behavioral symptoms

Summary

Summary: Observable manifestations of impaired psychological functioning.

Top Publications

  1. ncbi Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease
    Paul Hollingworth
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    J Am Geriatr Soc 54:1348-54. 2006
  2. ncbi [Assessment of behavioural and psychotic symptoms and functional status of nursing home residents with a diagnosis of dementia]
    Leszek Bidzan
    Klinika Psychiatrii Rozwojowej, Zaburzeń Psychotycznych i Wieku Podeszlego AM w Gdańsku
    Psychiatr Pol 40:833-43. 2006
  3. ncbi The course of psychiatric and behavioral symptoms and the use of psychotropic medication in patients with dementia in Norwegian nursing homes--a 12-month follow-up study
    Geir Selbaek
    Research Centre for Old Age Psychiatric Research, Innlandet Hospital Trust, Ottestad, Norway
    Am J Geriatr Psychiatry 16:528-36. 2008
  4. ncbi Behavioral problems in dementia: a factor analysis of the neuropsychiatric inventory
    Pauline Aalten
    Brain and Behavior Institute, University of Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 15:99-105. 2003
  5. ncbi Formal caregiver burden in dementia: impact of behavioral and psychological symptoms of dementia and activities of daily living
    Yuki Miyamoto
    Department of Psychiatric Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Geriatr Nurs 31:246-53. 2010
  6. ncbi The persistence of neuropsychiatric symptoms in dementia: the Cache County Study
    Martin Steinberg
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 19:19-26. 2004
  7. pmc Mania-like behavior induced by disruption of CLOCK
    Kole Roybal
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 104:6406-11. 2007
  8. pmc Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania
    G Shaltiel
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 13:858-72. 2008
  9. ncbi Prevalence and correlates of psychotropic drug use in Dutch nursing-home patients with dementia
    Renate M Nijk
    Center for Family Medicine, Geriatric Care and Public Health, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands
    Int Psychogeriatr 21:485-93. 2009
  10. ncbi Epidemiology-driven neurodevelopmental animal models of schizophrenia
    Urs Meyer
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology ETH Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Prog Neurobiol 90:285-326. 2010

Detail Information

Publications223 found, 100 shown here

  1. ncbi Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease
    Paul Hollingworth
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, United Kingdom
    J Am Geriatr Soc 54:1348-54. 2006
    ..To investigate behavioral components of Alzheimer's disease (AD) and to analyze behavioral components in relation to disease severity, apolipoprotein E genotype (APOE), sex, years of education, age at onset, and cognitive impairment...
  2. ncbi [Assessment of behavioural and psychotic symptoms and functional status of nursing home residents with a diagnosis of dementia]
    Leszek Bidzan
    Klinika Psychiatrii Rozwojowej, Zaburzeń Psychotycznych i Wieku Podeszlego AM w Gdańsku
    Psychiatr Pol 40:833-43. 2006
    ..This study sought to determine the relationship between behavioural and psychopathological disturbance and the functional status of dementia patients...
  3. ncbi The course of psychiatric and behavioral symptoms and the use of psychotropic medication in patients with dementia in Norwegian nursing homes--a 12-month follow-up study
    Geir Selbaek
    Research Centre for Old Age Psychiatric Research, Innlandet Hospital Trust, Ottestad, Norway
    Am J Geriatr Psychiatry 16:528-36. 2008
    ..This study investigates the natural course of neuropsychiatric symptoms and the concomitant use of psychotropic medication among a large and representative sample of nursing-home patients with dementia...
  4. ncbi Behavioral problems in dementia: a factor analysis of the neuropsychiatric inventory
    Pauline Aalten
    Brain and Behavior Institute, University of Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 15:99-105. 2003
    ..Anxiety was regarded as a separate symptom. The subsyndrome mood/apathy was the most common, occurring in almost 80% of the patients, versus psychosis and hyperactivity, which occurred in 37 and 60% of the patients, respectively...
  5. ncbi Formal caregiver burden in dementia: impact of behavioral and psychological symptoms of dementia and activities of daily living
    Yuki Miyamoto
    Department of Psychiatric Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Geriatr Nurs 31:246-53. 2010
    ..These results illustrate the various characteristics of the burdens on staff members compared with those faced by individuals who provide informal care...
  6. ncbi The persistence of neuropsychiatric symptoms in dementia: the Cache County Study
    Martin Steinberg
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 19:19-26. 2004
    ..To estimate the 18-month persistence of neuropsychiatric symptoms in dementia in a population-based sample, and to compare the severity of neuropsychiatric symptoms at baseline to the severity at 18-month follow-up...
  7. pmc Mania-like behavior induced by disruption of CLOCK
    Kole Roybal
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 104:6406-11. 2007
    ..These findings establish the Clock mutant mice as a previously unrecognized model of human mania and reveal an important role for CLOCK in the dopaminergic system in regulating behavior and mood...
  8. pmc Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania
    G Shaltiel
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 13:858-72. 2008
    ..and behavioral results suggest a unique role for GluR6 in controlling abnormalities related to the behavioral symptoms of mania, such as hyperactivity or psychomotor agitation, aggressiveness, driven or increased goal-directed ..
  9. ncbi Prevalence and correlates of psychotropic drug use in Dutch nursing-home patients with dementia
    Renate M Nijk
    Center for Family Medicine, Geriatric Care and Public Health, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands
    Int Psychogeriatr 21:485-93. 2009
    ..The aim of this study was to determine the prevalence and correlates of psychotropic drug use in Dutch nursing home patients with dementia...
  10. ncbi Epidemiology-driven neurodevelopmental animal models of schizophrenia
    Urs Meyer
    Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology ETH Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
    Prog Neurobiol 90:285-326. 2010
    ....
  11. pmc What are the barriers to performing nonpharmacological interventions for behavioral symptoms in the nursing home?
    Jiska Cohen-Mansfield
    Research Institute on Aging of Charles E Smith Life Communities, Rockville, MD 20852, USA
    J Am Med Dir Assoc 13:400-5. 2012
    b>Behavioral symptoms are common in persons with dementia, and nonpharmacological interventions are recommended as the first line of therapy. We describe barriers to conducting nonpharmacological interventions for behavioral symptoms.
  12. ncbi Cognitive and behavioral impairment in traumatic brain injury related to outcome and return to work
    Marieke R Benedictus
    Department of Neuropsychology, University and Medical Center Groningen, University of Groningen, The Netherlands
    Arch Phys Med Rehabil 91:1436-41. 2010
    ..To evaluate the cognitive and behavioral disturbances related to return to work (RTW) in patients with traumatic brain injury (TBI) with the application of a differentiated outcome scale...
  13. ncbi Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice
    Edward C Stack
    Geriatric Research Education and Clinical Center, Bedford Veterans Administration Medical Center, Bedford, Massachusetts 01730, USA
    J Comp Neurol 490:354-70. 2005
    ....
  14. pmc Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington's disease
    Gehan El-Akabawy
    Department of Neuroscience, King s College London, Institute of Psychiatry, London, SE5 9NU, United Kingdom
    BMC Neurosci 13:97. 2012
    ..Genetically modified animals should provide a more accurate representation of human HD, as they emulate the genetic basis of its etiology...
  15. ncbi Do atypical antipsychotics cause stroke?
    Nathan Herrmann
    Division of Geriatric Psychiatry, University of Toronto, Toronto, Ontario, Canada
    CNS Drugs 19:91-103. 2005
    ..At the present time, this association is another factor that clinicians should consider when weighing the risks and benefits of treating behavioural and psychological disturbances in elderly dementia patients...
  16. ncbi Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients
    Bruce G Pollock
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 159:460-5. 2002
    ....
  17. ncbi Improvement in behavioral symptoms and advance of activity acrophase after short-term bright light treatment in severe dementia
    Arvid Skjerve
    Olaviken Treatment Center, University of Bergen, Bergen, Norway
    Psychiatry Clin Neurosci 58:343-7. 2004
    ..Two rating scales of behavioral symptoms in dementia were used as outcome measures: Cohen-Mansfield Agitation Inventory (CMAI) and Behavior ..
  18. ncbi Early behavioral symptoms and course of Alzheimer's disease
    M F Weiner
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
    Acta Psychiatr Scand 111:367-71. 2005
    To determine if behavioral symptoms detected at initial evaluation relate to cognitive or functional status or survival time in Alzheimer's disease (AD) patients...
  19. ncbi The need-driven dementia-compromised behavior model-- a framework for understanding the behavioral symptoms of dementia
    A L Whall
    Aging Ment Health 8:106-8. 2004
  20. ncbi A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients
    Koh Iwasaki
    Department of Geriatrics and Complementary Medicine, Graduate School of Medicine, Tohoku University, Sendai City, Japan
    J Clin Psychiatry 66:248-52. 2005
    ....
  21. ncbi A randomized, double-blind, placebo-controlled study of aripiprazole for the treatment of psychosis in nursing home patients with Alzheimer disease
    Joel E Streim
    Section on Geriatric Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3309, USA
    Am J Geriatr Psychiatry 16:537-50. 2008
    ..To evaluate the efficacy and safety of aripiprazole treatment for psychotic symptoms associated with Alzheimer disease (AD)...
  22. pmc Pharmacologic treatments for the behavioral symptoms associated with autism spectrum disorders across the lifespan
    Carolyn A Doyle
    Department of Psychiatry, Harvard Medical School Lurie Center for Autism, Massachusetts General Hospital, Boston, MA, USA
    Dialogues Clin Neurosci 14:263-79. 2012
    This review outlines pharmacologic treatments for the behavioral symptoms associated with autism spectrum disorders (ASDs) in children, adolescents, and adults...
  23. pmc Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates
    G Zamboni
    Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, NIH, Bldg 10, Room 7D43, MSC 1440, Bethesda, MD 20892 1440, USA
    Neurology 71:736-42. 2008
    ..Two main behavioral abnormalities have been described: apathy and disinhibition, but their neuroanatomical correlates remain underspecified...
  24. pmc Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression
    Lucy Y Wang
    VA Northwest Network Mental Illness Research, Education, and Clinical Center MIRECC, Seattle, WA 98115, USA
    Am J Geriatr Psychiatry 17:744-51. 2009
    ..This pilot study examined the efficacy and tolerability of prazosin for behavioral symptoms in patients with agitation/aggression in AD.
  25. pmc Serotonin transporter triallelic genotype and response to citalopram and risperidone in dementia with behavioral symptoms
    Alexandre Y Dombrovski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Advanced Center for Interventions and Services Research in Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Int Clin Psychopharmacol 25:37-45. 2010
    The risk/benefit ratio of pharmacotherapy for behavioral symptoms of dementia is questionable: second-generation antipsychotics are poorly tolerated, and the efficacy of alternative treatments, for example, selective serotonin-reuptake ..
  26. ncbi Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes
    Harumi Jyonouchi
    Division of Allergy Immunology and Infection Diseases, Department of Pediatrics, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07101 1709, USA
    J Neuroimmunol 238:73-80. 2011
    ..and transcript profiles of peripheral blood monocytes were studied in ASD children who exhibit fluctuating behavioral symptoms following infection and other immune insults (ASD/Inf, N=30)...
  27. pmc Behavioral symptoms in community-dwelling elderly Nigerians with dementia, mild cognitive impairment, and normal cognition
    Olusegun Baiyewu
    Department of Psychiatry, College of Medicine, University of Ibadan, Nigeria
    Int J Geriatr Psychiatry 27:931-9. 2012
    ..Few studies have examined the neuropsychiatric status of patients with dementia and cognitive impairment in the developing world despite the fact that current demographic trends suggest an urgent need for such studies...
  28. ncbi Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease
    Stefan Van der Mussele
    Reference Center for Biological Markers of Dementia BIODEM, Laboratory of Neurochemistry and Behavior, Institute Born Bunge, University of Antwerp, Antwerp, Belgium
    Int J Geriatr Psychiatry 28:947-58. 2013
    ....
  29. ncbi Behavioral symptoms in residential care/assisted living facilities: prevalence, risk factors, and medication management
    Ann L Gruber-Baldini
    Division of Gerontology, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Am Geriatr Soc 52:1610-7. 2004
    To examine the prevalence, correlates, and medication management of behavioral symptoms in elderly people living in residential care/assisted living (RC/AL) facilities.
  30. ncbi The prevalence of psychiatric symptoms and behavioural disturbances and the use of psychotropic drugs in Norwegian nursing homes
    Geir Selbaek
    Research Centre for Old Age Psychiatric Research, Innlandet Hospital Trust, Ottestad, Norway
    Int J Geriatr Psychiatry 22:843-9. 2007
    ..Psychiatric and behavioural symptoms in dementia are associated with a range of negative outcomes, including institutional placement and the widespread use of psychotropic drugs in spite of limited evidence for their efficacy...
  31. pmc Implications of hepatitis C virus infection for behavioral symptoms and activities of daily living
    Carolina Posada
    San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    J Clin Exp Neuropsychol 32:637-44. 2010
    ..These results show that a subset of HCV-infected individuals report clinically elevated behavioral symptoms. Clinical implications for the assessment and management of elevated behavioral symptoms in HCV are ..
  32. pmc Difficulties in detecting behavioral symptoms of frontotemporal lobar degeneration across cultures
    John D Papatriantafyllou
    Memory and Cognitive Disorders Clinic, Neurology Department, General Hospital of Athens G Gennimatas, National University of Athens, Athens, Greece
    Alzheimer Dis Assoc Disord 23:77-81. 2009
    ..Patients with FTD in Greece and Turkey are diagnosed later in the disease, presumably because their behavioral symptoms are not easily detected by the medical system in these countries...
  33. ncbi Pharmacological management of behavioural and psychological disturbance in dementia
    Mervat N Kozman
    Department of Adult Psychiatry, Briary Wing, Harrogate General District Hospital, Lancaster Park Road, Harrogate, UK
    Hum Psychopharmacol 21:1-12. 2006
    ..The risks and benefits of individual treatments are discussed and the relatively poor evidence base and need for further research is highlighted...
  34. ncbi Dose dependent effect of APOE epsilon4 on behavioral symptoms in frontal lobe dementia
    Sebastiaan Engelborghs
    Department of Neurology and Memory Clinic, Middelheim General Hospital, ZNA, Antwerp, Belgium
    Neurobiol Aging 27:285-92. 2006
    ..In conclusion, APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE epsilon4 with aggression (FTD) and of APOE epsilon2 with delusions (PDD/DLB)...
  35. ncbi Cognition and behaviour are independent and heterogeneous dimensions in Alzheimer's disease
    Gianfranco Spalletta
    Department of Neuroscience, University of Tor Vergata, Rome, Italy
    J Neurol 251:688-95. 2004
    ..In conclusion, many cognitive and behavioural syndromes exist in patients with AD. However, the results of this study suggest that cognition and behaviour are independent dimensions...
  36. pmc Behavioral symptoms in patients with breast cancer and survivors
    Julienne E Bower
    University of California, Los Angeles, Department of Psychology, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    J Clin Oncol 26:768-77. 2008
    b>Behavioral symptoms are a common adverse effect of breast cancer diagnosis and treatment and include disturbances in energy, sleep, mood, and cognition...
  37. ncbi Specific psychological and behavioral symptoms of depression in patients with dementia
    Annie Prado-Jean
    CMRR The Limousin Center for Memory Research, University of Limoges, France
    Int J Geriatr Psychiatry 25:1065-72. 2010
    ..One-third of persons with dementia have depressive symptoms, and concomitant BPSD are very likely...
  38. ncbi Neuropsychiatric manifestations in mild cognitive impairment: a systematic review of the literature
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, USA
    Dement Geriatr Cogn Disord 25:115-26. 2008
    ..MCI is an important risk state for dementia. Neuropsychiatric symptoms may be present in MCI...
  39. ncbi A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia
    Katsuyoshi Mizukami
    Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Int J Neuropsychopharmacol 12:191-9. 2009
    ..TJ-54 did not show any effect on either cognitive function or ADL. No serious adverse reactions were observed. The present study suggests that TJ-54 is an effective and well-tolerated treatment for patients with BPSD...
  40. ncbi Cell-based treatments for huntington's disease
    Stephen B Dunnett
    Brain Repair Group, Schools of Biosciences and Medicine, Cardiff University, Cardiff, Wales, UK
    Int Rev Neurobiol 98:483-508. 2011
    ....
  41. ncbi Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer's disease
    Kazunori Okahara
    Keimei Memorial Hospital, 762 Iwachino, Kunitomi cho, Higashimorokata, Miyazaki 880 1111, Japan Shonan Hospital, 1 Shimokubomachi, oosumi cho, Soo, Kagoshima 899 8106, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:532-6. 2010
    ..No adverse reactions were noted in either group. The results of this study showed that YKS is safe and effective in the treatment of BPSD in AD patients...
  42. ncbi Neurotransmitter deficits in behavioural and psychological symptoms of Alzheimer's disease
    Alessia Lanari
    Dipartimento di Neuroscienze, Universita di Perugia, Perugia, Italy
    Mech Ageing Dev 127:158-65. 2006
    ..On the site of psychotropic drugs, atypical or novel antipsychotics represent the reference drugs for treating BPSD, whereas classic antipsychotic drugs for their profile and the potential side effects should be avoided...
  43. ncbi Differential impact of severity of drug use on frontal behavioral symptoms
    Antonio Verdejo-Garcia
    Departamento de Personalidad, Evaluacion y Tratamiento Psicologico, Universidad de Granada, Campus de Cartuja s n, 18071 Granada, Spain
    Addict Behav 31:1373-82. 2006
    ..using cognitive measures and support the notion that severity of substance use significantly affects behavioral symptoms associated with PFC systems functioning...
  44. ncbi A 6-month observational study of the relationship between weight loss and behavioral symptoms in institutionalized Alzheimer's disease subjects
    Heidi K White
    Center for the Study of Aging and Human Development, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    J Am Med Dir Assoc 5:89-97. 2004
    Weight loss is a common occurrence in Alzheimer's disease (AD). This study was undertaken to investigate the relationship between weight loss and behavioral symptoms in institutionalized AD subjects.
  45. pmc Effect of pioglitazone treatment on behavioral symptoms in autistic children
    Marvin Boris
    Woodbury, New York 11797, USA
    J Neuroinflammation 4:3. 2007
    ..We therefore tested the safety and therapeutic potential of oral pioglitazone in a small cohort of children with diagnosed autism...
  46. ncbi An individualized psychosocial approach for "treatment resistant" behavioral symptoms of dementia among aged care residents
    Tanya E Davison
    School of Psychology, Deakin University, Burwood, Victoria, Australia
    Int Psychogeriatr 19:859-73. 2007
    b>Behavioral symptoms of dementia are common among residents in mainstream aged care settings, and have a substantial impact on residents and professional caregivers...
  47. ncbi Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia
    Tadaaki Kawanabe
    Department of Neurology, Juntendo Urayasu Hospital, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:284-7. 2010
    ....
  48. ncbi Urinary incontinence and behavioral symptoms are independent risk factors for recurrent and injurious falls, respectively, among residents in long-term care facilities
    Jun Hasegawa
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tusruma cho, Showa Ku, Nagoya 466 8550, Japan
    Arch Gerontol Geriatr 50:77-81. 2010
    Numerous risk factors of falls, including urinary incontinence and behavioral symptoms have been identified among elderly people in long-term care settings...
  49. pmc Behavioral disorders in the frontal and temporal variants of frontotemporal dementia
    W Liu
    Department of Neurology, University of California at San Francisco, USA
    Neurology 62:742-8. 2004
    ..To compare the behavioral features and to investigate the neuroanatomic correlates of behavioral dysfunction in anatomically defined temporal and frontal variants of frontotemporal dementia (tvFTD and fvFTD)...
  50. ncbi Behavioral features in semantic dementia vs other forms of progressive aphasias
    H J Rosen
    University of California at San Francisco Department of Neurology, San Francisco, CA 94143 1207, USA
    Neurology 67:1752-6. 2006
    ..To compare the behavioral profiles in different variants of primary progressive aphasia (PPA)...
  51. ncbi Olanzapine as a possible treatment of behavioral symptoms in vascular dementia: risks of cerebrovascular events. A controlled, open-label study
    Rita Moretti
    Dip di Medicina Clinica e Neurologia, UCO di Neurologia, Universita degli Studi di Trieste, Ospedale di Cattinara, 34149 Trieste, Italy
    J Neurol 252:1186-93. 2005
    ..These behavioral symptoms can be a major cause of stress, anxiety and concern for caregivers...
  52. ncbi Non-pharmacological and pharmacological treatment of the cognitive and behavioral symptoms of Alzheimer disease
    Ronald F Zec
    Center for Alzheimer Disease and Related Disorders, Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    NeuroRehabilitation 23:425-38. 2008
    This paper discusses the various pharmacological and behavioral treatments for the cognitive, emotional, and behavioral symptoms of Alzheimer disease (AD)...
  53. ncbi Donepezil for the treatment of behavioral symptoms in patients with Alzheimer's disease
    Diana Paleacu
    Neurological Service and Memory Clinic, Abarbanel Mental Health Center, Sackler School of Medicine, Tel Aviv University, Bat Yam, Israel
    Clin Neuropharmacol 25:313-7. 2002
    ..Acetylcholinesterase inhibitors should be considered for the treatment of BPSD before neuroleptic treatment is instituted in AD patients with low levels of irritability and agitation...
  54. ncbi Behavioral symptoms in mild cognitive impairment
    H Feldman
    Division of Neurology, University of British Columbia, Vancouver Hospital and Health Sciences Center, Vancouver, British Columbia, Canada
    Neurology 62:1199-201. 2004
    ..NPI+ subjects had significantly greater impairment on global, cognitive, and functional scores than NPI- subjects. The presence of neuropsychiatric symptoms appears to be a marker of MCI severity...
  55. ncbi Rasagiline-associated motor improvement in PD occurs without worsening of cognitive and behavioral symptoms
    L Elmer
    Medical College of Ohio, Department of Neurology, 3120 Glendale Ave, Toledo, OH 43614, USA
    J Neurol Sci 248:78-83. 2006
    ....
  56. ncbi Premorbid personality traits in Alzheimer's disease: do they predispose to noncognitive behavioral symptoms?
    W Meins
    Department of Geriatric Medicine, Albertinen Hospital, Hamburg, Germany
    Int Psychogeriatr 10:369-78. 1998
    ..Premorbid personality traits may indeed predispose to subsequent noncognitive symptoms in AD...
  57. ncbi Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: an open-label trial
    Ken Nagata
    Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan
    Phytomedicine 19:524-8. 2012
    ..There was no adverse effect during the treatment period. The present results suggest that yokukansan is beneficial for the treatment of BPSD in VaD patients...
  58. ncbi Psychotropic medication use for behavioral symptoms of dementia
    Philip S Wang
    Department of Psychiatry, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Curr Neurol Neurosci Rep 6:490-5. 2006
    ..psychotropic medications are currently approved by the US Food and Drug Administration (FDA) to treat such behavioral symptoms, a variety of drug classes are commonly used for these purposes...
  59. ncbi A longitudinal study of behavior in frontotemporal dementia and primary progressive aphasia
    Cecile A Marczinski
    Department of Clinical Neurological Sciences, St Joseph s Hospital, University of Western Ontario, London, Ontario, Canada
    Cogn Behav Neurol 17:185-90. 2004
    ....
  60. ncbi Increased levels of glutamate in the central nervous system are associated with behavioral symptoms in experimental malaria
    A S Miranda
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
    Braz J Med Biol Res 43:1173-7. 2010
    ..In the present study, we investigated the involvement of glutamate in the behavioral symptoms of CM. Seventeen female C57BL/6 mice (20-25 g) aged 6-8 weeks were infected with P...
  61. ncbi Assessment and treatment of nursing home residents with depression or behavioral symptoms associated with dementia: a review of the literature
    Mark Snowden
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    J Am Geriatr Soc 51:1305-17. 2003
    Depression and the behavioral symptoms associated with dementia remain two of the most significant mental health issues for nursing home residents...
  62. pmc Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP)
    Yi lang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, Connecticut, USA
    Am J Addict 18:339-45. 2009
    Chronic use of cocaine is associated with a variety of behavioral symptoms. The current report describes the assessment of cocaine-related behavioral symptoms (CRB) using the Scale for Assessment of Positive Symptoms of Cocaine-Induced ..
  63. ncbi Long-term efficacy of olanzapine in the control of psychotic and behavioral symptoms in nursing home patients with Alzheimer's dementia
    J S Street
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Int J Geriatr Psychiatry 16:S62-70. 2001
    ..CONCLUSIONS: Low-dose olanzapine appears to be effective and well tolerated for treatment of behavioral disturbances and psychotic symptoms due to AD in elderly patients...
  64. ncbi Pharmacologic treatment of behavioral symptoms in autism and pervasive developmental disorders
    Robert L Findling
    Division of Child and Adolescent Psychiatry, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Psychiatry 66:26-31. 2005
    ..Although there is currently no pharmacologic cure for the core features of PDDs, some of the behavioral symptoms may be treated pharmacologically...
  65. ncbi Behavioral symptoms associated with Huntington's disease
    Karen E Anderson
    Department of Neurology, Movement Disorders Division, University of Maryland, School of Medicine, Baltimore, Maryland, USA
    Adv Neurol 96:197-208. 2005
    ..These behavioral symptoms contribute to morbidity and augment what is often an overwhelming caregiver burden...
  66. ncbi Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study
    Constantine G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    JAMA 288:1475-83. 2002
    ..Dementia and MCI are associated with neuropsychiatric symptoms in clinical samples. Only 2 population-based studies exist of the prevalence of these symptoms in dementia, and none exist for MCI...
  67. ncbi Relationship between behavioural and psychological symptoms of dementia and cognition in Alzheimer's disease
    John M Starr
    Geriatric Medicine Unit, Royal Victoria Hospital, Edinburgh, UK
    Dement Geriatr Cogn Disord 24:343-7. 2007
    ..Behavioural and psychological symptoms of dementia (BPSDs) are common. It is unclear whether associations are stronger with the absolute cognitive level or that relative to premorbid mental ability...
  68. ncbi Efficacy of memantine on behavioral and psychological symptoms related to dementia: a systematic meta-analysis
    Ian D Maidment
    Kent and Medway NHS and Social Care Partnership Trust, Kent Institute of Medicine and Health Studies, University of Kent, Kent, England
    Ann Pharmacother 42:32-8. 2008
    ..The behavioral and psychological symptoms related to dementia (BPSD) are difficult to manage and are associated with adverse patient outcomes...
  69. ncbi Role of 5HT 2A and 5HT 2C polymorphisms in behavioural and psychological symptoms of Alzheimer's disease
    Antonia L Pritchard
    Department of Human Genetics, G Floor CBCRC Building, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane 4006, Australia
    Neurobiol Aging 29:341-7. 2008
    ..Polymorphisms within serotonin receptors 5HT(2A) and 5HT(2C) have been previously investigated in a few interesting studies reviewed here, however, their role remains unclear...
  70. ncbi Long-term effects of risperidone versus haloperidol on verbal memory, attention, and symptomatology in schizophrenia
    Sophie Rémillard
    Cognitive Science Institute, Universite du Quebec a Montreal, Montreal, Canada
    J Int Neuropsychol Soc 14:110-8. 2008
    ..Neither conventional nor atypical neuroleptic medications improved neurocognitive functioning over a 12-month follow-up, suggesting that psychopathological improvement under risperidone is independent of cognitive function...
  71. ncbi The progression of cognition, psychiatric symptoms, and functional abilities in dementia with Lewy bodies and Alzheimer disease
    Karina Stavitsky
    Gertrude H Sergievsky Center and Department of Neurology, Columbia University Medical Center, New York, NY, USA
    Arch Neurol 63:1450-6. 2006
    ..Although dementia with Lewy bodies (DLB) may be one of most common forms of dementia, relatively little is known about its cognitive and functional course...
  72. ncbi Study of behavioral and psychological symptoms of dementia in Taiwan
    Jong Ling Fuh
    Neurological Institute, Veterans General Hospital Taipei, Taiwan
    Acta Neurol Taiwan 15:154-60. 2006
    ....
  73. ncbi Compulsive urination as a presenting symptom of frontotemporal dementia
    A B Porter
    Eur J Neurol 14:e16-7. 2007
  74. ncbi Pharmacotherapy for behavioral and psychological symptoms of dementia in the elderly
    Manju T Beier
    Geriatric Consultant Resources LLC, Ann Arbor, MI, USA
    Am J Health Syst Pharm 64:S9-17; quiz S24-5. 2007
    ..The use of atypical antipsychotics for maximizing clinical efficacy and overall health in patients with neuropsychiatric symptoms of dementia is discussed...
  75. ncbi Efficacy of music therapy in the treatment of behavioral and psychiatric symptoms of dementia
    Alfredo Raglio
    Sospiro Foundation, Sospiro, Cremona, Italy
    Alzheimer Dis Assoc Disord 22:158-62. 2008
    ..Music therapy (MT) has been proposed as valid approach for behavioral and psychologic symptoms (BPSD) of dementia. However, studies demonstrating the effectiveness of this approach are lacking...
  76. ncbi [Neuropsychiatric symptoms of dementia: psychometric aspects of the Dutch Neuropsychiatric Inventory (NPI)]
    M G Kat
    Medisch Centrum Alkmaar
    Tijdschr Gerontol Geriatr 33:150-5. 2002
    ..The NPI Dutch version can be scored objectively and it is a valid rating scale for measuring a wide range of behavioral and psychological symptoms of dementia...
  77. ncbi Behavioral effects of memantine in Alzheimer disease patients receiving donepezil treatment
    Jeffrey L Cummings
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, USA
    Neurology 67:57-63. 2006
    ..To investigate the behavioral effects of memantine in moderate to severe Alzheimer disease (AD)...
  78. ncbi Report on an open-label prospective study of divalproex sodium for the behavioral and psychological symptoms of dementia as monotherapy and in combination with second-generation antipsychotic medication
    Brent Forester
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Am J Geriatr Pharmacother 5:209-17. 2007
    ..Studies of pharmacotherapy for agitation in dementia have primarily been limited to single-drug trials and have not determined if some forms of agitated behaviors are more responsive to treatment than others...
  79. ncbi Mild parkinsonian signs and psycho-behavioral symptoms in subjects with mild cognitive impairment
    Luca Rozzini
    Department of Neurology, University of Brescia, Italy
    Int Psychogeriatr 20:86-95. 2008
    ..We aimed to elucidate further the relationship between MCI and EPS, analyzing the correlation between the severity of EPS and cognitive functions, and the presence of EPS and neuro-psychiatric features...
  80. ncbi Agitation and resistiveness to care are two separate behavioral syndromes of dementia
    Ladislav Volicer
    School of Aging Studies, University of South Florida, Tampa, FL, USA
    J Am Med Dir Assoc 8:527-32. 2007
    ..To distinguish two behavioral syndromes of dementia: Agitation and resistiveness to care...
  81. ncbi Atypical antipsychotics for the treatment of dementia-related behaviors: an update
    Lori A Daiello
    The Warren Alpert Medical School of Brown University, USA
    Med Health R I 90:191-4. 2007
    Atypical antipsychotics will continue to be prescribed for the behavioral symptoms of dementia in the absence of more effective, better tolerated, and safer alternatives...
  82. ncbi Behavioral and psychological symptoms assessed with the BEHAVE-AD-FW are differentially associated with cognitive dysfunction in Alzheimer's disease
    T Ito
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, and The Kawasaki Kokoro Hospital, Japan
    J Clin Neurosci 14:850-5. 2007
    ..using the Behavioral Pathology in Alzheimer's Disease Frequency Weighted Severity Scale (BEHAVE-AD-FW) for behavioral symptoms and psychological symptoms separately, and cognitive function was also assessed using the Cognitive ..
  83. ncbi Behavioural measures in frontotemporal lobar dementia and other dementias: the utility of the frontal behavioural inventory and the neuropsychiatric inventory in a national cohort study
    M Blair
    Department of Cognitive Neurology and Alzheimer s Research Centre, St Joseph s Health Care, University of Western Ontario, London, Canada
    Dement Geriatr Cogn Disord 23:406-15. 2007
    ....
  84. ncbi Efficacy and safety of galantamine in patients with dementia with Lewy bodies: a 24-week open-label study
    Keith Edwards
    Alzheimer s Diagnostic and Treatment Center, Bennington, VT 05201, USA
    Dement Geriatr Cogn Disord 23:401-5. 2007
    ..Dementia with Lewy bodies (DLB) is a common dementia of the elderly. A significant cholinergic deficit has been demonstrated that may be responsive to treatment by cholinesterase inhibitors (ChEIs)...
  85. ncbi Amisulpride versus risperidone treatment for behavioral and psychological symptoms in patients with dementia of the Alzheimer type: a randomized, open, prospective study
    Hyun Kook Lim
    Department of Psychiatry, Kangnam St Mary s Hospital, Seoul, South Korea
    Neuropsychobiology 54:247-51. 2006
    ..This study showed that either amisulpride or risperidone would be effective and tolerable for treating patients with DAT. Adequately powered studies with a head-to-head comparison design will be mandatory to draw any definite conclusion...
  86. ncbi Prevalence and correlates of disruptive behavior in patients in Norwegian nursing homes
    I Testad
    Stavanger University Hospital, Psychiatric Clinic, Stavanger, Norway
    Int J Geriatr Psychiatry 22:916-21. 2007
    ..of Dementia (BPSD) increase with increasing dementia severity, and institutionalization of an individual with dementia is often caused by behavioral symptoms, relatively few studies have explored the prevalence of BPSD in nursing homes.
  87. ncbi Caregiver burden associated with behavioral and psychological symptoms of dementia in elderly people in the local community
    Naomi Matsumoto
    Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Ehime, Japan
    Dement Geriatr Cogn Disord 23:219-24. 2007
    ..Despite many studies about the association between caregiver burden and behavioral and psychological symptoms of dementia (BPSD), there have been no population-based studies to evaluate caregiver burden associated with each BPSD...
  88. ncbi When behavioral assessment detects frontotemporal dementia and cognitive testing does not: data from the Frontal Behavioral Inventory
    Graziella Milan
    Centro Geriatrico Sovradistrettuale Frullone, ASL Napoli 1, Naples, Italy
    Int J Geriatr Psychiatry 22:266-7. 2007
  89. ncbi Utility of behavioral versus cognitive measures in differentiating between subtypes of frontotemporal lobar degeneration and Alzheimer's disease
    Jennifer Heidler-Gary
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Dement Geriatr Cogn Disord 23:184-93. 2007
    ..These tests may be useful for efficient clinical diagnosis, although progressive nonfluent aphasia and semantic dementia are likely to be best distinguished by language tests not included in standard neuropsychological test batteries...
  90. ncbi Impact of behavioural problems on spousal caregivers: a comparison between Alzheimer's disease and frontotemporal dementia
    Marjolein E de Vugt
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    Dement Geriatr Cogn Disord 22:35-41. 2006
    ..The aim of this study was to compare caregivers' distress related to behavioural symptoms of AD and FTD...
  91. ncbi Validity and reliability of the newly translated Hellenic Neuropsychiatric Inventory (H-NPI) applied to Greek outpatients with Alzheimer's disease: a study of disturbing behaviors among referrals to a memory clinic
    Antonis M Politis
    The Johns Hopkins University, Baltimore, MD 21287, USA
    Int J Geriatr Psychiatry 19:203-8. 2004
    ..No rating scales of the neuropsychiatric symptoms of patients with dementia and Alzheimer's disease (AD) have previously been developed or translated...
  92. ncbi [Behavioural disorders in Alzheimer's disease. Data from a populational study]
    M De Toledo
    Servicio de Neurologia, Hospital Universitario de Guadalajara, Guadalajara
    Rev Neurol 38:901-5. 2004
    ....
  93. ncbi Reduction of behavioral disturbances and caregiver distress by galantamine in patients with Alzheimer's disease
    Jeffrey L Cummings
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles 90095 1769, USA
    Am J Psychiatry 161:532-8. 2004
    ....
  94. ncbi Knight's move thinking? Mild cognitive impairment in a chess player
    H A Archer
    The Dementia Research Centre, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurocase 11:26-31. 2005
    ....
  95. ncbi A randomized, placebo-controlled study of the efficacy and safety of sertraline in the treatment of the behavioral manifestations of Alzheimer's disease in outpatients treated with donepezil
    Sanford I Finkel
    Department of Psychiatry, University of Chicago Medical School, and the Leonard Schanfield Research Institute at Council for Jewish Elderly, Chicago, IL 60091, USA
    Int J Geriatr Psychiatry 19:9-18. 2004
    ..To examine the safety and efficacy of sertraline augmentation therapy in the treatment of behavioral manifestations of Alzheimer's disease (AD) in outpatients treated with donepezil...
  96. ncbi The use of olanzapine in the treatment of negative symptoms in Alzheimer's disease
    Eric D Rankin
    Department of Behavioral Medicine and Psychiatry, West Virginia University, 930 Chestnut Ridge Rd, Morgantown, WV 26505 2854, USA
    J Neuropsychiatry Clin Neurosci 17:423-4. 2005
    ..Subjects were AD patients age 50 and older who exhibited untreated neuropsychiatric symptoms. Findings suggest that a therapeutic profile for olanzapine may be appropriate for AD patients experiencing neuropsychiatric problems...
  97. ncbi Psychiatric and behavioral symptoms in Alzheimer's disease and other dementias: etiology and management
    Dag Aarsland
    Centre for Clinical Neuroscience Research, Stavanger University Hospital, PO Box 1163, 4095 Stavanger, Norway
    Curr Neurol Neurosci Rep 5:345-54. 2005
    Psychiatric and behavioral symptoms are common in all types of dementia and have important consequences for patients, caregivers, and society. This paper reviews recent studies of the etiology and management of these symptoms...
  98. ncbi "Frontal variant Alzheimer's disease": a reappraisal
    Andrew J Larner
    Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    Clin Neurol Neurosurg 108:705-8. 2006
    ..The proposed usage would also emphasise differential diagnosis...
  99. ncbi Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease
    Harish C Kavirajan
    Neurology 65:338-9; author reply 338-9. 2005
  100. ncbi [Introduction: how to examine a patient with cognitive disorders]
    Katsuhiko Takeda
    Department of Neurology, Japanese Red Cross Medical Center, 4 1 22 Hiroo, Shibuya ku, Tokyo 150 8935, Japan
    No To Shinkei 57:357-63. 2005
  101. ncbi Alzheimer's disease and frontal variant of frontotemporal dementia-- a very brief battery for cognitive and behavioural distinction
    Roberta Perri
    Fondazione IRCCS Santa Lucia, Via Ardeatina, 306, 00179 Roma, Italy
    J Neurol 252:1238-44. 2005
    ..The present results emphasise the importance of rating both cognitive and behavioural clinical features of the two syndromes as objectively as possible to improve differential diagnostic accuracy...

Research Grants66

  1. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    CHARLES WILLIAM WILKINSON; Fiscal Year: 2012
    ..Hypopituitarism is associated with numerous non-specific symptoms easily mistaken for behavioral symptoms of posttraumatic stress disorder (PTSD) and chronic postconcussive syndrome, including fatigue, anxiety, ..
  2. Adenosine and the Basal Forebrain in the Control of Behavioral State
    Robert E Strecker; Fiscal Year: 2012
    ..alter the behavioral &physiological response to AD drugs? On the first day of CSR, we predict that the behavioral symptoms will correlate with an elevation of BF AD levels, whereas on CSR days 3-10, changes in A1 &A2a ..
  3. Mechanisms of structural plasticity in stress-related disorders
    Scott J Russo; Fiscal Year: 2013
    ..such as major depressive disorder (MDD) and post traumatic stress disorder (PTSD) cause overlapping behavioral symptoms marked by hyperarousal, social avoidance, anxiety, increased startle responses and emotional numbing or ..
  4. Scheduled and Responsive Brain Stimulation for the Treatment of Tourette Syndrome
    Michael S Okun; Fiscal Year: 2010
    ..TS can also include a wide spectrum of behavioral symptoms. One brain area, the centromedian thalamus (CM) has shown the most promise (N>20) as a therapeutic ..
  5. Immunomodulatory Roles of Amyloid-Beta and Amyloid Precursor Protein in CNS Autoi
    JACQUELINE LEIGH GRANT; Fiscal Year: 2012
    ..Furthermore, in a mouse model lacking APP expression, EAE induction resulted in drastic mortality and behavioral symptoms uncharacteristic of classic EAE disease progression...
  6. Regulation of BimEL phosphorylation in the pathogenesis of Huntington's disease
    Jianning Wei; Fiscal Year: 2012
    ..In Aim 3b, we will test if the crossed mice show improvements in behavioral symptoms compared to R6/2 mice using well-established behavioral measurements...
  7. Nicotine and impulsivity in an animal model of ADHD
    Federico Sanabria; Fiscal Year: 2011
    ..Experimental research in psychiatric and non-psychiatric populations has shown that nicotine alleviates behavioral symptoms associated with ADHD...
  8. Basal Ganglia and Higher Cortical Function
    Peter L Strick; Fiscal Year: 2012
    ..activity in BG loops with the cerebral cortex could lead not only to motor disorders, but also to the behavioral symptoms associated with neuropsychiatric disorders like Depression, Obsessive-Compulsive Disorder (OCD) and ..
  9. Stress Regulation of Non-Coding RNAs in Prefrontal Cortex
    James P Herman; Fiscal Year: 2012
    ..The unpredictable stress regimen reliably models physiological and behavioral symptoms of depression, allowing for extrapolation of preclinical findings to putative mechanisms of functional ..
  10. Therapeutic Effects of Cataract Removal in Alzheimer's Disease
    GROVER CLEVELAND GILMORE; Fiscal Year: 2013
    ..The latter will help to assure protocol adherence by the AD participants and will provide information about behavioral symptoms, activities of daily living, and amount of resources used...
  11. Stress-Induced Depression and Parkinsonian Symptomology
    Kim B Seroogy; Fiscal Year: 2012
    ..if stress-induced depression either following, preceding, or flanking neurotoxin lesioning exacerbates behavioral symptoms and dopaminergic neuronal degeneration and related behavioral and neurochemical sequelae in the injured ..
  12. Prodrugs of NAAG Peptidase Inhibitors for the Treatment of Schizophrenia
    Jia Zhou; Fiscal Year: 2009
    ..Group II mGluR activation inhibits the release of glutamate and reduces the schizophrenia-like behavioral symptoms elicited by phencyclidine (PCP)...
  13. Transcriptional regulatory cascade of midbrain dopamine neuron development by Pit
    Kwang Soo Kim; Fiscal Year: 2012
    ..DA-specific gene delivery method, we will test if gene therapy approach of these key factors may ameliorate behavioral symptoms in PD animal model(s)...
  14. A Genetic Study of Schizophrenia Endophenotypes in Sub-Saharan Africans
    Ikwunga Wonodi; Fiscal Year: 2012
    ..linking susceptibility genes (of small effect) to translated protein or function compared to analysis of behavioral symptoms only [5]. One highly reproducible SZ biomarker (i.e...
  15. Biomarkers of Autism at 12 months: From Brain Overgrowth to Genes
    Eric Courchesne; Fiscal Year: 2013
    ..relevant and practical method is to study individuals referred by physicians because they display behavioral symptoms indicating risk for an ASD...
  16. Nonpharmacologic Management of Challenging Behaviors in Veterans with Dementia
    William C Mann; Fiscal Year: 2013
    ..but these are at best modestly effective, carry serious risks including mortality, and do not address behavioral symptoms families themselves consider most distressful or that prompt nursing home placement...
  17. An Innovative Caregiver Tool to Assess and Manage Behavioral Symptoms of Dementia
    Helen C Kales; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A hallmark characteristic of dementia of all types is disruptive behavioral symptoms. More so than memory and cognitive impairments, these behaviors are among the most complex, stressful and costly ..
  18. Proactive Primary Dementia Care
    Richard H Fortinsky; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Dementia is a public health problem of rapidly growing proportions. Cognitive and behavioral symptoms characteristic of dementia are often extremely stressful to patients and their families...
  19. Latent variable analysis in cognitive aging and executive function
    ROCHELLE ELAINE TRACTENBERG; Fiscal Year: 2010
    ..the hypothesis that EF contributes significant explanatory power for variance in cognitive, functional and behavioral symptoms and will suggest whether this is true for both normal elderly and persons with AD...
  20. Executive Function/Metacognitive Training for At-Risk Preschoolers
    Leanne Tamm; Fiscal Year: 2013
    ..on objective measures of EF (16) and moderate to large effect size reductions in ratings of inattention and behavioral symptoms by parents, clinicians, and teachers...
  21. Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury
    RICARDO ESTEBAN JORGE; Fiscal Year: 2012
    ..Early preventive treatment with sertraline would reduce sub-threshold mood and behavioral symptoms, prevent the occurrence of structural and functional brain changes associated with the onset of mood ..
  22. Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms
    Michael R Irwin; Fiscal Year: 2010
    ..After completion of successful therapy, many behavioral symptoms persist with over 20% of breast cancer survivors reporting chronic insomnia of greater than 6 months ..
  23. Gains and Losses: Reward Processing in Pediatric Major Depressive Disorder
    KATHERINE ROSE LUKING; Fiscal Year: 2013
    ..Success in this work would provide important information about the continuity of the neurobiological and behavioral symptoms of MDD over the course of development...
  24. Refinement and Validation of a Portable, Salivary Biosensor of Psychosocial Stres
    Vivek Shetty; Fiscal Year: 2010
    ..g., distress, anxiety, depression) and behavioral symptoms (e.g., increased substance use) following injury...
  25. Progression of Dementia: A Population Study
    JOANN T contact TSCHANZ; Fiscal Year: 2010
    ..with slower progression; 4) Examine the effects of modifiable factors on the emergence and persistence of behavioral symptoms and symptom clusters; 5) Examine putative mechanisms underlying the relationship between the care ..
  26. Perceptual Factors Affecting Social Attention in Autism Spectrum Disorders
    Suzanne Macari; Fiscal Year: 2010
    ..on visuo-perceptual abnormalities in the early stages of ASD, perhaps even prior to the manifestation of behavioral symptoms in this area, and thus advance our understanding of the processes and mechanisms underlying behavioral ..
  27. Social Isolation and Sleep Disturance in Aging: Inflammatory Mechanisms
    Michael R Irwin; Fiscal Year: 2013
    ..in socially isolated older adults;and 3) to examine the contribution of sleep loss and recovery sleep to behavioral symptoms and cellular and genomic markers of inflammation in socially isolated older adults...
  28. Investigating the Gut Microbiome for Novel Therapies and Diagnostics for Autism
    Paul H Patterson; Fiscal Year: 2013
    ..To examine the hypothesis that GI pathology is associated with, and contributes to behavioral symptoms, we employ a mouse model of an ASD risk factor, maternal immune activation (MIA)...
  29. Autism Spectrum Disorder: Birth Cohort 1976-2000, Epidemiology and Adult Status
    Slavica K Katusic; Fiscal Year: 2013
    ..involves an experienced multi-disciplinary research team, confirmation of the availability of documented behavioral symptoms of ASD from 1976 forward, with development of a detailed dictionary of descriptive phrases abstracted from ..
  30. Cannabimimetic Treatment of Obstructive Sleep Apnea: A Proof of Concept Trial
    Phyllis C Zee; Fiscal Year: 2013
    ..obstructive sleep apnea (OSA), represent an important health problem, conferring substantial cognitive/behavioral symptoms and increased risk of motor vehicle accident, hypertension, myocardial infarction, stroke, diabetes and ..
  31. Cortical contributions to basal ganglia disorders
    PETER STRICK; Fiscal Year: 2006
    ..The overall goal of the experiments in this application is to link the specific motor and behavioral symptoms associated with basal ganglia dysfunction to the cortical areas that are responsible for their expression...
  32. Comparative Safety of Atypical Antipsychotics in High-Risk US Children with ADHD
    David M Rubin; Fiscal Year: 2012
    ..3-8 The majority of SGA use today is non-FDA-approved or 'off-label'use to treat aggressive or behavioral symptoms. SGAs are most frequently given to children with Attention Deficit Hyperactivity Disorder (ADHD) and to ..
  33. Amygdala-Prefrontal Interactions When Interpreting Ambiguous Facial Expressions
    Justin Kim; Fiscal Year: 2010
    ..groups, allowing the assessment of the amygdala-prefrontal circuitry and its relationship to specific behavioral symptoms, as well as providing a quantifiable index of the functional changes in this circuitry that could be ..
  34. Phase III Study of Donepezil in the Irradiated Brain
    Stephen R Rapp; Fiscal Year: 2010
    ..like donepezil (Aricept) has proven effective in improving neurocognitive functioning and behavioral symptoms in patients with Alzheimer's disease...
  35. Alzheimer's Disease Cooperative Study
    Paul S Aisen; Fiscal Year: 2013
    ..Aim 2: Test an intervention to ameliorate behavioral symptoms. We will extend promising early results supporting an adrenergic approach amelioration of behavioral ..
  36. Engaging Immigrants in Preventive Parenting Interventions
    JOYCE RIVERA JAVIER; Fiscal Year: 2013
    ..an evidence-based preventive parenting program demonstrated to improve parenting skills and diminish child behavioral symptoms. The central hypothesis, formulated based on the Health Belief Model and Theory of Planned Behavior is that ..
  37. Genetic Imaging of Working Memory and Interference Control in ADHD
    Larry J Seidman; Fiscal Year: 2012
    ..of working memory and interference control networks, neurocognitive measures of these functions and behavioral symptoms of ADHD...
  38. Solid-state patch clamp platform to diagnose autism and screen for effective drug
    Craig C Garner; Fiscal Year: 2013
    ..Currently, the diagnosis for most forms of ASD is based on a triad of behavioral symptoms, including social impairments, communication difficulties, and repetitive or stereotyped behaviors, with no ..
  39. Method for In-Vivo Assessment of Neuronal Dysfunction
    Miguel A L Nicolelis; Fiscal Year: 2010
    ..alterations in neuronal circuits may occur before neuronal degeneration and may underlie many of the behavioral symptoms associated with neurodegenerative disorders and may be reversible...
  40. Pharmacogenomics in Autism Treatment
    ROBERT LEE HENDREN; Fiscal Year: 2009
    ..is that the efficacy, dose and occurrence of side effects of risperidone for the treatment of serious behavioral symptoms in children with autism will be reflected in specific gene expression/RNA profiles in the blood prior to ..
  41. Pro-Inflammatory cytokines & neurobehavioral symptoms in breast cancer patients
    Sunita K Patel; Fiscal Year: 2010
    ..Abstract Survivors of breast cancer report debilitating behavioral symptoms, such as fatigue and neurocognitive dysfunction, which are evident in some individuals even at pre-..
  42. Reversible conditional models for Huntington's disease
    Scott O Zeitlin; Fiscal Year: 2012
    ..compensatory mechanisms acting during development can delay the onset of neurodegeneration and motor/behavioral symptoms. Our overall objective is to use novel repressible/inducible knockin mouse models for HD to explore the ..
  43. Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar Disorder
    David Miklowitz; Fiscal Year: 2009
    ..We hope to show that (a) early, brief intervention with FFT will decrease mood and behavioral symptoms, improve social and academic functioning, improve family interactions, and provide the at-risk child with ..
  44. Indiana PROSPECT
    JOSEPH MARCUS OVERHAGE; Fiscal Year: 2010
    ..The CER study will evaluate of medication treatment for behavioral symptoms of Alzheimer's disease. Alzheimer's disease has been identified as a first quartile CER priority...
  45. MENTAL ILLNESS IN THE ELDERLY--DIAGNOSTIC TESTING
    Andrew Leuchter; Fiscal Year: 1999
    ..our existing cohort of DAT, MID, and CON subjects, focusing on the evolution of functional disability and behavioral symptoms in relation to QEEG variables, and upon autopsy validation of clinical and QEEG- based diagnoses...
  46. A Pediatrics-Based Intervention for Young Children at Risk for ADHD or ODD
    Ellen Perrin; Fiscal Year: 2010
    ..primary care pediatric office, a parent training program designed to improve parenting skills and diminish behavioral symptoms in very young children at risk for diagnoses of Attention Deficit/Hyperactivity Disorder (ADHD) and ..
  47. HUMAN GENOME EDUCATION MODEL (HUGEM) PROJECT II
    E Lapham; Fiscal Year: 2001
    ..first to: 1) suspect that their clients have a genetic disorder; 2) give a label to the developmental or behavioral symptoms; 3) recommend further evaluations including genetic testing 4) interpret and discuss results of testing and ..
  48. Function and Behavior Focused Care for Nursing Home Residents with Dementia
    Elizabeth M Galik; Fiscal Year: 2013
    ..model and is designed to change nursing staff behavior by motivating and teaching them skills to decrease behavioral symptoms and optimize function and physical activity among nursing home residents with dementia...
  49. Infants at Risk of Autism: A Longitudinal Study
    Sally Ozonoff; Fiscal Year: 2013
    ..Based on our previous findings of few differences in behavioral symptoms at 6 and 12 months of age, experimental measures used with the new sample will focus on underlying ..
  50. Gene-Environment Interplay and Development of Psychiatric Symptoms in Children
    Jenae M Neiderhiser; Fiscal Year: 2013
    ..the rich existing data, the proposed data will allow us to better characterize early emerging emotional and behavioral symptoms in children that have been shown to predict later psychiatric problems...
  51. Ultra-Resolution Imaging of Brain Circuitry and its Development in Mental Health
    Chunlei Liu; Fiscal Year: 2013
    ..imaging-genetics study would help us to better understand the genetic and developmental components of the disease, to detect circuit abnormalities before behavioral symptoms, and to eventually guide treatment strategies.
  52. HALOPERIDOL AND ATTENTIONAL LEARNING IN AUTISTIC CHILDRE
    Magda Campbell; Fiscal Year: 1991
    ..1) To critically assess the efficacy and safety of naltrexone in the treatment of autism: its effects on behavioral symptoms and on learning...
  53. Procognitive and Antipsychotic Actions of JWS-USC-75-IX
    Alvin Terry; Fiscal Year: 2009
    ..are limited by modest efficacy, adverse side effects, and the fact that the very problematic non-cognitive behavioral symptoms (e.g., agitation) of the illness are left untreated...
  54. Antipsychotics and Mortality in Older Patients
    HELEN KALES; Fiscal Year: 2009
    ..mortality risk for elderly outpatients with dementia than other psychotropic medications often used for behavioral symptoms. These increased risks may persist for as long as 12 months following new antipsychotic starts...
  55. BEHAVIOR & HYPERTHYROIDISM: A BETA-ADRENERGIC MECHANISM?
    Paula Trzepacz; Fiscal Year: 1991
    ..We hypothesize that the behavioral symptoms of Graves' disease are in part mediated by thyroid hormone-induced changes of CNS beta adrenergic receptors...
  56. Role of CREB function in the BNST in fear and anxiety-like behaviors
    Edward Meloni; Fiscal Year: 2007
    ..unreadable] Relevance: The development and manifestation of behavioral symptoms of some anxiety disorders (e.g...
  57. PROBING DRUG RELATED MENTAL DISORDERS OF AGING
    Ira Katz; Fiscal Year: 2003
    ..Therefore, studies of the cognitive, affective, and behavioral symptoms that result from the administration of centrally-acting medications can provide information about the ..
  58. Neural markers of shared gaze during simulated social interactions in ASD
    JAMES CHARLES MCPARTLAND; Fiscal Year: 2013
    ..developing biologically-baed predictors of treatment response, creating new treatment approaches, defining subgroups of individuals with ASD, and detecting atypical brain development in ASD before behavioral symptoms become evident.
  59. Method for In-Vivo Assessment of Neuronal Dysfunction
    Miguel Nicolelis; Fiscal Year: 2007
    ..alterations in neuronal circuits may occur before neuronal degeneration and may underlie many of the behavioral symptoms associated with neurodegenerative disorders and may be reversible...
  60. Efficacy of Amantadine Hydochloride after Pediatric TBI
    SUE BEERS; Fiscal Year: 2002
    ..Treatment with amantadine hydrochloride (AMH), a dopamine agonist, has been shown to improve behavioral symptoms and executive function in adults after brain injury...
  61. DNA EXPANSION IN SCHIZOPHRENIA
    Cynthia McMurray; Fiscal Year: 2000
    ..disorder characterized by psychotic symptoms such as delusions and hallucinations and/or debilitating behavioral symptoms. Schizophrenia afflicts approximately one percent of the population worldwide, making this one of the most ..
  62. CORTICOSTEROID RECEPTORS AND HPA AXIS ADAPTATION
    Robert Spencer; Fiscal Year: 1999
    ..The HPA axis of many depressed individuals is hyperactive, and many of the physical and behavioral symptoms associated with depression resemble those present during an acute stress state...
  63. Cocaine-induced planarian behavior and its modulation by sesquiterpene lactones
    ONE PAGAN; Fiscal Year: 2009
    ..Planarians can exhibit behavioral symptoms consistent with cocaine "withdrawal" and show morphological changes in their nervous system directly ..
  64. Anxiety Among Older Adults with Dementia in ALFs
    Marianne Smith; Fiscal Year: 2006
    ..create distress and discomfort and are associated comorbid depression, greater functional impairment, behavioral symptoms, reduced quality of life, and increased mortality...
  65. PET IMAGING AND SEROTONIN LIGANDS IN EATING DISORDERS
    Walter Kaye; Fiscal Year: 2005
    ..that a malfunction of pre-synaptic raphe autoreceptors could contribute to increased 5-HT activity and behavioral symptoms. Thus, 1A binding may not change with state of the illness...
  66. Reminiscence During Bathing Persons With AD At Home
    Ellen Mahoney; Fiscal Year: 2004
    ..Encountering these behaviors is distressing for caregivers as well. Most studies of interventions for behavioral symptoms of AD have been done in nursing homes, but most care takes place in the home...