stereotyped behavior

Summary

Summary: Relatively invariant mode of behavior elicited or determined by a particular situation; may be verbal, postural, or expressive.

Top Publications

  1. ncbi Supersensitivity to amphetamine in protein kinase-C interacting protein/HINT1 knockout mice
    Elisabeth Barbier
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Neuropsychopharmacology 32:1774-82. 2007
  2. ncbi Recurrent perseveration correlates with abnormal repetitive locomotion in adult mink but is not reduced by environmental enrichment
    Jamie A Dallaire
    University of Guelph, Department of Animal and Poultry Science, 50 Stone Road East, Building 70, Guelph, Ontario N1G 2W1, Canada
    Behav Brain Res 224:213-22. 2011
  3. pmc Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism
    Loren A Martin
    Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, California National Primate Research Center and The MIND Institute, University of California Davis, 2825 50th Street, Sacramento, CA 95817, USA
    Brain Behav Immun 22:806-16. 2008
  4. ncbi The factor structure of autistic traits
    John N Constantino
    Washington University School of Medicine, Missouri 63110, USA
    J Child Psychol Psychiatry 45:719-26. 2004
  5. ncbi Environmentally enriched rearing environments reduce repetitive perseveration in caged mink, but increase spontaneous alternation
    Dana L M Campbell
    Department of Animal and Poultry Science, University of Guelph, 50 Stone Road East, Guelph, Ontario, Canada
    Behav Brain Res 239:177-87. 2013
  6. ncbi Abnormal repetitive behaviours: shared phenomenology and pathophysiology
    A M Muehlmann
    Department of Psychiatry, University of Florida, Gainesville, Florida, USA
    J Intellect Disabil Res 56:427-40. 2012
  7. ncbi Stress and stereotypic behaviour in mink (Mustela vison): a focus on adrenocortical activity
    J Malmkvist
    Department of Animal Health and Bioscience, Aarhus University, Blichers alle 20, DK 8830, Tjele, Denmark
    Stress 14:312-23. 2011
  8. pmc Olfactory mechanisms of stereotyped behavior: on the scent of specialized circuits
    Lisa Stowers
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Neurobiol 20:274-80. 2010
  9. ncbi Repetitive behaviors in monkeys are linked to specific striatal activation patterns
    Esen Saka
    Department of Neurology, Akdeniz University Hospital, 07059 Antalya, Turkey
    J Neurosci 24:7557-65. 2004
  10. pmc Dopamine receptor modulation of repetitive grooming actions in the rat: potential relevance for Tourette syndrome
    Jennifer L Taylor
    Department of Psychology, University of Michigan, Ann Arbor, MI48109 1043, USA
    Brain Res 1322:92-101. 2010

Research Grants

Detail Information

Publications235 found, 100 shown here

  1. ncbi Supersensitivity to amphetamine in protein kinase-C interacting protein/HINT1 knockout mice
    Elisabeth Barbier
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    Neuropsychopharmacology 32:1774-82. 2007
    ..These results demonstrate an important role of PKCI/HINT1 in modulating the behavioral response to AMPH. Furthermore, they indicate that the absence of this protein may be associated with dysregulation of postsynaptic DA transmission...
  2. ncbi Recurrent perseveration correlates with abnormal repetitive locomotion in adult mink but is not reduced by environmental enrichment
    Jamie A Dallaire
    University of Guelph, Department of Animal and Poultry Science, 50 Stone Road East, Building 70, Guelph, Ontario N1G 2W1, Canada
    Behav Brain Res 224:213-22. 2011
    ..Thus, the relationship between recurrent perseveration and ARB may only develop with age; longitudinal studies are now required for confirmation...
  3. pmc Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism
    Loren A Martin
    Department of Psychiatry and Behavioral Sciences, Center for Neuroscience, California National Primate Research Center and The MIND Institute, University of California Davis, 2825 50th Street, Sacramento, CA 95817, USA
    Brain Behav Immun 22:806-16. 2008
    ..This research raises the prospect of prenatal evaluation for neurodevelopmental risk factors and the potential for preventative therapeutics...
  4. ncbi The factor structure of autistic traits
    John N Constantino
    Washington University School of Medicine, Missouri 63110, USA
    J Child Psychol Psychiatry 45:719-26. 2004
    ..The identification of 'endophenotypes' of the autistic syndrome may be very useful for genetic and neurobiologic studies of autism, but only if they represent truly independent sub domains of the disorder...
  5. ncbi Environmentally enriched rearing environments reduce repetitive perseveration in caged mink, but increase spontaneous alternation
    Dana L M Campbell
    Department of Animal and Poultry Science, University of Guelph, 50 Stone Road East, Guelph, Ontario, Canada
    Behav Brain Res 239:177-87. 2013
    ....
  6. ncbi Abnormal repetitive behaviours: shared phenomenology and pathophysiology
    A M Muehlmann
    Department of Psychiatry, University of Florida, Gainesville, Florida, USA
    J Intellect Disabil Res 56:427-40. 2012
    ..Although an increased prevalence of SIB has been documented in specific genetic mutations, little is known about the neurobiological basis of SIB. This makes vulnerability assessment and pharmacological treatment incredibly challenging...
  7. ncbi Stress and stereotypic behaviour in mink (Mustela vison): a focus on adrenocortical activity
    J Malmkvist
    Department of Animal Health and Bioscience, Aarhus University, Blichers alle 20, DK 8830, Tjele, Denmark
    Stress 14:312-23. 2011
    ..Instead, we conclude that mink with a high level of stereotypic behaviour have a greater perception of stress, or increased sensitivity to stressors at the pituitary level...
  8. pmc Olfactory mechanisms of stereotyped behavior: on the scent of specialized circuits
    Lisa Stowers
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Neurobiol 20:274-80. 2010
    ..This review focuses on these non-VNO receptors and neurons, and evaluates their potential for mediating stereotyped olfactory behavior in mammals...
  9. ncbi Repetitive behaviors in monkeys are linked to specific striatal activation patterns
    Esen Saka
    Department of Neurology, Akdeniz University Hospital, 07059 Antalya, Turkey
    J Neurosci 24:7557-65. 2004
    ....
  10. pmc Dopamine receptor modulation of repetitive grooming actions in the rat: potential relevance for Tourette syndrome
    Jennifer L Taylor
    Department of Psychology, University of Michigan, Ann Arbor, MI48109 1043, USA
    Brain Res 1322:92-101. 2010
    ..Together, these results have implications for understanding how dopamine receptors facilitate particular stereotypies manifest in animal models of Tourette syndrome and obsessive compulsive disorder...
  11. pmc Animal models of restricted repetitive behavior in autism
    Mark H Lewis
    McKnight Brain Institute and Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
    Behav Brain Res 176:66-74. 2007
    ..As mutant mouse models continue to proliferate, there should be a number of promising genetic models to pursue...
  12. ncbi Increasing stereotypy in adult zebra finch song correlates with a declining rate of adult neurogenesis
    Carolyn L Pytte
    Department of Psychology, Queens College, Flushing, New York 11367, USA
    Dev Neurobiol 67:1699-720. 2007
    ..We propose that age-related changes in the stereotypy of syllable acoustic structure and HVC neuron addition are functionally related...
  13. ncbi Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
    A R Mohn
    Department of Medicine, University of North Carolina at Chapel Hill 27599 USA
    Cell 98:427-36. 1999
    ..These findings support a model in which reduced NMDA receptor activity results in schizophrenic-like behavior and reveals how pharmacological manipulation of monoaminergic pathways can affect this phenotype...
  14. ncbi Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism
    K Pierce
    Department of Neurosciences, School of Medicine, University of California, 8110 La Jolla Shores Drive, La Jolla, CA 92037, USA
    Biol Psychiatry 49:655-64. 2001
    ..Further, measures of rates of stereotyped behavior were significantly negatively correlated with area measures of cerebellar vermis lobules VI-VII and ..
  15. ncbi Physiological and behavioral consequences associated with short-term prevention of crib-biting in horses
    P McGreevy
    Department of Clinical Veterinary Science, University of Bristol, UK
    Physiol Behav 65:15-23. 1998
    ....
  16. ncbi Stereotypy in young children with autism and typically developing children
    Rebecca MacDonald
    New England Center for Children, 33 Turnpike Road, Southborough, MA 01772 2108, USA
    Res Dev Disabil 28:266-77. 2007
    ....
  17. ncbi Super-stereotypy I: enhancement of a complex movement sequence by systemic dopamine D1 agonists
    K C Berridge
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
    Synapse 37:194-204. 2000
    ..Thus, dopamine D1 receptor activation appears to contribute to a kind of sequential super-stereotypy in which a complex, stereotyped behavioral sequence is initiated more frequently and more often goes to completion...
  18. ncbi Anti-striatal antibodies in Tourette syndrome cause neuronal dysfunction
    J J Hallett
    Department of Pediatrics, Brown University School of Medicine and 111 Brewster Street, 02860, Pawtucket, RI, USA
    J Neuroimmunol 111:195-202. 2000
    ..These data support the hypothesis that binding of an anti-neuronal antibody from some children with TS induced striatal dysfunction and suggest a possible cause for the basal ganglia alterations observed in children with TS...
  19. pmc Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation
    E H Chartoff
    Graduate Program in Neurobiology and Behavior, Department of Medicine, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 98:10451-6. 2001
    ..These results indicate that activation of D1 receptors on a specific population of striatal neurons is required for the induction of stereotypy in DD mice...
  20. ncbi Impaired instrumental choice in crib-biting horses (Equus caballus)
    Matthew Parker
    School of Psychology, University of Southampton, Highfield, Southampton, Hampshire SO17 1BJ, UK
    Behav Brain Res 191:137-40. 2008
    ..This suggests an initial behavioural correlate for dorsomedial striatum dysregulation in the stereotypy phenotype...
  21. ncbi Effects of tangible and social reinforcers on skill acquisition, stereotyped behavior, and task engagement in three children with autism spectrum disorders
    Soyeon Kang
    The Meadows Center for Preventing Educational Risk, University of Texas at Austin, United States
    Res Dev Disabil 34:739-44. 2013
    ..g., stereotypy, repetitive behavior) with their preferred items given as reinforcers. Considering the stereotyped behavior is a core characteristic of ASD aimed to reduce, it is necessary to identify alternative reinforcers that ..
  22. ncbi Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice
    S Amos
    Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P M B 21, Garki, Abuja, Nigeria
    J Ethnopharmacol 97:53-7. 2005
    ..These results indicate the presence of psychoactive substances in the aqueous extract of the root bark of Nauclea latifolia...
  23. ncbi An animal model of Tourette's syndrome
    Jane R Taylor
    Child Study Center, Children s Clinical Research Center, School of Nursing, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Psychiatry 159:657-60. 2002
    ..An animal model was used to investigate an autoimmune etiology for some cases of Tourette's syndrome...
  24. ncbi Abnormal expression of dopamine and serotonin transporters associated with the pathophysiologic mechanism of Tourette syndrome
    Li Jijun
    Department of Integrated Chinese and Western Medicine on Pediatrics, Provincial Hospital affiliated to Shandong University, Jinan, Shandong 250021, China
    Neurol India 58:523-9. 2010
    ..It is also well known that dopamine and serotonin transporters (DAT and SERT) are monoamine neurotransmitter transporters, which participate in the metabolism of DA and 5-HT, respectively...
  25. ncbi The energetic costs of stereotyped behavior in the paper wasp, Polistes dominulus
    Susan A Weiner
    Department of Biology, Tufts University, Medford, MA 02155, USA
    Naturwissenschaften 96:297-302. 2009
    ..These data suggest that maintaining reproductive dominance is not very energetically expensive for the dominant and that the dominant foundress expends energy at a lower rate than the subordinate foundress...
  26. ncbi Circadian variation in ghrelin and certain stress hormones in crib-biting horses
    Karin Hemmann
    University of Helsinki, Faculty of Veterinary Medicine, Department of Equine and Small Animal Medicine, Koetilantie 7, P O Box 57, 00014 Helsinki, Finland
    Vet J 193:97-102. 2012
    ..Further research is therefore needed to determine the relationship between crib-biting and ghrelin concentration...
  27. ncbi OCD-Like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons
    K M Campbell
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 19:5044-53. 1999
    ..These results suggest that chronic potentiation of cortical and limbic D1+ neurons thought to induce glutamatergic output to the striatum causes behaviors reminiscent of those in human cortical-limbic-induced compulsive disorders...
  28. ncbi Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism
    Tomasz Schneider
    Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Neuropsychopharmacology 30:80-9. 2005
    ..Our results bring further support to validity of the proposed VPA animal model of autism, suggesting similarities between the observed pattern of behavioral alterations in VPA rats and features of disturbed behavior in autistic patients...
  29. ncbi Aberrant responses in social interaction of dopamine transporter knockout mice
    Ramona M Rodriguiz
    Department of Psychiatry, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC 27710, USA
    Behav Brain Res 148:185-98. 2004
    ..These data suggest that KO mice may serve as a useful animal model for understanding not only how DA dysfunction contributes to social abnormalities, but also how behavioral inflexibility distorts their social responses...
  30. pmc Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism
    Bryan H King
    Seattle Children s Hospital, University of Washington, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Arch Gen Psychiatry 66:583-90. 2009
    ..Selective serotonin reuptake inhibitors are widely prescribed for children with autism spectrum disorders...
  31. pmc Dopamine uptake inhibition is positively correlated with cocaine-induced stereotyped behavior
    Evgeny A Budygin
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157, United States
    Neurosci Lett 429:55-8. 2007
    ..on freely moving rats was used to determine whether a correlation exists between the increase in stereotyped behavior and dopamine (DA) uptake inhibition following cocaine (20 mg/kg, i.p.) administration...
  32. ncbi Environmental enrichment: effects on stereotyped behavior and dendritic morphology
    Cortney A Turner
    McKnight Brain Institute and Department of Psychiatry, University of Florida, Gainesville, FL 32601, USA
    Dev Psychobiol 43:20-7. 2003
    We evaluated whether environmental enrichment-related effects on the development of stereotyped behavior in deer mice were associated with alterations in dendritic morphology...
  33. pmc Repetitive and stereotyped behaviors in children with autism spectrum disorders in the second year of life
    Nola Watt
    Discipline of Speech Pathology and Audiology, School of Human and Community Development, University of the Witwatersrand, 1 Jan Smuts Avenue, Private Bag 3, Wits, Johannesburg, Gauteng, 2050, South Africa
    J Autism Dev Disord 38:1518-33. 2008
    ..RSB in the second year appear to be important for early identification and prediction of developmental outcomes...
  34. ncbi Environmental enrichment: effects on stereotyped behavior and neurotrophin levels
    Cortney A Turner
    Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Physiol Behav 80:259-66. 2003
    The present study evaluated whether environmental enrichment-related effects on the development of stereotyped behavior in deer mice were associated with alterations in neurotrophin levels...
  35. ncbi Procedural learning and cognitive flexibility in a mouse model of restricted, repetitive behaviour
    Yoko Tanimura
    McKnight Brain Institute, Department of Psychiatry and Psychology, University of Florida, Gainesville, FL, USA
    Behav Brain Res 189:250-6. 2008
    ..Our findings support the applicability of the deer mouse model of spontaneous stereotypy to a wider range of restricted, repetitive behaviour (e.g., insistence on sameness) typical of neurodevelopmental disorders...
  36. ncbi Examining the relationship between executive functions and restricted, repetitive symptoms of Autistic Disorder
    Brian R Lopez
    Center for Development and Disability, University of New Mexico, 2300 Menaul NE, Albuquerque, NM 87107, USA
    J Autism Dev Disord 35:445-60. 2005
    ..The implications for the executive function theory and how the theory predicts core symptoms of autism are discussed...
  37. ncbi Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome
    H A Jinnah
    Department of Neurosciences, School of Medicine, University of California, San Diego 92093 0634
    Behav Neurosci 105:1004-12. 1991
    ..This behavioral supersensitivity to amphetamine indicates the existence of an underlying subclinical abnormality of catecholaminergic systems in the brains of HPRT-deficient mice, analogous to findings in human Lesch-Nyhan patients...
  38. ncbi Language level and nonverbal social-communicative behaviors in autistic and language-delayed children
    C Lord
    Department of Psychiatry, University of Chicago, IL 60637, USA
    J Am Acad Child Adolesc Psychiatry 35:1542-50. 1996
    ..To explore the relationship of general expressive language delay to nonverbal social-communicative deficits and repetitive behaviors associated with autism in preschool children...
  39. ncbi Concurrent activation of dopamine D1 and D2 receptors is required to evoke neural and behavioral phenotypes of cocaine sensitization
    Christine Capper-Loup
    Department of Neurology, University Hospital, 3010 Bern, Switzerland
    J Neurosci 22:6218-27. 2002
    ....
  40. ncbi Stereotyped behavior in the ontogeny of rats
    L M Lepekhina
    I M Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg
    Bull Exp Biol Med 144:349-51. 2007
    The ontogenetic development of stereotyped behavior induced by activation of dopamine D1 and D2 receptors with apomorphine was studied in rat pups (1st month of life) and adult rats (2nd-12th months of life)...
  41. ncbi Restricted and repetitive behaviors in young children with autism spectrum disorders
    Jennifer Richler
    University of Michigan Autism and Communication Disorders Center, 1014 Church Street, Apt C4, Ann Arbor, MI, 48109, USA
    J Autism Dev Disord 37:73-85. 2007
    ..On average, children with ASD had more RSM behaviors. Behaviors that loaded on the IS factor were relatively uncommon and did not differ in prevalence or severity across groups...
  42. ncbi Apomorphine susceptibility and animal models for psychopathology: genes and environment
    Bart A Ellenbroek
    Department of Psychoneuropharmacology, HB Nijmegen, The Netherlands
    Behav Genet 32:349-61. 2002
    ..Because schizophrenia is also likely to result from an interaction between genetic and early stressful life events, the APO-SUS rat might represent a promising animal model for studying this severe mental disorder...
  43. ncbi Dose-dependent response of central dopaminergic systems to buspirone in mice
    S A Jadhav
    Department of Pharmacology, Krishna Institute of Medical Sciences, Karad 415110, India
    Indian J Exp Biol 46:704-14. 2008
    ..The results indicate that drugs which influence the activity of central serotonergic systems modulate the intensity of buspirone induced cage climbing behaviour and catalepsy...
  44. pmc mu-Opioid receptor knockout mice are insensitive to methamphetamine-induced behavioral sensitization
    Xine Shen
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4500, USA
    J Neurosci Res 88:2294-302. 2010
    ..Our study indicated that the mu-opioid system is involved in modulating the development of behavioral sensitization to METH. (c) 2010 Wiley-Liss, Inc...
  45. ncbi Do California ground squirrels (Spermophilus beecheyi) use ritualized syntactic cephalocaudal grooming as an agonistic signal?
    S N Bursten
    Department of Psychology, University of California, Davis, USA
    J Comp Psychol 114:281-90. 2000
    ....
  46. ncbi Striatal volume on magnetic resonance imaging and repetitive behaviors in autism
    Eric Hollander
    Department of Psychiatry, Mount Sinai School of Medicine, Annenberg Bldg, 1 Gustave L Levy Place, New York, NY 10029, USA
    Biol Psychiatry 58:226-32. 2005
    ....
  47. ncbi The relationship between executive functioning, central coherence, and repetitive behaviors in the high-functioning autism spectrum
    Mikle South
    University of Utah, USA
    Autism 11:437-51. 2007
    ..Further research on repetitive behaviors in autism may benefit from a focus on narrow behavioral and cognitive constructs rather than general categories...
  48. ncbi Environmental enrichment: effects on stereotyped behavior and regional neuronal metabolic activity
    Cortney A Turner
    Department of Psychiatry, P O Box 100256, University of Florida, Gainesville, FL 32601, USA
    Brain Res 938:15-21. 2002
    The present study evaluated whether environmental enrichment-related effects on the development of stereotyped behavior in deer mice were associated with alterations in neuronal metabolic activity...
  49. pmc Mice with chronic norepinephrine deficiency resemble amphetamine-sensitized animals
    David Weinshenker
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 99:13873-7. 2002
    ..We conclude that in contrast to acute alpha1AR blockade, chronic NE deficiency induces changes similar to sensitization, perhaps by altering DA-signaling pathways...
  50. ncbi Nervous habits and stereotyped behaviors in preschool children
    L G Foster
    Child and Adolescent Psychiatry, University of Maryland at Baltimore 21201 1549, USA
    J Am Acad Child Adolesc Psychiatry 37:711-7. 1998
    ..To examine the frequency, age trends, and situational correlates of nervous habits (e.g., nail-biting, thumb-sucking) and motor stereotyped behaviors (e.g., body-rocking) in typically developing preschool children...
  51. ncbi Punding in Parkinson's disease: its relation to the dopamine dysregulation syndrome
    Andrew H Evans
    Reta Lila Weston Institute of Neurological Studies, London, United Kingdom
    Mov Disord 19:397-405. 2004
    ..We believe that this is an underreported, socially disabling phenomenon that is commonly associated with the syndrome of dopamine dysregulation and is phenomenologically distinct from both obsessive-compulsive disorder and mania...
  52. ncbi Is the early development of girls with Rett disorder really normal?
    Christa Einspieler
    Section Developmental Physiology and Developmental Neurology, Institute of Physiology, Center for Physiological Medecine, Medical University of Graz, A 8010 Graz, Austria
    Pediatr Res 57:696-700. 2005
    ..Although not necessarily specific, the signs that we have observed will be of value in alerting clinicians to the possibility of the diagnosis at an early stage, when intervention is likely to be most effective...
  53. ncbi Testosterone implants alter the frequency range of zebra finch songs
    Jeffrey Cynx
    Department of Psychology, Vassar College, 124 Raymond Avenue, Poughkeepsie, NY 12604, USA
    Horm Behav 47:446-51. 2005
    ..The frequency change remained after the apparent effects of the testosterone implants ended. These data show that high levels of testosterone can lower the frequencies of elements in zebra finch songs...
  54. ncbi Obsessive-compulsive behaviors in parents of multiplex autism families
    Eric Hollander
    Department of Psychiatry and Seaver Autism Research Center, Box 1230, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Psychiatry Res 117:11-6. 2003
    ..Dichotomizing autistic probands by severity and type of repetitive behaviors (circumscribed interests and compulsive rituals) may yield more homogenous groups, which could be helpful in genetic linkage studies...
  55. ncbi Lesions of an avian basal ganglia circuit prevent context-dependent changes to song variability
    Mimi H Kao
    Keck Center for Integrative Neuroscience, Department of Physiology and Psychiatry, University of California, San Francisco, CA 94143 0444, USA
    J Neurophysiol 96:1441-55. 2006
    ..Our findings suggest that a key function of avian basal ganglia circuitry is to regulate vocal performance and plasticity by specifically modulating moment-by-moment variability in the structure of individual song elements...
  56. ncbi Transplantation of rat neural stem cells reduces stereotypic behaviors in rats after intrastriatal microinfusion of Tourette syndrome sera
    Xiumei Liu
    Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China
    Behav Brain Res 186:84-90. 2008
    ..Our results suggest that transplantation of NSCs intrastriatum may have therapeutic potential for TS...
  57. ncbi Differential neurochemical and behavioral adaptation to cocaine after response contingent and noncontingent exposure in the rat
    Daniele Lecca
    Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy
    Psychopharmacology (Berl) 191:653-67. 2007
    ..Repeated exposure to the same drugs results in behavioral and biochemical sensitization characterized by stereotyped activity and reduction of the shell/core DA response ratio...
  58. ncbi Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    Am J Psychiatry 162:1142-8. 2005
    ..The authors report on whether risperidone improves the core symptoms of autism, social and communication impairment and repetitive and stereotyped behavior.
  59. ncbi Study of crib-biting and gastric inflammation and ulceration in young horses
    C J Nicol
    Department of Clinical Veterinary Science, University of Bristol, Langford House, Bristol BS40 5DU
    Vet Rec 151:658-62. 2002
    ..The crib-biting behaviour declined in most of the foals, regardless of their diet, but tended to decline to a greater extent in the foals on the antacid diet...
  60. ncbi Super-stereotypy II: enhancement of a complex movement sequence by intraventricular dopamine D1 agonists
    K C Berridge
    Departments of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1109, USA
    Synapse 37:205-15. 2000
    ..Our results highlight a role for dopamine D1 receptors, probably within the basal ganglia, in the production of sequential super-stereotypy of complex behavioral patterns...
  61. ncbi Sensitization of amphetamine-induced stereotyped behaviors during the acute response: role of D1 and D2 dopamine receptors
    R Kuczenski
    Department of Psychiatry 0603, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Brain Res 822:164-74. 1999
    ..Because these changes are apparent during the amphetamine response, they may have important implications for the evolving behavioral alterations which result when stimulants are administered in a binge pattern of drug abuse...
  62. ncbi Intranigral injection of the H3 agonist immepip and systemic apomorphine elicit ipsilateral turning behaviour in naive rats, but reduce contralateral turning in hemiparkinsonian rats
    Martha Garcia-Ramirez
    Departamento de Fisiologia, Escuela Nacional de Ciencias Biologicas, IPN, Plan de Ayala y Carpio s n, Mexico, D F, Mexico
    Behav Brain Res 154:409-15. 2004
    ....
  63. ncbi Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinson's disease
    Takao Yasuhara
    Department of Neurological Surgery, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan
    Eur J Neurosci 19:1494-504. 2004
    ..Further, VEGF is likely to promote neuroprotection indirectly by activating the proliferation of glia and by promoting angiogenesis. Our results support a potential neuroprotective role for VEGF in the treatment of Parkinson's disease...
  64. ncbi Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release
    Houman Homayoun
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 29:1259-69. 2004
    ..By extension, these results suggest that pharmacological potentiation of mGlu5 receptors may ameliorate the cognitive and other behavioral abnormalities associated with NMDA receptor deficiency...
  65. ncbi Bilateral increase of perforated synapses after unilateral dopamine depletion
    Maria Rosa Avila-Costa
    Department of Neuroscience, National University of Mexico, Iztacala, Mexico
    Int J Neurosci 115:79-86. 2005
    ....
  66. ncbi Prenatal ethanol enhances rotational behavior to apomorphine in the 24-month-old rat offspring with small striatal lesion
    Vania C Gomide
    Laboratory of Neuroregeneration, Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 2415, 05508 900 Sao Paulo, Brazil
    Neurotoxicol Teratol 26:417-27. 2004
    ..The results suggest that ethanol exposure during gestation may alter the sensitivity of dopamine receptor in aged offsprings, which is augmented by even a small striatal lesion...
  67. ncbi Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats
    Thomas J Martin
    Department of Physiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Pain 113:376-85. 2005
    ..Differences in drug potency could reflect fundamental differences in outcome measures or in the surgical procedures themselves. These data support combination study of intrathecal morphine and ketorolac for postoperative pain...
  68. ncbi Uptake of 6-[18F]fluoro-L-dopa and [18F]CFT reflect nigral neuronal loss in a rat model of Parkinson's disease
    Sarita Forsback
    MediCity PET, Turku PET Centre, FIN 20520 Turku, Finland
    Synapse 51:119-27. 2004
    ..However, [(18)F]FDOPA showed a much higher unspecific uptake of radioactivity, due to extensive metabolism; therefore, this tracer was less sensitive than the transporter tracer [(18)F]CFT to detect these defects...
  69. ncbi Age-dependent effects of nicotine on locomotor activity and conditioned place preference in rats
    James D Belluzzi
    Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697 4625, USA
    Psychopharmacology (Berl) 174:389-95. 2004
    ..This adolescent initiation may be due to multiple factors, but little evidence is available regarding whether their brains are differentially sensitive to the addictive effects of nicotine during adolescence...
  70. ncbi Bilateral subthalamic nucleus lesion reverses L-dopa-induced motor fluctuations and facilitates dyskinetic movements in hemiparkinsonian rats
    Concepcio Marin
    Laboratori de Neurologia Experimental, Fundació Clínic Hospital Clínic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, 08036 Barcelona, Spain
    Synapse 51:140-50. 2004
    ....
  71. ncbi A comparison of dopaminergic cells from the human NTera2/D1 cell line transplanted into the hemiparkinsonian rat
    J D Newcomb
    Center for Excellence in Aging and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Life Sci 81:441-8. 2007
    ..Other strategies used in conjunction with hNT cell replacement are likely needed to enhance and maintain the dopamine expression in the grafted cells...
  72. ncbi Individual differences in cocaine- and amphetamine-induced activation of male Sprague-Dawley rats: contribution of the dopamine transporter
    Sophia K Briegleb
    Neuroscience Program, Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO, USA
    Neuropsychopharmacology 29:2168-79. 2004
    ..Together, these results suggest that a difference in expression of functional DATs on the cell surface contributes to the individual differences observed in COC-induced, but not AMPH-induced, behavioral activation of rats...
  73. ncbi Ginkgo biloba affords dose-dependent protection against 6-hydroxydopamine-induced parkinsonism in rats: neurobehavioural, neurochemical and immunohistochemical evidences
    Muzamil Ahmad
    Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar New Delhi, India
    J Neurochem 93:94-104. 2005
    ..Considering our behavioural studies, biochemical analysis, and immunohistochemical observation, we conclude that EGb can be used as a therapeutic approach to check the neuronal loss following parkinsonism...
  74. pmc Sex differences in (+)-amphetamine- and (+)-methamphetamine-induced behavioral response in male and female Sprague-Dawley rats
    Alessandra Milesi-Hallé
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Pharmacol Biochem Behav 86:140-9. 2007
    ..In summary, these studies showed female rats displayed greater and longer-lasting locomotor activity and more stereotypic behaviors, supporting earlier evidence of significant sexual dimorphism in pharmacokinetics...
  75. pmc The laterodorsal tegmentum contributes to behavioral sensitization to amphetamine
    C L Nelson
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, USA
    Neuroscience 146:41-9. 2007
    ..Both results suggest relatively greater excitability of the LDT-VTA-NAc pathway after repeated amphetamine treatment. Our results provide the first evidence that neuronal plasticity in the LDT contributes to behavioral sensitization...
  76. ncbi The differential effects of 5-HT(1A) receptor stimulation on dopamine receptor-mediated abnormal involuntary movements and rotations in the primed hemiparkinsonian rat
    Kristin B Dupre
    Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, 4400 Vestal Parkway East, Binghamton, NY 13902 6000, USA
    Brain Res 1158:135-43. 2007
    ....
  77. ncbi Differences in dopamine responsiveness to drugs of abuse in the nucleus accumbens shell and core of Lewis and Fischer 344 rats
    Cristina Cadoni
    CNR Institute of Neuroscience, Section of Cagliari, Cagliari, Italy
    J Neurochem 103:487-99. 2007
    ..0 mg/kg), to the highest dose of amphetamine (1.0 mg/kg) and to all doses of cocaine. These differences might be the basis for the different behavioral responses of these strains to drugs of abuse...
  78. ncbi Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism
    Karuppagounder S Senthilkumar
    Division of Cell Biology and Physiology, Laboratory of Clinical and Experimental Neuroscience, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata 700032, India
    Behav Brain Res 184:11-8. 2007
    ..This approach is useful in reducing the oral dose of drugs that are with severe systemic effects, and that develop tolerance...
  79. ncbi Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in rats
    Torbjörn U C Järbe
    Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA
    Behav Pharmacol 18:673-80. 2007
    ..e. AM356), these data indicate that the anandamide analog AM1346 may be more behaviorally similar to cannabinoids like Delta(9)-THC than to other anandamide-based molecules such as methanandamide...
  80. ncbi Methylphenidate sensitization is prevented by prefrontal cortex lesion
    Min J Lee
    Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, P O Box 20708, Houston, TX 77225, United States
    Brain Res Bull 76:131-40. 2008
    ..These results suggest that the PFC does not interfere with the acute effects of MPD on locomotor activity but is required for development of behavioral sensitization to MPD...
  81. ncbi Histamine H(3) receptor ligands modulate L-dopa-evoked behavioral responses and L-dopa derived extracellular dopamine in dopamine-denervated rat striatum
    Przemyslaw Nowak
    Department of Pharmacology, Medical University of Silesia, 41 808 Zabrze, Poland
    Neurotox Res 13:231-40. 2008
    ..of histamine H(3) ligands on L-DOPA evoked behavioral responses (locomotor activity, number of rearings, stereotyped behavior and motor coordination). Using HPLC/ED and in vivo microdialysis technique imetit (5 mg/kg, i.p...
  82. ncbi Compromised circadian function in Parkinson's disease: enucleation augments disease severity in the unilateral model
    Gregory L Willis
    The Bronowski Institute of Behavioural Neuroscience, Neurosciences Section, Coliban Medical Centre, 19 Jennings Street, Kyneton, Victoria 3444, Australia
    Behav Brain Res 193:37-47. 2008
    ....
  83. pmc Cocaine during adolescence enhances dopamine in response to a natural reinforcer
    Briony J Catlow
    Department of Psychology PCD 4118G, Cognitive and Neural Sciences, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA
    Neurotoxicol Teratol 29:57-65. 2007
    ..Therefore, cocaine exposure during adolescence results in long-term functional changes in the mesolimbic pathway. Future studies need to ascertain the underlying mechanisms and their potential role in cocaine addiction...
  84. pmc Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse
    Michael T Williams
    Division of Neurology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 3039, USA
    Neuropsychopharmacology 32:1404-20. 2007
    ..5-MEO-DIPT may have the potential to induce untoward effects in humans...
  85. ncbi Neurochemical and behavioural characterisation of alkoxyamphetamine derivatives in rats
    Cesar A Romero
    Programme of Molecular and Clinical Pharmacology, ICBM, Medical Faculty, University of Chile, Santiago, Chile
    Neurotox Res 10:11-22. 2006
    ..The present observations can enlighten the mechanisms of action of drugs showing a high risk for abuse among young populations...
  86. ncbi Dopamine depletion increases the power and coherence of beta-oscillations in the cerebral cortex and subthalamic nucleus of the awake rat
    Andrew Sharott
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Eur J Neurosci 21:1413-22. 2005
    ..These changes may be important in regulating movement...
  87. ncbi The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959
    Xuechu Zhen
    Department of Physiology Pharmacology, City University of New York Medical School, 138th Street and Convent Ave New York, NY 10031, USA
    Pharmacol Biochem Behav 80:597-601. 2005
    ....
  88. ncbi Histological, behavioural and neurochemical evaluation of medial forebrain bundle and striatal 6-OHDA lesions as rat models of Parkinson's disease
    Hong Yuan
    Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium
    J Neurosci Methods 144:35-45. 2005
    ..However, the partial denervation renders its quite suitable for mimicking early stage Parkinson's disease, and is thus suitable for testing possible neuroprotective and neurotrophic drugs...
  89. ncbi Behavioural effects of parafascicular thalamic lesions in an animal model of parkinsonism
    J M Henderson
    Department of Pharmacology, Institute for Biomedical Research, School of Medical Sciences, Bosch Building, University of Sydney, NSW 2006, Australia
    Behav Brain Res 162:222-32. 2005
    ..The thalamic zone common to all lesioned animals involved the posterior Pf. Our data suggests that the posterior CM-Pf may be involved in motivational responses and autonomic dysfunction in parkinsonian disorders...
  90. ncbi The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation
    Mahmoud M Iravani
    Neurodegenerative Disease Research Centre, GKT School of Biomedical Sciences, King s College, London, SE1 1UL, UK
    Eur J Neurosci 22:317-30. 2005
    ..This study shows that acute glial activation leading to dopaminergic neuron degeneration is an acute short-lasting response that does not itself perpetuate cell death or lead to prolonged microglial activation...
  91. ncbi Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats
    Véronique Sgambato-Faure
    INSERM U318, Laboratoire de Neurosciences Précliniques, CHU Pavillon B, Grenoble, France
    J Neuropathol Exp Neurol 64:936-47. 2005
    ....
  92. ncbi Synthesis and biological activity of picobenzide (3,5-dimethyl-N-(pyridin-4-ylmethyl)benzamide) analogues as potential antipsychotic agents
    Ana Gradillas
    Departamento de Químicas, Facultad de Farmacia, Universidad San Pablo CEU, Boadilla del Monte, Madrid Spain
    Arzneimittelforschung 55:725-9. 2005
    ..Two compounds showed a promising pharmacological profile in screening tests of antipsychotic activity, since they affected apomorphine-induced hyperactivity without significant effects on stereotypies...
  93. ncbi Serotonin 2A receptor antagonist treatment reduces dopamine D1 receptor-mediated rotational behavior but not L-DOPA-induced abnormal involuntary movements in the unilateral dopamine-depleted rat
    Jennifer L Taylor
    Cellular and Clinical Neurobiology Program, Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neuropharmacology 50:761-8. 2006
    ..The finding that M100907 suppresses rotations induced by D1, but not D2, agonists may provide a partial explanation for the lack of effect of a selective 5-HT2A antagonist on l-DOPA-induced AIMs behaviors...
  94. ncbi Attenuation by Nardostachys jatamansi of 6-hydroxydopamine-induced parkinsonism in rats: behavioral, neurochemical, and immunohistochemical studies
    Muzamil Ahmad
    Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard Hamdard University, Hamdard Nagar, New Delhi 110062, India
    Pharmacol Biochem Behav 83:150-60. 2006
    ..This study indicates that the extract of Jatamansi might be helpful in attenuating Parkinsonism...
  95. ncbi Behavioral and physiological effects of a single injection of rat interferon-alpha on male Sprague-Dawley rats: a long-term evaluation
    A C Kentner
    School of Psychology, University of Ottawa, 11 Marie Curie, Room 108, Ottawa, Canada K1N 6N5
    Brain Res 1095:96-106. 2006
    ..Cumulatively, these data suggest that a single IFN-alpha exposure may elicit long-term behavioral disruptions and that its consequences should be thoroughly investigated for its use in clinical populations...
  96. ncbi Behavioral and biochemical effects of amperozide and serotonin agents on nigrostriatal and mesolimbic dopamine systems
    Pu Yuan Chang
    Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Chin J Physiol 51:106-15. 2008
    ..Overall, we conclude that the modulatory role of amperozide on forebrain dopamine system requires not only 5-HT2/D2 antagonistic but also the blockade of dopamine transporter...
  97. ncbi Combined intrastriatal dopamine D1 and serotonin 5-HT2 receptor stimulation reveals a mechanism for hyperlocomotion in 6-hydroxydopamine-lesioned rats
    C Bishop
    Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Neuroscience 121:649-57. 2003
    ....
  98. ncbi Sex differences in cocaine-stimulated motor behavior: disparate effects of gonadectomy
    Q D Walker
    Department of Pharmacology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 25:118-30. 2001
    ..In summary, gonadectomy effects were sex and behavioral topography specific and indicate that activational effects of gonadal hormones partially mediate the robust sex differences in cocaine-stimulated open-field behavior...
  99. ncbi The effects of continuous 5-HT(3) receptor antagonist administration on the subsequent behavioral response to cocaine
    George R King
    Department of Psychology, Texas Christian University, Fort Worth, TX 76129, USA
    Eur J Pharmacol 449:253-9. 2002
    ..The results clearly indicate that central 5-HT(3) receptors are critical for the effects of chronic cocaine administration...
  100. ncbi Modifications of the behavioral profile of non-competitive NMDA receptor antagonists, memantine, amantadine and (+)MK-801 after chronic administration
    M B Hesselink
    Department of Pharmacological Research, Merz and Co, Frankfurt am Main, Germany
    Behav Pharmacol 10:85-98. 1999
    ..The anti-cataleptic activity of amantadine remained unaltered. However, differences between drugs and the two treatment regimens (i.e. repetitive versus continuous treatments) were apparent...
  101. ncbi Evaluation of the mGluR2/3 agonist LY379268 in rodent models of Parkinson's disease
    Tracey K Murray
    Lilly Research Centre, Eli Lilly and Co Ltd, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK
    Pharmacol Biochem Behav 73:455-66. 2002
    ..These data suggest that activation of Group II mGlu receptors can provide some protection in models of PD, while their role in providing functional improvement is less clear...

Research Grants62

  1. DOPAMINERGIC MODULATION OF THE STARTLE REFLEX
    Michael Davis; Fiscal Year: 2004
    ..ganglia to study the role of dopamine in the generation of motor behaviors, such as locomotor activity or stereotyped behavior. Motor reflexes also are modulated by dopamine and thus represent another important class of motor ..
  2. Psychoneuroimmunology of T Cell Activation
    Steve Zalcman; Fiscal Year: 2004
    ..transfer of TH1 cells into syngeneic recipients induces a rapid increase in the incidence and intensity of stereotyped behavior. This implies that TH1 cells influence neuronal activity in the mesostriatal system...
  3. Epidemiological Research on Autism in Jamaica
    Mohammad H Rahbar; Fiscal Year: 2010
    ..early childhood, characterized by impairments in social interaction and communication, and by repetitive, stereotyped behavior. Although the causes of ASD are unknown, the evidence suggests that the origins are likely the result of ..
  4. Epidemiological Research on Autism in Jamaica - Phase II
    Mohammad H Rahbar; Fiscal Year: 2013
    ..early childhood, characterized by impairments in social interaction and communication, and by repetitive, stereotyped behavior. Although the causes of ASD are unknown, the evidence suggests that the origins are likely the result of ..
  5. Characterization of pheromone binding proteins
    LISA T STOWERS; Fiscal Year: 2013
    ..The precise subsets of neurons that generate stereotyped behavior are unknown in any species...
  6. Frontostriatal Synaptic Dysfunction in a Model of Autism
    PATRICK ROTHWELL; Fiscal Year: 2013
    ..Preliminary data indicate these mice develop more automated and stereotyped behavior in a motor learning task, a phenotype that may represent a behavioral indicator, as it is also associated ..
  7. MOLECULAR PHYSIOLOGY OF THE EPITRACHEAL ENDOCRINE SYSTEM
    Michael Adams; Fiscal Year: 2001
    Insect development from larva to adult depends on the repeated shedding of old cuticle via a highly stereotyped behavior called ecdysis...
  8. The Impact of Pten Signaling on Neuronal Form and Function
    Bryan W Luikart; Fiscal Year: 2013
    ..characterized by inappropriate responses to social and sensory stimulation, restricted communication, and stereotyped behavior. Heterozygous mutations in the gene Pten (phosphatase and tensin homolog on chromosome 10) have been ..
  9. RISK FACTORS AND EARLY DEVELOPMENT OF SELF-INJURY
    Frank Symons; Fiscal Year: 2001
    It has long been assumed that early stereotyped behavior may function as a precursor to later self-injurious behavior in children with mental retardation and related developmental disabilities...
  10. REPETITIVE BEHAVIOR PATTERNS--DEVELOPMENT & NEUROBIOLOGY
    Mark Lewis; Fiscal Year: 1999
    ..Although studies using pharmacological models of stereotyped behavior have identified important brain mechanisms, little is known about the neurobiological basis or function of ..
  11. COCAINES EFFECTS ON MOVEMENT RELATED STRIATAL FIRING
    Mark West; Fiscal Year: 2000
    ..Diverse evidence implicates specifically the lateral striatum in stereotyped behavior (e.g., licking, head bobbing in rats) induced by high doses of stimulants...
  12. Environmental Enrichment and Stereotyped Behavior
    Cortney Turner; Fiscal Year: 2003
    ..Thus, the proposed studies will attempt to identify CNS changes associated with the environmental enrichment-related decrease in the development of stereotype behaviors in deer mice. ..
  13. GABAA RECEPTORS: DEVELOPMENTAL INFLUENCE ON BEHAVIOR
    TIMOTHY DELOREY; Fiscal Year: 2006
    ..These include attentional processing, social interactions, exploration and stereotyped behavior. Additionally, we will also examine the consequences of this developmental disruption on the morphology and ..
  14. Ethopharmacological Characterization of Reward Systems
    Robert Huber; Fiscal Year: 2006
    ..of crayfish include a relatively simple and accessible CNS organization, and sets of conspicuous, stereotyped behavior patterns amenable to effective quantitative analysis...
  15. ANALYSIS OF INTERNEURONS AND MOTONEURONS
    PETER GETTING; Fiscal Year: 1980
    ..In particular, we are investigating the neuronal control of escape swimming, a highly organized and stereotyped behavior. We have three major aims for this proposed project...
  16. AUTISM--BRAIN MORPHOMETRY AND COGNITIVE NEUROSCIENCE
    Martha Herbert; Fiscal Year: 2003
    ..syndrome characterized by impairments in social interactions and communication and by repetitive, stereotyped behavior. To date there is no clear and consistently replicated neuroanatomic correlate...
  17. Longitudinal MRI Study of Brain Development in Fragile X
    Joseph Piven; Fiscal Year: 2006
    ..g., enlarged caudate and stereotyped behavior and hyperactivity)...
  18. Fine-grained analysis of vocal learning
    TODD TROYER; Fiscal Year: 2003
    The combination of an ethologically important, stereotyped behavior and specialized anatomy make avian song learning an ideal system in which to study the neural basis of motor learning...
  19. Examining Contingency Control Deficits in Autism and MR
    Louis Hagopian; Fiscal Year: 2006
    ..Autism has been characterized by deficits in communication and social skills, and restricted, repetitive, and stereotyped behavior patterns...
  20. Dscam diversity and circuit formation in the Drosophila nervous system
    Benjamin Matthews; Fiscal Year: 2009
    ..Taking advantage of the dramatic effect of Dscam overexpression on a easily screened, stereotyped behavior, I propose to conduct a suppressor screen to identify genes involved in Dscam signaling and neural ..
  21. Analysis of sperm transfer behavior in C elegans
    Gary Schindelman; Fiscal Year: 2004
    ..To simplify the task I will be studying a stereotyped behavior in an invertebrate system with a small well-defined nervous system...
  22. BIOPHYSICAL STUDY OF ANTIPSYCHOTICS BEHAVIORAL EFFECTS
    Stephen Fowler; Fiscal Year: 2009
    ..The results will improve our understanding of the pharmacological basis of dopamine related behaviors and assist in the discovery of improved antipsychotic medications. ..
  23. Simulated Human Pharmacokinetics in Rat: Methylphenidate
    Ronald Kuczenski; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. MECHANISM OF ACTION OF DRUGS OF ABUSE--AMPHETAMINE
    Ronald Kuczenski; Fiscal Year: 2004
    ..The possibility of nonsynaptic release sites on nigrostriatal DA afferents will be assessed by labeling components of the release mechanism and then correlating them with the locations of dopamine receptors. ..
  25. FLUOXETINE IN PEDIATRIC BODY DYSMORPHIC DISORDER
    Eric Hollander; Fiscal Year: 2008
    ..Abstract Not Provided. ..
  26. RUPP-PI
    Christopher McDougle; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] ..
  27. Greater New York Autism Research Center of Excellence
    Joseph Buxbaum; Fiscal Year: 2007
    ..Core B: Clinical Core; Core C: Data Management and Statistics Core; Core D: Information Transfer Core. ..
  28. Training in Psychopharmacology and Outcomes Research
    Eric Hollander; Fiscal Year: 2008
    ..of Medicine of Medicine of Medicine of Medicine of Medicine of Medicine format shown below. Role on ..
  29. Novel Pharmacological Strategies in Autism
    Christopher McDougle; Fiscal Year: 2009
    ..Phase II (following 6 months of aripiprazole monotherapy). ..
  30. SENSITIZATION AND CONDITIONING WITH ETHANOL
    KENT BERRIDGE; Fiscal Year: 2006
    ..abstract_text> ..
  31. PHARMACOTHERAPY OF ADOLESCENT BODY DYSMORPHIC DISORDER
    Eric Hollander; Fiscal Year: 2002
    ..When untreated, adolescent-onset BDD appears to often interfere with the developmental tasks of adolescence, to persist, and to cause substantial morbidity through out the life span. ..
  32. Divalproex Sodium/Placebo In Child/Adolesent Autism
    Eric Hollander; Fiscal Year: 2003
    ....
  33. Effects of Stress on Pathology of Parkinson's Disease
    GERLINDE METZ; Fiscal Year: 2004
    ..These approaches will provide the opportunity to understand factors involved in the pathology of PD and to develop novel therapeutic strategies for neurodegenerative motor disorders. ..
  34. Monoamine Transporters and Nonhman Primate Cocaine Use
    HEATHER KIMMEL; Fiscal Year: 2006
    ..The training experiences described will provide for the candidate's transition from a mentored scientist to an independent investigator. [unreadable] [unreadable] [unreadable] [unreadable]..
  35. NEUROIMAGING/DEVELOPMENTAL NEUROBIOLOGY OF AUTISM
    Antonio Hardan; Fiscal Year: 2005
    ..Course work and directed reading in biostatistcs, data management, research ethics, neuroanatorny, neuroimaging and developmental neuroscience will complement the research training. ..
  36. Primate Models of Autism
    MELISSA DAWN contact BAUMAN; Fiscal Year: 2010
    ....
  37. MODERATE LEVEL PRENATAL ALCOHOL EXPOSURE IN PRIMATES
    Mary L Schneider; Fiscal Year: 2010
    ....
  38. Dopaminergic Influences on Brain Formation and Function
    GREGG STANWOOD; Fiscal Year: 2006
    ..abstract_text> ..
  39. Mouse Model Of Autistic Repetitive Behavior
    Joseph Garner; Fiscal Year: 2003
    ..Developing a model of these symptoms in mice opens up several exciting new avenues for future research into environmental factors, genetic factors, and possible therapies. ..
  40. NEUROBIOLOGY AND GENETICS OF AUTISM
    Geraldine Dawson; Fiscal Year: 2006
    ..Thus, findings from all five research projects are being integrated in a synergistic way to offer a deeper understanding of the neurobiological and genetic basis of autism. ..
  41. Cannabinoid-Altered Vocal Development
    KENNETH M SODERSTROM; Fiscal Year: 2010
    ....
  42. Amphetamine Sensitization: Role of Dopamine Transporters
    JOSHUA GULLEY; Fiscal Year: 2003
    ..These experiments will help elucidate the role of the DAT in behavioral sensitization and further our understanding of the neuroadaptations associated with repeated drug intake. ..
  43. SOCIAL COGNITION AND AGING
    Thomas Hess; Fiscal Year: 2008
    ..abstract_text> ..
  44. NEUROANATOMY AND PHARMACOTHERAPY OF OCD AND MAJOR DEPRES
    Sanjaya Saxena; Fiscal Year: 2003
    ..abstract_text> ..
  45. Cannabinoid Effects on Development of a Learned Behavior
    KENNETH SODERSTROM; Fiscal Year: 2004
    ..Results will also expand knowledge of potential specific effects of cannabinoid exposure on development of a learned behavior. ..
  46. College Sports, Gender and Substance Use
    Kathleen Miller; Fiscal Year: 2006
    ..The research has the overall aim of establishing more effective prevention and intervention strategies for reducing young adult substance use and other related health-risk behaviors. ..
  47. Protective Cognitive Phenotypes in Costa Rica
    Jeremy Silverman; Fiscal Year: 2005
    ..Ultimately, a greatly enlarged longitudinal/genetic study using this population will identify new phenotypes for molecular genetic studies aimed at identifying genes with genetic protective variants. ..
  48. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Jeremy Silverman; Fiscal Year: 2006
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  49. Nornicotine for Treatment of Pain
    JOSEPH HOLTMAN; Fiscal Year: 2007
    ..This research project focuses on the development of a novel analgesic agent, nornicotine, for pain management. [unreadable] [unreadable] [unreadable]..
  50. MECHANISMS OF CANNABINOID'S ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2007
    ..The results will have important implications for the therapeutic utility of these "agonist antiemetics". [unreadable] [unreadable]..
  51. Serotonergic Regulation of Behavioral Disinhibition
    Stephen Bonasera; Fiscal Year: 2007
    ..abstract_text> ..
  52. Neurobiology of Obsessive-Compulsive Hoarding
    Sanjaya Saxena; Fiscal Year: 2007
    ..The long-term goal is to develop more effective treatments for compulsive hoarding, based on an improved understanding of its pathophysiology. ..
  53. ASCORBATE AS EXTRACELLULAR NEUROMODULATOR IN NEOSTRIATUM
    GEORGE REBEC; Fiscal Year: 2008
    ..Collectively, these approaches are designed to assess how fluctuations in striatal ascorbate and glutamate contribute to the neuronal malfunctions underlying the motor phenotype of HD. [unreadable] [unreadable]..
  54. Role of Visual Cues in Stereotyping
    IRENE BLAIR; Fiscal Year: 2002
    ..The proposed research will advance our understanding of the extent to which feature-based stereotypes may contributed to such disparities. ..
  55. Effect of Lead, Manganese and Stress During Development
    Michael T Williams; Fiscal Year: 2010
    ..Potential mechanisms will be explored by investigating neurotransmitter and neuroendocrine systems and the glutamate receptor complex. ..