Psychiatry, Ulleval University Hospital, 0407 Oslo, Norway
Compr Psychiatry 48:88-94. 2007..The study aimed to use the Generalizability Theory to investigate the reliability and precision of the split version of the Global Assessment of Functioning (GAF)...
- Population level of unmet need for mental healthcare in EuropeJordi Alonso
Health Services Research Unit, Institut Municipal d Investigacio Medica, Carrer del Doctor Aiguader, 88 E 08003 Barcelona, Spain
Br J Psychiatry 190:299-306. 2007The high prevalence of mental disorders has fuelled controversy about the need for mental health services.
- Lifetime prevalence of gender-based violence in women and the relationship with mental disorders and psychosocial functionSusan Rees
School of Psychiatry, University of New South Wales, and Center for Population Mental Health Research, Liverpool Hospital, Sydney South West Area Health Network, Sydney, New South Wales, Australia 2170
JAMA 306:513-21. 2011..An association between these forms of abuse and lifetime mental disorder and psychosocial disability among women needs to be examined...
- Russian child mental health--a cross-sectional study of prevalence and risk factorsRobert Goodman
Dept of Child and Adolescent Psychiatry, Institute of Psychiatry, King s College London, London SE5 8AF, UK
Eur Child Adolesc Psychiatry 14:28-33. 2005..The fall of communism and subsequent economic crises have been followed by major social and health problems. High rates of child mental health problems are frequently cited by the Russian media, though there is little relevant evidence...
- A brief case-finding questionnaire for common mental disorders: the CMDQKaj Sparle Christensen
The Research Unit for General Practice, University of Aarhus, Denmark
Fam Pract 22:448-57. 2005The aim of the study was to validate a new case-finding instrument for common mental disorders (CMDQ).
- NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnosesD Shaffer
Division of Child and Adolescent Psychiatry, Columbia University, New York 10032, USA
J Am Acad Child Adolesc Psychiatry 39:28-38. 2000..The interview is available in both English and Spanish versions...
- Prolonged grief disorder: Psychometric validation of criteria proposed for DSM-V and ICD-11Holly G Prigerson
Department of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
PLoS Med 6:e1000121. 2009....
- Concordance of the Composite International Diagnostic Interview Version 3.0 (CIDI 3.0) with standardized clinical assessments in the WHO World Mental Health surveysJosep Maria Haro
Int J Methods Psychiatr Res 15:167-80. 2006..The validity of the CIDI is likely to be under-estimated in these comparisons due to the fact that the reliability of the SCID diagnoses, which is presumably less than perfect, sets a ceiling on maximum CIDI-SCID concordance...
- Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesisKarestan C Koenen
Department of Society, Human Development, and Health, Harvard School of Public Health, Kresge 613, 677 Huntington Ave, Boston, MA 02115, USA
Am J Psychiatry 166:50-7. 2009..However, tests of the association between premorbid IQ and adult mental disorders other than schizophrenia have been limited and inconclusive...
- The British Child and Adolescent Mental Health Survey 1999: the prevalence of DSM-IV disordersTamsin Ford
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Denmark Hill, London SE58AF, England
J Am Acad Child Adolesc Psychiatry 42:1203-11. 2003..To describe the prevalence of DSM-IV disorders and comorbidity in a large population-based sample of British children and adolescents...
- An examination of premature mortality among decedents with serious mental illness and those in the general populationELIZABETH E PIATT
Department of Behavioral and Community Health Sciences, NortheasternOhio Universities Colleges of Medicine and Pharmacy, 4209 State Route 44, Rootstown, OH 44272, USA
Psychiatr Serv 61:663-8. 2010....
- Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disordersJennifer Greif Green
Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
Arch Gen Psychiatry 67:113-23. 2010Although significant associations of childhood adversities (CAs) with adult mental disorders have been documented consistently in epidemiological surveys, these studies generally have examined only 1 CA per study...
- CRF-Oxytocin Interaction in the Regulation of Stress and AffectJoanna Dabrowska; Fiscal Year: 2013..My career objective is to conduct independent research to understand how stress and affect interact and elucidate their respective roles in the etiology of mental disorders like depression and anxiety.
- Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer'sPadmakar Kulkarni; Fiscal Year: 2010..RFA-OD-09-003) 03- MH-101, Biomarkers in mental disorders. The goal of the proposal is to develop biomarkers for the detection of amyloid plaques in living humans...
- Epigenomic Events in Development of the Locus Coeruleus Noradrenergic NeuronsJan Krzysztof Blusztajn; Fiscal Year: 2012..in neurodevelopmental processes and to identify epigenome-wide marks associated with vulnerability to mental disorders. The proposed studies will address cell specificity in the brain across development, and focus on how several ..
- Cell stress, development, and stimulant-induced behavior: Regulation by GSK3Marjelo A Mines; Fiscal Year: 2012..Progress in reducing the prevalence and severity of mental disorders requires coalescence of multiple strategies...
- Validation of a functional MRI-based reward processing task as a non-invasive tooMARY LOUISE PHILLIPS; Fiscal Year: 2010..Area (03) Biomarker Discovery and Validation and specific Challenge topic, 03-MH-101*: Biomarkers in mental disorders. Psychiatric Disorders such as alcohol and other substance abuse disorders, unipolar depression, bipolar ..
- Environmental regulation of estrogen dependent aggressionBrian C Trainor; Fiscal Year: 2013..Dysregulated aggression is a component of mental disorders including bipolar disorder, schizophrenia, and borderline personality disorder...
- Safety signal learning in Rhesus monkeys following early life stressChallenge ArMICHAEL NMN DAVIS; Fiscal Year: 2010..Area (01) Behavior, Behavioral Change, and Prevention and specific Challenge Topic 03-MH-101* Biomarkers in mental disorders. The major hypothesis is that post-traumatic stress disorder (PTSD) leads to a reduction in the ability to ..
- Anxiety development in 5-HT1A autoreceptor knockout mice, interaction with stressRene Hen; Fiscal Year: 2010..Area (15) Translational Science, Gene x environment x development (GxExD) studies of brain function and mental disorders. Gene x environment epidemiology and psychiatry research studies have only recently been used and the ..
- Neuroendocrine Mechanisms and Therapeutics in an Animal Model of PTSDDAVID MARK DIAMOND; Fiscal Year: 2013..understanding of the etiology of stress-induced sequelae and how to effectively treat stress-related mental disorders. This research will enhance our understanding of the neurobiology of traumatic memory processing and aid in ..
- Derivation of cerebral cortical GABAergic interneurons from human iPS cellsLorenz P Studer; Fiscal Year: 2010..Specific challenge topic 14-MH-101: Developing iPS cells for mental disorders. Dysfunction of GABAergic interneurons of the cerebral cortex has been implicated in a variety of major ..
- Inflammation and Sub-Clinical Renal Damage in Cocaine-Dependent African AmericansELIZABETH GROOMS NESMITH; Fiscal Year: 2010..will be defined using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) Axis I Disorders (SCID), and by self-report of cocaine use for at least 4 days out of the last 30 ..
- Role of histone acetyltransferases in memory storage and synaptic plasticityMARCEL ANDRE ESTEVEZ; Fiscal Year: 2012..the brain, is thought to underlie memory storage and may play a crucial role in a variety of neurological and mental disorders, including Alzheimer's disease, mental retardation, epilepsy and depression...
- Effect of D-cycloserine on treatment of PTSD in youthMichael S Scheeringa; Fiscal Year: 2010..and Specific Challenge Topic "04-MH-103: Interventions That Target Symptom Dimensions of Childhood-Onset Mental Disorders." The family of cognitive-behavioral therapies (CBT) is a recommended intervention for posttraumatic stress ..
- Integrated PTSD and Smoking TreatmentMark B Powers; Fiscal Year: 2013..2 In fact, the quit rate in smokers with PTSD (23.2%) is one of the lowest of all mental disorders.8Thus, the vast majority of persons with PTSD attempting to quit smoking do not benefit from existing ..
- CHOLINERGIC MECHANISMS OF REM SLEEP GENERATIONHelen A Baghdoyan; Fiscal Year: 2013..that 450 million people worldwide suffer from some form of mental or brain disorder, and that in the West mental disorders account for 80% of premature deaths in young adults...
- A translational model of neuro-immune therapy for PTSD in veterans of the OEF/OIFLeonardo H Tonelli; Fiscal Year: 2013..Operation Enduring Freedom/Operation Iraqi Freedom) have a particularly high incidence of PTSD and other mental disorders such as anxiety and mood disorders...
- Developing Novel Dual CRF-R1/Orexin-1 Receptor Antagonists for Tobacco DependenceBelew Mekonnen; Fiscal Year: 2011..has been implicated in complex major health disorders such as cancer, stroke, cardiovascular diseases, and mental disorders. In the USA alone, 30% of all cancer deaths and 87% of all lung cancer deaths are reported to be tobacco-use ..
- Mechanisms Underlying Social Cooperative BehaviorLUKE JOSEPH CHANG; Fiscal Year: 2010..mission to advance the integration of behavior and brain science to provide a greater understanding of mental disorders, this proposal combines theories and methods from the diverse fields of psychology, economics, and ..
- Identification of an Epigenetic Risk Marker for PTSDRachel Yehuda; Fiscal Year: 2010..by applicant): This grant responds to NIH Challenge 08-MH-103: Understanding the Genomic Risk Architecture of Mental Disorders. This application builds on recent animal and human data on epigenetic mechanisms mediating '..
- Role of T Cell Mediated Immunity In Emotion And Stress ResponsivenessLeonardo H Tonelli; Fiscal Year: 2012..This may advance the understanding of mind-body interaction and lead to the development of new strategies of interventions to improve the treatment of mental disorders in chronically ill patients.
- A twin study of ovarian hormones and disordered eatingKelly L Klump; Fiscal Year: 2012..sex hormone, and genetic factors contributing to sex differences in the prevalence and etiology of mental disorders. Bulimic syndromes are much more prevalent in women than men and may exhibit genetic influence only after sex ..
- Adolescent Alcohol,Dysregulated Stress System, and PTSD VulnerabilityGERHARD H SCHULTEIS; Fiscal Year: 2013..S. population, a recent study reported that PTSD represents nearly half of all mental disorders for veterans of Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF)...
- Nuclear Receptor Networks in Human DiseaseFrances M Sladek; Fiscal Year: 2010..Furthermore, several nuclear receptors are very effective drug targets, for both metabolic and mental disorders, making them among the most clinically relevant of all the transcription factors...
- miR132 regulation of neuronal plasticity, learning, and memoryKATELIN L F HANSEN; Fiscal Year: 2013..In sum, a more complete understanding of miR132's role in neuronal signaling and cognition should further our efforts to develop novel therapeutic strategies for the treatment of a variety of mental disorders.
- Effects of Alcohol on Stem Cells in the Adult BrainMichael W Miller; Fiscal Year: 2012..g., dementia and Korsakoff's Syndrome, and it is a co-morbid factor in many diseases including mental disorders and hepatoencephalopathy...
- GENE EXPRESSION EXON ARRAY BIOMARKERS TO DIAGNOSE SCHIZOPHRENIATerry W Osborn; Fiscal Year: 2010..effort may alter medical treatment by providing more effective drugs, appropriate early interventions for mental disorders. The specific objective of this pilot study is to demonstrate predictive and, consistent surrogate biomarkers ..
- Effects on Caffeine on Adolescent Behavior and PhysiologyJennifer L Temple; Fiscal Year: 2010..is addictive, a subset of adult and adolescent caffeine users meet the Diagnostic and Statistical Manual for Mental Disorders-IV criteria for drug dependence...
- Oxidative stress and schizophrenia: combination of cell biology and brain imagingAkira Sawa; Fiscal Year: 2013..One major limitation that has blocked the progress, although mental disorders affect the brains, is the difficulty in accessing neuronal cells from patients...
- Anxiety Sensitivity, Menstrual Cycle Phase, and Panic-Relevant RespondingYael Nillni; Fiscal Year: 2011..in women is relevant to the National Institute of Mental Health's mission to reduce the burden of mental disorders through behavioral research and to the NIMH's vision to transform the prevention of mental disorders, ..
- From Defective Microglia to Cortical Activity and Pathological BehaviorMario R Capecchi; Fiscal Year: 2013..been implicated in immune dysfunction and/or signaling, contribute to increased risk to the above-mentioned mental disorders. However the basis for the above associations is not clear, which is cause or effect? Do the drugs prescribed ..
- Preventive Web-Based Intervention for Spouses of Traumatized Military PersonnelBENTSON H contact MCFARLAND; Fiscal Year: 2010..of Mental Health Special Emphasis Panel ZMH1 ERB-N (02) (Prevention of Trauma Related Adjustment and Mental Disorders in High-Risk Occupations)...
- NORADRENERGIC SYSTEM IN DEPRESSIONGREGORY ALLEN ORDWAY; Fiscal Year: 2012..Understanding the molecular pathology of this disorder holds the promise of identifying new biological targets for the development of improved treatments. ..
- Metrics and tools for phenotyping sociality and development in animal modelsJeffrey C Schank; Fiscal Year: 2011..of behavior and sociality is critical in developing and using animal models for human behavioral and mental disorders. The behavioral protocols and tools we develop will facilitate the creation of behavioral-disorder animal ..
- Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that ConHilary P Blumberg; Fiscal Year: 2010..Challenge Area (03) Biomarker Discovery and Validation and specific Challenge topic, 03-MH-101: Biomarkers in Mental Disorders and is entitled: Biomarkers of Suicide Risk in Adolescents and Young Adults: Factors that Contribute to High ..
- Sex steroids and cognition: the marmoset as a new primate modelAGNES LACREUSE; Fiscal Year: 2012..across the lifespan influence brain function and cognition and may increase vulnerability to sex-specific mental disorders and age-related decline later in life...
- Amygdala CRH, Insomnia and DepressionRong Zhang; Fiscal Year: 2012..and lead us to find a potential preventive or therapeutic approach to treat insomnia, thus, alleviate mental disorders. This Career Development Award (K01) will provide the candidate with the necessary skills to develop an ..
- Perturbed cell signaling network and suicide neurobiologyYogesh Dwivedi; Fiscal Year: 2013....
- RAPID NEURAL DIFFERENTIATION OF HUMAN STEM CELLS: A NOVEL DRUG DISCOVERY PLATFORMMARIA INES MORANO; Fiscal Year: 2010A current major challenge in pharmaceutical industry is to develop treatments for brain diseases and mental disorders such as depression, anxiety, schizophrenia, epilepsy, addiction and many more...
- Empirical eating disorder classification and validation using prospective studiesNadia Micali; Fiscal Year: 2013..1-1% have anorexia nervosa and 1-3% have bulimia nervosa. Although the Diagnostic and Statistical Manual for Mental Disorders-IV (DSM-IV) criteria are widely used to classify individuals, the eating disorder diagnoses were not ..
- Calcium Sensing Proteins in DepressionYogesh Dwivedi; Fiscal Year: 2013..These changes were quite specific as either opposite or no changes were found in other mental disorders, i.e., bipolar disorder (BPD) or schizophrenia (SCHIZ)...
- Neuronal Mechanisms for Fear Memory Generalization in PTSD and Anxiety DisordersWei Xu; Fiscal Year: 2013..Dr. Sudhof is a leading neurobiologist in studying synaptic functions and related mental disorders;Dr. Gotlib, a world renowned cognitive scientist with expertise in anxiety and depression research...
- Steroid Catecholamine Interactions and BehaviorGregory F Ball; Fiscal Year: 2013..studies can produce general principles that will facilitate insights into the etiology and pathophysiology of mental disorders. This endeavor is a major goal of the NIMH and of this research program...
- Comprehensive vs. Assisted Management of Mood and Pain Symptoms (CAMMPS) TrialKurt Kroenke; Fiscal Year: 2013..common presenting somatic symptom in medical outpatients, and depression and anxiety are the two most common mental disorders. All three conditions are often inadequately treated and result in substantial disability, reduced health-..
- EVOLUTION OF PSYCHOPATHOLOGY IN THE POPULATIONWilliam W Eaton; Fiscal Year: 2013The revision includes new details on hypotheses, severe mental disorders, race/ethnicity, attrition, and schedule...
- Neuroimaging and Behavioral Biomarkers for ADHD in ChildrenMartin H Teicher; Fiscal Year: 2010..Area 03: Biomarker Discovery and Validation, and the specific Challenge Topic 03-MH-101: Biomarkers in Mental Disorders. Attention-deficit/hyperactivity disorder (ADHD) is the most prevalent behavioral disorder of childhood ..
- The MicroRNA Pathway in Translational Regulation of Neuronal DevelopmentFen Biao Gao; Fiscal Year: 2013Several mental disorders are closely associated with defects during neuronal development in early life...
- Best Practices in Mental Health Research Ethics Conference SeriesJames M DuBois; Fiscal Year: 2010..Relevance Mental health research is necessary in order to discover the causes of and effective treatments for mental disorders, but this research must be conducted in an ethical manner...
- Regulation of Synaptic Transmission by GqMichael Ailion; Fiscal Year: 2013..Defects in neuromodulatory pathways do not usually lead to death, but can cause mental disorders such as autism, depression, schizophrenia, and attention deficit and hyperactivity disorder, as well as ..
- Novel tools for identifying GPCR compounds modulating specific sub-cellular ERK aHaifeng Eishingdrelo; Fiscal Year: 2013..modulating pathway-specific ERK activation should facilitate new GPCR drug discovery efforts for treating mental disorders. We propose four aims for the project. Aim 1. Develop G-protein-dependent ERK2 activation pathway assay...
- Treatment of Smoking Among Individuals with PTSDEdna B Foa; Fiscal Year: 2012..In fact, the quit rate for smokers with PTSD is among the lowest compared to other mental disorders. Factors that may contribute to smokers'progression to nicotine dependence and relapse include negative ..
- Role of microRNAs in skeletal developmentTatsuya Kobayashi; Fiscal Year: 2013..Defects in miRNA-dependent gene regulation have been implicated in human diseases such as cancer and mental disorders. However, knowledge about functions of miRNAs in the mammalian skeletal system is limited...
- Functional and Structural Neuroanatomy in Late-Life Generalized Anxiety DisorderCarmen Andreescu; Fiscal Year: 2013..prevalent anxiety disorder in the elderly, but it remains one of the most underdiagnosed and less studied mental disorders. It is well known that the aging brain experiences neuroanatomical change, and it has been observed that the ..
- Effect of Atypical Antipsychotics on Fructose Metabolism and Weight GainCAROLINE PALAVICINO-MAGGIO; Fiscal Year: 2012..Additionally, the mortality risk of patients suffering from mental disorders is much higher than the general population and 60% of these deaths are due to the chronic health problems ..
- Biomarkers of Interoceptive Awareness in Adolescent Anorexia NervosaNANCY L contact ZUCKER; Fiscal Year: 2010..by applicant): (03) Biomarker Discovery and Validation general challenge Area and the 03-MH-101 Biomarkers in mental disorders specific challenge topic. Anorexia nervosa (AN) is a terrifying and perplexing disorder...
- Mapping the Inputs onto Neocortical Chandelier CellsJason M Tucciarone; Fiscal Year: 2013..My proposal aims will provide the first set of data on inputs to ChCs and can be applied to mouse models of mental disorders. As such, my proposal will attempt to label the local presynaptic inputs to layer 2 (L2) and L5 ChCs in the ..
- DEVELOPING PET AGENTS FOR IMAGING PHOSPHODIESTERASE 10A (PDE10A)Zhude Tu; Fiscal Year: 2012..contribute substantially to the pathophysiology of schizophrenia, Huntington's disease (HD) and other mental disorders. Decreased striatal PDE10A level has been correlated with the severity of HD, while inhibition of PDE10A has ..
- Metabolic Screening: Prioritizing Implementation Strategies for Mental HealthElaine H Morrato; Fiscal Year: 2013..that are barriers to the implementation of recommended diabetes and dyslipidemia screening for adults with mental disorders in order to identify the best intervention strategies...
- Epigenetic Alterations of the Developing Brain in Animal Models of SchizophreniaJoseph R Ecker; Fiscal Year: 2013..affect neurodevelopment and thus may underlie the origins of the schizophrenia syndrome and possibly other mental disorders. We will test this hypothesis during postnatal development of frontal cortex of mice subjected to two ..
- AUTOMATED METHODS TO SUPPORT THE DETECTION OF DEPRESSION IN DEMENTIAHOWARD D contact WACTLAR; Fiscal Year: 2010..Area (01): Behavior, Behavioral Change, and Prevention, and specific Challenge Topic 03-MH-101: Biomarkers in Mental Disorders. Clinically significant depressive symptoms have been reported in up to 86% of nursing home residents [..
- GABAA Receptor-Interacting ProteinsAngel L De Blas; Fiscal Year: 2013..affect GABAergic synaptic function and brain development, leading to epilepsy and other neurological and mental disorders. PUBLIC HEALTH RELEVANCE: GABA is the main inhibitory neurotransmitter in the brain...
- Tobacco Craving in Smokers with SchizophreniaHeidi J Wehring; Fiscal Year: 2013..within the NIDA 5-Year Strategic Plan regarding substance abuse and treatment in persons with co-occurring mental disorders, and is consistent with the NIH mission to foster discoveries, innovative research strategies, and their ..
- Iwankapiya_Healing Historical Trauma Practice and Group IPT for American IndiansMaria Yellow Horse Brave Heart; Fiscal Year: 2013..an EBT, Group Interpersonal Psychotherapy (IPT), that may be well suited for treating depression and related mental disorders in this population...
- Medicare Part D Cost-Sharing and Treatment of Mental Disorders Among Disabled DuaJulie Marie Donohue; Fiscal Year: 2010..Medicare Part D cost-sharing policy on treatment patterns and costs for dually eligible beneficiaries with mental disorders. The objectives of this study are to examine the impact of the increased co-payments on (1) prescription drug ..
- Using fMRI to Measure Negative Symptoms in SchizophreniaEDWARD E contact SMITH; Fiscal Year: 2010..Area 03: Biomarker Discrimination and Validation, and the specific challenge topic: 03-MG-101, Biomarkers of mental disorders. Schizophrenia, a devastating psychiatric disorder, is chiefly characterized by positive symptoms, such as ..
- Social Cognition and Functioning in Bipolar DisorderMichael F Green; Fiscal Year: 2010..challenge area "03: Biomarker discovery and validation" with the specific topic "03-MH-101: Biomarkers in mental disorders." It will lead to the hiring or retention of three fulltime staff members...
- Hurricane Katrina Community Advisory GroupRonald C Kessler; Fiscal Year: 2010..the enormous devastation and slow pace of reconstruction after Katrina are likely to lead to delayed-onset mental disorders and slower recovery than in more typical disasters, making it important for needs assessment tracking to be ..
- TWO TYPES OF MONOAMINE OXIDASEJean Shih; Fiscal Year: 2007..Abnormal levels of MAO activity have[unreadable] been associated with a number of mental disorders. A better understanding[unreadable] of these isoenzymes will allow for the development of more effective[..
- Development of Amygdala specific monoclonal AntibodiesAndreas Kottmann; Fiscal Year: 2002..structures, which consolidate and express emotions and has been implicated in the pathogenesis of affective mental disorders including depression...
- Genetic markers of white matter integrity in schizophrenia: Relationship to cliniVince D Calhoun; Fiscal Year: 2010..Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic 03-MH-101* Biomarkers in Mental Disorders. Specifically, we plan to use a combination of genetic and neuroimaging tools to identify novel biomarkers of ..
- MENTAL HEALTH AND NURSE STAFFING IN US NURSING HOMESSarah Myers; Fiscal Year: 2003Using 1998 data, we have estimated persons with mental disorders in U.S. nursing homes may now total approximately 1,000,000, or 67% of all residents...
- Glucocorticoid mechanisms of neonatal separation effects on adult learningAaron A Wilber; Fiscal Year: 2009..will support the scientific integration of brain and behavior, to provide a foundation for understanding mental disorders, and will also define environmental risk for mental disorders...
- Biomarkers for Outcomes In Late-life Depression (BOLD)Ian A Cook; Fiscal Year: 2010..Challenge Area (03) Biomarker Discovery and Validation, and specific Challenge Topic 03-MH-101: Biomarkers in mental disorders, in Project BOLD (Biomarkers for Outcomes In Late-life Depression)...
- Amphetamine Acts as a Molecular Stent in the Dopamine TransporterLouis J De Felice; Fiscal Year: 2010..Area (15) Translational Science and specific Challenge Topic, 15-MH-107: Targets for Drug Discovery for Mental Disorders. Amphetamine acts as a Molecular Stent in the Dopamine Transporter By introducing the term 'molecular ..
- Discrimination, Parenting, & Resilience in Black YouthMIA S BYNUM; Fiscal Year: 2010..the challenges presented by racial discrimination and how those processes lead to the presence or absence of mental disorders is poorly understood...
- BORNA VIRUS--AN EMERGING NEUROTROPIC PATHOGEN IN HUMANSJUAN DE LA TORRE; Fiscal Year: 2000..indicates that persistent viral infections of the central nervous system (CNS) can contribute to human mental disorders of unknown etiology...
- Acute Impact of Antipsychotics on Insulin Sensitivity: A Novel Human ModelJonathan Meyer; Fiscal Year: 2009..is related to the antipsychotic medications widely used for the treatment of schizophrenia and other major mental disorders, with ample data showing that antipsychotic exposure may be associated with insulin resistance and the ..
- Parsing the schizophrenia-bipolar spectrum: an MEG based schizoaffective endophenMartin Reite; Fiscal Year: 2010..Challenge Area 03: Biomarker Discovery and Validation and specific Challenge Topic, 03-MH-101 "Biomarkers in mental disorders." The proposal is designed to develop a biomarker and physiological endophenotype for schizoaffective ..
- Trait Fear and Disinhibition in Impulse Control DisordersCHRISTOPHER JOHN PATRICK; Fiscal Year: 2010..Challenge Area (03) Biomarker Discovery and Validation and specific Challenge Topic, 03-MH-101: Biomarkers in Mental Disorders. The application takes a construct-oriented approach to the identification of biomarkers for prevalent forms ..
- CONTINUITY OF CARE & OUTCOME OF SEVERE MENTAL DISORDERSRamin Mojtabai; Fiscal Year: 2003..the principal investigator a career in mental health services research with a focus on patients with severe mental disorders. The candidate's long-term research goal is to apply the rigorous methods and analytic tools of epidemiology ..