korsakoff syndrome

Summary

Summary: An acquired cognitive disorder characterized by inattentiveness and the inability to form short term memories. This disorder is frequently associated with chronic ALCOHOLISM; but it may also result from dietary deficiencies; CRANIOCEREBRAL TRAUMA; NEOPLASMS; CEREBROVASCULAR DISORDERS; ENCEPHALITIS; EPILEPSY; and other conditions. (Adams et al., Principles of Neurology, 6th ed, p1139)

Top Publications

  1. ncbi The Korsakoff syndrome: clinical aspects, psychology and treatment
    Michael D Kopelman
    King s College London, Institute of Psychiatry, London, UK
    Alcohol Alcohol 44:148-54. 2009
  2. ncbi Cholinergic parameters and the retrieval of learned and re-learned spatial information: a study using a model of Wernicke-Korsakoff Syndrome
    Rita G W Pires
    Departamento de Bioquímica Imunologia, Laboratório de Neurociência e Comportamento, Universidade Federal de Minas Gerais, Belo Horizonte 31270 010, Brazil
    Behav Brain Res 162:11-21. 2005
  3. ncbi Mechanisms of selective neuronal cell death due to thiamine deficiency
    K Todd
    Neuroscience Research Unit, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    Ann N Y Acad Sci 893:404-11. 1999
  4. ncbi Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management
    GianPietro Sechi
    Institute of Clinical Neurology, University of Sassari, Italy
    Lancet Neurol 6:442-55. 2007
  5. ncbi Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
    Ed Day
    Department of Psychiatry, Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK
    Cochrane Database Syst Rev 7:CD004033. 2013
  6. ncbi Functional MRI study of diencephalic amnesia in Wernicke-Korsakoff syndrome
    M Caulo
    Department of Clinical Sciences and Bio imaging, University G D Annunzio, Chieti Pescara, Italy
    Brain 128:1584-94. 2005
  7. ncbi Aging potentiates the acute and chronic neurological symptoms of pyrithiamine-induced thiamine deficiency in the rodent
    S R Pitkin
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, NY 13905, USA
    Behav Brain Res 119:167-77. 2001
  8. ncbi Wernicke-Korsakoff syndrome associated with hyperemesis gravidarum
    Chang Kyoon Yoon
    Department of Ophthalmology, Dankook University College of Medicine, Cheonan, Korea
    Korean J Ophthalmol 19:239-42. 2005
  9. pmc Stage-dependent alterations of progenitor cell proliferation and neurogenesis in an animal model of Wernicke-Korsakoff syndrome
    Ryan P Vetreno
    Department of Psychology, Behavioral Neuroscience, State University of New York at Binghamton, Vestal, NY 13902, USA
    Brain Res 1391:132-46. 2011
  10. pmc The role of cholinergic and GABAergic medial septal/diagonal band cell populations in the emergence of diencephalic amnesia
    J J Roland
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University, State University of New York, Binghamton, NY 13902, USA
    Neuroscience 160:32-41. 2009

Research Grants

  1. Hippocampus/Pituitary Ratio: an AD Brain Injury Marker?
    Thomas Beresford; Fiscal Year: 2005
  2. IMPAIRED AND PRESERVED MEMORY PROCESSES IN AMNESIA
    Mieke Verfaellie; Fiscal Year: 2007
  3. BRAIN-INJURY MEMORY DISORDERS RESEARCH CENTER
    Mieke Verfaellie; Fiscal Year: 2003
  4. Brain Tissue Resource Centre for Alcohol Research
    Clive Harper; Fiscal Year: 2007
  5. The Role of Acetylcholine Dysfunction in Diencephalic Amnesia
    Lisa M Savage; Fiscal Year: 2010
  6. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2008
  7. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    EDITH VIONI SULLIVAN; Fiscal Year: 2010
  8. Alcoholism risk and protective factors in Trinidad
    Cindy Ehlers; Fiscal Year: 2006
  9. Neurobehavioral Consequences of Adolescent Alcohol
    Cindy Ehlers; Fiscal Year: 2008
  10. ADOLESCENT MARIJUANA USE IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2008

Detail Information

Publications187 found, 100 shown here

  1. ncbi The Korsakoff syndrome: clinical aspects, psychology and treatment
    Michael D Kopelman
    King s College London, Institute of Psychiatry, London, UK
    Alcohol Alcohol 44:148-54. 2009
    The Korsakoff syndrome is a preventable memory disorder that usually emerges (although not always) in the aftermath of an episode of Wernicke's encephalopathy...
  2. ncbi Cholinergic parameters and the retrieval of learned and re-learned spatial information: a study using a model of Wernicke-Korsakoff Syndrome
    Rita G W Pires
    Departamento de Bioquímica Imunologia, Laboratório de Neurociência e Comportamento, Universidade Federal de Minas Gerais, Belo Horizonte 31270 010, Brazil
    Behav Brain Res 162:11-21. 2005
    ..But the correlation with the behavioural parameters was observed only for pre-trained animals, that is, those that were retrained and assessed for retrograde retention...
  3. ncbi Mechanisms of selective neuronal cell death due to thiamine deficiency
    K Todd
    Neuroscience Research Unit, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    Ann N Y Acad Sci 893:404-11. 1999
    ..Recent evidence of early microglial activation and increased free radical production suggest that oxidative stress processes play an important early role in the brain damage associated with thiamine deficiency...
  4. ncbi Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management
    GianPietro Sechi
    Institute of Clinical Neurology, University of Sassari, Italy
    Lancet Neurol 6:442-55. 2007
    ..A systematic approach helps to ensure that patients receive a prompt diagnosis and adequate treatment...
  5. ncbi Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
    Ed Day
    Department of Psychiatry, Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK
    Cochrane Database Syst Rev 7:CD004033. 2013
    Autopsy studies suggest that Wernicke-Korsakoff syndrome (WKS) is not a rare disorder, particularly in individuals who abuse alcohol...
  6. ncbi Functional MRI study of diencephalic amnesia in Wernicke-Korsakoff syndrome
    M Caulo
    Department of Clinical Sciences and Bio imaging, University G D Annunzio, Chieti Pescara, Italy
    Brain 128:1584-94. 2005
    Anterograde amnesia in Wernicke-Korsakoff syndrome is associated with diencephalic lesions, mainly in the anterior thalamic nuclei. Whether diencephalic and temporal lobe amnesias are distinct entities is still not clear...
  7. ncbi Aging potentiates the acute and chronic neurological symptoms of pyrithiamine-induced thiamine deficiency in the rodent
    S R Pitkin
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, NY 13905, USA
    Behav Brain Res 119:167-77. 2001
    ..advanced age in the development and manifestation of thiamine deficiency using an animal model of Wernicke-Korsakoff syndrome (WKS)...
  8. ncbi Wernicke-Korsakoff syndrome associated with hyperemesis gravidarum
    Chang Kyoon Yoon
    Department of Ophthalmology, Dankook University College of Medicine, Cheonan, Korea
    Korean J Ophthalmol 19:239-42. 2005
    The authors hereby describe a case of Wernicke-Korsakoff syndrome with accompanying ocular findings that is caused by hyperernesis gravidarum.
  9. pmc Stage-dependent alterations of progenitor cell proliferation and neurogenesis in an animal model of Wernicke-Korsakoff syndrome
    Ryan P Vetreno
    Department of Psychology, Behavioral Neuroscience, State University of New York at Binghamton, Vestal, NY 13902, USA
    Brain Res 1391:132-46. 2011
    Alcohol-induced Wernicke-Korsakoff syndrome (WKS) culminates in bilateral diencephalic lesion and severe amnesia...
  10. pmc The role of cholinergic and GABAergic medial septal/diagonal band cell populations in the emergence of diencephalic amnesia
    J J Roland
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University, State University of New York, Binghamton, NY 13902, USA
    Neuroscience 160:32-41. 2009
    ..In contrast, both the PV- and CaBP-positive neurons in the MS/DB were not affected by PTD treatment. These results support an interactive role of both thalamic pathology and cholinergic cell loss in diencephalic amnesia...
  11. ncbi Age-related vulnerability to diencephalic amnesia produced by thiamine deficiency: the role of time of insult
    Shane R Pitkin
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, NY 13905, USA
    Behav Brain Res 148:93-105. 2004
    ..A rodent model of Wernicke-Korsakoff Syndrome (WKS), acute pyrithiamine-induced thiamine deficiency (PTD), produces diencephalic damage and impairments of ..
  12. pmc Increasing hippocampal acetylcholine levels enhance behavioral performance in an animal model of diencephalic amnesia
    Jessica J Roland
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University SUNY, Binghamton NY 13902, USA
    Brain Res 1234:116-27. 2008
    Pyrithiamine-induced thiamine deficiency (PTD) was used to produce a rodent model of Wernicke-Korsakoff syndrome that results in acute neurological disturbances, thalamic lesions, and learning and memory impairments...
  13. pmc Brain and behavioral pathology in an animal model of Wernicke's encephalopathy and Wernicke-Korsakoff Syndrome
    Ryan P Vetreno
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, NY 13902, USA
    Brain Res 1436:178-92. 2012
    ..changes that occur during the acute and chronic phases of thiamine deficiency and describe how rodent models of Wernicke-Korsakoff Syndrome aid in developing a more detailed picture of brain structures involved in learning and memory.
  14. ncbi The interaction of working memory performance and episodic memory formation in patients with Korsakoff's amnesia
    Bonnie van Geldorp
    Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Brain Res 1433:98-103. 2012
    ..In light of these results, the long-standing view that working memory and long-term memory are strictly dissociated may need to be revisited...
  15. ncbi Cholinergic dysfunction and amnesia in patients with Wernicke-Korsakoff syndrome: a transcranial magnetic stimulation study
    Raffaele Nardone
    Department of Neurology, Christian Doppler Clinic, Paracelsus Private Medical University, Salzburg, Austria
    J Neural Transm 117:385-91. 2010
    The specific neurochemical substrate underlying the amnesia in patients with Wernicke-Korsakoff syndrome (WKS) is still poorly defined. Memory impairment has been linked to dysfunction of neurons in the cholinergic system...
  16. ncbi Isolated prospective confabulation in Wernicke-Korsakoff syndrome: a case for reality filtering
    Armin Schnider
    Laboratory of Cognitive Neurorehabilitation, Department of Clinical Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    Neurocase 19:90-104. 2013
    ..amnesia and disorientation, accompanied by content-specific confabulation, due to an alcoholic Wernicke-Korsakoff syndrome. For months, he was deeply concerned about a single obligation that he thought he had to respond to, but ..
  17. ncbi Macrostructural abnormalities in Korsakoff syndrome compared with uncomplicated alcoholism
    A L Pitel
    INSERM, U1077, EPHE, UMR S1077, Caen, France
    Neurology 78:1330-3. 2012
    To distinguish, in patients with Korsakoff syndrome (KS), the structural brain abnormalities shared with alcoholic patients without KS (AL), from those specific to KS.
  18. pmc Neuroimaging of the Wernicke-Korsakoff syndrome
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Alcohol Alcohol 44:155-65. 2009
    ....
  19. ncbi Spatial working memory and contextual cueing in patients with Korsakoff amnesia
    Marieke Van Asselen
    Psychological Laboratory, Helmholtz Instituut, Utrecht University, The Netherlands
    J Clin Exp Neuropsychol 27:645-55. 2005
    The current study investigated the effect of Korsakoff syndrome on memory for spatial information and, in particular, the effect of contextual cueing on spatial memory retention...
  20. pmc Structural MRI volumetric analysis in patients with organic amnesia, 1: methods and comparative findings across diagnostic groups
    A Colchester
    Neuro Media Group, KIMHS, Electrical Engineering Labs, University of Kent, Canterbury, Kent, CT2 7NT, UK
    J Neurol Neurosurg Psychiatry 71:13-22. 2001
    ..Previous neuroimaging reports in patients with Korsakoff syndrome have generally found widespread or non-specific change, whereas in patients with herpes encephalitis the ..
  21. pmc Spared unconscious influences of spatial memory in diencephalic amnesia
    Albert Postma
    Experimental Psychology, Helmholtz Institute, Utrecht University, Heidelberglaan 2, 3584 CS, Utrecht, The Netherlands
    Exp Brain Res 190:125-33. 2008
    ..The presented results suggest that conscious and unconscious influences of spatial memory can be clearly dissociated in Korsakoff's syndrome...
  22. ncbi A cluster of polyneuropathy and Wernicke-Korsakoff syndrome in a bariatric unit
    Luiz Claudio Lopes Chaves
    Obesity Surgery Group, Hospital Ofir Loyola, Belem, Para, Brazil
    Obes Surg 12:328-34. 2002
    Wernicke-Korsakoff syndrome and peripheral neuropathy are very uncommon in bariatric surgical practice. The literature indicates that these complications tend to strike patients receiving unbalanced diets or undergoing rapid weight-loss.
  23. ncbi Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre
    Clive Harper
    Department of Neuropathology, Institute for Clinical Neurosciences, Central Sydney Area Health Service, Camperdown, NSW, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 27:951-61. 2003
    ..The most significant of these is the alcohol-related vitamin deficient state, the Wernicke-Korsakoff syndrome (WKS), which is caused by thiamin deficiency but is seen most commonly in alcoholics...
  24. ncbi Procedural memory in Korsakoff's disease under different movement feedback conditions
    Stephan P Swinnen
    Laboratory of Motor Control, Department of Kinesiology, Group Biomedical Sciences, K U Leuven, Tervuurse Vest 101, 3001 Leuven, Belgium
    Behav Brain Res 159:127-33. 2005
    ..This prompts for a reevaluation of current notions about procedural memory capacity in Korsakoff patients...
  25. ncbi [Particular aspects of bioelectric brain activity in post-traumatic Korsakoff syndrome]
    E R Obraztsova
    Zh Nevrol Psikhiatr Im S S Korsakova 103:59-65. 2003
    ..In the context of clinical data, this EEG phenomenon may be related to inhibited state of corresponding cortical areas...
  26. ncbi A placebo-controlled study of memantine (Ebixa) in dementia of Wernicke-Korsakoff syndrome
    Avdo Rustembegovic
    Anton Proksch Institute, Department of Alcohol and Drug Dependence, Vienna, Austria
    Med Arh 57:149-50. 2003
    ..and tolerability of the memantine, and NMDA antagonist, in the treatment of dementia in Wernicke-Korsakoff syndrome. In this study, for the first time in dementia of Wernicke-Korsakoff syndrome, the response to memantine was ..
  27. ncbi Spatial and non-spatial contextual working memory in patients with diencephalic or hippocampal dysfunction
    Carinne Piekema
    Helmholtz Institute, Utrecht University, The Netherlands
    Brain Res 1172:103-9. 2007
    ..However, we did not find a disproportionate inability in maintaining spatial or non-spatial associations within working memory as previously demonstrated in long-term memory...
  28. ncbi Memory for object locations in Korsakoff's amnesia
    R P Kessels
    Psychological Laboratory, Utrecht University, The Netherlands
    Cortex 36:47-57. 2000
    ..No evidence for selective impairments could be observed. These impairments can be linked to damage of diencephalic regions and perhaps the parietal cortex...
  29. ncbi FDG-PET findings in the Wernicke-Korsakoff syndrome
    Laurence J Reed
    University Dept of Psychiatry and Psychology, St Thomas s Hospital, Kings College, London, UK
    Cortex 39:1027-45. 2003
    ..Twelve patients suffering amnesia arising from the Korsakoff syndrome were compared with 10 control subjects without alcohol-related disability...
  30. ncbi Acetylcholinesterase inhibitors for the treatment of Wernicke-Korsakoff syndrome--three further cases show response to donepezil
    Murray Cochrane
    Parkhead Hospital, 81 Salamanca Street, Glasgow, G31 5ES, UK
    Alcohol Alcohol 40:151-4. 2005
    Three patients diagnosed with Wernicke-Korsakoff syndrome were treated with the acetylcholinesterase inhibitor, donepezil, for periods of 6 to 8 months...
  31. ncbi Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS)
    Irene Guerrini
    Molecular Psychiatry Laboratory, Windeyer Institute of Medical Sciences, Department of Mental Health Sciences, Royal Free and University College London Medical School, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 137:17-9. 2005
  32. ncbi Individual susceptibility to Wernicke-Korsakoff syndrome and alcoholism-induced cognitive deficit: impaired thiamine utilization found in alcoholics and alcohol abusers
    Laura C Heap
    Department of Clinical Biochemistry, Kings College School of Medicine and Dentistry, London, UK
    Psychiatr Genet 12:217-24. 2002
    ..We conclude that thiamine deficiency was commonly present in the alcoholic patients, and that a subgroup of patients may be predisposed to more severe brain damage as a consequence of abnormalities in the transketolase protein...
  33. ncbi Acute Korsakoff syndrome following mammillothalamic tract infarction
    Yuichiro Yoneoka
    Department of Neurosurgery, Yamagata Prefecture Central Hospital, Yamagata, Japan
    AJNR Am J Neuroradiol 25:964-8. 2004
    There are limited case reports of structural lesions causing Korsakoff syndrome. This report describes acute Korsakoff syndrome following localized, bilateral infarction of the mammillothalamic tracts (MTTs)...
  34. ncbi Intact memory for implicit contextual information in Korsakoff's amnesia
    Erik Oudman
    Helmholtz Institute, Experimental Psychology, Utrecht University, Utrecht, The Netherlands
    Neuropsychologia 49:2848-55. 2011
    ..The implicit learning effect was not related to the spatial working memory scores. Together these results clearly suggest that implicit and explicit spatial memory have a different neurocognitive basis...
  35. ncbi Correlation between phosphorylation level of a hippocampal 86kDa protein and extinction of a behaviour in a model of Wernicke-Korsakoff syndrome
    Rita G W Pires
    Departamento de Bioquímica Imunologia, Laboratório de Neurociência Comportamental e Molecular LaNeC, Universidade Federal de Minas Gerais, Belo Horizonte 31270 010, Brazil
    Behav Brain Res 180:102-6. 2007
    ..These data add to and extend previous findings by our laboratory implicating the involvement of hippocampal neurotransmission components in extinction of a behaviour which involves learning of environmental spatial cues...
  36. pmc Not all repetition is alike: different benefits of repetition in amnesia and normal memory
    Mieke Verfaellie
    Memory Disorders Research Center, Boston VA Healthcare System and Boston University School of Medicine, Boston, MA 02130, USA
    J Int Neuropsychol Soc 14:365-72. 2008
    ..We conclude that the repetition of information, and especially repetition in varied contexts, enhances recollection in individuals with intact memory, but exclusively affects familiarity in patients with severe amnesia...
  37. ncbi Word frequency and word stem completion in Korsakoff patients
    H R Phaf
    Psychonomics Department, University of Amsterdam, The Netherlands
    J Clin Exp Neuropsychol 22:817-29. 2000
    ....
  38. ncbi Memory and the Korsakoff syndrome: not remembering what is remembered
    Gery d'Ydewalle
    Department of Psychology, University of Leuven, B 3000 Leuven, Belgium
    Neuropsychologia 45:905-20. 2007
    ....
  39. ncbi Route learning in amnesia: a comparison of trial-and-error and errorless learning in patients with the Korsakoff syndrome
    Roy P C Kessels
    NICI, Neuropsychology and Rehabilitation, Radboud University Nijmegen and Department of Medical Psychology, Radboud University Nijmegen Medical Centre, The Netherlands
    Clin Rehabil 21:905-11. 2007
    ..To examine the errorless learning approach using a procedural memory task (i.e. learning of actual routes) in patients with amnesia, as compared to trial-and-error learning...
  40. ncbi Spatial and temporal order memory in Korsakoff patients
    Albert Postma
    Psychological Laboratory, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands
    J Int Neuropsychol Soc 12:327-36. 2006
    ..Moreover, their lower recall of both features at the same time suggests that Korsakoff patients are impaired in binding different contextual attributes together in memory...
  41. ncbi Frontal lobe dysfunctions in Korsakoff's syndrome and chronic alcoholism: continuity or discontinuity?
    B Brokate
    Department of Psychiatry and Psychotherapy, Municipal Hospital of Bremen, Germany
    Neuropsychology 17:420-8. 2003
    ..Second, the decline in the ability to alternate between different responses argues for a restricted neurotoxic effect of alcohol on some frontal lobe areas...
  42. ncbi [Trends in study of Wernicke-Korsakoff syndrome]
    Kenji Kosaka
    Seishin Shinkeigaku Zasshi 109:509-15. 2007
  43. ncbi Persistence of disturbed thalamic glucose metabolism in a case of Wernicke-Korsakoff syndrome
    Andreas Fellgiebel
    Department of Psychiatry, University Hospital of Mainz, Untere Zahlbacher Str 8, Mainz, Germany
    Psychiatry Res 124:105-12. 2003
    ..After admission, an amnestic syndrome with confabulation was also observed and diagnosis of Wernicke-Korsakoff syndrome was made...
  44. pmc Blunted hippocampal, but not striatal, acetylcholine efflux parallels learning impairment in diencephalic-lesioned rats
    Jessica J Roland
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University SUNY, Binghamton, NY 13902, USA
    Neurobiol Learn Mem 87:123-32. 2007
    ..The results support selective diencephalic-hippocampal dysfunction in the PTD model. This diencephalic-hippocampal interaction appears to be critical for successful episodic and spatial learning/memory...
  45. ncbi Effect of kami-untan-to on the impairment of learning and memory induced by thiamine-deficient feeding in mice
    O Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Neuroscience 125:233-41. 2004
    ..These results suggest that the effect of KUT on the impairment of memory-related behavior induced by TD feeding may be closely related to the activation of cholinergic neurons in the hippocampus...
  46. pmc Alcohol and the nervous system
    C McIntosh
    Royal Edinburgh Hospital, Morningside Terrace, Edinburgh EH10 5HF, UK
    J Neurol Neurosurg Psychiatry 75:iii16-21. 2004
  47. ncbi The natural history and pathophysiology of Wernicke's Encephalopathy and Korsakoff's Psychosis
    Allan D Thomson
    Molecular Psychiatry Laboratory, Windeyer Institute of Medical Sciences, Department of Mental Health Sciences, Royal Free and University College, London Medical School, London UK
    Alcohol Alcohol 41:151-8. 2006
    ..It is hoped that this will highlight the need for clinicians to treat alcohol-dependent patients prophylactically with parenteral thiamine and thus prevent the development of Korsakoff's Psychosis (KP)...
  48. ncbi Development and resolution of brain lesions caused by pyrithiamine- and dietary-induced thiamine deficiency and alcohol exposure in the alcohol-preferring rat: a longitudinal magnetic resonance imaging and spectroscopy study
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Neuropsychopharmacology 32:1159-77. 2007
    ....
  49. ncbi Enhanced head-twitch response to 5-HT-related agonists in thiamine-deficient mice
    O Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
    J Neural Transm 114:1003-10. 2007
    ..systems in neuro-psychiatric disorders such as schizophrenia and depression, their role in Wernicke-Korsakoff syndrome (WKS) remains unclear...
  50. pmc The anatomy of amnesia: neurohistological analysis of three new cases
    Jeffrey J Gold
    Veterans Affairs Medical Center, San Diego, California 92161, USA
    Learn Mem 13:699-710. 2006
    ..These findings illuminate several issues regarding the relation between diencephalic and medial temporal lobe amnesia, the status of recognition memory in amnesia, and the neuroanatomy of memory...
  51. ncbi The current state of S. S. Korsakov's concept of alcoholic polyneuritic psychosis
    Yu P Sivolap
    Department of Psychiatry and Medical Psychology, I M Sechenov Moscow Medical Academy, Russia
    Neurosci Behav Physiol 35:977-82. 2005
  52. ncbi Nerve growth factor in serum is a marker of the stage of alcohol disease
    Maria C Jockers-Scherübl
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Neurosci Lett 419:78-82. 2007
    ..In accordance with this hypothesis, NGF values are "normal" in patients with persistent alcohol-related cognitive decline...
  53. pmc Reversible acute axonal polyneuropathy associated with Wernicke-Korsakoff syndrome: impaired physiological nerve conduction due to thiamine deficiency?
    S Ishibashi
    Department of Neurology and Neurological Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Neurol Neurosurg Psychiatry 74:674-6. 2003
    ..CMAPs, SNAPs, and SSRs also increased considerably. We suggest that this is a new type of peripheral nerve impairment: physiological conduction failure with minimal conduction delay due to thiamine deficiency...
  54. ncbi The alcohol withdrawal syndrome
    A McKeon
    Department of Neurology and Clinical Neurosciences, Beaumont Hospital, Dublin, and Royal College of Surgeons in Ireland, Dublin, Ireland
    J Neurol Neurosurg Psychiatry 79:854-62. 2008
    ..Many patients with AWS have multiple management issues (withdrawal symptoms, delirium tremens, the Wernicke-Korsakoff syndrome, seizures, depression, polysubstance abuse, electrolyte disturbances and liver disease), which requires a ..
  55. ncbi Temporal order memory in patients with Korsakoff's syndrome and medial temporal amnesia
    John Joseph Downes
    Department of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 72A, UK
    Neuropsychologia 40:853-61. 2002
    ....
  56. ncbi [Thiamine deficiency caused by malnutrition: a rare cause?]
    P G Jong Baw
    Parnassia Bavo Groep Den Haag
    Tijdschr Psychiatr 50:611-5. 2008
    ..If in doubt, always opt for thiamine suppletion...
  57. doi Alcohol use, thiamine deficiency, and cognitive impairment
    Frances R Frankenburg
    JAMA 299:2854; author reply 2854-5. 2008
  58. ncbi Perceptual learning in amnesia
    Manfred Fahle
    Department of Human Neurobiology, University of Bremen, Argonnenstr 3, D 28211 Bremen, Germany
    Neuropsychologia 40:1167-72. 2002
    ..This result corroborates the notion of a relatively 'front end' location of at least some forms of perceptual learning...
  59. ncbi Voxel-based mapping of brain hypometabolism in permanent amnesia with PET
    A M Aupée
    INSERM U320, Cyceron and Department of Neurology, University of Caen, France
    Neuroimage 13:1164-73. 2001
    ..The use of a voxel-based method allowed us to map a common network of synaptic dysfunction in a neuropsychological syndrome regardless of etiology. Our results indicate that this should be a powerful method in functional neuropsychology...
  60. ncbi Is implicit learning spared in amnesia? Rule abstraction and item familiarity in artificial grammar learning
    Shelley Channon
    Subdepartment of Clinical Health Psychology, University College London, Gower Street, UK
    Neuropsychologia 40:2185-97. 2002
    ..However, this sensitivity to bigram familiarity was significantly reduced in the amnesic compared to the control group. The results challenge the claim that implicit learning is intact in amnesia...
  61. ncbi The National Adult Reading Test as a measure of premorbid intelligence: a comparison with estimates derived from demographic variables
    Peter Bright
    University Department of Psychiatry and Psychology, King s College, London, UK
    J Int Neuropsychol Soc 8:847-54. 2002
    ..The data offer reassurance regarding the continued use of NART as a valid estimate of premorbid intelligence in a number of conditions...
  62. ncbi [Wernicke-Korsakoff syndrome: malignant tumour as triggering factor]
    J Guisado
    , Facultad de Medicina, Universidad de Extremadura, Badajoz
    Actas Esp Psiquiatr 29:279-81. 2001
    ..alcoholism and malignant tumour are three predisponing risk factors for the development of Wernicke-Korsakoff syndrome. We described the clinical case of a patient with history of alcoholism that developed Wernicke-Korsakoff ..
  63. ncbi [Wernicke encephalopathy after subtotal gastrectomy for morbid obesity]
    C Gabaudan
    Service d Imagerie Medicale, hôpital Laveran, boulevard Laveran, 13013 Marseille, France
    Rev Neurol (Paris) 164:463-7. 2008
    ..The interest of nutritional supervision in the first weeks and preventive thiamine supplementation in case of repeated vomiting are of particular importance in these risky situations...
  64. ncbi The effect of retrieval instructions on false recognition: exploring the nature of the gist memory impairment in amnesia
    Mieke Verfaellie
    Memory Disorders Research Center 151A, Boston VA Healthcare System, 150 S Huntington Avenue, Boston, MA 02130, USA
    Neuropsychologia 40:2360-8. 2002
    ..Rather, it suggests that amnesic patients are impaired in their ability to encode, store, or maintain strong gist information...
  65. ncbi Confabulation behavior and false memories in Korsakoff's syndrome: role of source memory and executive functioning
    Roy P C Kessels
    Nijmegen Institute for Cognition and Information, Radboud University Nijmegen, The Netherlands
    Psychiatry Clin Neurosci 62:220-5. 2008
    ..Provoked confabulations may be related to intrusions on memory tests, whereas spontaneous confabulations may be due to executive dysfunction or a source memory deficit...
  66. ncbi Wernicke-Korsakoff syndrome and galantamine
    B Kirk Phillips
    Psychosomatics 45:366-8. 2004
  67. ncbi Decision-making deficits of korsakoff patients in a new gambling task with explicit rules: associations with executive functions
    Matthias Brand
    Department of Physiological Psychology, University of Bielefeld, Bielefeld, Germany
    Neuropsychology 19:267-77. 2005
    ..Results show that Korsakoff patients are strongly impaired in this explicit decision-making task and that these disturbances are correlated with specific executive functions...
  68. ncbi [Neuropsychology of Korsakoff's syndrome]
    J Cabanyes
    Departamento de Neurologia, Clinica Salvia, Madrid
    Neurologia 19:183-92. 2004
    ..The aim of this paper is to review the most important neuropsychological features of Korsakoff's syndrome and to discuss the hypotheses on it...
  69. ncbi [Neuropsychological deficits in alcoholics: some implications for road safety]
    M J Garrido
    Departamento de Psicología Básica II, Universidad Complutense, Madrid, Espana
    Rev Neurol 38:277-83. 2004
    ..We also will analyse the involvement of these deficit in a complex task as driving...
  70. ncbi Alcohol, cognitive impairment and the hard to discharge acute hospital inpatients
    A Popoola
    Professorial Psychiatric Unit, Cork University Hospital, Cork, Ireland
    Ir J Med Sci 177:141-5. 2008
    ..To examine the role of alcohol and alcohol-related cognitive impairment in the clinical presentation of adults in-patients less than 65 years who are 'hard to discharge' in a general hospital...
  71. ncbi No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome
    S Matsushita
    Department of Clinical Research, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa, Japan
    Neurobiol Aging 22:569-74. 2001
    ..Also characterized by reduced KGDHC activity is another neuropsychiatric disease, Wernicke-Korsakoff syndrome (WKS), which results from thiamine deficiency...
  72. ncbi Frontal dysfunction and frontal cortical synapse loss in alcoholism--the main cause of alcohol dementia?
    A Brun
    Department of Forensic Medicine, Lund, Sweden
    Dement Geriatr Cogn Disord 12:289-94. 2001
    ..The cortical changes are closely similar to those found in frontotemporal dementia, and seem to be a plausible main cause of the alcoholic frontal symptomatology and alcoholic dementia...
  73. ncbi Episodic and working memory deficits in alcoholic Korsakoff patients: the continuity theory revisited
    Anne Lise Pitel
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Alcohol Clin Exp Res 32:1229-41. 2008
    ....
  74. ncbi The cost of living in purgatory's shadow
    Michael S Vaphiades
    The Departments of Ophthalmology, Neurology and Neurosurgery, University of Alabama Birmingham, USA
    J Ark Med Soc 101:146-7. 2004
    A 40-year-old alcoholic man developed Wernicke-Korsakoff syndrome. His examination showed ophthalmoplegia, ataxia and memory difficulties...
  75. ncbi Bright red nuclei
    Laurence J Kinsella
    Neurology 63:1543; author reply 1543. 2004
  76. ncbi Dramatic recovery from prolonged Wernicke-Korsakoff disease
    Antonio Carota
    Service de Rééducation, Hopital Cantonal Universitaire, Geneve, Suisse
    Eur Neurol 53:45-6. 2005
  77. ncbi Thiamine pyrophosphate-requiring enzymes are altered during pyrithiamine-induced thiamine deficiency in cultured human lymphoblasts
    S R Pekovich
    Department of Molecular Biology, Vanderbilt University, Nashville, TN 37325, USA
    J Nutr 126:1791-8. 1996
    The most common of the severe complications of thiamine deficiency are beriberi and Wernicke-Korsakoff syndrome. To help clarify the biochemical basis for these disorders, a cell culture system has been established in which pyrithiamine, ..
  78. ncbi Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus callosum ultrastructure
    Xiaohua He
    Department of Pathology D06, University of Sydney, Sydney, NSW 2006, Australia
    Neuropsychopharmacology 32:2207-16. 2007
    ..and thiamine deficiency in causing brain damage remain controversial in alcoholics without the Wernicke-Korsakoff syndrome. Experimental control over alcohol consumption and diet are impossible in humans but can be accomplished in ..
  79. ncbi Optimum nutrition: thiamin, biotin and pantothenate
    D A Bender
    Department of Biochemistry and Molecular Biology, University College London, UK
    Proc Nutr Soc 58:427-33. 1999
    ..2.1.1) is the thiamin-dependent step. It has been suggested that the Wernicke-Korsakoff syndrome is associated with a genetic variant of transketolase which requires a higher than normal concentration of ..
  80. pmc Impaired, spared, and enhanced ACh efflux across the hippocampus and striatum in diencephalic amnesia is dependent on task demands
    Ryan P Vetreno
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University, State University of New York, Binghamton, NY 13902, USA
    Neurobiol Learn Mem 90:237-44. 2008
    ..brain lesions and impairments similar in nature and distribution to those observed in humans with Wernicke-Korsakoff syndrome (WKS)...
  81. pmc Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans
    Liesbeth de Jong
    Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
    Genetics 168:845-54. 2004
    ..in the diet of animals, and thiamine deficiency leads to diseases such as beri-beri and the Wernicke-Korsakoff syndrome. Dietary thiamine (vitamin B1) consists mainly of thiamine pyrophosphate (TPP), which is transformed into ..
  82. ncbi The psychiatric management of patients with alcohol dependence
    Jonathan I Ritvo
    Charles Park, MD Department of Psychiatry, University of Hawaii, 1356 Lusitana Street, UH Tower, Fourth Floor, Honolulu, HI 96813, USA
    Curr Treat Options Neurol 9:381-92. 2007
    ..administration of intravenous fluids to prevent the development of Wernicke's encephalopathy and Wernicke-Korsakoff syndrome. In combination with psychosocial treatment, disulfiram, naltrexone, and acamprosate can reduce the ..
  83. ncbi [Beriberi after bariatric surgery: not an unusual complication. Report of two cases and literature review]
    Lilian F A Alves
    Servico de Endocrinologia, Hospital Felicio Rocho, Rua Monte Alegre 851, 30240 230 Belo Horizonte, MG
    Arq Bras Endocrinol Metabol 50:564-8. 2006
    ..Two patients with the clinic of peripheral neuropathy and Wernicke-Korsakoff syndrome will be reported...
  84. ncbi Molecular genetics of alcohol-related brain damage
    Irene Guerrini
    Bexley Substance Misuse Service, South London and Mausdley NHS Trust, London, UK
    Alcohol Alcohol 44:166-70. 2009
    ..The aim of this paper is to review the most recent knowledge on the genetic susceptibility to the development of alcohol-related Wernicke-Korsakoff syndrome (WKS).
  85. ncbi B Vitamin deficiency and neuropsychiatric syndromes in alcohol misuse
    C C Cook
    Kent Institute of Medicine and Health Sciences, University of Kent at Canterbury, UK
    Alcohol Alcohol 33:317-36. 1998
    ..In particular, the Wernicke Korsakoff syndrome (WKS)...
  86. pmc Blocking GABA-A receptors in the medial septum enhances hippocampal acetylcholine release and behavior in a rat model of diencephalic amnesia
    Jessica J Roland
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University State University of New York, NY, USA
    Pharmacol Biochem Behav 92:480-7. 2009
    Wernicke-Korsakoff syndrome (WKS), a form of diencephalic amnesia caused by thiamine deficiency, results in severe anterograde memory loss...
  87. pmc Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells
    Marjorie Gangolf
    GIGA Neurosciences, University of Liege, Liege, Belgium
    PLoS ONE 5:e13616. 2010
    ..Diseases linked to thiamine deficiency (polyneuritis, Wernicke-Korsakoff syndrome) remain frequent among alcohol abusers and other risk populations...
  88. ncbi Persistence of habituation deficits after neurological recovery from severe thiamine deprivation
    K Le Roch
    Departement de Psychophysiologie, C N R S, Gif sur Yvette, France
    Behav Brain Res 26:37-46. 1987
    ..These symptoms are reminiscent of the clinical Wernicke-Korsakoff syndrome. Injection of thiamine dramatically reversed these symptoms within one or two hours as seen in Wernicke ..
  89. ncbi Neurological complications of prolonged hunger strike
    M Basoglu
    Neurology Department, Ataturk Training and Research Hospital, Izmir, Turkey
    Eur J Neurol 13:1089-97. 2006
    ..for 60-294 days (mean 156) during the hunger strike, and had neurological findings consistent with Wernicke-Korsakoff syndrome. All 41 patients exhibited altered consciousness which lasted from 3 to 31 days...
  90. ncbi Confabulations in alcoholic Korsakoff patients
    Sabine Borsutzky
    Physiological Psychology, University of Bielefeld, Bielefeld, Germany
    Neuropsychologia 46:3133-43. 2008
    ..Although confabulations are described anecdotally in patients with alcoholic Korsakoff syndrome (KS), there are few systematic investigations of the presence and nature of these types of false memories in ..
  91. ncbi Anthocyanins: are they beneficial in treating ethanol neurotoxicity?
    Gang Chen
    Department of Internal Medicine, College of Medicine, University of Kentucky, 124C Combs Research Building, 800 Rose Street, Lexington, KY, 40536, USA
    Neurotox Res 17:91-101. 2010
    ..Excessive alcohol consumption is associated with Wernicke-Korsakoff syndrome (WKS) and neurodegeneration in the adult brain...
  92. ncbi Wernicke's encephalopathy in a malnourished surgical patient: clinical features and magnetic resonance imaging
    M Nolli
    Anaesthesia Unit, Department of Emergency and Critical Area, General Hospital La Spezia, Italy
    Acta Anaesthesiol Scand 49:1566-70. 2005
    ..This progressed to typical Wernicke-Korsakoff syndrome with ataxia and memory and cognitive defects...
  93. ncbi Neuromuscular consequences of prolonged hunger strike: an electrophysiological study
    A E Oge
    Department of Neurology, Istanbul University, Istanbul Faculty of Medicine, Capa 34390, Istanbul, Turkey
    Clin Neurophysiol 111:2064-70. 2000
    ..The purpose of this study was to determine the electrophysiological consequences of neuromuscular and central nervous system involvement in a group of patients presented with the neurological complications of a long-term hunger strike (HS)...
  94. ncbi The glutamatergic basis of human alcoholism
    G Tsai
    Laboratory of Molecular and Developmental Neuroscience, Massachusetts General Hospital
    Am J Psychiatry 152:332-40. 1995
    ..Neurobiological effects of alcoholism, such as intoxication, withdrawal seizures, delirium tremens, Wernicke-Korsakoff syndrome, and fetal alcohol syndrome, can be understood as a spectrum of consequences of ethanol's effect on the ..
  95. ncbi Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase
    M Abedinia
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    Biochem Biophys Res Commun 183:1159-66. 1992
    ..in the pentose-phosphate pathway which has been implicated in the latent human genetic disease, Wernicke-Korsakoff syndrome. Here we report the cloning and partial characterisation of the coding sequences encoding human ..
  96. pmc Lithium-mediated protection against ethanol neurotoxicity
    Jia Luo
    Department of Internal Medicine, University of Kentucky College of Medicine Lexington, KY, USA
    Front Neurosci 4:41. 2010
    ..Excessive alcohol consumption is also associated with Wernicke-Korsakoff syndrome and neurodegeneration in the adult brain...
  97. ncbi Persistent altered mentation due to ethanol
    M Victor
    Department of Medicine Neurology, Dartmouth Medical School, Hanover, New Hampshire
    Neurol Clin 11:639-61. 1993
    ..The dementing diseases of Wernicke-Korsakoff syndrome, pellagra, the nonfamilial form of hepatocerebral degeneration, Marchiafava-Bignami disease, and alcoholic ..
  98. pmc Anorexia nervosa and Wernicke-Korsakoff syndrome: a case report
    Laura Saad
    Department of Psychiatry, Faculty of Medical Sciences, University of Campinas UNICAMP, PO Box 6111, Campinas, SP Brazil, ZIP code 13081 970
    J Med Case Reports 4:217. 2010
    ..Wernicke's encephalopathy has traditionally been associated with alcoholism but, in recent years, there has been an increase in the number of clinical settings in which the disorder is observed...
  99. ncbi The neurotoxicity of alcohol
    Clive Harper
    Department of Pathology, Blackburn Building, D06, University of Sydney, NSW 2006, Australia
    Hum Exp Toxicol 26:251-7. 2007
    ..and other brain regions damaged in patients who have additional vitamin B1 (thiamine) deficiency (Wernicke-Korsakoff syndrome)...
  100. ncbi Memory for subject performed tasks in patients with Korsakoff syndrome
    M Mimura
    Department of Neuropsychiatry, Tokyo Dental College Ichikawa General Hospital
    Cortex 34:297-303. 1998
    ..Domains preserved in this amnesic syndrome may account for the benefit seen when using SPTs in Korsakoff patients. The therapeutic utilization of action events for memory rehabilitation is discussed...
  101. ncbi Cognitive performance of detoxified alcoholic Korsakoff syndrome patients remains stable over two years
    Esther Fujiwara
    Physiological Psychology, University of Bielefeld, Bielefeld, Germany
    J Clin Exp Neuropsychol 30:576-87. 2008
    ..However, little is known about the time course of cognitive functions in patients with chronic alcoholic Korsakoff syndrome (KS)...

Research Grants13

  1. Hippocampus/Pituitary Ratio: an AD Brain Injury Marker?
    Thomas Beresford; Fiscal Year: 2005
    ..Others found such neuro-endocrine abnormalities more frequently among Wernicke-Korsakoff Syndrome cases, suggesting a possible relation to brain injury...
  2. IMPAIRED AND PRESERVED MEMORY PROCESSES IN AMNESIA
    Mieke Verfaellie; Fiscal Year: 2007
    ..abstract_text> ..
  3. BRAIN-INJURY MEMORY DISORDERS RESEARCH CENTER
    Mieke Verfaellie; Fiscal Year: 2003
    ..The interactions between the investigators from the five investigative components supported by the core programs constitute the fabric of our Center. ..
  4. Brain Tissue Resource Centre for Alcohol Research
    Clive Harper; Fiscal Year: 2007
    ..Funding is sought to help further develop this important resource for international researchers with an interest in alcohol-related brain damage. ..
  5. The Role of Acetylcholine Dysfunction in Diencephalic Amnesia
    Lisa M Savage; Fiscal Year: 2010
    ..Such experiments are critical to understanding the role of acetylcholine dysfunction in amnesia and thus the development of pharmacotherapeutics. ..
  6. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2008
    ..abstract_text> ..
  7. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    EDITH VIONI SULLIVAN; Fiscal Year: 2010
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  8. Alcoholism risk and protective factors in Trinidad
    Cindy Ehlers; Fiscal Year: 2006
    ..Study findings can be compared to similar studies being conducted in the US. We believe these studies will allow for the identification of risk and protective factors for alcoholism in these islands. [unreadable] [unreadable]..
  9. Neurobehavioral Consequences of Adolescent Alcohol
    Cindy Ehlers; Fiscal Year: 2008
    ..AIM 3: To investigate the neurochemical substrates underlying the lasting neurobehavioral consequences of adolescent ethanol exposure, with a focus on NMDA systems ..
  10. ADOLESCENT MARIJUANA USE IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2008
    ..abstract_text> ..
  11. RISK FACTORS FOR ALCOHOLISM IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2006
    ..The identification of such variables may potentially be useful in the development of specific prevention and treatment programs for this population as well as other Native American tribes. ..
  12. REGULATION OF DEVELOPMENT BY PHOSPHORELAY SIGNALING
    CHARLES SINGLETON; Fiscal Year: 2002
    ..Finally genetic screens for suppressers or synthetic phenotypes will identify new and perhaps novel components of the regulatory pathway, including upstream inputs, phosphorelay regulators, and downstream effectors. ..