Summary: Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Top Publications

  1. ncbi A new approach on stress-related depression & anxiety: Neuro-Psycho- Physical-Optimization with Radio Electric Asymmetric-Conveyer
    Salvatore Rinaldi
    Rinaldi Fontani Institute, Florence, Italy
    Indian J Med Res 132:189-94. 2010
  2. pmc Computer therapy for the anxiety and depressive disorders is effective, acceptable and practical health care: a meta-analysis
    Gavin Andrews
    School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 5:e13196. 2010
  3. pmc Adherence in internet interventions for anxiety and depression
    Helen Christensen
    Centre for Mental Health Research, Australian National University, Canberra ACT 0200, Australia
    J Med Internet Res 11:e13. 2009
  4. ncbi Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
    F Tronche
    Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Genet 23:99-103. 1999
  5. ncbi Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
    S Pellow
    J Neurosci Methods 14:149-67. 1985
  6. ncbi Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study
    Yair Bar-Haim
    Adler Center for Reasearch in Child Development and Psychopathology, Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Psychol Bull 133:1-24. 2007
  7. ncbi Collaborative care for depression and anxiety problems
    Janine Archer
    School of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK
    Cochrane Database Syst Rev 10:CD006525. 2012
  8. pmc Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
    Denis J David
    Université Paris Sud EA 3544, Faculte de Pharmacie, Chatenay Malabry Cedex F 92296, France
    Neuron 62:479-93. 2009
  9. ncbi Anxiety and cognitive performance: attentional control theory
    Michael W Eysenck
    Department of Psychology, Royal Holloway University of London, London, United Kingdom
    Emotion 7:336-53. 2007
  10. ncbi Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence
    M R DiMatteo
    Department of Psychology, University of California, Riverside, CA 92521, USA
    Arch Intern Med 160:2101-7. 2000

Detail Information

Publications281 found, 100 shown here

  1. ncbi A new approach on stress-related depression & anxiety: Neuro-Psycho- Physical-Optimization with Radio Electric Asymmetric-Conveyer
    Salvatore Rinaldi
    Rinaldi Fontani Institute, Florence, Italy
    Indian J Med Res 132:189-94. 2010
  2. pmc Computer therapy for the anxiety and depressive disorders is effective, acceptable and practical health care: a meta-analysis
    Gavin Andrews
    School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 5:e13196. 2010
    Depression and anxiety disorders are common and treatable with cognitive behavior therapy (CBT), but access to this therapy is limited.
  3. pmc Adherence in internet interventions for anxiety and depression
    Helen Christensen
    Centre for Mental Health Research, Australian National University, Canberra ACT 0200, Australia
    J Med Internet Res 11:e13. 2009
    Open access websites which deliver cognitive and behavioral interventions for anxiety and depression are characterised by poor adherence...
  4. ncbi Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
    F Tronche
    Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Genet 23:99-103. 1999
    ..Conditional mutagenesis of Gr in the nervous system provides genetic evidence for the importance of Gr signalling in emotional behaviour because mutant animals show an impaired behavioural response to stress and display reduced anxiety.
  5. ncbi Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
    S Pellow
    J Neurosci Methods 14:149-67. 1985
    ..Confinement to the open arms was associated with the observation of significantly more anxiety-related behaviours, and of significantly greater plasma corticosterone concentrations, than confinement to the ..
  6. ncbi Threat-related attentional bias in anxious and nonanxious individuals: a meta-analytic study
    Yair Bar-Haim
    Adler Center for Reasearch in Child Development and Psychopathology, Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Psychol Bull 133:1-24. 2007
    ..N = 2,263 anxious,N = 1,768 nonanxious) examined the boundary conditions of threat-related attentional biases in anxiety. Overall, the results show that the bias is reliably demonstrated with different experimental paradigms and under ..
  7. ncbi Collaborative care for depression and anxiety problems
    Janine Archer
    School of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK
    Cochrane Database Syst Rev 10:CD006525. 2012
    Common mental health problems, such as depression and anxiety, are estimated to affect up to 15% of the UK population at any one time, and health care systems worldwide need to implement interventions to reduce the impact and burden of ..
  8. pmc Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
    Denis J David
    Université Paris Sud EA 3544, Faculte de Pharmacie, Chatenay Malabry Cedex F 92296, France
    Neuron 62:479-93. 2009
    ..Here we describe a mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment...
  9. ncbi Anxiety and cognitive performance: attentional control theory
    Michael W Eysenck
    Department of Psychology, Royal Holloway University of London, London, United Kingdom
    Emotion 7:336-53. 2007
    Attentional control theory is an approach to anxiety and cognition representing a major development of Eysenck and Calvo's (1992) processing efficiency theory...
  10. ncbi Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence
    M R DiMatteo
    Department of Psychology, University of California, Riverside, CA 92521, USA
    Arch Intern Med 160:2101-7. 2000
    Depression and anxiety are common in medical patients and are associated with diminished health status and increased health care utilization...
  11. ncbi The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods
    Brenda W J H Penninx
    Department of Psychiatry EMGO Institute Institute for Neurosciences, VU University Medical Centre, Amsterdam, The Netherlands
    Int J Methods Psychiatr Res 17:121-40. 2008
    The Netherlands Study of Depression and Anxiety (NESDA) is a multi-site naturalistic cohort study to: (1) describe the long-term course and consequences of depressive and anxiety disorders, and (2) to integrate biological and ..
  12. pmc The Hospital Anxiety And Depression Scale
    R Philip Snaith
    Senior Lecturer in Psychiatry, University of Leeds, 21 Gledhow Wood Road, Leeds LS8 4BW, UK
    Health Qual Life Outcomes 1:29. 2003
    There is a need to assess the contribution of mood disorder, especially anxiety and depression, in order to understand the experience of suffering in the setting of medical practice...
  13. ncbi [Measuring the quality of life in economic evaluations: the Dutch EQ-5D tariff]
    L M Lamers
    Instituut Beleid en Management Gezondheidszorg, Erasmus MC, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 149:1574-8. 2005
    ..To value EQ-5D health states by a general Dutch public. EQ-5D is a standardised questionnaire that is used to calculate quality-adjusted life-years for cost-utility analysis...
  14. pmc Effectiveness of a web-based self-help intervention for symptoms of depression, anxiety, and stress: randomized controlled trial
    Annemieke van Straten
    FPP, Department of Clinical Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    J Med Internet Res 10:e7. 2008
    ..We developed a new Web-based self-help intervention based on problem-solving therapy, which may be used for people with different types of comorbid problems: depression, anxiety, and work-related stress.
  15. pmc Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear
    Hans Christian Pape
    Institute of Physiology, Westfaelische Wilhelms University, Muenster, Germany and Rutgers State University, Newark, New Jersey, USA
    Physiol Rev 90:419-63. 2010
    ..that abnormalities in fear learning mechanisms likely participate in the development and/or maintenance of human anxiety disorders...
  16. pmc Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys
    Philip S Wang
    Division of Services and Intervention Research, National Institute of Mental Health, Rockville, MD, USA
    Lancet 370:841-50. 2007
    ..We describe mental health care in 17 countries participating in the WHO world mental health (WMH) survey initiative and examine unmet needs for treatment...
  17. ncbi A review of technology-assisted self-help and minimal contact therapies for anxiety and depression: is human contact necessary for therapeutic efficacy?
    Michelle G Newman
    Department of Psychology, The Pennsylvania State University, University Park, PA 16802 3103, United States
    Clin Psychol Rev 31:89-103. 2011
    ..self-help and minimal contact therapies have been proposed as effective and low-cost interventions for anxiety and mood disorders...
  18. ncbi The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review
    Laetitia Prut
    EA3248, Psychobiologie des Emotions, Faculte des Sciences et Techniques, Universite Francois Rabelias, Parc de Grandmont Avenue Monge, 37200 Tours, France
    Eur J Pharmacol 463:3-33. 2003
    The open field is a very popular animal model of anxiety-like behavior...
  19. ncbi Normative data for the HADS from a large non-clinical sample
    J R Crawford
    Department of Psychology, King s College, University of Aberdeen, Aberdeen AB24 2UB, UK
    Br J Clin Psychol 40:429-34. 2001
    To provide normative data for the Hospital Anxiety Depression Scale (HADS).
  20. ncbi Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy
    A Rozanski
    Division of Cardiology, Department of Medicine, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Circulation 99:2192-217. 1999
    ..evidence is composed largely of data relating CAD risk to 5 specific psychosocial domains: (1) depression, (2) anxiety, (3) personality factors and character traits, (4) social isolation, and (5) chronic life stress...
  21. ncbi The association of depression and anxiety with medical symptom burden in patients with chronic medical illness
    Wayne Katon
    Department of Psychiatry, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
    Gen Hosp Psychiatry 29:147-55. 2007
    Primary care patients with anxiety and depression often describe multiple physical symptoms, but no systematic review has studied the effect of anxiety and depressive comorbidity in patients with chronic medical illnesses.
  22. ncbi Genetics of mouse behavior: interactions with laboratory environment
    J C Crabbe
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97201, USA
    Science 284:1670-2. 1999
    ..For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory...
  23. ncbi Regional dissociations within the hippocampus--memory and anxiety
    D M Bannerman
    Department of Experimental Psychology, University of Oxford, South Parks Road, OX1 3UD, UK
    Neurosci Biobehav Rev 28:273-83. 2004
    ..the consequences of hippocampal damage: Hippocampal lesions also result in behavioural disinhibition and reduced anxiety. A growing number of studies now suggest that these diverse behavioural effects may be associated with different ..
  24. pmc Neuropsin cleaves EphB2 in the amygdala to control anxiety
    Benjamin K Attwood
    Department of Cell Physiology and Pharmacology, University of Leicester, University Road, Leicester LE1 9HN, UK
    Nature 473:372-5. 2011
    A minority of individuals experiencing traumatic events develop anxiety disorders. The reason for the lack of correspondence between the prevalence of exposure to psychological trauma and the development of anxiety is unknown...
  25. pmc Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 314:140-3. 2006
    ..When placed in stressful settings, BDNF(Met/Met) mice exhibited increased anxiety-related behaviors that were not normalized by the antidepressant, fluoxetine...
  26. pmc Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuropharmacology 62:3-12. 2012
    ..The amygdala and the prefrontal cortex, brain regions involved in anxiety and fear, mood, cognitive function and behavioral control, also show structural plasticity...
  27. ncbi MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34
    Sharon Haramati
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 31:14191-203. 2011
    The etiology and pathophysiology of anxiety and mood disorders is linked to inappropriate regulation of the central stress response...
  28. ncbi Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
    Mark S Ansorge
    Sackler Institute for Developmental Psychobiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Science 306:879-81. 2004
    Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown...
  29. ncbi A review of psychological risk factors in back and neck pain
    S J Linton
    Department of Occupational and Environmental Medicine, Orebro Medical Center, Orebro, Sweden
    Spine (Phila Pa 1976) 25:1148-56. 2000
    ..The literature on psychological factors in neck and back pain was systematically searched and reviewed...
  30. ncbi Anxiety, depression and stress in pregnancy: implications for mothers, children, research, and practice
    Christine Dunkel Schetter
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    Curr Opin Psychiatry 25:141-8. 2012
    To briefly review results of the latest research on the contributions of depression, anxiety, and stress exposures in pregnancy to adverse maternal and child outcomes, and to direct attention to new findings on pregnancy anxiety, a ..
  31. ncbi Anxiety measures validated in perinatal populations: a systematic review
    Rose Meades
    School of Psychology, University of Sussex, Brighton, Sussex, UK
    J Affect Disord 133:1-15. 2011
    Research and screening of anxiety in the perinatal period is hampered by a lack of psychometric data on self-report anxiety measures used in perinatal populations...
  32. pmc Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety
    Michael Davis
    Department of Psychiatry, Yerkes National Primate Center, Emory University, and The Center for Behavioral Neuroscience, Atlanta, GA 30329, USA
    Neuropsychopharmacology 35:105-35. 2010
    ..using the acoustic startle reflex in rats and humans based on our attempts to operationally define fear vs anxiety. Although the symptoms of fear and anxiety are very similar, they also differ...
  33. pmc Attention bias modification treatment: a meta-analysis toward the establishment of novel treatment for anxiety
    Yuko Hakamata
    Division of Adult Mental Health, National Institute of Mental Health, Tokyo, Japan
    Biol Psychiatry 68:982-90. 2010
    Attention Bias Modification Treatment (ABMT) is a newly emerging, promising treatment for anxiety disorders...
  34. ncbi Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons
    Ajai Vyas
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    J Neurosci 22:6810-8. 2002
    ..Thus, stress-induced structural plasticity in amygdala neurons may provide a candidate cellular substrate for affective disorders triggered by chronic stress...
  35. ncbi Prefrontal cortical function and anxiety: controlling attention to threat-related stimuli
    Sonia Bishop
    Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Nat Neurosci 7:184-8. 2004
    ..volunteers to study how the processing of threat-related distractors is controlled and whether this alters as anxiety levels increase...
  36. ncbi Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence
    David M Clarke
    Psychological Medicine, Monash University, Melbourne, Vic, Australia
    Med J Aust 190:S54-60. 2009
    To review the evidence for an association between depression and anxiety and the National Health Priority Area conditions -- heart disease, stroke, diabetes mellitus, asthma, cancer, arthritis and osteoporosis -- and for the ..
  37. ncbi Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces
    Amit Etkin
    Center for Neurobiology and Behavior, Columbia University Medical Center, fMRI Research Center, 170 West 168th Street, Box 108, New York, New York 10032, USA
    Neuron 44:1043-55. 2004
    ..conscious and unconscious processes, but the neural systems underlying these processes and their relationship to anxiety have not been clearly delineated...
  38. ncbi Cognitive theory and therapy of anxiety and depression: convergence with neurobiological findings
    David A Clark
    Department of Psychology, University of New Brunswick, P O Box 4400, Fredericton, New Brunswick E3B5A3, Canada
    Trends Cogn Sci 14:418-24. 2010
    In this review paper a modified cognitive neurophysiological model of Aaron T. Beck's cognitive formulation of anxiety and depression is proposed that provides an elaborated account of the cognitive and neural mediational processes of ..
  39. pmc Yoga for anxiety: a systematic review of the research evidence
    G Kirkwood
    Research Council for Complementary Medicine, London, UK
    Br J Sports Med 39:884-91; discussion 891. 2005
    ..a systematic review was carried out of the research evidence on the effectiveness of yoga for the treatment of anxiety and anxiety disorders. Eight studies were reviewed...
  40. ncbi A meta-analysis of the effect of cognitive bias modification on anxiety and depression
    Lauren S Hallion
    Department of Psychology, University of Pennsylvania, Philadelphia, USA
    Psychol Bull 137:940-58. 2011
    Cognitive biases have been theorized to play a critical role in the onset and maintenance of anxiety and depression...
  41. pmc Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 103:3480-5. 2006
    ..These results suggest that early-life experience has a stable and broad effect on the hippocampal transcriptome and anxiety-mediated behavior, which is potentially reversible in adulthood.
  42. pmc A comparison of changes in anxiety and depression symptoms of spontaneous users and trial participants of a cognitive behavior therapy website
    Helen Christensen
    Centre for Mental Health Research, The Australian National University, Canberra ACT, 0200, Australia
    J Med Internet Res 6:e46. 2004
    In randomized controlled trials Internet sites have been shown to be effective in the treatment of depression and anxiety. However, it is unclear if the positive effects demonstrated in these trials transfer to community users of such ..
  43. ncbi Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex
    Shuichi Chiba
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 39:112-9. 2012
    ..We investigated the effects of chronic restraint stress (CRS: 6 hours × 28 days) on anxiety- and depression-like behaviors in rats and on the possible changes in glucocorticoid receptor (GR) expression as ..
  44. ncbi New insights into BDNF function in depression and anxiety
    Keri Martinowich
    Mood and Anxiety Program, National Institute of Mental Health, Building 35, Room 1C1004, 35 Convent Drive, MSC 3714, Bethesda, Maryland 20892 3714, USA
    Nat Neurosci 10:1089-93. 2007
    ..Thus, BDNF may be a target of antidepressants, but not the sole mediator of depression or anxiety. Advances in BDNF cell biology, including its transcription through multiple promoters, trafficking and secretion,..
  45. ncbi Insomnia, worry, anxiety and depression as predictors of the occurrence and persistence of paranoid thinking
    Daniel Freeman
    Department of Psychiatry, Warneford Hospital, Oxford University, Oxford, OX3 7JX, UK
    Soc Psychiatry Psychiatr Epidemiol 47:1195-203. 2012
    ..b>Anxiety produces anticipation of threat, depression increases the sense of vulnerability, worry leads to implausible ..
  46. ncbi Treatments for anxiety and depression in patients with chronic obstructive pulmonary disease: a literature review
    Paul A Cafarella
    Department of Respiratory Medicine, Repatriation General Hospital, Adelaide, South Australia, Australia
    Respirology 17:627-38. 2012
    ..Psychological co-morbidities such as anxiety and depression are common in COPD...
  47. ncbi Mechanisms of fear extinction
    K M Myers
    Center for Behavioral Neuroscience, Emory University, Atlanta, GA, USA
    Mol Psychiatry 12:120-50. 2007
    Excessive fear and anxiety are hallmarks of a variety of disabling anxiety disorders that affect millions of people throughout the world...
  48. pmc Describing the interplay between anxiety and cognition: from impaired performance under low cognitive load to reduced anxiety under high load
    Katherine Vytal
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Psychophysiology 49:842-52. 2012
    b>Anxiety impairs the ability to think and concentrate, suggesting that the interaction between emotion and cognition may elucidate the debilitating nature of pathological anxiety...
  49. pmc The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
    Alicia A Walf
    Department of Psychology, The University at Albany SUNY, Albany, New York, USA
    Nat Protoc 2:322-8. 2007
    The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain regions and mechanisms underlying ..
  50. ncbi Trait anxiety and impoverished prefrontal control of attention
    Sonia J Bishop
    Department of Psychology and Helen Wills Neuroscience Institute, Tolman Hall 1650, University of California Berkeley, Berkeley, California 94720 1650, USA
    Nat Neurosci 12:92-8. 2009
    Many neurocognitive models of anxiety emphasize the importance of a hyper-responsive threat-detection system centered on the amygdala, with recent accounts incorporating a role for prefrontal mechanisms in regulating attention to threat...
  51. pmc The adaptive threat bias in anxiety: amygdala-dorsomedial prefrontal cortex coupling and aversive amplification
    Oliver J Robinson
    Section on Neurobiology of Fear and Anxiety, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 2670, USA
    Neuroimage 60:523-9. 2012
    Functionally, anxiety serves to increase vigilance towards aversive stimuli and improve the ability to detect and avoid danger...
  52. ncbi Normative values for the hospital anxiety and depression scale (HADS) in the general German population
    Andreas Hinz
    Department of Medical Psychology and Medical Sociology, University of Leipzig, Germany
    J Psychosom Res 71:74-8. 2011
    The aim of this study was to present normative values for the Hospital Anxiety and Depression Scale (HADS).
  53. ncbi Anxiety and depression in patients with chronic obstructive pulmonary disease (COPD). A review
    Rie Lambaek Mikkelsen
    Psychiatric Center Gentofte, Niels Andersens, Hellerup, Denmark
    Nord J Psychiatry 58:65-70. 2004
    A review of the literature revealed high comorbidity of chronic obstructive pulmonary disease (COPD) and states of anxiety and depression, indicative of excess, psychiatric morbidity in COPD...
  54. ncbi Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years. Report from the Avon Longitudinal Study of Parents and Children
    Thomas G O'Connor
    Institute of Psychiatry, Denmark Hill, London
    Br J Psychiatry 180:502-8. 2002
    Animal experiments suggest that maternal stress and anxiety during pregnancy have long-term effects on the behaviour of the offspring.
  55. ncbi Attention training toward and away from threat in social phobia: effects on subjective, behavioral, and physiological measures of anxiety
    Alexandre Heeren
    Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Behav Res Ther 50:30-9. 2012 which probes always replace nonthreatening cues, reduce attentional bias for threat and self-reported social anxiety. However, researchers have seldom included behavioral measures of anxiety reduction, and have never taken ..
  56. pmc Risk factors for depressive symptoms during pregnancy: a systematic review
    Christie A Lancaster
    University of Michigan, Ann Arbor, 48109 5604, USA
    Am J Obstet Gynecol 202:5-14. 2010
    ..In total, 57 studies met eligibility criteria. Maternal anxiety, life stress, history of depression, lack of social support, unintended pregnancy, Medicaid insurance, domestic ..
  57. pmc Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring
    Elinor L Sullivan
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA
    J Neurosci 30:3826-30. 2010
    Childhood obesity is associated with increased risk of behavioral/psychological disorders including depression, anxiety, poor learning, and attention deficient disorder...
  58. ncbi International experiences with the Hospital Anxiety and Depression Scale--a review of validation data and clinical results
    C Herrmann
    Department of Psychosomatics and Psychotherapy, University of Gottingen, Germany
    J Psychosom Res 42:17-41. 1997
    More than 200 published studies from most medical settings worldwide have reported experiences with the Hospital Anxiety and Depression Scale (HADS) which was specifically developed by Zigmond and Snaith for use with physically ill ..
  59. ncbi Measuring anxiety in zebrafish: a critical review
    Caio Maximino
    Laboratorio de Neuroendocrinologia, Instituto de Ciencias Biologicas, Universidade Federal do Para, Belem PA, Brazil
    Behav Brain Res 214:157-71. 2010
    ..Recently, behavioral screens used to model anxiety in rodents were adapted to this species, and novel models which tap on zebrafish behavioral ecology have emerged...
  60. pmc Amygdala circuitry mediating reversible and bidirectional control of anxiety
    Kay M Tye
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 471:358-62. 2011
    b>Anxiety--a sustained state of heightened apprehension in the absence of immediate threat--becomes severely debilitating in disease states...
  61. ncbi Review of internet-based prevention and treatment programs for anxiety and depression in children and adolescents
    Alison L Calear
    Centre for Mental Health Research, Australian National University, Canberra, ACT, Australia
    Med J Aust 192:S12-4. 2010
    To identify and describe current internet-based prevention and treatment programs for anxiety and depression in children and adolescents.
  62. ncbi Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease
    Sadim Jawhar
    Division of Molecular Psychiatry, Alzheimer Ph D, Graduate School, Department of Psychiatry, University of Goettingen, Von Siebold Str 5, 37075 Goettingen, Germany
    Neurobiol Aging 33:196.e29-40. 2012
    ..that these mice develop an age-dependent motor phenotype in addition to working memory deficits and reduced anxiety levels as demonstrated in an elevated plus maze task...
  63. ncbi Predictors of postpartum depression: an update
    C T Beck
    School of Nursing, University of Connecticut, Storrs 06269, USA
    Nurs Res 50:275-85. 2001
    ..Approximately 13% of women experience postpartum depression. Early recognition is one of the most difficult challenges with this mood disorder because of how covertly it is suffered...
  64. pmc Threatening a rubber hand that you feel is yours elicits a cortical anxiety response
    H Henrik Ehrsson
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 104:9828-33. 2007
    ..we show that threat to the rubber hand can induce a similar level of activity in the brain areas associated with anxiety and interoceptive awareness (insula and anterior cingulate cortex) as when the person's real hand is threatened...
  65. pmc Mothers' anxiety during pregnancy is associated with asthma in their children
    Hannah Cookson
    Department of Internal Medicine, Sir Charles Gairdner Hospital, Perth, Australia
    J Allergy Clin Immunol 123:847-53.e11. 2009
    ..The association of asthma with prenatal exposure to maternal stress has not been reported...
  66. ncbi Burden, depression, and anxiety in caregivers of people with amyotrophic lateral sclerosis
    Francesco Pagnini
    Department of Psychology, Catholic University of Milan, Milan, Italy
    Psychol Health Med 15:685-93. 2010
    ..conducted a cross-sectional study among 40 ALS caregivers, assessing general worries, burden of care, depression, anxiety, perception of social support, and patients' severity of disease...
  67. ncbi An insular view of anxiety
    Martin P Paulus
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92037, USA
    Biol Psychiatry 60:383-7. 2006
    We propose a general hypothesis that integrates affective and cognitive processing with neuroanatomy to explain anxiety pronenes. The premise is that individuals who are prone to anxiety show an altered interoceptive prediction signal, i...
  68. pmc Anxiety and depression in COPD: current understanding, unanswered questions, and research needs
    Janet Maurer
    Chest 134:43S-56S. 2008
    ..b>Anxiety and depression are very common comorbidities in COPD and have significant impact on patients, their families, ..
  69. ncbi The YouthMood Project: a cluster randomized controlled trial of an online cognitive behavioral program with adolescents
    Alison L Calear
    Centre for Mental Health Research, The Australian National University, ACT 0200, Australia
    J Consult Clin Psychol 77:1021-32. 2009, self-directed cognitive-behavioral therapy program (MoodGYM) in preventing and reducing the symptoms of anxiety and depression in an adolescent school-based population...
  70. pmc Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish
    Rupert J Egan
    Stress Physiology and Research Center SPaRC, Department of Physiology and Biophysics, Georgetown University Medical School, 3900 Reservoir Road, Washington, DC 20057, USA
    Behav Brain Res 205:38-44. 2009
    The zebrafish (Danio rerio) is emerging as a promising model organism for experimental studies of stress and anxiety. Here we further validate zebrafish models of stress by analyzing how environmental and pharmacological manipulations ..
  71. pmc Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus
    Mazen A Kheirbek
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Neuron 77:955-68. 2013
    ..gyrus (DG), in addition to its role in learning and memory, is increasingly implicated in the pathophysiology of anxiety disorders...
  72. pmc The effect of state anxiety on paranoid ideation and jumping to conclusions. An experimental investigation
    Tania M Lincoln
    Section for Clinical Psychology and Psychotherapy, Faculty of Psychology, Philipps Universitat Marburg, Gutenbergstr 18, 35032 Marburg, Germany
    Schizophr Bull 36:1140-8. 2010
    ..However, the causal mechanisms remain unclear. This study tests the hypothesis that state anxiety will increase paranoid ideation and that this increase will be moderated by the level of individual vulnerability ..
  73. pmc Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses
    D L Walker
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA 30329, USA
    Prog Neuropsychopharmacol Biol Psychiatry 33:1291-308. 2009
    ..More recent studies have shown that the BNST does participate in some types of anxiety and stress responses...
  74. pmc Modeling anxiety using adult zebrafish: a conceptual review
    Adam Stewart
    Department of Pharmacology and Neuroscience Program, Tulane Neurophenotyping Platform, Zebrafish Neuroscience Research Consortium, Tulane University Medical School, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Neuropharmacology 62:135-43. 2012
    ..Mounting evidence shows the suitability of zebrafish to model various aspects of anxiety-related states...
  75. ncbi The positive and negative affect schedule (PANAS): construct validity, measurement properties and normative data in a large non-clinical sample
    John R Crawford
    Department of Psychology, King s College, University of Aberdeen, UK
    Br J Clin Psychol 43:245-65. 2004
    ..To evaluate the reliability and validity of the PANAS (Watson, Clark, & Tellegen, 1988b) and provide normative data...
  76. ncbi The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample
    Julie D Henry
    School of Psychology, University of New South Wales, Australia
    Br J Clin Psychol 44:227-39. 2005
    To test the construct validity of the short-form version of the Depression anxiety and stress scale (DASS-21), and in particular, to assess whether stress as indexed by this measure is synonymous with negative affectivity (NA) or whether ..
  77. ncbi Little things on which happiness depends: microRNAs as novel therapeutic targets for the treatment of anxiety and depression
    R M O'Connor
    School of Pharmacy, University College Cork, Cork, Ireland
    Mol Psychiatry 17:359-76. 2012
    b>Anxiety and depression are devastating mental illnesses that are a significant public health concern...
  78. ncbi Neural systems involved in fear and anxiety measured with fear-potentiated startle
    Michael Davis
    Emory University, Atlanta, GA, USA
    Am Psychol 61:741-56. 2006
    ..CeA-mediated behaviors may represent stimulus-specific fear, whereas BNST-mediated behaviors are more akin to anxiety. NMDA receptors are also involved in extinction of conditioned fear, and both extinction in rats and exposure-..
  79. pmc Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion
    Christopher Barkus
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
    Eur J Pharmacol 626:49-56. 2010
    ..NMDA receptor antagonists affect various aspects of emotionality including fear, anxiety and depression, as well as impairing certain forms of learning and memory...
  80. pmc Anxiety and depression symptoms as risk factors for non-adherence to antiretroviral therapy in Brazil
    Lorenza Nogueira Campos
    Department of Preventive and Social Medicine, School of Medicine, Federal University of Minas Gerais, Av Prof Alfredo Balena 190, Bairro Santa Efigênia, CEP 30130 100, Belo Horizonte, MG, Brazil
    AIDS Behav 14:289-99. 2010
    Depression and anxiety are common among HIV-infected people and rank among the strongest predictors of non-adherence to antiretroviral therapy (ART)...
  81. pmc Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior
    Matteo Bergami
    Department of Human and General Physiology, University of Bologna, via San Donato 19 2, I 40126 Bologna, Italy
    Proc Natl Acad Sci U S A 105:15570-5. 2008
    ..Because of the specific lack of TrkB signaling in recently generated neurons a remarkably increased anxiety-like behavior was observed in mice carrying the mutation, emphasizing the contribution of adult neurogenesis in ..
  82. ncbi Comorbidity patterns of anxiety and depressive disorders in a large cohort study: the Netherlands Study of Depression and Anxiety (NESDA)
    Femke Lamers
    Department of Psychiatry EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Psychiatry 72:341-8. 2011
    Comorbidity of depressive and anxiety disorders is common and has been shown to be a consistent predictor of chronicity. Comorbidity patterns among specific depressive and anxiety disorders have not been extensively reported...
  83. ncbi Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
    T L Bale
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA
    Nat Genet 24:410-4. 2000
    ..Crhr2-mutant mice are hypersensitive to stress and display increased anxiety-like behaviour...
  84. ncbi Anxiety and depression symptoms in psychometrically identified schizotypy
    Kathryn E Lewandowski
    University of North Carolina at Greensboro, Department of Psychology, 296 Eberhart Building, Greensboro, NC 27402, USA
    Schizophr Res 83:225-35. 2006
    ..Given that depression and anxiety are reported to be comorbid with schizophrenia, the present study examined the relationship of psychometrically ..
  85. ncbi The neurobiology and control of anxious states
    Mark J Millan
    Psychopharmacology Department, Centre de Rescherches de Croissy, Institut de Recherches IDR Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Prog Neurobiol 70:83-244. 2003 may be symptomatic of a debilitating anxious state: for example, social phobia, panic attacks or generalized anxiety disorder...
  86. pmc Association between amygdala response to emotional faces and social anxiety in autism spectrum disorders
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Neuropsychologia 48:3665-70. 2010
    ..In addition, we investigated whether there was a relationship between self-reported social anxiety and fMRI activation...
  87. ncbi Anxiety and affective style: role of prefrontal cortex and amygdala
    Richard J Davidson
    Laboratory for Affective Neuroscience, Department of Psychology, University of Wisconsin Madison, 1202 West Johnson Street, Madison, WI 53706, USA
    Biol Psychiatry 51:68-80. 2002
    ..tonic activation and phasic reactivity in this circuit play an important role in governing different aspects of anxiety. Emphasis is placed on affective chronometry, or the time course of emotional responding, as a key attribute of ..
  88. ncbi Effects of chronic fluoxetine in animal models of anxiety and depression
    Stephanie C Dulawa
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuropsychopharmacology 29:1321-30. 2004
    ..reuptake inhibitor fluoxetine (0, 5, 10 mg/kg/day in drinking water), which is used for the treatment of mood and anxiety disorders. Only the highly anxious BALB/c strain exhibited sensitivity to fluoxetine in the forced swim test...
  89. ncbi Cost-effectiveness of computerised cognitive-behavioural therapy for anxiety and depression in primary care: randomised controlled trial
    Paul McCrone
    Centre for the Economics of Mental Health, Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 185:55-62. 2004
    Cognitive-behavioural therapy (CBT) is effective for treating anxiety and depression in primary care, but there is a shortage of therapists. Computer-delivered treatment may be a viable alternative.
  90. ncbi Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior
    Timothy J Hendricks
    Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Neuron 37:233-47. 2003
    ..Significantly, defective development of the 5-HT system is followed by heightened anxiety-like and aggressive behavior in adults...
  91. ncbi Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
    P Timpl
    Max Planck Institute of Psychiatry, Munich, Germany
    Nat Genet 19:162-6. 1998
    ..The homozygous mutants exhibit increased exploratory activity and reduced anxiety-related behaviour under both basal conditions and following alcohol withdrawal...
  92. ncbi Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development
    G W Smith
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Neuron 20:1093-102. 1998
    ..Behavioral analyses revealed that mice lacking CRFR1 displayed markedly reduced anxiety. Mutant mice also failed to exhibit the characteristic hormonal response to stress due to a disruption of the ..
  93. pmc Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation
    Mariusz Mucha
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 108:18436-41. 2011
    ..The above changes correlated with higher excitability of CA1 principal neurons and with elevated stress-induced anxiety in Lcn-2(-/-) mice...
  94. ncbi Cognitive bias modification approaches to anxiety
    Colin MacLeod
    School of Psychology, The University of Western Australia, Crawley WA 6009 Australia
    Annu Rev Clin Psychol 8:189-217. 2012
    Clinical anxiety disorders and elevated levels of anxiety vulnerability are characterized by cognitive biases, and this processing selectivity has been implicated in theoretical accounts of these conditions...
  95. pmc The effect of induced anxiety on cognition: threat of shock enhances aversive processing in healthy individuals
    Oliver J Robinson
    Mood and Anxiety Disorders Program, NIMH, 15K North Drive, MSC 2670, Bethesda, MD 20892, USA
    Cogn Affect Behav Neurosci 11:217-27. 2011
    Individuals with anxiety disorders demonstrate altered cognitive performance including (1) cognitive biases towards negative stimuli (affective biases) and (2) increased cognitive rigidity (e.g...
  96. ncbi Acupuncture for anxiety and anxiety disorders--a systematic literature review
    Karen Pilkington
    School of Integrated Health, University of Westminster, London, UK
    Acupunct Med 25:1-10. 2007
    The aim of this study was to evaluate the evidence for the efficacy of acupuncture in the treatment of anxiety and anxiety disorders by systematic review of the relevant research.
  97. ncbi A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder
    Adam J Guastella
    School of Psychology, University of New South Wales, Sydney, Australia
    Psychoneuroendocrinology 34:917-23. 2009 was to determine whether oxytocin given as an adjunct to exposure therapy improves treatment for social anxiety disorder (SAD) as indicated by a comprehensive set of symptom outcome measures...
  98. pmc GSK3 influences social preference and anxiety-related behaviors during social interaction in a mouse model of fragile X syndrome and autism
    Marjelo A Mines
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e9706. 2010
    ..This used two mouse models with disrupted regulation of GSK3, Fmr1 knockout mice and GSK3 knockin mice, in which inhibitory serines of the two isoforms of GSK3, GSK3alpha and GSK3beta, are mutated to alanines, leaving GSK3 fully active...
  99. ncbi Endocannabinoid system and stress and anxiety responses
    M P Viveros
    Departmento de Fisiología Fisiología Animal II, Facultad de Biologia, Universidad Complutense, 28040 Madrid, Spain
    Pharmacol Biochem Behav 81:331-42. 2005
    Cannabinoid agonists induce complex and often contradictory effects on anxiety in humans and experimental animals...
  100. pmc Differential stress-induced neuronal activation patterns in mouse lines selectively bred for high, normal or low anxiety
    Patrik Muigg
    Department of Pharmacology and Toxicology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Innsbruck, Austria
    PLoS ONE 4:e5346. 2009
    There is evidence for a disturbed perception and processing of emotional information in pathological anxiety. Using a rat model of trait anxiety generated by selective breeding, we previously revealed differences in challenge-induced ..
  101. pmc Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks
    F E Harrison
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Behav Brain Res 198:247-51. 2009
    ..In the present study, mice matched for performance on commonly used anxiety tasks were trained on either the Barnes maze or water maze or received no cognitive testing...

Research Grants77

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Hypothalamic Orexin Role in Menopause-Associated Hot Flashes and Mood/Sleep Disru
    PHILIP LEE JOHNSON; Fiscal Year: 2013
    ..role in sleep wakes cycles, and our recent preclinical and clinical data linking a hyperactive orexin system to anxiety and temperature dysregulation;3) we will conduct animal studies to elucidate the mechanisms underlying orexin ..
  3. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    ..Impairment of memory and concentration, increased anxiety, irritability and mood instability, and sleep disturbance interfere with job and family relationships, producing ..
  4. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    ..My career objective is to conduct independent research to understand how stress and affect interact and elucidate their respective roles in the etiology of mental disorders like depression and anxiety.
  5. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..activity, CGRP is involved in many neural processes including nociception, neurogenic inflammation, migraine and anxiety. The CGRP receptor has an obligatory requirement for a subunit called Receptor Activity-Modifying Protein 1 (..
  6. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..steroids synthesized de novo in the brain, have been implicated in functions ranging from stress, depression, anxiety, to cognition. One neurosteroid is progesterone, a classic sex hormone involved in the regulation of reproduction...
  7. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..In most cases, overactive bladder symptoms are associated with insomnia, anxiety, fatigue, and even depression...
  8. Remodeling Neuronal Chromatin in Mouse Models for Depression
    Schahram Akbarian; Fiscal Year: 2013
    ..followed by genome-wide profiling, (d) behavioral assays measuring despair and learned helplessness, anxiety, and learning and memory and (e) functional characterization of NMDA receptors in hippocampus and other brain ..
  9. Neural mechanisms by which chronic stress regulates inflammation in asthma
    Melissa A Rosenkranz; Fiscal Year: 2013
    ..S. adults. Individuals with asthma have a two-fold higher risk of developing a mood or anxiety disorder than those without asthma and this co-morbidity is associated with poorer asthma control, increased ..
  10. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
    ..Amygdaloid brain structures are known to play an important role in anxiety behaviors...
  11. Efficacy of Yoga for Treatment-Resistant PTSD
    Bessel Van der Kolk; Fiscal Year: 2010
    ..thousands of women in the US? Research has demonstrated a close association between trauma exposure and 1) PTSD, anxiety &depression, 2) loss of affect regulation, 3) poor quality of life, and 4) high health care utilization (2, 3)..
  12. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..component of the circuitry that is necessary for the processes of learning, memory, attention, sleep, arousal, anxiety, and responses to stress...
  13. Understanding Pain of Gastrointestinal Origin in Women that Serve in OEF/OIF
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..Of particular interest to this proposal, veterans suffering from anxiety-related disorders such as PTSD have higher rates of adverse childhood experiences and abuse...
  14. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..are monitored by attaching a host of devices and sensors with significant cabling that often generates parental anxiety and complicates treatment;no easy and effective at-home solution exists...
  15. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    ..WHO Essential Drug List and those on the market, such as Valium and Xanax, are widely used for the treatment of anxiety, panic attacks, insomnia, agitation and seizures...
  16. Characterization of epsilon-sarcoglycan interacting proteins in mouse brain
    Yuqing Li; Fiscal Year: 2012
    ..We found that the Sgce knockout mice showed myoclonus, motor deficits indicative of dystonia, anxiety, depression, and changes in the dopaminergic and serotonergic systems...
  17. Signaling Mechanisms in Alcohol Drinking Behaviors
    Subhash C Pandey; Fiscal Year: 2013
    ..Evidence also indicates that negative reinforcing factors, such as high anxiety levels, may play an important role in alcohol use and abuse...
  18. Predicting Bilirubin-induced Auditory Toxicity in Infants with Severe Jaundice
    Sanjiv B Amin; Fiscal Year: 2010 transfusions and associated complications, 4) unnecessary auditory evaluations, and 5) parental anxiety and emotional stress...
  19. Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol A
    CHERYL SUSAN ROSENFELD; Fiscal Year: 2010
    ..Pre- and post-weaning behavioral assessments will be performed on the pups to determine whether BPA affects their anxiety levels, learning and memory responses, and other developmental parameters...
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2012
    ..Significant effects of reproductive experience on anxiety-like behavior were also found in reproductively experienced animals during their subsequent reproductive cycles ..
  21. Role of TPH2 and 5HT Neuronal Loss in Non-motor Symptoms of Parkinson's
    Donald M Kuhn; Fiscal Year: 2012
    ..80% of PD patients suffer from co-morbid neuropsychiatric conditions like depression, sleep disorders, anxiety and dementia. Many of these conditions have been linked to dysfunctional 5HT neurochemistry...
  22. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ..Seasonal changes in human behavioral pathology are also observed in anxiety and depression, migraine headaches, as well as incidence, severity, and mortality of strokes...
  23. Combined BAC Transgenic and Knock-Out Mouse Model of Lowe Syndrome Nephropathy
    Robert L Nussbaum; Fiscal Year: 2013
    ..Finally, after completing a 10-generation backcross onto C57Bl/6, we will examine the mice for abnormalities in central nervous system by testing motor function, anxiety, learning, memory and by examining the brains neuropathologically.
    Bruce S McEwen; Fiscal Year: 2013
    ..Stress can also have deleterious effects, including mood alterations and anxiety that, if they persist after the stressor is terminated, can become an anxiety or depressive disorder...
  25. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The understanding and treatment of pathological anxiety have long been a prime concern in regard to mental health...
  26. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    ..commonly report significant reductions in quality of life, as well as social stigmatization, increased rates of anxiety and depression, and increased thoughts of suicide...
  27. Fall risk assessment and prevention in elderly with diabetes using wearable techn
    Bor Rong Chen; Fiscal Year: 2012
    ..DPN) frequently exhibit concomitant postural instability that can lead to falls, fracture, depression, anxiety, and decreased quality of life. Individuals with diabetes are 2...
  28. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..levels or a lack of estrogens, including decreased sexual motivation, hot flushes, sleep disorders, depression/anxiety, brain and spinal cord trauma, amyotrophic lateral sclerosis, and cognitive dysfunction...
  29. Identifying underlying mechanisms of intracellular changes in response to caregiv
    MELANIE SARAH FLINT; Fiscal Year: 2013
    ..g., high levels of depressive symptoms, burden, anxiety and reports of poor overall health), has been well documented...
  30. RNA interference therapy for Huntington's disease: studies in non-human primates
    Beverly L Davidson; Fiscal Year: 2010
    ..RNAi therapy for other brain disorders in the NHP, such as neuropathic pain, encephalitis, various carcinomas, anxiety and depression...
  31. Anxiety development in 5-HT1A autoreceptor knockout mice, interaction with stress
    Rene Hen; Fiscal Year: 2010
    ..The disorder under investigation is anxiety. Anxiety can be defined as a state of cognitive and behavioral preparedness that an organism mobilizes in ..
  32. Implantation of physiologically functional bioengineered innervated IAS construct
    Khalil N Bitar; Fiscal Year: 2010
    ..Individuals who are incontinent may experience anxiety about "accidents," depression, social isolation, and social exclusion...
  33. Robot-Assisted MRI-Guided Prostate Biopsy
    Dan Stoianovici; Fiscal Year: 2010
    ..Most importantly, this could improve PC management for fewer related complications, less patient anxiety and physician stress, and hopefully lessen the 15% current rate of PC death...
  34. Serotonin transporter-mediated regulation of neuroendocrine exocytosis
    KEVIN P CURRIE; Fiscal Year: 2013
    ..Genetic variations in SERT are associated with several neuropsychiatric disorders including depression, anxiety, obsessive compulsive disorder, and autism...
  35. Neuroendocrine Mechanisms and Therapeutics in an Animal Model of PTSD
    DAVID MARK DIAMOND; Fiscal Year: 2013
    ..This psychosocial stress manipulation produces PTSD-like sequelae in rats, including heightened anxiety, exaggerated startle, impaired memory, greater cardiovascular and hormonal reactivity to an acute stressor and an ..
  36. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2009 a syndrome of recurrent abdominal pain, diarrhea and psychological conditions such as depression and anxiety. Based on the principle of TCM, as mentioned in the Yellow Emperor's Inner Classics, the most ancient TCM ..
  37. Mechanisms of structural plasticity in stress-related disorders
    Scott J Russo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mood and anxiety disorders such as major depressive disorder (MDD) and post traumatic stress disorder (PTSD) cause overlapping behavioral symptoms marked by hyperarousal, social avoidance, anxiety, ..
  38. Derivation of cerebral cortical GABAergic interneurons from human iPS cells
    Lorenz P Studer; Fiscal Year: 2010
    ..cortex has been implicated in a variety of major neuropsychiatric illnesses, including schizophrenia, autism, anxiety, and epilepsy (where depression is a major source of morbidity)...
  39. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..Deficits in serotonin appear to precipitate depression and anxiety disorders more frequently in women, but deficits in serotonin in men often underlie irritability, hostility, ..
  40. Melanin-Concentrating Hormone: Ancestral Role in Feeding &Sleep Regulation
    Philippe Mourrain; Fiscal Year: 2013
    ..a large spectrum of behaviors associated with energy unbalance, food search and consumption, such as exploration, anxiety, aggressiveness, bulimic like behaviors versus slow eating, and the hedonistic influence of food...
  41. Dopamine Transporter Structure and Function
    Christopher K Surratt; Fiscal Year: 2010
    ..Additionally, these studies may lead to therapeutics for other DAT-related conditions including depression, anxiety disorders, attention deficit hyperactivity disorder, narcolepsy, chronic pain and Parkinson's disease...
  42. In vivo targeted gene silencing, a novel method
    WILLIAM ANTHONY TRUITT; Fiscal Year: 2012
    ..These Tacr1 interneurons receive cortical inputs related to social recognition and suppress anxiety-like outputs of BLA projection neurons...
  43. A Pilot Study of Yoga for Breathing and Quality of Life of Lung Cancer Patients
    ..Fear and anxiety is further intensified due to respiratory compromise, increasing stress, and impairing sleep and mood...
  44. Inducible recombination and gene expression in specific neurotransmitter systems
    Steven A Thomas; Fiscal Year: 2012
    ..and learning and memory, as well as disorders related to these processes that include narcolepsy, drug abuse, anxiety, depression and post- traumatic stress disorder...
  45. Dissecting the role of one neuronal RhoGEF amongst many: the Kalirin-7 null mouse
    Richard E Mains; Fiscal Year: 2012
    ..When tested in the elevated zero maze, Kal7+/KO and Kal7KO mice show a graded decrease in anxiety-like behavior...
  46. Integrated PTSD and Smoking Treatment
    Mark B Powers; Fiscal Year: 2013
    ..I have observed that smoking is prevalent among patients who present for the treatment of PTSD, and that anxiety processes often serve to smoking. A growing body of research supports these observations...
  47. PTSD Hyperarousal Symptoms Treated with Physiological Stress Management
    WALTON THOMPSON ROTH; Fiscal Year: 2011
    ..PTSD support the idea that regulation of autonomic arousal from the cingulate cortex can be helpful in reducing anxiety. Our main objectives are to measure hyperarousal in VA outpatients with PTSD related to combat experience in the ..
  48. Epigenetic Changes in the Glucocorticoid Receptor Gene Due to Arsenic Exposure
    Andrea M Allan; Fiscal Year: 2013
    ..we have found that moderate arsenic-exposure (50 ppb) reduced performance on a variety of learning and memory, anxiety and depression associated tasks and significantly altered the hypothalamic-pituitary-adrenal axis (HPA) function...
  49. Function and Structure Adaptations in Forebrain Development
    PAT R LEVITT; Fiscal Year: 2013
    ..of HGF-Met signaling results in alterations in cortical interneuron development, intermittent seizures, increased anxiety and reduced social behavior in mice...
  50. Novel therapy for monoamine neurotransmitter deficiency in PKU
    Cary O Harding; Fiscal Year: 2013
    ..Chronic hyperphenylalaninemia is frequently associated with anxiety, depression, and impaired executive function such as difficulties with concentration and short-term memory...
  51. A translational model of neuro-immune therapy for PTSD in veterans of the OEF/OIF
    Leonardo H Tonelli; Fiscal Year: 2013
    ..stress disorder (PTSD) is one of the most common war-related illness and is highly comorbid with other anxiety disorders...
  52. Monoamine Contributions to Neurocircuitry in Eating Disorders
    Walter H Kaye; Fiscal Year: 2013
    ..11C]DASB binding may help to explain the neurobiology responsible for an elevated harm avoidance (a measure of anxiety and inhibition) trait in ED...
  53. Development and Regulation of Cholinergic Synapses
    Andres Villu Maricq; Fiscal Year: 2013
    ..One receptor in particular, the homomeric a7 AChR, is associated with autism, anxiety and schizophrenia...
  54. Serotonin Receptor Modulation of Neurotrophic Factors in the Retina
    Mark E Pennesi; Fiscal Year: 2013
    ..or paroxetine, have been widely and safely used to treat a number of psychiatric diseases such as depression and anxiety. There is mounting evidence showing that the anti-depressive effects of SSRIs result from increased expression of ..
  55. Cannabinoid regulation of glycogen synthase kinase-3
    Cecilia J Hillard; Fiscal Year: 2013
    ..3) to determine the role of ss-arrestin in the effects of CB1R agonists and antagonists in behavioral assays of anxiety and stress by comparing their effects in wild type and ss-arrestin-2 null mice...
  56. Mechanisms of Ubiquitin Trafficking in Neurons
    Michael C Wooten; Fiscal Year: 2013
    ..such as tau-phosphorylation, loss of short term memory and synaptic plasticity, reduced serum BDNF, depression, anxiety, along with accumulation of highly insoluble polyubiquitinated proteins in the adult mice...
  57. Oxidative Stress: A Recipe for Anxiety
    Samina Salim; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Anxiety is a normal human emotion that everyone experiences at some point. To feel anxious before a situation is normal and it usually ends soon after one is out of the situation that caused it...
  58. Immediate and Delayed Effects of Morphine on Brain Circuits: Animal and Human Cor
    Dusica Bajic; Fiscal Year: 2013 the absence of pain, critically ill neonates and children receive prolonged opioids for sedation to reduce anxiety, agitation, stress responses, and to facilitate ventilation...
  59. Human VGF Polymorphisms and Depression
    Stephen R Salton; Fiscal Year: 2010
    ..of VGF knock-in mice will be examined in spatial and contextual fear memory tasks, and in depression and anxiety testing...
  60. Integrated Treatment for Smoking Cessation &Anxiety in People with HIV
    Michael J Zvolensky; Fiscal Year: 2013
    ..risk for being current smokers and that quitting smoking may be particularly difficult for individuals with anxiety problems...
  61. Ligand Interaction of Glucagon Receptor by Structural and Functional Analyses
    FAI YIU SIU; Fiscal Year: 2012
    ..conditions such as diabetes, osteoporosis, cancer, obesity, and neurological disorders, including depression and anxiety. The goal of this proposal is to elucidate details of ligand binding and induced signaling of the class-B ..
  62. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012
    ..Such mental complications including depression and anxiety disorders impose a great burden to these patients which has been also related to the poor prognosis of the ..
  63. Use of a mouse model of anxious depression to assess the safety of pediatric anti
    Bernhard Luscher; Fiscal Year: 2010
    ..stages corresponding to the last trimester of human development leads to behavior indicative of heightened anxiety and emotionality in adulthood...
  64. Anxiety Sensitivity, Menstrual Cycle Phase, and Panic-Relevant Responding
    Yael Nillni; Fiscal Year: 2011
    ..There is a prominent gender difference, favoring females over males, on anxiety sensitivity (AS;i.e...
    MARLENE WILSON; Fiscal Year: 2000
    ..Adapted From The Applicant's Abstract) The benzodiaepines (BZs) are widely prescribed for the treatment of anxiety-related disorders, although these compounds also have anticonvulsant, hypnotic, and sedative actions...
  66. 2/3 CBT for Anxiety Disorders in Autism: Adapting Treatment for Adolescents
    Eric A Storch; Fiscal Year: 2010
    ..Comorbid anxiety disorders affect as many as 80% of youth with ASD, causing substantial distress and impairment over and above ..
  67. 3/3 CBT for Anxiety Disorders in Autism: Adapting Treatment for Adolescents
    JILL EHRENREICH MAY; Fiscal Year: 2010
    ..Comorbid anxiety disorders affect as many as 80% of youth with ASD, causing substantial distress and impairment over and above ..
  68. Role of Amygdalar CRF Receptors in Regulating Anxiety
    Tammy Sajdyk; Fiscal Year: 2005
    ..The results of this proposal should lead not only to a broader knowledge of anxiety disorders, but also to the intellectual, analytical and technical skills needed to develop into a independent ..
  69. Risk Factors for Late Life Anxiety
    JOHN CALAMARI; Fiscal Year: 2006
    b>Anxiety disorders are common among older adults, yet there is little information on risk or protective factors...
  70. Interactive effects of ethanol and estrogen on brain vasopressin during puberty
    Toni R Pak; Fiscal Year: 2010
    Women who abuse alcohol are twice as likely to develop anxiety disorders compared with men, a phenomenon in which the underlying biological mechanisms are unknown...
  71. Comorbid Anxiety Disorders in Adolescents with Asthma
    Wayne Katon; Fiscal Year: 2006
    ..Results from prior studies have suggested an increased prevalence of panic disorder and other anxiety disorders in populations of children and adults with asthma...
  72. Therapy Specificity and Mediation in Family & Group CBT
    Wendy Silverman; Fiscal Year: 2006
    ..has now accumulated demonstrating the efficacy of Individual Child Cognitive Behavior Therapy for reducing anxiety disorders in children...
    Barbara Fuller; Fiscal Year: 1993
    ..termed chaotic variability, and to determine if this new nonlinear type of variability is altered by stress-anxiety, as suggested by a pilot study...
  74. Massage Therapy Effects on Cerebrospinal Fluid Neurochemistry
    Thomas Geracioti; Fiscal Year: 2009 and has been shown to have a variety of positive effects on well being, particularly the ability to reduce anxiety, improve mood, and lower blood pressure...
    Anantha Shekhar; Fiscal Year: 1993
    b>Anxiety disorders are the most prevalent psychiatric disorders and appear to be a heterogenous group of disorders. The neurobiology of anxiety disorders is still poorly understood...
  76. Individual differences in anxiety in females
    Mohamed Kabbaj; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The purpose of this application is to examine the effects of estradiol on anxiety like behaviors and the effects of estradiol on Limbic-Hypothalamo-Pituitary-Adrenal axis (LHPA) activity in female ..
  77. Anticipating reward & threat: A test of biobehavioral processes in MDD vs anxiety
    STEWART AARON SHANKMAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Depressive and anxiety disorders are each associated with significant impairment and disability and when they co-occur (which happens at alarmingly high rates) are especially harmful and difficult to ..