brief psychiatric rating scale

Summary

Summary: A scale comprising 18 symptom constructs chosen to represent relatively independent dimensions of manifest psychopathology. The initial intended use was to provide more efficient assessment of treatment response in clinical psychopharmacology research; however, the scale was readily adapted to other uses. (From Hersen, M. and Bellack, A.S., Dictionary of Behavioral Assessment Techniques, p. 87)

Top Publications

  1. ncbi Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics
    Jean A Frazier
    Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA
    J Am Acad Child Adolesc Psychiatry 46:979-88. 2007
  2. ncbi Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial
    Mitsutaka Nakamura
    Dainippon Sumitomo Pharma America Inc, Fort Lee, NJ 07024, USA
    J Clin Psychiatry 70:829-36. 2009
  3. ncbi Consistency of Brief Psychiatric Rating Scale factor structure across a broad spectrum of schizophrenia patients
    Alex Kopelowicz
    David Geffen School of Medicine at University of California, Los Angeles, CA, USA
    Psychopathology 41:77-84. 2008
  4. ncbi Brief psychiatric rating scale expanded version: How do new items affect factor structure?
    Dawn Velligan
    Department of Psychiatry, University of Texas Health Sciences Center at San Antonio, Mail Stop 7792, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Psychiatry Res 135:217-28. 2005
  5. ncbi The relative sensitivity of the Clinical Global Impressions Scale and the Brief Psychiatric Rating Scale in antipsychotic drug trials
    Stefan Leucht
    Klinik für Psychiatrie und Psychotherapie der TU München, Klinikum rechts der Isar, Germany
    Neuropsychopharmacology 31:406-12. 2006
  6. ncbi [Factor analysis and validation of a Spanish version of the Brief Psychiatric Rating Scale in Colombia]
    Ricardo Sanchez
    Facultad de Medicina, Universidad Nacional de Colombia, Ciudad Universitaria, Bogota, D C, Colombia
    Biomedica 25:120-8. 2005
  7. pmc Is there a linear relationship between the Brief Psychiatric Rating Scale and the Clinical Global Impression-Schizophrenia scale? A retrospective analysis
    Jitsuki Sawamura
    Department of Psychiatry, Tokyo Women s Medical University, Tokyo, Japan
    BMC Psychiatry 10:105. 2010
  8. pmc Relationship of dementia screening tests with biomarkers of Alzheimer's disease
    James E Galvin
    Alzheimer s Disease Research Centre, Washington University, St Louis, MO 63108, USA
    Brain 133:3290-300. 2010
  9. ncbi Factor structure of Bech's version of the Brief Psychiatric Rating Scale in Brazilian patients
    J A S Crippa
    Departamento de Neurologia, Psiquiatria e Psicologia Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 35:1209-13. 2002
  10. ncbi Remission in schizophrenia: proposed criteria and rationale for consensus
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
    Am J Psychiatry 162:441-9. 2005

Detail Information

Publications229 found, 100 shown here

  1. ncbi Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics
    Jean A Frazier
    Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA
    J Am Acad Child Adolesc Psychiatry 46:979-88. 2007
    ..We examined baseline demographic and clinical profiles of youths enrolled from 2001 to 2006 in the publicly funded multicenter, randomized controlled trial Treatment of Early-Onset Schizophrenia Spectrum Disorders...
  2. ncbi Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial
    Mitsutaka Nakamura
    Dainippon Sumitomo Pharma America Inc, Fort Lee, NJ 07024, USA
    J Clin Psychiatry 70:829-36. 2009
    ..The objective of the study was to evaluate the safety and efficacy of lurasidone in patients hospitalized for an acute exacerbation of DSM-IV-defined schizophrenia...
  3. ncbi Consistency of Brief Psychiatric Rating Scale factor structure across a broad spectrum of schizophrenia patients
    Alex Kopelowicz
    David Geffen School of Medicine at University of California, Los Angeles, CA, USA
    Psychopathology 41:77-84. 2008
    The Brief Psychiatric Rating Scale (BPRS) has been the workhorse of psychopathology assessment in studies of schizophrenia and related psychotic disorders for over 40 years...
  4. ncbi Brief psychiatric rating scale expanded version: How do new items affect factor structure?
    Dawn Velligan
    Department of Psychiatry, University of Texas Health Sciences Center at San Antonio, Mail Stop 7792, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Psychiatry Res 135:217-28. 2005
    Our goal was to suggest a factor structure for the Brief Psychiatric Rating Scale Expanded Version (BPRS-E) based upon a large and diverse sample and to determine which of the new items improved the factors derived from the 18-item ..
  5. ncbi The relative sensitivity of the Clinical Global Impressions Scale and the Brief Psychiatric Rating Scale in antipsychotic drug trials
    Stefan Leucht
    Klinik für Psychiatrie und Psychotherapie der TU München, Klinikum rechts der Isar, Germany
    Neuropsychopharmacology 31:406-12. 2006
    Although the Clinical Global Impression (CGI) and the Brief Psychiatric Rating Scale (BPRS) are both frequently used in drug trials for schizophrenia, their relative sensitivity in detecting differences between antipsychotics has not yet ..
  6. ncbi [Factor analysis and validation of a Spanish version of the Brief Psychiatric Rating Scale in Colombia]
    Ricardo Sanchez
    Facultad de Medicina, Universidad Nacional de Colombia, Ciudad Universitaria, Bogota, D C, Colombia
    Biomedica 25:120-8. 2005
    A validation study was directed toward an evaluation of the Brief Psychiatric Rating Scale (BPRS) in a Spanish-language version in Colombia...
  7. pmc Is there a linear relationship between the Brief Psychiatric Rating Scale and the Clinical Global Impression-Schizophrenia scale? A retrospective analysis
    Jitsuki Sawamura
    Department of Psychiatry, Tokyo Women s Medical University, Tokyo, Japan
    BMC Psychiatry 10:105. 2010
    Although the Brief Psychiatric Rating Scale (BPRS) is widely used for evaluating patients with schizophrenia, it has limited value in estimating the clinical weight of individual symptoms...
  8. pmc Relationship of dementia screening tests with biomarkers of Alzheimer's disease
    James E Galvin
    Alzheimer s Disease Research Centre, Washington University, St Louis, MO 63108, USA
    Brain 133:3290-300. 2010
    ....
  9. ncbi Factor structure of Bech's version of the Brief Psychiatric Rating Scale in Brazilian patients
    J A S Crippa
    Departamento de Neurologia, Psiquiatria e Psicologia Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Braz J Med Biol Res 35:1209-13. 2002
    The objective of the present study was to evaluate the factor structure of Bech's version of the Brief Psychiatric Rating Scale (BPRS), translated into Portuguese...
  10. ncbi Remission in schizophrenia: proposed criteria and rationale for consensus
    Nancy C Andreasen
    Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA
    Am J Psychiatry 162:441-9. 2005
    ..These criteria should facilitate research and support a positive, longer-term approach to studying outcome in patients with schizophrenia...
  11. ncbi Inter-rater reliability of the Brief Psychiatric Rating Scale and the Groningen Social Disabilities Schedule in a European multi-site randomized controlled trial on the effectiveness of acute psychiatric day hospitals
    Matthias Schützwohl
    Department of Psychiatry at Dresden University of Technology, Dresden, Germany
    Int J Methods Psychiatr Res 12:197-207. 2003
    The objectives of this study were to report the inter-rater reliability of the Brief Psychiatric Rating Scale (BPRS 4...
  12. ncbi Symptoms versus neurocognitive test performance as predictors of psychosocial status in schizophrenia: a 1- and 4-year prospective study
    Matthew M Kurtz
    Schizophrenia Rehabilitation Program, Neuropsychiatry Research Center, Institute of Living, 200 Retreat Avenue, Hartford, CT 06106, USA
    Schizophr Bull 31:167-74. 2005
    ..The significance of these findings for the development and assessment of novel treatment interventions for schizophrenia is discussed...
  13. pmc A real-life observational study of the effectiveness of FACT in a Dutch mental health region
    Marjan Drukker
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, PO Box 616, location Vijverdal 6200 MD Maastricht, The Netherlands
    BMC Psychiatry 8:93. 2008
    ..The effectiveness of FACT was compared with standard care, with a particular focus on possible moderating effects of patient characteristics within the case mix in FACT...
  14. ncbi Factor structure and differential validity of the expanded Brief Psychiatric Rating Scale
    Adrian Thomas
    Department of Psychology, Auburn University, AL 36849, USA
    Assessment 11:177-87. 2004
    The Brief Psychiatric Rating Scale (BPRS) is one of the most widely used measures in psychiatric outcome and clinical psychopharmacology research...
  15. ncbi Hospital comorbidity bias and the concept of schizophrenia
    Maarten Bak
    Dept of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 40:817-21. 2005
    ..The direction of any dimensional comorbidity bias in psychotic illness was assessed in a longitudinal analysis of the psychopathology of patients assessed both inside and outside the hospital...
  16. ncbi Selection of outcome assessment instruments for inpatients with severe and persistent mental illness
    Gary M Burlingame
    Brigham Young University, 238 TLRB, Provo, Utah 84602, USA
    Psychiatr Serv 56:444-51. 2005
    ..The limited resources associated with publicly funded inpatient facilities led to a recommendation to select at least one rater-completed and one patient-completed instrument...
  17. ncbi Symptom dimensions in recent-onset schizophrenia and mania: a principal components analysis of the 24-item Brief Psychiatric Rating Scale
    J Ventura
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095 6968, USA
    Psychiatry Res 97:129-35. 2000
    Previous four- and five-factor solutions of the 18-item Brief Psychiatric Rating Scale (BPRS) suggested the possibility of an affective dimension in psychosis...
  18. ncbi Stress and HPA-axis functioning in young people at ultra high risk for psychosis
    K N Thompson
    PACE Clinic Orygen Research Centre, Locked Bag 10, Parkville 3052, Australia
    J Psychiatr Res 41:561-9. 2007
    ..These results indicate possible impairment in HPA-axis functioning in the early stages of psychotic illness, but further investigation of the relationships between these parameters is required...
  19. pmc Reliability of the interRAI suite of assessment instruments: a 12-country study of an integrated health information system
    John P Hirdes
    University of Waterloo, 200 University Ave W, Waterloo, ON N2L 3G1, Canada
    BMC Health Serv Res 8:277. 2008
    ..This study examined the reliability of the items from five instruments supporting home care, long term care, mental health, palliative care and post-acute care...
  20. ncbi Predicting inpatient length of stay with the expanded version of the Brief Psychiatric Rating Scale (version 4.0)
    Shawanda W Anderson
    Clinical Psychology Department, Jackson State Universy, Jackson, Mississippi, USA
    Psychiatr Serv 55:77-9. 2004
    This study examined whether assessment data from administration of the extended version of the Brief Psychiatric Rating Scale (BPRS-E) to state hospital patients within 72 hours of their admission could be used to predict length of ..
  21. ncbi Subjective and objective measures of quality of life have different predictors for people with schizophrenia
    Masahito Tomotake
    Department of Psychiatry, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushimashi, Tokushima 770 8503, Japan
    Psychol Rep 99:477-87. 2006
    ..Psychiatric symptoms were also measured with the Brief Psychiatric Rating Scale and the Calgary Depression Scale for Schizophrenia...
  22. ncbi [Assessment of the Life Skills Profile and the Brief Psychiatric Rating Scale as predictors of the length of psychiatric hospitalization]
    J Ballesteros Rodríguez
    Fundación M feminine Josefa Recio Instituto de Investigaciones Psiquiátricas, Bilbao, Universidad del Pais Vasco, Leioa Bilbao, Spain
    Actas Esp Psiquiatr 30:225-32. 2002
    ..The aims of this study are to analyse the relationship between illness severity and adaptative behavior and to assess the predictive power of both constructs on the length of hospital stay...
  23. ncbi Subjective and objective quality of life, levels of life skills, and their clinical determinants in outpatients with schizophrenia
    Hirofumi Aki
    Department of Psychiatry, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima, Tokushima 770 8503, Japan
    Psychiatry Res 158:19-25. 2008
    ..Clinical symptoms were also assessed with several scales including the Brief Psychiatric Rating Scale (BPRS) and the Calgary Depression Scale for Schizophrenia (CDSS)...
  24. ncbi Symptom structure of acute mania: a factor study of the 24-item Brief Psychiatric Rating Scale in a national sample of patients hospitalized for a manic episode
    Angelo Picardi
    Italian National Institute of Health, Center of Epidemiology, Surveillance and Health Promotion, Mental Health Unit, Viale Regina Elena, 299 00161 Rome, Italy
    J Affect Disord 108:183-9. 2008
    ..Most studies included not only manic patients, but also patients with a mixed episode or other severe mental disorders. We aimed at further elucidating the symptom structure of manic states...
  25. ncbi Norms for the mini-mental state examination: adjustment of the cut-off point in population-based studies (evidences from the Bambuí health aging study)
    Erico Castro-Costa
    Public Health and Ageing Research Group, Medical School, Federal University of Minas Gerais, Belo Horizonte MG, Brazil
    Arq Neuropsiquiatr 66:524-8. 2008
    ....
  26. ncbi Meta-analysis of the brief psychiatric rating scale factor structure
    Alan Shafer
    Texas Health and Human Services Commission, Austin, TX 78711 3247, USA
    Psychol Assess 17:324-35. 2005
    A meta-analysis (N=17,620; k=26) of factor analyses of the Brief Psychiatric Rating Scale (BPRS) was conducted. Analysis of the 12 items from Overall et al.'s (J. E. Overall, L. E. Hollister, & P...
  27. ncbi The diagnostic accuracy of questions about past experiences of being mechanically restrained in a population of psychiatric patients
    Tuula Wallsten
    University of Uppsala, Vasteras, Sweden
    Memory 16:548-55. 2008
    ..No clear relationship between psychiatric symptoms and reliability of self-reports was identified. The results highlight the subjective qualities of narratives about past experiences...
  28. ncbi Stability of set-shifting and planning abilities in patients with schizophrenia
    Philip J Tyson
    School of Health and Social Sciences, University of Gloucestershire, Francis Close Hall Campus, Swindon Road, Cheltenham, Gloucestershire, GL50 4AZ, UK
    Psychiatry Res 129:229-39. 2004
    ..This study accords with the presence of executive processing deficits in schizophrenia that are stable across time...
  29. ncbi The treatment of negative symptoms and deficit states of chronic schizophrenia: olanzapine compared to amisulpride and placebo in a 6-month double-blind controlled clinical trial
    Y Lecrubier
    Pitié Salpétrière U 302 Hospital, Paris Cedex, France
    Acta Psychiatr Scand 114:319-27. 2006
    ..The aim of the study was to evaluate the efficacy of olanzapine (5 and 20 mg/day) over a 6-month period in chronic schizophrenic patients experiencing predominantly negative symptoms...
  30. ncbi High-frequency repetitive transcranial magnetic stimulation in schizophrenia: a combined treatment and neuroimaging study
    G Hajak
    Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany
    Psychol Med 34:1157-63. 2004
    ..In this context, disentangling of negative and depressive symptoms is of the utmost importance when understanding specific rTMS effects on schizophrenic symptoms...
  31. ncbi Frontal Systems Behavior Scale in schizophrenia: relationships with psychiatric symptomatology, cognition and adaptive function
    Dawn I Velligan
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, MS 7792, 7300 Floyd Curl Drive, San Antonio 78229, USA
    Psychiatry Res 113:227-36. 2002
    ..differential relationships were found for apathy and disinhibition with symptoms as rated from the Brief Psychiatric Rating Scale and with cognitive variables including Trails B and verbal fluency scores...
  32. ncbi The utility of intramuscular ziprasidone in the management of acute psychotic agitation
    Alan J Mendelowitz
    Department of Psychiatry, Albert Einstein University, Bronx, New York, USA
    Ann Clin Psychiatry 16:145-54. 2004
    ..This report focuses on the pharmacology, clinical efficacy, and tolerability of IM ziprasidone, and provides an overview of the utility of other commonly used antipsychotics in the management of acute psychotic agitation...
  33. pmc Apathy and the processing of novelty in schizophrenia
    Robert M Roth
    Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School DHMC, One Medical Center Drive, Lebanon, New Hampshire, 03756 0001, USA
    Schizophr Res 98:232-8. 2008
    ..The present findings indicate that schizophrenia is associated with slowed information processing, but do not support the hypothesis that apathy in schizophrenia is associated with abnormal processing of novelty...
  34. ncbi Comparison of older patients with bipolar disorder and schizophrenia/schizoaffective disorder
    Sanjay Gupta
    Department of Psychiatry, Olean General Hospital, Olean, NY, USA
    Am J Geriatr Psychiatry 15:627-33. 2007
    ..The aim of this cross-sectional study was to explore differences in measures of symptoms and cognition, side effects, and functional impairment between older patients with schizophrenia and bipolar disorder...
  35. ncbi Abnormal neurological signs at the onset of psychosis
    Russell E Scheffer
    Department of Psychiatry and Behavioral Medicine, The Medical College of Wisconsin, Milwaukee, WI, USA
    Schizophr Res 70:19-26. 2004
    ....
  36. pmc Neuropsychology of the deficit syndrome: new data and meta-analysis of findings to date
    Alex S Cohen
    Department of Psychology, University of Maryland, College Park, USA
    Schizophr Bull 33:1201-12. 2007
    ..The question of whether deficit patients exhibit a unique cognitive impairment profile will require a more sophisticated and rigorous examination of the neuropsychology of the deficit syndrome...
  37. pmc How neurocognition and social cognition influence functional change during community-based psychosocial rehabilitation for individuals with schizophrenia
    John S Brekke
    Schizophr Bull 33:1247-56. 2007
    ....
  38. ncbi Clozapine with amisulpride for refractory schizophrenia
    Marcus W Agelink
    Am J Psychiatry 161:924-5. 2004
  39. ncbi Pretreatment and longitudinal studies of neuropsychological deficits in antipsychotic-naïve patients with schizophrenia
    S Kristian Hill
    Center for Cognitive Medicine, Department of Psychiatry M C 913, University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL 60612, USA
    Schizophr Res 68:49-63. 2004
    ..Relatively static and generalized neuropsychological dysfunction, evident from illness onset, is consistent with neurodevelopmental rather than neurodegenerative models of schizophrenia...
  40. ncbi Correlation between scores on Continuous Performance Test and plasma concentration for schizophrenic patients on risperidone
    Po See Chen
    Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Psychiatry Clin Neurosci 58:168-72. 2004
    ..Both RIS and 9-OH-RIS have an impact on the CPT performance of schizophrenic patients. Optimal active moiety plasma concentration for best cognitive performance needs further study...
  41. ncbi Open label study of the effect of amantadine on weight gain induced by olanzapine
    Won Myong Bahk
    Department of Psychiatry, College of Medicine, Catholic University of Korea, Seoul, Korea
    Psychiatry Clin Neurosci 58:163-7. 2004
    ..All subjects were evaluated by weight, body mass index (BMI), the Brief Psychiatric Rating Scale (BPRS), and the Extrapyramidal Symptom Rating Scale (ESRS) before and after the use of amantadine in ..
  42. ncbi Changes over time in frontotemporal activation during a working memory task in patients with schizophrenia
    Robert Christian Wolf
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12 14, 89075 Ulm, Germany
    Schizophr Res 91:141-50. 2007
    ....
  43. ncbi A study of polypharmacy with second generation antipsychotics in patients with severe and persistent mental illness
    James L Megna
    Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    J Psychiatr Pract 13:129-37. 2007
    ..There is a paucity of empirical support for polypharmacy with second generation (atypical) antipsychotics (SGAs), especially in understudied populations...
  44. ncbi Relation of neurological soft signs to psychiatric symptoms in schizophrenia
    Vijay A Mittal
    Emory University, Department of Psychology, 235 Dental Building, 1462 Clifton Road, Atlanta, GA 30322, United States
    Schizophr Res 94:37-44. 2007
    ..The present study tests the associations between NSS and schizophrenia symptomatology and examines NSS as a potential marker for predicting treatment response...
  45. ncbi Schizophrenic patients treated with clozapine or olanzapine perform better on theory of mind tasks than those treated with risperidone or typical antipsychotic medications
    Ioulia Savina
    Department of Psychology, Queen s University, Kingston ON, Canada, K7L 3N6
    Schizophr Res 94:128-38. 2007
    ..We concluded that ToM performance of schizophrenic patients is influenced by the antipsychotic they are taking. Our results suggest that olanzapine or clozapine but not typicals or risperidone may improve or protect ToM ability...
  46. ncbi Switching to olanzapine after unsuccessful treatment with risperidone during the first episode of schizophrenia: an open-label trial
    Hitoshi Takahashi
    Yuri Kumiai General Hospital, Honjoh, Akita, Japan
    J Clin Psychiatry 67:1577-82. 2006
    ..The efficacy and safety of switching to olanzapine were investigated in patients with first-episode schizophrenia who failed to attain an adequate clinical response to an initial therapeutic trial of risperidone (2-6 mg/day for 12 weeks)...
  47. ncbi A practical clinical trial comparing haloperidol, risperidone, and olanzapine for the acute treatment of first-episode nonaffective psychosis
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, Santander, Spain
    J Clin Psychiatry 67:1511-21. 2006
    ....
  48. ncbi Demographic, clinical, and neurocognitive predictors of quality of life in schizophrenia patients receiving conventional neuroleptics
    Teresa L Sota
    Neurobehavioral Research Unit, St Michael s Hospital, Toronto, Ontario, Canada
    Compr Psychiatry 45:415-21. 2004
    ..Rehospitalization was related only to demographic data and previous hospital admissions. The findings support the predictive value of selected aspects of neurocognition in relation to a subjective outcome domain in schizophrenia...
  49. ncbi Analysis of resolution criteria in patients with schizophrenia treated with olanzapine for an acute psychotic episode
    Joseph Peuskens
    Universitair Psychiatrisch Centrum Katholieke Universiteit Leuven, Campus St Jozef Kortenberg, Leuvensesteenweg 517, 3070 Kortenberg, Belgium
    Schizophr Res 95:169-73. 2007
    ..Analysis of a 6-week open label study with olanzapine 5-20 mg in 306 patients with acute exacerbation, shows resolution to be a clinically meaningful measure and an achievable outcome for treatment of acute psychosis...
  50. ncbi Predictors of aggression on the psychiatric inpatient service
    Mark R Serper
    Department of Psychology, Hofstra University, Hempstead, NY 11549, USA
    Compr Psychiatry 46:121-7. 2005
    ..The need for relating predictors of specific types of aggressiveness in schizophrenia is discussed...
  51. ncbi Oral risperidone, olanzapine and quetiapine versus haloperidol in psychotic agitation
    Vincenzo Villari
    Emergency Department, Psychiatric Emergency Service, S Giovanni Hospital, Corso Bramante 88, 10126 Turin, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 32:405-13. 2008
    ..The aim of this study was to compare the effectiveness of three second generation antipsychotics (risperidone, olanzapine, quetiapine) versus haloperidol in the treatment of psychotic agitation for up to 72 h...
  52. ncbi Deficits in neurocognition, theory of mind, and social functioning in patients with schizophrenic disorders: are they related?
    Maryse Badan Bâ
    Division of Adult Psychiatry, Department of Psychiatry, Early Psychosis Program JADE, University Hospitals of Geneva, Geneva, Switzerland
    J Nerv Ment Dis 196:153-6. 2008
    ..The latter were the only 2 related to manic-hostility and negative symptoms subscores of Brief Psychiatric Rating Scale. Our findings suggest that there is no direct relation between neurocognitive impairments and social ..
  53. ncbi Subjective cognitive dysfunction in first-episode and chronic schizophrenic patients
    S Moritz
    Clinic for Psychiatry and Psychotherapy, University Clinic Hamburg-Eppendorf, Hamburg, Germany
    Compr Psychiatry 42:213-6. 2001
    ..In marked contrast to a Kraepelinian view of schizophrenia, the present data confirm previous studies conducted with objective neuropsychological tests that schizophrenia is a neurodevelopmental rather than a neurodegenerative disorder...
  54. ncbi Clinical effects of a randomized switch of patients from clozaril to generic clozapine
    J C Kluznik
    Saint Peter Regional Treatment Center, Forensic Division, St Peter, Minn 50682, USA
    J Clin Psychiatry 62:14-7; discussion 23-4. 2001
    ..Efficacy was measured with the Clinical Global Impressions-Improvement (CGI-I) scale, the Brief Psychiatric Rating Scale (BPRS), and the Beck Depression Inventory (BDI)...
  55. ncbi Six-month, blinded, multicenter continuation study of ziprasidone versus olanzapine in schizophrenia
    George M Simpson
    Department of Psychiatry and the Behavioral Sciences, LAC USC Medical Center, IRD RM 204, Psychiatric Outpatient Clinic, 2020 Zonal Ave, Los Angeles, CA 90033, USA
    Am J Psychiatry 162:1535-8. 2005
    ..The authors' goal was to compare the efficacy and tolerability of 6 months' treatment with flexible-dose ziprasidone and olanzapine in patients with schizophrenia or schizoaffective disorder...
  56. ncbi Superior efficacy of olanzapine over haloperidol: analysis of patients with schizophrenia from a multicenter international trial
    J C Gomez
    Eli Lilly Spain, Alcobendas, Madrid
    J Clin Psychiatry 62:6-11. 2001
    ..An analysis of variance was used to compare treatment effects on efficacy measurements including the Brief Psychiatric Rating Scale (BPRS; scored 0-6) and the Positive and Negative Syndrome Scale (total, positive subscale, and ..
  57. pmc Assessment of medication management ability in middle-aged and older adults with bipolar disorder
    Colin A Depp
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Clin Psychopharmacol 28:225-9. 2008
    ..correlation was seen between MMAA scores and the DRS Total score, but not with age, education, Brief Psychiatric Rating Scale, Hamilton Depression Rating Scale, number of psychiatric medications, or medical conditions...
  58. ncbi Effective resolution with olanzapine of acute presentation of behavioral agitation and positive psychotic symptoms in schizophrenia
    B J Kinon
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Ind 46285, USA
    J Clin Psychiatry 62:17-21. 2001
    ..olanzapine (5-20 mg/day) or haloperidol (5-20 mg/day) assessed the treatment effects on agitation (Brief Psychiatric Rating Scale [BPRS] agitation score) and positive symptoms (BPRS positive symptom score)...
  59. pmc Cognitive correlates of schizophrenia signs and symptoms: I. Verbal communication disturbances
    Howard Berenbaum
    Department of Psychology, University of Illinois at Urbana Champaign, Champaign, IL 61820, United States
    Psychiatry Res 159:147-56. 2008
    ..Alogia and discourse coherence were differentially associated with performance on tasks measuring fluency, working memory, word finding abilities, and concentration/attention...
  60. ncbi Neurocognitive and social cognitive correlates of formal thought disorder in schizophrenia patients
    Kenneth L Subotnik
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 90095 6968, USA
    Schizophr Res 85:84-95. 2006
    ..This pattern of findings is consistent with the view that neurocognitive and, possibly, social cognitive deficits underlie these two aspects of formal thinking disturbance in schizophrenia...
  61. ncbi Comorbid anxiety disorders and divalproex sodium use among partial hospital patients with psychotic disorders
    Mark H Townsend
    Department of Psychiatry, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Compr Psychiatry 46:368-70. 2005
    ..Each subject was diagnosed by structured interview, and 4 Brief Psychiatric Rating Scale (BPRS) items associated with agitation were assessed: anxiety, hostility, excitement, and tension...
  62. ncbi Control group bias in randomized atypical antipsychotic medication trials for schizophrenia
    Scott W Woods
    Treatment Research Program, Department of Psychiatry and Biostatistics Division, Yale University School of Medicine, New Haven, Conn 06519, USA
    Arch Gen Psychiatry 62:961-70. 2005
    ..This strategy requires an assumption of constancy, that the novel medication will perform the same way in a study with only active controls as it would have in a placebo-controlled trial...
  63. ncbi Negative signs and symptoms secondary to antipsychotics: a double-blind, randomized trial of a single dose of placebo, haloperidol, and risperidone in healthy volunteers
    Juan Francisco Artaloytia
    Hospital Universitario 12 de Octobre, Madrid, Spain
    Am J Psychiatry 163:488-93. 2006
    ..The present study assessed observer-rated and self-rated negative symptoms produced by conventional and second-generation antipsychotics in healthy volunteers...
  64. ncbi Neuropsychological functions predict 1- and 3-year outcome in first-episode psychosis
    R Carlsson
    Department of Psychology, Lund University, Lund, Sweden
    Acta Psychiatr Scand 113:102-11. 2006
    ..To examine neuropsychological performance as a possible predictor of course and outcome in first-episode psychotic (FEP) patients...
  65. ncbi Ziprasidone-induced cognitive enhancement in schizophrenia: specificity or pseudospecificity?
    Anil K Malhotra
    Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, and Albert Einstein College of Medicine, United States
    Schizophr Res 87:181-4. 2006
    ..We tested the hypothesis that ziprasidone improves cognition in the absence of clinical improvement...
  66. ncbi Risperidone dosing pattern and clinical outcome in psychosis: an analysis of 1713 cases
    Chang Yoon Kim
    Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    J Clin Psychiatry 66:887-93. 2005
    ..To evaluate the outcome of different risperidone dosing strategies in clinical practice, we undertook a large, prospective, naturalistic study in which daily dosage was determined freely by local standards of care...
  67. ncbi Management of antipsychotic-induced weight gain: prospective naturalistic study of the effectiveness of a supervised exercise programme
    Marie Josée Poulin
    Centre Hospitalier Affilie Universitaire De Quebec, Hôpital de l Enfant Jésus and Centre Hospitalier Robert Giffard, Quebec City, Quebec, Canada
    Aust N Z J Psychiatry 41:980-9. 2007
    ....
  68. ncbi Correlations between negative symptoms and peripheral G protein levels in mononuclear leukocytes of deficit and nondeficit schizophrenics. Preliminary results
    Palmiero Monteleone
    Department of Psychiatry, University of Naples S U N, Largo Madonna delle Grazie, 80138 Naples, Italy
    Eur Arch Psychiatry Clin Neurosci 252:214-8. 2002
    ..These results must be regarded as preliminary because of the possible interference of antipsychotic drugs on the explored parameters...
  69. ncbi Facial recognition deficits and cognition in schizophrenia
    Gabriele Sachs
    Department of Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Schizophr Res 68:27-35. 2004
    ..001). The study did not reveal a specific deficit for emotion recognition in schizophrenia. These findings lend support to the notion that difficulties in emotion recognition are associated in schizophrenia with key cognitive deficits...
  70. ncbi Symptom rating scales and outcome in schizophrenia
    Ann M Mortimer
    Department of Psychiatry, University of Hull
    Br J Psychiatry Suppl 50:s7-14. 2007
    ..Symptom rating scales are now well established in schizophrenia research but their scores are not the same as outcome...
  71. ncbi Classifying episodes in schizophrenia and bipolar disorder: criteria for relapse and remission applied to recent-onset samples
    Keith H Nuechterlein
    UCLA Department of Psychiatry and Biobehavioral Sciences, 300 UCLA Medical Plaza, Room 2251, Los Angeles, CA 90095 6968, United States
    Psychiatry Res 144:153-66. 2006
    ....
  72. ncbi Efficacy of aripiprazole against hostility in schizophrenia and schizoaffective disorder: data from 5 double-blind studies
    Jan Volavka
    The Nathan Kline Institute and New York University, 140 Old Orangeburg Road, Orangeburg, N Y 10962, USA
    J Clin Psychiatry 66:1362-6. 2005
    ..The objective was to determine the effects of aripiprazole on hostility...
  73. ncbi The effects of clozapine and risperidone on spatial working memory in schizophrenia
    Susan R McGurk
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Pl, New York, NY 10029, USA
    Am J Psychiatry 162:1013-6. 2005
    ..The purpose of this investigation was to evaluate the effects of clozapine and risperidone on spatial working memory in patients with schizophrenia...
  74. ncbi Socioeconomic status of origin and the clinical expression of Schizophrenia
    Brooke Parrott
    Department of Psychological and Brain Sciences, University of Louisville, KY 40292, USA
    Schizophr Res 75:417-24. 2005
    ..Possible interactions between socioeconomic status and sex of patient are discussed, as well as suggestions for further study...
  75. ncbi Depression in schizophrenia: comparison of first- and second-generation antipsychotic drugs
    Massimo C Mauri
    Clinical Psychiatry, University of Milan, Clinical Neuropsychopharmacology Unit, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via F Sforza 35, 20122 Milano, Italy
    Schizophr Res 99:7-12. 2008
    ..The Brief Psychiatric Rating Scale (BPRS), Extrapyramidal Side Effects Rating Scale (EPSE) and Anticholinergic Rating Scale (ACS) were ..
  76. ncbi A six-factor model of cognition in schizophrenia and related psychotic disorders: relationships with clinical symptoms and functional capacity
    Julie Akiko Gladsjo
    Department of Psychiatry, University of California, San Diego 92161, USA
    Schizophr Bull 30:739-54. 2004
    ..A simultaneous confirmatory factor analysis using the original sample and a group of healthy subjects (n = 131) demonstrated that the six-factor model of cognition was generalizable and applied equally well to both groups...
  77. ncbi Clozapine and haloperidol in moderately refractory schizophrenia: a 6-month randomized and double-blind comparison
    J M Kane
    Department of Psychiatry, Hillside Hospital, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 58:965-72. 2001
    ..hostile-suspiciousness, anxiety-depression, thought disturbance, and total score measured on the Brief Psychiatric Rating Scale. No differences were detected in negative symptoms using the Brief Psychiatric Rating Scale or the ..
  78. pmc Comparison of clozapine response for inpatients in the research setting versus routine clinical practice
    Douglas L Boggs
    Maryland Psychiatric Research Center, School of Medicine, University of Maryland Baltimore, Baltimore, MD 21228, USA
    Psychiatr Q 79:111-9. 2008
    ..This study compares patient characteristics and treatment response between inpatients treated with clozapine in a research setting as compared to those initiated on clozapine during routine inpatient treatment...
  79. ncbi Psychopathology and neuropsychological impairments in deficit and nondeficit schizophrenia of Chinese origin
    Xiang Wang
    The Medical Psychological Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China
    Psychiatry Res 158:195-205. 2008
    ..Schizophrenia patients completed the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS) and Scale for the Assessment of Positive ..
  80. ncbi One-year outcome after response to ECT in middle-aged and elderly patients with intractable catatonic schizophrenia
    Kazumasa Suzuki
    Department of Psychiatry, Tohoku University Graduate School of Medicine, Aoba ku, Sendai, Japan
    J ECT 20:99-106. 2004
    ..Thus, we conducted prospective studies on the short-term (phase 1 study) and long-term (phase 2 study) effects of acute ECT on intractable catatonic schizophrenia in middle-aged and elderly patients...
  81. ncbi Clozapine utilization and outcomes by race in a public mental health system: 1994-2000
    Deanna L Kelly
    Maryland Psychiatric Research Center, University of Maryland, Baltimore 21228, USA
    J Clin Psychiatry 67:1404-11. 2006
    ..This study extends previous studies of clozapine by examining patient- and treatment-related factors that may help explain or eliminate reasons for differential prescribing...
  82. ncbi The clinical effectiveness and cost of repetitive transcranial magnetic stimulation versus electroconvulsive therapy in severe depression: a multicentre pragmatic randomised controlled trial and economic analysis
    D M McLoughlin
    Section of Old Age Psychiatry, Institute of Psychiatry, London, UK
    Health Technol Assess 11:1-54. 2007
    ..To investigate if repetitive transcranial magnetic stimulation (rTMS) was as effective as electroconvulsive therapy (ECT) in treating major depressive episodes and to perform a cost-effectiveness analysis...
  83. ncbi Short-term effect of ECT in middle-aged and elderly patients with intractable catatonic schizophrenia
    Kazumasa Suzuki
    Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan
    J ECT 19:73-80. 2003
    ..Thus, we conducted a prospective study of the short-term effect of acute ECT on middle-aged and elderly patients with intractable catatonic schizophrenia...
  84. ncbi Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol
    Akihito Suzuki
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    Ther Drug Monit 25:192-6. 2003
    ..or homochlorcyclizine and 1 week after the discontinuation, together with clinical assessments by Brief Psychiatric Rating Scale (BPRS) and Udvalg for kliniske undersogelser (UKU) side effect rating scale...
  85. ncbi Neuroendocrine serotonergic and dopaminergic responsivity in male schizophrenic patients during treatment with neuroleptics and after switch to risperidone
    M Markianos
    Athens University Medical School, Psychiatric Clinic, Eginition Hospital, Vass Sophias 74, 11528 Athens, Greece
    Psychopharmacology (Berl) 157:55-9. 2001
    ....
  86. ncbi Neuropsychiatric aspects of HIV disease progression: impact of traditional herbs on adult patients in Zimbabwe
    Mohamedi B Sebit
    Department of Psychiatry, University of Zimbabwe Medical School, Avondale, Harare, Zimbabwe
    Prog Neuropsychopharmacol Biol Psychiatry 26:451-6. 2002
    ..Instruments used were the Brief Psychiatric Rating Scale (BPRS), Montgomery-Asberg Depression Rating Scale (MADRS), Structured Interview Diagnosis of Dementia ..
  87. ncbi [Causes and psychosocial consequences of schizophrenia: the opinions of patient's relatives]
    L Magliano
    Istituto di Psichiatria, Università di Napoli SUN
    Epidemiol Psichiatr Soc 9:113-25. 2000
    ....
  88. ncbi Meta-analysis comparing newer antipsychotic drugs for the treatment of schizophrenia: evaluating the indirect approach
    L Sauriol
    Aventis Pharma Canada Inc, Laval, Quebec
    Clin Ther 23:942-56. 2001
    ..Meta-analysis is a useful method to assess the efficacy of newer antipsychotic drugs compared with older drugs or placebo. However, few trials directly compare novel drugs to each other...
  89. ncbi Clozapine-induced weight gain predicts improvement in psychopathology
    Herbert Y Meltzer
    Department of Psychiatry, Psychiatric Hospital at Vanderbilt, Vanderbilt University School of Medicine, 1601 23rd Avenue South 306, Nashville, TN 37215, USA
    Schizophr Res 59:19-27. 2003
    ..The purpose of this study was to test the hypothesis that clozapine-induced weight gain is related to antipsychotic efficacy at 6 weeks and 6 months after adjusting for initial body weight and severity of illness...
  90. ncbi Clozapine and olanzapine are associated with food craving and binge eating: results from a randomized double-blind study
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, Germany
    J Clin Psychopharmacol 27:662-6. 2007
    ..study comparing abnormal eating behavior using a standardized scale, clinical efficacy using the Brief Psychiatric Rating Scale 0-6 and Clinical Global Impression-Severity scale, and tolerability of clozapine and olanzapine...
  91. ncbi Atypical neuroleptics in acute schizophrenia: a double-blind comparative study of remoxipride and haloperidol
    J A Den Boer
    University Hospital, Department of Biological Psychiatry, Utrecht, The Netherlands
    Psychopharmacol Bull 26:99-107. 1990
    ..Symptoms assessment was performed using the Brief Psychiatric Rating Scale (BPRS), the Clinical Global Impressions (CGI) and the Present State Examination (PSE)...
  92. ncbi Quetiapine improves visual hallucinations in Parkinson disease but not through normalization of sleep architecture: results from a double-blind clinical-polysomnography study
    Hubert H Fernandez
    Department of Neurology, College of Medicine, University of Florida, FL, USA
    Int J Neurosci 119:2196-205. 2009
    ..The Clinical Global Impression Scale (CGIS), Brief Psychiatric Rating Scale (BPRS), and Unified Parkinson Disease Rating Scale (UPDRS) motor subscale were obtained...
  93. ncbi A double-blind, placebo-controlled trial of extract of Ginkgo biloba added to haloperidol in treatment-resistant patients with schizophrenia
    X Y Zhang
    Yale University School of Medicine, Neuropsychopharmacology Lab, New Haven, CT 06520 8066, USA
    J Clin Psychiatry 62:878-83. 2001
    ..The aim of this study was to determine the effectiveness and to evaluate the side effects of extract of Ginkgo biloba (EGb) plus haloperidol in chronic, treatment-resistant inpatients with schizophrenia...
  94. ncbi Antipsychotic efficacy of the antidepressant trimipramine: a randomized, double-blind comparison with the phenothiazine perazine
    S Bender
    University of Essen, Clinic for Psychiatry and Psychotherapy, Germany
    Pharmacopsychiatry 36:61-9. 2003
    ..The aim of the study was to investigate the antipsychotic potential of trimipramine in a controlled clinical trial comparing its antipsychotic efficacy with that of a neuroleptic...
  95. ncbi Continuation electroconvulsive therapy for relapse prevention in middle-aged and elderly patients with intractable catatonic schizophrenia
    Kazumasa Suzuki
    Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Psychiatry Clin Neurosci 59:481-9. 2005
    ..Clinical symptoms were evaluated by means of the Brief Psychiatric Rating Scale (BPRS) weekly for 48 weeks or until relapse...
  96. ncbi Tolerability of remoxipride in the long term treatment of schizophrenia. An overview
    A C Holm
    Department of CNS Clinical Research, Astra Arcus AB, Sodertalje, Sweden
    Drug Saf 8:445-56. 1993
    ..Remoxipride was administered in daily doses of 75 to 600mg. The assessment tools were Brief Psychiatric Rating Scale (BPRS), Clinical Global Impression (CGI), Simpson and Angus scale, Abnormal Involuntary Movements ..
  97. ncbi Further validation of the Chinese version of the Level of Expressed Emotion Scale for research and clinical use
    Wai Tong Chien
    The School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnics University, Hung Hom, Kowloon, Hong Kong, China
    Int J Nurs Stud 47:190-204. 2010
    ..In Western countries this construct is used as an outcome measure of interventions for families of people with schizophrenia or other psychotic disorders, but the use of this construct in Chinese populations is somewhat limited...
  98. ncbi High serum creatinine kinase level: possible risk factor for neuroleptic malignant syndrome
    Haggai Hermesh
    Geha Psychiatric Hospital and Felsenstein Medical Research Center, Petah Tiqva, Israel
    J Clin Psychopharmacol 22:252-6. 2002
    ..transaminase (SGOT), and white blood cell count (WBC) during all non-NMS psychotic episodes (Brief Psychiatric Rating Scale 40) were averaged...
  99. pmc Levomepromazine versus chlorpromazine in treatment-resistant schizophrenia: a double-blind randomized trial
    Samarthji Lal
    Douglas Hospital Research Centre, 6875 LaSalle Boulevard, Verdun, Montreal, Quebec
    J Psychiatry Neurosci 31:271-9. 2006
    ..We compared the effect of levomepromazine (LMP) with chlorpromazine (CPZ) in treatment-resistant schizophrenia (TRS)...
  100. ncbi Relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics
    E Spina
    Centers of Mental Health, Azienda USL 5, Messina, Italy
    Psychopharmacology (Berl) 148:83-9. 2000
    ..Monitoring plasma clozapine concentrations may play a useful role in the management of patients with schizophrenia, but information on the relationship between the plasma levels of the drug and response is still controversial...
  101. ncbi Characteristics of trees drawn by patients with paranoid schizophrenia
    Hiroyuki Inadomi
    Department of Occupational Therapy, School of Health Sciences, Nagasaki University, Sakamoto, Nagasaki, Japan
    Psychiatry Clin Neurosci 57:347-51. 2003
    ..Differences in psychiatric symptoms as assessed using the Brief Psychiatric Rating Scale (BPRS) score were compared between patients with paranoid and non-paranoid schizophrenia...

Research Grants62

  1. Detecting Which Patients With Schizophrenia Will Improve With Omega 3 Treatment
    Philip R Szeszko; Fiscal Year: 2013
    ..be obtained prior to the initiation of treatment and the primary outcome measure will be the total Brief Psychiatric Rating Scale Score...
  2. Eltoprazine for the Treatment of Cognitive Dysfunction Assoc. With Schizophrenia
    Emer Leahy; Fiscal Year: 2012
    ..whether eltoprazine has an effect on positive, negative or affective symptoms by administering the Brief Psychiatric Rating Scale (BPRS) for positive symptoms, Calgary Depression Scale (CDS) for depression, Scale for Assessment of ..
  3. GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTS
    DEEPAK D SOUZA; Fiscal Year: 2002
    ..Clinician Administered Dissociative Symptom Scale), negative and positive symptoms of psychosis (Brief Psychiatric Rating Scale), recall (Hopkins Verbal Learning Test) and working memory will be administered...
  4. INTELLIGENT REFRIGERATED AUTOMATIC STORAGE SYSTEM
    DAN CORNELL; Fiscal Year: 1993
    ..Measures of efficacy include the Brief Psychiatric Rating Scale (BPRS), Clinical Global Improvement Scale (CGI), Hamilton Rating Scale for Depression, Relatives' ..
  5. EFFECTS IN SCHIZOPHRENICS VERSUS HEALTHY CONTROLS.
    DEEPAK D SOUZA; Fiscal Year: 1999
    ..The primary outcome measures include: 1) 4 key positive and 3 key negative symptom subscales, of the Brief Psychiatric Rating Scale (BARS) 2) tests sensitive to frontal and temporal cortical function: Continuous Performance Test and ..
  6. ALZHEIMER'S IN LONG TERM PROPRANOLOL FOR AGITATION
    Elaine Peskind; Fiscal Year: 2003
    ..Clinical Global Impression of Change score and change scores from baseline to last observation on the Brief Psychiatric Rating Scale and Neuropsychiatric Inventory. Cognition, functional status, and adverse events will also be assessed...
  7. ACUTE MANIA--HALOPERIDOL DOSE AND LORAZEPAM AUGMENTATION
    James Chou; Fiscal Year: 1993
    ..HAL, Li and LZP blood levels will be measured weekly. Clinical ratings will include the Brief Psychiatric Rating Scale (BPRS), Clinical Global Impression, and Manic-State Rating Scale...
  8. NEUROPATHOLOGY OF DEMENTIA IN ELDERLY SCHIZOPHRENICS
    STEVEN ARNOLD; Fiscal Year: 1999
    ..standardized chart review, clinical diagnostic examinations, and clinical rating scales including the Brief Psychiatric Rating Scale, the Scale for the Assessment of Negative Symptoms, the Scale for the Assessment of Positive Symptoms, ..
  9. SELF HELP AND SEVERE MENTAL ILLNESS
    Caroline Kaufmann; Fiscal Year: 1992
    ..The primary outcomes to be assessed are: psychiatric symptoms as assessed by the Brief Psychiatric Rating Scale and the Scale for the Assessment of Negative Symptoms, rehospitalization following discharge to the ..
  10. Comorbid Substance Abuse and Long-Term Health Outcomes in Schizophrenia
    DEANNA KELLY; Fiscal Year: 2008
    ..This will be an important step for improving the lives of people with schizophrenia. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  11. Cardiac-Related Mortality with Atypical Antipsychotics
    DEANNA KELLY; Fiscal Year: 2005
    ..This study is important as data on long-term health outcomes with atypical antipsychotics is lacking from the literature. ..
  12. Compensating for Cognitive Deficits in Schizophrenia
    Dawn Velligan; Fiscal Year: 2005
    ..abstract_text> ..
  13. MEDICATION ADHERENCE AND OUTCOMES IN SCHIZOPHRENIA
    Dawn Velligan; Fiscal Year: 2004
    ..Moreover, we hypothesize that compliance and functioning will return to baseline levels six months after discontinuation of treatment. ..
  14. Naltrexone for Bipolar Disorder and Alcohol Dependence
    E Sherwood Brown; Fiscal Year: 2006
    ..Alcohol use is the primary outcome, and alcohol craving is the secondary outcome. Manic and depressive symptom severity and the relationship between changes in alcohol use and changes in mood will be expIored. ..
  15. Treating Asthma Patients with Major Depressive Disorder
    E Sherwood Brown; Fiscal Year: 2004
    ....
  16. HIPPOCAMPAL FUNCTION DURING CORTICOSTEROID THERAPY
    E Sherwood Brown; Fiscal Year: 2004
    ..Through this award, the Pl will extend his previous research experience by adding new skills and knowledge which will be used for investigations at the interface of neuroscience and clinical research. ..
  17. Interventions for Adherence to Oral Antipsychotic Medications in Schizophrenia
    DAWN IRENE VELLIGAN; Fiscal Year: 2010
    ..The public health implications include effective disease management, maximizing long-term outcomes, and containing health care costs for schizophrenia. ..
  18. Electrophysiological Correlates of Anhedonia in Schizophrenia
    WILLIAM HORAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. Advanced Centers for Interventions and Services Research
    Robert Buchanan; Fiscal Year: 2007
    ....
  20. Transdisciplinary Imaging Genetics Center (1 of 2)(RMI)
    Steven Potkin; Fiscal Year: 2006
    ..The new knowledge generated by the Center holds considerable promise for improving diagnosis and treatment of mental illness. [unreadable] [unreadable]..
  21. Identifying molecular path of behavioural phenotype in schizophrenia
    L Hong; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. Liability Markers for Deficit Schizophrenia?
    L Hong; Fiscal Year: 2004
    ..We plan to use the preliminary data collected from this grant support to guide our full-scale search for phenotypic markers specifically associated with the liability for deficit schizophrenia and subsequent molecular genetic studies. ..
  23. The Effects of the Cannabinoid-1 Receptor Antagonist Rimonabant on Weight...
    Robert Buchanan; Fiscal Year: 2008
    ..There should be direct evidence of efficacy and safety in these patients in order to provide truly effective treatments and further understanding of these disorders. [unreadable] [unreadable] [unreadable]..
  24. Clozapine Treatment of Schizophrenic Patients
    Robert Buchanan; Fiscal Year: 2006
    ..The study will provide new information on the clinical utility of adjunctive risperidone in treatment-resistant patients who fail to adequately respond to clozapine. ..
  25. THE NEURAL CIRCUITRY OF SENSORIMOTOR GATING
    Erin Hazlett; Fiscal Year: 2002
    ....
  26. Neural Substrates of Emotion in Borderline Patients
    Erin Hazlett; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  27. Brain Abnormalities in Adolescent Bipolar Disorder
    Melissa Delbello; Fiscal Year: 2006
    ..The research conducted will advance our understanding of the neurophysiology of BPD. ..
  28. Clinical Ratings of Neurocognition (CRON)
    Joseph Ventura; Fiscal Year: 2007
    ..The proposed developments are urgently needed to continue the momentum established by the MATRICS initiative, and facilitate regulatory acceptance and clinical awareness of new treatments for CIAS. [unreadable] [unreadable] [unreadable]..
  29. Topiramate for Co-occurring Cannabis Use and Bipolar Disorders in Adolescents
    Melissa Delbello; Fiscal Year: 2008
    ..The preliminary data from this projectwill inform and guide the design of future larger, more definitive, controlled studies of topiramate as a treatment for adolescent substance use disorders. ..
  30. Stress Reactivity & Protective Factors in Schizophrenia
    Joseph Ventura; Fiscal Year: 2003
    ..abstract_text> ..
  31. Smoking Cessation and Smoking Relapse Prevention in Patients with Schizophrenia
    A Eden Evins; Fiscal Year: 2010
    ..Participants will then discontinue study medications and enter a 3-month follow up. The primary outcome measure will be 7-day point prevalence abstinence rate at 12 months in the intervention vs. placebo groups. ..
  32. Glycine Transport Inhibition for Nicotine Dependence in Schizophrenia
    A Evins; Fiscal Year: 2009
    ....
  33. NICOTINE AND SMOKING CESSATION IN SCHIZOPHRENIA
    A Evins; Fiscal Year: 2005
    ....
  34. Manic Distractibility and Frontosubcortical Processing
    DAVID FLECK; Fiscal Year: 2007
    ..abstract_text> ..
  35. Apathy in Alzheimer's Disease Methylphenidate Trial
    Paul B Rosenberg; Fiscal Year: 2010
    ..This study aims to develop a new treatment for apathy in AD that could decrease its debilitating consequences and reduce patients'dependency on caregivers, providing well-deserved relief to patients and their loved ones. ..
  36. DEVELOPMENTAL PROCESSES IN SCHIZOPHRENIC DISORDERS
    Keith H Nuechterlein; Fiscal Year: 2010
    ..Potential predictors of response to these treatments will be evaluated. ..
  37. AMINO ACID NEUROTRANSMITTER DYSREGULATION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2008
    ..abstract_text> ..
  38. Institute for Research Minority Training on Mental Health
    Jacobo Mintzer; Fiscal Year: 2007
    ..We expect this effort to be the incubator for a new generation of minority researchers dedicated to the study mental health and aging. ..
  39. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    EDITH VIONI SULLIVAN; Fiscal Year: 2010
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  40. Metabolic Effects of Newer Antipsychotics in Older Pts
    Dilip Jeste; Fiscal Year: 2009
    ..abstract_text> ..
  41. An Evaluation of Sober Living Houses
    Douglas Polcin; Fiscal Year: 2007
    ..Finally, it will demonstrate whether sober living residents have better outcomes than a comparison group of similar individuals. ..
  42. A Culturally-Based Family Therapy for Schizophrenia
    Amy Weisman; Fiscal Year: 2007
    ..The Pi's long term goal is to develop effective culturally informed family interventions for schizophrenia and related disorders, in Spanish and in English. [unreadable] [unreadable] [unreadable]..
  43. ASSERTIVE COMMUNITY TREATMENT FOR THE DUALLY DIAGNOSED
    Robert Drake; Fiscal Year: 2004
    ..Finally, we will take maximal advantage of conducting the rural and urban studies in conjunction with one another. ..
  44. INTERVENTION RESEARCH TRAINING FOR THE PSYCHOSES
    Keith Nuechterlein; Fiscal Year: 2004
    ..D.s and the other half Ph.D.s. Trainees will be assigned to primary and secondary mentors who will supervise their training activities in an individualized research mentorship model. ..
  45. Risk and Resilience in Youth with HIV+ Mothers
    Claude Mellins; Fiscal Year: 2003
    ..At the end of Phase 2, we aim to have a feasible, culturally sensitive, effective prevention intervention that can be tested in a larger clinical trial with early adolescents affected by maternal HIV disease. ..
  46. Chinese Exercise Modalites in Parkinson's Disease
    Jorge Juncos; Fiscal Year: 2003
    ..A better understanding of exercise-induced neural plasticity and motor control would offer a significant, and heretofore unexploited rehabilitative potential in PD. ..
  47. AMINO ACID NEUROTRANSMITTER DYSREGULATION IN ALCOHOLISM
    John Krystal; Fiscal Year: 2003
    ..In summary, this K02 award would foster my academic development and enable me to better contribute to the building of pathophysiologic models of alcoholism that can guide medications development for this disorder. ..
  48. Treatment Response to Rehabilitation in Schizophrenia
    Matthew Kurtz; Fiscal Year: 2002
    ..abstract_text> ..
  49. PROSPECTIVE STUDY OF TARDIVE DYSKINESIA DEVELOPMENT
    John Kane; Fiscal Year: 2001
    ..This strategy will provide a rapid and cost-effective answer to a critical question. ..
  50. Treating Agitation/Psychosis in Dementia/Parkinsonism
    Roger Kurlan; Fiscal Year: 2004
    ..This study will provide important information regarding the optimal treatment of psychosis and agitation for patients with the commonly encountered combination of primary dementia and parkinsonism. ..
  51. Multiple Factors Affecting Placebo Response in PD
    Christopher Goetz; Fiscal Year: 2004
    ..Defining these determinant influences will help enhance placebo responses in clinical practice and control them in clinical trials. ..
  52. TREATMENT AND OUTCOME OF EARLY ONSET BIPOLAR DISORDER
    Vivian Kafantaris; Fiscal Year: 2005
    ..In addition, a lower risk of TD with the novel antipsychotics may alter the risk: benefit ratio in favor of longer-term antipsychotic treatment. ..
  53. Depressoin in Alzheimer's Disease Study-2 (DIADS-2)
    Jacobo Mintzer; Fiscal Year: 2007
    ..abstract_text> ..
  54. Collaborative Pediatric Bipolar Disorder Conference
    Joseph Biederman; Fiscal Year: 2007
    ..While the proposed conference does not intend to solve all outstanding problems associated with pediatric bipolar disorder, it will provide a forum to begin formulating a solution. ..
  55. Promoting Adherence to Treatment in Schizophrenia
    Alex Kopelowicz; Fiscal Year: 2006
    ..abstract_text> ..
  56. Treatment Effectiveness for Anxiety and Depression
    Ariel Lang; Fiscal Year: 2006
    ..The second phase of research will involve pilot studies and preparation of a research project grant (RO1) application to test the generalizability of this intervention to community settings with administration by non-expert clinicians. ..
  57. Rehabilitation and Health Care for Older Adults with SMI
    Stephen Bartels; Fiscal Year: 2005
    ..abstract_text> ..
  58. Cognitive reserve and age-related brain changes
    Adam Brickman; Fiscal Year: 2005
    ..Results from the study will provide important insights into the normal aging process and will yield valuable information towards understanding the underpinnings of age-associated pathologies. ..
  59. Hippocampus/Pituitary Ratio: an AD Brain Injury Marker?
    Thomas Beresford; Fiscal Year: 2005
    ..abstract_text> ..
  60. Predicting Positive Outcomes among Cancer Survivors
    Stephanie Reid Arndt; Fiscal Year: 2005
    ..By elucidating factors associated with positive and/or negative outcomes among cancer survivors, this project will serve as a foundation for future intervention programs and future research examining long-term functional outcomes. ..
  61. PREVENTION OF CIGARETTE SMOKING IN ADHD YOUTH
    Joseph Biederman; Fiscal Year: 2001
    ..Since there are estimated to be 3.5 million children with ADHD and 20% have been shown to be smokers, targeting this group could potentially impact 700,000 children and adolescents. ..