Genomes and Genes
Summary: The interference with or prevention of a behavioral or verbal response even though the stimulus for that response is present; in psychoanalysis the unconscious restraining of an instinctual process.
Publications715 found, 100 shown here
- A role for endogenous histamine in interleukin-8-induced neutrophil infiltration into mouse air-pouch: investigation of the modulatory action of systemic and local dexamethasoneM Perretti
Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of Saint Bartholomew s Hospital, London
Br J Pharmacol 112:801-8. 1994..The anti-inflammatory action of the glucocorticoids, as in some other models, appears to be LCl-dependent when these drugs are given systemically and LCl independent when the steroids are given locally...
- Effects of high calcium diet on arterial smooth muscle function and electrolyte balance in mineralocorticoid-salt hypertensive ratsP Arvola
Department of Biomedical Sciences, University of Tampere, Finland
Br J Pharmacol 108:948-58. 1993....
- Non-adrenergic, non-cholinergic relaxation of the bovine retractor penis muscle: role of S-nitrosothiolsX Liu
Department of Pharmacology, University of Glasgow
Br J Pharmacol 111:1287-95. 1994..The effects of pyrogallol and hydroquinone suggest that the NANCneurotransmitter is a superoxide anion-resistant, nitric oxide-releasing molecule and that neither S-nitrocysteine nor S-nitrosoglutathione is a suitable candidate for this...
- Vascular responses to endothelin-1 following inhibition of nitric oxide synthesis in the conscious ratJ G Filep
Research Center, Maisonneuve Rosemont Hospital, , Canada
Br J Pharmacol 110:1213-21. 1993..These findings confirm the role of NO in the maintenance of blood pressure and suggest an important role for NO in the regulation of microvascular permeability...
- Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenaseR M McMillan
ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire
Br J Pharmacol 107:1042-7. 1992..v. Zileuton was approximately 10 times less potent.9. In view of the pharmacological profile described here, ICI D2138 has the potential to provide improved clinical efficacy compared to existing lipoxygenase inhibitors such as zileuton...
- Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagoguesG Panagiotidis
Department of Pharmacology, University of Lund, Sweden
Br J Pharmacol 114:289-96. 1995..8. Taken together with previous data the present results suggest that islet production of low physiological levels of free radicals such as NO and H202 may serve as important modulators of insulin secretory processes...
- Inhibition by SR 140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent vasodilatation in the hamster cheek pouch microvasculature in vivoJ M Hall
Biomedical Sciences Division, King s College London
Br J Pharmacol 113:522-6. 1994..Keywords: Cheek pouch (hamster); substance P; neurokinin; tachykinin; NK1-receptor; nitric oxide; microvasculature;SR140333; L-NAME; vasodilatation..
- Mechanistic data and risk assessment of selected toxic end points of the thyroid glandC C Capen
Department of Veterinary Biosciences, Ohio State University, Columbus 43210, USA
Toxicol Pathol 25:39-48. 1997....
- Phosphorylation- and voltage-dependent inhibition of neuronal calcium currents by activation of human D2(short) dopamine receptorsN A Brown
Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Terlings Park, Harlow, Essex
Br J Pharmacol 115:459-66. 1995....
- Antiproliferative effects of A02011-1, an adenylyl cyclase activator, in cultured vascular smooth muscle cells of ratS M Yu
Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
Br J Pharmacol 114:1227-35. 1995..A02011-1 did not cause cell toxicity and may thus hold promising potential for the prevention of atherosclerosis or vascular diseases...
- Interdependence of contractile responses of rat small mesenteric arteries on nitric oxide and cyclo-oxygenase and lipoxygenase products of arachidonic acidX C Wu
Department of Physiology, University of Birmingham, Edgbaston
Br J Pharmacol 112:360-8. 1994....
- Nitric oxide synthase inhibition by N(omega)-nitro-L-arginine methyl ester modulates G-protein expression and adenylyl cyclase activity in rat heartF Di Fusco
Department of Physiology and Groupe de Recherche sur le Systeme Nerveux Autonome, Universite de Montreal, Quebec, Canada
Am J Hypertens 10:471-5. 1997..These results suggest that the altered expression of Gi alpha proteins and adenylyl cyclase activity in L-NAME-treated rats may be attributed to hypertension and not to hypertrophy...
- Modulation by nicotinamide adenine dinucleotide of sympathetic and sensory-motor neurotransmission via P1-purinoceptors in the rat mesenteric arterial bedV Ralevic
Department of Anatomy and Developmental Biology, University College London
Br J Pharmacol 114:1541-8. 1995....
- Bradykinin-stimulated phosphoinositide metabolism in cultured canine tracheal smooth muscle cellsC M Yang
Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
Br J Pharmacol 111:21-8. 1994..The transduction mechanism of BK coupled to PI hydrolysis is sensitive to feedback regulation by PKC...
- Comparison of effects of chronic and acute administration of NG-nitro-L-arginine methyl ester to the rat on inhibition of nitric oxide-mediated responsesC E Bryant
William Harvey Research Institute, Medical College of Saint Bartholomew s Hospital, London
Br J Pharmacol 114:1673-9. 1995..The resistance of peripheral neuronal NO responses to chronic treatment with L-NAME indicates that selective inhibition of different isoforms of NOS may be achieved in vivo...
- Relative roles of nitric oxide and cyclo-oxygenase and lipoxygenase products of arachidonic acid in the contractile responses of rat renal arcuate arteriesX C Wu
Department of Physiology, University of Birmingham, Edgbaston
Br J Pharmacol 112:369-76. 1994..A cyclooxygenase product which appears to be endothelium-independent and the other an endothelium dependent lipoxygenase product...
- Effect of inhibition of nitric oxide synthesis on the uptake of LDL and fibrinogen by arterial walls and other organs of the ratL E Cardona Sanclemente
Pathopharmacology Unit, William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
Br J Pharmacol 114:1490-4. 1995....
- Inhibition by dizocilpine (MK-801) of striatal dopamine release induced by MPTP and MPP+: possible action at the dopamine transporterP B Clarke
Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada
Br J Pharmacol 114:315-22. 1995..MPTP and MPP+ also appear to interact with brain nicotinic cholinoceptors but the functional consequences of this interaction are not yet clear...
- Calcium antagonist and antiperoxidant properties of some hindered phenolsG P Sgaragli
Istituto di Scienze Farmacologiche, Siena, Italy
Br J Pharmacol 110:369-77. 1993..8. Di-t-BHA is proposed as a lead reference compound for future synthesis of new antioxidants combining two potentially useful properties in the prevention of tissue damage after ischaemia reperfusion injury...
- [Hemodynamic effects of sub-chronic NO synthase inhibition in conscious dogs: role of EDRF/NO in muscular exertion]L Puybasset
Arch Mal Coeur Vaiss 88:1217-21. 1995..In addition, L-NNA blunts both exercise-induced peripheral vasodilation and increase in cardiac output, despite metabolic vasodilation...
- Effects of omega-conotoxin on adrenergic, cholinergic and NANC neurotransmission in the rabbit urethra and detrusorP M Zygmunt
Department of Clinical Pharmacology, University of Lund, Sweden
Br J Pharmacol 110:1285-90. 1993..This raises the question whether VOCCs of a type other than L, T, and N is involved in the mediation of this response...
- Selective inhibition by barbiturates of the synthesis of endothelium-derived hyperpolarizing factor in the rabbit carotid arteryV Lischke
Centre of Physiology, Johann Wolfgang Goethe University Clinic, Frankfurt am Main, Germany
Br J Pharmacol 115:969-74. 1995....
- Selective inhibition of E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 expression by inhibitors of I kappa B-alpha phosphorylationC C Chen
Upjohn Laboratories, Kalamazoo, MI 49001, USA
J Immunol 155:3538-45. 1995..Pharmacologic inhibition of I kappa B-alpha proteolysis represents a novel approach to the development of anti-inflammatory therapeutics...
- Immediate inhibitory effect of methylprednisolone suleptanate (U-67590A) on antigen-induced cutaneous and airway anaphylactic responses in guinea-pigsM Hashimoto
Department of Pharmacology, Tsukuba Research Laboratories, Upjohn Pharmaceuticals Limited, Ibaraki, Japan
Br J Pharmacol 108:604-12. 1993..The latter share common inhibitory actions with other glucocorticoids which are dependent on protein synthesis through gene expression...
- Inhibitors of Na-K-ATPase in human urine: effects of ouabain-like factors and of vanadium-diascorbate on calcium mobilization in rat vascular smooth muscle cells: comparison with the effects of ouabain, angiotensin II, and arginine-vasopressinH Meyer-Lehnert
Renal Section, Medical Policlinic, University of Bonn, Germany
Am J Hypertens 13:364-9. 2000..The physiologic and pathologic roles of these and additional OLF in body fluid and blood pressure regulation and in hypertension have yet to be evaluated...
- Ionotropic glutamate receptor types leading to adenosine-mediated inhibition of electrically evoked [3H]-noradrenaline release in rabbit brain cortex slicesI von Kugelgen
Pharmakologisches Institut, Freiburg, Germany
Br J Pharmacol 110:1544-50. 1993....
- Ca(2+)-dependent and -independent mechanism of cyclic-AMP reduction: mediation by bradykinin B2 receptorsH Sipma
Groningen Institute for Drugs Studies GIDS, Department of Clinical Pharmacology, University of Groningen, The Netherlands
Br J Pharmacol 115:937-44. 1995..The increase in [Ca2+], mediated by bradykinin B2 receptors inhibited forskolin- and isoprenaline-activated adenylyl cyclase differently, most likely by interfering with different components of the adenylyl cyclase signalling pathway...
- Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2E C Landucci
Department of Biochemistry, UNICAMP, Campinas SP, Brazil
Br J Pharmacol 114:578-83. 1995..It is possible that crotapotin may interact with extracellular PLA2 generated during the inflammatory process thereby reducing its hydrolytic activity...
- GABA-mediated inhibition of the anaphylactic response in the guinea-pig tracheaG Gentilini
Department of Preclinical and Clinical Pharmacology Mario Aiazzi Mancini, University of Florence, Italy
Br J Pharmacol 115:389-94. 1995..An involvement of neuropeptidergic sensory structures is suggested but a role for epithelial cells and arachidonate metabolites is not definitely proved...
- Effect of cromakalim and glibenclamide on spontaneous and evoked motility of the guinea-pig isolated renal pelvis and ureterC A Maggi
Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
Br J Pharmacol 111:687-94. 1994..Glibenclamide-sensitive K channels take part in determining action potential shape and duration in the guinea-pig ureter...
- Antihypertensive agents prevent nephrosclerosis and left ventricular hypertrophy induced in rats by prolonged inhibition of nitric oxide synthesisN Akuzawa
Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
Am J Hypertens 11:697-707. 1998....
- Effect of chronic angiotensin II inhibition on the cardiovascular system of the normal ratL Gonzalez Bosc
Cátedra de Biología Celular e Histología, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
Am J Hypertens 13:1301-7. 2000..On the other hand, renin-angiotensin system inhibition induces a protective effect on the heart and aorta through structural and functional changes. Most of this action seems to be exerted through angiotensin II type 1 receptors...
- Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expressionP A Lochhead
Division of Cell Signalling, School of Life Sciences, University of Dundee, UK
Diabetes 50:937-46. 2001..These findings indicate that GSK-3 inhibitors may have greater therapeutic potential for lowering blood glucose levels and treating type 2 diabetes than previously realized...
- 'Sensory-efferent' neural control of mucus secretion: characterization using tachykinin receptor antagonists in ferret trachea in vitroS I Ramnarine
Department of Thoracic Medicine, National Heart and Lung Institute, London
Br J Pharmacol 113:1183-90. 1994..Potent and selective tachykinin antagonists may have therapeutic potential in bronchial diseases such as asthma and chronic bronchitis in which neurogenic mucus hypersecretion may be aetiologically important...
- Modulation of 5-HT release in the guinea-pig brain following long-term administration of antidepressant drugsP Blier
Department of Psychiatry, McGill University, , , Canada
Br J Pharmacol 113:485-95. 1994..Keywords: 5-HT reuptake blockade; monoamine oxidase inhibition; 5-HT autoreceptor; alpha 2-adrenoceptors; 5-HT3 receptors;[3H]-5-HT release; [3H]-noradrenaline release..
- Role of prostaglandins and nitric oxide in acute inflammatory reactions in guinea-pig skinM M Teixeira
Department of Applied Pharmacology, National Heart and Lung Institute, London
Br J Pharmacol 110:1515-21. 1993..Since administration of L-NAME also causes a local decrease in basal blood flow, we suggest that this is the mechanism by which it exerts anti-inflammatory effects in this model...
- Reversal of the suppressed kidney renin level in the hypertensive transgenic rat TGR(mRen-2)27 by angiotensin converting enzyme inhibitionY Tokita
Department of Medicine, Medical College of Ohio, Toledo, USA
Am J Hypertens 8:1031-9. 1995..The low kidney renin appears to be due to physiological rather than genetic factors...
- Characterization of receptors mediating vascular responses to endothelin-1 in the conscious ratJ G Filep
Research Center, Maisonneuve Rosemont Hospital, , Canada
Br J Pharmacol 113:845-52. 1994....
- [Inhibition of biofilm formation by clarithromycin (CAM) in an experimental model of complicated bladder infection--in vitro study using automated simulation of urinary antimicrobial concentration]M Sano
Department of Urology, Sapporo Medical University, School of Medicine
Kansenshogaku Zasshi 68:1306-17. 1994..aeruginosa biofilm, was measured per 5 glass beads on Day 3, 5, and 7 after starting drug administration. The alginate content increased with time when CPFX was given alone at a dose of 200 mg t.i.d..(ABSTRACT TRUNCATED AT 400 WORDS)..
- Inhibition by N-acetyl-5-hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized ratP Klemm
William Harvey Research Institute, St Bartholomew s Hospital Medical College, Charterhouse Square, London
Br J Pharmacol 115:1175-81. 1995..This mechanism may also account for the beneficial haemodynamic effect of NAS in our experimental model of endotoxaemia...
- Muscarinic excitatory and inhibitory mechanisms involved in afferent fibre-evoked depolarization of motoneurones in the neonatal rat spinal cordT Kurihara
Department of Pharmacology, Faculty of Medicine, Tokyo Medical and Dental University, Japan
Br J Pharmacol 110:61-70. 1993..8. The present study suggests that both excitatory (via M3-type receptors) and inhibitory (via M2-type receptors) muscarinic mechanisms are involved in afferent fibre-evoked nociceptive transmissions in the neonatal rat spinal cord...
- Release of hydrogen peroxide by rat type II pneumocytes in the prolonged cultureW J Piotrowski
Department of Pneumology and Allergology, Medical University of Lodz, Kopcinkiego 22, 90-153, Lodz, Poland
Toxicol In Vitro 14:85-93. 2000..Both mitochondrial respiratory chain and membrane-bound NADPH-oxidase may be responsible for the production of H(2)O(2) by T II pneumocytes...
- Inhibition of nitric oxide synthesis reveals non-cholinergic excitatory neurotransmission in the canine proximal colonC W Shuttleworth
Department of Physiology, University of Nevada School of Medicine, Reno 89557
Br J Pharmacol 109:739-47. 1993....
- Involvement of pertussis toxin-sensitive and -insensitive mechanisms in alpha-adrenoceptor modulation of noradrenaline release from rat sympathetic neurones in tissue cultureC E Hill
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra
Br J Pharmacol 110:281-8. 1993..The data suggest further that in this preparation the mechanism of alpha2-adrenoceptor modulation may involve pertussis toxin sensitive and insensitive G-proteins and effects on calcium channels other than L-type...
- Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamilM D Randall
Department of Diagnostic Radiology, University of Wales College of Medicine, Health Park, Cardiff
Br J Pharmacol 109:386-93. 1993..These results suggest that levcromakalim may selectively dilate both hypoxic vessels and vessels with impaired EDRF activity. The results also point to important differences in the pharmacology of levcromakalim and pinacidil...
- Evidence for differential roles of nitric oxide (NO) and hyperpolarization in endothelium-dependent relaxation of pig isolated coronary arteryE V Kilpatrick
Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia
Br J Pharmacol 112:557-65. 1994....
- Bradykinin B1 receptors in the rabbit urinary bladder: induction of responses, smooth muscle contraction, and phosphatidylinositol hydrolysisS K Butt
Biomedical Sciences Division, King s College London, Chelsea
Br J Pharmacol 114:612-7. 1995..We demonstrate, for the first time, B1 receptor-coupling to phosphatidylinositol hydrolysis in an intact tissue preparation...
- Inhibition by KF17837 of adenosine A2A receptor-mediated modulation of striatal GABA and ACh releaseM Kurokawa
Department of Pharmacology, University of Cambridge
Br J Pharmacol 113:43-8. 1994..Keywords: Acetylcholine release; GABA release; CGS 21680; A2A adenosine receptor; rat striatum; globus pallidus; KF17837..
- Evidence for P2-purinoceptor-mediated inhibition of noradrenaline release in rat brain cortexI von Kugelgen
Pharmakologisches Institut, Freiburg, Germany
Br J Pharmacol 113:815-22. 1994..Inconsistencies in antagonist effects against nucleotides are probably due to this activation of two receptors. The presynaptic P2-purinoceptor is P2Y-like, as it is in the peripheral sympathetic nervous system...
- Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental areaB Bowery
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex
Br J Pharmacol 112:873-80. 1994....
- Muscarinic (M1) receptor-mediated inhibition of K(+)-evoked [3H]-noradrenaline release from human neuroblastoma (SH-SY5Y) cells via inhibition of L- and N-type Ca2+ channelsR L McDonald
Department of Pharmacology, University of Leeds
Br J Pharmacol 113:621-7. 1994..Keywords: SH-SY5Y; calcium channels; noradrenaline release; muscarinic receptor; nifedipine; w-conotoxin GVIA; pirenzepine;hexahydrosiladiphenidol..
- Role of fructose 2,6-bisphosphate in the control of glycolysis. Stimulation of glycogen synthesis by lactate in the isolated working rat heartC Depre
Hormone and Metabolic Research Unit, University of Louvain Medical School, Brussels, Belgium
Acta Cardiol 48:147-64. 1993..The latter also controls glucose metabolism by diverting glucose from glycolysis to glycogen synthesis...
- Time course of inhibition of hypertension by antisense oligonucleotides targeted to AT1 angiotensin receptor mRNA in spontaneously hypertensive ratsR Gyurko
Department of Physiology, College of Medicine, University of Florida, Gainesville 32610, USA
Am J Hypertens 10:56S-62S. 1997..The mechanism for the long action of a single AS-ODN injection is hypothesized as resulting from the persistence of AS-ODN in the nucleus, preventing transport of the mRNA into the cytoplasm...
- Inhibition of interleukin 2 driven proliferation of mouse CTLL2 cells, by selected carbamate and organophosphate insecticides and congeners of carbarylG P Casale
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha 68198-6025
Immunopharmacol Immunotoxicol 15:199-215. 1993....
- Inhibition of rat colon contractility by prostacyclin (IP-) receptor agonists: involvement of NANC neurotransmissionY M Qian
Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT
Br J Pharmacol 115:163-71. 1995..The second transmitter mechanism is apamin-sensitive; the experimental results do not support ATP, adenosine or VIP as transmitter candidates. However, further studies using more potent and selective receptor antagonists are required...
- Regulation of vascular and gastric smooth muscle contractility by pervanadateA Laniyonu
Department of Pharmacology and Therapeutics, University of Calgary, Faculty of Medicine, AB, Canada
Br J Pharmacol 113:403-10. 1994..Keywords: Rat aorta; gastric smooth muscle; pervanadate; vanadate; tyrosine kinase; tyrosine phosphatase..
- MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptidesJoseph D Raffetto
Division of Vascular Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Surg Res 159:755-64. 2010..We tested whether MMP-2 induced venous relaxation involves inhibition of the Ca(2+) mobilization mechanisms of VSM contraction due to generation of Arg-Gly-Asp (RGD)-containing peptides...
- Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptorJ K Ward
Department of Thoracic Medicine, National Heart and Lung Institute, London
Br J Pharmacol 111:1095-102. 1994..These data suggest that an atypical 5-HT receptor inhibits the release of neuropeptides from sensory C fibres and may act as other inhibitory neuromodulators via the opening of a common K'channel...
- Modulation by stereoselective inhibition of cyclo-oxygenase of electromechanical coupling in the guinea-pig isolated renal pelvisP Santicioli
Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
Br J Pharmacol 114:1149-58. 1995..Previous reports of a total suppression of pyeloureteral motility by indomethacin may reflect a combination of COX inhibition and nonspecific effect on electromechanical coupling...
- Effects of dipeptidyl peptidase iv inhibition on arterial blood pressureEdwin K Jackson
Center for Clinical Pharmacology, Department of Pharmacology, University of Pittsburgh School of Medicine, 100 Technology Drive, Suite 450, Pittsburgh, PA 15219 3130, USA
Clin Exp Pharmacol Physiol 35:29-34. 2008..The results suggest vigilance because DPP IV inhibitors are used more widely in hypertensive patients treated with antihypertensive drugs...
- [Inhibitory activity of blood group antigens M and N in inhibition of virus hemagglutination reactions of influenza viruses]S Vojvodic
Zavod za transfuziju krvi, Novi Sad
Med Pregl 53:7-14. 2000....
- Adrenocorticotropic hormone and cAMP inhibit noninactivating K+ current in adrenocortical cells by an A-kinase-independent mechanism requiring ATP hydrolysisJ J Enyeart
Department of Pharmacology, Ohio State University, College of Medicine, Columbus 43210 1239, USA
J Gen Physiol 108:251-64. 1996..The simultaneous activation of A-kinase- and Ca(2+)-dependent pathways produces the full steroidogenic response...
- Role of redox signaling and poly (adenosine diphosphate-ribose) polymerase activation in vascular smooth muscle cell growth inhibition by nitric oxide and peroxynitriteJames Huang
Department of Surgery, San Francisco Veteran s Affairs Medical Center, Division of Vascular Surgery, University of California, San Francisco, USA
J Vasc Surg 47:599-607. 2008..We sought to define the intracellular effects and signaling mechanisms of nitric oxide and peroxynitrite in smooth muscle cells...
- Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitorD Riendeau
Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
Br J Pharmacol 121:105-17. 1997....
- Direct demonstration of a humorally-mediated inhibition of renal phosphate transport in the Hyp mouseD Lajeunesse
Hopital Maisonneuve Rosemont, Montreal, Quebec, Canada
Kidney Int 50:1531-8. 1996..The molecular nature of this factor and its mode of action remains to be determined...
- A new formulation of selegiline: improved bioavailability and selectivity for MAO-B inhibitionA Clarke
Scherer DDS, Swindon, United Kingdom
J Neural Transm (Vienna) 110:1241-55. 2003..25 mg, which is associated with lower concentrations of potentially harmful metabolites, could offer a safer and more predictable treatment in the management of patients with Parkinson's disease...
- Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibitionJennette A Sakoff
Department of Medical Oncology, Newcastle Mater Misericordiae Hospital, Edith Street, 2298 Waratah, NSW, Australia
Cancer Chemother Pharmacol 53:225-32. 2004..In this study the effect of combining PP inhibition with TS inhibition in two colorectal cell lines was examined...
- Glibenclamide-induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized ratC C Wu
William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
Br J Pharmacol 114:1273-81. 1995..9. Thus, glibenclamide inhibits the induction, but not the activity, of iNOS in vitro and in vivo. This inhibition of iNOS induction may contribute to the beneficial haemodynamic effects of glibenclamide in endotoxic shock...
- Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugsShufeng Zhou
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
Clin Pharmacokinet 44:279-304. 2005..The clinical significance of CYP3A inhibition for drug safety and efficacy warrants closer understanding of the mechanisms for each inhibitor. Furthermore, such inactivation may be exploited for therapeutic gain in certain circumstances...
- Examination of the role of inhibition of cyclic AMP in alpha 2-adrenoceptor mediated contractions of the porcine isolated palmar lateral veinI K Wright
Department of Physiology and Pharmacology, Medical School, Queen s Medical Centre, Nottingham
Br J Pharmacol 114:157-65. 1995....
- [Mechanism of hepatocyte regeneration inhibition in rats with liver fibrosis induced by lipogenic methionine-choline- deficient diet]Yong ping Mu
Shanghai Clinical Center for Public Health, Fudan University, Shanghai 201508, China
Zhonghua Yi Xue Za Zhi 89:3430-6. 2009..To obtain the evidence of fibrotic resolution in fatty liver by changing the diet and to clarify the mechanism of hepatocyte proliferation inhibition in rat with fatty liver fibrosis...
- Pharmacological characterization of muscarinic receptor-activated cation channels in guinea-pig ileumS Chen
Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Br J Pharmacol 109:793-801. 1993..The mechanism of inhibition and the relevance to use of these drugs as blockers for the I cat channel are discussed...
- Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophilsE Talpain
Department of Pharmacology, University of Edinburgh
Br J Pharmacol 114:1459-65. 1995..1 AM in its presence.9. These results suggest that inhibition of superoxide generation by PGE2 is mediated by stimulation ofEP2 receptors and activation of adenylate cyclase, leading to the elevation of intracellular levels of cyclic AMP...
- Treatment of the T98G glioblastoma cell line with antisense oligonucleotides directed toward mRNA encoding transforming growth factor-alpha and the epidermal growth factor receptorM Rubenstein
Division of Cellular Biology, Hektoen Institute for Medical Research, Chicago, IL 60612, USA
Med Oncol 18:121-30. 2001..In summary, even at relatively low oligo concentrations and short exposure, oligos against TGF-alpha, and particularly EGFR, significantly inhibit in vitro growth of the T98G glioblastoma, possibly mediated by decreased EGFR expression...
- Decreased venous thrombosis with an oral inhibitor of P selectinDaniel D Myers
Section of Vascular Surgery, Jobst Vascular Research Laboratories, Ann Arbor, Mich, USA
J Vasc Surg 42:329-36. 2005..This study evaluated the effects on thrombosis and circulating microparticle populations in this murine venous thrombosis model...
- Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxonG Amitai
Division of Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
Biochem Pharmacol 56:293-9. 1998..5 x 10(9) vs 1.0 x 10(7) M(-1) min(-1)). The increased rate obtained with the double mutant displaying characteristics of the BChE active center provides a rationale for higher efficacy of CPO scavenging by BChE, compared with AChE...
- Evidence for acyloxymethyl esters of pyrimidine 5'-deoxyribonucleotides as extracellular sources of active 5'-deoxyribonucleotides in cultured cellsJ J Freed
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111
Biochem Pharmacol 38:3193-8. 1989..In the above systems the nucleotide diesters I, II and V appear to be acting as effective extracellular sources of active intracellular FdUMP and TMP, in processes that involve loss of the two esterifying groups...
- Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congenersH D Showalter
Parke Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, Michigan 48106 1047, USA
J Med Chem 40:413-26. 1997..8-day growth delay without appreciable treatment related weight loss. The in vitro and in vivo findings offer a mechanistic rationale as to why the 2,2'-diselenobis(1H-indoles) are more potent inhibitors than their disulfur congeners...
- Constitutive activity of human prostaglandin E receptor EP3 isoformsJ Jin
Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
Br J Pharmacol 121:317-23. 1997....
- Phospholipase-mediated inhibition of spontaneous oscillatory uterine contractions by lindane in vitroChwen Ting Wang
Toxicology Program, Department of Environmental Health Sciences, University of Michigan, Ann Arbor 48109 2029, USA
Toxicol Appl Pharmacol 182:136-47. 2002..These data suggest that lindane inhibits myometrial gap junctions and spontaneous oscillatory contractions by a phospholipase C-mediated pathway...
- Inhibition mechanism of a newly cloned candidate tumor suppressor gene JST during hepatocarcinogenesis and its abnormal expression in human hepatocellular carcinoma from Qidong liver cancer risk area, ChinaLu Dong-Dong
The College of Life Science, Nanjing Normal University, Nanjing, China
Hepatogastroenterology 51:515-25. 2004..To study inhibition effect of a newly cloned candidate tumor suppressor gene (JST) during hepatocarcinogenesis and its normal expression in human hepatocellular carcinoma from Qidong liver cancer risk area, China...
- Mechanism of porcine pancreatic alpha-amylase. Inhibition of amylose and maltopentaose hydrolysis by alpha-, beta- and gamma-cyclodextrinsR Koukiekolo
Institut Méditerranéen de Recherche en Nutrition, Universite d Aix Marseille, France
Eur J Biochem 268:841-8. 2001..Payan, F., Forest, E. & Santimone, M. (1996) Eur. J. Biochem. 241, 787-796]. It is concluded that the hydrolysis of both long and short chain substrates requires at least one secondary binding site, including a tryptophan residue...
- Gi/Go couple met-enkephalin to inhibition of cholinergic and beta-adrenergic stimulation of lacrimal secretionM A Meneray
Department of Physiology, Louisiana State University Medical Center, New Orleans 70119, USA
Cornea 19:92-8. 2000..To determine whether G-protein-mediated inhibition of secretion by met-enkephalin involves cyclic adenosine monophosphate (cAMP)-dependent events and to identify the G proteins that couple met-enkephalin to inhibition of lacrimal secretion...
- Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylationSamarjit Das
Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA
Circ Res 103:983-91. 2008..Both proteomics and adenine nucleotide transport data suggest that GSK regulates VDAC and that VDAC may be an important regulatory site in ischemia/reperfusion injury...
- Mechanisms of mitotic inhibition in corneal endothelium: contact inhibition and TGF-beta2Nancy C Joyce
Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
Invest Ophthalmol Vis Sci 43:2152-9. 2002..Studies were then extended to cultured cells to more directly compare the effects of TGF-beta2 and cell-cell contact on the relative protein and mRNA expression of the CKIs, p27kip1, and p15INK4b...
- Effects of SH-modifying reagents on the rat hepatic Ah receptor: inhibition of ligand binding and transformation, and disruption of the ligand-receptor complexE C Henry
Department of Biophysics, University of Rochester Medical Center, NY 14642
Biochim Biophys Acta 964:361-76. 1988..Our results are in striking contrast to the effects of these reagents on steroid receptors, whose bound steroid hormone ligand is rapidly and reversibly displaced by lower concentrations of reagent.(ABSTRACT TRUNCATED AT 400 WORDS)..
- Acute effects of ethanol on social behavior of adolescent and adult rats: role of familiarity of the test situationElena I Varlinskaya
Developmental Psychobiology, Department of Psychology, Binhamton University, Binghamton, New York 13902 6000, USA
Alcohol Clin Exp Res 26:1502-11. 2002..These issues may be addressed using sensitive animal tests of social behavior...
- CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical modelsBruce Ruggeri
Department of Oncology, Cephalon, Inc, West Chester, Pennsylvania 19380, USA
Cancer Res 63:5978-91. 2003..Orally administered CEP-7055 has entered Phase I clinical trials in cancer patients...
- The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activityB Zingarelli
Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Br J Pharmacol 120:357-66. 1997..The additional effect of mercaptoalkylguanidines on COX activity may contribute to the beneficial effects of these agents in inflammatory conditions where both iNOS and COX-2 are expressed...
- Effects of renin-angiotensin system inhibition on end-organ protection: can we do better?Matthew R Weir
Division of Nephrology, Department of Medicine, University of Maryland School of Medidne, Baltimore, Maryland 21201 1595, USA
Clin Ther 29:1803-24. 2007..Angiotensin receptor blockers (ARBs) selectively antagonize angiotensin II at AT 1 receptors and may also increase activation of the AT 2 receptor and modulate the effects of angiotensin II breakdown products...
- Antinociceptive properties of the hydroalcoholic extract, fractions and compounds obtained from the aerial parts of Baccharis illinita DC in miceCristina Setim Freitas
Department of Pharmacology, Sector of Biological Sciences, Federal University of Parana, Curitiba, PR, Brazil
Basic Clin Pharmacol Toxicol 104:285-92. 2009..Moreover, the antinociceptive action demonstrated in the present study supports the ethnomedical uses of this plant...
- In vivo inhibition of Helicoverpa armigera gut pro-proteinase activation by non-host plant protease inhibitorsVinod D Parde
International Crops Research Institute for the Semi Arid Tropics, Patancheru, India
J Insect Physiol 56:1315-24. 2010..The PIs from the non-host plants can be expressed in genetically engineered plants to confer resistance to H. armigera...
- Mechanisms of alpha,beta-methylene atp-induced inhibition in rat ileal smooth muscle: involvement of intracellular Ca2+ stores in purinergic inhibitionM Storr
Department of Internal Medicine, Technical University of Munich, Germany
Clin Exp Pharmacol Physiol 27:771-9. 2000....
- Differences in the cellular mechanism underlying the effects of amphetamine on prepulse inhibition in apomorphine-susceptible and apomorphine-unsusceptible ratsMartine C J van der Elst
Molecular Neurobiology Section, Department of Cognitive Neurosciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Psychopharmacology (Berl) 190:93-102. 2007..Amphetamine is often used to mimic certain aspects of schizophrenia in laboratory animals, such as a decreased prepulse inhibition...
- Radioligand and functional estimates of the interaction of the 1,4-dihydropyridines, isradipine and lacidipine, with calcium channels in smooth muscleS Salomone
Laboratoire de Pharmacologie, , Bruxelles, Belgium
Br J Pharmacol 109:100-6. 1993....
- The N-terminal acidic domain of heparin cofactor II mediates the inhibition of alpha-thrombin in the presence of glycosaminoglycansV M Van Deerlin
Division of Hematology Oncology, Washington University Medical School, St Louis, Missouri 63110
J Biol Chem 266:20223-31. 1991..These results support a model in which the stimulatory effect of glycosaminoglycans on the inhibition of alpha-thrombin is mediated, in part, by the N-terminal acidic domain of HCII...
- Mechanism of inhibition of human neutrophil collagenase by Gold(I) chrysotherapeutic compounds. Interaction at a heavy metal binding siteS K Mallya
Department of Chemistry, Florida State University, Tallahassee 32306
J Biol Chem 264:1594-601. 1989..Occupancy of this site by Zn(II) is characterized by retention of activity...
- Dopamine D1 receptors and adenosine A1 receptors in the rat nucleus accumbens regulate motor activity but not prepulse inhibitionIsabel Schwienbacher
Tierphysiologie, Universitat Tubingen, Auf der Morgenstelle 28, Germany
Eur J Pharmacol 444:161-9. 2002....
- Assessment of the main metabolism pathways for the flukicidal compound triclabendazole in sheepG Virkel
Laboratorio de Farmacologia, Departmento de Fisiopatologia, Nuncleo Fisfarvet, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina
J Vet Pharmacol Ther 29:213-23. 2006..Comprehension of TCBZ metabolism is critical to optimize its flukicidal activity...
- Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cellsJelmer J van Zanden
Division of Toxicology, Wageningen University, PO Box 8000, 6700 EA, Wageningen, The Netherlands
Biochem Pharmacol 67:1607-17. 2004....
- Characterization of inhibition by haloperidol and chlorpromazine of a voltage-activated K+ current in rat phaeochromocytoma cellsK Nakazawa
Division of Pharmacology, National Institute Health Sciences, Tokyo, Japan
Br J Pharmacol 116:2603-10. 1995..The inhibition may not be related to their activity as antagonists of dopamine D2 receptors or calmodulin antagonists...
- Discovery metabolite profiling of the prolyl peptidasesAlan Saghatelian; Fiscal Year: 2009..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
- Xenoestrogen regulation of Leydig cellsBENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010..Research training to be afforded by the present application to professional veterinary students will contribute to efforts geared to preparing future veterinarians to meet these challenges. ..
- Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductaseSTEPHEN WILLIAM TUTTLE; Fiscal Year: 2010..However, curcumin has been effective in tumors, such as colon and HNC, where direct access to the drug is possible. The primary aim of this study is to develop curcumin as a chemotherapeutic and radiation sensitizer for treating HNC.. ..
- Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of PeriodontitisJUSTIN RODNEY SAVAGE; Fiscal Year: 2011..We propose to develop anionic, partially lipophilic hyaluronic acid derivatives as a simple mechanistically-based treatment for this chronic extraordinarily common dental disorder. ..
- Vaccine Development for Falciparum Malaria in Pregnant Women and Their OffspringIan C Michelow; Fiscal Year: 2013..Candidate vaccine proteins will be screened, confirmed and selected for clinical trials using pioneering molecular tools and blood samples from pregnant African women and their infants. ..
- Brain Activation responses in adolescents with genetic predisposition to obesitySusan Carnell; Fiscal Year: 2011..The results may lead to new drugs and interventions to improve eating behavior, and help establish unbiased indicators of obesity risk and prognosis for use in research and clinical settings. ..
- Exercise training and blood pressure in hypertension: integrated mechanismsNoreen F Rossi; Fiscal Year: 2012....
- Multi-targeted Countermeasures against Acute and Delayed Effects of OP ExposureJohn A Butera; Fiscal Year: 2013..This would set the stage for a final lead optimization campaign focused on identifying pre- clinical leads with well-balanced in vivo PK parameters during an SBIR Phase 2 continuing grant. ..
- Angiotensin Adrenergic Interactions in the KidneyRoland C Blantz; Fiscal Year: 2013....
- Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel MutantsJOHN SAMUEL STAHL; Fiscal Year: 2013....
- Prevention of Acute Lung Injury by IL-6 activated STAT3Ana Moran; Fiscal Year: 2010....
- A Hybrid PARP Inhibitor and Redox Catalyst for Lung TransplantationGARRY JOHN SOUTHAN; Fiscal Year: 2012..At present there are no approved prophylactic measures. We are developing a novel drug that targets the basic mechanisms of this condition and will test this agent in a clinically-relevant animal model. ..
- Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate CancerBandana Chatterjee; Fiscal Year: 2013..Information gleaned from our research may open up new strategies for prevention and clinical management of prostate cancer. ..
- Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular TissueJAMES RUSSELL SOWERS; Fiscal Year: 2013..A better understanding of factors involved in insulin resistance should enable development of therapeutic targets to help prevent diabetes and cardiovascular disease. ..
- Targeting Galectin-3 with novel drugs for treatment of eczemaFu Tong Liu; Fiscal Year: 2010..We hope the proposed studies will definitively validate galectin-3 as a target for treating atopic dermatitis and lead to the development of a novel therapy for this disease. ..
- Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injuryMaria Lauda Tomasi; Fiscal Year: 2012..Three aims are proposed in this application to test these hypotheses and elucidate how SAMe affects signaling pathways that are important in hepatocarcinogenesis and development of alcoholic liver injury. ..
- Effects of Testosterone and Genetic Factors on Psychological and Motor Function iNICOLE RENEE TARTAGLIA; Fiscal Year: 2013....
- Soluble Epoxide Hydrolase as a Target for Ischemic CardioprotectionDonna M Van Winkle; Fiscal Year: 2012..Thus the currently proposed studies are significant in terms of clinical implications for limiting cardiac damage in the vulnerable veteran population and for fiscal health of the Department of Veterans Affairs. ..
- Structure and function of urea transportersMing Zhou; Fiscal Year: 2013..Compounds that selectively block urea transporter will have diuretic effect but will not interfere with the salt balance. ..
- Cystathionine beta synthase (CBS) and angiogenesisPriyabrata Mukherjee; Fiscal Year: 2013....
- Development of VN/14-1 and Related Analogs for Breast Cancer TherapyVINCENT COLLINS OFUKA NJAR; Fiscal Year: 2013..The studies would also lead to the identification of biomarkers that would be useful in clinical trials. ..
- Regulation of B Cell Function by Membrane-Cytoskeletal RemodelingNeetu Gupta; Fiscal Year: 2012..Lessons learnt from understanding the role of ezrin in B cell function can be applied towards therapeutic design for B cell-dependent human diseases. ..
- A Redox-active PARP Inhibitor for Lung TransplantationANDREW LURIE SALZMAN; Fiscal Year: 2012..At present there are no approved prophylactic measures. We are developing a novel drug that targets the basic mechanisms of this condition and will test this agent in two clinically-relevant animal models. ..
- ROLE OF Rac AND REACTIVE OXYGEN SPECIES IN KAPOSI'S SARCOMA VIRAL ONCOGENESISEnrique A Mesri; Fiscal Year: 2013..So our work will allow us to not only to identify mechanisms of KS carcinogenesis but also will help to identify potential new target and new drugs for anti-KS therapy. ..
- Neurobehavioral Correlates of Familial/genetic obesity risk in adolescentsSusan Carnell; Fiscal Year: 2013..abstract_text> ..
- Inhibition of human neutrophil function by Francisella tularensisLee Ann H Allen; Fiscal Year: 2012..The results of this study may lead to new treatments to combat this severe and often fatal lung infection. ..
- Regulation of ER stress-induced cell deathRandal J Kaufman; Fiscal Year: 2013..The proposed studies on protein synthesis will provide vital information that should encourage the development of novel therapeutics to treat diabetes. ..
- Lung Lysyl Oxidase Regulation by Metal Ion HomeostasisWande Li; Fiscal Year: 2013..The outcomes of the proposed research are expected to enhance our understanding of mechanisms of LO gene silence by Cd providing the basis for developing prophylaxis and treatment strategies for Cd-related lung diseases. ..
- The Habenulo-Interpeduncular Pathway and NicotineChristie D Fowler; Fiscal Year: 2013..abstract_text> ..
- A Soft Topical Antiandrogenic DrugWei Chu Xu; Fiscal Year: 2013..The synthesis and discovery of an optimal locally active androgen antagonist to be applied to the skin to treat acne, alopecia, seborrhea (and hirsutism in women) are the subjects of this application. ..
- Translational Machinery in Stress Signaling and Tumor SuppressionTHOMAS J contact BEGLEY; Fiscal Year: 2010..The long term potential of the proposed research is significant, as understanding the mechanisms by which TRM9 inhibits tumor growth may provide novel therapeutic opportunities to restore growth-restricting programs in cancer cells. ..
- Targeting Inflammation for the Amelioration of Cisplatin-Hearing LossVickram Ramkumar; Fiscal Year: 2011..We believe the information gained from this study will lead to potentially new treatments for treating hearing loss. ..
- Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 ReceptorsMark W Chapleau; Fiscal Year: 2013..Inhibition of Ang II-mediated effects by activation of CGRP/RAMP1 receptors has widespread implications in hypertension and heart failure. ..
- Role of IKK in NSCLC: Modulation of SMRT and NF-kappaBMarty W Mayo; Fiscal Year: 2012..The overall goal of this project is use these newly identified gene products as novel therapeutic targets for detection and treatment of NSCLC. ..
- A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced NephropathyKanneganti Murthy; Fiscal Year: 2012..We now propose to test this agent in a clinically-relevant small animal model of radiocontrast-induced kidney failure. ..
- Genistein, microRNAs and kidney cancerRajvir Dahiya; Fiscal Year: 2013..Since the goal of this proposal is to investigate the dietary mediated inhibition of RCC through activation of tumor suppressor miRNAs, we believe that the work proposed is highly relevant to Veterans health and the VA mission. ..
- Prostate cancer chemoprevention by penta-galloyl-glucoseJunxuan Lu; Fiscal Year: 2013..These multiple targeting activities plus published work supporting anti- angiogenesis activity provide strong rationale for testing the efficacy of PGG for prostate cancer chemoprevention. ..
- Hydrodynamic forces modulate renal tubular functionRajeev Rohatgi; Fiscal Year: 2012....
- Epigenetics of Sex Differences in Brain and BehaviorBRIDGET NUGENT; Fiscal Year: 2012....
- Mechanism of Bladder Overactivity in Pelvic IschemiaKazem M Azadzoi; Fiscal Year: 2013..abstract_text> ..
- Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated DementiaXavier Grana; Fiscal Year: 2010....
- Inhibition of IkK to treat lethal Graft-vs.-Host DiseasePatrick Flood; Fiscal Year: 2009..Experiments are proposed in animal models to test the activity of the compound and if successful the long-term goal of this work is to take this compound in human clinical trials for the treatment of GVHD. ..
- TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion InjuryLORI ANN HOLLE; Fiscal Year: 2011....
- Oklahoma Autoimmunity Center of ExcellenceJudith A James; Fiscal Year: 2013..With our rich Native American heritage and large rural populations, the patients provided by the Oklahoma ACE will be previously understudied and provide unique insights for therapeutic trials. ..
- Neural mechanisms by which chronic stress regulates inflammation in asthmaMelissa A Rosenkranz; Fiscal Year: 2013..abstract_text> ..
- Combination drug treatment to inhibit multiple cell death pathways after TBIALAN IRA FADEN; Fiscal Year: 2010....
- The role of IKK beta in cardiomyocytes at baseline and following stressMATTHEW PETER COGGINS; Fiscal Year: 2013..abstract_text> ..
- Prolonged Inhibition of Pathologic Neovascularization by Catalytic AntioxidantsJAMES FRANCIS MCGINNIS; Fiscal Year: 2013....
- The Kallikrein/Kinin-Mast Cell Interaction in Volume OverloadCHIH CHANG KEVIN WEI; Fiscal Year: 2013....
- Targeting iNOS to inhibit myeloid-derived suppressor cells (MDSC) in melanomaANDREW GREGORY SIKORA; Fiscal Year: 2013..abstract_text> ..
- New insights in mechanisms of renal injuryBalakuntalam S Kasinath; Fiscal Year: 2013..Upstream regulators and downstream effectors of GSK 3beta in transcription and translation pathways involved in matrix protein synthesis will be explored in renal tissues as stated in Aim 1. ..
- BONE MATRIX AND BONE RESORPTIONPaul R Odgren; Fiscal Year: 2012..This proposal aims to investigate new genes that regulate the formation and activity of osteoclasts to better understand bone biology in general, and potentially to find new ways to treat these widespread bone disorders. ..
- Bisphosphonates in the treatment of chronic kidney disease-mineral bone diseaseSharon M Moe; Fiscal Year: 2013..Both of these problems may be linked. The purpose of this study is to determine if a commonly used group of drugs, bisphosphonates, may help both bone and heart/blood vessel disease and determine the mechanism the drugs work. ..
- Notch and Regulators of Notch Signaling Impact Both Glucose and Lipid MetabolismUTPAL BHAGIRATH PAJVANI; Fiscal Year: 2013..Pajvani will need in order to become an independent translational medical researcher and a productive member of the academic medical community. ..
- A Thioredoxin Mimetic for Radiocontrast NephropathyGARRY JOHN SOUTHAN; Fiscal Year: 2012..We now propose to test this agent in a clinically-relevant small animal model of radiocontrast-induced kidney failure. ..
- Adenosine and the Basal Forebrain in the Control of Behavioral StateRobert E Strecker; Fiscal Year: 2012..In conclusion, there is a direct path from our studies on animal models to related clinical research, which could lead to improved medical care of veterans. ..
- TARGETING THE MARCKS-FAMILY PROTEINS TO INHIBIT NEUTROPHIL MIGRATIONMary K Sheats; Fiscal Year: 2013....
- Purkinje Origin of Ischemic Ventricular Tachycardia and FibrillationJames B Martins; Fiscal Year: 2013..Similarly such drugs may be combined with other antioxidants to prevent dangerous heart rhythms. ..
- Identification and Analysis of Flavivirus Protease and RNA Helicase InhibitorsRadhakrishnan Padmanabhan; Fiscal Year: 2009....
- Mechanisms of Endothelin 1-Induced Sickle Cell PathologyAlicia Rivera; Fiscal Year: 2011..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
- A quantitative proteomics approach to understand viral immune evasion strategiesMichele E Hardy; Fiscal Year: 2010..Understanding these pathways and the mechanisms by which viruses evade the innate immune response may lead new approaches to attenuated vaccines or antiviral drug targets specifically designed to bypass viral evasion strategies. ..
- Gene Therapy with Cardiotropic Vectors for the Treatment of Heart FailureRoger J Hajjar; Fiscal Year: 2013....
- Structural Basis for Chemokine FunctionBrian F Volkman; Fiscal Year: 2013..New inhibitors and variants of SDF developed in this project will likely find application as diagnostic and therapeutic agents in a wide range of human diseases, including cardiovascular disease, cancer and multiple sclerosis. ..
- Mechanism of Translation Elongation Factor 2 Inhibition by Bacterial ToxinsTerri Goss Kinzy; Fiscal Year: 2010....
- Development of Novel Small Molecule Flavivirus InhibitorsERIC W BARKLIS; Fiscal Year: 2010..Our results will lead to the development of new antivirals, and an understanding of how they work. ..
- DiosMemTM, a natural gamma-secretase inhibitor, opposes AD pathogenesisJun Tan; Fiscal Year: 2009..These studies will lay the foundation for AD clinical trials with DiosMemTM in the near future. ..
- CARDIOPROTECTIVE AGENTS IN ISCHEMIC MYOCYTESRICHARD HONKANEN; Fiscal Year: 2002..Further study of the effects of this PP inhibitor may lead to greater insight concerning downstream effectors of preconditioning. ..
- Inhibition of glutathione reductase and ovarian cancer drug resistance reversalXiangming Guan; Fiscal Year: 2006..The long term objective of this project is to extend these approaches to other GSH-mediated drug resistant cancers. [unreadable] [unreadable] [unreadable] [unreadable]..
- CELLULAR EFFECTS OF INHIBITION OF THYMIDYLATE SYNTHASERICHARD MORAN; Fiscal Year: 1993..Finally, an explanation for the limited increase in the host toxicity of 5-FU when folinic acid is simultaneously administered will be sought on a biochemical level...
- Role of G-gamma-7 in striatal cannabinoid and D2 dopamineDana E Selley; Fiscal Year: 2010..These studies will provide information that contributes to our understanding of the neural mechanisms of drug addiction and possibly neuropsychiatric and movement disorders, such as schizophrenia and Parkinsonism. ..
- Targeting the leukemia microenvironment by CXCR4 inhibition in stem cell transplaMarina Y Konopleva; Fiscal Year: 2010..This will be done in a setting of allogeneic hematopoietic stem cell transplantation in which hematologic recovery is derived from donor cells. ..
- Structural Mechanisms for the Inhibition of ThrombosisJAMES HUNTINGTON; Fiscal Year: 2009....
- Development of Transdermal Films for the the Delivery of HIV TherapeuticsAnthony Sang Won Ham; Fiscal Year: 2010..The research to be performed will include development of the transdermal film and the evaluation of its ability to deliver a therapeutic amount of IQP-0410 over long periods of time. ..
- NEUROBIOLOGY OF PUBERTYHELEN I ANSON; Fiscal Year: 1993....
- DNA Methyltransferase Inhibition by Intercalating AgentsKeith D Robertson; Fiscal Year: 2010..Elucidating the molecular mechanism of a widely utilized class of anticancer drugs known as DNA intercalators is the focus of this proposal. ..
- Glutathione reductase and tumor sensitivity to radiationXiangming Guan; Fiscal Year: 2003..The long-term objective is to develop a novel approach to increase cancer sensitivity to radiation. ..
- Mechanisms of Hemostatic Protease Inhibition by SerpinsIngrid M Verhamme; Fiscal Year: 2010..They may facilitate development of novel anticoagulants based on HCII and DS specifically targeted to arterial thrombosis. ..
- MOLECULAR MECHANISMS OF ASPIRIN IN CANCER PREVENTIONZigang Dong; Fiscal Year: 2001..Furthermore, we will test whether the same dosage of aspirin that inhibits tumor promoter-induced AP-1 activity also inhibits tumor promotion in the transgenic mice. ..
- Gene silencing of phosphodiesterase-4D (PDE4D) as a therapeutic approach to beta Han Ting Zhang; Fiscal Year: 2009....