naproxen

Summary

Summary: An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.

Top Publications

  1. Fan W, Wu Y, Li X, Yao N, Li X, Yu Y, et al. Design, synthesis and biological evaluation of brain-specific glucosyl thiamine disulfide prodrugs of naproxen. Eur J Med Chem. 2011;46:3651-61 pubmed publisher
    ..To overcome this defect, glucosyl thiamine disulfide prodrugs 1a-1c incorporating naproxen were designed and synthesized. Furthermore, prodrug 2 and 3 were also prepared as control...
  2. Ustündağ Okur N, Apaydin S, Karabay Yavasoglu N, Yavasoglu A, Karasulu H. Evaluation of skin permeation and anti-inflammatory and analgesic effects of new naproxen microemulsion formulations. Int J Pharm. 2011;416:136-44 pubmed publisher
    ..aim of this study was to evaluate the potential application of microemulsions as a transdermal drug delivery for naproxen (Np)...
  3. Yilmaz E, Can K, Sezgin M, Yilmaz M. Immobilization of Candida rugosa lipase on glass beads for enantioselective hydrolysis of racemic naproxen methyl ester. Bioresour Technol. 2011;102:499-506 pubmed publisher
    ..5 times higher than that of the covalently immobilized lipase. The enantioselective hydrolysis of racemic Naproxen methyl ester by immobilized lipase was studied in aqueous buffer solution/isooctane reaction system and it was ..
  4. Miner P, Plachetka J, Orlemans E, Fort J, Sostek M. Clinical trial: evaluation of gastric acid suppression with three doses of immediate-release esomeprazole in the fixed-dose combination of PN 400 (naproxen/esomeprazole magnesium) compared with naproxen 500 mg and enteric-coated esomeprazole 20 mg: a. Aliment Pharmacol Ther. 2010;32:414-24 pubmed publisher
    PN 400 is a fixed-dose combination formulated to provide sequential delivery of immediate-release (IR) esomeprazole and enteric-coated (EC) naproxen.
  5. Suthisisang C, Poolsup N, Suksomboon N, Lertpipopmetha V, Tepwitukgid B. Meta-analysis of the efficacy and safety of naproxen sodium in the acute treatment of migraine. Headache. 2010;50:808-18 pubmed publisher
    To assess the efficacy and safety of naproxen sodium in the treatment of acute migraine attacks. Non-steroidal anti-inflammatory drugs including naproxen sodium have been used in treating migraine attack...
  6. Wallace J, Syer S, Denou E, De Palma G, Vong L, McKnight W, et al. Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology. 2011;141:1314-22, 1322.e1-5 pubmed publisher
    ..doses of omeprazole or lanzoprazole for 9 days, with concomitant treatment with anti-inflammatory doses of naproxen or celecoxib on the final 4 days...
  7. Wang B, Jiang W, Yan H, Zhang X, Yang L, Deng L, et al. Novel PEG-graft-PLA nanoparticles with the potential for encapsulation and controlled release of hydrophobic and hydrophilic medications in aqueous medium. Int J Nanomedicine. 2011;6:1443-51 pubmed publisher
    ..One hydrophilic (insulin) and one hydrophobic (naproxen) model medication were loaded in separately during its self-assembly in aqueous solution...
  8. Kayaert P, Van den Mooter G. An investigation of the adsorption of hydroxypropylmethyl cellulose 2910 5 mPa s and polyvinylpyrrolidone K90 around Naproxen nanocrystals. J Pharm Sci. 2012;101:3916-23 pubmed publisher
    ..hydroxypropylmethyl cellulose (HPMC) 2910 5 mPa s and polyvinylpyrrolidone (PVP) K90] with the surface of Naproxen crystals...
  9. Cipriano M, Björklund E, Wilson A, Congiu C, Onnis V, Fowler C. Inhibition of fatty acid amide hydrolase and cyclooxygenase by the N-(3-methylpyridin-2-yl)amide derivatives of flurbiprofen and naproxen. Eur J Pharmacol. 2013;720:383-90 pubmed publisher
    ..Here we present data on the N-(3-methylpyridin-2-yl)amide derivatives of flurbiprofen and naproxen (Flu-AM1 and Nap-AM1, respectively) with respect to their properties towards these two enzymes...

Scientific Experts

More Information

Publications62

  1. Sakaguchi Y, Yoshida H, Hayama T, Yoshitake M, Itoyama M, Todoroki K, et al. Fluorous derivatization and fluorous-phase separation for fluorometric determination of naproxen and felbinac in human plasma. J Pharm Biomed Anal. 2011;55:176-80 pubmed publisher
    ..b>Naproxen and felbinac, widely used native-fluorescent NSAIDs with a carboxyl group, can have toxic effects at acute doses, ..
  2. Hautaniemi T, Petrenko N, Skorinkin A, Giniatullin R. The inhibitory action of the antimigraine nonsteroidal anti-inflammatory drug naproxen on P2X3 receptor-mediated responses in rat trigeminal neurons. Neuroscience. 2012;209:32-8 pubmed publisher
    ..In this study, we tested whether naproxen, a common antimigraine medicine, could affect the function of P2X3 receptors in the presence or absence of the ..
  3. Krekels E, Angesjö M, Sjögren I, Möller K, Berge O, Visser S. Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats. Pharm Res. 2011;28:1561-76 pubmed publisher
    To quantify and compare the time-course and potency of the analgesic and antipyretic effects of naproxen in conjunction with the inhibition of PGE(2) and TXB(2)...
  4. Lal R, Sukbuntherng J, Luo W, Vicente V, Blumenthal R, Ho J, et al. Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine. Br J Clin Pharmacol. 2010;69:498-507 pubmed publisher
    ..of gabapentin enacarbil were evaluated in healthy adults after administration alone or in combination with either naproxen (an MCT-1 substrate) or cimetidine (an OCT2 substrate)...
  5. Friedman B, Solorzano C, Esses D, Xia S, Hochberg M, Dua N, et al. Treating headache recurrence after emergency department discharge: a randomized controlled trial of naproxen versus sumatriptan. Ann Emerg Med. 2010;56:7-17 pubmed publisher
    ..The aim of this study is to compare the efficacy of oral sumatriptan with naproxen for treatment of post-ED recurrent primary headache. This was a randomized, double-blind efficacy trial...
  6. Walton S, Schumock G, McLain D. Cost analysis of flavocoxid compared to naproxen for management of mild to moderate OA. Curr Med Res Opin. 2010;26:2253-61 pubmed publisher
    ..A decision model was developed to estimate the total costs associated with flavocoxid versus naproxen for the management of Medicare patients with mild to moderate OA...
  7. Lynd L, Marra C, Najafzadeh M, Sadatsafavi M. A quantitative evaluation of the regulatory assessment of the benefits and risks of rofecoxib relative to naproxen: an application of the incremental net-benefit framework. Pharmacoepidemiol Drug Saf. 2010;19:1172-80 pubmed publisher
    To undertake a quantitative benefit-risk analysis of rofecoxib relative to naproxen using an incremental net-benefit (INB) analysis from the societal perspective, using the same data evaluated by the Health Canada and US FDA expert ..
  8. Schjerning Olsen A, Fosbøl E, Lindhardsen J, Folke F, Charlot M, Selmer C, et al. Duration of treatment with nonsteroidal anti-inflammatory drugs and impact on risk of death and recurrent myocardial infarction in patients with prior myocardial infarction: a nationwide cohort study. Circulation. 2011;123:2226-35 pubmed publisher
    ..Neither short- nor long-term treatment with NSAIDs is advised in this population, and any NSAID use should be limited from a cardiovascular safety point of view. ..
  9. Ortiz M, Ramírez Montiel M, González García M, Ponce Monter H, Castaneda Hernandez G, Cariño Cortés R. The combination of naproxen and citral reduces nociception and gastric damage in rats. Arch Pharm Res. 2010;33:1691-7 pubmed publisher
    ..Therefore, the aim of this study was to examine the effects of the interaction between naproxen and citral on nociception and gastric injury in rats...
  10. Vrbata P, Berka P, Stranska D, Dolezal P, Musilová M, Cižinská L. Electrospun drug loaded membranes for sublingual administration of sumatriptan and naproxen. Int J Pharm. 2013;457:168-76 pubmed publisher
    ..Sumatriptan succinate, naproxen, and its salt as well as combinations of these were incorporated into nanofibrous membranes via the ..
  11. Bracchitta G, Catalfo A, Martineau S, Sage E, De Guidi G, Girard P. Investigation of the phototoxicity and cytotoxicity of naproxen, a non-steroidal anti-inflammatory drug, in human fibroblasts. Photochem Photobiol Sci. 2013;12:911-22 pubmed publisher
    ..b>Naproxen, 2-(6-methoxy-2-naphthyl) propionic acid (NAP), belongs to this pharmacological class and appears to be ..
  12. Jung J, Park M, Park H, Shim S, Cho Y, Kim J, et al. ¹H NMR-based metabolic profiling of naproxen-induced toxicity in rats. Toxicol Lett. 2011;200:1-7 pubmed publisher
    The dose-dependent perturbations in urinary metabolite concentrations caused by naproxen toxicity were investigated using ¹H NMR spectroscopy coupled with multivariate statistical analysis...
  13. Horbach S, Lopes R, da C Guaragna J, Martini F, Mehta R, Petracco J, et al. Naproxen as prophylaxis against atrial fibrillation after cardiac surgery: the NAFARM randomized trial. Am J Med. 2011;124:1036-42 pubmed publisher
    We sought to assess the effect of naproxen versus placebo on prevention of atrial fibrillation after coronary artery bypass graft (CABG) surgery...
  14. Honjo H, Uwai Y, Aoki Y, Iwamoto K. Stereoselective inhibitory effect of flurbiprofen, ibuprofen and naproxen on human organic anion transporters hOAT1 and hOAT3. Biopharm Drug Dispos. 2011;32:518-24 pubmed publisher
    ..laevis oocytes to assess stereoselectivity in the inhibitory characteristics of flurbiprofen, ibuprofen and naproxen against hOAT1 and hOAT3...
  15. Durán Álvarez J, Prado Pano B, Jiménez Cisneros B. Sorption and desorption of carbamazepine, naproxen and triclosan in a soil irrigated with raw wastewater: estimation of the sorption parameters by considering the initial mass of the compounds in the soil. Chemosphere. 2012;88:84-90 pubmed publisher
    ..In this study, the sorption of naproxen, carbamazepine and triclosan was determined in a wastewater irrigated soil, considering the initial mass of the ..
  16. Melvin S, Cameron M, Lanctôt C. Individual and mixture toxicity of pharmaceuticals naproxen, carbamazepine, and sulfamethoxazole to Australian striped marsh frog tadpoles (Limnodynastes peronii). J Toxicol Environ Health A. 2014;77:337-45 pubmed publisher
    ..loss of tactile response) of striped marsh frog (Limnodynastes peronii) tadpoles exposed to a mixture of naproxen, carbamazepine, and sulfamethoxazole, compared to exposures to the individual compounds...
  17. Dhillon S. Naproxen/esomeprazole fixed-dose combination: for the treatment of arthritic symptoms and to reduce the risk of gastric ulcers. Drugs Aging. 2011;28:237-48 pubmed publisher
    b>Naproxen/esomeprazole is a fixed-dose combination of the NSAID naproxen and the proton pump inhibitor esomeprazole...
  18. Martin V, Ballard J, Diamond M, Mannix L, Derosier F, Lener S, et al. Relief of menstrual symptoms and migraine with a single-tablet formulation of sumatriptan and naproxen sodium. J Womens Health (Larchmt). 2014;23:389-96 pubmed publisher
    ..controlled trials of 621 adult menstrual migraineurs with dysmenorrhea who treated migraine with sumatriptan-naproxen or placebo...
  19. Silva R, Santana A, Carvalho N, Bezerra T, Oliveira C, Damasceno S, et al. A sulfated-polysaccharide fraction from seaweed Gracilaria birdiae prevents naproxen-induced gastrointestinal damage in rats. Mar Drugs. 2012;10:2618-33 pubmed
    ..to evaluate the protective effect of the PLS fraction extracted from the seaweed Gracilaria birdiae in rats with naproxen-induced gastrointestinal damage. Male Wistar rats were pretreated with 0...
  20. Essex M, Bhadra P, Sands G. Efficacy and tolerability of celecoxib versus naproxen in patients with osteoarthritis of the knee: a randomized, double-blind, double-dummy trial. J Int Med Res. 2012;40:1357-70 pubmed
    To assess the efficacy and tolerability of celecoxib versus naproxen in patients with osteoarthritis (OA) of the knee. This 6-month, randomized, double-blind, double-dummy trial was conducted at 47 centres in the USA...
  21. Ortiz M, González García M, Ponce Monter H, Castaneda Hernandez G, Aguilar Robles P. Synergistic effect of the interaction between naproxen and citral on inflammation in rats. Phytomedicine. 2010;18:74-9 pubmed publisher
    ..was to examine the effects on inflammation and gastric injury in rats resulting from the interaction between naproxen and citral...
  22. Rodrigues M, Lanzarini C, Ricci Junior E. Preparation, in vitro characterization and in vivo release of naproxen loaded in poly-caprolactone nanoparticles. Pharm Dev Technol. 2011;16:12-21 pubmed publisher
    b>Naproxen was loaded in poly-caprolactone (PCL) nanoparticles as an implantable sustained release system to prolong its anti-inflammatory activity...
  23. White W, Schnitzer T, Fleming R, Duquesroix B, Beekman M. Effects of the cyclooxygenase inhibiting nitric oxide donator naproxcinod versus naproxen on systemic blood pressure in patients with osteoarthritis. Am J Cardiol. 2009;104:840-5 pubmed publisher
    ..To assess the potential impact of nitric oxide donation, the effects of naproxcinod with naproxen and placebo on changes in BP were compared in a randomized clinical trial of 916 patients with osteoarthritis ..
  24. Karabayirli S, Ayrım A, Muslu B. Comparison of the analgesic effects of oral tramadol and naproxen sodium on pain relief during IUD insertion. J Minim Invasive Gynecol. 2012;19:581-4 pubmed publisher
    To compare the analgesic efficacy of oral tramadol and naproxen sodium on pain during insertion of an intrauterine device (IUD).
  25. Sheha M. Pharmacokinetic and ulcerogenic studies of naproxen prodrugs designed for specific brain delivery. Arch Pharm Res. 2012;35:523-30 pubmed publisher
    b>Naproxen (Nap) is an NSAID used as a neuroprotective agent to treat several neurodegenerative diseases. The observed limited brain bioavailability of the drug prompted the design of several chemical delivery systems...
  26. Zhang W, Gao J, Zhao T, Wu W, Bai Y, Zou D, et al. High-dose naproxen aggravates pancreatic fibrosis in a rat model of chronic pancreatitis. Pancreas. 2010;39:293-300 pubmed publisher
    ..Chronic pancreatitis was induced by trinitrobenzene sulfonic acid infusion into rat pancreatic ducts. Naproxen treatment (20 and 40 mg/kg per os [PO] and intraperitoneally) started 2 weeks after the induction of CP for 3 ..
  27. Kumar B, Tiwari S, Saikant R, Manoj G, Kunwar A, Sivaram G, et al. Antibacterial and ulcer healing effects of organoselenium compounds in naproxen induced and Helicobacter pylori infected Wistar rat model. J Trace Elem Med Biol. 2010;24:263-70 pubmed publisher
    ..05) ulcer healing property supporting its role in gastro protection. In conclusion, the results of our study suggest that both SeCys and Ebs possess broad spectrum of activities without any potential toxicity. ..
  28. Shin B, Baek E, Choi S, Davaa E, Nho Y, Lim Y, et al. Preparation and irradiation of Pluronic F127-based thermoreversible and mucoadhesive hydrogel for local delivery of naproxen. Drug Dev Ind Pharm. 2013;39:1874-80 pubmed publisher
    ..As a model drug, naproxen was loaded in the hydrogel formulation...
  29. Steele V, Rao C, Zhang Y, Patlolla J, Boring D, Kopelovich L, et al. Chemopreventive efficacy of naproxen and nitric oxide-naproxen in rodent models of colon, urinary bladder, and mammary cancers. Cancer Prev Res (Phila). 2009;2:951-6 pubmed publisher
    ..However, certain NSAIDs cause gastrointestinal ulceration and may increase cardiovascular events. Naproxen seems to cause the lowest cardiovascular events of the common NSAIDs other than aspirin...
  30. Wallace J, Caliendo G, Santagada V, Cirino G. Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346). Br J Pharmacol. 2010;159:1236-46 pubmed publisher
    ..the gastrointestinal safety and anti-inflammatory efficacy of a novel hydrogen sulphide-releasing derivative of naproxen, ATB-346 [2-(6-methoxy-napthalen-2-yl)-propionic acid 4-thiocarbamoyl-phenyl ester]...
  31. Duggan K, Walters M, Musee J, Harp J, Kiefer J, Oates J, et al. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J Biol Chem. 2010;285:34950-9 pubmed publisher
    b>Naproxen ((S)-6-methoxy-?-methyl-2-naphthaleneacetic acid) is a powerful non-selective non-steroidal anti-inflammatory drug that is extensively used as a prescription and over-the-counter medication...
  32. Cady R, O Carroll P, Dexter K, Freitag F, Shade C. SumaRT/Nap vs naproxen sodium in treatment and disease modification of migraine: a pilot study. Headache. 2014;54:67-79 pubmed publisher
    ..study explored the potential for 2 recognized acute migraine medications, 85?mg of sumatriptan plus 500?mg of naproxen sodium in a combination tablet (SumaRT/Nap) and 500?mg of naproxen sodium, to treat and modify the disease ..
  33. Ando S, Kikuchi J, Fujimura Y, Ida Y, Higashi K, Moribe K, et al. Physicochemical characterization and structural evaluation of a specific 2:1 cocrystal of naproxen-nicotinamide. J Pharm Sci. 2012;101:3214-21 pubmed publisher
    Physicochemical characterization and structural evaluation of a 2:1 naproxen-nicotinamide cocrystal were performed...
  34. Smit J, Oh C, Rengelshausen J, Terlinden R, Ravenstijn P, Wang S, et al. Effects of acetaminophen, naproxen, and acetylsalicylic acid on tapentadol pharmacokinetics: results of two randomized, open-label, crossover, drug-drug interaction studies. Pharmacotherapy. 2010;30:25-34 pubmed publisher
    To evaluate the effects of acetaminophen, naproxen, and acetylsalicylic acid on the pharmacokinetics of the centrally acting analgesic tapentadol in healthy subjects. Two randomized, open-label, crossover, drug-drug interaction studies...
  35. Puglia C, Bonina F, Rizza L, Cortesi R, Merlotti E, Drechsler M, et al. Evaluation of percutaneous absorption of naproxen from different liposomal formulations. J Pharm Sci. 2010;99:2819-29 pubmed publisher
    The present study concerns the percutaneous absorption of naproxen (NPX), as model anti-inflammatory drug, included in liposome formulations constituted of different lipids: stratum corneum lipids (SCL) and phosphatidylcholine/cholesterol ..
  36. Manrique Moreno M, Suwalsky M, Villena F, Garidel P. Effects of the nonsteroidal anti-inflammatory drug naproxen on human erythrocytes and on cell membrane molecular models. Biophys Chem. 2010;147:53-8 pubmed publisher
    b>Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), has been widely investigated in terms of its pharmacological action, but less is known about its effects on cell membranes and particularly those of human erythrocytes...
  37. González Béjar M, Alarcon E, Poblete H, Scaiano J, Pérez Prieto J. Stereoselective interaction of epimeric naproxen-RGD peptides with human serum albumin. Biomacromolecules. 2010;11:2255-60 pubmed publisher
    ..of the interaction between human serum albumin (HSA) and two epimeric bioconjugates, which contain (S)- or (R)-naproxen (NPX) bound to a cyclopentapeptide with an arginine-glycine-aspartate sequence (cRGD), on the absolute ..
  38. Sostek M, Fort J, Estborn L, Vikman K. Long-term safety of naproxen and esomeprazole magnesium fixed-dose combination: phase III study in patients at risk for NSAID-associated gastric ulcers. Curr Med Res Opin. 2011;27:847-54 pubmed publisher
    To evaluate long-term safety of enteric-coated naproxen 500?mg and immediate-release esomeprazole magnesium 20?mg fixed-dose combination (FDC) in patients at risk of NSAID-associated upper gastrointestinal (UGI) ulcers...
  39. Hochberg M, Fort J, Svensson O, Hwang C, Sostek M. Fixed-dose combination of enteric-coated naproxen and immediate-release esomeprazole has comparable efficacy to celecoxib for knee osteoarthritis: two randomized trials. Curr Med Res Opin. 2011;27:1243-53 pubmed publisher
    To demonstrate that a fixed-dose combination of enteric-coated naproxen 500?mg and immediate-release esomeprazole magnesium 20?mg has comparable efficacy to celecoxib for knee osteoarthritis...
  40. Ouyang L, Ma L, Jiang B, Li Y, He D, Guo L. Synthesis of novel dendrimers having aspartate grafts and their ability to enhance the aqueous solubility of model drugs. Eur J Med Chem. 2010;45:2705-11 pubmed publisher
    ..The aqueous solubility of the model drugs (L-Histidine, Naproxen, Methotrexate) was measured in the presence of this kind of dendrimers at room temperature in PBS buffers at pH 6,..
  41. Peloso P, Gammaitoni A, Smugar S, Wang H, Moore A. Longitudinal numbers-needed-to-treat (NNT) for achieving various levels of analgesic response and improvement with etoricoxib, naproxen, and placebo in ankylosing spondylitis. BMC Musculoskelet Disord. 2011;12:165 pubmed publisher
    ..analysis of a 6-week, randomized, double-blind study (N = 387) comparing etoricoxib 90 mg, etoricoxib 120 mg, naproxen 1000 mg, and placebo in AS. Spine pain and BASDAI were measured on a 100-mm visual analog scale...
  42. Goldstein J, Hochberg M, Fort J, Zhang Y, Hwang C, Sostek M. Clinical trial: the incidence of NSAID-associated endoscopic gastric ulcers in patients treated with PN 400 (naproxen plus esomeprazole magnesium) vs. enteric-coated naproxen alone. Aliment Pharmacol Ther. 2010;32:401-13 pubmed publisher
    ..Gastroprotective co-therapy may reduce the risk of nonsteroidal anti-inflammatory drug (NSAID)-associated gastric ulcers, but adherence is suboptimal...
  43. Javadzadeh Y, Ahadi F, Davaran S, Mohammadi G, Sabzevari A, Adibkia K. Preparation and physicochemical characterization of naproxen-PLGA nanoparticles. Colloids Surf B Biointerfaces. 2010;81:498-502 pubmed publisher
    b>Naproxen is a non-steroidal anti-inflammatory drug which can be used for the treatment of inflammatory disorders like uveitis and arthirit rheumatoid...
  44. Baerwald C, Verdecchia P, Duquesroix B, Frayssinet H, Ferreira T. Efficacy, safety, and effects on blood pressure of naproxcinod 750 mg twice daily compared with placebo and naproxen 500 mg twice daily in patients with osteoarthritis of the hip: a randomized, double-blind, parallel-group, multicenter study. Arthritis Rheum. 2010;62:3635-44 pubmed publisher
    ..multicenter study, 810 patients were randomized to receive either naproxcinod 750 mg twice daily, placebo, or naproxen 500 mg twice daily (2:2:1)...
  45. Levy R, Khokhlov A, Kopenkin S, Bart B, Ermolova T, Kantemirova R, et al. Efficacy and safety of flavocoxid compared with naproxen in subjects with osteoarthritis of the knee- a subset analysis. Adv Ther. 2010;27:953-62 pubmed publisher
    ..of botanical origin, was evaluated for 12 weeks in a randomized, double-blind, active-comparator study against naproxen in 220 subjects with moderate-severe osteoarthritis (OA) of the knee...
  46. Levy R, Khokhlov A, Kopenkin S, Bart B, Ermolova T, Kantemirova R, et al. Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee. Adv Ther. 2010;27:731-42 pubmed publisher
    ..This study was designed to compare the effectiveness and safety of flavocoxid to naproxen in subjects with moderate to severe osteoarthritis (OA) of the knee...
  47. Levy R, Saikovsky R, Shmidt E, Khokhlov A, Burnett B. Flavocoxid is as effective as naproxen for managing the signs and symptoms of osteoarthritis of the knee in humans: a short-term randomized, double-blind pilot study. Nutr Res. 2009;29:298-304 pubmed publisher
    ..molecules (baicalin and catechin), was tested against a traditional nonsteroidal anti-inflammatory drug, naproxen, for the management of the signs and symptoms of moderate osteoarthritis (OA) in humans...
  48. Straub J, Stewart K. Deterministic and probabilistic acute-based environmental risk assessment for naproxen for western Europe. Environ Toxicol Chem. 2007;26:795-806 pubmed
    An environmental risk assessment (ERA) was made for the common nonsteroidal anti-inflammatory drug naproxen. The ERA was performed according to deterministic and probabilistic methods, based on different predicted environmental ..
  49. Garcia Reyes J, Ortega Barrales P, Molina Diaz A. Multicommuted fluorometric multiparameter sensor for simultaneous determination of naproxen and salicylic acid in biological fluids. Anal Sci. 2007;23:423-8 pubmed
    ..principles has been applied to develop a method for the simultaneous analysis of two pharmaceuticals (naproxen and salicylic acid) in biological fluids...
  50. Nalamachu S, Crockett R, Gammaitoni A, Gould E. A comparison of the lidocaine patch 5% vs naproxen 500 mg twice daily for the relief of pain associated with carpal tunnel syndrome: a 6-week, randomized, parallel-group study. MedGenMed. 2006;8:33 pubmed
    ..pilot clinical trial was designed to compare the safety and effectiveness of the lidocaine patch 5% to that of naproxen 500 mg twice daily for the treatment of neuropathic pain associated with CTS...
  51. McGettigan P, Henry D. Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. JAMA. 2006;296:1633-44 pubmed
    ..40 (95% CI, 1.16-1.70). The other drugs had summary relative risks close to 1: naproxen, 0.97 (95% CI, 0.87-1.07); piroxicam, 1.06 (95% CI, 0.70-1.59); and ibuprofen, 1.07 (95% CI, 0.97-1.18)...
  52. Bowalgaha K, Elliot D, Mackenzie P, Knights K, Swedmark S, Miners J. S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005;60:423-33 pubmed
    To characterize the kinetics of S-naproxen ('naproxen') acyl glucuronidation and desmethylnaproxen acyl and phenolic glucuronidation by human liver microsomes and identify the human UGT isoform(s) catalysing these reactions...
  53. Bjørnsson G, Haanaes H, Skoglund L. Naproxen 500 mg bid versus acetaminophen 1000 mg qid: effect on swelling and other acute postoperative events after bilateral third molar surgery. J Clin Pharmacol. 2003;43:849-58 pubmed
    ..crossover study, in which the patients acted as their own controls, was carried out to test the efficacy of naproxen 500 mg x 2 versus acetaminophen 1000 mg x 4 for 3 days on the postoperative course following third molar surgery...