schizophrenic psychology

Summary

Summary: Study of mental processes and behavior of schizophrenics.

Top Publications

  1. ncbi Aberrant "default mode" functional connectivity in schizophrenia
    Abigail G Garrity
    Trinity College, Hartford, CT, USA
    Am J Psychiatry 164:450-7. 2007
  2. ncbi Recent advances in the phencyclidine model of schizophrenia
    D C Javitt
    Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, N Y
    Am J Psychiatry 148:1301-8. 1991
  3. ncbi Remission in schizophrenia: proposed criteria and rationale for consensus
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
    Am J Psychiatry 162:441-9. 2005
  4. ncbi Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia
    Shitij Kapur
    Clarke Division of the Centre for Addiction and Mental Health, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 160:13-23. 2003
  5. ncbi Neurocognitive deficit in schizophrenia: a quantitative review of the evidence
    R W Heinrichs
    Department of Psychology, York University, Toronto, Ontario, Canada
    Neuropsychology 12:426-45. 1998
  6. pmc Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia
    Susan Whitfield-Gabrieli
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:1279-84. 2009
  7. pmc Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies
    Alex S Cohen
    Department of Psychology, Louisiana State University, 206 Audubon Hall Baton Rouge, LA 708080, USA
    Schizophr Bull 36:143-50. 2010
  8. pmc A meta-analysis of cognitive remediation in schizophrenia
    Susan R McGurk
    Dartmouth Psychiatric Research Center, 105 Pleasant Street, Concord, NH 03301, USA
    Am J Psychiatry 164:1791-802. 2007
  9. ncbi Mismatch negativity in schizophrenia: a meta-analysis
    Daniel Umbricht
    University of Zurich, Department of Psychiatric Research, Psychiatric University Hospital Zurich, Switzerland
    Schizophr Res 76:1-23. 2005
  10. ncbi Schizophrenia
    Kim T Mueser
    New Hampshire Dartmouth Psychiatric Research Center, Department of Psychiatry, Dartmouth
    Lancet 363:2063-72. 2004

Research Grants

  1. Recovery in Schizophrenia: Longitudinal Course
    Martin Harrow; Fiscal Year: 2007
  2. Compensating for Cognitive Deficits in Schizophrenia
    Dawn Velligan; Fiscal Year: 2005
  3. Assessing social-cognitive deficits in schizophrenia.
    Shaun Eack; Fiscal Year: 2008
  4. Motivating Persons with Schizophrenia to Exercise
    LORA BEEBE; Fiscal Year: 2008
  5. Course of Functional Deficits in Late-Life Schizophrenia
    Philip Harvey; Fiscal Year: 2007
  6. EARLY VISUAL PROCESSING IN SCHIZOPHRENIA
    Michael F Green; Fiscal Year: 2010
  7. Clinical Ratings of Neurocognition (CRON)
    Joseph Ventura; Fiscal Year: 2007
  8. Stress Reactivity & Protective Factors in Schizophrenia
    Joseph Ventura; Fiscal Year: 2003
  9. LANGUAGE PROCESSING IN SCHIZOPHRENIA
    Gina Kuperberg; Fiscal Year: 2005
  10. Effectiveness Trial of Attention Shaping for Schizophrenia
    Steven M Silverstein; Fiscal Year: 2010

Detail Information

Publications328 found, 100 shown here

  1. ncbi Aberrant "default mode" functional connectivity in schizophrenia
    Abigail G Garrity
    Trinity College, Hartford, CT, USA
    Am J Psychiatry 164:450-7. 2007
    ..It was hypothesized that the default mode network would show abnormal activation and connectivity in patients with schizophrenia...
  2. ncbi Recent advances in the phencyclidine model of schizophrenia
    D C Javitt
    Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, N Y
    Am J Psychiatry 148:1301-8. 1991
    ..The purpose of the present paper is to review recent advances in the study of the molecular mechanisms of PCP action and to describe their implications for the understanding of schizophrenic pathophysiology...
  3. ncbi Remission in schizophrenia: proposed criteria and rationale for consensus
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
    Am J Psychiatry 162:441-9. 2005
    ..These criteria should facilitate research and support a positive, longer-term approach to studying outcome in patients with schizophrenia...
  4. ncbi Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia
    Shitij Kapur
    Clarke Division of the Centre for Addiction and Mental Health, 250 College St, Toronto, Ont M5T 1R8, Canada
    Am J Psychiatry 160:13-23. 2003
    ..The objective of this overview is to link the neurobiology (brain), the phenomenological experience (mind), and pharmacological aspects of psychosis-in-schizophrenia into a unitary framework...
  5. ncbi Neurocognitive deficit in schizophrenia: a quantitative review of the evidence
    R W Heinrichs
    Department of Psychology, York University, Toronto, Ontario, Canada
    Neuropsychology 12:426-45. 1998
    ..The results indicate that schizophrenia is characterized by a broadly based cognitive impairment, with varying degrees of deficit in all ability domains measured by standard clinical tests...
  6. pmc Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia
    Susan Whitfield-Gabrieli
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:1279-84. 2009
    ..Hyperactivation (reduced task-related suppression) of default regions and hyperconnectivity of the default network may contribute to disturbances of thought in schizophrenia and risk for the illness...
  7. pmc Emotional experience in patients with schizophrenia revisited: meta-analysis of laboratory studies
    Alex S Cohen
    Department of Psychology, Louisiana State University, 206 Audubon Hall Baton Rouge, LA 708080, USA
    Schizophr Bull 36:143-50. 2010
    ..Patients' ability to experience hedonic emotion is preserved, although they also show relatively strong, simultaneously occurring aversive emotion when processing laboratory stimuli considered by others to be pleasant or neutral...
  8. pmc A meta-analysis of cognitive remediation in schizophrenia
    Susan R McGurk
    Dartmouth Psychiatric Research Center, 105 Pleasant Street, Concord, NH 03301, USA
    Am J Psychiatry 164:1791-802. 2007
    ..This study evaluated the effects of cognitive remediation for improving cognitive performance, symptoms, and psychosocial functioning in schizophrenia...
  9. ncbi Mismatch negativity in schizophrenia: a meta-analysis
    Daniel Umbricht
    University of Zurich, Department of Psychiatric Research, Psychiatric University Hospital Zurich, Switzerland
    Schizophr Res 76:1-23. 2005
    ..Many studies have reported abnormalities in the generation of MMN in schizophrenia. The objective of this study was to assess the magnitude of this deficit and associated factors...
  10. ncbi Schizophrenia
    Kim T Mueser
    New Hampshire Dartmouth Psychiatric Research Center, Department of Psychiatry, Dartmouth
    Lancet 363:2063-72. 2004
    ....
  11. pmc The neurodevelopmental hypothesis of schizophrenia, revisited
    S Hossein Fatemi
    420 Delaware St SE, MMC 392, Minneapolis, MN 55455, USA
    Schizophr Bull 35:528-48. 2009
    ..We relate the neurodevelopmental model to a number of findings about schizophrenia. Finally, we also examine alternate explanations of the origin of schizophrenia including the neurodegenerative model...
  12. ncbi What does the PANSS mean?
    Stefan Leucht
    Klinik für Psychiatrie und Psychotherapie der TU München Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munchen, Germany
    Schizophr Res 79:231-8. 2005
    ..g. at least 20% or 50% reduction of the baseline score) are as yet unclear. We therefore compared the PANSS with simultaneous ratings of Clinical Global Impressions (CGI)...
  13. ncbi Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia
    Paul C Fletcher
    University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Nat Rev Neurosci 10:48-58. 2009
    ..We suggest that it is possible to understand these symptoms in terms of a disturbed hierarchical Bayesian framework, without recourse to separate considerations of experience and belief...
  14. pmc Anhedonia and emotional experience in schizophrenia: neural and behavioral indicators
    Erin C Dowd
    Department of Neuroscience Program, Washington University, St Louis, Missouri 631320, USA
    Biol Psychiatry 67:902-11. 2010
    ..Investigation of neural activity during emotional experience may help clarify whether symptoms of anhedonia more likely reflect alterations of in-the-moment hedonic experience or impairments in other aspects of goal-directed behavior...
  15. ncbi Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review
    Max Marshall
    Division of Psychiatry, University of Manchester, Manchester
    Arch Gen Psychiatry 62:975-83. 2005
    ..It has been postulated that a longer DUP leads to a poorer prognosis. If so, outcome might be improved through earlier detection and treatment...
  16. ncbi Duration mismatch negativity in biological relatives of patients with schizophrenia spectrum disorders
    Patricia T Michie
    Centre for Clinical Research in Neuropsychiatry, University of Western Australia, Nedlands, Australia
    Biol Psychiatry 52:749-58. 2002
    ..The aim of this study was to determine whether first-degree relatives of schizophrenia patients show a similar reduction in MMN amplitude to duration deviants...
  17. ncbi Mismatch negativity in chronic schizophrenia and first-episode schizophrenia
    Dean F Salisbury
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, MA, USA
    Arch Gen Psychiatry 59:686-94. 2002
    ..The MMN is reported to be reduced in patients with chronic schizophrenia. However, it is unknown whether MMN is reduced in patients with first-episode schizophrenia (at first hospitalization)...
  18. ncbi The neurodevelopmental model of schizophrenia: update 2005
    J L Rapoport
    Child Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892 1600, USA
    Mol Psychiatry 10:434-49. 2005
    ....
  19. pmc Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group
    Carmen Simonsen
    Department of Psychology, University of Oslo, 0317 Oslo, Norway
    Schizophr Bull 37:73-83. 2011
    ..We asked whether neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends more on history of psychosis than diagnostic category or subtype...
  20. ncbi The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity
    Keith H Nuechterlein
    Department of Psychology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Rm 2251, Los Angeles, CA 90095 6968, USA
    Am J Psychiatry 165:203-13. 2008
    ....
  21. ncbi The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3270, Durham, NC 27710, USA
    Schizophr Res 68:283-97. 2004
    ..76) and healthy controls (r=0.90). These psychometric properties make the BACS a promising tool for assessing cognition repeatedly in patients with schizophrenia, especially in clinical trials of cognitive enhancement...
  22. pmc Facial emotion perception in schizophrenia: a meta-analytic review
    Christian G Kohler
    Schizophrenia Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Bull 36:1009-19. 2010
    ..0 (Borenstein M, Hedges L, Higgins J and Rothstein H. Comprehensive Meta-analysis. 2. Englewood, NJ: Biostat; 2005)...
  23. pmc The functional significance of social cognition in schizophrenia: a review
    Shannon M Couture
    Department of Psychology, University of North Carolina at Chapel Hill, CB 3270, Davie Hall, Chapel Hill, NC 27599 3270, USA
    Schizophr Bull 32:S44-63. 2006
    ..These findings are discussed in light of treatment implications for schizophrenia...
  24. ncbi Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder
    D Robinson
    Department of Psychiatry, Hillside Hospital, Long Island Jewish Medical Center, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 56:241-7. 1999
    ..We examined relapse after response to a first episode of schizophrenia or schizoaffective disorder...
  25. pmc Goal representations and motivational drive in schizophrenia: the role of prefrontal-striatal interactions
    Deanna M Barch
    Department of Psychology, Washington University, Box 1125, One Brookings Drive, St Louis, MO, USA
    Schizophr Bull 36:919-34. 2010
    ....
  26. pmc Toward the next generation of negative symptom assessments: the collaboration to advance negative symptom assessment in schizophrenia
    Jack J Blanchard
    Department of Psychology, University of Maryland, College Park, MD 20742 4411, USA
    Schizophr Bull 37:291-9. 2011
    ..The CAINS is being developed within a data-driven iterative process that seeks to ensure the measure's reliability, validity, and utility for both basic psychopathology and treatment development research...
  27. ncbi Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?
    Terry E Goldberg
    Zucker Hillside Hospital, 7559 263rd Street, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 64:1115-22. 2007
    ..However, none of these studies included healthy controls undergoing repeated testing to assess the possibility that improvements might reflect simple practice effects...
  28. ncbi Evidence for sensory prediction deficits in schizophrenia
    Sukhwinder S Shergill
    Institute of Neurology, University College London
    Am J Psychiatry 162:2384-6. 2005
    ..The authors test the hypothesis that patients with schizophrenia have defects in their ability to predict the sensory consequences of their actions...
  29. ncbi Comparison of patient and clinician perspectives in the assessment of antipsychotic medication adherence
    Corrado Barbui
    Section of Psychiatry and Clinical Psychology, Department of Medicine and Public Health, University of Verona, Verona, Italy
    Psychopathology 42:311-7. 2009
    ..Factors influencing patient and clinician perspectives in the assessment of medication adherence have never been compared...
  30. pmc Thinking about the future cognitive remediation therapy--what works and could we do better?
    Til Wykes
    Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Schizophr Bull 37:S80-90. 2011
    ....
  31. ncbi Intranasal oxytocin reduces psychotic symptoms and improves Theory of Mind and social perception in schizophrenia
    Cort A Pedersen
    Department of Psychiatry CB 7160, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
    Schizophr Res 132:50-3. 2011
    ..Our results suggest that, in addition to reducing classic psychotic symptoms, oxytocin may diminish certain social cognition deficits that are not improved by current antipsychotic medications...
  32. ncbi Mismatch negativity in schizophrenia: a family study
    Elvira Bramon
    Institute of Psychiatry, PO Box 63, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Schizophr Res 67:1-10. 2004
    ..We investigated whether MMN is a potential marker of genetic vulnerability to schizophrenia by comparing MMN in a group of patients with schizophrenia, their unaffected relatives, and controls...
  33. ncbi Memory impairment in schizophrenia: a meta-analysis
    A Aleman
    Psychological Laboratory, Utrecht University, The Netherlands
    Am J Psychiatry 156:1358-66. 1999
    ..In this article, the authors presented meta-analyses of the published literature on recall and recognition memory performance between patients with schizophrenia and normal comparison subjects...
  34. ncbi Connecting neurosis and psychosis: the direct influence of emotion on delusions and hallucinations
    Daniel Freeman
    Department of Psychology, Institute of Psychiatry, King s College London, University of London, Denmark Hill, London SE5 8AF, UK
    Behav Res Ther 41:923-47. 2003
    ..It is concluded that study needs to be made of the interaction between psychotic and neurotic processes in the development of delusions and hallucinations, and that neurotic and psychotic disorders may have common maintenance processes...
  35. ncbi Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia
    Dwight Dickinson
    VISN 5 Mental Illness Research, Education and Clinical Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arch Gen Psychiatry 64:532-42. 2007
    ..In focusing on potentially localizable cognitive impairments, the schizophrenia meta-analytic literature has overlooked the largest single impairment: on digit symbol coding tasks...
  36. pmc Schizophrenia and violence: systematic review and meta-analysis
    Seena Fazel
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    PLoS Med 6:e1000120. 2009
    ..In addition, we conducted a systematic review of investigations that reported on risk of homicide in individuals with schizophrenia and other psychoses...
  37. ncbi Impaired visual object recognition and dorsal/ventral stream interaction in schizophrenia
    Glen M Doniger
    Cognitive Neurophysiology Laboratory, Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 59:1011-20. 2002
    ..This study assessed the neural integrity of perceptual closure processes in schizophrenia by examining N(cl) generation. Generation of the preceding positive (P1) and negative (N1) ERP components was also examined...
  38. ncbi Reasoning, emotions, and delusional conviction in psychosis
    Philippa A Garety
    Department of Psychology, Institute of Psychiatry, King s College London, London, England
    J Abnorm Psychol 114:373-84. 2005
    ..Emotional states were not associated with the reasoning processes investigated. Anxiety, but not depression, made an independent contribution to delusional conviction...
  39. ncbi Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down
    Joseph H Callicott
    Clinical Brain Disorders Branch, NIMH NIH, Bldg 10, Rm 4D 20, MSC 1389, Bethesda, MD 20892 1389, USA
    Am J Psychiatry 160:2209-15. 2003
    ..The authors' goal was to explore this phenomenon...
  40. ncbi Schizophrenia, consciousness, and the self
    Louis A Sass
    Department of Clinical Psychology, Center for Cognitive Science, Rutgers University, Piscataway, NJ, USA
    Schizophr Bull 29:427-44. 2003
    ..We conclude by discussing the possible relevance of this approach for identifying early schizophrenic symptoms...
  41. ncbi Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia
    D Umbricht
    Psychiatric University Hospital, Department of Research, PO Box 68, Zurich 8029, Switzerland
    Arch Gen Psychiatry 57:1139-47. 2000
    ....
  42. pmc Examining a cognitive model of persecutory ideation in the daily life of people with schizophrenia: a computerized experience sampling study
    Dror Ben-Zeev
    Illinois Institute of Technology, Chicago, IL 60616, USA
    Schizophr Bull 37:1248-56. 2011
    ....
  43. ncbi The lifetime risk of suicide in schizophrenia: a reexamination
    Brian A Palmer
    Mayo Medical School, Department of Health Sciences Research, Rochester, Minn, USA
    Arch Gen Psychiatry 62:247-53. 2005
    ..The psychiatry literature routinely quotes a lifetime schizophrenia suicide prevalence of 10% based on 1 meta-analysis and 2 studies of chronic schizophrenics...
  44. pmc Static and dynamic cognitive deficits in childhood preceding adult schizophrenia: a 30-year study
    Abraham Reichenberg
    Department of Psychology, Duke University, Durham, NC 27708, USA
    Am J Psychiatry 167:160-9. 2010
    ..about premorbid cognitive deficits: What is their developmental course? Do all premorbid cognitive deficits follow the same course? Are premorbid cognitive deficits specific to schizophrenia or shared by other psychiatric disorders?..
  45. ncbi Stability of mismatch negativity deficits and their relationship to functional impairments in chronic schizophrenia
    Gregory A Light
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Am J Psychiatry 162:1741-3. 2005
    ....
  46. ncbi Theory of mind in schizophrenia: meta-analysis
    Mirjam Sprong
    Department of Child and Adolescent Psychiatry, University Medical Centre, Heidelberglaan 100, HPA01 468, 3508 GA Utrecht, The Netherlands
    Br J Psychiatry 191:5-13. 2007
    ..Mentalising impairment (an impaired ability to think about people in terms of their mental states) has frequently been associated with schizophrenia...
  47. ncbi Social brain dysfunctions in schizophrenia: a review of neuroimaging studies
    Eric Brunet-Gouet
    Service de Psychiatrie Adulte, Inserm ERI 0015, Hopital de Versailles, 177 route de Versailles, 78150 Le Chesnay, France
    Psychiatry Res 148:75-92. 2006
    ....
  48. pmc Major self-mutilation in the first episode of psychosis
    Matthew Large
    Schizophr Bull 35:1012-21. 2009
    ..Acute psychosis, in particular first-episode schizophrenia, appears to be the major cause of MSM. Although MSM is extremely uncommon, earlier treatment of psychotic illness may reduce the incidence of MSM...
  49. ncbi Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
    Stephen M Lawrie
    University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, UK
    Biol Psychiatry 51:1008-11. 2002
    ..We used functional magnetic resonance imaging (fMRI) to investigate the frontotemporal disconnection hypothesis of schizophrenia...
  50. ncbi Dysfunction of ventral striatal reward prediction in schizophrenia
    Georg Juckel
    Department of Psychiatry, Charite University Medical Center, Campus Charite Mitte, CCM, Schumannstr 20 21, 10117 Berlin, Germany
    Neuroimage 29:409-16. 2006
    ..We used functional magnetic resonance imaging (fMRI) to assess the BOLD response in the ventral striatum of unmedicated schizophrenics during presentation of reward-indicating and loss-indicating stimuli...
  51. ncbi The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments
    Robert W Buchanan
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Am J Psychiatry 164:1593-602. 2007
    ..Agents that act at the glycine site of the N-methyl-D-aspartic acid (NMDA) glutamatergic receptor have been suggested as promising treatments for moderate to severe negative symptoms and cognitive impairments...
  52. ncbi The five-factor model of the Positive and Negative Syndrome Scale II: a ten-fold cross-validation of a revised model
    Mark van der Gaag
    Parnassia Psychiatric Institute, Oude Haagweg 353, The Hague, The Netherlands
    Schizophr Res 85:280-7. 2006
    ..Complex means that symptoms can have multiple factor loadings, because they have multiple causes, not because they are ill defined. Stable means that the complex structure is found repeatedly in validations...
  53. ncbi Theory of mind and the role of IQ in chronic disorganized schizophrenia
    Martin Brune
    Department of Psychiatry and Psychotherapy, Ruhr University of Bochum, Alexandrinenstr 1 3, D 44791 Bochum, Germany
    Schizophr Res 60:57-64. 2003
    ..Several studies have suggested a theory of mind (ToM) deficit in schizophrenic disorders. However, the role of interfering variables such as IQ, attention, memory, and severity of the disorder has remained ambiguous...
  54. ncbi Deviant matters: duration, frequency, and intensity deviants reveal different patterns of mismatch negativity reduction in early and late schizophrenia
    Juanita Todd
    School of Psychology, University of Newcastle, Callaghan, Australia
    Biol Psychiatry 63:58-64. 2008
    ....
  55. ncbi Physiological responsivity to emotional pictures in schizophrenia
    Roelie J Hempel
    Department of Psychiatry, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Psychiatr Res 39:509-18. 2005
    ..Further studies will need to refine the dynamics of this stimulus category in relation to clinical state and medication effects...
  56. ncbi Facial emotion recognition in schizophrenia: intensity effects and error pattern
    Christian G Kohler
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Psychiatry 160:1768-74. 2003
    ..The authors used color photographs of emotional and neutral expressions to investigate recognition patterns of five universal emotions in schizophrenia...
  57. ncbi Theory of mind impairment in schizophrenia: meta-analysis
    Emre Bora
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Vic, Australia
    Schizophr Res 109:1-9. 2009
    ..Our review also suggests that future research should consider the potential moderating influence of IQ deficits on ToM performance in "remitted" patients, as well as the potential effects of residual symptoms...
  58. ncbi Facial expression and emotional face recognition in schizophrenia and depression
    W Gaebel
    Department of Psychiatry, Free University of Berlin, Federal Republic of Germany
    Eur Arch Psychiatry Clin Neurosci 242:46-52. 1992
    ..Differences in patterns of affect-related behavioral deficits may reflect dysfunctions in different underlying psychobiological systems...
  59. pmc Antipsychotic combinations vs monotherapy in schizophrenia: a meta-analysis of randomized controlled trials
    Christoph U Correll
    The Zucker Hillside Hospital, Psychiatry Research, Glen Oaks, New York, NY 11004, USA
    Schizophr Bull 35:443-57. 2009
    ..Despite lacking evidence for its safety and efficacy, antipsychotic cotreatment is common in schizophrenia...
  60. pmc Early-stage visual processing and cortical amplification deficits in schizophrenia
    Pamela D Butler
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 62:495-504. 2005
    ..Investigating magnocellular dysfunction in schizophrenia therefore permits evaluation of underlying etiologic hypotheses...
  61. pmc Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
    P R Corlett
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Brain 130:2387-400. 2007
    ..Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs...
  62. pmc Perceptual anomalies in schizophrenia: integrating phenomenology and cognitive neuroscience
    Peter J Uhlhaas
    Department of Neurophysiology, Max Planck Institute for Brain Research, Deutschordenstrasse 46, Frankfurt am Main 60528, Germany
    Schizophr Bull 33:142-56. 2007
    ..Relationships of deficits in perceptual organization to cognitive and social dysfunction as well as the possible neurobiological mechanisms are discussed...
  63. ncbi MMN/P3a deficits in first episode psychosis: comparing schizophrenia-spectrum and affective-spectrum subgroups
    Manreena Kaur
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Schizophr Res 130:203-9. 2011
    ..First-episode psychosis (FEP) patients show reduced amplitudes of the 'MMN/P3a complex', but it is unclear whether this occurs across the FEP spectrum...
  64. ncbi Obesity as a risk factor for antipsychotic noncompliance
    Peter J Weiden
    SUNY Health Sciences Center at Brooklyn, Brooklyn, NY 11203 2098, USA
    Schizophr Res 66:51-7. 2004
    ..It is, therefore, increasingly important to understand the impact of obesity and perceived weight problems on compliance with these medications...
  65. ncbi The impact of weight gain on quality of life among persons with schizophrenia
    David B Allison
    Department of Biostatistics, Section on Statistical Genetics and Clinical Nutrition Research Center, Suite 327 Ryals Public Health Building, University of Alabama at Birmingham, 1665 University Avenue, Birmingham, AL 35294, USA
    Psychiatr Serv 54:565-7. 2003
    ..Clinicians should consider the effect of weight gain on quality of life when prescribing antipsychotics and should help patients adopt weight maintenance behaviors...
  66. ncbi Neurocognition in first-episode schizophrenia: a meta-analytic review
    Raquelle I Mesholam-Gately
    Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel Deaconess Medical Center, Department of Psychiatry, Harvard Medical School, MA, USA
    Neuropsychology 23:315-36. 2009
    ..Considerable heterogeneity of effect sizes across studies, however, underscores variability in manifestations of the illness and a need for improved reporting of sample characteristics to support moderator variable analyses...
  67. pmc When top-down meets bottom-up: auditory training enhances verbal memory in schizophrenia
    R Alison Adcock
    Duke University Department of Psychiatry and Center for Cognitive Neuroscience, University of California, San Francisco, CA, USA
    Schizophr Bull 35:1132-41. 2009
    ..We conclude with the observation that neuroplasticity-based cognitive training brings patients closer to physiological patterns seen in healthy participants, suggesting that it changes the brain in an adaptive manner in schizophrenia...
  68. pmc What do we know about neuropsychological aspects of schizophrenia?
    Barton W Palmer
    University of California, San Diego, 9500 Gilman Drive 0603V, La Jolla, CA 92093 0603, USA
    Neuropsychol Rev 19:365-84. 2009
    ....
  69. pmc The 2009 schizophrenia PORT psychosocial treatment recommendations and summary statements
    Lisa B Dixon
    VA Capitol Health Care Network Mental Illness Research Education and Clinical Center, Baltimore, MD, USA
    Schizophr Bull 36:48-70. 2010
    ....
  70. ncbi An fMRI study of facial emotion processing in patients with schizophrenia
    Raquel E Gur
    Section of Neuropsychiatry, Department of Psychiatry, Gates Bldg 10th Floor, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Am J Psychiatry 159:1992-9. 2002
    ..The authors evaluated cerebral blood flow response in schizophrenia patients during facial emotion processing to test the hypothesis of diminished limbic activation related to emotional relevance of facial stimuli...
  71. ncbi Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review
    Jane Edwards
    Departments of Psychology and Psychiatry, University of Melbourne, Early Psychosis Prevention and Intervention Center, Parkville, Victoria, Australia
    Clin Psychol Rev 22:789-832. 2002
    ..Emotion recognition research in schizophrenia should be informed by the general literature on emotion recognition with serious attention paid to methodological issues...
  72. ncbi Predicting response to atypical antipsychotics based on early response in the treatment of schizophrenia
    Bruce J Kinon
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Schizophr Res 102:230-40. 2008
    ..To test whether early onset of response to antipsychotic medications accurately predicts subsequent response in the treatment of patients with schizophrenia...
  73. pmc Clinical, functional, and economic ramifications of early nonresponse to antipsychotics in the naturalistic treatment of schizophrenia
    Haya Ascher-Svanum
    Eli Lilly and Company, Indianapolis, IN 46285, USA
    Schizophr Bull 34:1163-71. 2008
    ..This study assessed the predictive accuracy of early nonresponse to treatment and its clinical, functional, and economic ramifications in the naturalistic treatment of predominately chronic outpatients treated for schizophrenia...
  74. ncbi A randomized, controlled trial of computer-assisted cognitive remediation for schizophrenia
    Dwight Dickinson
    Mental Illness Research, Education and Clinical Center, VISN 5, VA Medical Center, Suite 6A BT MIRECC, 10 North Greene St, Baltimore, MD 21201, USA
    Am J Psychiatry 167:170-80. 2010
    ..The goal of the current study was to develop a broadly targeted computer-assisted cognitive remediation program and conduct a rigorous clinical trial in a large group of schizophrenia patients...
  75. ncbi Training of affect recognition in schizophrenia: Neurobiological correlates
    Ute Habel
    University of Aachen, Aachen, Germany
    Soc Neurosci 5:92-104. 2010
    ..Specific training effects are seen to correspond with cerebral effects, probably reflecting a more efficient use of attentional, perceptual, or cognitive strategies...
  76. ncbi Clinical trial of wellness training: health promotion for severely mentally ill adults
    Linda Chafetz
    Department of Community Health Systems, University of California, San Francisco, California 94143 0608, USA
    J Nerv Ment Dis 196:475-83. 2008
    ..The WT group showed significantly better outcomes on the SF-36 physical functioning and general health scales. Findings affirm ability of SMI adults to benefit from active health promotion...
  77. ncbi A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia
    Yechiel Levkovitz
    The Emotion Cognition Research Center, The Shalvata Mental Health Care Center, P O B 94 Hod Hasharon, Israel
    J Clin Psychiatry 71:138-49. 2010
    ..Other proposed mechanisms of action include effects of minocycline on the dopaminergic system and its inhibition of microglial activation...
  78. pmc Clinical course and outcome of schizophrenia in a predominantly treatment-naive cohort in rural Ethiopia
    Atalay Alem
    Medical Faculty, Department of Psychiatry, Addis Ababa University, Addis Ababa, Ethiopia
    Schizophr Bull 35:646-54. 2009
    ..Improving access to treatment may be the logical next step to improve outcome of schizophrenia in this setting...
  79. ncbi Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?
    Sophia Vinogradov
    Department of Psychiatry, School of Medicine, University of California San Francisco, California 94121, USA
    Biol Psychiatry 66:549-53. 2009
    ..We asked: would neuroplasticity-based cognitive training in schizophrenia result in increased serum BDNF?..
  80. pmc Mouse pharmacological models of cognitive disruption relevant to schizophrenia
    Jared W Young
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA 92093 0804, USA
    Neuropharmacology 62:1381-90. 2012
    ..We conclude that the predictive validity of these models is currently difficult to assess and that much more needs to be done to develop useful mouse pharmacological models of cognitive disruption in schizophrenia...
  81. ncbi Negative symptoms and poor insight as predictors of the similarity between client and therapist ratings of therapeutic alliance in cognitive behavior therapy for patients with schizophrenia
    Paul H Lysaker
    Roudebush VA Medical Center, Indianapolis, IN, USA
    J Nerv Ment Dis 199:191-5. 2011
    ..Higher overall therapist ratings were linked only to lower levels of disorganized symptoms among clients...
  82. ncbi Mismatch negativity (MMN) reduction in schizophrenia-impaired prediction--error generation, estimation or salience?
    Juanita Todd
    School of Psychology, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    Int J Psychophysiol 83:222-31. 2012
    ..Possible interpretations of MMN studies in schizophrenia are linked to dominant theories about the neurobiology of the illness...
  83. ncbi World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, Part 1: acute treatment of schizophrenia
    Peter Falkai
    Department of Psychiatry and Psychotherapy, University of Saarland, Homburg Saar, Germany
    World J Biol Psychiatry 6:132-91. 2005
    ....
  84. ncbi Insight into illness, neurocognition and quality of life in schizophrenia
    L Boyer
    Aix Marseille Univ, EA 3279 Research Unit, 13385 Marseille, France
    Prog Neuropsychopharmacol Biol Psychiatry 36:271-6. 2012
    ..The aim of this study was to assess the impact of insight into illness on self-reported quality of life (QoL) for patients with schizophrenia...
  85. ncbi Neurocognitive effects of first- and second-generation antipsychotic drugs in early-stage schizophrenia: a naturalistic 12-month follow-up study
    Xiaofeng Guo
    Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, China
    Neurosci Lett 503:141-6. 2011
    ..Given that some neurocognitive improvement is attributable to a practice effect, any improvement is likely to be in the range of a small effect size...
  86. pmc Distinct neural generators of sensory gating in schizophrenia
    Terrance J Williams
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Psychophysiology 48:470-8. 2011
    ..In each instance, the neural structure was found to account for unique variance in explaining the P50 ratio, along with some suggestion of DLPFC involvement in healthy subjects...
  87. ncbi Possible dysregulation of cortical plasticity in auditory verbal hallucinations-A cortical thickness study in schizophrenia
    Claudia van Swam
    Dept of Psychiatric Neurophysiology, University Hospital of Psychiatry Bern, Bolligenstrasse 111, Bern, Switzerland
    J Psychiatr Res 46:1015-23. 2012
    ....
  88. ncbi The relation between objective and subjective domains of recovery among persons with schizophrenia-related disorders
    David Roe
    Department of Community Mental Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel
    Schizophr Res 131:133-8. 2011
    ..Taken together, results are consistent with literature suggesting that clinical objective recovery is not synonymous with personal subjective recovery yet can be conceptualized as complementary...
  89. ncbi Error-related processing dysfunction in children aged 9 to 12 years presenting putative antecedents of schizophrenia
    Kristin R Laurens
    Department of Forensic Mental Health Science, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    Biol Psychiatry 67:238-45. 2010
    ..This study examined whether ASz children display brain function abnormalities during error processing that are similar to those exhibited by adults with schizophrenia...
  90. ncbi Phenomenology of anomalous self-experience in early schizophrenia
    Josef Parnas
    Cognitive Research Unit, Department of Psychiatry, Hvidore Hospital, University of Copenhagen, Copenhagen, Denmark
    Compr Psychiatry 44:121-34. 2003
    ..Psychopathological emphasis on these disorders may also help to integrate the search for the neurodevelopmental mechanisms in schizophrenia with developmental-psychological research on the ontogenesis of the self...
  91. ncbi Patients with schizophrenia demonstrate dissociation between affective experience and motivated behavior
    Erin A Heerey
    Maryland Psychiatric Research Center, University of Maryland Baltimore, Baltimore, MD, USA
    J Abnorm Psychol 116:268-78. 2007
    ..These data suggest that the motivational deficits in schizophrenia reflect problems in the ability to translate experience into action...
  92. pmc Impact of neurocognition on social and role functioning in individuals at clinical high risk for psychosis
    Ricardo E Carrión
    Department of Psychiatry Research, Zucker Hillside Hospital, NorthShore Long Island Jew ish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 168:806-13. 2011
    ..The authors assessed cognitive impairment in adolescents at clinical high risk for psychosis and examined its impact on social and role functioning...
  93. ncbi Impact of obesity on health-related quality of life in schizophrenia and bipolar disorder
    Ronette L Kolotkin
    Obesity and Quality of Life Consulting, Durham, North Carolina, USA
    Obesity (Silver Spring) 16:749-54. 2008
    ..This paper explores the health-related quality of life (HRQOL) of individuals with schizophrenia or bipolar disorder as a function of obesity status...
  94. pmc Differentiation of schizophrenia patients from healthy subjects by mismatch negativity and neuropsychological tests
    Yi Ting Lin
    Department of Psychiatry, National Taiwan University Hospital Yun Lin Branch, Dou Liou City, Yun Lin, Taiwan
    PLoS ONE 7:e34454. 2012
    ....
  95. ncbi Divergent effects of two different doses of intranasal oxytocin on facial affect discrimination in schizophrenic patients with and without polydipsia
    Morris B Goldman
    Department of Psychiatry, Northwestern University, 446 East Ontario Suite 7 100, Chicago, IL 60611, USA
    Psychopharmacology (Berl) 216:101-10. 2011
    ..Intranasal oxytocin enhances facial affect discrimination in healthy subjects...
  96. ncbi Nicotine dependence in schizophrenia: clinical phenomena and laboratory findings
    G W Dalack
    Ann Arbor VA Medical Center, MI 48105, USA
    Am J Psychiatry 155:1490-501. 1998
    ..The goal of this report is to examine the potential implications of the high prevalence of smoking in schizophrenia for our understanding of this illness...
  97. ncbi Appreciating symptoms and deficits in schizophrenia: right posterior insula and poor insight
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham, NG7 2UH, United Kingdom
    Prog Neuropsychopharmacol Biol Psychiatry 35:523-7. 2011
    ..Abnormalities in interoceptive awareness and self-appraisal of emotional states may contribute to the loss of insight seen in schizophrenia...
  98. ncbi Empathic abilities in people with schizophrenia
    Emre Bora
    Melbourne Neuropsychiatry Centre, Psychiatry Department of Melbourne University, Victoria, Australia
    Psychiatry Res 160:23-9. 2008
    ..Studies focusing on dysfunctional brain networks underlying empathy deficits and studies using more experimental measures of empathy should be helpful to unravel the true nature of the empathic failure in patients with schizophrenia...
  99. ncbi Social cognition, empathy and functional outcome in schizophrenia
    Amy Sparks
    School of Psychiatry, University of New South Wales, Sydney NSW 2031, Australia
    Schizophr Res 122:172-8. 2010
    ..These findings have implications for the remediation of specific social cognitive deficits with respect to improving functional outcomes in schizophrenia...
  100. ncbi The amphetamine-induced sensitized state as a model of schizophrenia
    R E Featherstone
    Section of Biopsychology, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Prog Neuropsychopharmacol Biol Psychiatry 31:1556-71. 2007
    ..It is concluded that amphetamine sensitization likely impacts behaviour by altering the functioning of mesolimbic dopamine systems and prefrontal cortical function and can serve as a model of certain domains of schizophrenia...
  101. ncbi Reducing prefrontal gamma-aminobutyric acid activity induces cognitive, behavioral, and dopaminergic abnormalities that resemble schizophrenia
    Takeshi Enomoto
    Department of Psychology and Brain Research Centre, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada
    Biol Psychiatry 69:432-41. 2011
    ..However, a preclinical assessment of how suppression of prefrontal cortex GABA activity may reflect behavioral and cognitive pathologies observed in schizophrenia is forthcoming...

Research Grants70

  1. Recovery in Schizophrenia: Longitudinal Course
    Martin Harrow; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  2. Compensating for Cognitive Deficits in Schizophrenia
    Dawn Velligan; Fiscal Year: 2005
    ..abstract_text> ..
  3. Assessing social-cognitive deficits in schizophrenia.
    Shaun Eack; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  4. Motivating Persons with Schizophrenia to Exercise
    LORA BEEBE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  5. Course of Functional Deficits in Late-Life Schizophrenia
    Philip Harvey; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  6. EARLY VISUAL PROCESSING IN SCHIZOPHRENIA
    Michael F Green; Fiscal Year: 2010
    ....
  7. Clinical Ratings of Neurocognition (CRON)
    Joseph Ventura; Fiscal Year: 2007
    ..The proposed developments are urgently needed to continue the momentum established by the MATRICS initiative, and facilitate regulatory acceptance and clinical awareness of new treatments for CIAS. [unreadable] [unreadable] [unreadable]..
  8. Stress Reactivity & Protective Factors in Schizophrenia
    Joseph Ventura; Fiscal Year: 2003
    ..abstract_text> ..
  9. LANGUAGE PROCESSING IN SCHIZOPHRENIA
    Gina Kuperberg; Fiscal Year: 2005
    ..This training and research program will advance the candidate to the stage when she can establish herself as an independent investigator of the cognitive neuroscience of schizophrenia. ..
  10. Effectiveness Trial of Attention Shaping for Schizophrenia
    Steven M Silverstein; Fiscal Year: 2010
    ....
  11. Dopaminergic Mechanisms of Reward in Schizophrenia
    James Gold; Fiscal Year: 2007
    ..If successful, the proposed work is designed to establish the conceptual foundation and preliminary data needed to support individual RO1 applications and a Translational Center. [unreadable] [unreadable]..
  12. Electrophysiological Correlates of Anhedonia in Schizophrenia
    WILLIAM HORAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. Pleasant Events and Moods: A Time-Series Analysis
    Brent Mausbach; Fiscal Year: 2006
    ..The remaining participants will receive no feedback. All participants will receive a one-month follow-up to determine if those receiving detailed feedback experience fewer negative emotions and more positive emotions. ..
  14. WORK OUTCOME IN SCHIZOPHRENIA--BRAIN FUNCTION/STRUCTURE
    James Gold; Fiscal Year: 2002
    ..Abnormalities present in both good and poor outcome groups are arguably fundamental features of the illness. ..
  15. Interventions for Adherence to Oral Antipsychotic Medications in Schizophrenia
    DAWN IRENE VELLIGAN; Fiscal Year: 2010
    ..The public health implications include effective disease management, maximizing long-term outcomes, and containing health care costs for schizophrenia. ..
  16. MEDICATION ADHERENCE AND OUTCOMES IN SCHIZOPHRENIA
    Dawn Velligan; Fiscal Year: 2004
    ..Moreover, we hypothesize that compliance and functioning will return to baseline levels six months after discontinuation of treatment. ..
  17. Clozapine Treatment of Schizophrenic Patients
    Robert Buchanan; Fiscal Year: 2006
    ..The study will provide new information on the clinical utility of adjunctive risperidone in treatment-resistant patients who fail to adequately respond to clozapine. ..
  18. Advanced Centers for Interventions and Services Research
    Robert Buchanan; Fiscal Year: 2007
    ....
  19. Comorbid Substance Abuse and Long-Term Health Outcomes in Schizophrenia
    DEANNA KELLY; Fiscal Year: 2008
    ..This will be an important step for improving the lives of people with schizophrenia. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  20. Incentives Plus Bupropion for Smoking in Schizophrenics
    Jennifer Tidey; Fiscal Year: 2006
    ..This study will provide significant information regarding the efficacy and feasibility of using a combination of contingency management and smoking pharmacotherapy to treat smoking in schizophrenics. [unreadable] [unreadable]..
  21. Cardiac-Related Mortality with Atypical Antipsychotics
    DEANNA KELLY; Fiscal Year: 2005
    ..This study is important as data on long-term health outcomes with atypical antipsychotics is lacking from the literature. ..
  22. PROSPECTIVE STUDY OF TARDIVE DYSKINESIA DEVELOPMENT
    John Kane; Fiscal Year: 2001
    ..This strategy will provide a rapid and cost-effective answer to a critical question. ..
  23. Biological and Behavioral Mechanisms of Smoking in Schizophrenia
    Jennifer Tidey; Fiscal Year: 2009
    ..In turn, this information could be used to develop novel treatment strategies for these smokers. ..
  24. Cognitive Training and Enhanced Supported Employment
    Morris D Bell; Fiscal Year: 2010
    ..FU, and 2 yr. FU will focus on cognitive and vocational outcomes, but will also include clinical status, quality of life and community function measures. Predictors of response to training will also be examined. ..
  25. Cognitive Behavioral Skills Training for Schizophrenia
    Eric Granholm; Fiscal Year: 2009
    ....
  26. The Effects of the Cannabinoid-1 Receptor Antagonist Rimonabant on Weight...
    Robert Buchanan; Fiscal Year: 2008
    ..There should be direct evidence of efficacy and safety in these patients in order to provide truly effective treatments and further understanding of these disorders. [unreadable] [unreadable] [unreadable]..
  27. Innovative Training Methods for Improving Work Outcome
    Robert Kern; Fiscal Year: 2004
    ..abstract_text> ..
  28. Mapping Abnormal Neurodevelopment in Schizophrenia
    Deanna Barch; Fiscal Year: 2008
    ..unreadable] ..
  29. PUPILLARY RESPONSES AND COGNITIVE AGING IN SCHIZOPHRENIA
    Eric Granholm; Fiscal Year: 2004
    ..Abnormal age-related decline on these measures would suggest an abnormally accelerated depletion of processing resources with aging in schizophrenia in late life and would support the neurodegeneration hypothesis. ..
  30. CLOZAPINE AND OLANZAPINE IN VIOLENT SCHIZOPHRENICS
    Menahem Krakowski; Fiscal Year: 2003
    ..e. ability to utilize environmental feedback, impulsivity, and psychosis. Similar to the outcome measures, these symptoms will improve more with CLO than OLZ and more with OLZ than HAL. ..
  31. Genetics of Endophenotypes and Schizophrenia
    Larry Seidman; Fiscal Year: 2007
    ..Findings of heritable deficits in specific measures will be used to guide the next generation of studies of the genetics of schizophrenia. ..
  32. Graduated Recovery Intervention for Early Schizophrenia
    David Penn; Fiscal Year: 2007
    ..abstract_text> ..
  33. rTMS Clinical Trial for Auditory Hallucinations
    RALPH EDWARD HOFFMAN; Fiscal Year: 2010
    ..This study will provide critical information regarding positioning strategies that optimize rTMS for AHs, as well as new insights regarding underlying pathophysiology. ..
  34. Folate in Schizophrenia
    Donald C Goff; Fiscal Year: 2010
    ..This will be the first adequately-powered study to assess efficacy and identify predictors of response. ..
  35. Visual Processing in Schizophrenia
    Pamela Butler; Fiscal Year: 2008
    ..abstract_text> ..
  36. Family Study of Psychosis: Brain, Genes & Prenatal Risk
    Larry Seidman; Fiscal Year: 2005
    ..Moreover, if rigorous definitions of PPCs are used, it will be possible to identify the specific types of PPCs associated with brain abnormalities, which can lead to prevention strategies. ..
  37. METHYLPHENIDATE TREATMENT OF ADHD IN CHILDREN WITH TS
    Kenneth Gadow; Fiscal Year: 2004
    ..To evaluate the impact of tic severity and comorbid internalizing and externalizing symptoms on clinical outcome, children with ADHD/+tics will be compared with an additional sample of children with ADHD/-tics at ages 11 and 16 years. ..
  38. Neural Network Models of Language
    Ralph Hoffman; Fiscal Year: 2005
    ..These findings will significantly advance our understanding of illness mechanisms in schizophrenia and direct future research aimed at developing more selective treatments that reverse these abnormalities. ..
  39. Antidepressant Augmentation of Late Life Schizophrenia
    John Kasckow; Fiscal Year: 2005
    ....
  40. Neuroanatomy of Adult ADHD: An MRI Morphometric Study
    Larry Seidman; Fiscal Year: 2006
    ..abstract_text> ..
  41. SCHIZOPHRENIA--PSYCHOPATHOLOGY AND HETEROGENEITY
    Larry Seidman; Fiscal Year: 2004
    ..Achievement of the second goal will help clarify which brain abnormalities in schizophrenic patients can be attributed to neurodevelop-mental events prior to onset and which are due to neurodegeneration after onset. ..
  42. Identifying molecular path of behavioural phenotype in schizophrenia
    L Hong; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. Addiction and Subsequent Schizophrenia: A Link?
    Serge Sevy; Fiscal Year: 2008
    ..abstract_text> ..
  44. Quality Life Among Youth with Craniofacial Conditions
    Donald Patrick; Fiscal Year: 2004
    ..S., and one in the United Kingdom. Adolescents and their parents will complete questionnaires at baseline, and gain at 1-2 year clinical follow-up. ..
  45. Cognitive Control Deficits and Formal Thought Disorder
    JOHN KERNS; Fiscal Year: 2005
    ..abstract_text> ..
  46. DEVELOPMENTAL PROCESSES IN SCHIZOPHRENIC DISORDERS
    Keith H Nuechterlein; Fiscal Year: 2010
    ..Potential predictors of response to these treatments will be evaluated. ..
  47. PEDIATRIC BIPOLAR COLLABORATIVE MOOD STABILZER TRAIL
    Robert Findling; Fiscal Year: 2003
    ..Lastly, this trial will provide descriptive information on the stability of acute phase response to monotherapy over a 16 week continuation phase. ..
  48. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  49. Liability Markers for Deficit Schizophrenia?
    L Hong; Fiscal Year: 2004
    ..We plan to use the preliminary data collected from this grant support to guide our full-scale search for phenotypic markers specifically associated with the liability for deficit schizophrenia and subsequent molecular genetic studies. ..
  50. Safety and Efficacy of Sertraline for Depression Congestive Heart Failure
    Ranga Krishnan; Fiscal Year: 2007
    ..Information collected in these follow-up contacts will include deaths, re-hospitalizations, cardiac events, functional status/quality of life measures, and level of depressive symptoms. ..
  51. MOLECULAR GENETICS OF HEROIN DEPENDENCE
    Ming Tsuang; Fiscal Year: 2004
    ..All genotypes will be available one year after they are generated, but no later than a year after the end of the funding period. We are submitting this proposal using the RO1 mechanism. ..
  52. INTERVENTION RESEARCH TRAINING FOR THE PSYCHOSES
    Keith Nuechterlein; Fiscal Year: 2004
    ..D.s and the other half Ph.D.s. Trainees will be assigned to primary and secondary mentors who will supervise their training activities in an individualized research mentorship model. ..
  53. Frontal White Matter and Impulsivity in Schizophrenia
    Matthew Hoptman; Fiscal Year: 2007
    ..A secondary aim will examine the relationship between FA and violence. Understanding the neural basis of impulsivity in schizophrenia would help identify at-risk patients and inform new treatment approaches. ..
  54. Metabolic Effects of Newer Antipsychotics in Older Pts
    Dilip Jeste; Fiscal Year: 2009
    ..abstract_text> ..
  55. Gender, Drinking Pattens, Health & Services Seeking
    Carla Green; Fiscal Year: 2004
    ..Results from this study will advance our ability to develop gender-specific screening and intervention procedures that reduce adverse health consequences related to drinking patterns and other health behaviors. ..
  56. PARTIAL DOPAMINEAGONIST TREATMENT OF SCHIZOPHRENIA
    Carol Tamminga; Fiscal Year: 2002
    ..These data will predict and later help us to select optimal agonist intrinsic activity ior clinical testing for antipsychotic actvity, duration of therapeutic action, and side effects. ..
  57. Schizophrenia Biomarkers: Blood vs Brain Gene Expression
    Ming Tsuang; Fiscal Year: 2006
    ..abstract_text> ..
  58. Antipsychotic-Like Drug Effects of Neurotensin
    David Feifel; Fiscal Year: 2004
    ....
  59. Work Rehabilitation For Older Adults With Schizophrenia
    Elizabeth Twamley; Fiscal Year: 2007
    ..abstract_text> ..
  60. Alternate Phenotypes of Substance Abuse
    Ming Tsuang; Fiscal Year: 2006
    ..The enormous health and financial costs of illicit drug abuse, both to the individual and to society, underscores the pressing need for such research. ..
  61. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  62. Treatment Issues In Smokers with Schizophrenia
    Marc Steinberg; Fiscal Year: 2008
    ..The plan will include important hands-on learning experiences, workshops, class work, attendance at national scientific conferences, and strong mentoring relationships. ..
  63. Ensuring Informed Consent Delivery As A Process
    BARTON PALMER; Fiscal Year: 2003
    ..With this experience, we will then hold two 60 minute seminars (one at each facility) to disseminate the procedures developed for wider use by all researchers at each of the two facilities. ..
  64. Quality of Life of Overweight Youth: Multicultural View
    Donald Patrick; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  65. Ethnicity and the Diagnosis of Affective Illness
    Michael Gara; Fiscal Year: 2008
    ..The final objective is to determine whether Latinos are at risk for similar problems in diagnostic assessments and treatment assignment. ..
  66. Quality of Somatic Care for the Seriously Mentally III
    Richard Goldberg; Fiscal Year: 2005
    ..The overall goal of the educational/training program is to increase the methodological rigor of the proposed research and to facilitate the ability of the investigator to integrate these domains of research into further projects. ..
  67. Suicidal Behavior in Persons with Schizophrenia in China
    MAOSHENG RAN; Fiscal Year: 2005
    ..The results of this study will be crucial for further mental health intervention and prevention of suicide among persons with schizophrenia. ..
  68. TREATMENT OF NEGATIVE SYMPTOMS & COGNITIVE IMPAIRMENTS
    William Carpenter; Fiscal Year: 2003
    ..The study will provide new information on the efficacy of d- cyclosporine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
  69. TREATMENT DECISION MAKING CAPACITY IN SCHIZOPHRENIA
    BARTON PALMER; Fiscal Year: 2002
    ..abstract_text> ..