korsakoff syndrome

Summary

Summary: An acquired cognitive disorder characterized by inattentiveness and the inability to form short term memories. This disorder is frequently associated with chronic ALCOHOLISM; but it may also result from dietary deficiencies; CRANIOCEREBRAL TRAUMA; NEOPLASMS; CEREBROVASCULAR DISORDERS; ENCEPHALITIS; EPILEPSY; and other conditions. (Adams et al., Principles of Neurology, 6th ed, p1139)

Top Publications

  1. doi The Korsakoff syndrome: clinical aspects, psychology and treatment
    Michael D Kopelman
    King s College London, Institute of Psychiatry, London, UK
    Alcohol Alcohol 44:148-54. 2009
  2. ncbi Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management
    GianPietro Sechi
    Institute of Clinical Neurology, University of Sassari, Italy
    Lancet Neurol 6:442-55. 2007
  3. doi The interaction of working memory performance and episodic memory formation in patients with Korsakoff's amnesia
    Bonnie van Geldorp
    Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Brain Res 1433:98-103. 2012
  4. ncbi Memory and the Korsakoff syndrome: not remembering what is remembered
    Gery d'Ydewalle
    Department of Psychology, University of Leuven, B 3000 Leuven, Belgium
    Neuropsychologia 45:905-20. 2007
  5. pmc Not all repetition is alike: different benefits of repetition in amnesia and normal memory
    Mieke Verfaellie
    Memory Disorders Research Center, Boston VA Healthcare System and Boston University School of Medicine, Boston, MA 02130, USA
    J Int Neuropsychol Soc 14:365-72. 2008
  6. ncbi Route learning in amnesia: a comparison of trial-and-error and errorless learning in patients with the Korsakoff syndrome
    Roy P C Kessels
    NICI, Neuropsychology and Rehabilitation, Radboud University Nijmegen and Department of Medical Psychology, Radboud University Nijmegen Medical Centre, The Netherlands
    Clin Rehabil 21:905-11. 2007
  7. ncbi Individual susceptibility to Wernicke-Korsakoff syndrome and alcoholism-induced cognitive deficit: impaired thiamine utilization found in alcoholics and alcohol abusers
    Laura C Heap
    Department of Clinical Biochemistry, Kings College School of Medicine and Dentistry, London, UK
    Psychiatr Genet 12:217-24. 2002
  8. ncbi Frontal lobe dysfunctions in Korsakoff's syndrome and chronic alcoholism: continuity or discontinuity?
    B Brokate
    Department of Psychiatry and Psychotherapy, Municipal Hospital of Bremen, Germany
    Neuropsychology 17:420-8. 2003
  9. ncbi Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS)
    Irene Guerrini
    Molecular Psychiatry Laboratory, Windeyer Institute of Medical Sciences, Department of Mental Health Sciences, Royal Free and University College London Medical School, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 137:17-9. 2005
  10. ncbi Acute Korsakoff syndrome following mammillothalamic tract infarction
    Yuichiro Yoneoka
    Department of Neurosurgery, Yamagata Prefecture Central Hospital, Yamagata, Japan
    AJNR Am J Neuroradiol 25:964-8. 2004

Research Grants

  1. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2007
  2. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2010
  3. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2009
  4. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2010
  5. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2009
  6. Hippocampus/Pituitary Ratio: an AD Brain Injury Marker?
    Thomas Beresford; Fiscal Year: 2005
  7. MEMORY AS AFFECTED BY AGING, DISEASE AND ECT
    Larry Squire; Fiscal Year: 1980
  8. Effects of Repetition on Learning and Memory in Amnesia
    Mieke Verfaellie; Fiscal Year: 2007
  9. BRAIN-INJURY MEMORY DISORDERS RESEARCH CENTER
    Mieke Verfaellie; Fiscal Year: 2003
  10. BRAIN TISSUE RESOURCE CENTER FOR ALCOHOL RESEARCH
    Clive Harper; Fiscal Year: 2002

Detail Information

Publications169 found, 100 shown here

  1. doi The Korsakoff syndrome: clinical aspects, psychology and treatment
    Michael D Kopelman
    King s College London, Institute of Psychiatry, London, UK
    Alcohol Alcohol 44:148-54. 2009
    The Korsakoff syndrome is a preventable memory disorder that usually emerges (although not always) in the aftermath of an episode of Wernicke's encephalopathy...
  2. ncbi Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management
    GianPietro Sechi
    Institute of Clinical Neurology, University of Sassari, Italy
    Lancet Neurol 6:442-55. 2007
    ..A systematic approach helps to ensure that patients receive a prompt diagnosis and adequate treatment...
  3. doi The interaction of working memory performance and episodic memory formation in patients with Korsakoff's amnesia
    Bonnie van Geldorp
    Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Brain Res 1433:98-103. 2012
    ..In light of these results, the long-standing view that working memory and long-term memory are strictly dissociated may need to be revisited...
  4. ncbi Memory and the Korsakoff syndrome: not remembering what is remembered
    Gery d'Ydewalle
    Department of Psychology, University of Leuven, B 3000 Leuven, Belgium
    Neuropsychologia 45:905-20. 2007
    ....
  5. pmc Not all repetition is alike: different benefits of repetition in amnesia and normal memory
    Mieke Verfaellie
    Memory Disorders Research Center, Boston VA Healthcare System and Boston University School of Medicine, Boston, MA 02130, USA
    J Int Neuropsychol Soc 14:365-72. 2008
    ..We conclude that the repetition of information, and especially repetition in varied contexts, enhances recollection in individuals with intact memory, but exclusively affects familiarity in patients with severe amnesia...
  6. ncbi Route learning in amnesia: a comparison of trial-and-error and errorless learning in patients with the Korsakoff syndrome
    Roy P C Kessels
    NICI, Neuropsychology and Rehabilitation, Radboud University Nijmegen and Department of Medical Psychology, Radboud University Nijmegen Medical Centre, The Netherlands
    Clin Rehabil 21:905-11. 2007
    ..To examine the errorless learning approach using a procedural memory task (i.e. learning of actual routes) in patients with amnesia, as compared to trial-and-error learning...
  7. ncbi Individual susceptibility to Wernicke-Korsakoff syndrome and alcoholism-induced cognitive deficit: impaired thiamine utilization found in alcoholics and alcohol abusers
    Laura C Heap
    Department of Clinical Biochemistry, Kings College School of Medicine and Dentistry, London, UK
    Psychiatr Genet 12:217-24. 2002
    ..We conclude that thiamine deficiency was commonly present in the alcoholic patients, and that a subgroup of patients may be predisposed to more severe brain damage as a consequence of abnormalities in the transketolase protein...
  8. ncbi Frontal lobe dysfunctions in Korsakoff's syndrome and chronic alcoholism: continuity or discontinuity?
    B Brokate
    Department of Psychiatry and Psychotherapy, Municipal Hospital of Bremen, Germany
    Neuropsychology 17:420-8. 2003
    ..Second, the decline in the ability to alternate between different responses argues for a restricted neurotoxic effect of alcohol on some frontal lobe areas...
  9. ncbi Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS)
    Irene Guerrini
    Molecular Psychiatry Laboratory, Windeyer Institute of Medical Sciences, Department of Mental Health Sciences, Royal Free and University College London Medical School, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 137:17-9. 2005
  10. ncbi Acute Korsakoff syndrome following mammillothalamic tract infarction
    Yuichiro Yoneoka
    Department of Neurosurgery, Yamagata Prefecture Central Hospital, Yamagata, Japan
    AJNR Am J Neuroradiol 25:964-8. 2004
    There are limited case reports of structural lesions causing Korsakoff syndrome. This report describes acute Korsakoff syndrome following localized, bilateral infarction of the mammillothalamic tracts (MTTs)...
  11. doi Intact memory for implicit contextual information in Korsakoff's amnesia
    Erik Oudman
    Helmholtz Institute, Experimental Psychology, Utrecht University, Utrecht, The Netherlands
    Neuropsychologia 49:2848-55. 2011
    ..The implicit learning effect was not related to the spatial working memory scores. Together these results clearly suggest that implicit and explicit spatial memory have a different neurocognitive basis...
  12. doi Isolated prospective confabulation in Wernicke-Korsakoff syndrome: a case for reality filtering
    Armin Schnider
    Laboratory of Cognitive Neurorehabilitation, Department of Clinical Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    Neurocase 19:90-104. 2013
    ..amnesia and disorientation, accompanied by content-specific confabulation, due to an alcoholic Wernicke-Korsakoff syndrome. For months, he was deeply concerned about a single obligation that he thought he had to respond to, but ..
  13. doi Macrostructural abnormalities in Korsakoff syndrome compared with uncomplicated alcoholism
    A L Pitel
    INSERM, U1077, EPHE, UMR S1077, Caen, France
    Neurology 78:1330-3. 2012
    To distinguish, in patients with Korsakoff syndrome (KS), the structural brain abnormalities shared with alcoholic patients without KS (AL), from those specific to KS.
  14. doi Cholinergic dysfunction and amnesia in patients with Wernicke-Korsakoff syndrome: a transcranial magnetic stimulation study
    Raffaele Nardone
    Department of Neurology, Christian Doppler Clinic, Paracelsus Private Medical University, Salzburg, Austria
    J Neural Transm 117:385-91. 2010
    The specific neurochemical substrate underlying the amnesia in patients with Wernicke-Korsakoff syndrome (WKS) is still poorly defined. Memory impairment has been linked to dysfunction of neurons in the cholinergic system...
  15. ncbi A cluster of polyneuropathy and Wernicke-Korsakoff syndrome in a bariatric unit
    Luiz Claudio Lopes Chaves
    Obesity Surgery Group, Hospital Ofir Loyola, Belem, Para, Brazil
    Obes Surg 12:328-34. 2002
    Wernicke-Korsakoff syndrome and peripheral neuropathy are very uncommon in bariatric surgical practice. The literature indicates that these complications tend to strike patients receiving unbalanced diets or undergoing rapid weight-loss.
  16. pmc Spared unconscious influences of spatial memory in diencephalic amnesia
    Albert Postma
    Experimental Psychology, Helmholtz Institute, Utrecht University, Heidelberglaan 2, 3584 CS, Utrecht, The Netherlands
    Exp Brain Res 190:125-33. 2008
    ..The presented results suggest that conscious and unconscious influences of spatial memory can be clearly dissociated in Korsakoff's syndrome...
  17. ncbi Procedural memory in Korsakoff's disease under different movement feedback conditions
    Stephan P Swinnen
    Laboratory of Motor Control, Department of Kinesiology, Group Biomedical Sciences, K U Leuven, Tervuurse Vest 101, 3001 Leuven, Belgium
    Behav Brain Res 159:127-33. 2005
    ..This prompts for a reevaluation of current notions about procedural memory capacity in Korsakoff patients...
  18. ncbi A placebo-controlled study of memantine (Ebixa) in dementia of Wernicke-Korsakoff syndrome
    Avdo Rustembegovic
    Anton Proksch Institute, Department of Alcohol and Drug Dependence, Vienna, Austria
    Med Arh 57:149-50. 2003
    ..and tolerability of the memantine, and NMDA antagonist, in the treatment of dementia in Wernicke-Korsakoff syndrome. In this study, for the first time in dementia of Wernicke-Korsakoff syndrome, the response to memantine was ..
  19. ncbi [Particular aspects of bioelectric brain activity in post-traumatic Korsakoff syndrome]
    E R Obraztsova
    Zh Nevrol Psikhiatr Im S S Korsakova 103:59-65. 2003
    ..In the context of clinical data, this EEG phenomenon may be related to inhibited state of corresponding cortical areas...
  20. ncbi Spatial and temporal order memory in Korsakoff patients
    Albert Postma
    Psychological Laboratory, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands
    J Int Neuropsychol Soc 12:327-36. 2006
    ..Moreover, their lower recall of both features at the same time suggests that Korsakoff patients are impaired in binding different contextual attributes together in memory...
  21. ncbi Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre
    Clive Harper
    Department of Neuropathology, Institute for Clinical Neurosciences, Central Sydney Area Health Service, Camperdown, NSW, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 27:951-61. 2003
    ..The most significant of these is the alcohol-related vitamin deficient state, the Wernicke-Korsakoff syndrome (WKS), which is caused by thiamin deficiency but is seen most commonly in alcoholics...
  22. ncbi Spatial and non-spatial contextual working memory in patients with diencephalic or hippocampal dysfunction
    Carinne Piekema
    Helmholtz Institute, Utrecht University, The Netherlands
    Brain Res 1172:103-9. 2007
    ..However, we did not find a disproportionate inability in maintaining spatial or non-spatial associations within working memory as previously demonstrated in long-term memory...
  23. ncbi Acetylcholinesterase inhibitors for the treatment of Wernicke-Korsakoff syndrome--three further cases show response to donepezil
    Murray Cochrane
    Parkhead Hospital, 81 Salamanca Street, Glasgow, G31 5ES, UK
    Alcohol Alcohol 40:151-4. 2005
    Three patients diagnosed with Wernicke-Korsakoff syndrome were treated with the acetylcholinesterase inhibitor, donepezil, for periods of 6 to 8 months...
  24. ncbi Correlation between phosphorylation level of a hippocampal 86kDa protein and extinction of a behaviour in a model of Wernicke-Korsakoff syndrome
    Rita G W Pires
    Departamento de Bioquímica Imunologia, Laboratório de Neurociência Comportamental e Molecular LaNeC, Universidade Federal de Minas Gerais, Belo Horizonte 31270 010, Brazil
    Behav Brain Res 180:102-6. 2007
    ..These data add to and extend previous findings by our laboratory implicating the involvement of hippocampal neurotransmission components in extinction of a behaviour which involves learning of environmental spatial cues...
  25. ncbi FDG-PET findings in the Wernicke-Korsakoff syndrome
    Laurence J Reed
    University Dept of Psychiatry and Psychology, St Thomas s Hospital, Kings College, London, UK
    Cortex 39:1027-45. 2003
    ..Twelve patients suffering amnesia arising from the Korsakoff syndrome were compared with 10 control subjects without alcohol-related disability...
  26. ncbi Word frequency and word stem completion in Korsakoff patients
    H R Phaf
    Psychonomics Department, University of Amsterdam, The Netherlands
    J Clin Exp Neuropsychol 22:817-29. 2000
    ....
  27. ncbi Memory for object locations in Korsakoff's amnesia
    R P Kessels
    Psychological Laboratory, Utrecht University, The Netherlands
    Cortex 36:47-57. 2000
    ..No evidence for selective impairments could be observed. These impairments can be linked to damage of diencephalic regions and perhaps the parietal cortex...
  28. ncbi Functional MRI study of diencephalic amnesia in Wernicke-Korsakoff syndrome
    M Caulo
    Department of Clinical Sciences and Bio imaging, University G D Annunzio, Chieti Pescara, Italy
    Brain 128:1584-94. 2005
    Anterograde amnesia in Wernicke-Korsakoff syndrome is associated with diencephalic lesions, mainly in the anterior thalamic nuclei. Whether diencephalic and temporal lobe amnesias are distinct entities is still not clear...
  29. ncbi Spatial working memory and contextual cueing in patients with Korsakoff amnesia
    Marieke Van Asselen
    Psychological Laboratory, Helmholtz Instituut, Utrecht University, The Netherlands
    J Clin Exp Neuropsychol 27:645-55. 2005
    The current study investigated the effect of Korsakoff syndrome on memory for spatial information and, in particular, the effect of contextual cueing on spatial memory retention...
  30. pmc Structural MRI volumetric analysis in patients with organic amnesia, 1: methods and comparative findings across diagnostic groups
    A Colchester
    Neuro Media Group, KIMHS, Electrical Engineering Labs, University of Kent, Canterbury, Kent, CT2 7NT, UK
    J Neurol Neurosurg Psychiatry 71:13-22. 2001
    ..Previous neuroimaging reports in patients with Korsakoff syndrome have generally found widespread or non-specific change, whereas in patients with herpes encephalitis the ..
  31. pmc Neuroimaging of the Wernicke-Korsakoff syndrome
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Alcohol Alcohol 44:155-65. 2009
    ....
  32. ncbi [Trends in study of Wernicke-Korsakoff syndrome]
    Kenji Kosaka
    Seishin Shinkeigaku Zasshi 109:509-15. 2007
  33. ncbi The alcohol withdrawal syndrome
    A McKeon
    Department of Neurology and Clinical Neurosciences, Beaumont Hospital, Dublin, and Royal College of Surgeons in Ireland, Dublin, Ireland
    J Neurol Neurosurg Psychiatry 79:854-62. 2008
    ..Many patients with AWS have multiple management issues (withdrawal symptoms, delirium tremens, the Wernicke-Korsakoff syndrome, seizures, depression, polysubstance abuse, electrolyte disturbances and liver disease), which requires a ..
  34. pmc Alcohol and the nervous system
    C McIntosh
    Royal Edinburgh Hospital, Morningside Terrace, Edinburgh EH10 5HF, UK
    J Neurol Neurosurg Psychiatry 75:iii16-21. 2004
  35. pmc Reversible acute axonal polyneuropathy associated with Wernicke-Korsakoff syndrome: impaired physiological nerve conduction due to thiamine deficiency?
    S Ishibashi
    Department of Neurology and Neurological Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Neurol Neurosurg Psychiatry 74:674-6. 2003
    ..CMAPs, SNAPs, and SSRs also increased considerably. We suggest that this is a new type of peripheral nerve impairment: physiological conduction failure with minimal conduction delay due to thiamine deficiency...
  36. doi Severe dysphagia as the presenting symptom of Wernicke-Korsakoff syndrome in a non-alcoholic man
    Ilias Karaiskos
    Fourth Department of Internal Medicine, University of Athens Medical School Hospital Attikon, Attiki, Greece
    Neurol Sci 29:45-6. 2008
    ..and the dysphagia resolved, but the patient was left with a dense amnestic deficit consistent with Korsakoff syndrome. MRI at the time of the encephalopathy revealed lesions consistent with Wernicke-Korsakoff syndrome...
  37. ncbi Effect of kami-untan-to on the impairment of learning and memory induced by thiamine-deficient feeding in mice
    O Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Neuroscience 125:233-41. 2004
    ..These results suggest that the effect of KUT on the impairment of memory-related behavior induced by TD feeding may be closely related to the activation of cholinergic neurons in the hippocampus...
  38. doi Alcohol use, thiamine deficiency, and cognitive impairment
    Frances R Frankenburg
    JAMA 299:2854; author reply 2854-5. 2008
  39. ncbi Persistence of disturbed thalamic glucose metabolism in a case of Wernicke-Korsakoff syndrome
    Andreas Fellgiebel
    Department of Psychiatry, University Hospital of Mainz, Untere Zahlbacher Str 8, Mainz, Germany
    Psychiatry Res 124:105-12. 2003
    ..After admission, an amnestic syndrome with confabulation was also observed and diagnosis of Wernicke-Korsakoff syndrome was made...
  40. ncbi [Thiamine deficiency caused by malnutrition: a rare cause?]
    P G Jong Baw
    Parnassia Bavo Groep Den Haag
    Tijdschr Psychiatr 50:611-5. 2008
    ..If in doubt, always opt for thiamine suppletion...
  41. ncbi Disproportionate deficit in associative recognition relative to item recognition in global amnesia
    Kelly Sullivan Giovanello
    Boston University School of Medicine, Boston, Massachusetts, USA
    Cogn Affect Behav Neurosci 3:186-94. 2003
    ..These findings indicate that memory for novel associations between items is disproportionately impaired in comparison with memory for single items in amnesia...
  42. ncbi Enhanced head-twitch response to 5-HT-related agonists in thiamine-deficient mice
    O Nakagawasai
    Department of Pharmacology, Tohoku Pharmaceutical University, Sendai, Japan
    J Neural Transm 114:1003-10. 2007
    ..systems in neuro-psychiatric disorders such as schizophrenia and depression, their role in Wernicke-Korsakoff syndrome (WKS) remains unclear...
  43. ncbi Age-related vulnerability to diencephalic amnesia produced by thiamine deficiency: the role of time of insult
    Shane R Pitkin
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, NY 13905, USA
    Behav Brain Res 148:93-105. 2004
    ..A rodent model of Wernicke-Korsakoff Syndrome (WKS), acute pyrithiamine-induced thiamine deficiency (PTD), produces diencephalic damage and impairments of ..
  44. pmc The anatomy of amnesia: neurohistological analysis of three new cases
    Jeffrey J Gold
    Veterans Affairs Medical Center, San Diego, California 92161, USA
    Learn Mem 13:699-710. 2006
    ..These findings illuminate several issues regarding the relation between diencephalic and medial temporal lobe amnesia, the status of recognition memory in amnesia, and the neuroanatomy of memory...
  45. ncbi Voxel-based mapping of brain hypometabolism in permanent amnesia with PET
    A M Aupée
    INSERM U320, Cyceron and Department of Neurology, University of Caen, France
    Neuroimage 13:1164-73. 2001
    ..The use of a voxel-based method allowed us to map a common network of synaptic dysfunction in a neuropsychological syndrome regardless of etiology. Our results indicate that this should be a powerful method in functional neuropsychology...
  46. ncbi Development and resolution of brain lesions caused by pyrithiamine- and dietary-induced thiamine deficiency and alcohol exposure in the alcohol-preferring rat: a longitudinal magnetic resonance imaging and spectroscopy study
    Adolf Pfefferbaum
    Neuroscience Program, SRI International, Menlo Park, CA, USA
    Neuropsychopharmacology 32:1159-77. 2007
    ....
  47. ncbi The natural history and pathophysiology of Wernicke's Encephalopathy and Korsakoff's Psychosis
    Allan D Thomson
    Molecular Psychiatry Laboratory, Windeyer Institute of Medical Sciences, Department of Mental Health Sciences, Royal Free and University College, London Medical School, London UK
    Alcohol Alcohol 41:151-8. 2006
    ..It is hoped that this will highlight the need for clinicians to treat alcohol-dependent patients prophylactically with parenteral thiamine and thus prevent the development of Korsakoff's Psychosis (KP)...
  48. ncbi The current state of S. S. Korsakov's concept of alcoholic polyneuritic psychosis
    Yu P Sivolap
    Department of Psychiatry and Medical Psychology, I M Sechenov Moscow Medical Academy, Russia
    Neurosci Behav Physiol 35:977-82. 2005
  49. ncbi Temporal order memory in patients with Korsakoff's syndrome and medial temporal amnesia
    John Joseph Downes
    Department of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool L69 72A, UK
    Neuropsychologia 40:853-61. 2002
    ....
  50. pmc Blunted hippocampal, but not striatal, acetylcholine efflux parallels learning impairment in diencephalic-lesioned rats
    Jessica J Roland
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University SUNY, Binghamton, NY 13902, USA
    Neurobiol Learn Mem 87:123-32. 2007
    ..The results support selective diencephalic-hippocampal dysfunction in the PTD model. This diencephalic-hippocampal interaction appears to be critical for successful episodic and spatial learning/memory...
  51. ncbi Cholinergic parameters and the retrieval of learned and re-learned spatial information: a study using a model of Wernicke-Korsakoff Syndrome
    Rita G W Pires
    Departamento de Bioquímica Imunologia, Laboratório de Neurociência e Comportamento, Universidade Federal de Minas Gerais, Belo Horizonte 31270 010, Brazil
    Behav Brain Res 162:11-21. 2005
    ..But the correlation with the behavioural parameters was observed only for pre-trained animals, that is, those that were retrained and assessed for retrograde retention...
  52. ncbi Perceptual learning in amnesia
    Manfred Fahle
    Department of Human Neurobiology, University of Bremen, Argonnenstr 3, D 28211 Bremen, Germany
    Neuropsychologia 40:1167-72. 2002
    ..This result corroborates the notion of a relatively 'front end' location of at least some forms of perceptual learning...
  53. ncbi Nerve growth factor in serum is a marker of the stage of alcohol disease
    Maria C Jockers-Scherübl
    Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Neurosci Lett 419:78-82. 2007
    ..In accordance with this hypothesis, NGF values are "normal" in patients with persistent alcohol-related cognitive decline...
  54. ncbi Is implicit learning spared in amnesia? Rule abstraction and item familiarity in artificial grammar learning
    Shelley Channon
    Subdepartment of Clinical Health Psychology, University College London, Gower Street, UK
    Neuropsychologia 40:2185-97. 2002
    ..However, this sensitivity to bigram familiarity was significantly reduced in the amnesic compared to the control group. The results challenge the claim that implicit learning is intact in amnesia...
  55. ncbi The National Adult Reading Test as a measure of premorbid intelligence: a comparison with estimates derived from demographic variables
    Peter Bright
    University Department of Psychiatry and Psychology, King s College, London, UK
    J Int Neuropsychol Soc 8:847-54. 2002
    ..The data offer reassurance regarding the continued use of NART as a valid estimate of premorbid intelligence in a number of conditions...
  56. ncbi [Wernicke-Korsakoff syndrome: malignant tumour as triggering factor]
    J Guisado
    , Facultad de Medicina, Universidad de Extremadura, Badajoz
    Actas Esp Psiquiatr 29:279-81. 2001
    ..alcoholism and malignant tumour are three predisponing risk factors for the development of Wernicke-Korsakoff syndrome. We described the clinical case of a patient with history of alcoholism that developed Wernicke-Korsakoff ..
  57. doi [Wernicke encephalopathy after subtotal gastrectomy for morbid obesity]
    C Gabaudan
    Service d Imagerie Medicale, hôpital Laveran, boulevard Laveran, 13013 Marseille, France
    Rev Neurol (Paris) 164:463-7. 2008
    ..The interest of nutritional supervision in the first weeks and preventive thiamine supplementation in case of repeated vomiting are of particular importance in these risky situations...
  58. ncbi The effect of retrieval instructions on false recognition: exploring the nature of the gist memory impairment in amnesia
    Mieke Verfaellie
    Memory Disorders Research Center 151A, Boston VA Healthcare System, 150 S Huntington Avenue, Boston, MA 02130, USA
    Neuropsychologia 40:2360-8. 2002
    ..Rather, it suggests that amnesic patients are impaired in their ability to encode, store, or maintain strong gist information...
  59. doi Confabulation behavior and false memories in Korsakoff's syndrome: role of source memory and executive functioning
    Roy P C Kessels
    Nijmegen Institute for Cognition and Information, Radboud University Nijmegen, The Netherlands
    Psychiatry Clin Neurosci 62:220-5. 2008
    ..Provoked confabulations may be related to intrusions on memory tests, whereas spontaneous confabulations may be due to executive dysfunction or a source memory deficit...
  60. ncbi Wernicke-Korsakoff syndrome and galantamine
    B Kirk Phillips
    Psychosomatics 45:366-8. 2004
  61. ncbi Decision-making deficits of korsakoff patients in a new gambling task with explicit rules: associations with executive functions
    Matthias Brand
    Department of Physiological Psychology, University of Bielefeld, Bielefeld, Germany
    Neuropsychology 19:267-77. 2005
    ..Results show that Korsakoff patients are strongly impaired in this explicit decision-making task and that these disturbances are correlated with specific executive functions...
  62. ncbi [Neuropsychology of Korsakoff's syndrome]
    J Cabanyes
    Departamento de Neurologia, Clinica Salvia, Madrid
    Neurologia 19:183-92. 2004
    ..The aim of this paper is to review the most important neuropsychological features of Korsakoff's syndrome and to discuss the hypotheses on it...
  63. ncbi [Neuropsychological deficits in alcoholics: some implications for road safety]
    M J Garrido
    Departamento de Psicología Básica II, Universidad Complutense, Madrid, Espana
    Rev Neurol 38:277-83. 2004
    ..We also will analyse the involvement of these deficit in a complex task as driving...
  64. doi Alcohol, cognitive impairment and the hard to discharge acute hospital inpatients
    A Popoola
    Professorial Psychiatric Unit, Cork University Hospital, Cork, Ireland
    Ir J Med Sci 177:141-5. 2008
    ..To examine the role of alcohol and alcohol-related cognitive impairment in the clinical presentation of adults in-patients less than 65 years who are 'hard to discharge' in a general hospital...
  65. ncbi No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome
    S Matsushita
    Department of Clinical Research, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa, Japan
    Neurobiol Aging 22:569-74. 2001
    ..Also characterized by reduced KGDHC activity is another neuropsychiatric disease, Wernicke-Korsakoff syndrome (WKS), which results from thiamine deficiency...
  66. ncbi Frontal dysfunction and frontal cortical synapse loss in alcoholism--the main cause of alcohol dementia?
    A Brun
    Department of Forensic Medicine, Lund, Sweden
    Dement Geriatr Cogn Disord 12:289-94. 2001
    ..The cortical changes are closely similar to those found in frontotemporal dementia, and seem to be a plausible main cause of the alcoholic frontal symptomatology and alcoholic dementia...
  67. doi Episodic and working memory deficits in alcoholic Korsakoff patients: the continuity theory revisited
    Anne Lise Pitel
    Inserm EPHE Universite de Caen Basse Normandie, Unité U923, GIP Cyceron, CHU Cote de Nacre, Caen, France
    Alcohol Clin Exp Res 32:1229-41. 2008
    ....
  68. ncbi The cost of living in purgatory's shadow
    Michael S Vaphiades
    The Departments of Ophthalmology, Neurology and Neurosurgery, University of Alabama Birmingham, USA
    J Ark Med Soc 101:146-7. 2004
    A 40-year-old alcoholic man developed Wernicke-Korsakoff syndrome. His examination showed ophthalmoplegia, ataxia and memory difficulties...
  69. ncbi Bright red nuclei
    Laurence J Kinsella
    Neurology 63:1543; author reply 1543. 2004
  70. ncbi Dramatic recovery from prolonged Wernicke-Korsakoff disease
    Antonio Carota
    Service de Rééducation, Hopital Cantonal Universitaire, Geneve, Suisse
    Eur Neurol 53:45-6. 2005
  71. ncbi Thiamine pyrophosphate-requiring enzymes are altered during pyrithiamine-induced thiamine deficiency in cultured human lymphoblasts
    S R Pekovich
    Department of Molecular Biology, Vanderbilt University, Nashville, TN 37325, USA
    J Nutr 126:1791-8. 1996
    The most common of the severe complications of thiamine deficiency are beriberi and Wernicke-Korsakoff syndrome. To help clarify the biochemical basis for these disorders, a cell culture system has been established in which pyrithiamine, ..
  72. ncbi Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus callosum ultrastructure
    Xiaohua He
    Department of Pathology D06, University of Sydney, Sydney, NSW 2006, Australia
    Neuropsychopharmacology 32:2207-16. 2007
    ..and thiamine deficiency in causing brain damage remain controversial in alcoholics without the Wernicke-Korsakoff syndrome. Experimental control over alcohol consumption and diet are impossible in humans but can be accomplished in ..
  73. ncbi Optimum nutrition: thiamin, biotin and pantothenate
    D A Bender
    Department of Biochemistry and Molecular Biology, University College London, UK
    Proc Nutr Soc 58:427-33. 1999
    ..2.1.1) is the thiamin-dependent step. It has been suggested that the Wernicke-Korsakoff syndrome is associated with a genetic variant of transketolase which requires a higher than normal concentration of ..
  74. pmc Impaired, spared, and enhanced ACh efflux across the hippocampus and striatum in diencephalic amnesia is dependent on task demands
    Ryan P Vetreno
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University, State University of New York, Binghamton, NY 13902, USA
    Neurobiol Learn Mem 90:237-44. 2008
    ..brain lesions and impairments similar in nature and distribution to those observed in humans with Wernicke-Korsakoff syndrome (WKS)...
  75. ncbi Cloning of human transketolase cDNAs and comparison of the nucleotide sequence of the coding region in Wernicke-Korsakoff and non-Wernicke-Korsakoff individuals
    B A McCool
    Department of Molecular Biology, Vanderbilt University, Nashville, Tennessee 37235
    J Biol Chem 268:1397-404. 1993
    ..thiamine pyrophosphate (high apparent Km) have been described in chronic alcoholic patients with Wernicke-Korsakoff syndrome. Since the syndrome has been shown to be directly related to thiamine deficiency, it has been hypothesized ..
  76. pmc Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans
    Liesbeth de Jong
    Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
    Genetics 168:845-54. 2004
    ..in the diet of animals, and thiamine deficiency leads to diseases such as beri-beri and the Wernicke-Korsakoff syndrome. Dietary thiamine (vitamin B1) consists mainly of thiamine pyrophosphate (TPP), which is transformed into ..
  77. ncbi The psychiatric management of patients with alcohol dependence
    Jonathan I Ritvo
    Charles Park, MD Department of Psychiatry, University of Hawaii, 1356 Lusitana Street, UH Tower, Fourth Floor, Honolulu, HI 96813, USA
    Curr Treat Options Neurol 9:381-92. 2007
    ..administration of intravenous fluids to prevent the development of Wernicke's encephalopathy and Wernicke-Korsakoff syndrome. In combination with psychosocial treatment, disulfiram, naltrexone, and acamprosate can reduce the ..
  78. ncbi [Beriberi after bariatric surgery: not an unusual complication. Report of two cases and literature review]
    Lilian F A Alves
    Servico de Endocrinologia, Hospital Felicio Rocho, Rua Monte Alegre 851, 30240 230 Belo Horizonte, MG
    Arq Bras Endocrinol Metabol 50:564-8. 2006
    ..Two patients with the clinic of peripheral neuropathy and Wernicke-Korsakoff syndrome will be reported...
  79. ncbi B Vitamin deficiency and neuropsychiatric syndromes in alcohol misuse
    C C Cook
    Kent Institute of Medicine and Health Sciences, University of Kent at Canterbury, UK
    Alcohol Alcohol 33:317-36. 1998
    ..In particular, the Wernicke Korsakoff syndrome (WKS)...
  80. doi Molecular genetics of alcohol-related brain damage
    Irene Guerrini
    Bexley Substance Misuse Service, South London and Mausdley NHS Trust, London, UK
    Alcohol Alcohol 44:166-70. 2009
    ..The aim of this paper is to review the most recent knowledge on the genetic susceptibility to the development of alcohol-related Wernicke-Korsakoff syndrome (WKS).
  81. doi Elevated cerebrospinal fluid tau protein levels in Wernicke's encephalopathy
    Sachio Matsushita
    National Hospital Organization, Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan
    Alcohol Clin Exp Res 32:1091-5. 2008
    ..CSF total tau protein in patients with WE, as well as in those with alcohol withdrawal delirium (WD) and Korsakoff syndrome (KS)...
  82. pmc Blocking GABA-A receptors in the medial septum enhances hippocampal acetylcholine release and behavior in a rat model of diencephalic amnesia
    Jessica J Roland
    Behavioral Neuroscience Program, Department of Psychology, Binghamton University State University of New York, NY, USA
    Pharmacol Biochem Behav 92:480-7. 2009
    Wernicke-Korsakoff syndrome (WKS), a form of diencephalic amnesia caused by thiamine deficiency, results in severe anterograde memory loss...
  83. pmc Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells
    Marjorie Gangolf
    GIGA Neurosciences, University of Liege, Liege, Belgium
    PLoS ONE 5:e13616. 2010
    ..Diseases linked to thiamine deficiency (polyneuritis, Wernicke-Korsakoff syndrome) remain frequent among alcohol abusers and other risk populations...
  84. ncbi Persistence of habituation deficits after neurological recovery from severe thiamine deprivation
    K Le Roch
    Departement de Psychophysiologie, C N R S, Gif sur Yvette, France
    Behav Brain Res 26:37-46. 1987
    ..These symptoms are reminiscent of the clinical Wernicke-Korsakoff syndrome. Injection of thiamine dramatically reversed these symptoms within one or two hours as seen in Wernicke ..
  85. ncbi Neurological complications of prolonged hunger strike
    M Basoglu
    Neurology Department, Ataturk Training and Research Hospital, Izmir, Turkey
    Eur J Neurol 13:1089-97. 2006
    ..for 60-294 days (mean 156) during the hunger strike, and had neurological findings consistent with Wernicke-Korsakoff syndrome. All 41 patients exhibited altered consciousness which lasted from 3 to 31 days...
  86. doi Anthocyanins: are they beneficial in treating ethanol neurotoxicity?
    Gang Chen
    Department of Internal Medicine, College of Medicine, University of Kentucky, 124C Combs Research Building, 800 Rose Street, Lexington, KY, 40536, USA
    Neurotox Res 17:91-101. 2010
    ..Excessive alcohol consumption is associated with Wernicke-Korsakoff syndrome (WKS) and neurodegeneration in the adult brain...
  87. doi Confabulations in alcoholic Korsakoff patients
    Sabine Borsutzky
    Physiological Psychology, University of Bielefeld, Bielefeld, Germany
    Neuropsychologia 46:3133-43. 2008
    ..Although confabulations are described anecdotally in patients with alcoholic Korsakoff syndrome (KS), there are few systematic investigations of the presence and nature of these types of false memories in ..
  88. ncbi Wernicke's encephalopathy in a malnourished surgical patient: clinical features and magnetic resonance imaging
    M Nolli
    Anaesthesia Unit, Department of Emergency and Critical Area, General Hospital La Spezia, Italy
    Acta Anaesthesiol Scand 49:1566-70. 2005
    ..This progressed to typical Wernicke-Korsakoff syndrome with ataxia and memory and cognitive defects...
  89. ncbi The glutamatergic basis of human alcoholism
    G Tsai
    Laboratory of Molecular and Developmental Neuroscience, Massachusetts General Hospital
    Am J Psychiatry 152:332-40. 1995
    ..Neurobiological effects of alcoholism, such as intoxication, withdrawal seizures, delirium tremens, Wernicke-Korsakoff syndrome, and fetal alcohol syndrome, can be understood as a spectrum of consequences of ethanol's effect on the ..
  90. ncbi Neuromuscular consequences of prolonged hunger strike: an electrophysiological study
    A E Oge
    Department of Neurology, Istanbul University, Istanbul Faculty of Medicine, Capa 34390, Istanbul, Turkey
    Clin Neurophysiol 111:2064-70. 2000
    ..The purpose of this study was to determine the electrophysiological consequences of neuromuscular and central nervous system involvement in a group of patients presented with the neurological complications of a long-term hunger strike (HS)...
  91. pmc Lithium-mediated protection against ethanol neurotoxicity
    Jia Luo
    Department of Internal Medicine, University of Kentucky College of Medicine Lexington, KY, USA
    Front Neurosci 4:41. 2010
    ..Excessive alcohol consumption is also associated with Wernicke-Korsakoff syndrome and neurodegeneration in the adult brain...
  92. ncbi Persistent altered mentation due to ethanol
    M Victor
    Department of Medicine Neurology, Dartmouth Medical School, Hanover, New Hampshire
    Neurol Clin 11:639-61. 1993
    ..The dementing diseases of Wernicke-Korsakoff syndrome, pellagra, the nonfamilial form of hepatocerebral degeneration, Marchiafava-Bignami disease, and alcoholic ..
  93. ncbi Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase
    M Abedinia
    Department of Biochemistry, University of Queensland, Brisbane, Australia
    Biochem Biophys Res Commun 183:1159-66. 1992
    ..in the pentose-phosphate pathway which has been implicated in the latent human genetic disease, Wernicke-Korsakoff syndrome. Here we report the cloning and partial characterisation of the coding sequences encoding human ..
  94. ncbi The neurotoxicity of alcohol
    Clive Harper
    Department of Pathology, Blackburn Building, D06, University of Sydney, NSW 2006, Australia
    Hum Exp Toxicol 26:251-7. 2007
    ..and other brain regions damaged in patients who have additional vitamin B1 (thiamine) deficiency (Wernicke-Korsakoff syndrome)...
  95. pmc Anorexia nervosa and Wernicke-Korsakoff syndrome: a case report
    Laura Saad
    Department of Psychiatry, Faculty of Medical Sciences, University of Campinas UNICAMP, PO Box 6111, Campinas, SP Brazil, ZIP code 13081 970
    J Med Case Reports 4:217. 2010
    ..Wernicke's encephalopathy has traditionally been associated with alcoholism but, in recent years, there has been an increase in the number of clinical settings in which the disorder is observed...
  96. ncbi Memory for subject performed tasks in patients with Korsakoff syndrome
    M Mimura
    Department of Neuropsychiatry, Tokyo Dental College Ichikawa General Hospital
    Cortex 34:297-303. 1998
    ..Domains preserved in this amnesic syndrome may account for the benefit seen when using SPTs in Korsakoff patients. The therapeutic utilization of action events for memory rehabilitation is discussed...
  97. ncbi Cognitive performance of detoxified alcoholic Korsakoff syndrome patients remains stable over two years
    Esther Fujiwara
    Physiological Psychology, University of Bielefeld, Bielefeld, Germany
    J Clin Exp Neuropsychol 30:576-87. 2008
    ..However, little is known about the time course of cognitive functions in patients with chronic alcoholic Korsakoff syndrome (KS)...
  98. ncbi Stroke and seizure following a recent laparoscopic Roux-en-Y gastric bypass
    John Y Choi
    Department of Neurology, University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Obes Surg 14:857-60. 2004
    ..Neurologic complications have occurred, such as polyneuropathy and Wernicke-Korsakoff syndrome. We report an 18-year-old female with morbid obesity, steatohepatitis, tobacco, recreational drug, and oral ..
  99. ncbi Wernicke-Korsakoff syndrome following attempted hanging
    K Schmidtke
    , , Germany
    Rev Neurol (Paris) 149:213-6. 1993
    ..Precipitation of the disease is attributed to the synergetic effect of cerebral hypoxia/ischemia and thiamine deficiency...
  100. pmc Prevalence of Wernicke-Korsakoff syndrome in Australia: has thiamine fortification made a difference?
    C G Harper
    Department of Pathology, University of Sydney, NSW
    Med J Aust 168:542-5. 1998
    To determine the prevalence of the Wernicke-Korsakoff syndrome (WKS) in Australia and compare this with previous studies.
  101. ncbi Memory and action: an experimental study on normal subjects and schizophrenic patients
    Elena Daprati
    Dipartimento di Fisiologia Neuromotoria, IRCCS Fondazione Santa Lucia, Via Ardeatina, 354, I 00179 Rome, Italy
    Neuropsychologia 43:281-93. 2005
    ..i.e. Alzheimer disease. Memory for subject performed tasks in patients with Korsakoff syndrome. The present study attempts to evaluate whether pure motor activity is sufficient to guarantee the described ..

Research Grants70

  1. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2007
    ..e., nonamnesic) alcoholics appear as a graded version of those seen when WE progresses to the amnesic Korsakoff syndrome (KS or WKS)...
  2. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2010
    ..e., nonamnesic) alcoholics appear as a graded version of those seen when WE progresses to the amnesic Korsakoff syndrome (KS or WKS)...
  3. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2009
    ..e., nonamnesic) alcoholics appear as a graded version of those seen when WE progresses to the amnesic Korsakoff syndrome (KS or WKS)...
  4. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2010
    ..e., nonamnesic) alcoholics appear as a graded version of those seen when WE progresses to the amnesic Korsakoff syndrome (KS or WKS)...
  5. CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISM
    Adolf Pfefferbaum; Fiscal Year: 2009
    ..e., nonamnesic) alcoholics appear as a graded version of those seen when WE progresses to the amnesic Korsakoff syndrome (KS or WKS)...
  6. Hippocampus/Pituitary Ratio: an AD Brain Injury Marker?
    Thomas Beresford; Fiscal Year: 2005
    ..Others found such neuro-endocrine abnormalities more frequently among Wernicke-Korsakoff Syndrome cases, suggesting a possible relation to brain injury...
  7. MEMORY AS AFFECTED BY AGING, DISEASE AND ECT
    Larry Squire; Fiscal Year: 1980
    ..A., and in patients with Korsakoff syndrome. A second objective is to compare the amnesic syndrome to the memory impairment associated with depression, ..
  8. Effects of Repetition on Learning and Memory in Amnesia
    Mieke Verfaellie; Fiscal Year: 2007
    ....
  9. BRAIN-INJURY MEMORY DISORDERS RESEARCH CENTER
    Mieke Verfaellie; Fiscal Year: 2003
    ..The interactions between the investigators from the five investigative components supported by the core programs constitute the fabric of our Center. ..
  10. BRAIN TISSUE RESOURCE CENTER FOR ALCOHOL RESEARCH
    Clive Harper; Fiscal Year: 2002
    ..A "bank" of this type is necessarily a long-term project and the maximum benefits will be seen as case numbers increase and subgroups of cases (eg males versus females) can be selectively studied. ..
  11. IMPAIRED AND PRESERVED MEMORY PROCESSES IN AMNESIA
    Mieke Verfaellie; Fiscal Year: 2002
    ....
  12. Effects of Repetition on Learning and Memory in Amnesia
    Mieke H Verfaellie; Fiscal Year: 2010
    ....
  13. Effects of Repetition on Learning and Memory in Amnesia
    Mieke Verfaellie; Fiscal Year: 2009
    ....
  14. Brain Tissue Resource Centre for Alcohol Research
    Clive Harper; Fiscal Year: 2007
    ..Funding is sought to help further develop this important resource for international researchers with an interest in alcohol-related brain damage. ..
  15. IMPAIRED AND PRESERVED MEMORY PROCESSES IN AMNESIA
    Mieke Verfaellie; Fiscal Year: 2007
    ..abstract_text> ..
  16. The Role of Acetylcholine Dysfunction in Diencephalic Amnesia
    Lisa Savage; Fiscal Year: 2009
    ..Such experiments are critical to understanding the role of acetylcholine dysfunction in amnesia and thus the development of pharmacotherapeutics. ..
  17. The Role of Acetylcholine Dysfunction in Diencephalic Amnesia
    Lisa Savage; Fiscal Year: 2009
    ..Such experiments are critical to understanding the role of acetylcholine dysfunction in amnesia and thus the development of pharmacotherapeutics. ..
  18. The Role of Acetylcholine Dysfunction in Diencephalic Amnesia
    Lisa M Savage; Fiscal Year: 2010
    ..Such experiments are critical to understanding the role of acetylcholine dysfunction in amnesia and thus the development of pharmacotherapeutics. ..
  19. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    Edith Sullivan; Fiscal Year: 2009
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  20. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    EDITH VIONI SULLIVAN; Fiscal Year: 2010
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  21. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    Edith Sullivan; Fiscal Year: 2004
    ....
  22. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2003
    ..abstract_text> ..
  23. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2007
    ..systems in excess of those recruited by controls, and this would have the untoward outcome of reducing processing capacity available for simultaneous performance of other tasks, including maintenance of postural stability ..
  24. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    Edith Sullivan; Fiscal Year: 2007
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  25. REGULATION OF DEVELOPMENT BY PHOSPHORELAY SIGNALING
    CHARLES SINGLETON; Fiscal Year: 2002
    ..Finally genetic screens for suppressers or synthetic phenotypes will identify new and perhaps novel components of the regulatory pathway, including upstream inputs, phosphorelay regulators, and downstream effectors. ..