Summary: Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.

Top Publications

  1. pmc From inflammation to sickness and depression: when the immune system subjugates the brain
    Robert Dantzer
    Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
    Nat Rev Neurosci 9:46-56. 2008
  2. pmc Antidepressant drug effects and depression severity: a patient-level meta-analysis
    Jay C Fournier
    Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    JAMA 303:47-53. 2010
  3. ncbi An inventory for measuring depression
    A T Beck
    Arch Gen Psychiatry 4:561-71. 1961
  4. pmc The PHQ-9: validity of a brief depression severity measure
    K Kroenke
    Regenstrief Institute for Health Care and Department of Medicine, Indiana University, Indianapolis 46202, USA
    J Gen Intern Med 16:606-13. 2001
  5. doi Internet-based psychological treatments for depression
    Robert Johansson
    Department of Behavioural Sciences and Learning, Linkoping University, SE 58183 Linkoping, Sweden
    Expert Rev Neurother 12:861-9; quiz 870. 2012
  6. pmc Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
    Jason S Snyder
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 476:458-61. 2011
  7. ncbi Neurobiology of depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Neuron 34:13-25. 2002
  8. ncbi Collaborative care for depression: a cumulative meta-analysis and review of longer-term outcomes
    Simon Gilbody
    Department of Health Sciences, University of York, York, England
    Arch Intern Med 166:2314-21. 2006
  9. ncbi The prevalence of comorbid depression in adults with diabetes: a meta-analysis
    R J Anderson
    Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
    Diabetes Care 24:1069-78. 2001
  10. pmc Depression and type 2 diabetes over the lifespan: a meta-analysis
    Briana Mezuk
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes Care 31:2383-90. 2008

Detail Information

Publications316 found, 100 shown here

  1. pmc From inflammation to sickness and depression: when the immune system subjugates the brain
    Robert Dantzer
    Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
    Nat Rev Neurosci 9:46-56. 2008
    ..immune signalling to the brain can lead to an exacerbation of sickness and the development of symptoms of depression in vulnerable individuals...
  2. pmc Antidepressant drug effects and depression severity: a patient-level meta-analysis
    Jay C Fournier
    Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    JAMA 303:47-53. 2010
    ..medications represent the best established treatment for major depressive disorder, but there is little evidence that they have a specific pharmacological effect relative to pill placebo for patients with less severe depression.
  3. ncbi An inventory for measuring depression
    A T Beck
    Arch Gen Psychiatry 4:561-71. 1961
  4. pmc The PHQ-9: validity of a brief depression severity measure
    K Kroenke
    Regenstrief Institute for Health Care and Department of Medicine, Indiana University, Indianapolis 46202, USA
    J Gen Intern Med 16:606-13. 2001
    While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity.
  5. doi Internet-based psychological treatments for depression
    Robert Johansson
    Department of Behavioural Sciences and Learning, Linkoping University, SE 58183 Linkoping, Sweden
    Expert Rev Neurother 12:861-9; quiz 870. 2012
    Major depression is highly prevalent, and is associated with high societal costs and individual suffering. Evidence-based psychological treatments obtain good results, but access to these treatments is limited...
  6. pmc Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
    Jason S Snyder
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 476:458-61. 2011
    ..Decreased neurogenesis has been implicated in the pathogenesis of anxiety and depression, but direct evidence for this role is lacking...
  7. ncbi Neurobiology of depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Neuron 34:13-25. 2002
    Current treatments for depression are inadequate for many individuals, and progress in understanding the neurobiology of depression is slow...
  8. ncbi Collaborative care for depression: a cumulative meta-analysis and review of longer-term outcomes
    Simon Gilbody
    Department of Health Sciences, University of York, York, England
    Arch Intern Med 166:2314-21. 2006
    b>Depression is common in primary care but is suboptimally managed...
  9. ncbi The prevalence of comorbid depression in adults with diabetes: a meta-analysis
    R J Anderson
    Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
    Diabetes Care 24:1069-78. 2001
    OBJECTIVE--To estimate the odds and prevalence of clinically relevant depression in adults with type 1 or type 2 diabetes...
  10. pmc Depression and type 2 diabetes over the lifespan: a meta-analysis
    Briana Mezuk
    Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes Care 31:2383-90. 2008
    It has been argued that the relationship between depression and diabetes is bi-directional, but this hypothesis has not been explicitly tested...
  11. doi Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis
    M Bryant Howren
    Department of Psychology, The University of Iowa, 11 Seashore Hall East, Iowa City, IA 52242, USA
    Psychosom Med 71:171-86. 2009
    To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples.
  12. ncbi Stress, depression, and neuroplasticity: a convergence of mechanisms
    Christopher Pittenger
    Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 6508, USA
    Neuropsychopharmacology 33:88-109. 2008
    ..Here we provide an overview of the evidence that chronic stress, which can precipitate or exacerbate depression, disrupts neuroplasticity, while antidepressant treatment produces opposing effects and can enhance ..
  13. doi Is guided self-help as effective as face-to-face psychotherapy for depression and anxiety disorders? A systematic review and meta-analysis of comparative outcome studies
    P Cuijpers
    Department of Clinical Psychology, VU University Amsterdam, The Netherlands
    Psychol Med 40:1943-57. 2010
    Although guided self-help for depression and anxiety disorders has been examined in many studies, it is not clear whether it is equally effective as face-to-face treatments...
  14. pmc Motivators and motivations to persist with online psychological interventions: a qualitative study of treatment completers
    Liesje Donkin
    Brain and Mind Institute, The University of Sydney, Camperdown, Australia
    J Med Internet Res 14:e91. 2012
    ..However, while studies have begun to explore the predictors of dropout in Internet interventions, few have explored reasons why users persist with the programs, which may not just be the converse of the reasons for dropout...
  15. pmc Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
    Denis J David
    Université Paris Sud EA 3544, Faculte de Pharmacie, Chatenay Malabry Cedex F 92296, France
    Neuron 62:479-93. 2009
    ..Importantly, mice deficient in one of these genes, beta-arrestin 2, displayed a reduced response to fluoxetine in multiple tasks, suggesting that beta-arrestin signaling is necessary for the antidepressant effects of fluoxetine...
  16. pmc Cross-national epidemiology of DSM-IV major depressive episode
    Evelyn Bromet
    Department of Psychiatry, State University of New York at Stony Brook, South Campus, Stony Brook, NY 11794 8790, NY, USA
    BMC Med 9:90. 2011
    Major depression is one of the leading causes of disability worldwide, yet epidemiologic data are not available for many countries, particularly low- to middle-income countries...
  17. ncbi Depression and diabetes: impact of depressive symptoms on adherence, function, and costs
    P S Ciechanowski
    Box 356560, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Arch Intern Med 160:3278-85. 2000
    b>Depression is common among patients with chronic medical illness...
  18. doi The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods
    Brenda W J H Penninx
    Department of Psychiatry EMGO Institute Institute for Neurosciences, VU University Medical Centre, Amsterdam, The Netherlands
    Int J Methods Psychiatr Res 17:121-40. 2008
    The Netherlands Study of Depression and Anxiety (NESDA) is a multi-site naturalistic cohort study to: (1) describe the long-term course and consequences of depressive and anxiety disorders, and (2) to integrate biological and psychosocial ..
  19. pmc Effectiveness of a novel integrative online treatment for depression (Deprexis): randomized controlled trial
    Björn Meyer
    Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistr 52, Building O59, 20246 Hamburg, Germany
    J Med Internet Res 11:e15. 2009
    b>Depression is associated with immense suffering and costs, and many patients receive inadequate care, often because of the limited availability of treatment...
  20. ncbi A new approach on stress-related depression & anxiety: Neuro-Psycho- Physical-Optimization with Radio Electric Asymmetric-Conveyer
    Salvatore Rinaldi
    Rinaldi Fontani Institute, Florence, Italy
    Indian J Med Res 132:189-94. 2010
  21. doi Association of torture and other potentially traumatic events with mental health outcomes among populations exposed to mass conflict and displacement: a systematic review and meta-analysis
    Zachary Steel
    Psychiatry Research and Teaching Unit, School of Psychiatry, University New South Wales, Liverpool New South Wales, Australia
    JAMA 302:537-49. 2009
    ..torture and other potentially traumatic events (PTEs), play in the variation of reported prevalence rates of posttraumatic stress disorder (PTSD) and depression across epidemiologic surveys among postconflict populations worldwide.
  22. ncbi Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness
    H S Mayberg
    Research Imaging Center, University of Texas Health Science Center at San Antonio, USA
    Am J Psychiatry 156:675-82. 1999
    ..Expanding on this theory, this study examined functional interactions between specific limbic and neocortical regions accompanying normal and disease-associated shifts in negative mood state...
  23. ncbi [Measuring the quality of life in economic evaluations: the Dutch EQ-5D tariff]
    L M Lamers
    Instituut Beleid en Management Gezondheidszorg, Erasmus MC, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 149:1574-8. 2005
    ..To value EQ-5D health states by a general Dutch public. EQ-5D is a standardised questionnaire that is used to calculate quality-adjusted life-years for cost-utility analysis...
  24. pmc Effectiveness of a web-based self-help intervention for symptoms of depression, anxiety, and stress: randomized controlled trial
    Annemieke van Straten
    FPP, Department of Clinical Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    J Med Internet Res 10:e7. 2008
    ..We developed a new Web-based self-help intervention based on problem-solving therapy, which may be used for people with different types of comorbid problems: depression, anxiety, and work-related stress.
  25. ncbi The Patient Health Questionnaire-2: validity of a two-item depression screener
    Kurt Kroenke
    Regenstrief Institute for Health Care and Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
    Med Care 41:1284-92. 2003
    A number of self-administered questionnaires are available for assessing depression severity, including the 9-item Patient Health Questionnaire depression module (PHQ-9)...
  26. pmc Cytokines sing the blues: inflammation and the pathogenesis of depression
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
    Trends Immunol 27:24-31. 2006
    Increasing amounts of data suggest that inflammatory responses have an important role in the pathophysiology of depression. Depressed patients have been found to have higher levels of proinflammatory cytokines, acute phase proteins, ..
  27. ncbi Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case-control study
    Annika Rosengren
    Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Lancet 364:953-62. 2004
    ..The aim of the present analysis was to investigate the relation of psychosocial factors to risk of myocardial infarction in 24767 people from 52 countries...
  28. ncbi Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
    Nadia M Tsankova
    The University of Texas Southwestern Medical Center, Department of Psychiatry and Center for Basic Neuroscience, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 9:519-25. 2006
    To better understand the molecular mechanisms of depression and antidepressant action, we administered chronic social defeat stress followed by chronic imipramine (a tricyclic antidepressant) to mice and studied adaptations at the levels ..
  29. pmc Intimate partner violence against adult women and its association with major depressive disorder, depressive symptoms and postpartum depression: a systematic review and meta-analysis
    Hind A Beydoun
    Graduate Program in Public Health, Eastern Virginia Medical School, Post Office Box 1980, Norfolk, VA 23501 1980, USA
    Soc Sci Med 75:959-75. 2012
    ..have been conducted to comprehensively evaluate the co-morbidity of intimate partner violence (IPV) and specific depression outcomes in women...
  30. ncbi Normative data for the HADS from a large non-clinical sample
    J R Crawford
    Department of Psychology, King s College, University of Aberdeen, Aberdeen AB24 2UB, UK
    Br J Clin Psychol 40:429-34. 2001
    To provide normative data for the Hospital Anxiety Depression Scale (HADS).
  31. ncbi Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy
    A Rozanski
    Division of Cardiology, Department of Medicine, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Circulation 99:2192-217. 1999
    ..This evidence is composed largely of data relating CAD risk to 5 specific psychosocial domains: (1) depression, (2) anxiety, (3) personality factors and character traits, (4) social isolation, and (5) chronic life stress...
  32. ncbi Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions
    Vaishnav Krishnan
    Department of Psychiatry, The University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Cell 131:391-404. 2007
  33. ncbi Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Nat Genet 36:1319-25. 2004
    ..hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the causality as well as the treatment of depression. To investigate a possible association between genes regulating the HPA axis and response to antidepressants and ..
  34. ncbi The association of depression and anxiety with medical symptom burden in patients with chronic medical illness
    Wayne Katon
    Department of Psychiatry, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
    Gen Hosp Psychiatry 29:147-55. 2007
    Primary care patients with anxiety and depression often describe multiple physical symptoms, but no systematic review has studied the effect of anxiety and depressive comorbidity in patients with chronic medical illnesses.
  35. pmc IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress
    Ja Wook Koo
    Department of Psychology, Yale University, New Haven, CT 06520 8205, USA
    Proc Natl Acad Sci U S A 105:751-6. 2008
    ..hippocampus, and blockade of this effect is required for the actions of antidepressants in behavioral models of depression. However, the mechanisms underlying these effects of stress have not been identified...
  36. ncbi Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses
    Tim F Oberlander
    Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Epigenetics 3:97-106. 2008
  37. ncbi Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS
    Paul Willner
    Department of Psychology, University of Wales Swansea, Swansea, UK
    Neuropsychobiology 52:90-110. 2005
    The chronic mild stress (CMS) model of depression has high validity but has in the past been criticized for being difficult to replicate...
  38. pmc Real-time self-regulation of emotion networks in patients with depression
    David E J Linden
    Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, United Kingdom
    PLoS ONE 7:e38115. 2012
    Many patients show no or incomplete responses to current pharmacological or psychological therapies for depression. Here we explored the feasibility of a new brain self-regulation technique that integrates psychological and ..
  39. doi Exercise for depression
    Jane Rimer
    University Hospitals Division, NHS Lothian, Edinburgh, Scotland, UK
    Cochrane Database Syst Rev 7:CD004366. 2012
    b>Depression is a common and important cause of morbidity and mortality worldwide. Depression is commonly treated with antidepressants and/or psychotherapy, but some people may prefer alternative approaches such as exercise...
  40. ncbi The Liebowitz Social Anxiety Scale: a comparison of the psychometric properties of self-report and clinician-administered formats
    D M Fresco
    Adult Anxiety Clinic of Temple University, Philadelphia, PA 19122-6085, USA
    Psychol Med 31:1025-35. 2001
    ..CONCLUSION: Results of this study suggest that the self-report version of the LSAS compares well to the clinician-administered version and may be validly employed in the assessment of social anxiety disorder...
  41. pmc Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease
    Mary A Whooley
    VA Medical Center, San Francisco, California, USA
    JAMA 300:2379-88. 2008
    ..Depressive symptoms predict adverse cardiovascular outcomes in patients with coronary heart disease, but the mechanisms responsible for this association are unknown...
  42. pmc Dietary pattern and depressive symptoms in middle age
    Tasnime N Akbaraly
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK
    Br J Psychiatry 195:408-13. 2009
    Studies of diet and depression have focused primarily on individual nutrients.
  43. doi Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies
    Chiara Baglioni
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Hauptstrasse 5, 79104 Freiburg, Germany
    J Affect Disord 135:10-9. 2011
    In many patients with depression, symptoms of insomnia herald the onset of the disorder and may persist into remission or recovery, even after adequate treatment...
  44. ncbi Depression and pain comorbidity: a literature review
    Matthew J Bair
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Arch Intern Med 163:2433-45. 2003
    Because depression and painful symptoms commonly occur together, we conducted a literature review to determine the prevalence of both conditions and the effects of comorbidity on diagnosis, clinical outcomes, and treatment...
  45. pmc Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
    Brain Struct Funct 213:93-118. 2008
    ..Such findings hold major implications for models of the neurocircuits that underlie depression. In particular evidence from lesion analysis studies suggests that the MPFC and related limbic and striato-..
  46. pmc mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
    Nanxin Li
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Science 329:959-64. 2010
    ..of mTOR signaling completely blocked ketamine induction of synaptogenesis and behavioral responses in models of depression. Our results demonstrate that these effects of ketamine are opposite to the synaptic deficits that result from ..
  47. ncbi The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms
    Kurt Kroenke
    Regenstrief Institute for Health Care, Department of Medicine, Indiana University, RG 6 1050 Wishard Blvd, Indianapolis, IN 46202, USA
    Psychosom Med 64:258-66. 2002
    ..However, instruments for identifying and monitoring somatic symptoms are few in number and not widely used. Therefore, we examined the validity of a brief measure of the severity of somatic symptoms...
  48. ncbi A review of psychological risk factors in back and neck pain
    S J Linton
    Department of Occupational and Environmental Medicine, Orebro Medical Center, Orebro, Sweden
    Spine (Phila Pa 1976) 25:1148-56. 2000
    ..The literature on psychological factors in neck and back pain was systematically searched and reviewed...
  49. doi Depression and obesity: a meta-analysis of community-based studies
    Leonore de Wit
    Department of Clinical Psychology and EMGO Institute, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
    Psychiatry Res 178:230-5. 2010
    To examine the nature of the association between depression and obesity and to determine possible underlying (demographic) factors, we conducted a meta-analysis of cross-sectional studies in the general population...
  50. pmc Depression and diabetes treatment nonadherence: a meta-analysis
    Jeffrey S Gonzalez
    Behavioral Medicine, Department of Psychiatry, Massachusetts General Hospital Boston, Boston, Massachusetts, USA
    Diabetes Care 31:2398-403. 2008
    b>Depression is common in patients with diabetes and is associated with worse treatment outcomes. Its relationship to treatment adherence, however, has not been systematically reviewed...
  51. pmc Internet treatment for depression: a randomized controlled trial comparing clinician vs. technician assistance
    Nickolai Titov
    Clinical Research Unit for Anxiety and Depression, School of Psychiatry, University of New South Wales at St Vincent s Hospital, Sydney, New South Wales, Australia
    PLoS ONE 5:e10939. 2010
    Internet-based cognitive behavioural therapy (iCBT) for depression is effective when guided by a clinician, less so if unguided.
  52. pmc The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex
    Michael Koenigs
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Blvd, Madison, WI 53719, USA
    Behav Brain Res 201:239-43. 2009
    A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms...
  53. doi Exercise for depression
    Gary M Cooney
    Division of Psychiatry, Royal Edinburgh Hospital, NHS Lothian, Edinburgh, Midlothian, UK, EH9 1ED
    Cochrane Database Syst Rev 9:CD004366. 2013
    b>Depression is a common and important cause of morbidity and mortality worldwide. Depression is commonly treated with antidepressants and/or psychological therapy, but some people may prefer alternative approaches such as exercise...
  54. pmc So depression is an inflammatory disease, but where does the inflammation come from?
    Michael Berk
    IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Vic, Australia
    BMC Med 11:200. 2013
    We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system...
  55. ncbi Depression: a new animal model sensitive to antidepressant treatments
    R D Porsolt
    Nature 266:730-2. 1977
  56. pmc NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
    Anita E Autry
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9111, USA
    Nature 475:91-5. 2011
    ..Our findings indicate that the regulation of protein synthesis by spontaneous neurotransmission may serve as a viable therapeutic target for the development of fast-acting antidepressants...
  57. pmc Glucocorticoids, cytokines and brain abnormalities in depression
    Patricia A Zunszain
    Stress, Psychiatry and Immunology Laboratory SPI Lab, Department of Psychological Medicine, Institute of Psychiatry, King s College London, 125 Coldharbour Lane, SE59NU London, United Kingdom
    Prog Neuropsychopharmacol Biol Psychiatry 35:722-9. 2011
    Major depression (MD) is a common psychiatric disorder with a complex and multifactor aetiology...
  58. ncbi Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
    Yukihiko Shirayama
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:3251-61. 2002 test the hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms...
  59. ncbi Socioeconomic inequalities in depression: a meta-analysis
    V Lorant
    Health Systems Research, School of Public Health, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    Am J Epidemiol 157:98-112. 2003
    ..Among psychiatric disorders, depression exhibits a more controversial association with SES...
  60. ncbi Exercise builds brain health: key roles of growth factor cascades and inflammation
    Carl W Cotman
    University of California, Irvine Institute for Brain Aging and Dementia, 1113 Gillespie Building, Irvine, CA 92617 4540, USA
    Trends Neurosci 30:464-72. 2007
    ..of exercise have been best defined for learning and memory, protection from neurodegeneration and alleviation of depression, particularly in elderly populations...
  61. pmc Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis
    A Nouwen
    School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Diabetologia 53:2480-6. 2010
    An earlier meta-analysis showed that diabetes is a risk factor for the development and/or recurrence of depression. Yet whether this risk is different for studies using questionnaires than for those relying on diagnostic criteria for ..
  62. ncbi Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence
    David M Clarke
    Psychological Medicine, Monash University, Melbourne, Vic, Australia
    Med J Aust 190:S54-60. 2009
    To review the evidence for an association between depression and anxiety and the National Health Priority Area conditions -- heart disease, stroke, diabetes mellitus, asthma, cancer, arthritis and osteoporosis -- and for the effectiveness ..
  63. pmc Reconsidering anhedonia in depression: lessons from translational neuroscience
    Michael T Treadway
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Neurosci Biobehav Rev 35:537-55. 2011
    ..These proposed modifications to the theoretical definition of anhedonia have implications for research, assessment and treatment of MDD...
  64. ncbi Epidemiology of women and depression
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Suite 215, Boston, MA 02115 5899, USA
    J Affect Disord 74:5-13. 2003
    b>Depression is the leading cause of disease-related disability among women in the world today. Depression is much more common among women than men, with female/male risk ratios roughly 2:1.
  65. pmc Bidirectional association between depression and type 2 diabetes mellitus in women
    An Pan
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 170:1884-91. 2010
    Although it has been hypothesized that the diabetes-depression relation is bidirectional, few studies have addressed this hypothesis in a prospective setting.
  66. ncbi Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment
    Helen S Mayberg
    Department of Psychiatry and the Rotman Research Institute, University of Toronto, Ontario, Canada
    Br Med Bull 65:193-207. 2003
    While characterization of pathogenetic mechanisms underlying major depression is a fundamental aim of neuroscience research, an equally critical clinical goal is to identify biomarkers that might improve diagnostic accuracy and guide ..
  67. doi Cognitive theory and therapy of anxiety and depression: convergence with neurobiological findings
    David A Clark
    Department of Psychology, University of New Brunswick, P O Box 4400, Fredericton, New Brunswick E3B5A3, Canada
    Trends Cogn Sci 14:418-24. 2010
    ..Beck's cognitive formulation of anxiety and depression is proposed that provides an elaborated account of the cognitive and neural mediational processes of cognitive ..
  68. ncbi The ascent of mouse: advances in modelling human depression and anxiety
    John F Cryan
    Neuroscience Research, Novartis Institutes for BioMedical Research, Basel CH 4055, Switzerland
    Nat Rev Drug Discov 4:775-90. 2005
    ..The success of this approach is largely contingent on the usefulness of available behavioural models of depression- and anxiety-related behaviours in mice...
  69. doi A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults
    Jun S Lai
    Priority Research Centre for Gender, Health and Ageing JSL and AJH, the Priority Research Centre for Translational Neuroscience and Mental Health SH, and the Centre for Clinical Epidemiology and Biostatistics MM and JA, University of Newcastle, New South Wales, Australia The Hunter Medical Research Institute, Newcastle, New South Wales, Australia AB, AJH, and JA and the John Hunter Hospital, Newcastle, New South Wales, Australia JA
    Am J Clin Nutr 99:181-97. 2014
    Studies of single nutrients on depression have produced inconsistent results, and they have failed to consider the complex interactions between nutrients...
  70. doi Physical activity, exercise, depression and anxiety disorders
    Andreas Strohle
    Department of Psychiatry and Psychotherapy, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    J Neural Transm (Vienna) 116:777-84. 2009
    ..with respect to (1) the association of physical activity, exercise and the prevalence and incidence of depression and anxiety disorders and (2) the potential therapeutic activity of exercise training in patients with ..
  71. doi New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors
    Michael Maes
    Maes 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Inflammopharmacology 20:127-50. 2012
    This paper reviews new drug targets in the treatment of depression and new drug candidates to treat depression...
  72. pmc Depressed mood in pregnancy: prevalence and correlates in two Cape Town peri-urban settlements
    Mary Hartley
    Department of Psychology, Stellenbosch University, Private Bag X1, Matieland, 7602, South Africa
    Reprod Health 8:9. 2011
    The disability associated with depression and its impact on maternal and child health has important implications for public health policy...
  73. ncbi The NPY system in stress, anxiety and depression
    Markus Heilig
    Division of Psychiatry, Neurotec Department, Karolinska Institute, Huddinge University Hospital M57, Stockholm 141 86, Sweden Laboratory of Clinical Science, NIAAA NIH, Bethesda, MD, USA
    Neuropeptides 38:213-24. 2004
    ..NPY system as a target for novel pharmacological treatments of stress-related disorders, including anxiety and depression. Development of Y2 antagonists presently appears to offer the most promising strategy for developing these ..
  74. doi Burden, depression, and anxiety in caregivers of people with amyotrophic lateral sclerosis
    Francesco Pagnini
    Department of Psychology, Catholic University of Milan, Milan, Italy
    Psychol Health Med 15:685-93. 2010
    ..We conducted a cross-sectional study among 40 ALS caregivers, assessing general worries, burden of care, depression, anxiety, perception of social support, and patients' severity of disease...
  75. ncbi Depression in the elderly
    George S Alexopoulos
    Weill Medical College of Cornell University and Weill Cornell Institute of Geriatric Psychiatry, 21 Bloomingdale Road, White Plains, New York, NY 10605, USA
    Lancet 365:1961-70. 2005
    In elderly people, depression mainly affects those with chronic medical illnesses and cognitive impairment, causes suffering, family disruption, and disability, worsens the outcomes of many medical illnesses, and increases mortality...
  76. ncbi Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research Study
    J R Ickovics
    Yale University, Department of Epidemiology and Public Health, PO Box 208034, 60 College St, Suite 415, New Haven, CT 06520 8034, USA
    JAMA 285:1466-74. 2001
    The impact of depression on morbidity and mortality among women with human immunodeficiency virus (HIV) has not been examined despite the fact that women with HIV have substantially higher rates of depression than their male counterparts.
  77. ncbi Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial
    Lisa F Berkman
    Harvard University, Boston, MA, USA
    JAMA 289:3106-16. 2003
    b>Depression and low perceived social support (LPSS) after myocardial infarction (MI) are associated with higher morbidity and mortality, but little is known about whether this excess risk can be reduced through treatment.
  78. doi Depression and cardiac disease: a review
    Christopher M Celano
    Harvard Medical School, Boston, MA, USA
    Cardiol Rev 19:130-42. 2011
    b>Depression is highly prevalent in cardiac patients, with 20% to 40% of patients meeting criteria for major depressive disorder or experiencing an elevation in depressive symptoms...
  79. ncbi Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
    ..These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences...
  80. ncbi Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence
    M R DiMatteo
    Department of Psychology, University of California, Riverside, CA 92521, USA
    Arch Intern Med 160:2101-7. 2000
    b>Depression and anxiety are common in medical patients and are associated with diminished health status and increased health care utilization...
  81. ncbi Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
    Avshalom Caspi
    Medical Research Council Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, PO80 De Crespigny Park, London, SE5 8AF, UK
    Science 301:386-9. 2003
    In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others...
  82. ncbi Family caregiving of persons with dementia: prevalence, health effects, and support strategies
    Richard Schulz
    University Center for Social and Urban Research, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Am J Geriatr Psychiatry 12:240-9. 2004 effects of caregiving, and reviews various intervention approaches to improving caregiver burden, depression, and quality of life...
  83. pmc The Hospital Anxiety And Depression Scale
    R Philip Snaith
    Senior Lecturer in Psychiatry, University of Leeds, 21 Gledhow Wood Road, Leeds LS8 4BW, UK
    Health Qual Life Outcomes 1:29. 2003
    There is a need to assess the contribution of mood disorder, especially anxiety and depression, in order to understand the experience of suffering in the setting of medical practice...
  84. pmc Systemic inflammation, depression and obstructive pulmonary function: a population-based study
    Yanxia Lu
    Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, and Department of Psychological Medicine, National University Hospital System, NUHS Tower Block, 9th Floor, 1E Kent Ridge Road, 119228 Singapore, Singapore
    Respir Res 14:53. 2013
    ..are known to be elevated in chronic diseases including chronic obstructive pulmonary disease (COPD) and depression. Comorbid depression is common in patients with COPD, but no studies have investigated whether proinflammatory ..
  85. pmc The molecular neurobiology of depression
    Vaishnav Krishnan
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 455:894-902. 2008
    Unravelling the pathophysiology of depression is a unique challenge. Not only are depressive syndromes heterogeneous and their aetiologies diverse, but symptoms such as guilt and suicidality are impossible to reproduce in animal models...
  86. doi Yoga for depression: a systematic review and meta-analysis
    Holger Cramer
    Department of Internal and Integrative Medicine, Kliniken Essen Mitte, Faculty of Medicine, University of Duisburg Essen, Essen, Germany
    Depress Anxiety 30:1068-83. 2013
    Mind-body medical interventions are commonly used to cope with depression and yoga is one of the most commonly used mind-body interventions...
  87. ncbi Patterns of association between alcohol consumption and symptoms of depression and anxiety in young adults
    T M Caldwell
    Centre for Mental Health Research, Australian National University, Canberra, ACT
    Addiction 97:583-94. 2002
    ..Little is known about the age at which this develops. This paper examines levels of affect, depression and anxiety over the full range of alcohol consumption in young adults.
  88. doi Collaborative care for depression and anxiety problems
    Janine Archer
    School of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK
    Cochrane Database Syst Rev 10:CD006525. 2012
    Common mental health problems, such as depression and anxiety, are estimated to affect up to 15% of the UK population at any one time, and health care systems worldwide need to implement interventions to reduce the impact and burden of ..
  89. ncbi Association of perceived medical errors with resident distress and empathy: a prospective longitudinal study
    Colin P West
    Division of General Internal Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    JAMA 296:1071-8. 2006
    ..Medical errors are associated with feelings of distress in physicians, but little is known about the magnitude and direction of these associations...
  90. pmc Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic review
    An Pan
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
    JAMA 306:1241-9. 2011
    Several studies have suggested that depression is associated with an increased risk of stroke; however, the results are inconsistent.
  91. ncbi Burnout and self-reported patient care in an internal medicine residency program
    Tait D Shanafelt
    University of Washington, Veterans Affairs Northwest Health Services Research and Development Center of Excellence, and Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Ann Intern Med 136:358-67. 2002
    ..Burnout is a syndrome of depersonalization, emotional exhaustion, and a sense of low personal accomplishment. Little is known about burnout in residents or its relationship to patient care...
  92. doi Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex
    Shuichi Chiba
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 39:112-9. 2012
    ..We investigated the effects of chronic restraint stress (CRS: 6 hours × 28 days) on anxiety- and depression-like behaviors in rats and on the possible changes in glucocorticoid receptor (GR) expression as well as brain-..
  93. ncbi Review of internet-based prevention and treatment programs for anxiety and depression in children and adolescents
    Alison L Calear
    Centre for Mental Health Research, Australian National University, Canberra, ACT, Australia
    Med J Aust 192:S12-4. 2010
    To identify and describe current internet-based prevention and treatment programs for anxiety and depression in children and adolescents.
  94. pmc Adherence in internet interventions for anxiety and depression
    Helen Christensen
    Centre for Mental Health Research, Australian National University, Canberra ACT 0200, Australia
    J Med Internet Res 11:e13. 2009
    Open access websites which deliver cognitive and behavioral interventions for anxiety and depression are characterised by poor adherence...
  95. pmc Social ties and mental health
    I Kawachi
    The Department of Health and Social Behavior, Harvard Center for Society and Health, 677 Huntington Avenue, Boston, MA 02115, USA
    J Urban Health 78:458-67. 2001
  96. doi Psychosocial factors at work and risk of depression: a systematic review of the epidemiological evidence
    J P E Bonde
    Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, Building 2C, DK 8000 Aarhus C, Denmark
    Occup Environ Med 65:438-45. 2008
    Major depression is a leading cause of psychiatric morbidity and may be influenced by psychosocial factors in the workplace, although evidence so far remains circumstantial...
  97. doi The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling
    J M Bessa
    Life and Health Science Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Mol Psychiatry 14:764-73, 739. 2009
    The mechanisms underlying the initiation/onset of, and the recovery from, depression are still largely unknown; views that neurogenesis in the hippocampus may be important for the pathogenesis and amelioration of depressive symptoms have ..
  98. pmc Enhanced depression care for patients with acute coronary syndrome and persistent depressive symptoms: coronary psychosocial evaluation studies randomized controlled trial
    Karina W Davidson
    Department of Medicine, Columbia University College of Physicians and Surgeons, PH9 Center, 622 W 168th St, Room 948, New York, NY 10032, USA
    Arch Intern Med 170:600-8. 2010
    ..This study was conducted to determine the acceptability and efficacy of enhanced depression treatment in patients with ACS.
  99. ncbi A yoga intervention for young adults with elevated symptoms of depression
    Alison Woolery
    University of California, Los Angeles, USA
    Altern Ther Health Med 10:60-3. 2004
    Yoga teachers and students often report that yoga has an uplifting effect on their moods, but scientific research on yoga and depression is limited.
  100. doi The relation between work-related psychosocial factors and the development of depression
    Bo Netterstrøm
    Clinic of Occupational Medicine, Hillerød Hospital, Helsevej 2, DK 3400 Hillerød, Denmark
    Epidemiol Rev 30:118-32. 2008
    ..criteria: 1) a longitudinal study, 2) exposure to work-related psychosocial factors, 3) the outcome a measure of depression, 4) relevant statistical estimates, and 5) nonduplicated publication...

Research Grants85

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    Abstract Depression is costly and has detrimental effects on disease course in physically ill populations...
  2. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    ..limit dynamic exercise: amputation, paralysis, peripheral vascular disease, cardiopulmonary disorders, and even depression. In addition to decreasing arterial pressure, regular dynamic exercise decreases sympathetic outflow which ..
  3. Multi-targeted Countermeasures against Acute and Delayed Effects of OP Exposure
    John A Butera; Fiscal Year: 2013
    ..cholinergic toxidrome, resulting in seizures, paralysis, mucous secretions, eye irritation, cardiorespiratory depression, GI distress, and eventually, death...
  4. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
    Aberrant norepinephrine [NE] neurotransmission in the human brain is linked to mood disorders, depression, drug addiction and neurodegenerative diseases...
  5. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    According to the World Health Organization depression affects 121 million people worldwide. Chronic stress and thus increased corticotrophin releasing factor (CRF) signaling is indicated as a potential risk factor for depression...
  6. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    ..of posttraumatic stress disorder (PTSD) and chronic postconcussive syndrome, including fatigue, anxiety, depression, irritability, insomnia, and decreased quality of life (QoL), as well as changes in body composition including ..
  7. Neuroimaging abnormalities in major depressive disorder: effect of inflammation
    Jonathan Savitz; Fiscal Year: 2013
    ..Inflammation is hypothesized to contribute to depression by altering the breakdown of tryptophan (TRP), the precursor of serotonin, reducing serotonin levels and ..
  8. Behavioral Activation Therapy for Rural Veterans with Diabetes and Depression
    Aanand Dinkar Naik; Fiscal Year: 2013
    ..phase), HOPE will produce greater improvements in diabetes control (measured by hemoglobin A1c levels) and depression (measured by PHQ-9 scores) than will EUC...
  9. 5-HT transporter function: Interaction of hormones and antidepressants
    Alan Frazer; Fiscal Year: 2013
    ..It is likely that effects of gonadal hormones contribute to the development of MDD (as well as postpartum depression) and this may be part of the reason why MDD is more common in females than in males...
  10. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..Neurosteroids, steroids synthesized de novo in the brain, have been implicated in functions ranging from stress, depression, anxiety, to cognition...
  11. Remodeling Neuronal Chromatin in Mouse Models for Depression
    Schahram Akbarian; Fiscal Year: 2013
    ..characterization of NMDA receptors in hippocampus and other brain regions implicated in the neurobiology of depression. This proposal will explore the antidepressant potential of Setdb1-regulated histone methylation, including the ..
  12. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..In most cases, overactive bladder symptoms are associated with insomnia, anxiety, fatigue, and even depression. Factors predisposing to the development of bladder overactivity and LUTS are poorly understood...
  13. Role of CD44 in experimental Multiple Sclerosis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..prevalence of symptoms among recent Gulf war and other war veterans which include cognitive dysfunction, depression, chronic fatigue, musculoskeletal complaints, post-traumatic stress disorder and respiratory illness...
  14. Neural mechanisms by which chronic stress regulates inflammation in asthma
    Melissa A Rosenkranz; Fiscal Year: 2013
    ..g. depression and anxiety)...
  15. Regulation of AKAP79 Postsynaptic Membrane Targeting
    MARK L DELL'ACQUA; Fiscal Year: 2012
    ..In contrast, induction of long-term depression (LTD) leads to calcineurin-protein phosphatase 2B (CaN) mediated dephosphorylation of PKA phosphorylated GluR1, ..
  16. Efficacy of Yoga for Treatment-Resistant PTSD
    Bessel Van der Kolk; Fiscal Year: 2010
    ..women in the US? Research has demonstrated a close association between trauma exposure and 1) PTSD, anxiety &depression, 2) loss of affect regulation, 3) poor quality of life, and 4) high health care utilization (2, 3)...
  17. Functional Neuroimaging of Individual Differences in Affect and Motivation
    BRIAN JAMES MICKEY; Fiscal Year: 2013
    ..genetics, and mood disorders while characterizing neurobiological mechanisms that underlie genetic risk for depression. Candidate. The candidate's education and training have prepared him well for this project...
  18. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..Abnormalities of the LCNN are thought to contribute to the symptoms of attention deficit hyperactivity disorder, depression, Parkinson's and Alzheimer's diseases, and sleep disorders...
  19. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..The second involves reflex cardiovascular depression during mild gastric distension in ketamine-xylazine anesthetized rats, which appears to inhibit the prevagal ..
  20. Characterization of epsilon-sarcoglycan interacting proteins in mouse brain
    Yuqing Li; Fiscal Year: 2012
    ..We found that the Sgce knockout mice showed myoclonus, motor deficits indicative of dystonia, anxiety, depression, and changes in the dopaminergic and serotonergic systems...
  21. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012 the brain are in areas concerned with memory, learning and mood, parts of the brain that are altered in depression, including post traumatic stress disorder...
  22. Comparative effectiveness of diabetes prevention strategies in women with GDM
    Assiamira Ferrara; Fiscal Year: 2010 women with gestational diabetes (GDM) for improving the following: obesity, hyperglycemia, hypertension and depression in a real-world clinical setting...
  23. Dietary Supplement Creatine for Adolescent Females with SSRI-Resistant Depression
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..Converging lines of evidence suggest that depression is associated with changes in brain energy metabolism that normalize with resolution of a depressive episode...
  24. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    ..Similarly, LTF of SNSA activity and possibly long-term depression (LTD) of parasympathetic nervous system activity (PNSA) could ultimately lead to persistent increases in blood ..
  25. The Role of Astrocytes in Cortical Interneuron Development
    KAREN MULLER SMITH; Fiscal Year: 2013
    ..PV) expressing interneurons, is implicated in severe psychiatric disorders including schizophrenia, bipolar depression, and Tourette syndrome...
  26. Role of TPH2 and 5HT Neuronal Loss in Non-motor Symptoms of Parkinson's
    Donald M Kuhn; Fiscal Year: 2012
    ..light of the fact that approximately 80% of PD patients suffer from co-morbid neuropsychiatric conditions like depression, sleep disorders, anxiety and dementia...
  27. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..Using 2 rat models of chronic psychological stress validated for irritable bowel syndrome and depression, we propose to evaluate 1) whether chronic stress affects visceral adiposity and the expression of neuropeptides ..
  28. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013 applicant): To facilitate the development of a personalized approach to the treatment of patients with major depression, this study is designed to elaborate the clinical and neurobiological phenotype of depressed patients with ..
  29. Role of beta-endorphin in cancer therapy induced fatigue
    David E Fisher; Fiscal Year: 2013
    ..Quantitative rat actimetry measurements revealed major locomotor depression, indicative of severe fatigue, which precisely correlated temporally with 2-endorphin blood elevations...
  30. Effectivenss of a New Non-Invasive Erectile Support System in Aging Populations
    S ALEXANDER WEINSTOCK; Fiscal Year: 2012
    ..This unfortunate but totally natural condition contributes to feelings of insecurity, depression, abandoning relationships, social isolation, and the diminishment of the quality-of-life for both men and their ..
  31. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ..Seasonal changes in human behavioral pathology are also observed in anxiety and depression, migraine headaches, as well as incidence, severity, and mortality of strokes...
  32. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2012
    ..responsible for the characteristic parkinsonian movement disorder, non-motor disabilities including dementia, depression, gastrointestinal dysfunction, and autonomic instability arise from neurodegeneration elsewhere in the central, ..
  33. A Computational Framework for Mapping Long Range Genetic Circuits
    Tolga Tasdizen; Fiscal Year: 2010
    ..system, where dysregulation of circuitry has been implicated in the most devastating mental illnesses, depression, schizophrenia and autism...
  34. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..Psychiatric Disorders such as alcohol and other substance abuse disorders, unipolar depression, bipolar disorder and attention-deficit/hyperactivity disorder (ADHD) are amongst the most significant causes of ..
  35. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    ..The agents currently used to prevent the shiver response produce respiratory depression and typically require patient ventilation...
  36. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    ..significant reductions in quality of life, as well as social stigmatization, increased rates of anxiety and depression, and increased thoughts of suicide...
    Bruce S McEwen; Fiscal Year: 2013
    ..and structural changes do not spontaneously recover, inappropriate neurobehavioral functions, such as anxiety or depression, can persist and become maladaptive...
  38. Fall risk assessment and prevention in elderly with diabetes using wearable techn
    Bor Rong Chen; Fiscal Year: 2012
    ..neuropathy (DPN) frequently exhibit concomitant postural instability that can lead to falls, fracture, depression, anxiety, and decreased quality of life. Individuals with diabetes are 2...
  39. Hiv-1 Infection: Central Serotonergic Activity and its Health Implications
    Adarsh M Kumar; Fiscal Year: 2010
    ..such as that of serotonin (5- hydroxytryptamine, 5-HT) may have a wide range of health implications, including depression and other neuropsychiatric disorders, neurological abnormalities, and neurocognitive impairment...
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    ..In turn, they have spun off separate drug development endeavors directed novel nicotinic receptor ligands for depression, schizophrenia, pain alleviation and nicotine addiction and AChE inhibitor antidotes...
  41. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..with low levels or a lack of estrogens, including decreased sexual motivation, hot flushes, sleep disorders, depression/anxiety, brain and spinal cord trauma, amyotrophic lateral sclerosis, and cognitive dysfunction...
  42. Safety signal learning in Rhesus monkeys following early life stressChallenge Ar
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..Because PTSD has high comorbidity with early life stress and major depression other studies in our group have now shown that patients with early life stress only or major depression only ..
  43. RNA interference therapy for Huntington's disease: studies in non-human primates
    Beverly L Davidson; Fiscal Year: 2010
    ..for other brain disorders in the NHP, such as neuropathic pain, encephalitis, various carcinomas, anxiety and depression. In this work we will test the safety and efficiency of gene therapies designed to treat the fatal neurogenetic ..
  44. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..impact the quality of life of women because they are associated with sleep disturbances resulting in fatigue, depression, irritability, and forgetfulness, as well as acute physical discomfort and negative effects on work...
  45. Implantation of physiologically functional bioengineered innervated IAS construct
    Khalil N Bitar; Fiscal Year: 2010
    ..Individuals who are incontinent may experience anxiety about "accidents," depression, social isolation, and social exclusion. The management of incontinence itself is burdensome...
  46. Serotonin transporter-mediated regulation of neuroendocrine exocytosis
    KEVIN P CURRIE; Fiscal Year: 2013
    ..Genetic variations in SERT are associated with several neuropsychiatric disorders including depression, anxiety, obsessive compulsive disorder, and autism...
  47. Astrocytic Ca2+ Signaling in the Ischemic Penumbra
    Maiken Nedergaard; Fiscal Year: 2011
    ..In specific, we will define the role of adenosine A1 receptors in synaptic depression in the penumbra...
  48. Anxiety development in 5-HT1A autoreceptor knockout mice, interaction with stress
    Rene Hen; Fiscal Year: 2010
    ..antisocial behavior and how the 5-HTT transporter interacts with adverse early adult events to increase risk of depression, our understanding of how early environmental conditions might differentially impact the expression of ..
  49. Epigenetic Regulation of Serotonin:Relevance to HIV and Methamphetamine Abuse
    GREGORY MICHAEL MILLER; Fiscal Year: 2012 HIV infection, methamphetamine dependence and consequent changes in the serotonin system that correlate to depression, stress and disruption of the hypothalamic-pituitary-adrenal axis is critical to designing new preventative and ..
  50. RidCancerPain Intervention in a Hispanic Population Along the US-Mexico Border
    KRISTYNIA MARIE contact ROBINSON; Fiscal Year: 2010
    ..increase the likelihood of minorities suffering from the costly consequences of uncontrolled pain such as depression, sleep disorders, lost work productivity, and impaired relationships with family and friends (American Pain ..
  51. Multiple Mechanisms of Nasal Chemoreception
    Diego Restrepo; Fiscal Year: 2012
    ..of the sense of smell are encountered in diseases such as Alzheimer's (Doty, 1991;Rawson, 2000), bipolar depression (Hahn et al., 2005) and schizophrenia (Turetsky et al., 2003)...
  52. Interactions Between Depression, Neuroinflammation and Glycogen Synthase Kinase-3
    Eleonore Beurel; Fiscal Year: 2011 applicant): Accumulating evidence shows inflammation strongly influences the development and treatment of depression, a debilitating disease with a lifetime incidence of ~20%...
  53. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2009
    ..condition characterized by a syndrome of recurrent abdominal pain, diarrhea and psychological conditions such as depression and anxiety...
  54. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..An understanding of the fetal mechanisms associated with sex differences in MOD will have etiologic imolications and imoortance for the development of sex-specific treatments and prevention of MOD. ..
  55. Derivation of cerebral cortical GABAergic interneurons from human iPS cells
    Lorenz P Studer; Fiscal Year: 2010 a variety of major neuropsychiatric illnesses, including schizophrenia, autism, anxiety, and epilepsy (where depression is a major source of morbidity)...
  56. Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human Neurons
    JEN PAN; Fiscal Year: 2013
    ..Individuals with bipolar disorder suffer from recurrent episodes of mania and depression, and current bipolar treatments, such as lithium, are often ineffective in many patients...
  57. Regulation of alpha2A-adrenergic receptor signaling and trafficking by spinophili
    Qin Wang; Fiscal Year: 2013
    ..for pathogenesis and a valuable target for treatment of a variety of diseases including ADHD, hypertension and depression. To date, the endogenous mechanisms whereby ?2AAR functions are regulated at the molecular and cellular levels ..
  58. Postpartum Depression: Role of Sleep &Genetic Risk in Postpartum Mood Disorders
    Katherine M Sharkey; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Postpartum depression is the most common complication of childbirth;it has been linked to morbidity and mortality (including suicide) ..
  59. Abdominal Symptom Phenotypes: Pathways to New Biomarkers
    Robert Shulman; Fiscal Year: 2010
    ..There are well-recognized associations between IBS and other conditions (fibromyalgia, headache) and symptoms (depression, fatigue, insomnia)...
  60. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..Deficits in serotonin appear to precipitate depression and anxiety disorders more frequently in women, but deficits in serotonin in men often underlie irritability, ..
  61. Neuroendocrine Contribution to Behavior &Cognition in the Female Lifespan
    C NEILL NEILL EPPERSON; Fiscal Year: 2013 inform our investigations of the pathogenesis of premenstrual dysphoric disorder (PMDD), postnatal depression (PPD), and perimenopausal mood and cognitive changes...
  62. Optic Nerve Aging and Glaucoma
    Thasarat Vajaranant; Fiscal Year: 2013
    ..acuity, can lead to significant functional visual impairment and substantial secondary risks to health including depression, falls and motor vehicle accidents...
  63. Genomics of RNA Editing: Identification and Regulation
    Jin Billy Li; Fiscal Year: 2013
    ..RNA editing has been implicated in human neurological diseases such as amyotrophic lateral sclerosis, epilepsy, depression, suicide, glioma, and cancers, and may have contributed to the evolutionary development of human neurobiology ..
  64. Sleep Patterns and Depression in Mothers and Fathers of Twins
    ELIZABETH DAMATO; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Sleep Patterns and Depression in Mothers and Fathers of Twins The demands of early parenthood and their impact on the ability to obtain rest and sleep are exponentially high for parents ..
  65. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010 applicant): The objective of the project is to validate an experimental model of co-morbidity between depression and temporal lobe epilepsy (TLE), and to establish the mechanistic connection between the two states...
  66. Adapting Exercise Treatment for Depression to Adolescents: A Pilot Study
    PHILIPPE WEINTRAUB; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Adolescent depression is a major public health problem in the United States and throughout the world. Major depressive disorder (MDD) in adolescence is common with point prevalence rates of 3% to 9%...
  67. Preventing Depression in People with Epilepsy: An Extension of Project UPLIFT
    Nancy J Thompson; Fiscal Year: 2010
    ..It describes an intervention to prevent depression, a significant chronic disease, among a specific disparity population: people with epilepsy...
  68. A Comprehensive Intervention for Diabetes and Comorbid Depression in Primary Care
    Madhukar H Trivedi; Fiscal Year: 2010
    ..Despite early evidence that successful treatment of depression is associated with improvements in glycemic control, two of every three cases depression are left untreated by ..
  69. Risk for New onset of Depression in Perimenopausal Women
    Daniel Cramer; Fiscal Year: 2009
    Several epidemiological studies have shown that women, compared to men, are at a substantially greater risk of depression beginning in adolescence and continuing through their entire life...
  70. The Epidemiology of Hospitalized Postpartum Depression
    David Savitz; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The epidemiological characteristics of severe postpartum depression requiring hospitalization have not been described...
    Maurizio Fava; Fiscal Year: 2011
    b>Depression is one of the most common and serious disorders treated by mental health practitioners...
  72. Biomarkers for Outcomes In Late-life Depression (BOLD)
    Ian A Cook; Fiscal Year: 2010
    ..Challenge Topic 03-MH-101: Biomarkers in mental disorders, in Project BOLD (Biomarkers for Outcomes In Late-life Depression)...
    JAY WEISS; Fiscal Year: 2001 which noradrenergic neurons in the brain influence dopaminergic neurons to produce behavioral changes seen in depression. These studies address an important issue related to the neurobiology of depression; namely, that while much ..
  74. Anticipating reward & threat: A test of biobehavioral processes in MDD vs anxiety
    STEWART AARON SHANKMAN; Fiscal Year: 2010
    ..This study seeks to evaluate two tendencies that have been proposed to underlie depression and anxiety, respectively - low sensitivity to appetitive stimuli and high sensitivity to aversive stimuli...
  75. Calcium for Prevention of Postpartum Depression
    Daniel Hatton; Fiscal Year: 2004
    Post-partum depression causes maternal suffering and can have a lasting negative influence on the child's cognitive and emotional development...
  76. Cost Effectiveness of a Home Support Program for Depression in Black Elders
    Laura N Gitlin; Fiscal Year: 2010
    ..a cost effectiveness analysis of our currently funded randomized controlled trial (NIMH R01MH079814) "Treating Depression in Older African Americans") that tests a novel 10- session home-based intervention to treat depression in older ..
  77. Effects of Psychopathology on Prefrontal Cortical Functioning During Goal-Directe
    Sharon L Thompson Schill; Fiscal Year: 2010
    ..psychology has revealed a similarly suboptimal cognitive style in the majority of patients diagnosed with depression, as indicated by pronounced difficulties in decision-making, perseverations on, particularly negative, ..
  78. Efficacy of an Exercise Intervention for the Prevention of PostPartum Depression
    Beth A Lewis; Fiscal Year: 2010
    ..Recent estimates indicate that approximately 10-15 percent of women giving birth experience depression during the postpartum period (Dietz et al., 2007;Gaven et al., 2005)...
  79. Systems of Care for New Moms: Integrating Depression Treatment
    Luis H Zayas; Fiscal Year: 2010
    Maternal depression in the postpartum period is a significant public health matter, particularly among poor urban minority women with limited access to mental health services. Through research we know how to treat depression...
  80. Maternal depression, family food behavior, and child nutritional health
    KAREN P MCCURDY; Fiscal Year: 2010
    ..Low-income women are at increased risk for depression and the effects of maternal depression on parenting behaviors (i.e...
  81. Patient Centered Depression Care for African-Americans
    Lisa Cooper; Fiscal Year: 2007
    ..However, African Americans with depression are just as likely as whites to receive care in primary care settings...
  82. Anxiety and Depression among Elderly Public Housing Residents
    Adam Simning; Fiscal Year: 2009
    DESCRIPTION (provided by the applicant): Background: Anxiety and depression in socioeconomically disadvantaged older adults frequently go unrecognized and untreated...
    Rachel Manber; Fiscal Year: 2006
    ..the proposed randomized controlled study is to assess the efficacy and effectiveness of acupuncture treatment of depression during pregnancy...
  84. Depression in Alzheimer's Disease-II
    Curtis Meinert; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Depression in the context of Alzheimer's disease (AD) is a significant public health problem with serious adverse consequences for patients and their caregivers...
    Pingfu Feng; Fiscal Year: 2001
    ..long-term goal of the proposed work is to determine brain processes involved in the pathogenesis of endogenous depression (ED)...