behavioral genetics

Summary

Summary: The experimental study of the relationship between the genotype of an organism and its behavior. The scope includes the effects of genes on simple sensory processes to complex organization of the nervous system.

Top Publications

  1. ncbi Behavioral alterations induced by repeated testing in C57BL/6J and 129S2/Sv mice: implications for phenotyping screens
    V Voikar
    Neuroscience Center and Department of Biosciences, University of Helsinki, Finland
    Genes Brain Behav 3:27-38. 2004
  2. ncbi Ain't misbehavin' ? Genotype-environment interactions and the genetics of behavior
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Trends Genet 23:311-4. 2007
  3. pmc Caenorhabditis elegans behavioral genetics: where are the knobs?
    Leon Avery
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    BMC Biol 8:69. 2010
  4. doi Behavioral genetics in antisocial spectrum disorders and psychopathy: a review of the recent literature
    Tracy D Gunter
    Associate Professor, Saint Louis University Department of Neurology and Psychiatry, 1438 S Grand Blvd, St Louis, MO 63104, USA
    Behav Sci Law 28:148-73. 2010
  5. ncbi Mouse models of autism spectrum disorders: the challenge for behavioral genetics
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Med Genet C Semin Med Genet 142:40-51. 2006
  6. pmc Behavioral genetics and child temperament
    Kimberly J Saudino
    Psychology Department, Boston University, Boston, Massachusetts 02215, USA
    J Dev Behav Pediatr 26:214-23. 2005
  7. ncbi The varieties of selectional experience in behavioral genetics
    Ralph J Greenspan
    The Neurosciences Institute, San Diego, CA 92121, USA
    J Neurogenet 17:241-70. 2003
  8. ncbi Variance components models for gene-environment interaction in twin analysis
    Shaun Purcell
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK
    Twin Res 5:554-71. 2002
  9. ncbi Likelihood ratio tests in behavioral genetics: problems and solutions
    Annica Dominicus
    Department of Mathematics, Stockholm University, Stockholm, Sweden
    Behav Genet 36:331-40. 2006
  10. ncbi Quantitative genetic analyses of complex behaviours in Drosophila
    Robert R H Anholt
    Department of Zoology, W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Nat Rev Genet 5:838-49. 2004

Research Grants

Detail Information

Publications208 found, 100 shown here

  1. ncbi Behavioral alterations induced by repeated testing in C57BL/6J and 129S2/Sv mice: implications for phenotyping screens
    V Voikar
    Neuroscience Center and Department of Biosciences, University of Helsinki, Finland
    Genes Brain Behav 3:27-38. 2004
    ..Therefore, the experience has substantial consequences on the behavior, mainly by reducing exploratory activity, and the previous experience of the animals has always to be considered in the analysis of genetically modified mice...
  2. ncbi Ain't misbehavin' ? Genotype-environment interactions and the genetics of behavior
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Trends Genet 23:311-4. 2007
    ..This report, together with studies from Drosophila, stresses the importance of understanding genotype-environment interactions...
  3. pmc Caenorhabditis elegans behavioral genetics: where are the knobs?
    Leon Avery
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    BMC Biol 8:69. 2010
    ..I suggest a set of criteria by which some genes important in the evolution of behavior might be recognized, and identify neuropeptide signaling pathways as candidates...
  4. doi Behavioral genetics in antisocial spectrum disorders and psychopathy: a review of the recent literature
    Tracy D Gunter
    Associate Professor, Saint Louis University Department of Neurology and Psychiatry, 1438 S Grand Blvd, St Louis, MO 63104, USA
    Behav Sci Law 28:148-73. 2010
    ..While there is a substantial body of research concerning antisocial spectrum disorders in the behavioral genetics literature, only a few studies could be located using the phenotype of psychopathy...
  5. ncbi Mouse models of autism spectrum disorders: the challenge for behavioral genetics
    Sheryl S Moy
    Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Med Genet C Semin Med Genet 142:40-51. 2006
    ..Research focusing on genes that mediate social behavior in mice may help identify neural circuitry essential for normal social interaction, and lead to novel genetic animal models of the autism behavioral phenotype...
  6. pmc Behavioral genetics and child temperament
    Kimberly J Saudino
    Psychology Department, Boston University, Boston, Massachusetts 02215, USA
    J Dev Behav Pediatr 26:214-23. 2005
    ..However, behavioral genetics has much more to offer to the study of temperament than simple heritability estimates...
  7. ncbi The varieties of selectional experience in behavioral genetics
    Ralph J Greenspan
    The Neurosciences Institute, San Diego, CA 92121, USA
    J Neurogenet 17:241-70. 2003
  8. ncbi Variance components models for gene-environment interaction in twin analysis
    Shaun Purcell
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK
    Twin Res 5:554-71. 2002
    ..As well as elucidating environmental pathways, consideration of gene-environment interaction in quantitative and molecular studies will potentially direct and enhance gene-mapping efforts...
  9. ncbi Likelihood ratio tests in behavioral genetics: problems and solutions
    Annica Dominicus
    Department of Mathematics, Stockholm University, Stockholm, Sweden
    Behav Genet 36:331-40. 2006
    ..Similar results for tests of the AE, DE and E models against the ADE model are also derived. Failing to use the appropriate reference distribution can lead to invalid conclusions...
  10. ncbi Quantitative genetic analyses of complex behaviours in Drosophila
    Robert R H Anholt
    Department of Zoology, W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Nat Rev Genet 5:838-49. 2004
    ..Recent advances in quantitative genetic and functional genomic approaches now enable the extensive characterization of complex genetic networks that mediate behaviours in this important model organism...
  11. doi From gene to aggressive behavior: the role of brain serotonin
    N K Popova
    Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 10 Lavrent ev Prospekt, Novosibirsk, Russia
    Neurosci Behav Physiol 38:471-5. 2008
    ....
  12. ncbi Behavioral genetics of food intake regulation in free-living humans
    J M de Castro
    Department of Psychology, Georgia State University, Atlanta 30303, USA
    Nutrition 15:550-4. 1999
    ....
  13. ncbi Zebra fish: an uncharted behavior genetic model
    Robert Gerlai
    Dept of Psychology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, ON L5L 1C6, Canada
    Behav Genet 33:461-8. 2003
    ....
  14. pmc Evidence for positive selection and population structure at the human MAO-A gene
    Yoav Gilad
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 99:862-7. 2002
    ....
  15. ncbi Advances in behavioral genetics: mouse models of autism
    S S Moy
    Neurodevelopmental Disorders Research Center, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Psychiatry 13:4-26. 2008
    ..Research focusing on the effect of gene-by-gene interactions or genetic susceptibility to detrimental environmental challenges may further understanding of the complex etiology for autism...
  16. ncbi Variance components models for gene-environment interaction in quantitative trait locus linkage analysis
    Shaun Purcell
    Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK
    Twin Res 5:572-6. 2002
    ..As well as elucidating environmental pathways, consideration of G x E in quantitative and molecular studies will potentially direct and enhance gene-mapping efforts...
  17. ncbi Behavioral genetics of Drosophila ananassae
    Shree Ram Singh
    Institute of Evolution, University of Haifa, Mount Carmel, 31905, Haifa, Israel
    Genet Mol Res 2:394-409. 2003
    ..The occurrence of size assortative mating further indicates that there is size-dependent sexual selection in D. ananassae...
  18. ncbi Ethical issues in conducting behavioral genetics research: the case of smoking prevention trials among adolescents
    Benjamin S Wilfond
    Bioethics Research Section, Medical Genetics Branch, National Human Genome Research Institute, USA
    J Health Care Law Policy 6:73-88. 2002
  19. ncbi Cholesky problems
    Gregory Carey
    Department of Psychology and Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0345, USA
    Behav Genet 35:653-65. 2005
    ..constrains the numerical area of search and compromises the maximum likelihood theory currently used in behavioral genetics. Until the reasons for this phenomenon are understood and satisfactory solutions are developed, those who ..
  20. ncbi Analysis of quantitative trait loci that influence animal behavior
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    J Neurobiol 54:46-77. 2003
    ..With advances in multivariate analyses, mapping can also test hypotheses about the psychological processes that give rise to behavioral variation...
  21. pmc Behavioral genetics '97: ASHG statement. Recent developments in human behavioral genetics: past accomplishments and future directions
    S L Sherman
    Department of Genetics, Emory University, Atlanta, GA, USA
    Am J Hum Genet 60:1265-75. 1997
    The field of behavioral genetics has enormous potential to uncover both genetic and environmental influences on normal and deviant behavior...
  22. pmc Canine behavioral genetics: pointing out the phenotypes and herding up the genes
    Tyrone C Spady
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 82:10-8. 2008
    ..Finally, we discuss the applicability of studies of canine behavior to human genetics...
  23. ncbi Opportunities to discover genes regulating depression and antidepressant response from rodent behavioral genetics
    James J Crowley
    Department of Psychiatry, University of Pennsylvania, 538 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Curr Pharm Des 11:157-69. 2005
    ..This paper reviews several of these rodent strains and illustrates the genetic strategies available to discover the long-sought susceptibility genes regulating these phenotypes...
  24. ncbi 'Am not I a fly like thee?' From genes in fruit flies to behavior in humans
    Ralph J Greenspan
    The Neurosciences Institute, San Diego, CA 92118, USA
    Hum Mol Genet 13:R267-73. 2004
    ..Studies of naturally occurring genetic variation in behavior have advanced our understanding of what kinds of variants arise spontaneously and contribute to behavior...
  25. doi Applying mouse complex-trait resources to behavioural genetics
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Nature 456:724-7. 2008
    ..Using these resources, scientists will be able to analyse mouse behaviour at an unprecedented level of detail. Interpreting the new data, however, will require a shift in focus from gene-based approaches to network-based approaches...
  26. ncbi Single-locus control of saccharin preference in mice
    J L Fuller
    J Hered 65:33-6. 1974
  27. ncbi The use of behavioral test batteries, II: effect of test interval
    Richard Paylor
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Physiol Behav 87:95-102. 2006
    ..Thus, it is possible with the current test battery to reduce the inter-test interval to facilitate the rate of studying and identifying behavioral phenotypes in mice...
  28. ncbi An analysis of the genetics of alcohol intoxication in inbred mice
    John C Crabbe
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, and VA Medical Center R and D 12, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Neurosci Biobehav Rev 28:785-802. 2005
    ..This caveat likely extends to many behavioral domains (e.g. learning and memory, anxiety)...
  29. ncbi Different data from different labs: lessons from studies of gene-environment interaction
    Douglas Wahlsten
    Centre for Neuroscience and Department of Psychology, University of Alberta, Edmonton, AB T6G 2E9, Canada
    J Neurobiol 54:283-311. 2003
    ..Implications for behavioral screening of targeted and induced mutations in mice are discussed...
  30. ncbi The psychogenetically selected Roman rat lines differ in the susceptibility to develop amphetamine sensitization
    Maria G Corda
    Department of Toxicology, University of Cagliari, Via Ospedale, 72, 09124 Cagliari, Italy
    Behav Brain Res 157:147-56. 2005
    ....
  31. ncbi Prenatal programming of behavior: a twin-study perspective
    Richard J Rose
    Department of Psychology, Indiana University, Room 132, Psychology Bldg, 1101 East Tenth Street, Bloomington, IN 47405, USA
    Neurosci Biobehav Rev 29:321-7. 2005
    ..Twin comparisons, especially the comparisons of monozygotic co-twins, offer an informative and incisive approach for research on prenatal programming in humans...
  32. ncbi Functional genomics of neural and behavioral plasticity
    Hans A Hofmann
    Harvard University, Bauer Center for Genomics Research, 7 Divinity Ave, Cambridge, Massachusetts 02138, USA
    J Neurobiol 54:272-82. 2003
    ....
  33. ncbi Inter-individual vs line/strain differences in psychogenetically selected Roman High-(RHA) and Low-(RLA) Avoidance rats: neuroendocrine and behavioural aspects
    Thierry Steimer
    Unite de psychopharmacologie clinique, APSIC, Hopitaux Universitaires de Geneve HUG, 2, Ch du petit Bel Air, CH 1225 Chêne Bourg GE, Switzerland
    Neurosci Biobehav Rev 29:99-112. 2005
    ..Within each category (including those which can be obtained by psychogenetic selection), more individual personality traits can evolve, notably as a result of social interactions and particular life events...
  34. ncbi Contrasting grooming phenotypes in three mouse strains markedly different in anxiety and activity (129S1, BALB/c and NMRI)
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
    Behav Brain Res 160:1-10. 2005
    ..We suggest that ethological analysis of mouse grooming, such as that reported here, may be a useful tool in neurobehavioural research...
  35. ncbi Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2
    R M J Deacon
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Physiol Behav 87:723-33. 2006
    ..However, according to the widespread expression of K(ATP) channels, these effects are complex, being dependent on details of test apparatus, procedure and prior experience...
  36. ncbi Deviant peer affiliation and problem behavior: a test of genetic and environmental influences
    Bernadette Marie Bullock
    Child and Family Center, University of Oregon, Eugene, 97401, USA
    J Abnorm Child Psychol 34:29-41. 2006
    ..Parameter estimates differed by rater and method, however. Results accentuate the imperative to attend to method effects inherent in MTMM behavioral geneticresearch...
  37. ncbi An exploratory factor analysis of the Tail Suspension Test in 12 inbred strains of mice and an F2 intercross
    Xiaoqing Liu
    Department of Psychiatry, University of Texas Southwestern Medical Center, NC6 530, 5323, Harry Hines Blvd, Dallas, TX 75390 9070, USA
    Brain Res Bull 60:223-31. 2003
    ..The results support a distinction between "stress reactivity" as measured by the TST and "exploratory fear" behavior as measured by the LDT and OFT...
  38. ncbi Behavioral phenotyping of rodents
    Jacqueline N Crawley
    Section on Behavioral Genomics, Intramural Research Program, National Institute of Mental Health, Building 10 Room 4D11, Bethesda, Maryland, USA
    Comp Med 53:140-6. 2003
    ..A rigorous six-tiered behavioral phenotyping strategy is described. Recommendations are offered for the design of mouse behavioral testing suites in animal housing facilities...
  39. ncbi A behavioural characterisation of the FVB/N mouse strain
    Perdita L Pugh
    Neurology and GI CEDD, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK
    Behav Brain Res 155:283-9. 2004
    ..These data also indicate that the FVB/N strain is not appropriate as a background strain in the behavioural assessment of transgenic mouse models...
  40. ncbi Advances in behavioral genetics modeling using Mplus: applications of factor mixture modeling to twin data
    Bengt Muthen
    Graduate School of Education and Information Studies, University of California, Los Angeles, 90095, USA
    Twin Res Hum Genet 9:313-24. 2006
    ..The factor mixture approach appears to have great potential for the genetic analyses of heterogeneous populations. Generalizations for longitudinal data are also outlined...
  41. ncbi The genetic and environmental basis of the relationship between schizotypy and personality: a twin study
    Kerry L Jang
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Nerv Ment Dis 193:153-9. 2005
    ..Environmental factors appear to be unique to each measure. On the basis of these findings, it is suggested that the environment mediates change in personality function to psychosis as proposed by Meehl's original concept of schizotaxia...
  42. ncbi Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screen
    R Lalonde
    Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, IFRMP23, Bâtiment de Recherche, 76183 Rouen Cedex, France
    Behav Brain Res 157:91-8. 2005
    ..Despite the neurologic signs, APP23 transgenic mice were not deficient in stationary beam, coat-hanger, and rotorod tests, indicating intact motor coordination abilities...
  43. ncbi Behavioural profiles of inbred mouse strains used as transgenic backgrounds. II: cognitive tests
    S P Brooks
    School of Biosciences, Cardiff University, and UWCM, Cardiff, UK
    Genes Brain Behav 4:307-17. 2005
    ....
  44. ncbi Genetic variation in heroin-induced changes in behaviour: effects of B6 strain dose on conditioned reward and locomotor sensitization in 129-B6 hybrid mice
    K K Szumlinski
    Department of Physiology and Neuroscience, and Department of Psychiatry and Behavioral Sciences, Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, SC, USA
    Genes Brain Behav 4:324-36. 2005
    ..Thus, strain differences in heroin responsiveness should be considered when examining transgenic lines on B6-129 backgrounds for opiate-induced changes in behaviour that may be relevant for addiction...
  45. ncbi Behavioral characteristics of rats predisposed to learned helplessness: reduced reward sensitivity, increased novelty seeking, and persistent fear memories
    Jason Shumake
    University of Texas at Austin, Department of Psychology, 1 University Station A8000, Austin, TX 78712 0187, USA
    Behav Brain Res 164:222-30. 2005
    ..This behavioral phenotype is discussed as resembling the personality of humans vulnerable to post-traumatic stress disorder...
  46. ncbi A behavioral genetic study of the overlap between personality and parenting
    Frank M Spinath
    Department of Psychology, University of Bielefeld, Germany
    J Pers 71:785-808. 2003
    ..Results also indicated that the moderate phenotypic covariation between personality and parenting was attributed largely to nongenetic factors. Implications of the findings for research on parenting and personality are considered...
  47. ncbi The fallacy of behavioral phenotyping without standardisation
    F J van der Staay
    Cognitive Neurobiology, Institute for Anatomy II, University of Koln, Joseph Stelzmann Str, Cologne, Germany
    Genes Brain Behav 1:9-13. 2002
    ..Once mutation-induced behavioral changes have been identified, phenotyping of mouse mutants should be performed along a systematic trajectory, which allows for an in-depth characterisation of the mutant under investigation...
  48. ncbi Behavioral phenotyping enhanced--beyond (environmental) standardization
    H Würbel
    Institute of Laboratory Animal Science, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Genes Brain Behav 1:3-8. 2002
    ....
  49. ncbi Tilting at Twindmills: rethinking sociological responses to behavioral genetics
    Jeremy Freese
    Department of Sociology, University of Wisconsin Madison, 1180 Observatory Drive, Madison, WI 53711, USA
    J Health Soc Behav 44:130-5. 2003
    While we commend Horwitz et al. (2003) for speaking to core issues in behavioral genetics, we disagree with many particulars of their article...
  50. ncbi Rethinking twins and environments: possible social sources for assumed genetic influences in twin research
    Allan V Horwitz
    Institute for Health, Health Care Policy, and Aging Research, 30 College Ave, Rutgers University, New Brunswick, N J 08901 1293, USA
    J Health Soc Behav 44:111-29. 2003
    ..These findings suggest that past twin studies could overstate the strength of genetic influences because some similarities in behavior among monozygotic compared to dizygotic twins stem from social influences...
  51. ncbi Genetic linkage mapping of quantitative trait loci for behavioral and neuroendocrine stress response traits in pigs
    C Désautés
    Institut National de la Recherche Agronomique, Laboratoire de Neurogénétique et Stress, Institut Francois Magendie, Bordeaux, France
    J Anim Sci 80:2276-85. 2002
    ..Considering the effects of stress neuroendocrine systems on energy fluxes and protein deposition, and the importance of stress reactivity for meat quality and animal welfare, these results open new perspectives for pig selection...
  52. ncbi Apomorphine susceptibility and animal models for psychopathology: genes and environment
    Bart A Ellenbroek
    Department of Psychoneuropharmacology, HB Nijmegen, The Netherlands
    Behav Genet 32:349-61. 2002
    ..Because schizophrenia is also likely to result from an interaction between genetic and early stressful life events, the APO-SUS rat might represent a promising animal model for studying this severe mental disorder...
  53. ncbi The Japanese Study of Adult Twins Reared Apart and Growing Old Separately
    Kazuo Hayakawa
    Department of Health Promotion Science, Faculty of Medicine, Osaka University, 1 7 Yamadaoka, Suita City, Osaka Fu, Japan
    Twin Res Hum Genet 9:806-7. 2006
    ....
  54. ncbi Registry of adolescent and young adult twins in the Tokyo area
    Chizuru Shikishima
    Department of Human Sciences, Faculty of Letters, Keio University, Japan
    Twin Res Hum Genet 9:811-6. 2006
    ..Adding an evolutionary psychology perspective to the behavior genetics framework is currently being attempted in order to develop a grand theory of human genetics...
  55. ncbi The Michigan State University Twin Registry (MSUTR): genetic, environmental and neurobiological influences on behavior across development
    Kelly L Klump
    Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
    Twin Res Hum Genet 9:971-7. 2006
    ..To date, we have collected data on over 1000 twins, with additional data collections underway. This article provides an overview of the newly developed MSUTR and describes current and future research directions...
  56. ncbi A comparison of the behavior of C57BL/6 and C57BL/10 mice
    R M J Deacon
    Department of Experimental Psychology, University of Oxford, Oxford, UK
    Behav Brain Res 179:239-47. 2007
    ..Consequently, B6 mice will probably remain the preferred choice for behavioral studies. Interpretation of results derived from the B10 strain should take into account its particular behavioral characteristics...
  57. ncbi Future contributions on genetics
    Marie Odile Krebs
    INSERM E0117 Paris V, Universite Rene Descartes, Paris Hôpital Sainte Anne, 7 rue Cabanis, 75014 Paris, France
    World J Biol Psychiatry 6:49-55. 2005
    ..In this non-exhaustive review, we propose an overview from the initial evidence to the expected future, through a critical statement on the current situation...
  58. ncbi Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men
    M J H Kas
    Department of Pharmacology and Anatomy, Behavioural Genomics Section, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Mol Psychiatry 12:324-30. 2007
    ....
  59. ncbi Testing of SHIRPA, a mouse phenotypic assessment protocol, on Dmd(mdx) and Dmd(mdx3cv) dystrophin-deficient mice
    J A Rafael
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Mamm Genome 11:725-8. 2000
    ..These data suggest that the SHIRPA primary screen is effective not only in identifying subtle neuromuscular mutants, but also in distinguishing qualitative differences between mutants with neuromuscular abnormalities...
  60. ncbi Effects of social crowding on emotionality and expression of hippocampal nociceptin/orphanin FQ system transcripts in mice
    D Reiss
    ICS, 1 rue Laurent Fries, BP 10142, 67404 Illkirch, France
    Behav Brain Res 184:167-73. 2007
    ..The possible involvement of central nociceptin mechanisms in behavioural resilience to social crowding stress is discussed...
  61. ncbi Genetics of mouse behavior: interactions with laboratory environment
    J C Crabbe
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97201, USA
    Science 284:1670-2. 1999
    ..For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory...
  62. ncbi Genetic determinants of emotionality and stress response in AcB/BcA recombinant congenic mice and in silico evidence of convergence with cardiovascular candidate genes
    Stéphane Thifault
    Centre de Recherche, Centre hospitalier de l Université de Montréal Technopôle Angus, Montreal, Quebec, Canada
    Hum Mol Genet 17:331-44. 2008
    ..Functional polymorphisms in regulatory elements of candidate genes of the CV/inflammatory/immune systems support the hypothesis of genetically-altered environmental susceptibility in CV disease development...
  63. ncbi The geographic selection mosaic for ponderosa pine and crossbills: a tale of two squirrels
    Thomas L Parchman
    Department of Biology, MSC 3AF, New Mexico State University, Las Cruces, New Mexico 88003, USA
    Evolution 62:348-60. 2008
    ....
  64. ncbi Feeling anxious: a twin study of panic/somatic ratings, anxiety sensitivity and heartbeat perception in children
    Thalia C Eley
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Child Psychol Psychiatry 48:1184-91. 2007
    ..We examined genetic and environmental influences on childhood AS, HBP, panic/somatic ratings, and their associations...
  65. ncbi Longitudinal genetic analysis for loneliness in Dutch twins
    Dorret I Boomsma
    Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
    Twin Res Hum Genet 10:267-73. 2007
    ..Heritability for individual differences in the intercept was estimated at 77%. For the item 'Nobody loves me' no significant trend over age was seen; the heritability of the intercept was estimated at 70%...
  66. ncbi Gene differences influencing visual system function and behavior
    J P Hegmann
    Behav Genet 4:165-70. 1974
  67. pmc The next challenge for psychiatric genetics: characterizing the risk associated with identified genes
    Danielle M Dick
    Washington University in St Louis, Department of Psychology, St Louis, Missouri 63110, USA
    Ann Clin Psychiatry 18:223-31. 2006
    ....
  68. ncbi Influence of paternal genotypes on F1 behaviors: lessons from several mouse strains
    Allan V Kalueff
    Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
    Behav Brain Res 177:45-50. 2007
    ..Our results imply complex interplay between parental genotypes in anxiety, activity, grooming, aggression and barbering of their F1 progeny, further confirming the utility of F1 hybrids in behavioral neurogenetics...
  69. ncbi Gene-environment interactions differentially affect mouse strain behavioral parameters
    Valter Tucci
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire, OX11 0RD, UK
    Mamm Genome 17:1113-20. 2006
    ..Further investigations into the extent and limits of genetic and environmental variables are critical for the realization of both behavioral and functional genomics endpoints...
  70. pmc A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen
    Leon G Reijmers
    Institute for Childhood and Neglected Diseases, Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Learn Mem 13:143-9. 2006
    ..Mapping of Slowlearner found linkage to a region of chromosome 12 (LOD score of 6.5 close to D12Mit171), which suggests that ENU mutants should enable the positional cloning of genes involved in memory formation...
  71. ncbi Wistar rats with high versus low rearing activity differ in radial maze performance
    Jutta Görisch
    Experimental and Physiological Psychology, Philipps University of Marburg, Gutenbergstr 18, 35032 Marburg, Germany
    Neurobiol Learn Mem 86:175-87. 2006
    ..These results are discussed with respect to the role of cognitive and motivational mechanisms, which as subject-inherent factors can contribute substantially to inter-individual variability in the radial maze...
  72. ncbi A hitchhiker's guide to behavioral analysis in laboratory rodents
    N Sousa
    Neuroscience Group, Life and Health Science Research Institute ICVS, Health Science School, University of Minho, Braga, Portugal
    Genes Brain Behav 5:5-24. 2006
    Genes and environment are both essential and interdependent determinants of behavioral responses. Behavioral genetics focuses on the role of genes on behavior...
  73. ncbi Intra- and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controls
    Gary W Arendash
    Memory and Aging Research Laboratory, Department of Biology, University of South Florida, Tampa, FL 33620, USA
    Physiol Behav 75:643-52. 2002
    ....
  74. ncbi The mixed or multilevel model for behavior genetic analysis
    Guang Guo
    Department of Sociology, University of North Carolina at Chapel Hill, 27599, USA
    Behav Genet 32:37-49. 2002
    ..We compare results from the mixed or multilevel model, Pearson's correlation analysis, and the structural equation model...
  75. ncbi Combined application of behavior genetics and microarray analysis to identify regional expression themes and gene-behavior associations
    Noah E Letwin
    Department of Functional Genomics, The Institute for Genomic Research, Rockville, Maryland 20850, USA
    J Neurosci 26:5277-87. 2006
    ..The approaches and data set described herein serve as a valuable resource to investigate the genetic underpinning of complex behaviors...
  76. ncbi Is the genetic structure of human personality universal? A cross-cultural twin study from North America, Europe, and Asia
    Shinji Yamagata
    Department of Cognitive and Behavioral Science, Graduate School of Arts and Sciences, University of Tokyo, Japan
    J Pers Soc Psychol 90:987-98. 2006
    ..These results suggest that the FFM has a solid biological basis and may represent a common heritage of the human species...
  77. ncbi Wild mouse open field behavior is embedded within the multidimensional data space spanned by laboratory inbred strains
    E Fonio
    Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Genes Brain Behav 5:380-8. 2006
    ..The implication could be that whereas natural selection favors moderate locomotor behavior in wild mice, the inbreeding process tends to generate in mice, in some of the features, extreme and more variable behavior...
  78. pmc Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains
    Sheryl S Moy
    North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 176:4-20. 2007
    ..Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses...
  79. ncbi Accelerated nervous system development contributes to behavioral efficiency in the laboratory mouse: a behavioral review and theoretical proposal
    I Q Whishaw
    Canadian Center for Behavioral Neuroscience, University of Lethbridge and NeuroDetective Inc, Lethbridge, Alberta, T1K 3M4
    Dev Psychobiol 39:151-70. 2001
    ..Since the mouse's biological adaptations will be reflected in laboratory behavior, suggestions are made for behavioral approaches to the study and interpretation of mouse behavior...
  80. pmc Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype
    Jessica J Nadler
    Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill 27599 7264, USA
    Genetics 174:1229-36. 2006
    ..Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression...
  81. ncbi Behavioural phenotyping of mouse mutants
    F J van der Staay
    Cognitive Neurobiology, Institute for Anatomy II, , Joseph Stelzmann Str. 9, 50931 Cologne, Germany
    Behav Brain Res 125:3-12. 2001
    ..The development and standardisation of sensitive, valid behavioural tests which are suited to phenotype mouse mutants is both a responsibility and a challenge to investigators of mouse behaviour...
  82. ncbi Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains
    Rachel A Millstein
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane, Room 2N09, Rockville, MD 20852, USA
    Neurosci Biobehav Rev 31:3-17. 2007
    ..Data demonstrate that the MS procedure employed does not provide a robust model of early life stress effects on the anxiety- and depression-related behaviors in the mouse strains tested...
  83. ncbi The use of behavioral test batteries: effects of training history
    K L McIlwain
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Physiol Behav 73:705-17. 2001
    ..These two studies demonstrate that some behavioral tests appear to be sensitive to previous testing experience, while other tests are immune...
  84. pmc Genetic fatalism and social policy: the implications of behavior genetics research
    J S Alper
    Department of Chemistry, University of Massachusetts-Boston 02125, USA
    Yale J Biol Med 66:511-24. 1993
    ..between these concepts and the malleability of traits for both molecular and nonmolecular approaches to behavioral genetics. We argue that the malleability of traits is as much a social and political question as it is a biological ..
  85. ncbi Application of proteomics to ecology and population biology
    T L Karr
    Department of Biology and Biochemistry, University of Bath, Bath, UK
    Heredity (Edinb) 100:200-6. 2008
    ..There has been very little application of proteomics to the fields of behavioral genetics, evolution, ecology and population dynamics, and has only recently been effectively applied to the closely ..
  86. doi Altered expression of Autism-associated genes in the brain of Fragile X mouse model
    Aiying Zhang
    Department of Genetics, Peking University Health Science Center, Beijing 100083, China
    Biochem Biophys Res Commun 379:920-3. 2009
    ..J. Nadler, T.R. Magnuson, J.N. Crawley, Mouse models of autism spectrum disorders: the challenge for behavioral genetics, Am. J. Med. Genet. 142 (2006) 40-51]...
  87. pmc How neuroscience and behavioral genetics improve psychiatric assessment: report on a violent murder case
    Davide Rigoni
    Department of Developmental and Socialization Psychology, University of Padua Padua, Italy
    Front Behav Neurosci 4:160. 2010
    ..Here we report on a case in which cognitive neuroscience and behavioral genetics methods were applied to a psychiatric forensic evaluation conducted on a young woman, J.F...
  88. doi The evolution of the cognitive model of depression and its neurobiological correlates
    Aaron T Beck
    Department of Psychiatry, University of Pennsylvania, 3535 Market St, Rm 2032, Philadelphia, PA 19104, USA
    Am J Psychiatry 165:969-77. 2008
    ..Combining findings from behavioral genetics and cognitive neuroscience with the accumulated research on the cognitive model opens new opportunities for ..
  89. ncbi Race and genetics: controversies in biomedical, behavioral, and forensic sciences
    Pilar Ossorio
    Department of Medical History and Bioethics, University of Wisconsin Madison, Madison, WI 53706 1399, USA
    Am Psychol 60:115-28. 2005
    ..The article then discusses 1 context, criminology, in which the use of racial variables in behavioral genetics research could be particularly problematic...
  90. ncbi Short-term selection for the interaction between S-propranolol and ethanol in mice
    Richard A Deitrich
    Department of Pharmacology, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    Alcohol Clin Exp Res 27:1236-40. 2003
    ..Therefore, we carried out a short-term breeding project to determine whether the response could be selectively bred...
  91. pmc Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades
    Douglas Wahlsten
    Department of Psychology, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Proc Natl Acad Sci U S A 103:16364-9. 2006
    ..classical study many years later, will we obtain the same results? Recent research with mice in neural and behavioral genetics yielded different results in different laboratories for certain phenotypes, and these findings suggested to ..
  92. pmc PDK1 and HR46 gene homologs tie social behavior to ovary signals
    Ying Wang
    School of Life Sciences, Arizona State University, Tempe, AZ, USA
    PLoS ONE 4:e4899. 2009
    ..The honey bee is a model for studying evolutionary behavioral genetics because of its well characterized age-correlated division of labor...
  93. ncbi Role of the family in the onset and outcome of childhood disorders: selected research findings
    M Z Wamboldt
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Am Acad Child Adolesc Psychiatry 39:1212-9. 2000
    ..family research were selected for review as being of special importance to the clinically oriented child and adolescent psychiatrist: behavioral genetics, expressed emotion, and the interaction of family dynamics and childhood illness.
  94. pmc Drosophila genetics in the classroom
    W Sofer
    Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08854 0759
    Genetics 136:417-22. 1994
    ..In recent years, the organism has also helped students understand biochemical and behavioral genetics. In this connection, this article describes the development of a set of integrated laboratory exercises and ..
  95. pmc Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure
    Stephanie M Rollmann
    Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Genetics 179:1327-36. 2008
    ..influences variation in brain structures and behavioral phenotypes represents a central challenge in behavioral genetics. In Drosophila melanogaster, the neuralized (neur) gene plays a key role in development of the nervous ..
  96. ncbi Development and modification of child food preferences and eating patterns: behavior genetics strategies
    M S Faith
    University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, PA 19104, USA
    Int J Obes (Lond) 29:549-56. 2005
    b>Behavioral genetics (BG) designs can offer useful strategies for studying the development of child food preferences and eating patterns...
  97. pmc Genetic analysis of sleep
    Amanda Crocker
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 24:1220-35. 2010
    ..In the two decades since, there have been many advances in the field of behavioral genetics, but it is only in the past 10 years that the genetic analysis of sleep has emerged as an important ..
  98. ncbi A logistic regression based extension of the TDT for continuous and categorical traits
    I D Waldman
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Ann Hum Genet 63:329-40. 1999
    ..Given its features, we regard the logistic regression extension of the TDT as a flexible new data analytic method with extensive potential applications to problems in medical, psychiatric, and behavioral genetics.
  99. pmc Serotonin transporter promoter region (5-HTTLPR) polymorphism predicts resting respiratory sinus arrhythmia
    Alissa J Ellis
    Department of Psychology, The University of Texas at Austin, Austin, Texas 78712 0187, USA
    Psychophysiology 48:923-6. 2011
    ..Although behavioral genetics research indicates that RSA is partly heritable, relatively few molecular genetics studies have been ..
  100. doi Influences on child eating and weight development from a behavioral genetics perspective
    Tanja V E Kral
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr Psychol 34:596-605. 2009
    ..The review concludes with an outlook on possibilities for future research efforts in the field...
  101. ncbi Review of twin and family studies on neuroanatomic phenotypes and typical neurodevelopment
    J Eric Schmitt
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
    Twin Res Hum Genet 10:683-94. 2007
    ..At present, the majority of twin imaging studies are limited by sample sizes small by the standards of behavioral genetics; nevertheless the literature at present represents a pioneering effort in the pursuit of answers to many ..

Research Grants83

  1. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2005
    ..b>Behavioral genetics studies have consistently demonstrated significant genetic contributions to individual differences in ..
  2. Force Plate Actometer for Measuring Behavior in Rodents
    Candice Kissinger; Fiscal Year: 2003
    ..which can replace several different instruments, will find application in pharmacology, toxicology, behavioral genetics and behavioral neuroscience...
  3. The Psychobiology of Trauma and Resilience Across the LIfespan
    Dean Kilpatrick; Fiscal Year: 2007
    ..g., behavioral genetics, neuroscience, psychosocial, public health, biological, treatment outcome); 3) failure to consider the ..
  4. Internatl Conf.on the Future of Cognitive Aging Research
    DUANE ALWIN; Fiscal Year: 2005
    ..experts on cognitive aging representing the fields of developmental psychology, psychiatry, neuroscience, behavioral genetics, demography, gerontology, sociology, economics, biostatistics, and epidemiology to gather for a two and one-..
  5. Temperament and Developmental Psychopathology
    David Rettew; Fiscal Year: 2007
    ..additional skills in three areas are identified as Traininq Goals: (1) Temperament assessment, (2) Behavioral genetics, (3) Relationship between temperamant and child psychopathology. Jim Hudziak, M.D. and Thomas Achenbach, Ph...
  6. Genetics of Fear and Anxiety Disorders
    JOHN HETTEMA; Fiscal Year: 2006
    ..Hettema's primary sponsor. The training will take place at the Virginia Institute for Psychiatric and Behavioral Genetics of Virginia Commonwealth University, which provides a rich, stimulating environment for the conduct of ..
  7. NATURE & NURTURE IN SOCIAL DEMOGRAPHY: AN ADOPTION STUDY
    Michael Stallings; Fiscal Year: 2007
    ..The proposed research is innovative, both in the field of behavioral genetics and the field of social demography, in that it brings behavioral genetic methods to bear on social ..
  8. NATURE & NURTURE IN SOCIAL DEMOGRAPHY: AN ADOPTION STUDY
    John DeFries; Fiscal Year: 2002
    ..Significance: The proposed research is innovative, both in the fields of behavioral genetics and in social demography, in that it brings behavioral genetic methods to bear 1) on sociological and ..
  9. Molecular genetics of executive function in dyslexia
    Zoran Brkanac; Fiscal Year: 2007
    ..grant is to help establish the candidate's independent research career in the field of psychiatric and behavioral genetics. The candidate has completed clinical training in psychiatry and child psychiatry, and has prior research ..
  10. BEHAVIORAL GENETICS--MODELS/MECHANISMS OF SCHIZOPHRENIA
    Clinton Kilts; Fiscal Year: 2002
    ..abstract_text> ..
  11. Predoctoral Training in Integrative Neuroscience
    David Anderson; Fiscal Year: 2007
    ..neurons); 3) behavior (simple and complex behaviors in vertebrates, arthropods, and nematodes, including behavioral genetics); 4) computational neuroscience (studies of single neurons, systems of neurons, and whole organisms)...