patient acceptance of health care

Summary

Summary: The seeking and acceptance by patients of health service.

Top Publications

  1. ncbi Expanding access to voluntary HIV counselling and testing in sub-Saharan Africa: alternative approaches for improving uptake, 2001-2007
    Joseph K B Matovu
    Rakai Health Sciences Program Uganda Virus Research Institute, Entebbe, Uganda
    Trop Med Int Health 12:1315-22. 2007
  2. ncbi Revisiting the behavioral model and access to medical care: does it matter?
    R M Andersen
    Department of Health Services, School of Public Health, UCLA 90024 1772, USA
    J Health Soc Behav 36:1-10. 1995
  3. pmc A systematic review of delay in the diagnosis and treatment of tuberculosis
    Dag Gundersen Storla
    Department of International Health, Institute of General Practice and Community Medicine, University of Oslo, PO Box 1130 Blindern, N 0318 Oslo, Norway
    BMC Public Health 8:15. 2008
  4. pmc Still too far to walk: literature review of the determinants of delivery service use
    Sabine Gabrysch
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    BMC Pregnancy Childbirth 9:34. 2009
  5. ncbi Patients' help-seeking experiences and delay in cancer presentation: a qualitative synthesis
    Lucy K Smith
    Department of Health Sciences, University of Leicester, Leicester LE1 6TP, UK
    Lancet 366:825-31. 2005
  6. pmc Decreased motivation in the use of insecticide-treated nets in a malaria endemic area in Burkina Faso
    Léa Paré Toé
    Institut de Recherche en Science de Santé Centre Muraz, BP 390, Bobo Dioulasso, Burkina Faso
    Malar J 8:175. 2009
  7. pmc Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care
    G Peat
    Primary Care Sciences Research Centre, Keele University, UK
    Ann Rheum Dis 60:91-7. 2001
  8. ncbi Factors affecting home delivery in rural Tanzania
    Mwifadhi Mrisho
    Ifakara Health Research and Development Centre, Dar es Salaam, Tanzania
    Trop Med Int Health 12:862-72. 2007
  9. ncbi Low male partner participation in antenatal HIV counselling and testing in northern Tanzania: implications for preventive programs
    S E Msuya
    Department of International Health, University of Oslo, Norway
    AIDS Care 20:700-9. 2008
  10. pmc Utilization of maternal health services among young women in Kenya: insights from the Kenya Demographic and Health Survey, 2003
    Rhoune Ochako
    African Population and Health Research Center APHRC, P, O, Box 10787, 00100 Nairobi, Kenya
    BMC Pregnancy Childbirth 11:1. 2011

Detail Information

Publications373 found, 100 shown here

  1. ncbi Expanding access to voluntary HIV counselling and testing in sub-Saharan Africa: alternative approaches for improving uptake, 2001-2007
    Joseph K B Matovu
    Rakai Health Sciences Program Uganda Virus Research Institute, Entebbe, Uganda
    Trop Med Int Health 12:1315-22. 2007
    ..We recommend that these alternative models be implemented in more settings and on a much larger scale in sub-Saharan Africa, where VCT uptake rates remain low...
  2. ncbi Revisiting the behavioral model and access to medical care: does it matter?
    R M Andersen
    Department of Health Services, School of Public Health, UCLA 90024 1772, USA
    J Health Soc Behav 36:1-10. 1995
    ..The Behavioral Model of Health Services Use was initially developed over 25 years ago. In the interim it has been subject to considerable application, reprobation, and alteration. I review its development and assess its continued relevance...
  3. pmc A systematic review of delay in the diagnosis and treatment of tuberculosis
    Dag Gundersen Storla
    Department of International Health, Institute of General Practice and Community Medicine, University of Oslo, PO Box 1130 Blindern, N 0318 Oslo, Norway
    BMC Public Health 8:15. 2008
    ..Delay in diagnosis is significant to both disease prognosis at the individual level and transmission within the community. Most transmissions occur between the onset of cough and initiation of treatment...
  4. pmc Still too far to walk: literature review of the determinants of delivery service use
    Sabine Gabrysch
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    BMC Pregnancy Childbirth 9:34. 2009
    ....
  5. ncbi Patients' help-seeking experiences and delay in cancer presentation: a qualitative synthesis
    Lucy K Smith
    Department of Health Sciences, University of Leicester, Leicester LE1 6TP, UK
    Lancet 366:825-31. 2005
    ..We undertook a qualitative synthesis of international research evidence to provide insight into patients' experiences of recognising symptoms of cancer and seeking help...
  6. pmc Decreased motivation in the use of insecticide-treated nets in a malaria endemic area in Burkina Faso
    Léa Paré Toé
    Institut de Recherche en Science de Santé Centre Muraz, BP 390, Bobo Dioulasso, Burkina Faso
    Malar J 8:175. 2009
    ..The reasons were a combination of the community representation of malaria, the perception of the effectiveness and usefulness of ITNs and also the manner in which households are organized by day and by night...
  7. pmc Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care
    G Peat
    Primary Care Sciences Research Centre, Keele University, UK
    Ann Rheum Dis 60:91-7. 2001
    ..Osteoarthritis is the single most common cause of disability in older adults, and most patients with the condition will be managed in the community and primary care...
  8. ncbi Factors affecting home delivery in rural Tanzania
    Mwifadhi Mrisho
    Ifakara Health Research and Development Centre, Dar es Salaam, Tanzania
    Trop Med Int Health 12:862-72. 2007
    ..This study combines an understanding of gender issues relating to health and help-seeking behaviour with epidemiological knowledge concerning place of delivery...
  9. ncbi Low male partner participation in antenatal HIV counselling and testing in northern Tanzania: implications for preventive programs
    S E Msuya
    Department of International Health, University of Oslo, Norway
    AIDS Care 20:700-9. 2008
    ..Also, promotion of couple VCT outside antenatal settings in male friendly and accessible settings should be given priority...
  10. pmc Utilization of maternal health services among young women in Kenya: insights from the Kenya Demographic and Health Survey, 2003
    Rhoune Ochako
    African Population and Health Research Center APHRC, P, O, Box 10787, 00100 Nairobi, Kenya
    BMC Pregnancy Childbirth 11:1. 2011
    ....
  11. pmc Acceptability of male circumcision for prevention of HIV/AIDS in sub-Saharan Africa: a review
    N Westercamp
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, 1603 W Taylor Street, MC 923, Chicago, IL 60612, USA
    AIDS Behav 11:341-55. 2007
    ..We recommend pilot interventions making safe circumcision services available in conjunction with current HIV prevention strategies and evaluating the safety and acceptability of circumcision...
  12. pmc Project Accept (HPTN 043): a community-based intervention to reduce HIV incidence in populations at risk for HIV in sub-Saharan Africa and Thailand
    Gertrude Khumalo-Sakutukwa
    Center for AIDS Prevention Studies, University of California, San Francisco, 50 Beale Street, Suite 1300, San Francisco, CA 94105, USA
    J Acquir Immune Defic Syndr 49:422-31. 2008
    ..Changing community norms to increase awareness of HIV status and reduce HIV-related stigma has the potential to reduce the incidence of HIV-1 infection in the developing world...
  13. pmc Stigma in the HIV/AIDS epidemic: a review of the literature and recommendations for the way forward
    Anish P Mahajan
    UCLA Program in Global Health, University of California, Los Angeles, California 90024, USA
    AIDS 22:S67-79. 2008
    ..Based on the literature, we conclude by offering a set of recommendations that may represent important next steps in a multifaceted response to stigma in the HIV/AIDS epidemic...
  14. pmc Healthcare-seeking behaviour for common infectious disease-related illnesses in rural Kenya: a community-based house-to-house survey
    Deron C Burton
    Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Health Popul Nutr 29:61-70. 2011
    ..Seeking healthcare at health facilities and hospitals varied by syndrome, severity of illness, and characteristics of the patient...
  15. pmc Healthcare-use for major infectious disease syndromes in an informal settlement in Nairobi, Kenya
    Robert F Breiman
    International Emerging Infections Program, CDC Kenya Medical Research Institute, Nairobi, Kenya
    J Health Popul Nutr 29:123-33. 2011
    ..The findings support community-based rather than facility-based surveillance in this setting to achieve objectives for comprehensive assessment of the burden of disease...
  16. ncbi Low use of rural maternity services in Uganda: impact of women's status, traditional beliefs and limited resources
    Grace Bantebya Kyomuhendo
    Department of Women and Gender Studies, Makerere University, Kampala, Uganda
    Reprod Health Matters 11:16-26. 2003
    ....
  17. ncbi Health seeking behaviour and diagnosis for pulmonary tuberculosis in an HIV-epidemic mountainous area of Thailand
    J Ngamvithayapong
    TB HIV Research Project, The Research Institute of Tuberculosis, Japan Anti TB Association, Chiang Rai, Thailand
    Int J Tuberc Lung Dis 5:1013-20. 2001
    ..Chiang Rai Hospital, Chiang Rai Province, the epicentre of the human immunodeficiency virus (HIV) in Thailand...
  18. pmc Patient delay in cancer studies: a discussion of methods and measures
    Rikke Sand Andersen
    The Research Unit for General Practice, Institute of Public Health, University of Aarhus, Bartholins Alle 2, DK 8000 Aarhus C, Denmark
    BMC Health Serv Res 9:189. 2009
    ..This lack of a validated measure hampers research in patient delay and is counterproductive to efforts directed at securing early diagnosis of cancer...
  19. pmc High ANC coverage and low skilled attendance in a rural Tanzanian district: a case for implementing a birth plan intervention
    Moke Magoma
    Infectious Diseases Epidemiology Unit, Department of Epidemiology and Population, Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Pregnancy Childbirth 10:13. 2010
    ..The perspectives of health care providers and traditional birth attendants on childbirth and the factors determining where women deliver were also investigated...
  20. pmc Access to health care in contexts of livelihood insecurity: a framework for analysis and action
    Brigit Obrist
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    PLoS Med 4:1584-8. 2007
  21. pmc Adoption, non-adoption, and abandonment of a personal electronic health record: case study of HealthSpace
    Trisha Greenhalgh
    Healthcare Innovation and Policy Unit, Centre for Health Sciences, Barts and the London School of Medicine and Dentistry, London E1 2AT, UK
    BMJ 341:c5814. 2010
    ....
  22. ncbi Predictors of HPV vaccine acceptability: a theory-informed, systematic review
    Noel T Brewer
    Department of Health Behavior and Health Education, School of Public Health, University of North Carolina, 306 Rosenau Hall CB 7440, Chapel Hill, NC 27516, USA
    Prev Med 45:107-14. 2007
    ....
  23. pmc Intermittent preventive treatment of malaria during pregnancy: a qualitative study of knowledge, attitudes and practices of district health managers, antenatal care staff and pregnant women in Korogwe District, North-Eastern Tanzania
    Godfrey Mubyazi
    National Institute for Medical Research, Ubwari Research Station, P O Box 81, Muheza, Tanzania
    Malar J 4:31. 2005
    ..This study assesses the knowledge, attitudes and practices of these groups in relation to malaria control with emphasis on IPTp services...
  24. ncbi Men and health help-seeking behaviour: literature review
    Paul M Galdas
    School of Healthcare, University of Leeds, PO Box 214, Leeds LS2 9UT, West Yorkshire, UK
    J Adv Nurs 49:616-23. 2005
    ..This paper reviews the key research literature regarding men's health-related help seeking behaviour...
  25. pmc Acceptability of evidence-based neonatal care practices in rural Uganda - implications for programming
    Peter Waiswa
    Makerere University School of Public Health, Kampala, Uganda
    BMC Pregnancy Childbirth 8:21. 2008
    ..A key concern is whether these internationally recommended practices are acceptable and will be demanded by the target community. We explored the acceptability of these interventions in two rural districts of Uganda...
  26. ncbi How stigma interferes with mental health care
    Patrick Corrigan
    University of Chicago, Chicago, IL, USA
    Am Psychol 59:614-25. 2004
    ..Implications for the development of antistigma programs that might promote care seeking and participation are also reviewed...
  27. ncbi Treatment-seeking behaviour, cost burdens and coping strategies among rural and urban households in Coastal Kenya: an equity analysis
    Jane Chuma
    Kenya Medical Research Institute, Kilifi, Kenya
    Trop Med Int Health 12:673-86. 2007
    ....
  28. pmc Increasing the acceptability of HIV counseling and testing with three C's: convenience, confidentiality and credibility
    Nicole Angotti
    University of Texas at Austin, TX, USA
    Soc Sci Med 68:2263-70. 2009
    ..Our study suggests that attention to these factors in VCT strategies may mitigate the fear of HIV testing, and ultimately increase uptake in rural African settings...
  29. ncbi High acceptability of voluntary counselling and HIV-testing but unacceptable loss to follow up in a prevention of mother-to-child HIV transmission programme in rural Malawi: scaling-up requires a different way of acting
    M Manzi
    Medecins Sans Frontieres Luxembourg, Thyolo District, Luxembourg, Malawi
    Trop Med Int Health 10:1242-50. 2005
    ..Thyolo District Hospital, rural Malawi...
  30. ncbi Opt-out HIV testing during antenatal care: experiences of pregnant women in rural Uganda
    Elin C Larsson
    Division of Global Health IHCAR, Department of Public Health Sciences, Karolinska Institutet, Nobelsv 9, 171 77, Stockholm, Sweden
    Health Policy Plan 27:69-75. 2012
    ..Moreover, to achieve the desired outcomes of the PMTCT programme, monitoring and evaluation should be built into the programme...
  31. ncbi When and how do young people seek professional help for mental health problems?
    Debra J Rickwood
    School of Health Sciences, University of Canberra, Canberra, ACT, Australia
    Med J Aust 187:S35-9. 2007
    ..Increasingly, Internet-based information and interventions are being used to engage young people in the help-seeking process...
  32. ncbi Factors associated with uptake of vaccination against pandemic influenza: a systematic review
    Alison Bish
    Department of Clinical, Educational and Health Psychology, University College London, 1 19 Torrington Place, London WC1E 7HB, UK
    Vaccine 29:6472-84. 2011
    ..A vaccination programme against H1N1 influenza was introduced in many countries from September 2009, but there was low uptake in both the general population and health professionals in many, though not all, countries...
  33. pmc Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: user acceptability
    Lucy A Smith
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
    Malar J 9:18. 2010
    ..This paper reports on a complementary study investigating the acceptability of the different strategies to women enrolled in the trial...
  34. ncbi Comparison of home and clinic-based HIV testing among household members of persons taking antiretroviral therapy in Uganda: results from a randomized trial
    Eric Lugada
    Centers for Disease Control and Prevention Uganda, Global AIDS Program, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Entebbe, Uganda
    J Acquir Immune Defic Syndr 55:245-52. 2010
    ..Due to high rates of undiagnosed and untreated HIV infection in Africa, we compared HIV counseling and testing (VCT) uptake among household members of patients receiving antiretroviral therapy...
  35. pmc Social and cultural factors affecting uptake of interventions for malaria in pregnancy in Africa: a systematic review of the qualitative research
    Christopher Pell
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e22452. 2011
    ..This article provides a comprehensive overview of qualitative research on social and cultural factors relevant to uptake of MiP interventions in sub-Saharan Africa...
  36. ncbi Brief interventions for alcohol problems: a meta-analytic review of controlled investigations in treatment-seeking and non-treatment-seeking populations
    Anne Moyer
    Center for Health Care Evaluation, VA Palo Alto Health Care System and Stanford University Medical Center, Menlo Park, CA, USA
    Addiction 97:279-92. 2002
    ....
  37. pmc Factors associated with use and non-use of mosquito nets owned in Oromia and Amhara regional states, Ethiopia
    Carol A Baume
    AED, 1825 Connecticut Ave NW Washington, DC 20009, USA
    Malar J 8:264. 2009
    ..Many countries across sub-Saharan Africa are rapidly increasing insecticide-treated net (ITN) coverage to combat malaria, but systematic data on the use of those ITNs and the factors affecting this use are scarce...
  38. pmc Improvements in access to malaria treatment in Tanzania following community, retail sector and health facility interventions -- a user perspective
    Sandra Alba
    Dept Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
    Malar J 9:163. 2010
    ..The effect of these interventions on understanding and treatment of malaria was studied in rural Tanzania. The data also enabled an investigation of the determinants of access to treatment...
  39. pmc Perceived barriers and facilitators to mental health help-seeking in young people: a systematic review
    Amelia Gulliver
    Centre for Mental Health Research, The Australian National University, Canberra, Australia
    BMC Psychiatry 10:113. 2010
    ....
  40. ncbi Effect of the Integrated Management of Childhood Illness strategy on childhood mortality and nutrition in a rural area in Bangladesh: a cluster randomised trial
    Shams E Arifeen
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Lancet 374:393-403. 2009
    ..We assessed the effect of IMCI on health and nutrition of children younger than 5 years in Bangladesh...
  41. pmc Low acceptability of A/H1N1 pandemic vaccination in French adult population: did public health policy fuel public dissonance?
    Michael Schwarzinger
    INSERM, U912 Economic and Social Sciences, Health Systems and Societies, Marseille, France
    PLoS ONE 5:e10199. 2010
    ..In July 2009, French public health authorities embarked in a mass vaccination campaign against A/H1N1 2009 pandemic-influenza. We explored the attitudes and behaviors of the general population toward pandemic vaccination...
  42. ncbi Women's barriers to HIV-1 testing and disclosure: challenges for HIV-1 voluntary counselling and testing
    S Maman
    Department of International Health, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    AIDS Care 13:595-603. 2001
    ..The implications of findings for the promotion of HIV-1 VCT programmes, the implementation of partner notification policies and the development of post-test support services are discussed...
  43. pmc Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites
    IkeOluwapo O Ajayi
    Malaria Research Laboratories, Institute of Medical Research and Training, College of Medicine, University of Ibadan, Nigeria
    Malar J 7:6. 2008
    ..The feasibility and acceptability of incorporating ACT in HMM needs to be evaluated...
  44. ncbi The acceptability of male circumcision to reduce HIV infections in Nyanza Province, Kenya
    R C Bailey
    School of Public Health, University of Illinois at Chicago, USA
    AIDS Care 14:27-40. 2002
    ..Further studies are needed in other regions to assess the feasibility of introducing acceptable male circumcision information and services to reduce HIV transmission...
  45. pmc The forgotten half of the equation: randomized controlled trial of a male invitation to attend couple voluntary counselling and testing
    Boshishi K F Mohlala
    Department of Infectious Disease Epidemiology, Imperial College London, UK
    AIDS 25:1535-41. 2011
    ..Increased male participation in antenatal care and uptake of couple voluntary counselling and testing (VCT) for HIV could reduce horizontal and vertical HIV transmission in sub-Saharan Africa...
  46. ncbi Complementary and alternative medicine use in Australia: a national population-based survey
    Charlie C L Xue
    World Health Organization Collaborating Centre for Traditional Medicine, School of Health Sciences, Melbourne, Melbourne, Australia
    J Altern Complement Med 13:643-50. 2007
    ....
  47. pmc Effectiveness of community based Safe Motherhood promoters in improving the utilization of obstetric care. The case of Mtwara Rural District in Tanzania
    Declare Mushi
    Department of Community Health, Tumaini University Kilimanjaro Christian Medical Centre, P O Box, 2240, Moshi, Kilimanjaro, Tanzania
    BMC Pregnancy Childbirth 10:14. 2010
    ....
  48. pmc Home-based voluntary HIV counselling and testing found highly acceptable and to reduce inequalities
    Wilbroad Mutale
    Department of Community Medicine, School of Medicine, University of Zambia, Lusaka, Zambia
    BMC Public Health 10:347. 2010
    ..We investigated the acceptability of home-based delivery of counselling and HIV testing in urban and rural populations in Zambia where VCT has been offered mostly from local clinics...
  49. pmc Uptake of workplace HIV counselling and testing: a cluster-randomised trial in Zimbabwe
    Elizabeth L Corbett
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Med 3:e238. 2006
    ..HIV counselling and testing is a key component of both HIV care and HIV prevention, but uptake is currently low. We investigated the impact of rapid HIV testing at the workplace on uptake of voluntary counselling and testing (VCT)...
  50. ncbi A randomized trial on acceptability of voluntary HIV counselling and testing
    Knut Fylkesnes
    Centre for International Health, University of Bergen, Bergen, Norway
    Trop Med Int Health 9:566-72. 2004
    ..To examine factors affecting readiness for and acceptability of voluntary HIV counselling and testing (VCT)...
  51. ncbi Access to health: women's status and utilization of maternal health services in Nepal
    Sharad Kumar Sharma
    Institute for Population and Social Research, Mahidol University, Thailand
    J Biosoc Sci 39:671-92. 2007
    ..Socioeconomic and demographic variables such as household economic status, number of living children and place of residence showed stronger association with use of maternal health services then did intervention programmes...
  52. ncbi Feasibility, acceptability and cost of home-based HIV testing in rural Kenya
    Joel Negin
    School of Public Health, University of Sydney, Sydney, Australia
    Trop Med Int Health 14:849-55. 2009
    ..To demonstrate the feasibility, acceptability and cost of home-based HIV testing and to examine the applicability of the model to high HIV prevalence settings...
  53. ncbi Health seeking behaviour and health service utilization in Pakistan: challenging the policy makers
    Babar T Shaikh
    Department of Community Health Sciences, Aga Khan University Karachi, Pakistan
    J Public Health (Oxf) 27:49-54. 2005
    ..Also a more concerted effort is required for designing behavioural health promotion campaigns through inter-sectoral collaboration focusing more on disadvantaged segments of the population...
  54. ncbi Reasons for loss to follow-up among mothers registered in a prevention-of-mother-to-child transmission program in rural Malawi
    L D Bwirire
    Medecins Sans Frontieres, Thyolo District, Malawi
    Trans R Soc Trop Med Hyg 102:1195-200. 2008
    ..Mothers attending antenatal services need to be better informed and supported, at both community and health-provider level...
  55. pmc Effect of home-based HIV counselling and testing on stigma and risky sexual behaviours: serial cross-sectional studies in Uganda
    Fred Nuwaha
    School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda
    J Int AIDS Soc 15:17423. 2012
    ....
  56. ncbi Effect of cardiac rehabilitation referral strategies on utilization rates: a prospective, controlled study
    Sherry L Grace
    School of Kinesiology and Health Sciences, Faculty of Health, York University, 368 Bethune, 4700 Keele St, Toronto, ON M3J 1P3, Canada
    Arch Intern Med 171:235-41. 2011
    ....
  57. pmc Demographic, social cognitive and social ecological predictors of intention and participation in screening for colorectal cancer
    Tess A Gregory
    School of Psychology, University of Adelaide, Adelaide 5000, Australia
    BMC Public Health 11:38. 2011
    ..The aim of this study was to compare the social cognitive and social ecological predictors of intention to screen with predictors of participation...
  58. pmc Trust in physicians and medical institutions: what is it, can it be measured, and does it matter?
    M A Hall
    Wake Forest University School of Medicine, Department of Public Health Sciences, Medical Center Blvd, Winston Salem, NC 27157 1063, USA
    Milbank Q 79:613-39, v. 2001
    ..This conceptual and empirical understanding has significance for ethics, law, and public policy...
  59. ncbi Willingness to use HIV pre-exposure prophylaxis and the likelihood of decreased condom use are both associated with unprotected anal intercourse and the perceived likelihood of becoming HIV positive among Australian gay and bisexual men
    Martin Holt
    National Centre in HIV Social Research, The University of New South Wales, Sydney NSW 2052, Australia
    Sex Transm Infect 88:258-63. 2012
    ..To investigate willingness to use HIV pre-exposure prophylaxis (PrEP) and the likelihood of decreased condom use among Australian gay and bisexual men...
  60. pmc Male perspectives on incorporating men into antenatal HIV counseling and testing
    David A Katz
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    PLoS ONE 4:e7602. 2009
    ..We aimed to identify methods for increasing male involvement in antenatal VCT and determine male correlates of accepting couple counseling in these settings...
  61. pmc Feasibility and acceptability of home-based management of malaria strategy adapted to Sudan's conditions using artemisinin-based combination therapy and rapid diagnostic test
    Khalid A Elmardi
    National Malaria Control Programme, Federal Ministry of Health, Khartoum, Sudan
    Malar J 8:39. 2009
    ..This research aimed to assess the feasibility and acceptability of home-based management of malaria (HMM) strategy using artemisinin-based combination therapy (ACT) for treatment and rapid diagnostic test (RDT) for diagnosis...
  62. pmc Universal testing and treatment as an HIV prevention strategy: research questions and methods
    Richard Hayes
    MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Curr HIV Res 9:429-45. 2011
    ..If these studies produce promising results, there would be a strong case for a cluster-randomised trial to measure the impact of a UTT intervention on HIV incidence, and we consider the main design features of such a trial...
  63. pmc Modelling the effectiveness of chlamydia screening in England
    K M E Turner
    Health Protection Agency, Centre for Infections, 61 Colindale Ave, Colindale, London NW9 5EQ, UK
    Sex Transm Infect 82:496-502. 2006
    ..Mathematical models can incorporate these non-linear effects and estimate the likely impact of different screening programmes and identify areas where more data are needed...
  64. pmc Utilization of public or private health care providers by febrile children after user fee removal in Uganda
    Elizeus Rutebemberwa
    Department of Health Policy Planning and Management, Makerere University School of Public Health, PO Box 7072, Kampala, Uganda
    Malar J 8:45. 2009
    ..The study aimed to assess determinants for use of government facilities or drug shops/private clinics for febrile illnesses in children under five...
  65. pmc Uptake of home-based voluntary HIV testing in sub-Saharan Africa: a systematic review and meta-analysis
    Kalpana Sabapathy
    London School of Hygiene and Tropical Medicine, London, UK
    PLoS Med 9:e1001351. 2012
    ..Improving access to HIV testing is a key priority in scaling up HIV treatment and prevention services. Home-based voluntary counselling and testing (HBT) as an approach to delivering wide-scale HIV testing is explored here...
  66. pmc Exploring provider and community responses to the new malaria diagnostic and treatment regime in Solomon Islands
    Rushika S Wijesinghe
    The University of Queensland, School of Population Health, Pacific Malaria Initiative Support Centre, Australian Centre for International and Tropical Health, Brisbane, Australia
    Malar J 10:3. 2011
    ....
  67. pmc Why do I need it? I am not at risk! Public perceptions towards the pandemic (H1N1) 2009 vaccine
    Holly Seale
    School of Public Health and Community Medicine, Faculty of Medicine, The University of New South Wales, Sydney, Australia
    BMC Infect Dis 10:99. 2010
    ..We surveyed a sample of residents from Sydney, Australia to ascertain their risk perception, attitudes towards the pandemic and willingness to accept the pandemic (H1N1) 2009 influenza vaccine...
  68. pmc A qualitative study on the acceptability and preference of three types of long-lasting insecticide-treated bed nets in Solomon Islands: implications for malaria elimination
    Jo An Atkinson
    Pacific Malaria Initiative Support Centre, School of Population Health SPH, University of Queensland, Brisbane, Australia
    Malar J 8:119. 2009
    ..Compliance with these interventions is dependent on their acceptability and on the socio-cultural context of the local population. These factors need to be investigated locally prior to programme implementation...
  69. ncbi Successful introduction of routine opt-out HIV testing in antenatal care in Botswana
    Tracy L Creek
    Global AIDS Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 45:102-7. 2007
    ..Uptake of antenatal HIV testing was low from 1999 through 2003. In 2004, Botswana's President declared that HIV testing should be "routine but not compulsory" in medical settings...
  70. pmc Barriers to prompt and effective malaria treatment among the poorest population in Kenya
    Jane Chuma
    Kenya Medical Research Institute Wellcome Trust Research Programme, P, O Box, 230, Kilifi, Kenya
    Malar J 9:144. 2010
    ..This paper explores access barriers to effective malaria treatment among the poorest population in four malaria endemic districts in Kenya...
  71. pmc Delayed care seeking for fatal pneumonia in children aged under five years in Uganda: a case-series study
    Karin Kallander
    Division of International Health, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    Bull World Health Organ 86:332-8. 2008
    ..To review individual case histories of children who had died of pneumonia in rural Uganda and to investigate why these children did not survive...
  72. ncbi High uptake of home-based, district-wide, HIV counseling and testing in Uganda
    ELIODA TUMWESIGYE
    Integrated Community Based Initiatives, Kabwohe, Uganda
    AIDS Patient Care STDS 24:735-41. 2010
    ..These results demonstrate that home-based HCT was well-accepted, feasible, and effective in identifying HIV-infected individuals who did not know their HIV status in rural Uganda...
  73. ncbi HPV vaccine acceptability in Ghana, West Africa
    Maame Aba Coleman
    Baylor College of Medicine, Department of Obstetrics and Gynecology, Houston, TX 77030, USA
    Vaccine 29:3945-50. 2011
    ..Cervical cancer is a leading cause of cancer-related mortality among women in Ghana. As of this writing no data are available concerning knowledge, attitudes and acceptability of human papillomavirus (HPV) vaccination by women in Ghana...
  74. ncbi Utilization of maternal health care services in Southern India
    K Navaneetham
    Asian MetaCentre for Population and Sustainable Development Analysis, Institute for Asian Research, National University of Singapore, AS7 Shaw Foundation Building, 117570, Singapore
    Soc Sci Med 55:1849-69. 2002
    ..The findings of this study provide insights for planning and implementing appropriate maternal health service delivery programs in order to improve the health and well-being of both mother and child...
  75. pmc Prevalence of irritable bowel syndrome: a community survey
    Sue Wilson
    Department of Primary Care and General Practice, University of Birmingham, Edgbaston
    Br J Gen Pract 54:495-502. 2004
    ..Such patients may choose to re-consult with the advent of new therapies with a resulting impact on health services...
  76. ncbi Acceptability of male circumcision and predictors of circumcision preference among men and women in Nyanza Province, Kenya
    C L Mattson
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, 1603 W Taylor Street, Chicago, IL 60612, USA
    AIDS Care 17:182-94. 2005
    ....
  77. ncbi Uptake of HIV voluntary counselling and testing services in rural Tanzania: implications for effective HIV prevention and equitable access to treatment
    Alison Wringe
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 13:319-27. 2008
    ..To describe the associations between socio-demographic, behavioural and clinical characteristics and the use of HIV voluntary counselling and testing (VCT) services among residents in a rural ward in Tanzania...
  78. ncbi Health care-seeking practices of pregnant women and the role of the midwife in Cape Town, South Africa
    N Abrahams
    Gender and Health Research Group, Medical Research Council, Tygerberg, Cape Town, South Africa
    J Midwifery Womens Health 46:240-7. 2001
    ..The findings highlight the importance of women's perceptions of quality of care in influencing their health seeking practices. The study suggests that considerably more attention needs to be given to this aspect of maternity services...
  79. ncbi Using the three delays model to understand why newborn babies die in eastern Uganda
    Peter Waiswa
    Division of Global Health, Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden
    Trop Med Int Health 15:964-72. 2010
    ..A survey was conducted in 16 health facilities to determine capacity for newborn care...
  80. ncbi The 2009-2010 influenza pandemic: effects on pandemic and seasonal vaccine uptake and lessons learned for seasonal vaccination campaigns
    Gregory A Poland
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Vaccine 28:D3-13. 2010
    ..This article explores what has been learned about cross-cultural responses to pandemic influenza, and seeks to apply those lessons to seasonal influenza immunization programs...
  81. pmc Development of an international questionnaire to measure use of complementary and alternative medicine (I-CAM-Q)
    Sara A Quandt
    Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1063, USA
    J Altern Complement Med 15:331-9. 2009
    ....
  82. pmc Barriers to accessing TB diagnosis for rural-to-urban migrants with chronic cough in Chongqing, China: a mixed methods study
    Qian Long
    School of Public Health, Chongqing Medical University, No 1 Yixueyuan Road, Chongqing, PR China
    BMC Health Serv Res 8:202. 2008
    ....
  83. ncbi Voluntary counselling and testing: uptake, impact on sexual behaviour, and HIV incidence in a rural Zimbabwean cohort
    Lorraine Sherr
    Royal Free Hospital, University College London, UK
    AIDS 21:851-60. 2007
    ..To examine the determinants of uptake of voluntary counselling and testing (VCT) services, to assess changes in sexual risk behaviour following VCT, and to compare HIV incidence amongst testers and non-testers...
  84. ncbi Results from the first three rounds of the Scottish demonstration pilot of FOBT screening for colorectal cancer
    R J C Steele
    Department of Surgery, University of Dundee, Dundee, UK
    Gut 58:530-5. 2009
    ..To assess the effects of the first three rounds of a pilot colorectal screening programme based on guaiac faecal occult blood testing (gFOBT) and their implications for a national population-based programme...
  85. ncbi Beyond symptom recognition: care-seeking for ill newborns in rural Ghana
    Alessandra N Bazzano
    London School of Hygiene and Tropical Medicine, University of London, London, UK, and College of Health Sciences, Touro University, Vallejo, CA, USA
    Trop Med Int Health 13:123-8. 2008
    ..To assess newborn care-seeking practices in a rural area of Ghana where most births take place at home in order to inform potential strategies for reducing newborn mortality...
  86. ncbi Health-seeking patterns among participants of population-based morbidity surveillance in rural western Kenya: implications for calculating disease rates
    Godfrey Bigogo
    Center for Global Health Research, Kenya Medical Research Institute, PO Box 1578 40100, Kisumu, Kenya
    Int J Infect Dis 14:e967-73. 2010
    ..We describe temporal patterns in health care seeking by syndrome as part of population-based morbidity surveillance in rural western Kenya...
  87. ncbi Overcoming barriers to HIV testing: preferences for new strategies among clients of a needle exchange, a sexually transmitted disease clinic, and sex venues for men who have sex with men
    Freya Spielberg
    University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 32:318-27. 2003
    ..To determine strategies to overcome barriers to HIV testing among persons at risk...
  88. pmc Acceptance of and barriers to voluntary HIV counselling and testing among adults in Guizhou province, China
    Wei Ma
    National Center for AIDS STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
    AIDS 21:S129-35. 2007
    ....
  89. ncbi Gender, socioeconomic development and health-seeking behaviour in Bangladesh
    S M Ahmed
    BRAC Research anid Evaluation Division, BRAC Centre, Dhaka, Bangladesh
    Soc Sci Med 51:361-71. 2000
    ..The policy and programmatic implications of between group and gender differences in care seeking are discussed with reference to the literature...
  90. ncbi Use of insecticide treated nets by pregnant women and associated factors in a pre-dominantly rural population in northern Ethiopia
    Mebrahtom Belay
    UNICEF Country Office, Addis Ababa, Ethiopia
    Trop Med Int Health 13:1303-13. 2008
    ..To describe the use of insecticide treated nets (ITNs) among pregnant women and examine factors associated with its access and use...
  91. ncbi Factors that are associated with parental acceptance of human papillomavirus vaccines: a randomized intervention study of written information about HPV
    Amanda F Dempsey
    Robert Wood Johnson Clinical Scholars Program, University of Washington, Seattle, Washington, USA
    Pediatrics 117:1486-93. 2006
    ....
  92. pmc Voluntary HIV counselling and testing among men in rural western Uganda: implications for HIV prevention
    Francis M Bwambale
    Clinical Epidemiology Unit, Makerere University, POBox 7072, Kampala, Uganda
    BMC Public Health 8:263. 2008
    ..We therefore conducted a study to determine the prevalence and factors associated with VCT use among men in Bukonzo West health sub-district, Kasese district...
  93. pmc Scaling up stigma? The effects of antiretroviral roll-out on stigma and HIV testing. Early evidence from rural Tanzania
    M Roura
    Centre for Population Studies, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Sex Transm Infect 85:308-12. 2009
    ..To investigate the interplay between antiretroviral therapy (ART) scale-up, different types of stigma and Voluntary Counselling and Testing (VCT) uptake 2 years after the introduction of free ART in a rural ward of Tanzania...
  94. ncbi A qualitative analysis of South African women's knowledge, attitudes, and beliefs about HPV and cervical cancer prevention, vaccine awareness and acceptance, and maternal-child communication about sexual health
    Shelley A Francis
    The Ohio State University, Columbus, OH 43210, USA
    Vaccine 29:8760-5. 2011
    ..Prevention strategies should also consider the cultural context and the role that grandmothers play in the family unit...
  95. ncbi Patients seeking care from acupuncture practitioners in the UK: a national survey
    Hugh MacPherson
    Foundation for Traditional Chinese Medicine, York, UK
    Complement Ther Med 14:20-30. 2006
    ..Our secondary aim was to compare the profiles of acupuncture patients with those of a patient survey undertaken in 1988...
  96. ncbi Factors influencing the use of maternal healthcare services in Ethiopia
    Yared Mekonnen
    Ethio Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute, PO Box 1242, Addis Ababa, Ethiopia
    J Health Popul Nutr 21:374-82. 2003
    ..However, this cannot detract from the relevance of service-related factors, especially in the rural areas of the country...
  97. ncbi Web-based self-help for problem drinkers: a pragmatic randomized trial
    Heleen Riper
    Trimbos Institute, Utrecht, The Netherlands
    Addiction 103:218-27. 2008
    ..Self-help interventions for adult problem drinkers in the general population have proved effective. The question is whether this also holds for self-help interventions delivered over the internet...
  98. ncbi Pre-travel health advice-seeking behavior among US international travelers departing from Boston Logan International Airport
    Regina C LaRocque
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    J Travel Med 17:387-91. 2010
    ..Despite this, data about sources of health information used by international travelers are limited...
  99. pmc Effect of repeated invitations on uptake of colorectal cancer screening using faecal occult blood testing: analysis of prevalence and incidence screening
    R J C Steele
    Department of Surgery, University of Dundee, UK
    BMJ 341:c5531. 2010
    ..To analyse the effects of prevalence and incidence screening on uptake and detection of cancer in an ongoing, dynamic programme for colorectal screening using faecal occult blood testing...
  100. ncbi Utilization of health facilities and trained birth attendants for childbirth in rural Bangladesh: an empirical study
    Bimal Kanti Paul
    Department of Geography, Kansas State University, Manhattan 66506, USA
    Soc Sci Med 54:1755-65. 2002
    ..We conclude that quick response to delivery complications and improved access to hospitals and TTBAs can reduce the risk of infant and maternal mortality and morbidity in rural Bangladesh...
  101. pmc HPV vaccine acceptability among Kenyan women
    Sylvia Becker-Dreps
    Department of Family Medicine, University of North Carolina at Chapel Hill, USA
    Vaccine 28:4864-7. 2010
    ..Most women (95%, 95% confidence interval [CI]: 92%, 99%), however, were willing to have their daughters vaccinated with a vaccine that would prevent cervical cancer, with preference for an inexpensive vaccine requiring fewer doses...

Research Grants63

  1. BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINS
    Pi Wan Cheng; Fiscal Year: 2010
    ..Current studies could facilitate the development of therapy for mucus hypersecretory diseases through identification of small carbohydrate inhibitors and mucus cell-specific promoter. ..
  2. Folate and S-adenosyimethionine in Methyl Group and One-carbon Metabolism
    Conrad Wagner; Fiscal Year: 2012
    ....
  3. Electron Transfer in Iron and Copper Proteins
    Jay R Winkler; Fiscal Year: 2013
    ..Efforts will focus on oxidative generation of Compounds I and II in cytochromes P450 (Aim 3) and a bacterial enzyme that exhibits NOS-like reactivity (Aim 4). ..
  4. Development of Novel LANCL2-based Anti-diabetic Compounds
    JOSEP BASSAGANYA; Fiscal Year: 2013
    ..3 million estimated to be over $12.5 Billion for prescription medication costs alone annually in the US. ..
  5. Biosynthetic Protein Models of Heme-copper Oxidases and Nitric Oxide Reductases
    Yi Lu; Fiscal Year: 2013
    ..Therefore the work will make important contributions to healthcare, as it will provide a molecular basis for understanding two enzymes important to human health. ..
  6. Complement Activation on Neisseria meningitidis
    Sanjay Ram; Fiscal Year: 2013
    ..The studies proposed in this application will help us better understand how this pathogen escapes killing by complement and will ultimately aid in the development of better vaccines against meningococcal meningitis. ..
  7. Role of ABCG1 in lipid homeostasis, inflammation and innate immunity
    ELIZABETH JOANNA TARLING; Fiscal Year: 2013
    ....
  8. Phosphorylation Events During Sperm Capacitation
    PABLO EDUARDO VISCONTI; Fiscal Year: 2013
    ..Accomplishment of these goals will lead to novel insights in clinical diagnosis of male infertility and provide tools for evaluating pharmacological contraceptive targets. ..
  9. Targeting of alpha7 nAChR for therapeutic effects
    Roger L Papke; Fiscal Year: 2013
    ..We will use our new discoveries about how these drugs work to help make alpha7-stimulating drugs optimally designed to treat specific diseases. ..
  10. TERPENE CONDENSATION REACTIONS
    CHARLES POULTER; Fiscal Year: 2009
    ..This approach can also be used to regio- and chemoselectively attach proteins to other molecules, and offers a new approach for synthesis of clinically useful protein-polyethylene glycol conjugates. ..
  11. Role of mucin-type O-glycosylation in Trypanosoma cruzi biology
    Christopher M West; Fiscal Year: 2012
    ....
  12. Homogenous HTS Assays to Screen for Inhibitors of Keap1-Nrf2 Interaction
    Longqin Hu; Fiscal Year: 2010
    ..Specific and potent Keap1-Nrf2 inhibitors will be useful as important pharmacological probes for the elucidation of cytoprotective pathways and as potential cancer chemopreventive agents in high risk populations. ..
  13. Targeting the Foam Cell to Prevent Atherosclerosis
    ANTONIO PAUL; Fiscal Year: 2013
    ....
  14. Nano-Antioxidants as a Therapeutic for Preclinical Models of NAFLD
    Robia G Pautler; Fiscal Year: 2013
    ..The rationale for the proposed work is that a mechanistic understanding of oxidative stress on NAFLD pathologies will lay the foundation for viable therapeutic approaches. ..
  15. Hepatic Cholesteryl Ester Metabolism and Cholesterol Elimination
    Shobha Ghosh; Fiscal Year: 2013
    ..Aim 4: To obtain in vivo "proof of concept" by liver-specific targeted disruption of CEH in mice and to determine its effect on intracellular CE metabolism and atherosclerosis. ..
  16. Enhanced Provision of Male Circumcision for HIV Prevention, Rakai, Uganda
    Ronald H Gray; Fiscal Year: 2013
    ..The impact of MC on HIV incidence, cost-effectiveness and enhanced modeling (Aim 3) will provide data on population prevention of HIV through MC, for policy and program development. ..
  17. Enhancing Kidney Donation Through Live Organ Video Educated Donors (LOVED)
    Frank A Treiber; Fiscal Year: 2013
    ..These experiences will foster increased efficacy and motivation to complete the LDKT process as a patient or donor. ..
  18. Integration of redox-balancing mechanisms in Pseudomonas aeruginosa biofilms
    Lars Dietrich; Fiscal Year: 2013
    ..aeruginosa integrates environmental cues to support growth and survival in a crowded structure may be broadly applicable to many bacterial pathogens and have the potential to inform future therapeutic considerations. ..
  19. Assembly of bacterial cytoplasmic protein complexes measured by LRET
    ROBERT D RENTHAL; Fiscal Year: 2013
    ..This information will aid future targeting of these structures to weaken the pathogenic effects of enterobacteria. ..
  20. Sulfur Assimilation Pathway: New Antifungal Targets
    GEORGE ROBERT NEWPORT; Fiscal Year: 2010
    ....
  21. Characterization of redox-mediated protein in mitochondria
    SONYA ELINA NEAL; Fiscal Year: 2013
    ..This proposal will provide insight into fundamental pathways in mitochondrial assembly that are impaired in the disease state. ..
  22. Assembly Line Biosynthesis of Bacterial Siderophores
    FRED L HEFFRON; Fiscal Year: 2012
    ..These approaches will likely lead to the exploration of new avenues in the process of siderophore biosynthesis and virulence in bacteria. ..
  23. ApoE and SR-BI as Determinants of HDL and Macrophage Function in Atherogenesis
    Macrae F Linton; Fiscal Year: 2010
    ..New insights into the roles of apoE and SR-BI as determinants of the anti-atherogenic functions of HDL cholesterol and macrophage cholesterol homeostasis and apoptosis may lead to new therapeutic approaches for atherosclerosis. ..
  24. Characterizing a novel hemophore from pathogenic and non-pathogenic mycobacteria.
    LISA M MCMATH; Fiscal Year: 2010
    ..We have shifted this paradigm, as we have identified a novel iron acquisition pathway whereby iron is obtained via the uptake of human heme, opening up new avenues for anti-TB drug development. ..
  25. Assay for GI Drug Discovery
    LID WONG; Fiscal Year: 2012
    ..These novel assays will also provide unparallel insights in the ionic cellular signal transduction mechanisms that heretofore not been possible. ..
  26. Mechanisms of Copper Transport
    Ninian J Blackburn; Fiscal Year: 2013
    ..These studies will lead to a better understanding of the molecular basis of copper trafficking and will aid in combating diseases of aberrant copper homeostasis. ..
  27. Hoogsteen base pairing in human DNA polymerase iota
    Satya Prakash; Fiscal Year: 2010
    ..abstract_text> ..
  28. MODULATION OF T LYMPHOCYTE REGULATION
    Christian LeGuern; Fiscal Year: 2009
    ..abstract_text> ..
  29. Evaluation of Web-Based CBT for Rape Victims
    Heather Littleton; Fiscal Year: 2013
    ..Finally, because the treatment involves structured modules, it can rapidly be disseminated and adopted in the field. ..
  30. Circumcision: HIV/STIs and behaviors in a RCT and post-RCT surveillance;Rakai
    Ronald H Gray; Fiscal Year: 2011
    ..We thus propose to assess the long term individual and community effects of circumcision. In this proposal, we request funds for follow-up of NIH trial participants. RCCS participants will be supported by other funding. ..
  31. Establishing the Molecular Basis of Glycoconjugate Glycosylation
    James Prestegard; Fiscal Year: 2013
    ..The information will be essential in extrapolating molecular level specificities to action of enzyme-based reagents in vivo. ..
  32. Functional Analysis of a Digestive-Tract Microbiome During Dietary Changes
    Pieter T Visscher; Fiscal Year: 2013
    ....
  33. Solution-Phase Automated Synthesis of Oligosaccharides
    Nicola L Pohl; Fiscal Year: 2010
    ..g. mucopolysaccharidosis). This proposal will develop methods for the first rapid automated assembly of oligosaccharides in solution for use in medical diagnostics and basic science studies. ..
  34. Adherent Invasive E. coli and colitis
    ANDREAS J BAUMLER; Fiscal Year: 2013
    ..coli in the gut lumen. ..
  35. PhotoMorph3 and PhotoPS3 - Novel Light-Activated Antisense Agents
    John A Zebala; Fiscal Year: 2010
    ..We now aim to further develop and commercialize a new generation of photoactivatable chemicals for doing this (PhotoMorph3.0" and PhotoPS3.0") that we believe will offer important advantages over others. ..
  36. PLATELET ACTIVATING FACTOR DEPENDENT TRANSACETYLASES
    TEN CHING LEE; Fiscal Year: 1999
    ..Obtaining such information could ultimately be used to modify some of the adverse biological consequences elicited by PAF. ..
  37. GTP IN PHOSPHOLIPASE ACTIVATION AND INSULIN RELEASE
    STEWART METZ; Fiscal Year: 2000
    ..Such findings may have applicability to the understanding of endocrine secretion in general and, ultimately, to hypersecretory states such as diabetes mellitus, specifically. ..
  38. SPECTROSCOPIC STUDIES OF ENZYME/SUBSTRATE COMPLEXES
    George Reed; Fiscal Year: 2007
    ..The transient-phase kinetic approach with isotopes will provide new insight into the mechanism of the hydrogen atom abstraction steps in the catalytic cycle. ..
  39. Molecular Mechanism and In Vivo Study of ER Associated Degradation
    Lenka Kundrat; Fiscal Year: 2012
    ..Because many diseases have been attributed to the accumulation of misfolded proteins, the proposed experiments are relevant to numerous diseases. ..
  40. Discovery of A-beta Oligomer Antagonists via 3D Pharmacophore Space Analysis
    CHRISTIAN ALEXANDER LANG; Fiscal Year: 2012
    ..The outcome of this study will be new drug leads to potentially treat and prevent AD at different stages of cognitive decline and neurodegeneration. ..
  41. Validating NT17 Dependent Mechanisms in Huntington's Disease Suppression
    Xiangdong William Yang; Fiscal Year: 2013
    ..Our study may provide novel therapeutic insights based on the NT17 domain and its interacting proteins to ameliorate nuclear mhtt toxicity and prevent the onset of movement disorder and neurodegeneration in HD. ..
  42. RCT of a Novel Oral Contraceptive Initiation Method
    Carolyn Westhoff; Fiscal Year: 2004
    ..We will also assess dual method use for STD prevention in the study to adoption of and adherence to oral contraceptives. We will also assess dual method use for STD prevention in the study population. ..
  43. OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTION
    Charles Myers; Fiscal Year: 2002
    ..They will also contribute to environmental health by expanding our knowledge on the mechanisms by which manganese, iron, and various heavy metals are mobilized into water supplies. ..
  44. Structural Studies on Cytochromes P450 and Related Proteins
    THOMAS LEWIS POULOS; Fiscal Year: 2013
    ..Especially important is the role played by P450s in drug metabolism, cancer, and the biosynthesis of critical steroid intermediates and antibiotics. ..
  45. ASSEMBLY OF A MEMBRANE-BOUND MULTI-ENZYME COMPLEX
    JOHN DE MOSS; Fiscal Year: 1993
    ....
  46. Structure and function of family 1 glycosyltransferases
    R Garavito; Fiscal Year: 2006
    ..Mixing hybrid enzyme design with combinatorial biosynthesis could provide practical ways to produce new glycoconjugates of biomedical importance. ..
  47. PID IN IUD VS INJECTABLE CONTRACEPTIVE USERS PILOT STUDY
    Paul Feldblum; Fiscal Year: 2001
    ..The applicant must detect evidence of moderate STD prevalence and PID incidence in the cohorts. ..
  48. BIOTINIDASE AND ITS ROLE IN BIOTIN METABOLISM
    Barry Wolf; Fiscal Year: 1999
    ..In addition, the proposed research will provide a better understanding of the role of biotinidase in biotin metabolism and will be a paradigm for understanding the metabolism of other vitamins. ..
  49. Study Of Mycobacterial Galactan Biosynthesis By Chemoenzymatic Substrate Assembly
    Mario A Martinez Farias; Fiscal Year: 2013
    ..These studies will clarify the role of GlfT1 in galactan assembly. We shall then probe GlfT2 polymerization with the products of GlfT1 catalysis. ..
  50. Molecular Characterization of Aquifer Microbial Communi*
    Kate Scow; Fiscal Year: 2004
    ..We will conduct studies in microcosms and across pollutant gradients (of BTEX, BTEX + MTBE or ethanol) at a field site containing a petroleum spill (with BTEX and MTBE) at Vandenberg Air Force Base in CA. ..
  51. TESTICULAR STEROIDOGENESIS IN SELECTED MODELS
    GLORIA CALLARD; Fiscal Year: 1992
    ..Studies in this laboratory show the feasibility of using animal models outside the range of common laboratory species to advance materially our understanding of testicular endocrinology...
  52. EFFECT OF LASER RADIATION ON PERIODONTOPATHIC BACTERIA
    CLAY HENRY; Fiscal Year: 1990
    ....
  53. HUMAN FUCOSYLTRANSFERASE STRUCTURE/FUNCTION ANALYSIS
    Eric Holmes; Fiscal Year: 2001
    ....
  54. FAMILIAL ALS--MECHANISM OF INITIATION
    Dale Bredesen; Fiscal Year: 1999
    ....
  55. PHASE-RESOLVED FLUORESCENCE STUDIES OF PROTEIN DYNAMICS
    PATRICIA O HARA; Fiscal Year: 1993
    ..Again, energy transfer studies such as those described above will be used to give insight into the dynamics of this dramatic conformational change. ..
  56. Nitrate respiration by Salmonella during gut inflammation
    Sebastian E Winter; Fiscal Year: 2013
    ..e. that the evolution of Salmonella may be driven by making new nutrients such as anaerobic respiratory electron acceptors available in the inflamed gut, thus boosting transmission success. ..
  57. Novel Alkylglycosides with Anti-Diabetic Activity
    NICHOLAS CAIRNS; Fiscal Year: 2005
    ..Testing of the Alkylmaltosides as Substrates for the Glycogen Biosynthetic Enzymes 4. Determine the Effects of the Most Active O- and/or S-Alkylmaltosides on Blood Glucose and Glucose tolerance in the ob/ob Mouse Model. ..
  58. A FRET-based assay to measure dynamic changes in RyR1 structure
    JAMES FESSENDEN; Fiscal Year: 2009
    ..This technique will open the door for further structural measurements of RyR1 to determine how disease-causing mutations alter the structure of the channel. ..
  59. BACTERIORHODOPSIN CHROMOPHORE STRUCTURE BY DEUTERIUM NMR
    MAARTEN HEYN; Fiscal Year: 1999
    ..An investigation of the analogous steps in the M intermediate of bR is expected to contribute to an understanding of the mechanism of activation of rhodopsin in visual signal transduction. ..
  60. MECHANISTIC STUDIES OF PROKARYOTIC MANNOSYLTRANSFERASES
    JON THORSON; Fiscal Year: 2002
    ....
  61. CELLULAR ACTION OF ALKYLGLYCOSIDES AS GLYCOGEN PRIMERS
    Elias Meezan; Fiscal Year: 2000
    ..These studies may have therapeutic implications for modulating the disposal of glucose in diabetes. ..
  62. STUDIES ON RHODOPSIN & AGE-RELATED MACULAR DEGENERATION
    Koji Nakanishi; Fiscal Year: 2006
    ..abstract_text> ..
  63. ULTRAPOTENT PARS INHIBITOR FOR CARDIOPROTECTION
    John van Duzer; Fiscal Year: 2000
    ..PROPOSED COMMERCIAL APPLICATIONS: The annual anticipated revenue for an effective therapeutic to prevent and treat myocardial reperfusion injury is estimated at > $1 billion in the US per annum. ..