life style

Summary

Summary: Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed)

Top Publications

  1. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
  2. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
  3. pmc Which intervention characteristics are related to more exposure to internet-delivered healthy lifestyle promotion interventions? A systematic review
    Wendy Brouwer
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
    J Med Internet Res 13:e2. 2011
  4. ncbi Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease
    Marc T Hamilton
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Diabetes 56:2655-67. 2007
  5. pmc Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial
    Rena R Wing
    Department of Psychiatry, The Miriam Hospital Brown Medical School, Providence, RI 02860, USA
    Arch Intern Med 170:1566-75. 2010
  6. ncbi Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee
    Alice H Lichtenstein
    Circulation 114:82-96. 2006
  7. ncbi Diet, lifestyle, and the risk of type 2 diabetes mellitus in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 345:790-7. 2001
  8. ncbi Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 289:1785-91. 2003
  9. ncbi Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab)
    Genevieve N Healy
    School of Population Health, University of Queensland, Brisbane, Australia
    Diabetes Care 31:369-71. 2008
  10. ncbi The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study
    Guangwei Li
    Department of Endocrinology, China Japan Friendship Hospital, Beijing, China
    Lancet 371:1783-9. 2008

Detail Information

Publications353 found, 100 shown here

  1. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  2. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
    ..Whether type 2 diabetes can be prevented by interventions that affect the lifestyles of subjects at high risk for the disease is not known...
  3. pmc Which intervention characteristics are related to more exposure to internet-delivered healthy lifestyle promotion interventions? A systematic review
    Wendy Brouwer
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
    J Med Internet Res 13:e2. 2011
    ..However, there is no systematic overview of which characteristics of Internet-delivered interventions may be related to more exposure...
  4. ncbi Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease
    Marc T Hamilton
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Diabetes 56:2655-67. 2007
    ....
  5. pmc Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial
    Rena R Wing
    Department of Psychiatry, The Miriam Hospital Brown Medical School, Providence, RI 02860, USA
    Arch Intern Med 170:1566-75. 2010
    ..We examined the effects of lifestyle intervention on changes in weight, fitness, and CVD risk factors during a 4-year study...
  6. ncbi Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee
    Alice H Lichtenstein
    Circulation 114:82-96. 2006
    ..By adhering to these diet and lifestyle recommendations, Americans can substantially reduce their risk of developing cardiovascular disease, which remains the leading cause of morbidity and mortality in the United States...
  7. ncbi Diet, lifestyle, and the risk of type 2 diabetes mellitus in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 345:790-7. 2001
    ..Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown...
  8. ncbi Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 289:1785-91. 2003
    ..Current public health campaigns to reduce obesity and type 2 diabetes have largely focused on increasing exercise, but have paid little attention to the reduction of sedentary behaviors...
  9. ncbi Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab)
    Genevieve N Healy
    School of Population Health, University of Queensland, Brisbane, Australia
    Diabetes Care 31:369-71. 2008
    ..We examined the associations of objectively measured sedentary time and physical activity with continuous indexes of metabolic risk in Australian adults without known diabetes...
  10. ncbi The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study
    Guangwei Li
    Department of Endocrinology, China Japan Friendship Hospital, Beijing, China
    Lancet 371:1783-9. 2008
    ..We aimed to assess whether intensive lifestyle interventions have a long-term effect on the risk of diabetes, diabetes-related macrovascular and microvascular complications, and mortality...
  11. ncbi European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by r
    Ian Graham
    Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur Heart J 28:2375-414. 2007
  12. ncbi Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial
    R C Andrews
    School of Clinical Sciences, University of Bristol, Bristol, UK
    Lancet 378:129-39. 2011
    ..We investigated the effects of diet and physical activity on blood pressure and glucose concentrations...
  13. ncbi The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1)
    A Ramachandran
    Diabetes Research Centre, M V Hospital for Diabetes, WHO Collaborating Centre for Research, Education and Training in Diabetes, Royapuram, Chennai, India
    Diabetologia 49:289-97. 2006
    ..In a prospective community-based study, we tested whether the progression to diabetes could be influenced by interventions in native Asian Indians with IGT who were younger, leaner and more insulin resistant than the above populations...
  14. pmc Translating the Diabetes Prevention Program into the community. The DEPLOY Pilot Study
    Ronald T Ackermann
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Prev Med 35:357-63. 2008
    ..This study evaluated the delivery of a group-based DPP lifestyle intervention in partnership with the YMCA...
  15. ncbi Environmental contributions to the obesity epidemic
    J O Hill
    Colorado Clinical Nutrition Research Unit, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Science 280:1371-4. 1998
    ..Because obesity is difficult to treat, public health efforts need to be directed toward prevention...
  16. ncbi European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection
    E Riboli
    Unit of Nutrition and Cancer, International Agency for Research on Cancer IARC WHO, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Public Health Nutr 5:1113-24. 2002
    ..The present paper provides a description of the EPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort...
  17. ncbi Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial
    Lawrence J Appel
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Md 21205 2233, USA
    JAMA 289:2083-93. 2003
    ..The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP. To date, no trial has evaluated the effects of simultaneously implementing these lifestyle recommendations...
  18. ncbi Self-management education for adults with type 2 diabetes: a meta-analysis of the effect on glycemic control
    Susan L Norris
    Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 25:1159-71. 2002
    ..To evaluate the efficacy of self-management education on GHb in adults with type 2 diabetes...
  19. pmc Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population study
    Kay Tee Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    PLoS Med 5:e12. 2008
    ..We aimed to quantify the potential combined impact of four health behaviours on mortality in men and women living in the general community...
  20. pmc Effect of weight loss with lifestyle intervention on risk of diabetes
    Richard F Hamman
    Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    Diabetes Care 29:2102-7. 2006
    ..We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS participants...
  21. ncbi Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men
    F B Hu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 161:1542-8. 2001
    ..Television (TV) watching, a major sedentary behavior in the United States, has been associated with obesity. We hypothesized that prolonged TV watching may increase risk for type 2 diabetes...
  22. pmc Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis
    Clare L Gillies
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester LE1 7RH
    BMJ 334:299. 2007
    ..To quantify the effectiveness of pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance...
  23. ncbi Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study
    Mark A Pereira
    Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 287:2081-9. 2002
    ..Although diet has been postulated to influence IRS, the independent effects of dairy consumption on development of this syndrome have not been investigated...
  24. ncbi Objectively measured light-intensity physical activity is independently associated with 2-h plasma glucose
    Genevieve N Healy
    Cancer Prevention Research Centre, School of Population Health, The University of Queensland, Brisbane, Australia
    Diabetes Care 30:1384-9. 2007
    ..We examined the associations of objectively measured sedentary time, light-intensity physical activity, and moderate- to vigorous-intensity activity with fasting and 2-h postchallenge plasma glucose in Australian adults...
  25. pmc Lifestyle intervention for prevention of type 2 diabetes in primary health care: one-year follow-up of the Finnish National Diabetes Prevention Program (FIN-D2D)
    Timo Saaristo
    Pirkanmaa Hospital District, Tampere, Finland
    Diabetes Care 33:2146-51. 2010
    ..To investigate 1-year outcomes of a national diabetes prevention program in Finland...
  26. ncbi A European evidence-based guideline for the prevention of type 2 diabetes
    B Paulweber
    Paracelsus Medical University, Salzburg, Austria
    Horm Metab Res 42:S3-36. 2010
    ..The prevalence and socioeconomic burden of type 2 diabetes (T2DM) and associated co-morbidities are rising worldwide...
  27. pmc Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Pittsburgh, MUH N810, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    JAMA 304:1795-802. 2010
    ....
  28. pmc A two-year randomized trial of obesity treatment in primary care practice
    Thomas A Wadden
    Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    N Engl J Med 365:1969-79. 2011
    ..This randomized trial compared weight loss during a 2-year period in response to three lifestyle interventions, all delivered by PCPs in collaboration with auxiliary health professionals (lifestyle coaches) in their practices...
  29. ncbi Maternal obesity: pregnancy complications, gestational weight gain and nutrition
    I Guelinckx
    Department of Nutrition and Health Preventive Medicine, Catholic University Leuven, University Hospital Gasthuisberg, Leuven, Belgium
    Obes Rev 9:140-50. 2008
    ..This review aims to summarize the complications associated with maternal prepregnancy overweight and obesity and to discuss possible strategies to improve the lifestyle habits of pregnant women...
  30. ncbi Plasma adiponectin levels and risk of myocardial infarction in men
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Channing Laboratory, Boston, Mass 02115, USA
    JAMA 291:1730-7. 2004
    ..Adiponectin, a recently discovered adipocyte-derived peptide, is involved in the regulation of insulin sensitivity and lipid oxidation and, purportedly, in the development of atherosclerosis and coronary heart disease in humans...
  31. pmc Effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: cluster randomised controlled trial
    M J Davies
    Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW
    BMJ 336:491-5. 2008
    ..To evaluate the effectiveness of a structured group education programme on biomedical, psychosocial, and lifestyle measures in people with newly diagnosed type 2 diabetes...
  32. ncbi The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidence
    Rachel R Huxley
    The George Institute for International Health, University of Sydney, Sydney, Australia
    Int J Cancer 125:171-80. 2009
    ....
  33. pmc Non-communicable diseases in low- and middle-income countries: context, determinants and health policy
    J J Miranda
    Non communicable Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 13:1225-34. 2008
    ..Finally, the need for health system reform to strengthen primary care is highlighted as a major policy to reduce the toll of this rising epidemic...
  34. ncbi Characteristics of visitors and revisitors to an Internet-delivered computer-tailored lifestyle intervention implemented for use by the general public
    Wendy Brouwer
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Health Educ Res 25:585-95. 2010
    ..e. men, older and lower educated persons...
  35. pmc Primary prevention of gestational diabetes mellitus and large-for-gestational-age newborns by lifestyle counseling: a cluster-randomized controlled trial
    Riitta Luoto
    UKK Institute for Health Promotion Research, Tampere, Finland
    PLoS Med 8:e1001036. 2011
    ..Our objective was to examine whether gestational diabetes mellitus (GDM) or newborns' high birthweight can be prevented by lifestyle counseling in pregnant women at high risk of GDM...
  36. ncbi Type 2 diabetes prevention in the "real world": one-year results of the GOAL Implementation Trial
    Pilvikki Absetz
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    Diabetes Care 30:2465-70. 2007
    ..We report on the program's effectiveness as well as findings related to the program's reach, adoption, and implementation...
  37. ncbi Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance: the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)
    Elizabeth L M Barr
    International Diabetes Institute, 250 Kooyong Rd, Caulfield, Victoria, 3162, Australia
    Circulation 116:151-7. 2007
    ..This study investigated whether impaired fasting glucose and impaired glucose tolerance, as well as diabetes mellitus, increase the risk of all-cause and CVD mortality...
  38. ncbi Sedentary behaviour and obesity development in children and adolescents
    Juan Pablo Rey-López
    HELENA Study Group, School of Health Sciences, University of Zaragoza, Edificio Cervantes, 2nd Floor, C Corona de Aragón 42, 50009 Zaragoza, Spain
    Nutr Metab Cardiovasc Dis 18:242-51. 2008
    ..Mechanisms that explain the link between sedentariness and obesity are also discussed. Finally, future studies should take into account important mediators such as socioeconomic status and family structure...
  39. ncbi Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education Program
    Paul K Whelton
    Department of Epidemiology and Medicine, Tulane University Health Sciences Center, Tulane University, New Orleans, LA, USA
    JAMA 288:1882-8. 2002
    ....
  40. ncbi Recommended community strategies and measurements to prevent obesity in the United States
    Laura Kettel Khan
    Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, CDC, USA
    MMWR Recomm Rep 58:1-26. 2009
    ....
  41. ncbi Tackling of unhealthy diets, physical inactivity, and obesity: health effects and cost-effectiveness
    Michele Cecchini
    Health Division, Organisation for Economic Co operation and Development OECD, Paris, France
    Lancet 376:1775-84. 2010
    ..A package of measures for the prevention of chronic diseases would deliver substantial health gains, with a very favourable cost-effectiveness profile...
  42. pmc Rates and determinants of repeated participation in a web-based behavior change program for healthy body weight and healthy lifestyle
    Marieke W Verheijden
    TNO Quality of Life, CE Leiden, The Netherlands
    J Med Internet Res 9:e1. 2007
    ..However, because of the known dose-response relationship between the intensity and frequency of counseling and the behavior change outcomes, selective retention may also be a concern...
  43. ncbi Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999-2000
    Kathy Radimer
    Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    Am J Epidemiol 160:339-49. 2004
    ....
  44. ncbi Sexual behaviour in Britain: partnerships, practices, and HIV risk behaviours
    A M Johnson
    Centre for Infectious Disease Epidemiology, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Mortimer Market Centre, WC1E 6AU, London, UK
    Lancet 358:1835-42. 2001
    ....
  45. pmc Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions
    Robert E Ratner
    MedStar Research Institute, Hyattsville, Maryland 20783, USA
    J Clin Endocrinol Metab 93:4774-9. 2008
    ..A past history of gestational diabetes mellitus (GDM) confers a very high risk of postpartum development of diabetes, particularly type 2 diabetes...
  46. ncbi Sedentary behavior, physical activity, and the metabolic syndrome among U.S. adults
    Earl S Ford
    Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Obes Res 13:608-14. 2005
    ..We examined the associations among physical activity, sedentary behavior, and metabolic syndrome in a representative sample of U.S. adults...
  47. ncbi Parents as agents of change in childhood obesity--from research to practice
    Moria Golan
    School of Nutritional Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
    Int J Pediatr Obes 1:66-76. 2006
    ..01) and with less weight loss (p < 0.05). Omitting the obese child from direct intervention and targeting parents only is a cost-effective approach with integrated messages for the management of weight-related problems...
  48. ncbi An active and socially integrated lifestyle in late life might protect against dementia
    Laura Fratiglioni
    Aging Research Center, Division of Geriatric Epidemiology and Medicine, Neurotec Department, Karolinska Institute and Stockholm Gerontology Research Center, Stockholm, Sweden
    Lancet Neurol 3:343-53. 2004
    ..Further research is necessary to better define the mechanisms of these associations and better delineate preventive and therapeutic strategies...
  49. pmc Motives for (not) participating in a lifestyle intervention trial
    Jeroen Lakerveld
    Department of General Practice, EMGO Institute, VU University Medical Center, V, d, Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    BMC Med Res Methodol 8:17. 2008
    ....
  50. ncbi Study design, exposure variables, and socioeconomic determinants of participation in Diet, Cancer and Health: a population-based prospective cohort study of 57,053 men and women in Denmark
    Anne Tjønneland
    Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
    Scand J Public Health 35:432-41. 2007
    ..The aims of this paper are to give a description of the study design, measurement procedures, and differences between participants and non-participants with special reference to socioeconomic characteristics...
  51. ncbi Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004-BHS IV
    B Williams
    Department of Cardiovascular Sciences, Clinical Sciences Building, Leicester Royal Infirmary, University of Leicester, UK
    J Hum Hypertens 18:139-85. 2004
  52. ncbi A brief review on correlates of physical activity and sedentariness in youth
    Klazine van der Horst
    EMGO Institute, Department of Public and Occupational Health, VU University Medical Center, Amsterdam, The Netherlands
    Med Sci Sports Exerc 39:1241-50. 2007
    ..The main goal of this systematic review is to summarize and update the existing literature on correlates of young people's physical activity, insufficient physical activity, and sedentary behavior...
  53. ncbi Sexual behavior in the United States: results from a national probability sample of men and women ages 14-94
    Debby Herbenick
    Center for Sexual Health Promotion, Indiana University, Bloomington, IN, USA
    J Sex Med 7:255-65. 2010
    ..Despite a demonstrated relationship between sexual behaviors and health, including clinical risks, little is known about contemporary sexual behavior...
  54. pmc The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it
    Thomas A Wadden
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA corrected
    Obesity (Silver Spring) 14:737-52. 2006
    ..After Year 4, participants are offered monthly individual visits. The intervention is delivered by a multidisciplinary team that includes medical staff who monitor participants at risk of hypoglycemic episodes...
  55. ncbi Clustering of lifestyle risk factors in a general adult population
    A Jantine Schuit
    Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, P O Box 1, 3720 BA Bilthoven, The Netherlands
    Prev Med 35:219-24. 2002
    ..The objective of the study was to evaluate the degree of clustering of common lifestyle risk factors in a general adult population and to define subgroups with elevated clustering...
  56. doi Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association
    John P Bantle
    Diabetes Care 31:S61-78. 2008
  57. ncbi Reliability and validity of self-reported physical activity in the Nord-Trøndelag Health Study: HUNT 1
    Nanna Kurtze
    HUNT Research Centre, Faculty of Medicine, Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
    Scand J Public Health 36:52-61. 2008
    ..A third, HUNT 3, started in 2006. However, the physical activity (PA) questionnaires have not yet been validated...
  58. ncbi American College of Sports Medicine Position Stand: physical activity and bone health
    Wendy M Kohrt
    Med Sci Sports Exerc 36:1985-96. 2004
  59. ncbi Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
    Lars Sjöström
    Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    N Engl J Med 351:2683-93. 2004
    ..Weight loss is associated with short-term amelioration and prevention of metabolic and cardiovascular risk, but whether these benefits persist over time is unknown...
  60. ncbi Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study
    Jaana Lindström
    Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Lancet 368:1673-9. 2006
    ..In the extended follow-up of the Finnish Diabetes Prevention Study, we assessed the extent to which the originally-achieved lifestyle changes and risk reduction remain after discontinuation of active counselling...
  61. ncbi Parents are key players in the prevention and treatment of weight-related problems
    Moria Golan
    School of Nutritional Sciences, Faculty of Agriculture, Food and Environmental Quality Sciences, Rehovot, 76100, Israel
    Nutr Rev 62:39-50. 2004
    ..This paper reviews the environmental risk factors and parents' role in the prevention and treatment of children's weight-related problems...
  62. ncbi Problems in identifying predictors and correlates of weight loss and maintenance: implications for weight control therapies based on behaviour change
    J Stubbs
    Slimming World, Alfreton, UK
    Obes Rev 12:688-708. 2011
    ..This information will help people shape behaviour change solutions to their own lifestyle needs...
  63. pmc Tailored print communication and telephone motivational interviewing are equally successful in improving multiple lifestyle behaviors in a randomized controlled trial
    Hilde M van Keulen
    Department of Health Promotion, Maastricht University, The Netherlands
    Ann Behav Med 41:104-18. 2011
    ..Computer tailoring and motivational interviewing show promise in promoting lifestyle change, despite few head-to-head comparative studies...
  64. pmc Effect of multidimensional lifestyle intervention on fitness and adiposity in predominantly migrant preschool children (Ballabeina): cluster randomised controlled trial
    J J Puder
    Service of Endocrinology, Diabetes and Metabolism, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    BMJ 343:d6195. 2011
    ..To test the effect of a multidimensional lifestyle intervention on aerobic fitness and adiposity in predominantly migrant preschool children...
  65. pmc Achieving weight and activity goals among diabetes prevention program lifestyle participants
    Rena R Wing
    Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
    Obes Res 12:1426-34. 2004
    ..This paper examines demographic, psychosocial, and behavioral factors related to achieving weight loss and physical activity goals in the DPP lifestyle participants...
  66. ncbi Obesity and the environment: where do we go from here?
    James O Hill
    Center for Human Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Science 299:853-5. 2003
    ..Having a specific behavioral target for the prevention of weight gain may be key to arresting the obesity epidemic...
  67. pmc Four-year weight losses in the Look AHEAD study: factors associated with long-term success
    Thomas A Wadden
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:1987-98. 2011
    ..e., ≥ 5%) in overweight/obese participants with type 2 diabetes and maintain this loss in more than 45% of patients at 4 years...
  68. pmc Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    Kittichai Promrat
    Division of Gastroenterology and Hepatology, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Hepatology 51:121-9. 2010
    ..36 versus -0.41, P < 0.001), lobular inflammation (-0.82 versus -0.24, P = 0.03), ballooning injury (-1.27 versus -0.53, P = 0.03) and NAS (-3.45 versus -1.18, P < 0.001)...
  69. ncbi Associations of TV viewing and physical activity with the metabolic syndrome in Australian adults
    D W Dunstan
    International Diabetes Institute, Melbourne, Victoria, Australia
    Diabetologia 48:2254-61. 2005
    ..We analysed a sample of Australian adults to determine the strength of associations of TV viewing and participation in physical activity with the metabolic syndrome...
  70. pmc EPODE approach for childhood obesity prevention: methods, progress and international development
    J M Borys
    EPODE European Network Coordinating Team, Protéines, Paris, France
    Obes Rev 13:299-315. 2012
    ..Since 2004, EPODE methodology has been implemented in more than 500 communities in six countries. Community-based interventions are integral to childhood obesity prevention. EPODE provides a valuable model to address this challenge...
  71. ncbi Sources of variance in daily physical activity levels as measured by an accelerometer
    Charles E Matthews
    Department of Epidemiology and Biostatistics, Norman J Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    Med Sci Sports Exerc 34:1376-81. 2002
    ..To examine sources of variance in objective measures of physical activity in a group of healthy adults (N = 92) participating in a physical activity measurement study...
  72. ncbi Associated risk of XRCC1 and XPD cross talk and life style factors in progression of head and neck cancer in north Indian population
    Anil Kumar
    CSIR Indian Institute of Toxicology Research CSIR IITR, Lucknow, India
    Mutat Res 729:24-34. 2012
    ..Further, XRCC1 Arg280His variant though dormant individually, may also contribute to the development of cancer in combination with XPD Arg751Gln...
  73. ncbi Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study
    Nicola M McKeown
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:390-8. 2002
    ..The influence of whole grains on cardiovascular disease risk may be mediated through multiple pathways, eg, a reduction in blood lipids and blood pressure, an enhancement of insulin sensitivity, and an improvement in blood glucose control...
  74. ncbi EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries
    Kornelia Kotseva
    Department of Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Eur J Cardiovasc Prev Rehabil 16:121-37. 2009
    ....
  75. ncbi Interventions for the prevention of overweight and obesity in preschool children: a systematic review of randomized controlled trials
    L Monasta
    Epidemiology and Biostatistics Unit, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Italy
    Obes Rev 12:e107-18. 2011
    ..More rigorous research is needed on interventions and on social and environmental factors that could impact on lifestyle...
  76. ncbi The impact of a Mediterranean diet and healthy lifestyle on premature mortality in men and women
    Piet A van den Brandt
    Department of Epidemiology, Schools for Oncology and Developmental Biology and Public Health and Primary Care, Maastricht University Medical Centre, Netherlands
    Am J Clin Nutr 94:913-20. 2011
    ..The Mediterranean diet has been associated with reduced mortality; few studies have investigated the combined impact of the Mediterranean diet with other modifiable lifestyle factors...
  77. ncbi Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study
    Sheila A Bingham
    MRC Dunn Human Nutrition Unit, Cambridge, UK
    Lancet 361:1496-501. 2003
    ..Dietary fibre is thought to protect against colorectal cancer but this view has been challenged by recent prospective and intervention studies that showed no protective effect...
  78. pmc Lifestyle counseling for type 2 diabetes risk reduction in Dutch primary care: results of the APHRODITE study after 0.5 and 1.5 years
    Paulina W A Vermunt
    University of Tilburg, Tilburg, The Netherlands
    Diabetes Care 34:1919-25. 2011
    ..In particular, the level of experience of the nurse practitioner and the availability of partner support seem to facilitate intervention success...
  79. ncbi Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion
    Gilbert P August
    George Washington University School of Medicine, Washington, D C 20037, USA
    J Clin Endocrinol Metab 93:4576-99. 2008
    ..Our objective was to formulate practice guidelines for the treatment and prevention of pediatric obesity...
  80. ncbi Motivational interviewing in health settings: a review
    Eileen Britt
    Department of Psychology, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Patient Educ Couns 53:147-55. 2004
    ..The current paper provides an overview of MI, with particular reference to its application to health problems...
  81. pmc 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]
    David C W Lau
    Department of Medicine, Julia McFarlane Diabetes Research Centre, Diabetes and Endocrine Research Group, University of Calgary, Calgary, Alta
    CMAJ 176:S1-13. 2007
  82. ncbi Optimal diets for prevention of coronary heart disease
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    JAMA 288:2569-78. 2002
    ..Thus, identification of the dietary changes that most effectively prevent CHD is critical...
  83. ncbi Measuring adaptations of motivational interviewing: the development and validation of the behavior change counseling index (BECCI)
    Claire Lane
    Communication Skills Unit, Department of General Practice, University of Wales College of Medicine, Llanedeyrn Health Center, Cardiff CF23 9PN, UK
    Patient Educ Couns 56:166-73. 2005
    ..BECCI will also provide valuable information about the standard of BCC that practitioners were trained to deliver in studies of BCC as an intervention...
  84. pmc Prevention of type 2 diabetes by lifestyle intervention in an Australian primary health care setting: Greater Green Triangle (GGT) Diabetes Prevention Project
    Tiina Laatikainen
    Greater Green Triangle University Department of Rural Health, Flinders and Deakin Universities, PO Box 423, Warrnambool, Victoria, 3280, Australia
    BMC Public Health 7:249. 2007
    ..Randomised controlled trials demonstrate a 60% reduction in type 2 diabetes incidence through lifestyle modification programmes. The aim of this study is to determine whether such programmes are feasible in primary health care...
  85. ncbi The Australian Diabetes, Obesity and Lifestyle Study (AusDiab)--methods and response rates
    David W Dunstan
    The International Diabetes Institute, 250 Kooyong Road, Caulfield, VIC 3162, Australia
    Diabetes Res Clin Pract 57:119-29. 2002
    ..Furthermore, it generates the baseline data for a prospective 5-year cohort study. The data will be important for national and regional public health and lifestyle education and health promotion programs...
  86. ncbi Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome
    David E Laaksonen
    Department of Physiology, University of Kuopio, Kuopio, Finland Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Diabetes Care 25:1612-8. 2002
    ..We studied the associations of LTPA and cardiorespiratory fitness with development of the metabolic syndrome (World Health Organization [WHO] and the National Cholesterol Education Program [NCEP] definitions)...
  87. ncbi Effect of lifestyle intervention on dietary habits, physical activity, and gestational weight gain in obese pregnant women: a randomized controlled trial
    Isabelle Guelinckx
    Department of Nutrition Public Health Medicine, LFoRCe, Catholic University Leuven, Leuven, Belgium
    Am J Clin Nutr 91:373-80. 2010
    ..Maternal obesity and excessive gestational weight gain (GWG) are major short- and long-term risk factors for maternal and fetal complications...
  88. ncbi Lifestyle modification and prevention of type 2 diabetes in overweight Japanese with impaired fasting glucose levels: a randomized controlled trial
    Toshikazu Saito
    Department of Internal Medicine, Social Insurance Chuo General Hospital, Tokyo, Japan
    Arch Intern Med 171:1352-60. 2011
    ..We investigated the efficacy of lifestyle modification on type 2 diabetes incidence among those with impaired fasting glucose levels...
  89. ncbi The prevalence and clustering of four major lifestyle risk factors in an English adult population
    Wouter Poortinga
    Cardiff University, UK
    Prev Med 44:124-8. 2007
    ....
  90. ncbi Physical activity and survival after colorectal cancer diagnosis
    Jeffrey A Meyerhardt
    Division of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 24:3527-34. 2006
    ..Physically active individuals have a lower risk of developing colorectal cancer but the influence of exercise on cancer survival is unknown...
  91. pmc The influence of user characteristics and a periodic email prompt on exposure to an internet-delivered computer-tailored lifestyle program
    Francine Schneider
    Caphri, Department of Health Promotion, Maastricht University, Maastricht, Netherlands
    J Med Internet Res 14:e40. 2012
    ..Actual exposure to CT interventions is not living up to its high expectations, as only a (limited) proportion of the target group is actually using these programs...
  92. ncbi Meeting recommendations for multiple healthy lifestyle factors. Prevalence, clustering, and predictors among adolescent, adult, and senior health plan members
    Nicolaas P Pronk
    Center for Health Promotion, HealthPartners Research Foundation, HealthPartners, Minneapolis, Minnesota, USA
    Am J Prev Med 27:25-33. 2004
    ..Such data may guide both clinical and health policy decision making and person-centered approaches to population health improvement...
  93. ncbi Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial
    Patricia J Elmer
    Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    Ann Intern Med 144:485-95. 2006
    ..The main 6-month results from the PREMIER trial showed that comprehensive behavioral intervention programs improve lifestyle behaviors and lower blood pressure...
  94. ncbi A community-based diabetes prevention and management education program in a rural village in India
    Padmini Balagopal
    Gandhigram Rural Institute, Tamilnadu, India
    Diabetes Care 31:1097-104. 2008
    ..In this study we evaluated a 7-month community-based nonpharmacological lifestyle intervention to prevent/reduce the risk of developing diabetes and its complications in a resource-poor village in Tamilnadu, India...
  95. ncbi Survey non-response in the Netherlands: effects on prevalence estimates and associations
    A Jeanne M van Loon
    National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Ann Epidemiol 13:105-10. 2003
    ..Both forms of non-response bias are investigated in a study on psychosocial factors and cancer risk, which is a sub-study of a large-scale monitoring survey in the Netherlands...
  96. pmc Primary care nurses struggle with lifestyle counseling in diabetes care: a qualitative analysis
    Renate Jansink
    Scientific Institute for Quality of Healthcare, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    BMC Fam Pract 11:41. 2010
    ..Based on this information we will develop an implementation strategy to improve lifestyle behavior change in general practice...
  97. ncbi Serious mental illness and physical health problems: a discussion paper
    Debbie Robson
    Health Services Research Department, King s College London, Section of Psychiatric Nursing, Institute of Psychiatry, De Crespigny Park, London, UK
    Int J Nurs Stud 44:457-66. 2007
    ..There are opportunities for mental health nurses to play a significant role in improving both the physical and mental health of people with serious mental illness...
  98. ncbi Association of body fat distribution with proinflammatory gene expression in peripheral blood mononuclear cells from young adult subjects
    Helen Hermana Miranda Hermsdorff
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    OMICS 14:297-307. 2010
    ....
  99. ncbi Comparison of lifestyle and structured interventions to increase physical activity and cardiorespiratory fitness: a randomized trial
    A L Dunn
    The Cooper Institute for Aerobics Research, Dallas, TX 75230, USA
    JAMA 281:327-34. 1999
    ..Traditional methods of prescribing exercise have not proven effective for increasing and maintaining a program of regular physical activity...
  100. pmc Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial
    Xavier Pi-Sunyer
    St Luke s Roosevelt Hospital Center, USA
    Diabetes Care 30:1374-83. 2007
    ..This report describes 1-year changes in CVD risk factors in a trial designed to examine the long-term effects of an intensive lifestyle intervention on the incidence of major CVD events...
  101. ncbi Increased television viewing is associated with elevated body fatness but not with lower total energy expenditure in children
    Diane M Jackson
    Division of Obesity and Metabolic Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen, Scotland, UK
    Am J Clin Nutr 89:1031-6. 2009
    ..Television (TV) viewing in children is associated with a higher body mass index, but it is unknown whether this reflects body fatness, and, if it does, why...

Research Grants77

  1. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..In yet another study, results suggest that maternal occupational exposure to agricultural chemicals may increase the risk of giving birth to a child with limb defects. ..
  2. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..In yet another study, results suggest that maternal occupational exposure to agricultural chemicals may increase the risk of giving birth to a child with limb defects. ..
  3. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..The overall objective is to understand the effects of obesity, physical activity and allergic sensitization in relation to symptoms of breathlessness and airway obstruction. ..
  4. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    ....
  5. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..We seek support for additional blood markers to PROMIS by assaying plasma biomarkers potentially relevant to atherogenesis, plaque rupture and/or thrombosis. ..
  6. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..The results of this research may provide a better understanding of ways to prevent and/or treat diabetes and its cardiovascular complications for millions of Americans. ..
  7. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    ..The PLCO participants are comparable to the general United States population. Life style, dietary and risk factor information was collected from participants...
  8. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    ..The PLCO participants are comparable to the general United States population. Life style, dietary and risk factor information was collected from participants...
  9. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..Before we can properly design prevention trials with the right intervention, the right target population and the right endpoints, we need preliminary studies for guidance, such as we have proposed. ..
  10. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..The findings of the proposed study will have great impact on reducing incidence and mortality of lung and liver cancers in humans. ..
  11. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..The existing resources for this secondary data analysis provide an unprecedented cost- efficient opportunity to build on established work and expand knowledge in this important area of public health. ..
  12. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..Shorter telomeres have been linked to cancer risk. The project includes 438 postmenopausal, overweight/obese, sedentary women who have already completed the trial from which blood samples will be used. ..
  13. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..Finally, it is expected that these studies will reveal additional potential benefits of n-3 PUFA consumption on silica-induced lung disease and fibrosis, another understudied area. ..
  14. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..The greatest potential for arresting this epidemic is likely to come through a clearer understanding of its molecular pathogenesis to develop rational and mechanism based therapy. ..
  15. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ....
  16. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    ..The SHIP study will provide insight into the pathophysiology of glucose intolerance, and the findings will have implications not only for diabetes prevention but also for other diseases that focus on sex hormones as mediators. ..
  17. The Somatotropic Axis and Health Aging: A Search for Mechanisms
    Andrzej Bartke; Fiscal Year: 2013
    ..5. To prepare annual progress reports and coordinate preparation of a competing renewal application. ..
  18. Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia after SCI
    Kenneth J Gustafson; Fiscal Year: 2012
    ..This approach is less invasive than existing devices and is expected to expand the population of individuals able to benefit from neural stimulation systems to restore bladder function. ..
  19. A Culturally Tailored LIfestyle Intervention to Prevent Diabetes in South Asians:
    KABAYAM M VENKAT NARAYAN; Fiscal Year: 2010
    ..The outcomes of this project could be used to plan larger interventions to prevent diabetes in South Asians, a rapidly growing segment of the US population. ..
  20. Arsenic Exposure, Genetic Determinants and Diabetes Risk in a Family Study
    Ana Navas-Acien; Fiscal Year: 2013
    ....
  21. PRE- AND POSTGRADUATE TRAINING IN MOLECULAR HEMATOLOGY
    J Evan Sadler; Fiscal Year: 2013
    ..Completion of this program will prepare talented trainees for careers in basic and translational hematology research, to make discoveries that will transform the diagnosis and treatment of hematologic diseases. ..
  22. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2010
    ..This animal model will provide academic and industrial research communities with an opportunity to better understand cardiovascular disease and its pathogenesis, and to develop and test new therapeutics and preventative strategies. ..
  23. CT Evaluation of the Myocardial Effects of Risk Factors
    Lilach O Lerman; Fiscal Year: 2013
    ..The proposed studies could contribute towards our understanding of the cardiovascular effects of the metabolic syndrome, and towards development of imaging strategies for assessment of its evolution and mechanisms. ..
  24. Mechanisms of Obesity in Mice with Neuron-Specific Lipoprotein Lipase Deficiency
    Robert H Eckel; Fiscal Year: 2013
    ....
  25. K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresis
    ROBERT FRANKLIN REILLY; Fiscal Year: 2010
    ....
  26. Oxidative Stress in Chronic Kidney Disease
    Talat Alp Ikizler; Fiscal Year: 2012
    ..We further hypothesize that implementation of caloric restriction and aerobic exercise is feasible and can improve the metabolic milieu. ..
  27. Sex-Hormones and the TMPRSS2: ERG Fusion in Prostate Cancer Progression
    Lorelei Mucci; Fiscal Year: 2013
    ....
  28. Diet Quality and CVD Risk Factors in a Family Based Weight Management Study
    Alice H Lichtenstein; Fiscal Year: 2013
    ..S., a public health problem that threatens to overwhelm our healthcare system. (End of Abstract) ..
  29. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2012
    ..Thus, this work will accelerate the discovery of novel therapies for this costly and deadly disease. ..
  30. Growth hormone and adult physiology
    Rhonda D Kineman; Fiscal Year: 2013
    ..Information gained can be used in future experiments to determine if GH acts directly or indirectly on specific tissues/cells to mediate these effects. ..
  31. The Role of Circadian Periodicity in Human Cardiovascular Disease and Diabetes
    John P Forman; Fiscal Year: 2013
    ..Our project may help provide a framework for innovative approaches in cardiovascular disease and diabetes treatment and prevention. ..
  32. Novel PPAR-Independent Peroxisome Proliferators for Type 2 Diabetes
    LIDIA NIEROBISZ; Fiscal Year: 2011
    ..We propose to develop novel PPAR-Independent Peroxisome Proliferators for Type 2 Diabetes to address this market need. ..
  33. Imaging of Aortic Atherosclerosis and Inflammation in the Metabolic Syndrome
    Warren J Manning; Fiscal Year: 2012
    ....
  34. Genetics of Angiotensinogen-Mediated Hypertension: Stage, Background & Gender
    Donald E Kohan; Fiscal Year: 2010
    ..Our goal is to advance the specificity of clinical management and treatment of EH. ..
  35. Remodeling of Lipid Metabolism by Dietary Methionine Restriction
    ERIC PAUL PLAISANCE; Fiscal Year: 2012
    ....
  36. Familial and Birth Cohort Effects on the Aging Senses
    Karen J Cruickshanks; Fiscal Year: 2013
    ..Understanding factors associated with the development of these conditions could lead to new treatments targeted at improving health for tomorrow's elders. ..
  37. Multiplexed DNA Origami-Based Biomarker Detection Assay for Early Dx of Arthritis
    John E Mueller; Fiscal Year: 2013
    ..g. weight loss) to increase their quality of life. Lastly, if the feasibility of the method is demonstrated, the method could be applied to other candidate biomarkers in AR. ..
  38. Reducing Preterm Births in Underserved Pregnant Women
    JAMES G CHRISTIAN; Fiscal Year: 2011
    ..If the proposed system proves to be effective in reducing preterm births it can improve maternal and child quality of life as well as reduce the economic burden of preterm births in the U.S. ..
  39. Muscle Wasting in Uremia
    Ralph Rabkin; Fiscal Year: 2012
    ....
  40. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ....
  41. Carbohydrate Regulation of Hepatic Gene Expression
    Kosaku Uyeda; Fiscal Year: 2010
    ..This knowledge will provide information that may be useful in developing strategies for the prevention and treatment of obesity. ..
  42. The Greatest Generation: The NAS-NRC WWII Twin Registry as a Scientific Resource
    Margaret Gatz; Fiscal Year: 2012
    ....
  43. Regulation of Metabolism by Dietary Sterols
    SHAILENDRA BHANUBHAI PATEL; Fiscal Year: 2013
    ..Some data from animal studies indicate improvement in atherosclerosis, but aggravation of stroke. These studies are important because they may help guide nutritional advice for a very large proportion of the patient population. ..
  44. Developmental Origins of Phenotypic Characteristics that Predict Longevity
    Andrzej Bartke; Fiscal Year: 2012
    ....
  45. NEWBORN IRON DEFICIENCY
    Michael K Georgieff; Fiscal Year: 2013
    ....
  46. NAFLD in T2DM: Prevalence in Hispanics and Role of Treatment
    Kenneth Cusi; Fiscal Year: 2013
    ....
  47. Lifestyle and Molecular Factors of Bone Health in Breast Cancer Survivors
    Song Yao; Fiscal Year: 2013
    ..In the Pathways Study, we now have an exceptional opportunity to address an important gap in breast cancer survivorship research, and to reduce the burden of AI-induced osteoporotic fractures in a real-world clinical setting. ..
  48. Epigenomic Regulation of Gene Expression in Diet Induced Obesity
    Donald K Scott; Fiscal Year: 2012
    ..This project has the potential to provide groundbreaking information concerning the epigenetics of obesity. ..
  49. CYCLE REGULATION IN THE SYMBIONT SINORHIZOBIUM MELILOTI
    KATHERINE ELISABETH GIBSON; Fiscal Year: 2011
    ....
  50. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    Richard S Legro; Fiscal Year: 2012
    ..Our goal is to develop safe and effective treatments to improve the treatment of infertility in women with PCOS, but the findings can be generalized to all women with PCOS. ..
  51. Delayed pubertal development on the mechanism of bone loss at maturity
    Vanessa R Yingling; Fiscal Year: 2011
    ..Therefore, the failure to accrue peak bone mass during the adolescent years represents a missed opportunity to optimize bone mass during one's life. ..
  52. Autophagy and human islet amyloid polypeptide in animal models of type 2 diabetes
    Jacqueline Rivera; Fiscal Year: 2013
    ....
  53. Triple Quadrupole/Linear Ion Trap LC-MS/MS for LPI
    Jan Frederik Stevens; Fiscal Year: 2010
    ....
  54. RISK FACTORS FOR CVD IN WOMEN
    JOANN ELISABETH MANSON; Fiscal Year: 2012
    ..These promising biochemical and genetic markers may have implications for improving prevention strategies, enhancing treatment options, and generating additional testable hypotheses for heart disease research. ..
  55. Impact of Cardiovascular and Weight Loss diets on Uric Acid and Gout Risk
    Hyon K Choi; Fiscal Year: 2013
    ..With our extensive gout research experience combined with resourceful data access, we are in a unique and unparalleled position to address these key issues facing the field in the US and beyond. ..
  56. Can diet- &exercise-induced weight loss improve asthma control in obese adults?
    Jun Ma; Fiscal Year: 2013
    ..If successful, this project will help advance the current clinical guidelines for treating obese adults with asthma, which, in turn, may lead to reduced morbidity and mortality associated with asthma and obesity. ..
  57. North Carolina Birth Defects Study To Evaluate Pregnancy Exposures (NC BD-STEPS)
    Andrew Olshan; Fiscal Year: 2013
    ..By including multiple study sites, BD-STEPS will aim for a study population that is representative of the US population in racial/ethnic composition. The project period is anticipated to be 8/1/2013 - 7/31/2018. ..
  58. Translational Diebetes Prevention in GDM
    Assiamira Ferrara; Fiscal Year: 2013
    ..If this translational intervention is found to be cost-effective in this setting it should motivate changes to the health care system that would facilitate adoption of the program for all women with GDM. ..
  59. Neurotrophic Factors: Genetic Variation and Serum Levels in Brain Aging
    Sudha Seshadri; Fiscal Year: 2010
    ....
  60. Regulation of Carbohydrate Metabolism and Lipogenesis
    Kosaku Uyeda; Fiscal Year: 2013
    ..X-ray crystallography will be used to investigate the mechanisms of metabolite regulation of ChREBP binding to 14-3-3 and importin [unreadable] at an atomic level. ..
  61. Self-Determination Theory and Lifestyle Behaviors in Barrett's Esophagus Patients
    HODA J BADR; Fiscal Year: 2010
    ..Thus, the proposed project involves a relatively small investment that could yield great progress in understanding the health promotion needs of this understudied population. ..
  62. ALCOHOL AND HYPERPROLACTINEMIA
    DIPAK KUMAR SARKAR; Fiscal Year: 2013
    ..Thus, the proposed studies will provide an important clue about prenatal ethanol-induced epigenetic modifications in D2R, creating a cellular substrate vulnerable to reproductive dysfunction and pituitary tumors in adulthood. ! ..
  63. Molecular Modulation of Catalytic Sites of Escherichia coli F1Fo ATP Synthase
    Zulfiqar Ahmad; Fiscal Year: 2009
    ..A typical 70 kg human with relatively sedentary life style will generate around 2.0 million kg of ATP in a 75-year life span...
  64. Comparative effectiveness of diabetes prevention strategies in women with GDM
    Assiamira Ferrara; Fiscal Year: 2010
    ..Finding that this intervention is cost-effective in this setting should motivate its adoption at KP as well as in other health care systems. ..
  65. DETERMINANTS OF MALE AND FEMALE FECUNDITY AND FERTILITY-DATA COORDINATING CENTER
    Edward Clark; Fiscal Year: 2009
    ..It is responsive to several of NICHDs goals (viz., sequelae of reproductive health, increasing the probability of good birth outcomes, and helping to delineate the developmental origins of health disparities). ..
  66. A Cohort Study of Active and Passive Smoking in Korea
    Jonathan Samet; Fiscal Year: 2003
    ..abstract_text> ..
  67. A Pilot of Customized Continuous Care Management of Obesity in Pre-Diabetics
    Jun Ma; Fiscal Year: 2010
    ....
  68. Exploring the effect of a low-fat diet and/or exercise on change in inflammatory
    Deborah Young; Fiscal Year: 2009
    ..These results can help determine what the optimal lifestyle changes are necessary to reduce inflammation, with the ultimate goal of reducing risk for coronary heart disease. ..
  69. Cardiovascular Risk Factors and Lifestyle Modification in Breast Cancer Survivors
    Wendy Chen; Fiscal Year: 2009
    ....
  70. Incentive-Based Intervention for Smoking Cessation and Prevention in High Schools
    Suchitra Krishnan Sarin; Fiscal Year: 2010
    ..This intervention could provide a cost-effective method to reach and motivate a large number of adolescents to not use tobacco products. ..
  71. Interactive Program to Prevent Hypertension in Prehypertensive Seniors
    AMELIA BIRNEY; Fiscal Year: 2009
    ..This project will create and test an interactive lifestyle modification program tailored to the needs of prehypertensive seniors. ..
  72. A Culturally-Tailored Weight Loss Program
    Michael Simon; Fiscal Year: 2005
    ..This feasibility study should allow us to develop the methods needed to interface spirituality counseling with more traditional weight loss approaches, and this can then be tested more fully in larger and longer-term studies. ..
  73. Caloric Restriction and Aging in Humans
    John Holloszy; Fiscal Year: 2009
    ..The CR and exercise protocols will be designed on the basis of our experience, and that of the other investigators, in Phase 1. In Phase 2, the duration of the CR and exercise interventions will be two years. ..
  74. Intelligent Mobil Antiretroviral Adherence Coach
    Cheryl Gore Felton; Fiscal Year: 2009
    ..the user's physiological model can be understood and the guidance can be adapted through behavioral and life style intelligence...
  75. Unidas por la Vida: Testing a family-based intervention among high-risk Latinas
    Dara H Sorkin; Fiscal Year: 2010
    ....
  76. Impact of Lifestyle with Tumor Pathways and Microenvironment on Lymphoma Survival
    ANDREW M contact EVENS; Fiscal Year: 2010
    ..The results will provide new insights into improved disease prognostication, and ultimately lead to better treatment selection. ..
  77. Reducing Risk in Cardiac Rehabilitation: Partners Together in Health (PaTH) Inter
    Bernice Yates; Fiscal Year: 2009
    ....