Research Topics
Genomes and Genes
| ionsSummarySummary: An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS. Top Publications
Research Grants
| Scientific Experts
|
Detail Information
Publications
Reductive defluorination of perfluorooctane sulfonateValeria Ochoa-Herrera
Department of Chemical and Environmental Engineering, University of Arizona, Tucson, Arizona 85721, USA
Environ Sci Technol 42:3260-4. 2008..Chromatographic peaks corresponding to branched PFOS isomers disappeared whereas the peak corresponding to linear PFOS was stable. To our knowledge this is the first report of reductive dehalogenation of PFOS catalyzed by a biomolecule...- Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagentsPhilip L Ross
Applied Biosystems, Framingham, MA 01701, USA
Mol Cell Proteomics 3:1154-69. 2004..The derivatized peptides are indistinguishable in MS, but exhibit intense low-mass MS/MS signature ions that support quantitation... 
Metal ions in biological catalysis: from enzyme databases to general principlesClaudia Andreini
Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
J Biol Inorg Chem 13:1205-18. 2008We analysed the roles and distribution of metal ions in enzymatic catalysis using available public databases and our new resource Metal-MACiE (http://www.ebi.ac.uk/thornton-srv/databases/Metal_MACiE/home.html)...- Measurement of selected ions related to oxidative stress and energy metabolism in Saudi autistic childrenAfaf El-Ansary
Biochemistry Department, Science College, King Saud University, PO Box 22452, Zip code 11495, Riyadh, Saudi Arabia
Clin Biochem 43:63-70. 2010..This study aims to clarify the role of selected ions related to energy metabolism as a consequence of oxidative stress in the deterioration accompanied autism. 
The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ionsYuanyuan Y Wang
Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 2520, USA
J Biol Chem 283:32691-703. 2008..In conclusion, we have further clarified the mechanisms of potentiation and inactivation of TRPA1 using the D918A pore mutant, an important tool for investigating the contribution of Ca(2+) influx through TRPA1 to nociceptive signaling...- Alternate dissociation pathways identified in charge-reduced protein complex ionsKevin Pagel
University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK
Anal Chem 82:5363-72. 2010..Taken together, the results presented highlight the potential of charge state modulation as a method for directing the course of gas-phase dissociation and unfolding of protein complexes... - Effect of metal ions (Li+, Na+, K+, Mg2+, Ca2+, Ni2+, Cu2+ and Zn2+) and water coordination on the structure and properties of L-histidine and zwitterionic L-histidineMilan Remko
Department of Pharmaceutical Chemistry, Comenius University, Odbojarov 10, 832 32, Bratislava, Slovakia
Amino Acids 39:1309-19. 2010Interactions between metal ions and amino acids are common both in solution and in the gas phase. The effect of metal ions and water on the structure of L-histidine is examined... - Evidence for macromolecular protein rings in the absence of bulk waterBrandon T Ruotolo
Department of Chemistry, Lensfield Road, University of Cambridge, Cambridge CB2 1EW, UK
Science 310:1658-61. 2005.... - Excluded volume effect and orientational ordering near charged surface in solution of ions and Langevin dipolesAles Iglic
Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Trzaska 25, SI 1000 Ljubljana, Slovenia
Bioelectrochemistry 79:223-7. 2010The influence of a finite volume of ions and orientational ordering of water Langevin dipoles on the dielectric permittivity profile in the vicinity of charged surface is studied theoretically via a numerical solution of the modified .. - Ion mobility mass spectrometry of proteins and protein assembliesCharlotte Uetrecht
Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands
Chem Soc Rev 39:1633-55. 2010..to mass spectrometry providing a new dimension in the analysis of biomolecules, with ion mobility separating ions according to differences in size and shape... - RNA folding: thermodynamic and molecular descriptions of the roles of ionsDavid E Draper
Department of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, USA
Biophys J 95:5489-95. 2008The stability of a compact RNA tertiary structure is exquisitely sensitive to the concentrations and types of ions that are present... - Dynamics characterization of fully hydrated bacterial cell walls by solid-state NMR: evidence for cooperative binding of metal ionsThomas Kern
Institut de Biologie Structurale, UMR5075 CEA CNRS UJF, 38027 Grenoble, France
J Am Chem Soc 132:10911-9. 2010..We have further observed complexation with divalent ions, highlighting an important structural aspect of gram-positive cell wall architecture... - Fundamentals of traveling wave ion mobility spectrometryAlexandre A Shvartsburg
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Anal Chem 80:9689-99. 2008..The major predicted trends are in agreement with TW IMS measurements for peptide ions as a function of mobility, wave amplitude, and gas pressure... - Stable prenucleation calcium carbonate clustersDenis Gebauer
Max Planck Institute of Colloids and Interfaces, Research Campus Golm, Am Muhlenberg 1, D 14424 Potsdam, Germany
Science 322:1819-22. 2008..Huge amounts of carbon dioxide are retained as carbonate ions, and calcium ions represent a major contribution to water hardness... - Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytesFan Xia
Department of Chemistry and Biochemistry, Center for Polymers and Organic Solids, University of California, Santa Barbara, CA 93106, USA
Proc Natl Acad Sci U S A 107:10837-41. 2010..to detect a broad range of targets including nucleic acid (DNA) sequences, proteins, small molecules, and inorganic ions. This nearly "universal" biosensor approach is based on the observation that, while the conjugated .. - Ion selectivity of alpha-hemolysin with beta-cyclodextrin adapter. II. Multi-ion effects studied with grand canonical Monte Carlo/Brownian dynamics simulationsBernhard Egwolf
Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA
J Phys Chem B 114:2901-9. 2010..the potential of mean force (PMF) and characterized the self-diffusion coefficients of isolated K(+) and Cl(-) ions using molecular dynamics simulations (Y. Luo et al... - Ionomics: The functional genomics of elementsIvan Baxter
Research Computational Biologist, USDA ARS Plant Genetics, Donald Danforth Plant Sciences Center, St Louis, MO 63132, USA
Brief Funct Genomics 9:149-56. 2010..In this review, I will discuss some of the advantages and limitations of the ionomics approach as well as the important parameters to consider when designing ionomics experiments, and how to evaluate ionomics data... - Metal is not inert: role of metal ions released by biocorrosion in aseptic loosening--current conceptsDieter Cadosch
School of Anatomy and Human Biology, University of Western Australia, Crawley, Australia
J Biomed Mater Res A 91:1252-62. 2009..mechanisms of metal implant corrosion in the human body, which lead to the release of significant levels of metal ions into the peri-implant tissues and the systemic blood circulation... - High concentrations of Na+ and Cl- ions in soil solution have simultaneous detrimental effects on growth of faba bean under salinity stressEhsan Tavakkoli
School of Agriculture, Food and Wine, Waite Campus, The University of Adelaide, PMB 1, Glen Osmond, South Australia 5064, Australia
J Exp Bot 61:4449-59. 2010Despite the fact that most plants accumulate both sodium (Na(+)) and chloride (Cl(-)) ions to high concentration in their shoot tissues when grown in saline soils, most research on salt tolerance in annual plants has focused on the toxic .. - Peptide sequence scrambling through cyclization of b(5) ionsAlex G Harrison
Department of Chemistry, University of Toronto, Toronto, Canada
J Am Soc Mass Spectrom 19:1776-80. 2008The CID mass spectra of the MH(+) ions and the b(5) ions derived therefrom have been determined for the hexapeptides YAAAAA, AYAAAA, AAYAAA, AAAYAA, and AAAAYA... - A proteomics grade electron transfer dissociation-enabled hybrid linear ion trap-orbitrap mass spectrometerGraeme C McAlister
Department of Chemistry and Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA
J Proteome Res 7:3127-36. 2008..Following ion/ion reaction in the QLT, ETD product ions are mass-to-charge (m/z) analyzed in either the QLT (for speed and sensitivity) or the orbitrap (for mass .. - Salt dependence of ion transport and DNA translocation through solid-state nanoporesRalph M M Smeets
Kavli Institute of Nanoscience, Delft University of Technology, The Netherlands
Nano Lett 6:89-95. 2006..We demonstrate that the two competing effects cancel at a KCl concentration of 370 +/- 40 mM... - Semi-quantitative and structural metabolic phenotyping by direct infusion ion trap mass spectrometry and its application in genetical metabolomicsAlbert Koulman
AgResearch Grasslands Research Centre, Private Bag 11008, Palmerston North, New Zealand
Rapid Commun Mass Spectrom 23:2253-63. 2009..Of the top 100 MS(1) bins, 22 ions gave one or more reproducible QTL across the 2 years. - Brownian dynamics simulations of ion transport through the VDACKyu Il Lee
Center for Bioinformatics, University of Kansas, Lawrence, Kansas, USA
Biophys J 100:611-9. 2011..The difference in ion selectivity between the wild-type and the mutants is the result of altered potential of mean force profiles that are dominated by the electrostatic interactions... - Molecular dynamics studies of ion permeation in VDACHuan Rui
Department of Molecular Biosciences and Center for Bioinformatics, The University of Kansas, Lawrence, Kansas, USA
Biophys J 100:602-10. 2011..This difference leads to the anion selectivity of VDAC... - Relationships between growth, growth response to nutrient supply, and ion content using a recombinant inbred line population in ArabidopsisAina E Prinzenberg
Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, Cologne, Germany
Plant Physiol 154:1361-71. 2010..These lines retained over 20% more rosette weight in reduced potassium supply, accompanied by an increase in potassium content in their leaves... - Heidelberg Ion Therapy Center (HIT): Initial clinical experience in the first 80 patientsStephanie E Combs
University Hospital of Heidelberg, Department of Radiation Oncology, 69120 Heidelberg, Germany
Acta Oncol 49:1132-40. 2010..In this report we present the first 80 patients treated with proton and carbon ion radiotherapy and describe patient selection, treatment planning and daily treatment for different indications... - A new tool for tissue engineers: ions as regulators of morphogenesis during development and regenerationDANY SPENCER ADAMS
Forsyth Center for Regenerative and Developmental Biology, The Forsyth Institute, and Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
Tissue Eng Part A 14:1461-8. 2008..Biology, we are examining a different set of signals, specifically bioelectric signals (the regulated movement of ions across membranes), including membrane voltage, pH, and gap junction activity and gating... - Metals ions and neurodegenerationFrancisco Molina Holgado
Wolfson Centre for Age Related Diseases, King s College, London, UK
Biometals 20:639-54. 2007..such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review Alzheimer's disease and Parkinson's disease are mainly discussed, with the aim of identifying .. - A positive regulatory loop between foxi3a and foxi3b is essential for specification and differentiation of zebrafish epidermal ionocytesChung Der Hsiao
Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
PLoS ONE 2:e302. 2007Epidermal ionocytes play essential roles in the transepithelial transportation of ions, water, and acid-base balance in fish embryos before their branchial counterparts are fully functional... - Tuning transport properties of nanofluidic devices with local charge inversionYan He
Department of Physics and Astronomy, University of California, Irvine, Irvine, California, USA
J Am Chem Soc 131:5194-202. 2009Nanotubes can selectively conduct ions across membranes to make ionic devices with transport characteristics similar to biological ion channels and semiconductor electron devices... - Broadening of 1H NMR signals in the spectra of heparin and OSCS by paramagnetic transition metal ions. The use of EDTA to sharpen the signalsIan McEwen
Medical Products Agency, Box 26, SE 75103 Uppsala, Sweden
J Pharm Biomed Anal 51:733-5. 2010..chondroitin sulphate (OSCS) are occasionally broad or very broad owing to the presence of paramagnetic metal ions in those polysaccharides... - Silver ions induce oxidative stress and intracellular zinc release in human skin fibroblastsMiriam M Cortese-Krott
Department of Internal Medicine B, Cardiovascular Research Laboratory, Medical Faculty of the Heinrich Heine University Düsseldorf, D 40225 Dusseldorf, Germany
Free Radic Biol Med 47:1570-7. 2009..The aim of this study was to investigate whether the toxicity of silver ions, in analogy to other transition metal ions, depends on pro-oxidant effects... - Evidence for many resolvable structures within conformation types of electrosprayed ubiquitin ionsStormy L Koeniger
Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
J Phys Chem B 110:7017-21. 2006..ion mobility spectrometry approach combined with mass spectrometry has been used to examine ubiquitin ions in the gas phase... - The uptake of titanium ions by hydroxyapatite particles-structural changes and possible mechanismsCristina Castro Ribeiro
INEB Instituto de Engenharia Biomedica, Laboratorio de Biomateriais, Rua do Campo Alegre 823, Porto 4150 180, Portugal
Biomaterials 27:1749-61. 2006In order to understand the effect of titanium ions on the molecular structure of hydroxyapatite (HAp), HAp powders were incubated in solutions with different titanium concentrations... - Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrilsKarolin Klement
Leibniz Institut für Altersforschung, Beutenbergstrasse 11, D 07745 Jena, Germany
J Mol Biol 373:1321-33. 2007..One such factor affecting aggregation is the presence and concentration of salt ions. We have examined the effects of salt ions on the aggregation propensity of Alzheimer's Abeta(1-40) peptide and on .. - Formation of a wrapped DNA-protein interface: experimental characterization and analysis of the large contributions of ions and water to the thermodynamics of binding IHF to H' DNAKirk A Vander Meulen
Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
J Mol Biol 377:9-27. 2008..7+/-0.4 at constant KCl activity, indicating the net release of ca. 150 H(2)O molecules from anionic surface... - Role of chloride ions in modulation of the interaction between von Willebrand factor and ADAMTS-13Raimondo De Cristofaro
Hemostasis Research Centre, Institute of Internal Medicine and Geriatrics, Catholic University School of Medicine, Rome, Italy
J Biol Chem 280:23295-302. 2005..In this study, the role of ions on the ADAMTS-13/VWF interaction was investigated. In the presence of 1... - Stochastic binding of Ca2+ ions in the dyadic cleft; continuous versus random walk description of diffusionJohan Hake
Simula Research Laboratory, Lysaker, Norway
Biophys J 94:4184-201. 2008..We study the stochastic binding of single Ca(2+) ions to receptors in the cleft using two different models of diffusion: a stochastic and discrete Random Walk (RW) model,.. - Ionomics and the study of the plant ionomeDavid E Salt
Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907, USA
Annu Rev Plant Biol 59:709-33. 2008..In this review we describe the analytical and bioinformatics aspects of ionomics, as well as its application as a functional genomics tool... - Dimensions and ion selectivity of recombinant AMPA and kainate receptor channels and their dependence on Q/R site residuesN Burnashev
Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Heidelberg, Germany
J Physiol 496:165-73. 1996..Therefore, the differences in the anion versus cation selectivity, in Ca2+ permeability and in channel conductance are likely to be determined by the difference in charge density of the channel... - Preparing protein microarrays by soft-landing of mass-selected ionsZheng Ouyang
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
Science 301:1351-4. 2003..Deposited lysozyme and trypsin retained their biological activity. Multiply charged ions of protein kinase A catalytic subunit and hexokinase were also soft-landed into glycerol-based liquid surfaces... - Ionization and transmission efficiency in an electrospray ionization-mass spectrometry interfaceJason S Page
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
J Am Soc Mass Spectrom 18:1582-90. 2007..Current transmitted as gas-phase ions was differentiated from charged droplets and solvent clusters by measuring sensitivity with a single quadrupole .. - Where do all the ions go? The cellular basis of differential ion accumulation in leaf cellsA J Karley
Dept of Biology, University of York, PO Box 373, York, UK YO10 5YW
Trends Plant Sci 5:465-70. 2000Leaf cells accumulate solutes differently depending on their cell type. The accumulation profiles of inorganic ions have been well documented for the mesophyll and epidermis, particularly in cereals... - Molecular dynamics of a protein surface: ion-residues interactionsRan Friedman
Laser Laboratory for Fast Reactions in Biology, Department of Biochemistry, The George S. Wise Faculty for Life Sciences, Tel Aviv University, Israel
Biophys J 89:768-81. 2005..this notion was further investigated by the use of molecular dynamics simulations, where Na(+) and Cl(-) are the ions under study, thus avoiding the necessity for quantum mechanical calculations... - Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residueSiu Kwan Sze
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 1301, USA
Proc Natl Acad Sci U S A 99:1774-9. 2002..This result has been achieved with electron-capture dissociation by minimizing the further cleavage of primary product ions and by denaturing the tertiary noncovalent bonding of the molecular ions under a variety of conditions. - Detailed unfolding and folding of gaseous ubiquitin ions characterized by electron capture dissociationKathrin Breuker
Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, USA
J Am Chem Soc 124:6407-20. 2002The unfolding enthalpy of the native state of ubiquitin in solution is 5 to 8 times that of its gaseous ions, as determined by electron capture dissociation (ECD) mass spectrometry... - Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull baseStephanie E Combs
Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
Cancer 115:1348-55. 2009..The current study was conducted to evaluate the outcome of carbon ion radiotherapy (RT) in children and young adults with skull base chordomas and chondrosarcomas... - The spliceosome and its metal ionsSamuel E Butcher
Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706 1544, USA
Met Ions Life Sci 9:235-51. 2011..body of evidence indicates that the spliceosome is a magnesium-dependent enzyme that utilizes catalytic metal ions to stabilize both transition states during the two phosphoryl transfer steps of splicing... - The importance of the oxidative character of doubly charged metal cations in binding neutral bases. [Urea-M]2+ and [thiourea-M]2+ (M = Mg, Ca, Cu) complexesCristina Trujillo
Departamento de Quimica, C 9, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Phys Chem Chem Phys 10:3229-35. 2008..Hence, both [urea-Cu](2+) and [thiourea-Cu](2+) complexes can be viewed as the interaction between urea(+*) or thiourea(+*) radical cations and Cu(+)... - Systematic review and meta-analysis of radiotherapy in various head and neck cancers: comparing photons, carbon-ions and protonsBram L T Ramaekers
Department of Radiation Oncology MAASTRO, GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
Cancer Treat Rev 37:185-201. 2011..To synthesize and compare available evidence considering the effectiveness of carbon-ion, proton and photon radiotherapy for head and neck cancer... - Differentiating between fluorescence-quenching metal ions with polyfluorophore sensors built on a DNA backboneSamuel S Tan
Department of Chemistry, Stanford University, Stanford, California 94305 5080, USA
J Am Chem Soc 133:2664-71. 2011A common problem in detecting metal ions with fluorescentchemosensors is the emission-suppressing effects of fluorescence-quenching metal ions... - Molecular dynamics of ion hydration in the presence of small carboxylated molecules and implications for calcificationLaura M Hamm
Department of Geosciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
J Phys Chem B 114:10488-95. 2010.... - Metal ions: supporting actors in the playbook of small ribozymesAlexander E Johnson-Buck
Department of Chemistry, University of Michigan, 930 N University, Ann Arbor, MI 48109 1055, USA
Met Ions Life Sci 9:175-96. 2011..Nevertheless, under physiologic conditions, metal ions are essential for the proper folding and function of the small ribozymes, the most effective of these being .. - Mass spectrometric identification of proteins from silver-stained polyacrylamide gel: a method for the removal of silver ions to enhance sensitivityF Gharahdaghi
The Rockefeller University Protein DNA Technology Center, New York, NY 10021, USA
Electrophoresis 20:601-5. 1999.... - The influence of condition on permeation of Ca(II) ions from solutions of selected calcium's salts through model membraneBarbara Dolińska
Biochefa Pharmaceutical Research and Production Plant, Kasztanowa 3, Sosnowiec, Poland
Biol Trace Elem Res 140:95-102. 2011The permeation of calcium's ions from calcium solutions of fumarate, gluconate, and citrate through model membrane from the donor chamber to the acceptor chamber has been examined... - Modulation of E-cadherin monomer folding by cooperative binding of calcium ionsOlivier Courjean
Morphogenèse cellulaire et progression tumorale, Institut Curie, CNRS UMR 144, Paris, France
Biochemistry 47:2339-49. 2008Classical cadherins are transmembrane glycoproteins involved in calcium-dependent cell-cell adhesion. Calcium ions are coordinated at the interface between successive modules of the cadherin ectodomain and are thought to regulate the .. - Characterization of cardiolipin as the sodiated ions by positive-ion electrospray ionization with multiple stage quadrupole ion-trap mass spectrometryFong Fu Hsu
Mass Spectrometry Resource, Division of Endocrinology, Diabetes, Metabolism, and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Am Soc Mass Spectrom 17:1146-57. 2006..and three glycerol backbones (designated as A, B, and central glycerol, respectively), as the sodiated adduct ions in the positive-ion mode was evaluated... - Laserspray ionization, a new atmospheric pressure MALDI method for producing highly charged gas-phase ions of peptides and proteins directly from solid solutionsSarah Trimpin
Department of Chemistry, Wayne State University, Detroit, Michigan 48202 3929, USA
Mol Cell Proteomics 9:362-7. 2010..MALDI is noted for its ability to produce singly charged ions, but in the experiments described here multiply charged ions are produced by laser ablation of analyte incorporated .. - Zinc and calcium ions cooperatively modulate ADAMTS13 activityPatricia J Anderson
Howard Hughes Medical Institute, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Biol Chem 281:850-7. 2006..ADAMTS13 activity in citrate-anticoagulated plasma was enhanced approximately 2-fold by zinc ions, approximately 3-fold by calcium ions, and approximately 6-fold by both ions, suggesting cooperative activation... - Selective electrodiffusion of zinc ions in a Zrt-, Irt-like protein, ZIPBWei Lin
Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA
J Biol Chem 285:39013-20. 2010All living cells need zinc ions to support cell growth. Zrt-, Irt-like proteins (ZIPs) represent a major route for entry of zinc ions into cells, but how ZIPs promote zinc uptake has been unclear... - Langevin Poisson-Boltzmann equation: point-like ions and water dipoles near a charged surfaceEkaterina Gongadze
Institute of General Electrical Engineering, University of Rostock, Justus von Liebig Weg 2, D 18059 Rostock, Germany
Gen Physiol Biophys 30:130-7. 2011..surface is important for many biological processes such as binding of ligands to a membrane or transport of ions across it... - Ion mobility-mass spectrometry of phosphorylase B ions generated with supercharging reagents but in charge-reducing bufferChristopher J Hogan
Department of Mechanical Engineering, Yale University, USA
Phys Chem Chem Phys 12:13476-83. 2010..quot;supercharging" reagents able to shift the charge state distributions (CSDs) of electrosprayed protein ions upward also influence gas-phase protein structure... - Ionic selectivity of single nanochannelsIvan Vlassiouk
Department of Physics and Astronomy, University of California, Irvine, California 92697, USA
Nano Lett 8:1978-85. 2008..increasing interest in single nanochannel ionic devices, such as ionic filters that control the type of transported ions and ionic diodes that rectify the ionic flow... - A diadenosine 5',5''-P1P4 tetraphosphate (Ap4A) hydrolase from Arabidopsis thaliana that is activated preferentially by Mn2+ ionsBlanka Szurmak
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland
Acta Biochim Pol 55:151-60. 2008..Aided by the determination of the binding constants of Mn(Ap(4)A) and Mg(Ap(4)A) complexes using isothermal titration calorimetry (ITC) we show that AtNUDX25 preferentially hydrolyzes Ap(4)A in the form of a Mn(2+) complex... - Ion mobility mass spectrometry analysis of human glycourinomeSergey Y Vakhrushev
Institute for Medical Physics and Biophysics, Biomedical Analysis, University of Muenster, D 48149 Muenster, Germany
Anal Chem 80:2506-13. 2008..Distinct patterns of ions nested specifically by their m/z values and their drift time are observed by IMS-MS... - Ion current rectification at nanopores in glass membranesHenry S White
University of Utah, Chemistry Department, Salt Lake City, Utah 84112, USA
Langmuir 24:2212-8. 2008..of (i) the electrical screening of surface charge at high concentrations and (ii) a fixed number of charge-carrying ions in the pore at lower concentration, which are physical conditions where the voltage dependence of the conductivity .. - Sorption efficiency of chitosan nanofibers toward metal ions at low concentrationsNesrin Horzum
Department of Chemistry, Izmir Institute of Technology, Izmir, Turkey
Biomacromolecules 11:3301-8. 2010..mean of 42 nm were produced by electrospinning and utilized for the sorption of Fe(III), Cu(II), Ag(I), and Cd(II) ions from aqueous solutions... - Direct observation of triple ions in aqueous solutions of nickel(II) sulfate: a molecular link between the gas phase and bulk behaviorDetlef Schröder
Institute of Organic Chemistry and Biochemistry, vvi, Academy of Sciences of the Czech Republic, Prague, Czech Republic
J Am Chem Soc 133:2444-51. 2011..of an aqueous solution of nickel(II) sulfate provides direct experimental evidence for the formation of triple ions of the type [Ni(2)(SO(4))(H(2)O)(n)](2+) and [Ni(SO(4))(2)](2-), whose existence in aqueous solution has previously .. - Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's diseaseAnna Itkin
Laboratory of Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Universite Libre de Bruxelles, Brussels, Belgium
PLoS ONE 6:e18250. 2011..Overall, these results led us to conclude that calcium ions stimulate the formation of oligomers of Aβ(1-40), that have been implicated in the pathogenesis of AD. - Aluminium ions inhibit the formation of diacylglycerol generated by phosphatidylcholine-hydrolysing phospholipase C in tobacco cellsPremysl Pejchar
Institute of Experimental Botany, Academy of Sciences of the Czech Republic, v v i, Rozvojova 263, 165 02 Prague 6, Czech Republic
New Phytol 188:150-60. 2010Aluminium ions (Al) have been recognized as a major toxic factor for crop production in acidic soils... - Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoproteinMario A Izidoro
Departamento de Biofisica, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Tres de Maio 100, São Paulo 04044 020, Brazil
Biol Chem 391:1105-12. 2010..Using virus-derived sequences a selective activation of furin by Mg²+) ions was observed as a result of cooperativity between furin subsites... - Ion mobility-mass spectrometry analysis of isomeric carbohydrate precursor ionsMaolei Zhu
Department of Chemistry, Washington State University, Pullman, WA 99163, USA
Anal Bioanal Chem 394:1853-67. 2009The rapid separation of isomeric precursor ions of oligosaccharides prior to their analysis by mass spectrometry to the nth power (MS(n)) was demonstrated using an ambient pressure ion mobility spectrometer (IMS) interfaced with a .. - Ultrafast differential ion mobility spectrometry at extreme electric fields in multichannel microchipsAlexandre A Shvartsburg
Biological Sciences Division, Pacific Northwest National Laboratory, P O Box 999, Richland, Washington 99352, USA
Anal Chem 81:6489-95. 2009..By extending FAIMS operation into the previously inaccessible field range, the present instrument advances the capabilities for research into ion transport and expands options for separation of hard-to-resolve species... - Toxicity and uptake of iron ions by Synechocystis sp. E35 isolated from Kucukcekmece Lagoon, IstanbulSevgi Demirel
Department of Environmental Engineering, Faculty of Engineering, Harran University, 63000 Sanliurfa, Turkey
J Hazard Mater 171:710-6. 2009..Synechocystis sp. E35 adsorbed appreciable quantities of Iron ions on the cell surface within 5 min... - In vivo liberation of silver ions from metallic silver surfacesGorm Danscher
Department of Neurobiology, Institute of Anatomy, University of Aarhus, 8000, Aarhus C, Denmark
Histochem Cell Biol 133:359-66. 2010In vivo liberation of electrically charged silver atoms/silver ions from metallic silver pellets, silver grids and silver threads placed in the brain, skin and abdominal cavity was proved by way of the histochemical technique .. - Specificity of ion-protein interactions: complementary and competitive effects of tetrapropylammonium, guanidinium, sulfate, and chloride ionsPhilip E Mason
Department of Food Science, Cornell University, Ithaca, New York 14853, USA
J Phys Chem B 113:3227-34. 2009The interactions of ions with a model peptide (a single melittin alpha-helix) in solutions of tetrapropylammonium sulfate or guanidinium chloride were examined by molecular dynamics simulations... - Ultrafast differential ion mobility spectrometry at extreme electric fields coupled to mass spectrometryAlexandre A Shvartsburg
Biological Sciences Division, Pacific Northwest National Laboratory, P O Box 999, Richland, Washington 99352, USA
Anal Chem 81:8048-53. 2009..5 mm gaps. Since the separation speed scales as E4 to E6, these chips filter ions in just approximately 20 micros (or approximately 100-10,000 times faster than "macroscopic" designs), .. - Effects of dissolucytotic gold ions on recovering brain lesionsGorm Danscher
Department of Anatomy and Neurobiology, University of Aarhus, 8000, Aarhus C, Denmark
Histochem Cell Biol 133:367-73. 2010..has shown that metallic gold releases charged gold atoms when placed intracerebrally and that the liberated gold ions affect inflammation in the brain... - High-resolution differential ion mobility separations using helium-rich gasesAlexandre A Shvartsburg
Biological Sciences Division, Pacific Northwest National Laboratory, P O Box 999, Richland, Washington 99352, USA
Anal Chem 82:2456-62. 2010Analyses of complex mixtures and characterization of ions increasingly involve gas-phase separations by ion mobility spectrometry (IMS) and particularly differential or field asymmetric waveform IMS (FAIMS) based on the difference of ion .. - Copper ions regulate cytotoxicity of disulfiram to myeloid leukemia cellsJarmila Navrátilová
Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
Int J Mol Med 24:661-70. 2009..Simple addition of copper can resume sensitivity of high-density leukemic cells to DSF and improve efficiency of anti-leukemic therapies using this drug, thus providing benefit to patients with high WBC count... - Recent significant developments in detection and method development for the determination of inorganic ions by CECameron Johns
Australian Centre for Research on Separation Science, School of Chemistry, University of Tasmania, Hobart, Tasmania, Australia
Electrophoresis 30:S53-67. 2009..It is shown that C4D provides considerably superior detection sensitivity (by a factor of about 8 in comparison with optimised indirect photometry)... - Systemic levels of metallic ions released from orthodontic mini-implantsLiliane Siqueira de Morais
Mechanical and Aerospace Engineering Department, University of California, San Diego, USA
Am J Orthod Dentofacial Orthop 135:522-9. 2009Orthodontic mini-implants are a potential source of metallic ions to the human body because of the corrosion of titanium (Ti) alloy in body fluids... - Interactions of mono- and divalent metal ions with aspartic and glutamic acid investigated with IR photodissociation spectroscopy and theoryJeremy T O'Brien
Department of Chemistry, University of California, Berkeley, California 94720 1460, USA
J Phys Chem A 112:10823-30. 2008The interaction of metal ions with aspartic (Asp) and glutamic (Glu) acid and the role of gas-phase acidity on zwitterionic stability were investigated using infrared photodissociation spectroscopy in the spectral range 950-1900 cm (-1) .. - Hydration and hydrodynamic interactions of lysozyme: effects of chaotropic versus kosmotropic ionsAvanish S Parmar
Department of Physics, University of South Florida, Tampa, Florida 33620, USA
Biophys J 97:590-8. 2009..we have investigated the effects of either strongly chaotropic, nearly neutral or strongly kosmotropic salt ions on the hydration shell and the mutual hydrodynamic interactions of the protein lysozyme under conditions supportive .. - Binding of calcium ions to Ras promotes Ras guanine nucleotide exchange under emulated physiological conditionsJun Ming Liao
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
Biochim Biophys Acta 1784:1560-9. 2008..Together, these results indicate that binding of calcium ions to H-Ras remarkably promotes H-Ras guanine nucleotide exchange under emulated physiological conditions... - Oxidative stability of egg and soy lecithin as affected by transition metal ions and pH in emulsionGuang Wang
Department of Food Science and Human Nutrition, Iowa State University, Ames, 50011 1061, USA
J Agric Food Chem 56:11424-31. 2008Oxidative stability of egg and soy lecithin in emulsion was evaluated with two transition metal ions, cupric and ferric ion, at two concentration levels (50 and 500 microM)... - Rhythmic fluctuations in the concentration of intracellular Mg2+ in association with spontaneous rhythmic contraction in cultured cardiac myocytesKoichi Kawahara
Laboratory of Cellular Cybernetics, Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan
Chronobiol Int 25:868-81. 2008Magnesium ions (Mg(2+)) play a fundamental role in cellular function, but the cellular dynamic changes of intracellular Mg(2+) remain poorly delineated... - Free zinc ions outside a narrow concentration range are toxic to a variety of cells in vitroRebecca A Bozym
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N Greene Street, Baltimore, MD 21201, USA
Exp Biol Med (Maywood) 235:741-50. 2010..Zinc ions are a required nutrient but elevated concentrations are known to kill cells in vitro... - Overtone mobility spectrometry: part 1. Experimental observationsRuwan T Kurulugama
Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
J Am Soc Mass Spectrom 20:729-37. 2009..Unlike conventional ion mobility instruments that use an electrostatic gate to introduce a packet of ions into a drift region, the present approach uses multiple segmented drift regions with modulated drift fields to .. - Overtone mobility spectrometry: part 2. Theoretical considerations of resolving powerStephen J Valentine
Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
J Am Soc Mass Spectrom 20:738-50. 2009The transport of ions through multiple drift regions is modeled to develop an equation that is useful for an understanding of the resolving power of an overtone mobility spectrometry (OMS) technique... - Effect of negative air ions on the potential for bacterial contamination of plastic medical equipmentSimon J Shepherd
Bradford Infection Group, School of Engineering, Design and Technology, University of Bradford, Bradford BD71DP, UK
BMC Infect Dis 10:92. 2010..control the spread of infection in hospitals and a number of researchers have investigated the biocidal action of ions in both air and nitrogen... - Role of racemization in optically active drugs developmentImran Ali
Department of Chemistry, Faculty of Natural Sciences, Jamia Millia Islamia University, Jamia Nagar, New Delhi, India
Chirality 19:453-63. 2007..e. pH, temperature, concentration of the drug, ionic concentration, etc. Attempts have also been made to discuss the mechanisms of racemization. Besides, efforts have been made to suggest the safe dosages of such type of drugs too... - Electrokinetic and adsorption properties of sepiolite modified by 3-aminopropyltriethoxysilaneOzkan Demirbaş
Balikesir University, Faculty of Science and Literature, Department of Chemistry, 10145 Balikesir, Turkey
J Hazard Mater 149:650-6. 2007..The utility of the 3-APT-modified sepiolite was investigated as an adsorbent for removal of various heavy metal ions such as Fe, Mn, Co, Zn, Cu, Cd and Ni from aqueous solutions... - Enzymatic hydrolysis of penicillin in mixed ionic liquids/water two-phase systemYangyang Jiang
Laboratory of Separation Science and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Science, Beijing 100080, China
Biotechnol Prog 23:829-35. 2007..As a result, the removal of the two products from the enzyme sphere at relatively high pH is permitted in MILWS, which is beneficial for enzymatic activity and stability in comparison with the acidic pH 4 environment in BAWS... - Vesicle aggregation in aqueous mixtures of negatively charged polyelectrolyte and conventional cationic surfactantJingxia Yao
Beijing National Laboratory for Molecular Science BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
J Colloid Interface Sci 314:523-30. 2007Vesicle aggregation induced by different environmental factors, including the addition of divalent metal ions, decrease of pH, and increase of temperature--was investigated through turbidity measurement, fluorescence measurement, and .. - Sorption characteristics of Cu(II) ions onto silica gel-immobilized calix[4]arene polymer in aqueous solutions: batch and column studiesMustafa Tabakci
Selcuk University, Department of Chemical Engineering, 42075 Konya, Turkey
J Hazard Mater 151:331-8. 2008..14 mg/g. The Thomas and the Yoon-Nelson models were applied to experimental data to predict the breakthrough curves and to determine the characteristics parameters of the column useful for process design... - Probing surface structures of Shewanella spp. by microelectrophoresisEtienne Dague
Laboratoire de Chimie Physique et Microbiologie pour l'Environnement, UMR 7564, CNRS, UHP Nancy I, , France
Biophys J 90:2612-21. 2006..It is clearly shown how the peculiar surface structures of the bacteria investigated are reflected in their electrohydrodynamic properties... - Influence of ionic interactions on the photoinduced birefringence of poly[1-[4-(3-carboxy-4 hydroxyphenylazo) benzene sulfonamido]-1,2-ethanediyl, sodium salt] filmsQuirina Ferreira
CEFITEC, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829 516 Caparica, Portugal
J Nanosci Nanotechnol 7:2659-66. 2007..with poly(allylamine hydrochloride) (PAH), the electrostatic interactions between the oppositely charged polymers hampered photoisomerization and molecular rearrangement, thus leading to a slower writing kinetics for highly charged.. - Ab initio studies of aspartic acid conformers in gas phase and in solutionMingliang Chen
Hefei National Laboratory for Physical Sciences at Microscale, Department of Physics, University of Science and Technology of China, Hefei, Anhui 230026, China
J Chem Phys 127:154314. 2007..The studies show that combining aspartic acid with at least six water molecules in the gas phase or two water molecules and a SCRF solution model is required to provide qualitatively correct results in the solution... - Effect of aluminum (III) on the conversion of dopachrome in the melanin synthesis pathwayJunwei Di
Department of Chemistry, Nanjing University, Nanjing 210093, People's Republic of China
Spectrochim Acta A Mol Biomol Spectrosc 59:1689-96. 2003The effect of aluminum ions on the kinetics and mode of the conversion of dopachrome (DC) in acidic environment has been studied using UV-Vis spectrophotometric and cyclic voltammetric methods...
Research Grants
- MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic StrokeRobert Knight; Fiscal Year: 2009..Injury to the BBB in ischemic stroke often leads to the leakage of ions, water, amino acids, and plasma proteins into the brain and as a result in large strokes significant brain swelling ..
- Individual Predoctoral Dental Scientist FellowshipMelissa Talbert; Fiscal Year: 2007..This degradative process releases metal ions, which stimulate fibrous tissue formation, leading to impairment of osseointegration and implant failure...
- Monovalent metal ion binding sites in nucleic acidsSCOTT STROBEL; Fiscal Year: 2004..Metal ions act as essential cofactors in the folding of RNAs...
- FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASEBharati Mitra; Fiscal Year: 2007P1B-type ATPases transport soft metal ions across membranes. These pumps maintain homeostasis of essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
- Structural Basis for Bridged Bimetallic Enzyme CatalysisDagmar Ringe; Fiscal Year: 2009More than half of all proteins contain metal ions. A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a carboxylate group)...
- Structural Basis for Bridged Bimetallic Enzyme CatalysisDagmar Ringe; Fiscal Year: 2007More than half of all proteins contain metal ions. A large percentage of those contain two metal ions (usually first-row transition metals or magnesium) connected by a bridging ligand (usually a carboxylate group)...
- STRUCTURE OF NA+/K+ ATPASEROBERT FARLEY; Fiscal Year: 2000..The Na,K-ATPase couples the hydrolysis of intracellular ATP to the transport of Na+ ions out of cells and K+ ions into cells, thereby participating in the mechanism of fluid and electrolyte balance in ..
- STRUCTURE OF NA+/K+ ATPASEROBERT FARLEY; Fiscal Year: 1993..The Na,K-ATPase couples the hydrolysis of intracellular ATP to the transport of Na+ ions out of cells and K+ ions into cells, thereby participating in the mechanism of fluid and electrolyte balance in ..
- FUNCTIONAL ANALYSIS OF A LEAD/CADMIUM/ZINC ATPASEBharati Mitra; Fiscal Year: 2010P1B-type ATPases transport soft metal ions across membranes. These pumps maintain homeostasis of essential trace metals like copper, zinc, cobalt and nickel, and mediate resistance to toxic metals such as lead, cadmium and silver...
- Carcinogenesis of Nickel and Epigenetic ControlMax Costa; Fiscal Year: 2007..The affinity constant of nickel ions binding to this JmjC facial triad is predicted to be at least 3 orders of magnitude greater than that of Fe...
- Carcinogenesis of Nickel and Epigenetic ControlMax Costa; Fiscal Year: 2010..The affinity constant of nickel ions binding to this JmjC facial triad is predicted to be at least 3 orders of magnitude greater than that of Fe...
- NMR STUDIES OF CYTOSOLIC METAL IONS AND OXIDATIVE STRESSRaj Gupta; Fiscal Year: 2006Our long-range goal is to elucidate the role of intracellular mineral ions (Na+, K+, free Mg2+ & free Ca2+) and oxidative stress in the pathophysiology of essential hypertension and type 2 diabetes...
- Computational Suite for RNA-Targeted Drug DesignErin Duffy; Fiscal Year: 2005..We aim to extend and validate computational methods and protocols for treating accurately the interactions among RNA, ions and ligands...
- Microvascular Regulation During Intestinal AbsorptionHAROLD BOHLEN; Fiscal Year: 2007..As sodium enters the cell, it is removed in exchange for calcium ions by the sodium/calcium exchanger...
- Catalytic DNA Biosensor for Toxic Metal IonsYi Lu; Fiscal Year: 2005..DNA biosensors for on-site, real-time, and cost-effective detection and quantification of multiple heavy metal ions, such as mercury, cadmium and lead, simultaneously will be explored...
- Molecular mechanisms of potassium channel permeation and gatingCRINA MARIA NIMIGEAN; Fiscal Year: 2010..KcsA selectivity using a multidisciplinary three-pronged approach: 1) electrophysiology of KcsA block by impermeant ions using analysis of single- channel current recordings, 2) X-ray crystallography of the blocked KcsA channels, and 3) ..
- ELECTRON MONOCHROMATOR TIME-OF-FIGHT MASS SPECTROMETERMax Deinzer; Fiscal Year: 2002The interaction of low-energy electrons with electrophilic molecules in the production of negative ions is an important chemical process...
- Molecular Physiology of CLC Chloride ChannelsTsung Yu Chen; Fiscal Year: 2010..Ion channels help transport ions into and out of the cell, and thus play important roles in many physiological functions...
- Molecular Physiology of CLC Chloride ChannelsTsung Yu Chen; Fiscal Year: 2010..Ion channels help transport ions into and out of the cell, and thus play important roles in many physiological functions...