motivation

Summary

Summary: Those factors which cause an organism to behave or act in either a goal-seeking or satisfying manner. They may be influenced by physiological drives or by external stimuli.

Top Publications

  1. ncbi Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being
    R M Ryan
    Department of Clinical and Social Sciences in Psychology, University of Rochester, Rochester, NY 14627, USA
    Am Psychol 55:68-78. 2000
  2. pmc Motivation and retention of health workers in developing countries: a systematic review
    Mischa Willis-Shattuck
    Centre for Global Health, Trinity College Dublin, Dublin 2, Ireland
    BMC Health Serv Res 8:247. 2008
  3. pmc Increasing response rates to postal questionnaires: systematic review
    Phil Edwards
    CRASH Trial Co ordinating Centre, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1B 1DP
    BMJ 324:1183. 2002
  4. ncbi Discrete coding of reward probability and uncertainty by dopamine neurons
    Christopher D Fiorillo
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 299:1898-902. 2003
  5. ncbi The debate over dopamine's role in reward: the case for incentive salience
    Kent C Berridge
    Department of Psychology, University of Michigan, 530 Church Street East Hall, Ann Arbor, MI 48109, USA
    Psychopharmacology (Berl) 191:391-431. 2007
  6. ncbi Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neurosci Biobehav Rev 26:321-52. 2002
  7. ncbi Emotion and motivation I: defensive and appetitive reactions in picture processing
    M M Bradley
    Center for the Study of Emotion and Attention, Health Sciences Center, University of Florida, Gainesville 32610-0165, USA
    Emotion 1:276-98. 2001
  8. pmc Two types of dopamine neuron distinctly convey positive and negative motivational signals
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    Nature 459:837-41. 2009
  9. ncbi Motivational "spill-over" during weight control: increased self-determination and exercise intrinsic motivation predict eating self-regulation
    Jutta Mata
    Department of Exercise and Health, Faculty of Human Kinetics, Technical University of Lisbon, Cruz Quebrada, Portugal
    Health Psychol 28:709-16. 2009
  10. ncbi Dissociation of reward anticipation and outcome with event-related fMRI
    B Knutson
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892-1610, USA
    Neuroreport 12:3683-7. 2001

Detail Information

Publications370 found, 100 shown here

  1. ncbi Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being
    R M Ryan
    Department of Clinical and Social Sciences in Psychology, University of Rochester, Rochester, NY 14627, USA
    Am Psychol 55:68-78. 2000
    ..has focused on the social-contextual conditions that facilitate versus forestall the natural processes of self-motivation and healthy psychological development...
  2. pmc Motivation and retention of health workers in developing countries: a systematic review
    Mischa Willis-Shattuck
    Centre for Global Health, Trinity College Dublin, Dublin 2, Ireland
    BMC Health Serv Res 8:247. 2008
    ..The authors undertook a systematic review to consolidate existing evidence on the impact of financial and non-financial incentives on motivation and retention.
  3. pmc Increasing response rates to postal questionnaires: systematic review
    Phil Edwards
    CRASH Trial Co ordinating Centre, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1B 1DP
    BMJ 324:1183. 2002
    ..To identify methods to increase response to postal questionnaires...
  4. ncbi Discrete coding of reward probability and uncertainty by dopamine neurons
    Christopher D Fiorillo
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 299:1898-902. 2003
    ..The coding of uncertainty suggests a possible role for dopamine signals in attention-based learning and risk-taking behavior...
  5. ncbi The debate over dopamine's role in reward: the case for incentive salience
    Kent C Berridge
    Department of Psychology, University of Michigan, 530 Church Street East Hall, Ann Arbor, MI 48109, USA
    Psychopharmacology (Berl) 191:391-431. 2007
    ..Results from studies that exploited those opportunities are described here...
  6. ncbi Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neurosci Biobehav Rev 26:321-52. 2002
    ....
  7. ncbi Emotion and motivation I: defensive and appetitive reactions in picture processing
    M M Bradley
    Center for the Study of Emotion and Attention, Health Sciences Center, University of Florida, Gainesville 32610-0165, USA
    Emotion 1:276-98. 2001
    ....
  8. pmc Two types of dopamine neuron distinctly convey positive and negative motivational signals
    Masayuki Matsumoto
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    Nature 459:837-41. 2009
    ..A similar anatomical difference was observed for their responses to actual airpuffs. These findings suggest that different groups of dopamine neurons convey motivational signals in distinct manners...
  9. ncbi Motivational "spill-over" during weight control: increased self-determination and exercise intrinsic motivation predict eating self-regulation
    Jutta Mata
    Department of Exercise and Health, Faculty of Human Kinetics, Technical University of Lisbon, Cruz Quebrada, Portugal
    Health Psychol 28:709-16. 2009
    ..Based on the Hierarchical Model of Motivation the authors examined whether exercise-specific motivation can transfer to eating regulation during a lifestyle ..
  10. ncbi Dissociation of reward anticipation and outcome with event-related fMRI
    B Knutson
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892-1610, USA
    Neuroreport 12:3683-7. 2001
    ..These findings suggest that reward anticipation and outcomes may differentially recruit distinct regions that lie along the trajectory of ascending dopamine projections...
  11. ncbi Building a practically useful theory of goal setting and task motivation. A 35-year odyssey
    Edwin A Locke
    R H Smith School of Business, University of Maryland, USA
    Am Psychol 57:705-17. 2002
    ..The relationships of goal setting to other theories are described as are the theory's limitations...
  12. pmc How do emotion and motivation direct executive control?
    Luiz Pessoa
    Department of Psychological and Brain Sciences, Indiana University, 1101 E10th Street, Bloomington, IN 47505, USA
    Trends Cogn Sci 13:160-6. 2009
    Emotion and motivation have crucial roles in determining human behavior. Yet, how they interact with cognitive control functions is less understood...
  13. ncbi Parsing reward
    Kent C Berridge
    Department of Psychology, Biopsychology Program, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Trends Neurosci 26:507-13. 2003
    ..conditioning and cognitive processes); (2) affect or emotion (implicit 'liking' and conscious pleasure) and (3) motivation (implicit incentive salience 'wanting' and cognitive incentive goals)...
  14. pmc Dissecting components of reward: 'liking', 'wanting', and learning
    Kent C Berridge
    Department of Psychology, University of Michigan, Ann Arbor, 48109 1043, USA
    Curr Opin Pharmacol 9:65-73. 2009
    ..of reward, and their neurobiological substrates, may help in devising improved treatments for disorders of mood and motivation, ranging from depression to eating disorders, drug addiction, and related compulsive pursuits of rewards.
  15. ncbi Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits
    J D Salamone
    Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT, 06269 1020, USA
    Psychopharmacology (Berl) 191:461-82. 2007
    ..restructuring, such that the classic emphasis on hedonia and primary reward is giving way to diverse lines of research that focus on aspects of instrumental learning, reward prediction, incentive motivation, and behavioral activation.
  16. ncbi Dissociable neural responses in human reward systems
    R Elliott
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 20:6159-65. 2000
    ..These results demonstrate dissociable neural responses to rewards and penalties that are dependent on the psychological context in which they are experienced...
  17. ncbi Computer-tailored health interventions delivered over the Web: review and analysis of key components
    Mia Liza A Lustria
    College of Information, Florida State University, 270 Louis Shores Building, Tallahassee, FL 32306 2100, United States
    Patient Educ Couns 74:156-73. 2009
    ..This systematic review explores how computer-tailored, behavioral interventions implemented and delivered via the Web have been operationalized in a variety of settings...
  18. pmc The social motivation theory of autism
    Coralie Chevallier
    Center for Autism Research, Children s Hospital of Philadelphia, 3535 Market Street, Philadelphia, PA 19104, USA
    Trends Cogn Sci 16:231-9. 2012
    The idea that social motivation deficits play a central role in Autism Spectrum Disorders (ASD) has recently gained increased interest...
  19. ncbi Behavioral theories and the neurophysiology of reward
    Wolfram Schultz
    Department of Anatomy, University of Cambridge, CB2 3DY United Kingdom
    Annu Rev Psychol 57:87-115. 2006
    ..The neural activity can be related to basic theoretical terms of reward and uncertainty, such as contiguity, contingency, prediction error, magnitude, probability, expected value, and variance...
  20. ncbi Addiction
    Terry E Robinson
    Department of Psychology Biopsychology Program, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
    Annu Rev Psychol 54:25-53. 2003
    ..view, which suggests that sensitization of a neural system that attributes incentive salience causes compulsive motivation or "wanting" to take addictive drugs; and (d) the idea that dysfunction of frontal cortical systems, which ..
  21. ncbi Tonic dopamine: opportunity costs and the control of response vigor
    Yael Niv
    Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel
    Psychopharmacology (Berl) 191:507-20. 2007
    ....
  22. pmc Motivational interviewing: a systematic review and meta-analysis
    Sune Rubak
    Department and Research Unit of General Practice, University of Aarhus, Denmark
    Br J Gen Pract 55:305-12. 2005
    ..Motivational Interviewing is a well-known, scientifically tested method of counselling clients developed by Miller and Rollnick and viewed as a useful intervention strategy in the treatment of lifestyle problems and disease...
  23. ncbi Assessing competence in the use of motivational interviewing
    Theresa B Moyers
    Center on Alcoholism, Substance Abuse, and Addictions, University of New Mexico, Albuquerque, NM, USA
    J Subst Abuse Treat 28:19-26. 2005
    ..Implications for the use of this instrument in research and supervision are discussed...
  24. ncbi Motivational interviewing
    Jennifer Hettema
    Department of Psychology, University of New Mexico, Albuquerque, New Mexico 87131 1161, USA
    Annu Rev Clin Psychol 1:91-111. 2005
    ..Progress toward a theory of MI is described, as is research on how clinicians develop proficiency in this method...
  25. ncbi A meta-analytic review of experiments examining the effects of extrinsic rewards on intrinsic motivation
    E L Deci
    Department of Clinical and Social Sciences in Psychology, University of Rochester, New York 14627, USA
    Psychol Bull 125:627-68; discussion 692-700. 1999
    A meta-analysis of 128 studies examined the effects of extrinsic rewards on intrinsic motivation. As predicted, engagement-contingent, completion-contingent, and performance-contingent rewards significantly undermined free-choice ..
  26. pmc How the brain translates money into force: a neuroimaging study of subliminal motivation
    Mathias Pessiglione
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square London WC1N 3BG, UK
    Science 316:904-6. 2007
    Unconscious motivation in humans is often inferred but rarely demonstrated empirically...
  27. ncbi The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat
    C Martins
    Obesity Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    J Clin Endocrinol Metab 95:1609-16. 2010
    ..An increase in energy intake is likely to result from changes in the appetite control system toward an orexigenic environment; however, few studies have measured how exercise impacts on both orexigenic and anorexigenic peptides...
  28. ncbi Reward-motivated learning: mesolimbic activation precedes memory formation
    R Alison Adcock
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 50:507-17. 2006
    ..The findings are consistent with the hypothesis that reward motivation promotes memory formation via dopamine release in the hippocampus prior to learning.
  29. ncbi The female community health volunteer programme in Nepal: decision makers' perceptions of volunteerism, payment and other incentives
    Claire Glenton
    Department of Global Health and Welfare, SINTEF Society and Technology, P O Box 124 Blindern, Oslo 0314, Norway
    Soc Sci Med 70:1920-7. 2010
    ..have participated in the design and implementation of the Female Community Health Volunteer regarding Volunteer motivation and appropriate incentives, and to compare these views with the views and expectations of Volunteers...
  30. pmc Toward a theory of motivational interviewing
    William R Miller
    Center on Alcoholism, Substance Abuse, and Addictions, MSC11 6280, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Am Psychol 64:527-37. 2009
    ..A resulting causal chain model links therapist training, therapist and client responses during treatment sessions, and posttreatment outcomes...
  31. pmc Using internet and mobile phone technology to deliver an automated physical activity program: randomized controlled trial
    Robert Hurling
    Unilever Corporate Research, Colworth, Bedford, United Kingdom
    J Med Internet Res 9:e7. 2007
    ....
  32. ncbi Motivation, emotion, and their inhibitory control mirrored in brain oscillations
    Gennady G Knyazev
    State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Timakova str, 4, Novosibirsk, 630117, Russia
    Neurosci Biobehav Rev 31:377-95. 2007
    ..This reciprocal relationship may reflect an inhibitory control over motivational and emotional drives which is implemented by the prefrontal cortex...
  33. ncbi Beautiful faces have variable reward value: fMRI and behavioral evidence
    I Aharon
    Motivation and Emotion Neuroscience Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuron 32:537-51. 2001
    ..An extended set of subcortical and paralimbic reward regions also appear to follow aspects of the keypress rather than the rating procedures, suggesting that reward circuitry function does not include aesthetic assessment...
  34. ncbi Lesions of dorsolateral striatum preserve outcome expectancy but disrupt habit formation in instrumental learning
    Henry H Yin
    Department of Psychology, and Brain Research Institute, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095 1563, USA
    Eur J Neurosci 19:181-9. 2004
    ..Furthermore, it suggests that, when the habit system is disrupted, control over instrumental performance reverts to the system controlling the performance of goal-directed instrumental actions...
  35. ncbi A randomized, controlled trial of financial incentives for smoking cessation
    Kevin G Volpp
    Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, USA
    N Engl J Med 360:699-709. 2009
    ....
  36. ncbi Parallel incentive processing: an integrated view of amygdala function
    Bernard W Balleine
    Department of Psychology and the Brain Research Institute, University of California Los Angeles, Box 951563, Los Angeles, CA 90095 1563, USA
    Trends Neurosci 29:272-9. 2006
    ..Given that there is little if any direct behavioral evidence for the serial model, we suggest that more attention should be given to the claims of the parallel view...
  37. ncbi Methodologies for improving response rates in surveys of physicians: a systematic review
    Jonathan B VanGeest
    Kennesaw State University, Georgia, USA
    Eval Health Prof 30:303-21. 2007
    ..Researchers should continue to implement design strategies that have been documented to improve the survey response of physicians...
  38. ncbi Using self-determination theory to promote physical activity and weight control: a randomized controlled trial in women
    Marlene N Silva
    Faculty of Human Kinetics, Technical University of Lisbon, Estrada da Costa, Cruz Quebrada, 1495 688, Lisbon, Portugal
    J Behav Med 33:110-22. 2010
    ..who received either an intervention focused on promoting autonomous forms of exercise regulation and intrinsic motivation, or a general health education program (controls)...
  39. pmc Supply-related drivers of staff motivation for providing intermittent preventive treatment of malaria during pregnancy in Tanzania: evidence from two rural districts
    Godfrey M Mubyazi
    National Institute for Medical Research NIMR, Centre for Enhancement of Effective Malaria Interventions CEEMI, 2338 Ocean Road, P, O Box 9653, Dar es Salaam, Tanzania
    Malar J 11:48. 2012
    ..in the national antenatal care (ANC) system in Tanzania in 2001, little evidence is documented regarding the motivation and performance of health workers (HWs) in the provision of intermittent preventive treatment of malaria during ..
  40. ncbi Neural mechanisms of improvements in social motivation after pivotal response treatment: two case studies
    Avery C Voos
    Yale Child Study Center, Yale University, New Haven, CT, USA
    J Autism Dev Disord 43:1-10. 2013
    ..These results suggest that neural systems supporting social perception are malleable through implementation of PRT...
  41. ncbi Reflective and impulsive determinants of social behavior
    Fritz Strack
    Department of Psychology, University of Wurzburg, Germany
    Pers Soc Psychol Rev 8:220-47. 2004
    ..Extending previous dual-process accounts, this model is not limited to specific domains of mental functioning and attempts to integrate cognitive, motivational, and behavioral mechanisms...
  42. ncbi Office-based motivational interviewing to prevent childhood obesity: a feasibility study
    Robert P Schwartz
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Arch Pediatr Adolesc Med 161:495-501. 2007
    ..To determine whether pediatricians and dietitians can implement an office-based obesity prevention program using motivational interviewing as the primary intervention...
  43. pmc Community participation for malaria elimination in Tafea Province, Vanuatu: Part I. Maintaining motivation for prevention practices in the context of disappearing disease
    Jo An M Atkinson
    Pacific Malaria Initiative Support Centre, Australian Centre for International and Tropical Health, School of Population Health, University of Queensland, Brisbane, Australia
    Malar J 9:93. 2010
    ..In the context of disappearing disease, obtaining and maintaining community participation in strategies to eliminate malaria in the rest of Tafea Province, Vanuatu will be significantly more challenging...
  44. pmc Trait approach and avoidance motivation: lateralized neural activity associated with executive function
    Jeffrey M Spielberg
    Department of Psychology, University of Illinois at Urbana Champaign, Champaign, IL 61820, USA
    Neuroimage 54:661-70. 2011
    b>Motivation and executive function are both necessary for the completion of goal-directed behavior...
  45. ncbi Neural mechanisms associated with food motivation in obese and healthy weight adults
    Laura E Martin
    Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA
    Obesity (Silver Spring) 18:254-60. 2010
    One out of three adults in the United States is clinically obese. Excess food intake is associated with food motivation, which has been found to be higher in obese compared to healthy weight (HW) individuals...
  46. ncbi Encoding predictive reward value in human amygdala and orbitofrontal cortex
    Jay A Gottfried
    Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Science 301:1104-7. 2003
    ..Thus, differential activity in amygdala and orbitofrontal cortex encodes the current value of reward representations accessible to predictive cues...
  47. ncbi The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
    S Ikemoto
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Brain Res Brain Res Rev 31:6-41. 1999
    ..The present conceptual framework may be valuable in understanding the dynamic interplay of NAS DA neurochemistry and behavior, both normal and pathophysiological...
  48. pmc The general and outcome-specific forms of Pavlovian-instrumental transfer are differentially mediated by the nucleus accumbens core and shell
    Laura H Corbit
    School of Psychology, The University of Sydney, Sydney NSW 2006, Australia
    J Neurosci 31:11786-94. 2011
    ....
  49. pmc A randomised control study of a fully automated internet based smoking cessation programme
    L H G Swartz
    Oregon Center for Applied Science, Eugene, OR 97403, USA
    Tob Control 15:7-12. 2006
    ..The objective of this project was to test the short term (90 days) efficacy of an automated behavioural intervention for smoking cessation, the "1-2-3 Smokefree" programme, delivered via an internet website...
  50. ncbi Egalitarianism in young children
    Ernst Fehr
    University of Zurich, Institute for Empirical Research in Economics, Blumlisalpstrasse 10, CH 8006 Zurich, Switzerland
    Nature 454:1079-83. 2008
    ....
  51. ncbi Ego depletion--is it all in your head? implicit theories about willpower affect self-regulation
    Veronika Job
    Stanford University, USA
    Psychol Sci 21:1686-93. 2010
    ..Taken together, the findings suggest that reduced self-control after a depleting task or during demanding periods may reflect people's beliefs about the availability of willpower rather than true resource depletion...
  52. ncbi Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance task
    Katya Rubia
    Department of Child Psychiatry, Institute of Psychiatry, King s College, London, UK
    Neuropharmacology 57:640-52. 2009
    Children with Attention Deficit Hyperactivity Disorder (ADHD) have deficits in motivation and attention that can be ameliorated with the indirect dopamine agonist Methylphenidate (MPH)...
  53. ncbi Understanding participation in sport and physical activity among children and adults: a review of qualitative studies
    Steven Allender
    Public Health, University of Oxford, Rosemary Rue Building, Old Road Campus, Oxford, UK
    Health Educ Res 21:826-35. 2006
    ..Challenges to identity such as having to show others an unfit body, lacking confidence and competence in core skills or appearing overly masculine were barriers to participation...
  54. ncbi Dopamine, learning and motivation
    Roy A Wise
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Neurosci 5:483-94. 2004
  55. ncbi The unconscious will: how the pursuit of goals operates outside of conscious awareness
    Ruud Custers
    Department of Psychology, Utrecht University, Heidelberglaan 1, 3584 CS Utrecht, Netherlands
    Science 329:47-50. 2010
    ..Here we analyze how goal pursuit can possibly operate unconsciously...
  56. pmc Effects of voucher-based incentives on abstinence from cigarette smoking and fetal growth among pregnant women
    Sarah H Heil
    Departments of Psychiatry, University of Vermont, Burlington, VT 05401, USA
    Addiction 103:1009-18. 2008
    ..This study examined whether voucher-based reinforcement therapy (VBRT) contingent upon smoking abstinence during pregnancy is an effective method for decreasing maternal smoking during pregnancy and improving fetal growth...
  57. ncbi Measuring adaptations of motivational interviewing: the development and validation of the behavior change counseling index (BECCI)
    Claire Lane
    Communication Skills Unit, Department of General Practice, University of Wales College of Medicine, Llanedeyrn Health Center, Cardiff CF23 9PN, UK
    Patient Educ Couns 56:166-73. 2005
    ..BECCI will also provide valuable information about the standard of BCC that practitioners were trained to deliver in studies of BCC as an intervention...
  58. ncbi Employment preferences of public sector nurses in Malawi: results from a discrete choice experiment
    Lindsay J Mangham
    Health Economics and Financing Programme, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 13:1433-41. 2008
    ..To understand the employment preferences of Malawian public sector registered nurses, and to ascertain whether salary increases significantly affect how nurses regard their employment...
  59. ncbi Motivational interviewing in health settings: a review
    Eileen Britt
    Department of Psychology, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Patient Educ Couns 53:147-55. 2004
    ..The current paper provides an overview of MI, with particular reference to its application to health problems...
  60. pmc The addicted human brain: insights from imaging studies
    Nora D Volkow
    Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Clin Invest 111:1444-51. 2003
  61. ncbi NOvelty-related motivation of anticipation and exploration by dopamine (NOMAD): implications for healthy aging
    Emrah Duzel
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, 17 Queen Square, London WC1N 3AR, UK
    Neurosci Biobehav Rev 34:660-9. 2010
    ..We propose a framework called 'NOvelty-related Motivation of Anticipation and exploration by Dopamine' (NOMAD) which captures existing links between novelty, dopamine, ..
  62. ncbi A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention
    Ana Cubillo
    Department of Child Psychiatry, Institute of Psychiatry, King s College London, UK
    Cortex 48:194-215. 2012
    ..that support the notion of a persistence of neurofunctional deficits in adults with ADHD during attention and motivation functions...
  63. ncbi Neurobiology of the structure of personality: dopamine, facilitation of incentive motivation, and extraversion
    R A Depue
    Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA
    Behav Brain Sci 22:491-517; discussion 518-69. 1999
    ..Positive affect (a combination of positive feelings and motivation) is closely associated with extraversion. Extraversion is accordingly based on positive incentive motivation...
  64. ncbi Motivation and cognitive control in the human prefrontal cortex
    Frederique Kouneiher
    Institut National de la Sante et de la Recherche Medicale, Center for Neuroimaging Research, Universite Pierre et Marie Curie, Ecole Normale Superieure, Paris, France
    Nat Neurosci 12:939-45. 2009
    ..Little is known, however, about how the PFC combines motivation and the selection processes underlying cognitive control...
  65. ncbi A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRI
    Brian Knutson
    Department of Psychology, Building 420, Jordan Hall, Stanford University, Stanford, CA 94305 2130, USA
    Neuroimage 18:263-72. 2003
    ..00 win, MPFC activity decreased, relative to outcomes with no incentive value. These findings suggest that in the context of processing monetary rewards, a region of the MPFC preferentially tracks rewarding outcomes...
  66. ncbi Automatic and controlled processes and the development of addictive behaviors in adolescents: a review and a model
    Reinout W Wiers
    Experimental Psychology, Maastricht University, Maastricht, The Netherlands
    Pharmacol Biochem Behav 86:263-83. 2007
    ..Self-regulation critically depends on two factors: ability and motivation to regulate the appetitive response tendency...
  67. ncbi Reward anticipation and outcomes in adult males with attention-deficit/hyperactivity disorder
    Andreas Strohle
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Schumannstr 20 21, 10117 Berlin, Germany
    Neuroimage 39:966-72. 2008
    ..These findings suggest that male adults with ADHD show neural signs of abnormal reward processing. Future studies will have to investigate whether these dysfunctional patterns might be normalized by treatment...
  68. ncbi Motivation, money and respect: a mixed-method study of Tanzanian non-physician clinicians
    Clare I R Chandler
    London School of Hygiene and Tropical Medicine, Infectious and Tropical Diseases, Keppel Street, London WC1E 7HT, UK
    Soc Sci Med 68:2078-88. 2009
    Poor quality of care is a major concern in low-income countries, and is in part attributed to low motivation of healthcare workers...
  69. ncbi Have motivation theories guided the development and reform of medical education curricula? A review of the literature
    Rashmi A Kusurkar
    Center for Research and Development of Education, University Medical Center Utrecht, Utrecht, The Netherlands
    Acad Med 87:735-43. 2012
    ..The authors explored whether student motivation has guided medical education curriculum developments.
  70. pmc Financial incentive-based approaches for weight loss: a randomized trial
    Kevin G Volpp
    Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    JAMA 300:2631-7. 2008
    ..Identifying effective obesity treatment is both a clinical challenge and a public health priority due to the health consequences of obesity...
  71. ncbi Predictive validity of the Motivation To Stop Scale (MTSS): a single-item measure of motivation to stop smoking
    D Kotz
    Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands
    Drug Alcohol Depend 128:15-9. 2013
    Many different measures of motivation to stop smoking exist but it would be desirable to have a brief version that is standard for use in population surveys and for evaluations of interventions to promote cessation...
  72. pmc Affective neuroscience of pleasure: reward in humans and animals
    Kent C Berridge
    Department of Psychology, University of Michigan, Ann Arbor, MI, USA
    Psychopharmacology (Berl) 199:457-80. 2008
    ..Pleasure and reward are generated by brain circuits that are largely shared between humans and other animals...
  73. ncbi Systematic review of the use of financial incentives in treatments for obesity and overweight
    V Paul-Ebhohimhen
    University of Aberdeen, Health Services Research Unit, Aberdeen, UK
    Obes Rev 9:355-67. 2008
    ....
  74. ncbi Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders
    Amy F T Arnsten
    Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, CT 06510, USA
    J Am Acad Child Adolesc Psychiatry 51:356-67. 2012
    ....
  75. ncbi Orbitofrontal cortex and its contribution to decision-making
    Jonathan D Wallis
    Helen Wills Neuroscience Institute and the Department of Psychology, University of California, Berkeley, California 94720 3190, USA
    Annu Rev Neurosci 30:31-56. 2007
    ..Thus, acting together, these prefrontal areas can ensure that our behavior is most efficiently directed towards satisfying our needs...
  76. ncbi Satisfaction, motivation, and intent to stay among Ugandan physicians: a survey from 18 national hospitals
    Sam Luboga
    School of Medicine, Makerere University, Kampala, Uganda
    Int J Health Plann Manage 26:2-17. 2011
    ..We report what could entice physicians to stay longer, satisfaction with current positions, and future career intentions...
  77. ncbi Motivation as an independent and a dependent variable in medical education: a review of the literature
    R A Kusurkar
    Center for Research and Development of Education, University Medical Center Utrecht, The Netherlands
    Med Teach 33:e242-62. 2011
    b>Motivation in learning behaviour and education is well-researched in general education, but less in medical education.
  78. ncbi A self-determination approach to the understanding of motivation in physical education
    N Ntoumanis
    Leeds Metropolitan University, UK
    Br J Educ Psychol 71:225-42. 2001
    ..However, these initiatives will have limited success if students are not motivated to participate actively in their PE lessons...
  79. pmc Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling
    Kate M Wassum
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California 90024, USA
    Learn Mem 18:475-83. 2011
    ..5 mg/kg i.p.) on Pavlovian incentive motivation and found that flupenthixol blocked the ability of a conditioned stimulus to enhance both goal approach and ..
  80. ncbi Vaginal practices as women's agency in sub-Saharan Africa: a synthesis of meaning and motivation through meta-ethnography
    Adriane Martin Hilber
    University of Bern, Institute of Social and Preventive Medicine, Finkenhubelweg 11, CH 3012 Bern, Switzerland Swiss Tropical and Public Health Institute, Switzerland
    Soc Sci Med 74:1311-23. 2012
    ..The success of new female-controlled prevention technologies, such as microbicides, might be determined by whether they can and will be used by women in the course of their daily life...
  81. ncbi Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress
    Brian A Baldo
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, Wisconsin 53719, USA
    J Comp Neurol 464:220-37. 2003
    ....
  82. ncbi Reward and motivation systems: a brain mapping study of early-stage intense romantic love in Chinese participants
    Xiaomeng Xu
    Department of Psychology, Stony Brook University, Stony Brook, New York 11794 2500, USA
    Hum Brain Mapp 32:249-57. 2011
    ..2007]: J Cogn Neurosci 19:1218–1230), revealing activation in the reward and motivation systems of the brain...
  83. ncbi Supporting autonomy to motivate patients with diabetes for glucose control
    G C Williams
    Department of Medicine, The Genesee Hospital, The University of Rochester, New York 14627, USA
    Diabetes Care 21:1644-51. 1998
    We applied the self-determination theory of human motivation to examine whether patient perceptions of autonomy supportiveness (i.e...
  84. ncbi The psychology and neurobiology of addiction: an incentive-sensitization view
    T E Robinson
    Department of Psychology Biopsychology Program, University of Michigan, Ann Arbor 48109, USA
    Addiction 95:S91-117. 2000
    ..2) The brain systems that are changed include those normally involved in the process of incentive motivation and reward...
  85. ncbi Neuronal activity related to reward value and motivation in primate frontal cortex
    Matthew R Roesch
    Center for the Neural Basis of Cognition, Mellon Institute, Room 115, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Science 304:307-10. 2004
    ..The activity of these neurons might be related to the value of the expected reward or to the degree of motivation induced by expectation of the reward...
  86. pmc Neurogenetics and pharmacology of learning, motivation, and cognition
    Michael J Frank
    Department of Cognitive, Linguistic and Psychological Sciences, Brown Institute for Brain Science, Brown University, Providence, RI 02912 1978, USA
    Neuropsychopharmacology 36:133-52. 2011
    Many of the individual differences in cognition, motivation, and learning-and the disruption of these processes in neurological conditions-are influenced by genetic factors...
  87. ncbi Changing AIDS risk behavior: effects of an intervention emphasizing AIDS risk reduction information, motivation, and behavioral skills in a college student population
    J D Fisher
    Department of Psychology, University of Connecticut, Storrs 06269 1020, USA
    Health Psychol 15:114-23. 1996
    This research used the Information-Motivation-Behavioral Skills (IMB) model of AIDS risk behavior change (J. D. Fisher & Fisher, 1992a) to reduce AIDS risk behavior in a college student population...
  88. ncbi Physical activity preferences, preferred sources of assistance, and perceived barriers to increased activity among physically inactive Australians
    M L Booth
    Department of Public Health and Community Medicine, University of Sydney, New South Wales, Australia
    Prev Med 26:131-7. 1997
    ..Efforts to decrease the population prevalence of inactivity will have a greater impact if they are tailored to the needs and preferences of the community...
  89. ncbi Ten things that motivational interviewing is not
    William R Miller
    Department of Psychology, University of New Mexico, Logan Hall, Albuquerque, New Mexico NM 87131 1161, USA
    Behav Cogn Psychother 37:129-40. 2009
    ..In the 26 years since it was first introduced in this journal, motivational interviewing (MI) has become confused with various other ideas and approaches, owing in part to its rapid international diffusion...
  90. pmc Individual differences in the attribution of incentive salience to reward-related cues: Implications for addiction
    Shelly B Flagel
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Neuropharmacology 56:139-48. 2009
    ..It will be important, therefore, to study how environmental, neurobiological and genetic interactions determine the extent to which individuals attribute incentive value to reward-predictive stimuli...
  91. pmc Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors
    Estefanía P Bello
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Neurosci 14:1033-8. 2011
    ..The mice also exhibited increased place preference for cocaine and enhanced motivation for food reward...
  92. ncbi The neural basis of addiction: a pathology of motivation and choice
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB 403, Charleston, SC 29425, USA
    Am J Psychiatry 162:1403-13. 2005
    ....
  93. ncbi Altruistic helping in human infants and young chimpanzees
    Felix Warneken
    Department of Developmental and Comparative Psychology, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Science 311:1301-3. 2006
    ..This requires both an understanding of others' goals and an altruistic motivation to help. In addition, we demonstrate similar though less robust skills and motivations in three young chimpanzees...
  94. pmc "Catastrophic" pathways to smoking cessation: findings from national survey
    Robert West
    University College London, London WC1E 6BT
    BMJ 332:458-60. 2006
    ..To assess the extent to which the prevailing model of smoking cessation (that smokers typically prepare their attempts to stop smoking in advance and that doing so increases their chances of success) is correct...
  95. pmc Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers
    Stephanie L Borgland
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94110, USA
    J Neurosci 29:11215-25. 2009
    ..Here, we show that orexin/hypocretin receptor-1 (ox/hcrt-1R) signaling is important for motivation for highly salient, positive reinforcement...
  96. pmc Human pavlovian-instrumental transfer
    Deborah Talmi
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, WC1N 3BG London, United Kingdom
    J Neurosci 28:360-8. 2008
    ..Furthermore, using functional magnetic resonance imaging, we show that this enhanced motivation was associated with a trial-by-trial correlation with the blood oxygenation level-dependent (BOLD) signal in the ..
  97. ncbi The development of computer-generated tailored interventions
    A Dijkstra
    Department of Clinical and Health Psychology, Leiden University, P O Box 9555, 2300 RB, Leiden, Netherlands
    Patient Educ Couns 36:193-203. 1999
    ..This methodology may result in largely different tailored interventions depending on the theoretical framework used, the adaptation of the messages and the inclusion of feedback...
  98. ncbi Task-related default mode network modulation and inhibitory control in ADHD: effects of motivation and methylphenidate
    Elizabeth B Liddle
    University of Nottingham, Nottingham, UK
    J Child Psychol Psychiatry 52:761-71. 2011
    ..We also hypothesised that methylphenidate, an indirect dopamine agonist, would tend to normalise abnormal patterns of DMN deactivation...
  99. ncbi Motivational interviewing in health care settings. Opportunities and limitations
    K M Emmons
    Dana Farber Cancer Institute, Department of Adult Oncology, Harvard School of Public Health, Department of Health and Social Behavior Boston, Massachusetts 02115, USA
    Am J Prev Med 20:68-74. 2001
    ..This paper provides an overview of important issues to consider in adapting an effective counseling strategy to new settings, and is intended to begin a dialogue about the use of MI in community health care settings...
  100. ncbi Ghrelin directly targets the ventral tegmental area to increase food motivation
    K P Skibicka
    Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 11, PO Box 434, SE 40530 Gothenburg, Sweden
    Neuroscience 180:129-37. 2011
    ..we sought to determine if ghrelin acts directly within these mesolimbic reward areas to increase food reward/motivation in studies that combine feeding behavior, pharmacology, and neuroanatomy...
  101. ncbi Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning
    Ann E Kelley
    Department of Psychiatry and Neuroscience Program, University of Wisconsin Madison Medical School, 6001 Research Park Boulevard, Madison, WI 53719, USA
    Neurosci Biobehav Rev 27:765-76. 2004
    ..the role of the nucleus accumbens in food motivation, and (ii). its putative functions in cellular plasticity underlying appetitive learning...

Research Grants75

  1. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  2. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  3. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..While the primary motivation for this proposal is to improve the treatment of schizophrenia, the resulting findings will contribute to our ..
  4. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    ..I am pursuing a career path to become an NIH-funded independent investigator and I already possess the motivation and expertise to independently carry out specific aims 1 and 4...
  5. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..My personal motivation for this study is that I have a grandmother who had suffered severe arrhythmia and then died last year...
  6. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..My personal motivation for this study is that I have a grandmother who had suffered severe arrhythmia and then died last year...
  7. Sex Steroid Hormone Regulation of Drug Reinforcement
    Diane Lebesgue; Fiscal Year: 2012
    ..reinforcement as measured by facilitation of the acquisition of cocaine self administration and to increase motivation to take cocaine under a progressive ratio schedule...
  8. Functional Neuroimaging of Individual Differences in Affect and Motivation
    BRIAN JAMES MICKEY; Fiscal Year: 2013
    ..At the same time, the project will address important, testable questions about the neurobiology of genetic vulnerability to MDD, an identified public health priority. ..
  9. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..The broad motivation for this line of research is the relentless worldwide increase in antibiotic resistance amongst pathogenic ..
  10. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2013
    ..we will compare the involvement of each system in regulating responses to olfactory cues that control sexual motivation and reward...
  11. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..ET) to treat the symptoms associated with low levels or a lack of estrogens, including decreased sexual motivation, hot flushes, sleep disorders, depression/anxiety, brain and spinal cord trauma, amyotrophic lateral sclerosis, ..
  12. Histone Methylation: a role in excessive ethanol intake and self-administration
    Jennifer A Rinker; Fiscal Year: 2012
    ..we predict that regional overexpression or suppression of G9a in the NAc will correspondingly alter the motivation to respond for ethanol reinforcers in an operant self-administration paradigm (Specific Aim 3)...
  13. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..effects of marijuana and are a critical component of the endogenous cannabinoid system, which is involved in motivation and reward, motor control, appetite, learning and memory, and pain and thermoregulation...
  14. Inducible recombination and gene expression in specific neurotransmitter systems
    Steven A Thomas; Fiscal Year: 2012
    ..understanding of fundamental neurophysiological and behavioral processes such as sleep, arousal and attention, motivation and reward, and learning and memory, as well as disorders related to these processes that include narcolepsy, ..
  15. Neural Representation of Reach-to-Grasp for Cortical FES Neuroprostheses
    Abidemi Bolu Ajiboye; Fiscal Year: 2012
    ..This is the overarching motivation for the research described i this proposal...
  16. Monoamine Contributions to Neurocircuitry in Eating Disorders
    Walter H Kaye; Fiscal Year: 2013
    ..response to sucrose may have the most diminished striatal DA concentrations, and presumably less motivation to eat...
  17. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2012
    ..Basal ganglia DA plays a pivotal role in regulating multiple behaviors including mood, motivation/reward, motor activity, sleep and cognition...
  18. Appetite-regulating Hormones and Neurocircuitry in Anorexia Nervosa
    ELIZABETH AUSTEN LAWSON; Fiscal Year: 2013
    ..that the AN phenotype is characterized by abnormalities in hormones and neurocircuitry involved in food motivation and reward, and that T administration improves outcomes by modulating these pathways...
  19. Self-Determination Theory and Lifestyle Behaviors in Barrett's Esophagus Patients
    HODA J BADR; Fiscal Year: 2010
    ..Autonomous motivation (i.e., behaving congruently with one's values) facilitates behavior change;controlled motivation (i.e...
  20. Cholinergic Receptors as Targets for Accelerated Anthelmintic Discovery
    MICHAEL JOHN KIMBER; Fiscal Year: 2013
    ..the problem is the reticence of the pharmaceutical industry to engage this need for NTD drugs without the motivation of a financial incentive...
  21. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    DIANNE FIGLEWICZ LATTEMANN; Fiscal Year: 2013
    ..and affordability of palatable, high caloric density foods;activation of responsive CNS pathways that mediate motivation and reward;and loss of effectiveness of endocrine adiposity signals to act at the CNS, may all contribute to ..
  22. Intra-operative confocal imaging to guide Mohs surgery
    Milind Rajadhyaksha; Fiscal Year: 2012
    ..The motivation is to create a relatively simple, small and low-cost confocal microscope for real-time imaging in reflectance, ..
  23. Motivational Incentives to Reduce Secondhand Smoke in NICU Infants'Homes
    Angela L Stotts; Fiscal Year: 2013
    ..The effects of MI+ versus CC on household smoking and infant smoke exposure are expected to be mediated via motivation to change and treatment participation...
  24. How do Amine Neurons Work?
    Edward A Kravitz; Fiscal Year: 2013
    ..amines have been shown to be intimately involved in many essential aspects of behavior in fruit flies, including motivation and reward, locomotion and feeding, learning and memory, and courtship and aggression...
  25. Anabolic-androgenic steroids enhance motivation
    Ruth I Wood; Fiscal Year: 2013
    ..Understanding behavioral effects of AAS use in humans is complicated by the user's motivation for increased strength and muscle mass...
  26. Bioconductor: an open computing resource for genomics
    Martin Morgan; Fiscal Year: 2010
    ..The PI should articulate the strategic goals, as well as their research motivation and translate that into an action plan...
  27. Multigenerational Epigenetic Effects of Cannabis Exposure
    Yasmin L Hurd; Fiscal Year: 2013
    ..adolescent exposure to D-tetrahydrocannabinol (THC;primary psychoactive component of cannabis) exhibit reduced motivation and a depression-like phenotype, as well as anxiety-related behaviors that develop in response to their tendency ..
  28. Environmental Triggers of Cardiometabolic Disease
    Sanjay Rajagopalan; Fiscal Year: 2013
    ..Our broader motivation is to create a framework to investigate the role of environmental factors in conferring risk susceptibility for ..
  29. Treatment Implications of Trauma Memory Modulation for PTSD & Alcohol Dependence
    Michael E Saladin; Fiscal Year: 2010
    ..of the PTSD and AD interrelationship is that effective treatment of PTSD should yield significant reductions in motivation to drink and drinking behavior...
  30. CRF and Stress Modulation of Phasic Dopamine Release and Behavior
    MATTHEW J WANAT; Fiscal Year: 2013
    ..cells of the ventral tegmental area (VTA) are well situated to mediate the interaction between stress and motivation, but to date this has not been directly tested...
  31. Development of a Human Hydrolase to Treat Cocaine Abuse and Overdose: Rat Models
    WILLIAM STEPHEN BRIMIJOIN; Fiscal Year: 2011
    ..SECOND are tests of CocH on the motivation for cocaine self-administration in rats working under a progressive ratio schedule for several doses of drug...
  32. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen A McClung; Fiscal Year: 2013
    ..This could lead to an anticipatory effect with increased craving and motivation to take drugs at a specific time of day...
  33. Melanocortin Signaling in Depression
    Michael Lutter; Fiscal Year: 2013
    The long term goal of this proposal is to investigate the regulation of mood and motivation by hypothalamic feeding systems...
  34. Workplace Wellness Initiatives to Combat Obesity
    JASON PERRY BLOCK; Fiscal Year: 2013
    ..The need for novel interventions to address the obesity epidemic in the US is the motivation for the Aims of Dr. Block's K23 proposal...
  35. Phase 2 Study of rAAV1-CB-hAAT for Treatment of Alpha-1 Antitrypsin Deficiency
    Jeffrey D Chulay; Fiscal Year: 2013
    ..The current therapy is in short supply, resulting in low physician motivation to accurately diagnose the vast majority of patients, since not all of the minority of patients who are ..
  36. Reducing Weight and Diabetes Risk in an Underserved Population
    Carla A Green; Fiscal Year: 2012
    ..A fourth aim explores effects of motivation, social support, and outcomes expectancies on primary outcomes, and moderators of intervention effectiveness (..
  37. Regulation of Brain Signaling After Bariatric Surgery
    Jonathan Q Purnell; Fiscal Year: 2010
    ..stimuli have consistently demonstrated involvement of dopaminergic pathways traditionally linked with reward motivation. With the discovery of leptin receptors within these pathways, a more integrated model of central nervous system ..
  38. Regulation of striatal cannabinoid CB1 receptors by DARPP32 and deltaFosB mediate
    Matthew F Lazenka; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Marijuana and cannabinoid drugs modulate the function of brain regions that control motivation and motor activity...
  39. Translational Research on Addiction to Palatable Food
    Nicole M Avena; Fiscal Year: 2013
    ..data and the findings of others support the theory that overeating of palatable food might produce an extreme motivation that resembles a dependency on certain foods, possibly fueling the urge to overeat and subsequent obesity in ..
  40. Ontogenic factors in adolescent-emergent depression and decision-making
    SHANNON LEIGH GOURLEY; Fiscal Year: 2013
    ..reward sensitivity, disrupts decision-making processes essential to accomplishing goals, and diminishes motivation to perform even everyday tasks, we will, as a last aim, use viral-mediated gene silencing and modified surgical ..
  41. Exercise and H2S mitigate homocysteine-mediated beta2-adrenergic receptor dysfunc
    Paras Kumar Mishra; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Specific Aims: Lack of motivation to exercise is the hallmark of obesity and type2 diabetes (T2D)...
  42. Liquid Crystal-Based End-of-Service-Life-Indicator for Toluene Vapor
    BHARAT R ACHARYA; Fiscal Year: 2011
    ..The motivation for the development of the new technology is two-fold: First, the high cost, requirement for power, and large ..
  43. Motivational Interviewing and Physical Activity Behavior Change in Arthritis
    Linda Ehrlich-Jones; Fiscal Year: 2012
    ..provided by applicant): I have been intrigued with the adaptability of people with arthritis, and how their motivation to strive for independence influences their ability to manage their disease. In 2005, Dr...
  44. Cytokine Effects on Amphetamine-Induced Dopamine Release using PET Neuroimaging
    Jennifer C Felger; Fiscal Year: 2011
    ..Basal ganglia DA plays a pivotal role in regulating behaviors including mood, motor activity, motivation and reward, and mounting evidence indicates that the DA system may be targeted by innate immune cytokines...
  45. Addressing Oral Health Disparities in Individuals with Mental Health Problems
    Lisa J Heaton; Fiscal Year: 2013
    ..Indirectly, mood and anxiety disorders can interfere with motivation for adequate oral hygiene and willingness to seek preventive dental treatment...
  46. Enhancing cancer outreach for low-income adults with innovative smoking cessation
    Damon J Vidrine; Fiscal Year: 2013
    ..counseling sessions and a cell phone-delivered text/graphical messaging component;2) Evaluate the role of quit motivation, nicotine withdrawal, risk perception, self- efficacy, social support, and negative affect as potential ..
  47. Transgenic Mitomice Models for Treatment of Blinding Diseases
    John Guy; Fiscal Year: 2013
    ..Our motivation in pursuing this project is to develop gene therapy for untreatable mitochondrial diseases that lead to ..
  48. HIV Prevention Intervention for Young Transgender Women
    MATTHEW JAMES MIMIAGA; Fiscal Year: 2013
    ..transgender adaptation and integration, collective self-esteem/empowerment, information (HIV knowledge), motivation (attitudes, norms, and intentions for safer sex), and behavioral skills (discussing sex and condom use with ..
  49. Mechanisms of COPD Subphenotype Development
    MICHAEL BRADLEY DRUMMOND; Fiscal Year: 2013
    ..Early in his career, he has demonstrated motivation and productivity in his ongoing research endeavors...
  50. RENAL FUNCTION AND DISEASE
    Bruce A Stanton; Fiscal Year: 2013
    ..Predoctoral trainees are chosen on the basis of their motivation for a long-term career, prior research experience and training, references, and academic standing...
  51. Evaluation of Cardiovascular Outcomes Among Childhood Cancer Survivors
    Melissa M Hudson; Fiscal Year: 2012
    ..techniques tailored to survivors'baseline measures of knowledge, beliefs, readiness for follow-up, motivation, self-efficacy, affect, fear, and survivor-provider interaction...
  52. Extinction is mediated by the infralimbic cortex and protein kinase C epsilon
    Philip M Newton; Fiscal Year: 2010
    ..This brain region controls motivation and drive, as well as facilitating the ability to forget learned associations (for example, fearful memories or ..
  53. IVR Technology to Mobilize Contingency Management for Smoking Cessation
    SHEILA MARIE ALESSI; Fiscal Year: 2012
    ..Nicotine withdrawal, motivation to change, urges to smoke, and substance/medication use will be assessed at Intake, Week 4 (end of counseling ..
  54. Validation of MRI Microvascular Biomarkers in Pancreatic Cancer with Magnetic Nan
    ALEXANDER RAMOS GUIMARAES; Fiscal Year: 2013
    ..I have the expertise, leadership and motivation necessary to successfully carry out the proposed work...
  55. The role of taste in amino acid appetite
    Ivan E de Araujo; Fiscal Year: 2013
    ..proposed project will provide novel data on how the metabolic and brain reward circuitry leads to the powerful motivation to consume sweet-tasting foods...
  56. Electromechanical reshaping of tissue
    Brian Wong; Fiscal Year: 2010
    ..technologies, efficacy must be demonstrated in an animal model to fuel clinical interest and provide justifiable motivation to pursue more extensive basic studies focusing on both mechanisms and optimization...
  57. Neural mechanisms underlying abnormal food reward processing in depressed women
    LAURA MCGRATH HOLSEN; Fiscal Year: 2013
    ..develop a knowledge base in the neuroendocrine system, integral to the study of mood disorders and abnormal food motivation, c) obtain expert training in advanced modeling of fMRI data, d) enhance her understanding of critical hormone ..
  58. Alpha-Synuclein-Metal Complexes and Oxidative Stress in Parkinson's Disease
    Feimeng Zhou; Fiscal Year: 2012
    ..g., dopamine, glutathione, and ascorbic acid) in the development of oxidative stress and damage. The motivation behind the proposed study is that the inconsistencies in the current oxidative stress hypothesis stem largely ..
  59. Glucocorticoids, Bone Strength and Angiogenesis
    ROBERT STEWART WEINSTEIN; Fiscal Year: 2013
    ..osteoporosis and investigation of the reasons for the limited response to current therapy would increase motivation to protect the skeleton as early as possible, before there are decreases in bone density...
  60. Ethanol Dependence and Kappa Receptor Antagonists
    MARC REZA AZAR; Fiscal Year: 2011
    ..Alcoholism is a chronic relapsing disorder characterized by multiple stages and multiple sources of motivation for excessive intake of the drug (i.e., the addiction cycle)...
  61. The impact of genetic testing for type 2 diabetes on health behaviors
    William S Yancy; Fiscal Year: 2013
    ..Therefore, it is imperative to intervene earlier and to find new ways to increase motivation to initiate and maintain lifestyle changes...
  62. Preventive Web-Based Intervention for Spouses of Traumatized Military Personnel
    BENTSON H contact MCFARLAND; Fiscal Year: 2010
    ..The motivation for the project is unchanged in that spouses of military personnel returned from Iraq or Afghanistan must often ..
  63. Using Ecolog. Momentary Assess. To Examine Pain & Smoking In Head & Neck Cancer P
    CHO YAN LAM; Fiscal Year: 2010
    ..Therefore, it is important for researchers to study the mechanisms that underlie smoking motivation and abstinence failure in cancer patients...
  64. Obesity Education Campaign - a multimedia resource for parents and significant ca
    HENRY WATTS; Fiscal Year: 2009
    ..for parents and significant caregivers of children ages 3-5 that addresses this need by building knowledge, motivation, self-efficacy, and parenting and self- management skills around implementing a family-centered plan for ..
  65. Ecdysone modulation of sexual behavior in Drosophila melanogaster
    GEOFFREY GANTER; Fiscal Year: 2009
    ..These results suggest that ecdysone signaling in the adult male is necessary for modulation of sexual motivation, and that sexual behavior is plastic in the adult male fly, neither finding having been shown before...
  66. Effects of Clopazine and haloperidol on responding
    Danielle Gulick; Fiscal Year: 2010
    ..The hamster consumes alcohol steadily in free access conditions, but the hamster's preference and motivation for alcohol have not been tested...
  67. Cocaine disruption of maternal motivation: preference for pups vs. cocaine
    MARIANA PEREIRA ARBOLEYA; Fiscal Year: 2010
    ..In some females, cocaine is reinforcing enough to compete with maternal motivation for pups, whereas in others maternal motivation is the stronger, more resilient force...
  68. Family Planning & Preconception HIV testing
    LINDA E HOCK LONG; Fiscal Year: 2010
    ..adapt the health care provider delivered Options risk reduction intervention, which is based on the Information-Motivation- Behavioral Skills model of HIV prevention and uses Motivational Interviewing techniques to deliver risk ..
  69. Healthy Teens TXT ME; IT to change teen health risk behaviors
    Ardis L Olson; Fiscal Year: 2010
    ..After the health visits clinicians are not able to offer supports to transform motivation to change a health behavior into better outcomes for adolescents...
  70. INTEGRATION OF CHEMOSENSORY AND HORMONAL STIMULI
    Ruth Wood; Fiscal Year: 2006
    ..Castration also reduces sexual motivation, as measured by interest in vaginal odors and preference for a receptive female...
  71. Anticipating reward & threat: A test of biobehavioral processes in MDD vs anxiety
    STEWART AARON SHANKMAN; Fiscal Year: 2010
    ..An important question, though, is whether low approach motivation is specific to depression and/or whether hyper-sensitivity to threat/aversiveness is specific to anxiety...
  72. SEROTONIN Treatment of Cocaine Dependence
    ERIC STRAIN; Fiscal Year: 2005
    ..sizes, heterogeneous study populations, failure to ensure compliance in taking medication, inadequate patient motivation)...
  73. ETHANOL AND AMNESIC DRUGS IN P AND NP RATS
    GALEN WENGER; Fiscal Year: 2000
    ..Prior to the initiation of these tests of cognitive function, the degree of motivation of the P and NP rats to lever press for initiation of these tests of cognitive function, the degree of ..
  74. STUDENT OPPORTUNITIES IN APPLIED RESEARCH (SOAR)
    TERESA MORISHITA; Fiscal Year: 2003
    ..The motivation for the SOAR program lies in a need within the biomedical research community to recruit more veterinarians, ..
  75. DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PD
    Marjan Jahanshahi; Fiscal Year: 2005
    ..number generation) and learning (conditional associative learning, motor sequence learning) and on mood and motivation using a series of clinical neuropsychological and PET activation studies. The specific aims are: 1...