chromates

Summary

Summary: Salts of chromic acid containing the CrO(2-)4 radical.

Top Publications

  1. ncbi Modeling chromate reduction in Shewanella oneidensis MR-1: development of a novel dual-enzyme kinetic model
    Sridhar Viamajala
    Department of Chemical Engineering, WSU/NSF IGERT Center for Multiphase Environmental Research, Washington State University, P.O. Box 642719, Pullman, WA 99164-2719, USA
    Biotechnol Bioeng 83:790-7. 2003
  2. ncbi Chromate-reducing properties of soluble flavoproteins from Pseudomonas putida and Escherichia coli
    D F Ackerley
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Appl Environ Microbiol 70:873-82. 2004
  3. ncbi ChrR, a soluble quinone reductase of Pseudomonas putida that defends against H2O2
    Claudio F Gonzalez
    Department of Microbiology and Immunology, Sherman Fairchild Science Building, Stanford University School of Medicine, California 94305, USA
    J Biol Chem 280:22590-5. 2005
  4. ncbi Mechanism of chromate reduction by the Escherichia coli protein, NfsA, and the role of different chromate reductases in minimizing oxidative stress during chromate reduction
    D F Ackerley
    Department of Microbiology and Immunology, Sherman Fairchild Science Building, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA
    Environ Microbiol 6:851-60. 2004
  5. ncbi Effect of chromate stress on Escherichia coli K-12
    D F Ackerley
    Department of Microbiology and Immunology, Sherman Fairchild Science Building, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA
    J Bacteriol 188:3371-81. 2006
  6. ncbi A bacterial flavin reductase system reduces chromate to a soluble chromium(III)-NAD(+) complex
    Geoffrey J Puzon
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4234, USA
    Biochem Biophys Res Commun 294:76-81. 2002
  7. ncbi Expression of chromate resistance genes from Shewanella sp. strain ANA-3 in Escherichia coli
    Esther Aguilar-Barajas
    Department of Soil, Water, and Environmental Science, University of Arizona, Tucson, AZ 85721, USA
    FEMS Microbiol Lett 285:97-100. 2008
  8. ncbi Chromate reduction by a pseudomonad isolated from a site contaminated with chromated copper arsenate
    J McLean
    Department of Microbiology, College of Biological Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Appl Environ Microbiol 67:1076-84. 2001
  9. ncbi Microsatellite instability and protein expression of the DNA mismatch repair gene, hMLH1, of lung cancer in chromate-exposed workers
    Yuji Takahashi
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima City, Japan
    Mol Carcinog 42:150-8. 2005
  10. ncbi Global molecular and morphological effects of 24-hour chromium(VI) exposure on Shewanella oneidensis MR-1
    Karuna Chourey
    Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    Appl Environ Microbiol 72:6331-44. 2006

Research Grants

  1. Particulate Cr(VI) Toxicology in Human Lung Epithelial Cells and Fibroblasts
    John Wise; Fiscal Year: 2009
  2. Uptake and Mutagenicity of Moderately Soluble Hexavalent Chromium
    DIANE STEARNS; Fiscal Year: 2007
  3. MECHANISM OF PARTICULATE CHROMATE CARCINOGENESIS
    Steven Patierno; Fiscal Year: 1993
  4. Chromium Genotoxicity: Response and Repair Mechanisms
    Steven Patierno; Fiscal Year: 2007
  5. PARTICULATE CHROMIUM TOXICITY AND CARCINOGENESIS
    Steven Patierno; Fiscal Year: 2003
  6. Toxiology of Particulate Cr(VI)in Human Lung Cells
    John Wise; Fiscal Year: 2005
  7. Particulate Cr(VI) Toxicology in Human Lung Epithelial Cells and Fibroblasts
    John Pierce Wise; Fiscal Year: 2010
  8. Particulate Cr(VI) Toxicology in Human Lung Epithelial Cells and Fibroblasts
    John Pierce Wise; Fiscal Year: 2010
  9. WTC Dust Size and Alkalinity as Factors in First Responder Chronic Lung Ailments
    Mitchell Cohen; Fiscal Year: 2009
  10. Chemical Mapping of Chromate Uptake, Localization, and Reduction in Remediating B
    Joseph Irudayaraj; Fiscal Year: 2009

Detail Information

Publications169 found, 100 shown here

  1. ncbi Modeling chromate reduction in Shewanella oneidensis MR-1: development of a novel dual-enzyme kinetic model
    Sridhar Viamajala
    Department of Chemical Engineering, WSU/NSF IGERT Center for Multiphase Environmental Research, Washington State University, P.O. Box 642719, Pullman, WA 99164-2719, USA
    Biotechnol Bioeng 83:790-7. 2003
    ..Kinetic parameters were estimated by fitting experimental data, and model fits were found to correspond very closely to quantitative observations of Cr(VI) reduction by MR-1...
  2. ncbi Chromate-reducing properties of soluble flavoproteins from Pseudomonas putida and Escherichia coli
    D F Ackerley
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Appl Environ Microbiol 70:873-82. 2004
    ..The results nevertheless suggest that YieF may be an even more suitable candidate for further studies than ChrR...
  3. ncbi ChrR, a soluble quinone reductase of Pseudomonas putida that defends against H2O2
    Claudio F Gonzalez
    Department of Microbiology and Immunology, Sherman Fairchild Science Building, Stanford University School of Medicine, California 94305, USA
    J Biol Chem 280:22590-5. 2005
    ....
  4. ncbi Mechanism of chromate reduction by the Escherichia coli protein, NfsA, and the role of different chromate reductases in minimizing oxidative stress during chromate reduction
    D F Ackerley
    Department of Microbiology and Immunology, Sherman Fairchild Science Building, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA
    Environ Microbiol 6:851-60. 2004
    ..We previously showed that ChrR protects Pseudomonas putida against chromate toxicity; here we show that NfsA or YieF overproduction can also increase the tolerance of E. coli to this compound...
  5. ncbi Effect of chromate stress on Escherichia coli K-12
    D F Ackerley
    Department of Microbiology and Immunology, Sherman Fairchild Science Building, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA
    J Bacteriol 188:3371-81. 2006
    ....
  6. ncbi A bacterial flavin reductase system reduces chromate to a soluble chromium(III)-NAD(+) complex
    Geoffrey J Puzon
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4234, USA
    Biochem Biophys Res Commun 294:76-81. 2002
    ....
  7. ncbi Expression of chromate resistance genes from Shewanella sp. strain ANA-3 in Escherichia coli
    Esther Aguilar-Barajas
    Department of Soil, Water, and Environmental Science, University of Arizona, Tucson, AZ 85721, USA
    FEMS Microbiol Lett 285:97-100. 2008
    ..The chrR gene from the P. aeruginosa chromosome was necessary for full chromate resistance conferred by chrA. A diminished chromate uptake in cells expressing the chrA gene suggests that chromate resistance is due to chromate efflux...
  8. ncbi Chromate reduction by a pseudomonad isolated from a site contaminated with chromated copper arsenate
    J McLean
    Department of Microbiology, College of Biological Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Appl Environ Microbiol 67:1076-84. 2001
    ..Chromate reduction under both aerobic and anaerobic conditions may be a detoxification strategy for the bacterium which could be exploited to bioremediate chromate-contaminated or other toxic heavy metal-contaminated environments...
  9. ncbi Microsatellite instability and protein expression of the DNA mismatch repair gene, hMLH1, of lung cancer in chromate-exposed workers
    Yuji Takahashi
    Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima City, Japan
    Mol Carcinog 42:150-8. 2005
    ..039). The inactivation of hMLH1 expression strongly correlated with the microsatellite high instability phenotype in chromate lung cancer. The genetic instability of chromate lung cancer is due to the repression of hMLH1 protein...
  10. ncbi Global molecular and morphological effects of 24-hour chromium(VI) exposure on Shewanella oneidensis MR-1
    Karuna Chourey
    Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    Appl Environ Microbiol 72:6331-44. 2006
    ....
  11. ncbi Frequent microsatellite instability in lung cancer from chromate-exposed workers
    Toshiyuki Hirose
    Second Department of Surgery, School of Medicine, University of Tokushima, Tokushima, Japan
    Mol Carcinog 33:172-80. 2002
    ..In addition to our previous study of p53 mutations, the present findings suggest that the carcinogenic mechanism of chromate lung cancer may differ from that of non-chromate lung cancer...
  12. ncbi Formation of soluble organo-chromium(III) complexes after chromate reduction in the presence of cellular organics
    Geoffrey J Puzon
    School of Molecular Biosciences, Center for Multiphase Environmental Research, and Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164, USA
    Environ Sci Technol 39:2811-7. 2005
    ..Thus, organo-Cr(III) complexes may account for the mobile form of Cr(II) detected in the environment...
  13. ncbi Dosage-dependent proteome response of Shewanella oneidensis MR-1 to acute chromate challenge
    Melissa R Thompson
    Graduate School of Genome Science and Technology, Oak Ridge National Laboratory University of Tennessee Knoxville, Tennessee 37830, USA
    J Proteome Res 6:1745-57. 2007
    ..The results presented in this work demonstrate the dynamic dosage response of S. oneidensis to sub-toxic levels of chromate...
  14. ncbi Reduction of chromate by cell-free extract of Brucella sp. isolated from Cr(VI) contaminated sites
    Urvashi Thacker
    Post Graduate Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar 388 120, Gujarat, India
    Bioresour Technol 98:1541-7. 2007
    ..High Cr(VI) concentration resistance and high Cr(VI) reducing ability of the strain make it a suitable candidate for bioremediation...
  15. ncbi Efflux of chromate by Pseudomonas aeruginosa cells expressing the ChrA protein
    Betzabe E Pimentel
    , Universidad Michoacana, Edificio B-3, Ciudad Universitaria, 58030 Morelia, Mich, Mexico
    FEMS Microbiol Lett 212:249-54. 2002
    ..Inhibition of chromate extrusion by valinomycin, nigericin, and carbonyl cyanide m-chlorophenylhydrazone, but not by oligomycin or dicyclohexylcarbodiimide, indicated that chromate efflux was driven by the membrane potential...
  16. ncbi Essential residues in the chromate transporter ChrA of Pseudomonas aeruginosa
    Selene Aguilera
    , Universidad Michoacana, Edificio B-3, Ciudad Universitaria, 58030 Morelia, Mich, Mexico
    FEMS Microbiol Lett 232:107-12. 2004
    ..PhoA and LacZ translational fusions were used to confirm the membrane topology at the N-terminal half of the ChrA protein...
  17. ncbi Bioremediation of chromate: thermodynamic analysis of the effects of Cr(VI) on sulfate-reducing bacteria
    B Chardin
    , Institut de Biologie Structurale et Microbiologie - CNRS, 31 Ch. Joseph Aiguier, 13009 Marseille, France
    Appl Microbiol Biotechnol 60:352-60. 2002
    ..The study by microcalorimetry of heavy metal effects on SRB bioenergetic metabolism thus appears an appropriate tool to identify better strains to be used for industrial bioremediation process development...
  18. ncbi New genes involved in chromate resistance in Ralstonia metallidurans strain CH34
    Susanne Juhnke
    , , Kurt-Mothes-Strasse 3, 06099 Halle, Germany, European Community
    Arch Microbiol 179:15-25. 2002
    ..Thus, possible regulators for chromate resistance (ChrI, ChrB(1), ChrB(2), ChrF(1), and ChrF(2)) and an additional detoxification system (ChrC) were newly identified as parts of chromate resistance in R. metallidurans...
  19. ncbi Membrane topology of the chromate transporter ChrA of Pseudomonas aeruginosa
    Rafael Jiménez-Mejía
    Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana, Morelia, Mich, Mexico
    FEMS Microbiol Lett 262:178-84. 2006
    ..These data also suggest that the two halves of ChrA may carry out distinct functions for the transport of chromate...
  20. ncbi Phylogenetic analysis of the chromate ion transporter (CHR) superfamily
    César Díaz Pérez
    Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana, Morelia, Michoacan, Mexico
    FEBS J 274:6215-27. 2007
    ....
  21. ncbi Heavy metal tolerance and metal homeostasis in Pseudomonas putida as revealed by complete genome analysis
    David Canovas
    Centro Nacional de Biotecnologia CSIC, Campus de Cantoblanco, 28049 Madrid, Spain
    Environ Microbiol 5:1242-56. 2003
    ..Some of the metal-related clusters are located in gene islands with atypical genome signatures. The predicted capacity of P. putida to endure exposure to heavy metals is discussed from an evolutionary perspective...
  22. ncbi Chromate reduction by Burkholderia cepacia MCMB-821, isolated from the pristine habitat of alkaline crater lake
    Revati Wani
    Biochemistry Division, Department of Chemistry, University of Pune, Ganeshkhind, Pune, 411007, India
    Appl Microbiol Biotechnol 75:627-32. 2007
    ..The chromate-reducing ability of MCMB-821 was suppressed in the presence of membrane inhibitors and enhanced in the presence of 2,4-dinitrophenol, suggesting the involvement of electron transport chain in the Cr(VI) bioreduction...
  23. ncbi Chromate reduction and 16S rRNA identification of bacteria isolated from a Cr(VI)-contaminated site
    P Pattanapipitpaisal
    School of Biosciences, The University of Birmingham, Edgbaston, England
    Appl Microbiol Biotechnol 57:257-61. 2001
    ..At a concentration of 2.4x10(9) cells/ml, 100 microM sodium chromate was reduced within 30 h; however, the maximum specific reduction rate was obtained at lower initial cell concentrations...
  24. ncbi Short-chain chromate ion transporter proteins from Bacillus subtilis confer chromate resistance in Escherichia coli
    Amada Díaz-Magaña
    Instituto de Investigaciones Quimico Biologicas, Universidad Michoacana, Morelia, Michoacan
    J Bacteriol 191:5441-5. 2009
    ..These results suggest that short-chain CHR proteins form heterodimer transporters which efflux chromate ions from the cytoplasm...
  25. ncbi A putative azoreductase gene is involved in the Shewanella oneidensis response to heavy metal stress
    Irina Mugerfeld
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907, USA
    Appl Microbiol Biotechnol 82:1131-41. 2009
    ..In addition, the rate of extracellular chromate disappearance by the deletion strain was initially impaired, although both the so3585 mutant and MR-1 wild type reduced Cr(VI) within the same time period...
  26. ncbi CHR, a novel family of prokaryotic proton motive force-driven transporters probably containing chromate/sulfate antiporters
    D H Nies
    Institut fur Mikrobiologie, D 06099 Halle, Germany
    J Bacteriol 180:5799-802. 1998
    ..CHR proteins occur in bacteria and archaea. They consist of about 400 amino acyl residues, appear to have 10 transmembrane alpha-helical segments in an unusual 4+6 arrangement, and arose by an intragenic duplication event...
  27. ncbi Global proteomic analysis of the chromate response in Arthrobacter sp. strain FB24
    Kristene L Henne
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Proteome Res 8:1704-16. 2009
    ..These results are consistent with the growth defects seen with strain FB24 when Cr(VI) concentrations exceeded 5 mM...
  28. ncbi Comparative temporal proteomics of a response regulator (SO2426)-deficient strain and wild-type Shewanella oneidensis MR-1 during chromate transformation
    Karuna Chourey
    Environmental Sciences Division, Oak Ridge National Laboratory, Tennessee 37831, USA
    J Proteome Res 8:59-71. 2009
    ..In addition, the proteome data sets were mined for amino acids with potential post-translational modifications (PTMs) indicative of a level of gene expression regulation extending beyond the transcriptional control imposed by SO2426...
  29. ncbi Nucleotide sequence and expression of a plasmid-encoded chromate resistance determinant from Alcaligenes eutrophus
    A Nies
    Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago 60680
    J Biol Chem 265:5648-53. 1990
    ....
  30. ncbi The chromate-inducible chrBACF operon from the transposable element TnOtChr confers resistance to chromium(VI) and superoxide
    Rita Branco
    Laboratorio de Microbiologia, Departmento de Bioquimica, Universidade de Coimbra, 3001 517 Coimbra, Portugal
    J Bacteriol 190:6996-7003. 2008
    ..The presence of three genes protecting against superoxide toxicity should provide an additional survival advantage to TnOtChr-containing cells in the environments with multiple redox-active contaminants...
  31. ncbi Transcriptome analysis reveals response regulator SO2426-mediated gene expression in Shewanella oneidensis MR-1 under chromate challenge
    Karuna Chourey
    Department of Biological Sciences, Purdue University, 915 W, State Street, West Lafayette, IN 47907, USA
    BMC Genomics 9:395. 2008
    ..To delineate the cellular function of SO2426 and its contribution to metal stress response, we integrated genetic and physiological approaches with a genome-wide screen for target gene candidates comprising the SO2426 regulon...
  32. ncbi Enzyme improvement in the absence of structural knowledge: a novel statistical approach
    Yoram Barak
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    ISME J 2:171-9. 2008
    ..Thus, the statistical model underlying the experiment was validated, and its predictions were shown to reduce laboratory labor and resources...
  33. ncbi Molecular dynamics of the Shewanella oneidensis response to chromate stress
    Steven D Brown
    Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
    Mol Cell Proteomics 5:1054-71. 2006
    ....
  34. ncbi Chromium oxidation state imaging in mammalian cells exposed in vitro to soluble or particulate chromate compounds
    Richard Ortega
    Laboratoire de Chimie Nucléaire Analytique et Bioenvironnementale, Centre National de la Recherche Scientifique CNRS, Universite de Bordeaux 1, BP 120, Chemin du Solarium, 33175 Gradignan, France
    Chem Res Toxicol 18:1512-9. 2005
    ..The possible stronger carcinogenicity of low solubility chromate vs soluble chromate compounds may derive from the combinative genotoxic effects of intranuclear Cr(III) and the persistent exposure to a strong oxidant, Cr(VI)...
  35. ncbi Interindividual variability in response to sodium dichromate-induced oxidative DNA damage: role of the Ser326Cys polymorphism in the DNA-repair protein of 8-oxo-7,8-dihydro-2'-deoxyguanosine DNA glycosylase 1
    Amanda J Lee
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:497-505. 2005
    ..In conclusion, the homozygous Cys(326) genotype may represent a biomarker of individual susceptibility of lung cancer risk in individuals that are occupationally exposed to CrVI...
  36. ncbi Lead ions do not cause human lung cells to escape chromate-induced cytotoxicity
    Amie L Holmes
    Wise Laboratory of Environmental and Genetic Toxicology, Bioscience Research Institute, University of Southern Maine, Portland, ME 04104-9300, USA
    Toxicol Appl Pharmacol 203:167-76. 2005
    ..These data indicate that Cr ions caused the cytotoxicity. We found that lead chromate and soluble Cr (VI) induced similar amounts of cytotoxicity indicating that Pb does not play an epigenetic role and cause Cr-damaged cells to survive...
  37. ncbi Aerobic chromate reduction by chromium-resistant bacteria isolated from serpentine soil
    Arundhati Pal
    Microbiology Laboratory, Department of Botany, University of Calcutta, Kolkata 700 019, India
    Microbiol Res 159:347-54. 2004
    ..Experiments with cell-free extracts indicated that the soluble fraction of the cell was responsible for aerobic reduction of Cr(VI) by this organism...
  38. ncbi The clastogenic effects of chronic exposure to particulate and soluble Cr(VI) in human lung cells
    Amie L Holmes
    Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, 96 Falmouth Street, Portland, ME 04104-9300, United States
    Mutat Res 610:8-13. 2006
    ....
  39. ncbi Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure
    Daryl E Pritchard
    The George Washington University Medical Center, Washington, DC 20037, USA
    Mol Cell Biochem 279:169-81. 2005
    ..Selection of cells with altered expression of these genes may constitute the early stages of tumour progression...
  40. ncbi Chromate reduction capability of a gram positive bacterium isolated from effluent of dying industry
    S Sultan
    Department of Botany, University of the Punjab, Lahore, Pakistan
    Bull Environ Contam Toxicol 75:699-706. 2005
  41. ncbi Lead chromate-induced chromosome damage requires extracellular dissolution to liberate chromium ions but does not require particle internalization or intracellular dissolution
    Hong Xie
    Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, 96 Falmouth Street, P.O. Box 9300, Portland, Maine 04104-9300, USA
    Chem Res Toxicol 17:1362-7. 2004
    ..Pathology studies indicate that chromates target cells at bronchial bifurcation sites in human lungs...
  42. ncbi Oxidative activation of the human carcinogen chromate by arsenite: a model for synergistic metal activation leading to oxidative DNA damage
    Kent D Sugden
    Department of Chemistry, The University of Montana, 32 Campus Drive, Missoula, MT 59812, USA
    Toxicol In Vitro 18:741-8. 2004
    ..Further, these data demonstrate the utility of the DCF fluorescence assay as a sensitive method for screening synergistic redox interactions in metal mixtures...
  43. ncbi XRCC1 protects against particulate chromate-induced chromosome damage and cytotoxicity in Chinese hamster ovary cells
    Eliza Grlickova-Duzevik
    Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, 04104-9300, USA
    Toxicol Sci 92:409-15. 2006
    ..In addition, XRCC1 deficiency resulted in a dramatic increase in the number of chromatid exchanges, indicating that XRCC1 is involved in protection from lead chromate-induced chromosome instability...
  44. ncbi Comparison between acetic acid and landfill leachates for the leaching of Pb(II), Cd(II), As(V), and Cr(VI) from cementitious wastes
    Cheryl E Halim
    Centre for Particle and Catalyst Technologies, School of Chemical Engineering and Industrial Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia
    Environ Sci Technol 38:3977-83. 2004
    ..It was also found that the presence of carbonates in the municipal landfill leachate affected the stability of calcium arsenate, with the carbonate competing with arsenate for calcium at high pH, forcing arsenate into the solution...
  45. ncbi Beneficial role of hydrophytes in removing Cr(VI) from wastewater in association with chromate-reducing bacterial strains Ochrobactrum intermedium and Brevibacterium
    Muhammad Faisal
    Department of Botany, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan
    Int J Phytoremediation 7:271-7. 2005
    ..Nevertheless, the bacterial strains caused some decrease in chromate uptake into the plants, but the combined effect of plants and bacterial strains conduce more removal of Cr(VI) from the solution...
  46. ncbi Hexavalent chromium induced changes in growth and biochemical responses of chromate-resistant bacterial strains isolated from tannery effluent
    O P Shukla
    Ecotoxicology and Bioremediation Group, National Botanical Research Institute, Rana Pratap Marg, Lucknow 226 001, India
    Bull Environ Contam Toxicol 77:96-103. 2006
  47. ncbi Differential impact of ionic and coordinate covalent chromium (Cr)-DNA binding on DNA replication
    Jamie L Fornsaglio
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC 20037, USA
    Mol Cell Biochem 279:149-55. 2005
    ..Thus, these results suggest that treatment of living cells with Cr(VI) leads to two modes of Cr-binding, which may have conflicting effects on DNA replication...
  48. ncbi Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells
    Hong Xie
    Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, 96 Falmouth St, P.O. Box 9300, Portland, ME 04104-9300, USA
    Mutat Res 586:160-72. 2005
    ..X (r-H2A.X) foci formation with 0.1, 0.5, 1, 5 and 10 microg/cm2 lead chromate inducing a relative increase in the number of cells with r-H2A.X foci formation of 43, 51, 115 and 129%, respectively...
  49. ncbi Chromate removal by an iron sorbent: mechanism and modeling
    Edward Smith
    Department of Construction Engineering, The American University, Cairo, Egypt
    Water Environ Res 78:84-93. 2006
    ..5 +/- 0.3 mg/g was achieved at exhaustion. Predictive model runs indicate that, for this case, an EBCT of 2.0 to 2.5 minutes is optimum for achieving a target effluent concentration of less than or equal to 0.05 mg/L chromium as Cr(VI)...
  50. ncbi Anaerobic co-reduction of chromate and nitrate by bacterial cultures of Staphylococcus epidermidis L-02
    A Vatsouria
    Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, pr Nauki 5, 142290, Pushchino, Russia
    J Ind Microbiol Biotechnol 32:409-14. 2005
    ..0 micromol Cr 10(10 )cells(-1 )h(-1) at 20 degrees C. The maximum specific rate was as high as 8.8-9.8 micromol Cr 10(10 )cells(-1 )h(-1). The role of nitrate in chromate reduction is discussed...
  51. ncbi Bacterial Cr(VI) reduction concurrently improves sunflower (Helianthus Annuus L.) growth
    Muhammad Faisal
    Department of Botany, University of the Punjab, Quaid-e-Azam Campus, 54590 Lahore, Pakistan
    Biotechnol Lett 27:943-7. 2005
    ..O. intermedium caused 30% decrease in chromium uptake in sunflower plant roots under Cr(VI) stress as compared to chromium-free control plants...
  52. ncbi Prevention of chromate induced oxidative stress by alpha-lipoic acid
    Roli Budhwar
    Environmental Carcinogenesis Section, Industrial Toxicology Research Center, Post Box 80, MG Marg, Lucknow 226001, UP, India
    Indian J Exp Biol 43:531-5. 2005
    ..An improved status of the tissue antioxidants by LA appeared to be the mechanism of mitigation. The results are of chemopreventive value and suggest a possible alternative to ascorbic acid for abrogation of Cr toxicity...
  53. ncbi Lower mutagenicity but higher stability of Cr-DNA adducts formed during gradual chromate activation with ascorbate
    George Quievryn
    Department of Pathology and Laboratory Medicine, Brown University, 70 Ship Street, Room 507, Providence RI 02912, USA
    Carcinogenesis 27:2316-21. 2006
    ..Overall, our findings do not support the possibility that increased Cr(V) formation at depleted ascorbate levels modeling heavy dose exposures causes higher levels of mutagenic DNA damage...
  54. ncbi Human lung cell growth is not stimulated by lead ions after lead chromate-induced genotoxicity
    Sandra S Wise
    Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, Maine 04104-9300, USA
    Mol Cell Biochem 279:75-84. 2005
    ..Previously we have shown that particulate chromates dissolve extracellularly releasing chromium (Cr) and lead (Pb) ions and only the Cr ions induce genotoxicity...
  55. ncbi Particulate and soluble hexavalent chromium are cytotoxic and genotoxic to human lung epithelial cells
    Sandra S Wise
    Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, University of Southern Maine, PO Box 9300, Portland, ME 04103-9300, United States
    Mutat Res 610:2-7. 2006
    ..Ten micromolar sodium chromate induced profound cell cycle delay and no metaphases were found. Overall the data clearly indicate that hexavalent Cr(VI) is cytotoxic and genotoxic to human lung epithelial cells...
  56. ncbi Reductive activation of Cr(Vi) by nitric oxide synthase
    Ryan Porter
    Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Chem Res Toxicol 18:834-43. 2005
    ..Thus, reduction of Cr(VI) to Cr(V) by NOS occurs in resting and fully active states. It is likely that the reaction between Cr(V) and superoxide influences the cytotoxic mechanisms of Cr(VI) in cells...
  57. ncbi Lung cancer mortality in the German chromate industry, 1958 to 1998
    Thomas Birk
    ENVIRON Germany GmbH, Essen, Germany
    J Occup Environ Med 48:426-33. 2006
    ..We conducted a mortality study of two German chromate production facilities and evaluated possible dose-response relationships between hexavalent chromium exposure and lung cancer...
  58. ncbi Chromate ion adsorption by agricultural by-products modified with dimethyloldihydroxyethylene urea and choline chloride
    Lynda H Wartelle
    USDA ARS Southern Regional Research Center, 1100 Robert E Lee Blvd, P O Box 19687, New Orleans, LA 70179 0687, USA
    Water Res 39:2869-76. 2005
    ..DMDHEU/choline chloride modification of the three by-products produced an anion exchange resin with a high capacity to adsorb chromate ion singly or competitively in the presence of other anions from aqueous solutions...
  59. ncbi Effect of lead and chromium on reproductive success of Japanese quail
    D Butkauskas
    Institute of Ecology of Vilnius University, Akademijos 2, LT 08412 Vilnius 21, Lithuania
    Environ Toxicol 19:412-5. 2004
    ..In general, hatchability, fertility, embryonic mortality and reproductive success of Japanese quail were dependent on age, sex, genotypes, and on single or binary treatment with the inorganic salts of lead and chromium...
  60. ncbi Comparison of in vitro Cr(VI) reduction by CFEs of chromate resistant bacteria isolated from chromate contaminated soil
    Abhipsa Sarangi
    Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600 036, India
    Bioresour Technol 99:4130-7. 2008
    ..Activity enhancement by Cu(2+) was more predominant (290%) for KCH4. The characterization of Cr(VI) reduction by CFEs of chromate resistant isolates of different genera is useful for development of Cr(VI) bioremediation...
  61. ncbi Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest
    Linan Ha
    Department of Pharmacology, Program in Molecular and Cellular Oncology, The George Washington University Medical Center, Washington, D C 20037, USA
    J Biol Chem 278:17885-94. 2003
    ..The results also strongly suggest that terminal growth arrest is not merely an extended or even irreversible form of checkpoint arrest, but instead an independent and unique cell fate pathway...
  62. ncbi Reductive activation of hexavalent chromium by human lung epithelial cells: generation of Cr(V) and Cr(V)-thiol species
    Griselda R Borthiry
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Inorg Biochem 102:1449-62. 2008
    Chromium(VI) compounds (e.g. chromates) are cytotoxic, mutagenic, and potentially carcinogenic. The reduction of Cr(VI) can yield reactive intermediates such as Cr(V) and reactive oxygen species...
  63. ncbi Hexavalent chromium causes the oxidation of thioredoxin in human bronchial epithelial cells
    Judith M Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Toxicology 246:222-33. 2008
    Hexavalent chromium [Cr(VI)] species such as chromates are cytotoxic...
  64. ncbi Temporal decrease of trivalent chromium concentration in a standardized algal culture medium: experimental results and implications for toxicity evaluation
    Davide A L Vignati
    University of Geneva Institut F A Forel, Versoix, 1290, Switzerland
    Bull Environ Contam Toxicol 80:305-10. 2008
    ..Monitoring of the temporal variability of Cr(III) concentrations in algal culture media appears necessary to better characterize the toxicity of trivalent chromium to algae...
  65. ncbi The cytotoxicity and genotoxicity of particulate and soluble hexavalent chromium in human lung cells
    John Pierce Wise
    Laboratory of Environmental and Genetic Toxicology, Department of Epidemiology and Public Health, Division of Environmental Health Sciences, Yale University, School of Medicine, P O Box 208034, New Haven, CT 06520 8034, USA
    Mutat Res 517:221-9. 2002
    ..Na(2)CrO(4) (5 and 10 microM) induced such profound cell cycle delay that no metaphases were found. Overall the data clearly indicate that Cr(VI) compounds are cytotoxic and genotoxic to human lung cells...
  66. ncbi Induction of apoptosis in the lung but not in the liver of rats receiving intra-tracheal instillations of chromium(VI)
    Francesco D'Agostini
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 23:587-93. 2002
    ..Therefore, apoptosis is likely to provide a protective mechanism at a post-genotoxic stage of Cr(VI) carcinogenesis...
  67. ncbi Chromium(VI) induced alterations in mouse spleen cells: a short-term assay
    R P das Neves
    Departamento de Biologia, Universidade de Aveiro, Portugal
    Cytobios 106:27-34. 2001
    ..Changes included enlargement of the capsule and depletion of the red pulp cells, accompanied by an increase in macrophages, 24 h after injection. Partial restoration of red pulp was noted after 48 h...
  68. ncbi The effects of chromium VI on the fitness and on the beta-tubulin genes during in vivo development of the nematode Steinernema feltiae
    Stephen Boyle
    Molecular Ecology and Nematode Research Group, Department of Science and Health, Institute of Technology Carlow, Kilkenny Road, Carlow, Ireland
    Sci Total Environ 404:56-67. 2008
    ..These findings constitute this organism appropriate for further investigation for the development of sub-lethal end points and biomarkers for the detection and biomonitoring of chromium VI contamination in soil...
  69. ncbi Analytical speciation of chromium in in-vitro cultures of chromate-resistant filamentous fungi
    Francisco Javier Acevedo Aguilar
    Instituto de Investigaciones Cientificas, Universidad de Guanajuato, L de Retana N degrees 5, 36000, Guanajuato, Mexico
    Anal Bioanal Chem 392:269-76. 2008
    ....
  70. ncbi Microscopic investigations of the Cr(VI) uptake mechanism of living Ochrobactrum anthropi
    Bin Li
    State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China
    Langmuir 24:9630-5. 2008
    ..This work also proved that the control of Cr immobilization by living Ochrobactrum anthropi could be achieved via adjusting the bacterial culture medium...
  71. ncbi Chromate concentration bias in primer paint particles
    P T LaPuma
    Air Force Institute of Technology, Wright-Patterson AFB, Ohio, 45433, USA
    Regul Toxicol Pharmacol 33:343-9. 2001
    ....
  72. ncbi Chromate resistance, transport and bioreduction by Exiguobacterium sp. ZM-2 isolated from agricultural soil irrigated with tannery effluent
    Mohammad Zubair Alam
    Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh, India
    J Basic Microbiol 48:416-20. 2008
    ..ZM-2 readily reduce Cr (VI) to Cr (III). The kinetics of chromate reductase fit well in the linearized Lineweaver-Burk plot and showed a K(m) of 106.1 microM Cr (VI) and V(max) of 1.24 micromol/min per mg of protein...
  73. ncbi Chromate reduction by waste iron from electroplating wastewater using plug flow reactor
    Shiao Shing Chen
    Institute of Environmental Engineering and Management, National Taipei University of Technology, No 1, Section 3, Chung Hsiao East Road, Taipei 106, Taiwan
    J Hazard Mater 152:1092-7. 2008
    ..X-ray diffraction was conducted to examine the remaining species. Other than chromium oxide and hydroxide species, an iron-chromium complex (Cr2FeO4) was also observed...
  74. ncbi Kinetics and structural constraints of chromate reduction by green rusts
    Deborah L Bond
    Department of Geological and Environmental Sciences, Stanford University, Stanford, California 94305-2115, USA
    Environ Sci Technol 37:2750-7. 2003
    ..The mole fraction of Fe(III) in the Cr(x),Fe(1-x)(OH)3 x nH2O reaction product ranged from 17% to 68%, leading to a highly stabilized (low solubility) phase...
  75. ncbi Hexavalent chromium exposures during full-aircraft corrosion control
    Gary N Carlton
    72nd Medical Group, Tinker AFB, OK, USA
    AIHA J (Fairfax, Va) 64:668-72. 2003
    ..In addition, mechanical abrasion of aircraft surfaces can generate particulates that contain chromates from previously applied primers and conversion coats...
  76. ncbi Potential hazards of hexavalent chromate in our drinking water
    Max Costa
    Department of Environmental Medicine, Department of Pharmacology, NYU Cancer Institute, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Toxicol Appl Pharmacol 188:1-5. 2003
    ..This treatise has been inspired by recent reviews and speculations that suggest that we may safely drink hexavalent Cr in great excess of the current EPA and states drinking water standards of 50-100 ppb...
  77. ncbi Reduction of chromate from electroplating wastewater from pH 1 to 2 using fluidized zero valent iron process
    Shiao Shing Chen
    Institute of Environmental Engineering and Management, National Taipei University of Technology, No 1, Sec 3, Chung Hsiao E Rd, Taipei 106, Taiwan
    J Hazard Mater 142:362-7. 2007
    ..X-ray diffraction (XRD) was conducted to exam the remained species at pH 2. ZVI, iron oxide and iron sulfide were observed, indicating the formation of iron oxide or iron sulfide could stop the chromate reduction reaction...
  78. ncbi Hexavalent chromium removal in vitro and from industrial wastes, using chromate-resistant strains of filamentous fungi indigenous to contaminated wastes
    Francisco Javier Acevedo-Aguilar
    , Universidad de Guanajuato,
    Can J Microbiol 52:809-15. 2006
    ..These results indicate that chromate-resistant filamentous fungi with Cr(VI)-reducing capability could be useful for the removal of Cr(VI) contamination...
  79. ncbi Chromium is the proximate clastogenic species for lead chromate-induced clastogenicity in human bronchial cells
    Sandra S Wise
    Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland 04104-9300, USA
    Mutat Res 560:79-89. 2004
    ..These data indicate that with respect to LC-induced clastogenicity, Cr and not Pb is the proximate clastogenic species in human lung cells...
  80. ncbi Human nucleotide excision repair efficiently removes chromium-DNA phosphate adducts and protects cells against chromate toxicity
    Mindy Reynolds
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 279:30419-24. 2004
    ....
  81. ncbi Cr(VI) reduction in a chromate-resistant strain of Candida maltosa isolated from the leather industry
    Rocío Ramírez-Ramírez
    Instituto de Investigacion en Biologia Experimental, Facultad de Quimica, Guanajuato 36000, Guanajuato, Mexico
    Antonie Van Leeuwenhoek 85:63-8. 2004
    ..NADH-dependent chromate reductase activity was found associated with soluble protein and, to a lesser extent, with the membrane fraction...
  82. ncbi Chromate sorption and reduction kinetics onto an aminated biosorbent
    S Deng
    Department of Environmental Science and Engineering, Tsinghua University, Beijing, China, 100084
    Water Sci Technol 54:1-8. 2006
    ..The reduced Cr(III) ions formed some aggregates on the surface at higher solution pHs...
  83. ncbi Ku80 deficiency does not affect particulate chromate-induced chromosome damage and cytotoxicity in Chinese hamster ovary cells
    Eric Camyre
    Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, ME 04104 9300, USA
    Toxicol Sci 97:348-54. 2007
    ..The spectrum of chromosome damage was also unaffected by Ku80 deficiency. These data indicate that Ku80 protects cells from cytotoxicity but is not involved in protecting cells from particulate chromate-induced CIN...
  84. ncbi Telomerase-mediated lifespan extension of human bronchial cells does not affect hexavalent chromium-induced cytotoxicity or genotoxicity
    Sandra S Wise
    Laboratory of Environmental and Genetic Toxicology, Department of Epidemiology and Public Health, Division of Environmental Health Sciences, Yale University School of Medicine, New Haven, CT, USA
    Mol Cell Biochem 255:103-11. 2004
    ....
  85. ncbi X-ray absorption spectroscopic and electrochemical studies of tris(catecholato(2-))chromate(V/IV/III) complexes
    Aviva Levina
    Centre for Heavy Metals Research, School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia
    Angew Chem Int Ed Engl 43:462-5. 2004
  86. ncbi Barium chromate is cytotoxic and genotoxic to human lung cells
    Sandra S Wise
    Center for Integrated and Applied Environmental Toxicology, Wise Laboratory of Environmental and Genetic Toxicology, Bioscience Research Institute, University of Southern Maine, Portland, Maine 04104-9300, USA
    Environ Mol Mutagen 42:274-8. 2003
    ..Overall the data indicate that BC is cytotoxic and genotoxic to human lung cells...
  87. ncbi Safety of trivalent chromium complexes: no evidence for DNA damage in human HaCaT keratinocytes
    Isabelle Hininger
    Laboratoire Nutrition, Vieillissement, Maladies Cardiovasculaires, EA 3746, J Fourier University, Domaine de la Merci, 38700 La Tronche, France
    Free Radic Biol Med 42:1759-65. 2007
    ..These data further support the low toxicity of trivalent Cr complexes used in nutrient supplements...
  88. ncbi Detection of anions by normal Raman spectroscopy and surface-enhanced Raman spectroscopy of cationic-coated substrates
    P A Mosier-Boss
    SPAWAR Systems Center San Diego, Code 236, San Diego, California 92152, USA
    Appl Spectrosc 57:1129-37. 2003
    ..A competitive complexation method was used to evaluate the interaction of chloride ion with the cationic coatings. Hydrogen bonding and pi-pi interactions play significant roles in the selectivity of the cationic coatings...
  89. ncbi Occupational allergic contact dermatitis in Singapore
    D Ko
    Department of Community, Occupational and Family Medicine, Faculty of Medicine MD3, National University of Singapore, Singapore
    Sci Total Environ 270:97-101. 2001
    ..The main occupational contact allergens were chromates, nickel, rubber chemicals, cutting fluids and resins...
  90. ncbi Influence of coating bath chemistry on the deposition of 3-mercaptopropyl trimethoxysilane films deposited on magnesium alloy
    A F Scott
    Dept of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada P3E 2C6
    J Colloid Interface Sci 343:474-83. 2010
    ..Many of the current pretreatments/coatings available use toxic chemicals such as chromates and hydrofluoric acid...
  91. ncbi Occupational contact dermatitis in the UK: a surveillance report from EPIDERM and OPRA
    J D Meyer
    Centre for Occupational and Environmental Health, University of Manchester, UK
    Occup Med (Lond) 50:265-73. 2000
    ..2), epoxies and other resins (15.6), aromatic amines (8.6), chromium and chromates (8.1), fragrances and cosmetics (8.0), and preservatives (7.3). Soaps (22.0% of cases), wet work (19...
  92. ncbi Contact sensitizer potassium dichromate alters lymphocyte populations in draining lymph nodes and blood in mice
    Kohji Aoyama
    Department of Environmental Medicine, Kagoshima University School of Medicine, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    Toxicol Mech Methods 17:475-81. 2007
    ABSTRACT Chromium is a common human contact allergen, but it is not known whether chromates cause contact hypersensitivity by immunological mechanisms similar to those induced by strong haptens...
  93. ncbi Environmental biochemistry of chromium
    M E Losi
    Department of Soil and Environmental Sciences, University of California, Riverside 92521
    Rev Environ Contam Toxicol 136:91-121. 1994
    ..The environmental behavior of Cr is largely a function of its oxidation state. Hexavalent Cr compounds (mainly chromates and dichromates) are considered toxic to a variety of terrestrial and aquatic organisms and are mobile in soil/..
  94. ncbi Electron energy loss spectroscopy elucidates the elusive darkening of zinc potassium chromate in Georges Seurat's A Sunday on La Grande Jatte-1884
    F Casadio
    Conservation Department, The Art Institute of Chicago, Chicago, IL, 60603, USA
    Anal Bioanal Chem 399:2909-20. 2011
    ..demonstrated that the equilibrium between chromate and dichromate ions is reversible within the paint film and that the orange dichromate ions can be transformed back into bright yellow chromates by exposure to highly alkaline gases.
  95. ncbi Removal of Cr(VI) and As(V) from aqueous solutions by HDTMA-modified zeolite Y
    Alias Mohd Yusof
    Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia
    J Hazard Mater 162:1019-24. 2009
    ..The highest chromates and arsenates adsorption efficiency was observed from solutions of pH values 3 and 8, respectively because of ..
  96. ncbi The pro-oxidant chromium(VI) inhibits mitochondrial complex I, complex II, and aconitase in the bronchial epithelium: EPR markers for Fe-S proteins
    Charles R Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 49:1903-15. 2010
    Hexavalent chromium (Cr(VI)) compounds (e.g., chromates) are strong oxidants that readily enter cells, where they are reduced to reactive Cr species that also facilitate reactive oxygen species generation...
  97. ncbi The intracellular redox stress caused by hexavalent chromium is selective for proteins that have key roles in cell survival and thiol redox control
    Judith M Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Toxicology 281:37-47. 2011
    Hexavalent chromium [Cr(VI)] compounds (e.g. chromates) are strong oxidants that readily enter cells where they are reduced to reactive Cr intermediates that can directly oxidize some cell components and can promote the generation of ..
  98. ncbi [Most frequent causes of allergic contact dermatitis in farmers: based on material collected in the Nofer Institute of Occupational Medicine, Lodz]
    Marta Kiec-Swierczynska
    Przychodni Chorób Zawodowych, Instytutu Medycyny Pracy im prof J Nofera w Łodzi
    Med Pr 54:237-43. 2003
    ..examinations, in a group of 132 farmers with suspected occupational disease, contact allergy induced by metals (chromates, nickel, cobalt, mercury), disinfectants and their components (formaldehyde, glutaraldehyde, quaternary ammonium ..
  99. ncbi The effects of hexavalent chromium on thioredoxin reductase and peroxiredoxins in human bronchial epithelial cells
    Judith M Myers
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Free Radic Biol Med 47:1477-85. 2009
    Inhalational exposure to hexavalent chromium (Cr(VI)) compounds (e.g., chromates) is of concern in many Cr-related industries and their surrounding environments. The bronchial epithelium is directly exposed to inhaled Cr(VI)...
  100. ncbi Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium
    Laura M Beaver
    Department of Pharmacology and Physiology, The George Washington University Medical Center, 2300 I Street NW, Washington, DC 20037, USA
    Toxicol Appl Pharmacol 235:47-56. 2009
    ..however the immediate (0-24 h) pathologic injury and immune responses after exposure to particulate chromates have not been adequately investigated...
  101. ncbi Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis
    Dongsoon Bae
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC, USA
    Mutat Res 660:40-6. 2009
    ..were treated with Cr(VI) (as Na(2)CrO(4)), the soluble oxyanionic dissolution product of certain particulate chromates, which are well-documented human respiratory carcinogens...

Research Grants55

  1. Particulate Cr(VI) Toxicology in Human Lung Epithelial Cells and Fibroblasts
    John Wise; Fiscal Year: 2009
    Hexavalent chromium (Cr(VI)) or chromate is a major public health concern. Chromates, particularly the insoluble compounds, are well-established human lung carcinogens...
  2. Uptake and Mutagenicity of Moderately Soluble Hexavalent Chromium
    DIANE STEARNS; Fiscal Year: 2007
    ..paradigm proposes that the chromate compounds that are moderately water-soluble are more carcinogenic than the chromates that are either insoluble or water-soluble; however, it is not understood why this is so...
  3. MECHANISM OF PARTICULATE CHROMATE CARCINOGENESIS
    Steven Patierno; Fiscal Year: 1993
    ..mechanisms which determine the carcinogenic action of environmentally and occupationally important colloidal chromates. Using PbCrO4 as a prototype insoluble particulars chromate we will examine the relationship of particle size ..
  4. Chromium Genotoxicity: Response and Repair Mechanisms
    Steven Patierno; Fiscal Year: 2007
    ..This research will help elucidate the molecular mechanisms of chromium toxicity and carcinogenesis and will have practical value in contributing to the evaluation of risk to humans in contact with chromates.
  5. PARTICULATE CHROMIUM TOXICITY AND CARCINOGENESIS
    Steven Patierno; Fiscal Year: 2003
    ..This research will help to elucidate molecular mechanisms of chromium toxicity and carcinogenesis and will have practival value in contributing to the evaluation of risk to humans exposed to chromates.
  6. Toxiology of Particulate Cr(VI)in Human Lung Cells
    John Wise; Fiscal Year: 2005
    ..abstract_text> ..
  7. Particulate Cr(VI) Toxicology in Human Lung Epithelial Cells and Fibroblasts
    John Pierce Wise; Fiscal Year: 2010
    Hexavalent chromium (Cr(VI)) or chromate is a major public health concern. Chromates, particularly the insoluble compounds, are well-established human lung carcinogens...
  8. Particulate Cr(VI) Toxicology in Human Lung Epithelial Cells and Fibroblasts
    John Pierce Wise; Fiscal Year: 2010
    Hexavalent chromium (Cr(VI)) or chromate is a major public health concern. Chromates, particularly the insoluble compounds, are well-established human lung carcinogens...
  9. WTC Dust Size and Alkalinity as Factors in First Responder Chronic Lung Ailments
    Mitchell Cohen; Fiscal Year: 2009
    ....
  10. Chemical Mapping of Chromate Uptake, Localization, and Reduction in Remediating B
    Joseph Irudayaraj; Fiscal Year: 2009
    ..The knowledge gained from this novel study will contribute to the development of scientifically grounded strategies for improving bioremediation efficacy. ..
  11. Human Lung Chromium Toxicity: Role of cytochrome b5
    Charles Myers; Fiscal Year: 2007
    ..They will provide a deeper understanding of the mechanisms underlying Cr(VI) toxicity in human lung, and will lead to new insights on the role of b5 in toxicant activation ..
  12. Oxidative DNA Lesion Formation from Chromate Exposure
    KENT SUGDEN; Fiscal Year: 2007
    ..This research will also serve to identify novel biomarkers of Cr(VI) exposure and suggest repair genes that can be analyzed for polymorphisms and mutations. ..
  13. WTC Dust Size and Alkalinity as Factors in First Responder Chronic Lung Ailments
    Mitchell D Cohen; Fiscal Year: 2010
    ....
  14. Oxidative DNA Lesion Formation from Chromate Exposure
    Kent D Sugden; Fiscal Year: 2010
    ..This research will also serve to identify novel biomarkers of Cr(VI) exposure and suggest repair genes that can be analyzed for polymorphisms and mutations. ..
  15. Chemical Mapping of Chromate Uptake, Localization, and Reduction in Remediating B
    JOSEPH MK IRUDAYARAJ; Fiscal Year: 2010
    ..The knowledge gained from this novel study will contribute to the development of scientifically grounded strategies for improving bioremediation efficacy. ..
  16. Oxidative DNA Lesion Formation from Chromate Exposure
    KENT SUGDEN; Fiscal Year: 2009
    ..This research will also serve to identify novel biomarkers of Cr(VI) exposure and suggest repair genes that can be analyzed for polymorphisms and mutations. ..
  17. Multiplex arrays using Confocal Raman for BRCA1 alternative splice profiling
    Joseph Irudayaraj; Fiscal Year: 2007
    ....
  18. OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTION
    Charles Myers; Fiscal Year: 2002
    ..They will also contribute to environmental health by expanding our knowledge on the mechanisms by which manganese, iron, and various heavy metals are mobilized into water supplies. ..
  19. OXIDATIVE MECHANISMS IN CHROMIUM CARCINOGENESIS
    KENT SUGDEN; Fiscal Year: 2003
    ..Understanding these mechanisms may allow reduction of risk to exposed human populations. ..
  20. Properties of Metals May Govern Toxicities in the Lungs
    Mitchell Cohen; Fiscal Year: 2006
    ..By establishing if certain properties of metals are more relevant to toxicity than others, this may provide Investigators a needed basis to preempt use of some metal ions/complexes in metallopharmaceuticals. ..