Genomes and Genes
Summary: The experimental study of the relationship between the genotype of an organism and its behavior. The scope includes the effects of genes on simple sensory processes to complex organization of the nervous system.
Publications200 found, 100 shown here
- Ain't misbehavin' ? Genotype-environment interactions and the genetics of behaviorTrudy F C Mackay
Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
Trends Genet 23:311-4. 2007..This report, together with studies from Drosophila, stresses the importance of understanding genotype-environment interactions...
- Zebra fish: an uncharted behavior genetic modelRobert Gerlai
Dept of Psychology, University of Toronto at Mississauga, 3359 Mississauga Road North, Mississauga, ON L5L 1C6, Canada
Behav Genet 33:461-8. 2003....
- Advances in behavioral genetics: mouse models of autismS S Moy
Neurodevelopmental Disorders Research Center, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Mol Psychiatry 13:4-26. 2008..Research focusing on the effect of gene-by-gene interactions or genetic susceptibility to detrimental environmental challenges may further understanding of the complex etiology for autism...
- From gene to aggressive behavior: the role of brain serotoninN K Popova
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, 10 Lavrent ev Prospekt, Novosibirsk, Russia
Neurosci Behav Physiol 38:471-5. 2008....
- Behavioral genetics of food intake regulation in free-living humansJ M de Castro
Department of Psychology, Georgia State University, Atlanta 30303, USA
Nutrition 15:550-4. 1999....
- Caenorhabditis elegans behavioral genetics: where are the knobs?Leon Avery
Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9148, USA
BMC Biol 8:69. 2010..I suggest a set of criteria by which some genes important in the evolution of behavior might be recognized, and identify neuropeptide signaling pathways as candidates...
- Variance components models for gene-environment interaction in twin analysisShaun Purcell
Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK
Twin Res 5:554-71. 2002..As well as elucidating environmental pathways, consideration of gene-environment interaction in quantitative and molecular studies will potentially direct and enhance gene-mapping efforts...
- Mouse models of autism spectrum disorders: the challenge for behavioral geneticsSheryl S Moy
Neurodevelopmental Disorders Research Center, CB 7146, University of North Carolina, Chapel Hill, NC 27599, USA
Am J Med Genet C Semin Med Genet 142:40-51. 2006..Research focusing on genes that mediate social behavior in mice may help identify neural circuitry essential for normal social interaction, and lead to novel genetic animal models of the autism behavioral phenotype...
- Analysis of quantitative trait loci that influence animal behaviorJonathan Flint
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
J Neurobiol 54:46-77. 2003..With advances in multivariate analyses, mapping can also test hypotheses about the psychological processes that give rise to behavioral variation...
- Variance components models for gene-environment interaction in quantitative trait locus linkage analysisShaun Purcell
Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College, London, UK
Twin Res 5:572-6. 2002..As well as elucidating environmental pathways, consideration of G x E in quantitative and molecular studies will potentially direct and enhance gene-mapping efforts...
- Behavioral genetics of Drosophila ananassaeShree Ram Singh
Institute of Evolution, University of Haifa, Mount Carmel, 31905, Haifa, Israel
Genet Mol Res 2:394-409. 2003..The occurrence of size assortative mating further indicates that there is size-dependent sexual selection in D. ananassae...
- Ethical issues in conducting behavioral genetics research: the case of smoking prevention trials among adolescentsBenjamin S Wilfond
Bioethics Research Section, Medical Genetics Branch, National Human Genome Research Institute, USA
J Health Care Law Policy 6:73-88. 2002
- Cholesky problemsGregory Carey
Department of Psychology and Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0345, USA
Behav Genet 35:653-65. 2005..constrains the numerical area of search and compromises the maximum likelihood theory currently used in behavioral genetics. Until the reasons for this phenomenon are understood and satisfactory solutions are developed, those who ..
- Opportunities to discover genes regulating depression and antidepressant response from rodent behavioral geneticsJames J Crowley
Department of Psychiatry, University of Pennsylvania, 538 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
Curr Pharm Des 11:157-69. 2005..This paper reviews several of these rodent strains and illustrates the genetic strategies available to discover the long-sought susceptibility genes regulating these phenotypes...
- Behavioral genetics '97: ASHG statement. Recent developments in human behavioral genetics: past accomplishments and future directionsS L Sherman
Department of Genetics, Emory University, Atlanta, GA, USA
Am J Hum Genet 60:1265-75. 1997The field of behavioral genetics has enormous potential to uncover both genetic and environmental influences on normal and deviant behavior...
- Single-locus control of saccharin preference in miceJ L Fuller
J Hered 65:33-6. 1974
- Applying mouse complex-trait resources to behavioural geneticsJonathan Flint
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Nature 456:724-7. 2008..Using these resources, scientists will be able to analyse mouse behaviour at an unprecedented level of detail. Interpreting the new data, however, will require a shift in focus from gene-based approaches to network-based approaches...
- Quantitative genetic analyses of complex behaviours in DrosophilaRobert R H Anholt
Department of Zoology, W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
Nat Rev Genet 5:838-49. 2004..Recent advances in quantitative genetic and functional genomic approaches now enable the extensive characterization of complex genetic networks that mediate behaviours in this important model organism...
- Canine behavioral genetics: pointing out the phenotypes and herding up the genesTyrone C Spady
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Hum Genet 82:10-8. 2008..Finally, we discuss the applicability of studies of canine behavior to human genetics...
- Likelihood ratio tests in behavioral genetics: problems and solutionsAnnica Dominicus
Department of Mathematics, Stockholm University, Stockholm, Sweden
Behav Genet 36:331-40. 2006..Similar results for tests of the AE, DE and E models against the ADE model are also derived. Failing to use the appropriate reference distribution can lead to invalid conclusions...
- 'Am not I a fly like thee?' From genes in fruit flies to behavior in humansRalph J Greenspan
The Neurosciences Institute, San Diego, CA 92118, USA
Hum Mol Genet 13:R267-73. 2004..Studies of naturally occurring genetic variation in behavior have advanced our understanding of what kinds of variants arise spontaneously and contribute to behavior...
- Intra- and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controlsGary W Arendash
Memory and Aging Research Laboratory, Department of Biology, University of South Florida, Tampa, FL 33620, USA
Physiol Behav 75:643-52. 2002....
- Contrasting grooming phenotypes in three mouse strains markedly different in anxiety and activity (129S1, BALB/c and NMRI)Allan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere 33014, Finland
Behav Brain Res 160:1-10. 2005..We suggest that ethological analysis of mouse grooming, such as that reported here, may be a useful tool in neurobehavioural research...
- Behavioural profiles of inbred mouse strains used as transgenic backgrounds. II: cognitive testsS P Brooks
School of Biosciences, Cardiff University, and UWCM, Cardiff, UK
Genes Brain Behav 4:307-17. 2005....
- Different data from different labs: lessons from studies of gene-environment interactionDouglas Wahlsten
Centre for Neuroscience and Department of Psychology, University of Alberta, Edmonton, AB T6G 2E9, Canada
J Neurobiol 54:283-311. 2003..Implications for behavioral screening of targeted and induced mutations in mice are discussed...
- Functional genomics of neural and behavioral plasticityHans A Hofmann
Harvard University, Bauer Center for Genomics Research, 7 Divinity Ave, Cambridge, Massachusetts 02138, USA
J Neurobiol 54:272-82. 2003....
- Genetic variation in heroin-induced changes in behaviour: effects of B6 strain dose on conditioned reward and locomotor sensitization in 129-B6 hybrid miceK K Szumlinski
Department of Physiology and Neuroscience, and Department of Psychiatry and Behavioral Sciences, Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, SC, USA
Genes Brain Behav 4:324-36. 2005..Thus, strain differences in heroin responsiveness should be considered when examining transgenic lines on B6-129 backgrounds for opiate-induced changes in behaviour that may be relevant for addiction...
- Behavioral characteristics of rats predisposed to learned helplessness: reduced reward sensitivity, increased novelty seeking, and persistent fear memoriesJason Shumake
University of Texas at Austin, Department of Psychology, 1 University Station A8000, Austin, TX 78712-0187, USA
Behav Brain Res 164:222-30. 2005..This behavioral phenotype is discussed as resembling the personality of humans vulnerable to post-traumatic stress disorder...
- Apomorphine susceptibility and animal models for psychopathology: genes and environmentBart A Ellenbroek
Department of Psychoneuropharmacology, HB Nijmegen, The Netherlands
Behav Genet 32:349-61. 2002..Because schizophrenia is also likely to result from an interaction between genetic and early stressful life events, the APO-SUS rat might represent a promising animal model for studying this severe mental disorder...
- Genetic linkage mapping of quantitative trait loci for behavioral and neuroendocrine stress response traits in pigsC Désautés
Institut National de la Recherche Agronomique, Laboratoire de Neurogénétique et Stress, Institut Francois Magendie, Bordeaux, France
J Anim Sci 80:2276-85. 2002..Considering the effects of stress neuroendocrine systems on energy fluxes and protein deposition, and the importance of stress reactivity for meat quality and animal welfare, these results open new perspectives for pig selection...
- The use of behavioral test batteries, II: effect of test intervalRichard Paylor
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Physiol Behav 87:95-102. 2006..Thus, it is possible with the current test battery to reduce the inter-test interval to facilitate the rate of studying and identifying behavioral phenotypes in mice...
- Prenatal programming of behavior: a twin-study perspectiveRichard J Rose
Department of Psychology, Indiana University, Room 132, Psychology Bldg, 1101 East Tenth Street, Bloomington, IN 47405, USA
Neurosci Biobehav Rev 29:321-7. 2005..Twin comparisons, especially the comparisons of monozygotic co-twins, offer an informative and incisive approach for research on prenatal programming in humans...
- A behavioural characterisation of the FVB/N mouse strainPerdita L Pugh
Neurology and GI CEDD, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK
Behav Brain Res 155:283-9. 2004..These data also indicate that the FVB/N strain is not appropriate as a background strain in the behavioural assessment of transgenic mouse models...
- The psychogenetically selected Roman rat lines differ in the susceptibility to develop amphetamine sensitizationMaria G Corda
Department of Toxicology, University of Cagliari, Via Ospedale, 72, 09124 Cagliari, Italy
Behav Brain Res 157:147-56. 2005....
- An analysis of the genetics of alcohol intoxication in inbred miceJohn C Crabbe
Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, and VA Medical Center R and D 12, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
Neurosci Biobehav Rev 28:785-802. 2005..This caveat likely extends to many behavioral domains (e.g. learning and memory, anxiety)...
- Behavioral alterations induced by repeated testing in C57BL/6J and 129S2/Sv mice: implications for phenotyping screensV Voikar
Neuroscience Center and Department of Biosciences, University of Helsinki, Finland
Genes Brain Behav 3:27-38. 2004..Therefore, the experience has substantial consequences on the behavior, mainly by reducing exploratory activity, and the previous experience of the animals has always to be considered in the analysis of genetically modified mice...
- Inter-individual vs line/strain differences in psychogenetically selected Roman High-(RHA) and Low-(RLA) Avoidance rats: neuroendocrine and behavioural aspectsThierry Steimer
Unite de psychopharmacologie clinique, APSIC, Hopitaux Universitaires de Geneve HUG, 2, Ch du petit Bel Air, CH 1225 Chêne Bourg GE, Switzerland
Neurosci Biobehav Rev 29:99-112. 2005..Within each category (including those which can be obtained by psychogenetic selection), more individual personality traits can evolve, notably as a result of social interactions and particular life events...
- The genetic and environmental basis of the relationship between schizotypy and personality: a twin studyKerry L Jang
Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
J Nerv Ment Dis 193:153-9. 2005..Environmental factors appear to be unique to each measure. On the basis of these findings, it is suggested that the environment mediates change in personality function to psychosis as proposed by Meehl's original concept of schizotaxia...
- A behavioral genetic study of the overlap between personality and parentingFrank M Spinath
Department of Psychology, University of Bielefeld, Germany
J Pers 71:785-808. 2003..Results also indicated that the moderate phenotypic covariation between personality and parenting was attributed largely to nongenetic factors. Implications of the findings for research on parenting and personality are considered...
- The fallacy of behavioral phenotyping without standardisationF J van der Staay
Cognitive Neurobiology, Institute for Anatomy II, , Joseph Stelzmann Str, Cologne, Germany
Genes Brain Behav 1:9-13. 2002..Once mutation-induced behavioral changes have been identified, phenotyping of mouse mutants should be performed along a systematic trajectory, which allows for an in-depth characterisation of the mutant under investigation...
- Behavioral phenotyping enhanced--beyond (environmental) standardizationH Würbel
Institute of Laboratory Animal Science, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Genes Brain Behav 1:3-8. 2002....
- Tilting at Twindmills: rethinking sociological responses to behavioral geneticsJeremy Freese
Department of Sociology, University of Wisconsin Madison, 1180 Observatory Drive, Madison, WI 53711, USA
J Health Soc Behav 44:130-5. 2003While we commend Horwitz et al. (2003) for speaking to core issues in behavioral genetics, we disagree with many particulars of their article...
- Rethinking twins and environments: possible social sources for assumed genetic influences in twin researchAllan V Horwitz
Institute for Health, Health Care Policy, and Aging Research, 30 College Ave, Rutgers University, New Brunswick, N J 08901 1293, USA
J Health Soc Behav 44:111-29. 2003..These findings suggest that past twin studies could overstate the strength of genetic influences because some similarities in behavior among monozygotic compared to dizygotic twins stem from social influences...
- Behavioral phenotyping of rodentsJacqueline N Crawley
Section on Behavioral Genomics, Intramural Research Program, National Institute of Mental Health, Building 10 Room 4D11, Bethesda, Maryland, USA
Comp Med 53:140-6. 2003..A rigorous six-tiered behavioral phenotyping strategy is described. Recommendations are offered for the design of mouse behavioral testing suites in animal housing facilities...
- An exploratory factor analysis of the Tail Suspension Test in 12 inbred strains of mice and an F2 intercrossXiaoqing Liu
Department of Psychiatry, University of Texas Southwestern Medical Center, NC6.530, 5323, Harry Hines Blvd, Dallas, TX 75390-9070, USA
Brain Res Bull 60:223-31. 2003..The results support a distinction between "stress reactivity" as measured by the TST and "exploratory fear" behavior as measured by the LDT and OFT...
- Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screenR Lalonde
Universite de Rouen, Faculte de Medecine et de Pharmacie, INSERM U614, IFRMP23, Bâtiment de Recherche, 76183 Rouen Cedex, France
Behav Brain Res 157:91-8. 2005..Despite the neurologic signs, APP23 transgenic mice were not deficient in stationary beam, coat-hanger, and rotorod tests, indicating intact motor coordination abilities...
- The mixed or multilevel model for behavior genetic analysisGuang Guo
Department of Sociology, University of North Carolina at Chapel Hill, 27599, USA
Behav Genet 32:37-49. 2002..We compare results from the mixed or multilevel model, Pearson's correlation analysis, and the structural equation model...
- Future contributions on geneticsMarie Odile Krebs
INSERM E0117 Paris V, Universite Rene Descartes, Paris Hôpital Sainte Anne, 7 rue Cabanis, 75014 Paris, France
World J Biol Psychiatry 6:49-55. 2005..In this non-exhaustive review, we propose an overview from the initial evidence to the expected future, through a critical statement on the current situation...
- Testing of SHIRPA, a mouse phenotypic assessment protocol, on Dmd(mdx) and Dmd(mdx3cv) dystrophin-deficient miceJ A Rafael
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Mamm Genome 11:725-8. 2000..These data suggest that the SHIRPA primary screen is effective not only in identifying subtle neuromuscular mutants, but also in distinguishing qualitative differences between mutants with neuromuscular abnormalities...
- The next challenge for psychiatric genetics: characterizing the risk associated with identified genesDanielle M Dick
Washington University in St Louis, Department of Psychology, St Louis, Missouri 63110, USA
Ann Clin Psychiatry 18:223-31. 2006....
- The Japanese Study of Adult Twins Reared Apart and Growing Old SeparatelyKazuo Hayakawa
Department of Health Promotion Science, Faculty of Medicine, Osaka University, 1 7 Yamadaoka, Suita City, Osaka Fu, Japan
Twin Res Hum Genet 9:806-7. 2006....
- Registry of adolescent and young adult twins in the Tokyo areaChizuru Shikishima
Department of Human Sciences, Faculty of Letters, Keio University, Japan
Twin Res Hum Genet 9:811-6. 2006..Adding an evolutionary psychology perspective to the behavior genetics framework is currently being attempted in order to develop a grand theory of human genetics...
- The Michigan State University Twin Registry (MSUTR): genetic, environmental and neurobiological influences on behavior across developmentKelly L Klump
Department of Psychology, Michigan State University, East Lansing, MI 48824, USA
Twin Res Hum Genet 9:971-7. 2006..To date, we have collected data on over 1000 twins, with additional data collections underway. This article provides an overview of the newly developed MSUTR and describes current and future research directions...
- Genetics of mouse behavior: interactions with laboratory environmentJ C Crabbe
Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97201, USA
Science 284:1670-2. 1999..For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory...
- A comparison of the behavior of C57BL/6 and C57BL/10 miceR M J Deacon
Department of Experimental Psychology, University of Oxford, Oxford, UK
Behav Brain Res 179:239-47. 2007..Consequently, B6 mice will probably remain the preferred choice for behavioral studies. Interpretation of results derived from the B10 strain should take into account its particular behavioral characteristics...
- Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and menM J H Kas
Department of Pharmacology and Anatomy, Behavioural Genomics Section, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
Mol Psychiatry 12:324-30. 2007....
- Longitudinal genetic analysis for loneliness in Dutch twinsDorret I Boomsma
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Twin Res Hum Genet 10:267-73. 2007..Heritability for individual differences in the intercept was estimated at 77%. For the item 'Nobody loves me' no significant trend over age was seen; the heritability of the intercept was estimated at 70%...
- Effects of social crowding on emotionality and expression of hippocampal nociceptin/orphanin FQ system transcripts in miceD Reiss
ICS, 1 rue Laurent Fries, BP 10142, 67404 Illkirch, France
Behav Brain Res 184:167-73. 2007..The possible involvement of central nociceptin mechanisms in behavioural resilience to social crowding stress is discussed...
- Genetic determinants of emotionality and stress response in AcB/BcA recombinant congenic mice and in silico evidence of convergence with cardiovascular candidate genesStéphane Thifault
Centre de Recherche, Centre hospitalier de l Université de Montréal Technopôle Angus, Montreal, Quebec, Canada
Hum Mol Genet 17:331-44. 2008..Functional polymorphisms in regulatory elements of candidate genes of the CV/inflammatory/immune systems support the hypothesis of genetically-altered environmental susceptibility in CV disease development...
- The geographic selection mosaic for ponderosa pine and crossbills: a tale of two squirrelsThomas L Parchman
Department of Biology, MSC 3AF, New Mexico State University, Las Cruces, New Mexico 88003, USA
Evolution 62:348-60. 2008....
- Feeling anxious: a twin study of panic/somatic ratings, anxiety sensitivity and heartbeat perception in childrenThalia C Eley
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
J Child Psychol Psychiatry 48:1184-91. 2007..We examined genetic and environmental influences on childhood AS, HBP, panic/somatic ratings, and their associations...
- Influence of paternal genotypes on F1 behaviors: lessons from several mouse strainsAllan V Kalueff
Department of Anatomy, Medical School, University of Tampere, Tampere, Finland
Behav Brain Res 177:45-50. 2007..Our results imply complex interplay between parental genotypes in anxiety, activity, grooming, aggression and barbering of their F1 progeny, further confirming the utility of F1 hybrids in behavioral neurogenetics...
- Gene-environment interactions differentially affect mouse strain behavioral parametersValter Tucci
MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire, OX11 0RD, UK
Mamm Genome 17:1113-20. 2006..Further investigations into the extent and limits of genetic and environmental variables are critical for the realization of both behavioral and functional genomics endpoints...
- Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotypeJessica J Nadler
Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill 27599-7264, USA
Genetics 174:1229-36. 2006..Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression...
- Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2R M J Deacon
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
Physiol Behav 87:723-33. 2006..However, according to the widespread expression of K(ATP) channels, these effects are complex, being dependent on details of test apparatus, procedure and prior experience...
- Deviant peer affiliation and problem behavior: a test of genetic and environmental influencesBernadette Marie Bullock
Child and Family Center, University of Oregon, Eugene, 97401, USA
J Abnorm Child Psychol 34:29-41. 2006..Parameter estimates differed by rater and method, however. Results accentuate the imperative to attend to method effects inherent in MTMM behavioral geneticresearch...
- Accelerated nervous system development contributes to behavioral efficiency in the laboratory mouse: a behavioral review and theoretical proposalI Q Whishaw
Canadian Center for Behavioral Neuroscience, University of Lethbridge and NeuroDetective Inc, Lethbridge, Alberta, T1K 3M4
Dev Psychobiol 39:151-70. 2001..Since the mouse's biological adaptations will be reflected in laboratory behavior, suggestions are made for behavioral approaches to the study and interpretation of mouse behavior...
- Behavioural phenotyping of mouse mutantsF J van der Staay
Cognitive Neurobiology, Institute for Anatomy II, , Joseph Stelzmann Str. 9, 50931 Cologne, Germany
Behav Brain Res 125:3-12. 2001..The development and standardisation of sensitive, valid behavioural tests which are suited to phenotype mouse mutants is both a responsibility and a challenge to investigators of mouse behaviour...
- A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screenLeon G Reijmers
Institute for Childhood and Neglected Diseases, Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Learn Mem 13:143-9. 2006..Mapping of Slowlearner found linkage to a region of chromosome 12 (LOD score of 6.5 close to D12Mit171), which suggests that ENU mutants should enable the positional cloning of genes involved in memory formation...
- Wistar rats with high versus low rearing activity differ in radial maze performanceJutta Görisch
Experimental and Physiological Psychology, Philipps University of Marburg, Gutenbergstr 18, 35032 Marburg, Germany
Neurobiol Learn Mem 86:175-87. 2006..These results are discussed with respect to the role of cognitive and motivational mechanisms, which as subject-inherent factors can contribute substantially to inter-individual variability in the radial maze...
- A hitchhiker's guide to behavioral analysis in laboratory rodentsN Sousa
Neuroscience Group, Life and Health Science Research Institute ICVS, Health Science School, University of Minho, Braga, Portugal
Genes Brain Behav 5:5-24. 2006Genes and environment are both essential and interdependent determinants of behavioral responses. Behavioral genetics focuses on the role of genes on behavior...
- The use of behavioral test batteries: effects of training historyK L McIlwain
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Physiol Behav 73:705-17. 2001..These two studies demonstrate that some behavioral tests appear to be sensitive to previous testing experience, while other tests are immune...
- Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strainsSheryl S Moy
North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Behav Brain Res 176:4-20. 2007..Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses...
- Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strainsRachel A Millstein
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane, Room 2N09, Rockville, MD 20852, USA
Neurosci Biobehav Rev 31:3-17. 2007..Data demonstrate that the MS procedure employed does not provide a robust model of early life stress effects on the anxiety- and depression-related behaviors in the mouse strains tested...
- Wild mouse open field behavior is embedded within the multidimensional data space spanned by laboratory inbred strainsE Fonio
Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
Genes Brain Behav 5:380-8. 2006..The implication could be that whereas natural selection favors moderate locomotor behavior in wild mice, the inbreeding process tends to generate in mice, in some of the features, extreme and more variable behavior...
- Gene differences influencing visual system function and behaviorJ P Hegmann
Behav Genet 4:165-70. 1974
- Advances in behavioral genetics modeling using Mplus: applications of factor mixture modeling to twin dataBengt Muthen
Graduate School of Education and Information Studies, University of California, Los Angeles, 90095, USA
Twin Res Hum Genet 9:313-24. 2006..The factor mixture approach appears to have great potential for the genetic analyses of heterogeneous populations. Generalizations for longitudinal data are also outlined...
- Is the genetic structure of human personality universal? A cross-cultural twin study from North America, Europe, and AsiaShinji Yamagata
Department of Cognitive and Behavioral Science, Graduate School of Arts and Sciences, University of Tokyo, Japan
J Pers Soc Psychol 90:987-98. 2006..These results suggest that the FFM has a solid biological basis and may represent a common heritage of the human species...
- Combined application of behavior genetics and microarray analysis to identify regional expression themes and gene-behavior associationsNoah E Letwin
Department of Functional Genomics, The Institute for Genomic Research, Rockville, Maryland 20850, USA
J Neurosci 26:5277-87. 2006..The approaches and data set described herein serve as a valuable resource to investigate the genetic underpinning of complex behaviors...
- Genetic fatalism and social policy: the implications of behavior genetics researchJ S Alper
Department of Chemistry, University of Massachusetts-Boston 02125, USA
Yale J Biol Med 66:511-24. 1993..between these concepts and the malleability of traits for both molecular and nonmolecular approaches to behavioral genetics. We argue that the malleability of traits is as much a social and political question as it is a biological ..
- Altered expression of Autism-associated genes in the brain of Fragile X mouse modelAiying Zhang
Department of Genetics, Peking University Health Science Center, Beijing 100083, China
Biochem Biophys Res Commun 379:920-3. 2009..J. Nadler, T.R. Magnuson, J.N. Crawley, Mouse models of autism spectrum disorders: the challenge for behavioral genetics, Am. J. Med. Genet. 142 (2006) 40-51]...
- Application of proteomics to ecology and population biologyT L Karr
Department of Biology and Biochemistry, University of Bath, Bath, UK
Heredity (Edinb) 100:200-6. 2008..There has been very little application of proteomics to the fields of behavioral genetics, evolution, ecology and population dynamics, and has only recently been effectively applied to the closely ..
- How neuroscience and behavioral genetics improve psychiatric assessment: report on a violent murder caseDavide Rigoni
Department of Developmental and Socialization Psychology, University of Padua Padua, Italy
Front Behav Neurosci 4:160. 2010..Here we report on a case in which cognitive neuroscience and behavioral genetics methods were applied to a psychiatric forensic evaluation conducted on a young woman, J.F...
- The evolution of the cognitive model of depression and its neurobiological correlatesAaron T Beck
Department of Psychiatry, University of Pennsylvania, 3535 Market St, Rm 2032, Philadelphia, PA 19104, USA
Am J Psychiatry 165:969-77. 2008..Combining findings from behavioral genetics and cognitive neuroscience with the accumulated research on the cognitive model opens new opportunities for ..
- Race and genetics: controversies in biomedical, behavioral, and forensic sciencesPilar Ossorio
Department of Medical History and Bioethics, University of Wisconsin Madison, Madison, WI 53706 1399, USA
Am Psychol 60:115-28. 2005..The article then discusses 1 context, criminology, in which the use of racial variables in behavioral genetics research could be particularly problematic...
- Short-term selection for the interaction between S-propranolol and ethanol in miceRichard A Deitrich
Department of Pharmacology, University of Colorado Health Science Center, Denver, Colorado 80262, USA
Alcohol Clin Exp Res 27:1236-40. 2003..Therefore, we carried out a short-term breeding project to determine whether the response could be selectively bred...
- Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decadesDouglas Wahlsten
Department of Psychology, University of Alberta, Edmonton, AB, Canada T6G 2E9
Proc Natl Acad Sci U S A 103:16364-9. 2006..classical study many years later, will we obtain the same results? Recent research with mice in neural and behavioral genetics yielded different results in different laboratories for certain phenotypes, and these findings suggested to ..
- PDK1 and HR46 gene homologs tie social behavior to ovary signalsYing Wang
School of Life Sciences, Arizona State University, Tempe, AZ, USA
PLoS ONE 4:e4899. 2009..The honey bee is a model for studying evolutionary behavioral genetics because of its well characterized age-correlated division of labor...
- Role of the family in the onset and outcome of childhood disorders: selected research findingsM Z Wamboldt
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Am Acad Child Adolesc Psychiatry 39:1212-9. 2000..family research were selected for review as being of special importance to the clinically oriented child and adolescent psychiatrist: behavioral genetics, expressed emotion, and the interaction of family dynamics and childhood illness.
- Drosophila genetics in the classroomW Sofer
Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08854 0759
Genetics 136:417-22. 1994..In recent years, the organism has also helped students understand biochemical and behavioral genetics. In this connection, this article describes the development of a set of integrated laboratory exercises and ..
- Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structureStephanie M Rollmann
Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
Genetics 179:1327-36. 2008..influences variation in brain structures and behavioral phenotypes represents a central challenge in behavioral genetics. In Drosophila melanogaster, the neuralized (neur) gene plays a key role in development of the nervous ..
- A logistic regression based extension of the TDT for continuous and categorical traitsI D Waldman
Department of Psychology, Emory University, Atlanta, GA 30322, USA
Ann Hum Genet 63:329-40. 1999..Given its features, we regard the logistic regression extension of the TDT as a flexible new data analytic method with extensive potential applications to problems in medical, psychiatric, and behavioral genetics.
- Development and modification of child food preferences and eating patterns: behavior genetics strategiesM S Faith
University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, PA 19104, USA
Int J Obes (Lond) 29:549-56. 2005b>Behavioral genetics (BG) designs can offer useful strategies for studying the development of child food preferences and eating patterns...
- Serotonin transporter promoter region (5-HTTLPR) polymorphism predicts resting respiratory sinus arrhythmiaAlissa J Ellis
Department of Psychology, The University of Texas at Austin, Austin, Texas 78712 0187, USA
Psychophysiology 48:923-6. 2011..Although behavioral genetics research indicates that RSA is partly heritable, relatively few molecular genetics studies have been ..
- Genetic analysis of sleepAmanda Crocker
Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genes Dev 24:1220-35. 2010..In the two decades since, there have been many advances in the field of behavioral genetics, but it is only in the past 10 years that the genetic analysis of sleep has emerged as an important ..
- Influences on child eating and weight development from a behavioral genetics perspectiveTanja V E Kral
University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Pediatr Psychol 34:596-605. 2009..The review concludes with an outlook on possibilities for future research efforts in the field...
- A gridded genomic library of the honeybee (Apis mellifera): a reference library system for basic and comparative genetic studies of a hymenopteran genomeM Beye
Institut für Okologie und Biologie, Technische Universitat Berlin, Germany
Genomics 49:317-20. 1998..the honeybee is becoming a model organism for genomic studies of naturally occurring traits and behavioral genetics. The library consists of about 110,000 clones spotted at high density onto four filter membranes, ..
- Review of twin and family studies on neuroanatomic phenotypes and typical neurodevelopmentJ Eric Schmitt
Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
Twin Res Hum Genet 10:683-94. 2007..At present, the majority of twin imaging studies are limited by sample sizes small by the standards of behavioral genetics; nevertheless the literature at present represents a pioneering effort in the pursuit of answers to many ..
- The role of genes and environment on trauma exposure and posttraumatic stress disorder symptoms: a review of twin studiesTracie O Afifi
Anxiety and Illness Behaviour Laboratory and Department of Psychology, University of Regina, 3737 Wascana Parkway, Regina, SK, Canada
Clin Psychol Rev 30:101-12. 2010....
- Behavioral genetics of thermosensation and hygrosensation in DrosophilaO Sayeed
Division of Biology, California Institute of Technology, Pasadena, 91125, USA
Proc Natl Acad Sci U S A 93:6079-84. 1996..Ablation experiments further separate these sensory systems by showing that thermoreceptors are housed in the third antennal segment, whereas hygroreceptors are located more distally in the antennal arista...
- Contributions and promise of human behavioral geneticsJ W Gilger
Department of Speech, Language, and Hearing, University of Kansas, Lawrence 66045, USA
Hum Biol 72:229-55. 2000Human behavioral genetics has contributed greatly to our understanding of human behavioral development...
- Behavioral Genetics of ImpulsivityLynn Fairbanks; Fiscal Year: 2005..b>Behavioral genetics studies have consistently demonstrated significant genetic contributions to individual differences in ..
- Force Plate Actometer for Measuring Behavior in RodentsCandice Kissinger; Fiscal Year: 2003..which can replace several different instruments, will find application in pharmacology, toxicology, behavioral genetics and behavioral neuroscience...
- The Psychobiology of Trauma and Resilience Across the LIfespanDean Kilpatrick; Fiscal Year: 2007..g., behavioral genetics, neuroscience, psychosocial, public health, biological, treatment outcome); 3) failure to consider the ..
- Internatl Conf.on the Future of Cognitive Aging ResearchDUANE ALWIN; Fiscal Year: 2005..experts on cognitive aging representing the fields of developmental psychology, psychiatry, neuroscience, behavioral genetics, demography, gerontology, sociology, economics, biostatistics, and epidemiology to gather for a two and one-..
- Temperament and Developmental PsychopathologyDavid Rettew; Fiscal Year: 2007..additional skills in three areas are identified as Traininq Goals: (1) Temperament assessment, (2) Behavioral genetics, (3) Relationship between temperamant and child psychopathology. Jim Hudziak, M.D. and Thomas Achenbach, Ph...
- Genetics of Fear and Anxiety DisordersJOHN HETTEMA; Fiscal Year: 2006..Hettema's primary sponsor. The training will take place at the Virginia Institute for Psychiatric and Behavioral Genetics of Virginia Commonwealth University, which provides a rich, stimulating environment for the conduct of ..
- NATURE & NURTURE IN SOCIAL DEMOGRAPHY: AN ADOPTION STUDYMichael Stallings; Fiscal Year: 2007..The proposed research is innovative, both in the field of behavioral genetics and the field of social demography, in that it brings behavioral genetic methods to bear on social ..
- NATURE & NURTURE IN SOCIAL DEMOGRAPHY: AN ADOPTION STUDYJohn DeFries; Fiscal Year: 2002..Significance: The proposed research is innovative, both in the fields of behavioral genetics and in social demography, in that it brings behavioral genetic methods to bear 1) on sociological and ..
- Molecular genetics of executive function in dyslexiaZoran Brkanac; Fiscal Year: 2007..grant is to help establish the candidate's independent research career in the field of psychiatric and behavioral genetics. The candidate has completed clinical training in psychiatry and child psychiatry, and has prior research ..
- BEHAVIORAL GENETICS--MODELS/MECHANISMS OF SCHIZOPHRENIAClinton Kilts; Fiscal Year: 2002..abstract_text> ..
- Predoctoral Training in Integrative NeuroscienceDavid Anderson; Fiscal Year: 2007..neurons); 3) behavior (simple and complex behaviors in vertebrates, arthropods, and nematodes, including behavioral genetics); 4) computational neuroscience (studies of single neurons, systems of neurons, and whole organisms)...