simvastatin

Summary

Summary: A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.

Top Publications

  1. Zamin I, Mattos A, Mattos A, Coral G, Santos D, Rhoden C. The vitamin E reduces liver lipoperoxidation and fibrosis in a model of nonalcoholic steatohepatitis. Arq Gastroenterol. 2010;47:86-92 pubmed
    ..induced by a methionine and choline deficient diet, as well as to evaluate the role of metformin, vitamin E and simvastatin in the nonalcoholic steatohepatitis progression...
  2. Sekine Y, Demosky S, Stonik J, Furuya Y, Koike H, Suzuki K, et al. High-density lipoprotein induces proliferation and migration of human prostate androgen-independent cancer cells by an ABCA1-dependent mechanism. Mol Cancer Res. 2010;8:1284-94 pubmed publisher
    ..b>Simvastatin, which inhibited ABCA1 expression in PC-3 and DU145 cells, attenuated HDL-induced PC-3 and DU145 cell ..
  3. Forde I, Chandola T, Raine R, Marmot M, Kivimaki M. Socioeconomic and ethnic differences in use of lipid-lowering drugs after deregulation of simvastatin in the UK: the Whitehall II prospective cohort study. Atherosclerosis. 2011;215:223-8 pubmed publisher
    We examined socioeconomic and ethnic differences in use of lipid-lowering drugs after deregulation of simvastatin in the UK for adults with moderate or high risk of coronary heart disease...
  4. van der Vaart T, Plasschaert E, Rietman A, Renard M, Oostenbrink R, Vogels A, et al. Simvastatin for cognitive deficits and behavioural problems in patients with neurofibromatosis type 1 (NF1-SIMCODA): a randomised, placebo-controlled trial. Lancet Neurol. 2013;12:1076-83 pubmed publisher
    ..We aimed to assess the use of simvastatin for the improvement of cognitive and behavioural deficits in children with neurofibromatosis type 1 for 12 ..
  5. Thomas N, Holm R, Garmer M, Karlsson J, Mullertz A, Rades T. Supersaturated self-nanoemulsifying drug delivery systems (Super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug simvastatin in dogs. AAPS J. 2013;15:219-27 pubmed publisher
    ..Conventional SNEDDS contained simvastatin (SIM) at 75% of the equilibrium solubility (S (eq))...
  6. Criner G, Connett J, Aaron S, Albert R, Bailey W, Casaburi R, et al. Simvastatin for the prevention of exacerbations in moderate-to-severe COPD. N Engl J Med. 2014;370:2201-10 pubmed publisher
    ..We prospectively studied the efficacy of simvastatin in preventing exacerbations in a large, multicenter, randomized trial...
  7. Corsetti G, Pasini E, Ferrari Vivaldi M, Romano C, Bonomini F, Tasca G, et al. Metabolic syndrome and chronic simvastatin therapy enhanced human cardiomyocyte stress before and after ischemia-reperfusion in cardio-pulmonary bypass patients. Int J Immunopathol Pharmacol. 2012;25:1063-74 pubmed
    ..that cardiomyocytes from patients with MetS may be more sensitive to surgical stress, in particular after simvastatin therapy (MetS+Stat)...
  8. Oh B, Kim T, Min H, Kim M, Kang M, Huh J, et al. Synergistic killing effect of imatinib and simvastatin on imatinib-resistant chronic myelogenous leukemia cells. Anticancer Drugs. 2013;24:20-31 pubmed publisher
    The antiproliferative effect of simvastatin on tumor cells has been speculated to be by intracellular signal inhibition through 3-hydroxy-3-methylglutaryl acetyl coenzyme A reductase...
  9. Piechota Polanczyk A, Demyanets S, Nykonenko O, Huk I, Mittlboeck M, Domenig C, et al. Decreased tissue levels of cyclophilin A, a cyclosporine a target and phospho-ERK1/2 in simvastatin patients with abdominal aortic aneurysm. Eur J Vasc Endovasc Surg. 2013;45:682-8 pubmed publisher
    ..The study was performed on AAA wall-tissue samples obtained from 30 simvastatin-treated and 15 non-statin patients (2:1 case to control)...

More Information

Publications65

  1. Moutzouri E, Tellis C, Rousouli K, Liberopoulos E, Milionis H, Elisaf M, et al. Effect of simvastatin or its combination with ezetimibe on Toll-like receptor expression and lipopolysaccharide - induced cytokine production in monocytes of hypercholesterolemic patients. Atherosclerosis. 2012;225:381-7 pubmed publisher
    ..Recently, a pivotal role of TLR2 and TLR4 has been recognized in atherogenesis. We investigated the effect of simvastatin monotherapy or its combination with ezetimibe on TLR2 and TLR4 membrane expression and on lipopolysaccharide (..
  2. Belser J, Szretter K, Katz J, Tumpey T. Simvastatin and oseltamivir combination therapy does not improve the effectiveness of oseltamivir alone following highly pathogenic avian H5N1 influenza virus infection in mice. Virology. 2013;439:42-6 pubmed publisher
    ..We demonstrate that, unlike oseltamivir administration, simvastatin administration did not reduce morbidity, mortality, or viral load of mice infected with H1N1 or H5N1 viruses...
  3. Jiang S, Chen Q, Venners S, Zhong G, Hsu Y, Xing H, et al. Effect of simvastatin on plasma homocysteine levels and its modification by MTHFR C677T polymorphism in Chinese patients with primary hyperlipidemia. Cardiovasc Ther. 2013;31:e27-33 pubmed publisher
    We investigate the effect of simvastatin on plasma homocysteine (Hcy) levels and whether genetic factor affects the effect of simvastatin. A total of 338 patients with hyperlipidemia were enrolled...
  4. Jiang L, Sun H, Yuan A, Zhang K, Li D, Li C, et al. Enhancement of osteoinduction by continual simvastatin release from poly(lactic-co-glycolic acid)-hydroxyapatite-simvastatin nano-fibrous scaffold. J Biomed Nanotechnol. 2013;9:1921-8 pubmed
    b>Simvastatin is considered as a stimulator for bone formation. However, the half-life for simvastatin is generally 2 hours, which means, it is difficult to maintain biologically active simvastatin in vivo...
  5. Wang W, Zhao C, Zhou J, Zhen Z, Wang Y, Shen C. Simvastatin ameliorates liver fibrosis via mediating nitric oxide synthase in rats with non-alcoholic steatohepatitis-related liver fibrosis. PLoS ONE. 2013;8:e76538 pubmed publisher
    b>Simvastatin exerts pleiotropic effects on cardiovascular system. However, its effect on non-alcoholic fatty liver disease, especially the liver fibrosis, remains obscure...
  6. Berthold H, Seidah N, Benjannet S, Gouni Berthold I. Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels. PLoS ONE. 2013;8:e60095 pubmed publisher
    ..The purpose of this study was to investigate how ezetimibe and simvastatin, alone and in combination, affect PCSK9 circulating concentrations...
  7. Hopewell J, Parish S, Offer A, Link E, Clarke R, Lathrop M, et al. Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study. Eur Heart J. 2013;34:982-92 pubmed publisher
    ..This study of 18 705 individuals aims to identify genetic variants related to the lipid response to simvastatin and assess their impact on vascular risk response...
  8. Costa R, Fernandes M, de Souza Pinto N, Vercesi A. Protective effects of l-carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatin. Eur J Pharmacol. 2013;701:82-6 pubmed publisher
    ..Here we investigated the pathways leading to simvastatin-induced prostate cancer cell death as well as the mechanisms of cell death protection by l-carnitine or ..
  9. Parihar S, Guler R, Lang D, Suzuki H, Marais A, Brombacher F. Simvastatin enhances protection against Listeria monocytogenes infection in mice by counteracting Listeria-induced phagosomal escape. PLoS ONE. 2013;8:e75490 pubmed publisher
    ..monocytogenes infection by reducing membrane cholesterol in macrophages and thereby preventing effectivity of the cholesterol-dependent LLO-mediated phagosomal escape of bacteria. ..
  10. Zanfardino M, Spampanato C, De Cicco R, Buommino E, De Filippis A, Baiano S, et al. Simvastatin reduces melanoma progression in a murine model. Int J Oncol. 2013;43:1763-70 pubmed publisher
    ..To date, the exact mechanism of cancer cell growth arrest induced by statins is not known. We report that simvastatin is able to induce apoptosis in melanoma cells but not in normal cells and also able to contrast the growth of ..
  11. Hwang K, Park C, Kwon S, Kim Y, Park D, Lee M, et al. Synergistic induction of apoptosis by sulindac and simvastatin in A549 human lung cancer cells via reactive oxygen species-dependent mitochondrial dysfunction. Int J Oncol. 2013;43:262-70 pubmed publisher
    ..lung cancer chemoprevention through a mechanism-based approach using sulindac at low doses in combination with simvastatin. We found that sulindac-induced cytotoxicity was significantly enhanced in the presence of simvastatin...
  12. Falcone D, Gallelli L, Di Virgilio A, Tucci L, Scaramuzzino M, Terracciano R, et al. Effects of simvastatin and rosuvastatin on RAS protein, matrix metalloproteinases and NF-?B in lung cancer and in normal pulmonary tissues. Cell Prolif. 2013;46:172-82 pubmed publisher
    In this study, we have evaluated effects of 24-hour treatments with simvastatin or rosuvastatin on RAS protein, NF-?B and MMP expression in LC tissues obtained from 12 patients undergoing thoracic surgery...
  13. Liberopoulos E, Makariou S, Moutzouri E, Kostapanos M, Challa A, Elisaf M. Effect of simvastatin/ezetimibe 10/10 mg versus simvastatin 40 mg on serum vitamin D levels. J Cardiovasc Pharmacol Ther. 2013;18:229-33 pubmed publisher
    ..To investigate whether combined treatment with simvastatin/ezetimibe 10/10 mg would increase 25(OH)VitD levels compared to simvastatin 40 mg monotherapy in patients with ..
  14. Tison F, Negre Pages L, Meissner W, Dupouy S, Li Q, Thiolat M, et al. Simvastatin decreases levodopa-induced dyskinesia in monkeys, but not in a randomized, placebo-controlled, multiple cross-over ("n-of-1") exploratory trial of simvastatin against levodopa-induced dyskinesia in Parkinson's disease patients. Parkinsonism Relat Disord. 2013;19:416-21 pubmed publisher
    b>Simvastatin may improve levodopa-induced dyskinesia through striatal Ras-extracellular signal-regulated kinase pathway modulation.
  15. Moutzouri E, Liberopoulos E, Tellis C, Milionis H, Tselepis A, Elisaf M. Comparison of the effect of simvastatin versus simvastatin/ezetimibe versus rosuvastatin on markers of inflammation and oxidative stress in subjects with hypercholesterolemia. Atherosclerosis. 2013;231:8-14 pubmed publisher
    ..The aim of this study was to compare the effects of simvastatin, simvastatin/ezetimibe or rosuvastatin at equivalent low-density lipoprotein cholesterol lowering doses on ..
  16. Shunmugavel A, Martin M, Khan M, Copay A, Subach B, Schuler T, et al. Simvastatin ameliorates cauda equina compression injury in a rat model of lumbar spinal stenosis. J Neuroimmune Pharmacol. 2013;8:274-86 pubmed publisher
    ..To investigate the therapeutic efficacy of simvastatin in restoring normal locomotor function after cauda equina compression (CEC) in a rat model of LSS, CEC injury ..
  17. Reyes Soffer G, Ngai C, Lovato L, Karmally W, Ramakrishnan R, Holleran S, et al. Effect of combination therapy with fenofibrate and simvastatin on postprandial lipemia in the ACCORD lipid trial. Diabetes Care. 2013;36:422-8 pubmed publisher
    The Action to Control Cardiovascular Risk in Diabetes lipid study (ACCORD Lipid), which compared the effects of simvastatin plus fenofibrate (FENO-S) versus simvastatin plus placebo (PL-S) on cardiovascular disease outcomes, measured ..
  18. Zhu M, Wang J, Liu M, Du D, Xia C, Shen L, et al. Upregulation of protein phosphatase 2A and NR3A-pleiotropic effect of simvastatin on ischemic stroke rats. PLoS ONE. 2012;7:e51552 pubmed publisher
    ..is meaningful to uncover whether protein phosphatase 2A (PP2A) and NR3A play a role in the protective effect of Simvastatin on ischemic stroke...
  19. Fang Z, Tang Y, Fang J, Zhou Z, Xing Z, Guo Z, et al. Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway. PLoS ONE. 2013;8:e62823 pubmed publisher
    ..In the present study, we aimed to investigate the potential effects of simvastatin on RCC cells and the underlying mechanisms by which simvastatin exerted its actions...
  20. Wang W, Song W, Wang Y, Chen L, Yan X. HMG-CoA reductase inhibitors, simvastatin and atorvastatin, downregulate ABCG1-mediated cholesterol efflux in human macrophages. J Cardiovasc Pharmacol. 2013;62:90-8 pubmed publisher
    ..b>Simvastatin and atorvastatin were used in this study...
  21. Moscardo A, Valles J, LaTorre A, Madrid I, Santos M. Reduction of platelet cytosolic phospholipase A2 activity by atorvastatin and simvastatin: biochemical regulatory mechanisms. Thromb Res. 2013;131:e154-9 pubmed publisher
    ..To explore and compare the antiplatelet effect of two lipophilic statins (atorvastatin and simvastatin) and one hydrophilic statin (pravastatin) concerning: a) collagen-induced platelet aggregation and thromboxane ..
  22. Chataway J, Schuerer N, Alsanousi A, Chan D, MacManus D, Hunter K, et al. Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial. Lancet. 2014;383:2213-21 pubmed publisher
    ..b>Simvastatin, which is widely used for treatment of vascular disease, with its excellent safety profile, has ..
  23. Park Y, Seo S, Lee E, Ku J, Kim H, Kwak C. Simvastatin induces apoptosis in castrate resistant prostate cancer cells by deregulating nuclear factor-?B pathway. J Urol. 2013;189:1547-52 pubmed publisher
    In castrate resistant prostate cancer cells we investigated the cytotoxic effect of simvastatin and the mechanism involved...
  24. Larsen S, Stride N, Hey Mogensen M, Hansen C, Bang L, Bundgaard H, et al. Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance. J Am Coll Cardiol. 2013;61:44-53 pubmed publisher
    ..content, mitochondrial density, and mitochondrial oxidative phosphorylation (OXPHOS) capacity were measured in simvastatin-treated patients (n = 10) and in well-matched control subjects (n = 9)...
  25. Wu W, Wang Q, Zhang T, Mi S, Liu Y, Wang L. Gas chromatography analysis of serum cholesterol synthesis and absorption markers used to predict the efficacy of simvastatin in patients with coronary heart disease. Clin Biochem. 2013;46:993-998 pubmed publisher
    We investigated the changes in cholesterol absorption and synthesis markers before and after simvastatin therapy in Chinese patients with coronary heart disease...
  26. Zhang Z, Zhang M, Li Y, Liu S, Ping S, Wang J, et al. Simvastatin inhibits the additive activation of ERK1/2 and proliferation of rat vascular smooth muscle cells induced by combined mechanical stress and oxLDL through LOX-1 pathway. Cell Signal. 2013;25:332-40 pubmed publisher
    ..mechanical stretch stress (10% elongation) with and without oxLDL (25 ?g/ml) in the presence and absence of simvastatin (2.5 ?mol/L)...
  27. Hwang K, Kwon S, Kim Y, Park D, Kim B, Yoon K, et al. Effect of simvastatin on the resistance to EGFR tyrosine kinase inhibitors in a non-small cell lung cancer with the T790M mutation of EGFR. Exp Cell Res. 2014;323:288-96 pubmed publisher
    ..This study investigated overcoming resistance to EGFR-TKI using simvastatin. We demonstrated that addition of simvastatin to gefitinib enhanced caspase-dependent apoptosis in T790M mutant ..
  28. Hihara T, Taniguchi T, Ueda M, Yoshinaga T, Miyamoto N, Sawada K. Probucol and the cholesterol synthesis inhibitors simvastatin and triparanol regulate I ks channel function differently. Hum Exp Toxicol. 2013;32:1028-37 pubmed publisher
    ..we investigated the effects of three cholesterol-lowering agents (probucol, an enhancer of cholesterol efflux; simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor; and triparanol, a 3?-hydroxysterol-?24-reductase ..
  29. Jin R, Zhu X, Liu L, Nanda A, Granger D, Li G. Simvastatin attenuates stroke-induced splenic atrophy and lung susceptibility to spontaneous bacterial infection in mice. Stroke. 2013;44:1135-43 pubmed publisher
    ..We investigated the effects of simvastatin treatment on stroke-induced splenic atrophy and lung susceptibility to bacterial infection in acute ..
  30. Wu Z, Chen Y, Zhao S. Simvastatin inhibits ox-LDL-induced inflammatory adipokines secretion via amelioration of ER stress in 3T3-L1 adipocyte. Biochem Biophys Res Commun. 2013;432:365-9 pubmed publisher
    ..The aim of this study is to evaluate the effect of simvastatin on the ox-LDL-induced ER stress and expression and secretion of TNF-? and MCP-1 in 3T3-L1 adipocytes...
  31. Sonntag F, Schaefer J, Gitt A, Weizel A, Jannowitz C, Karmann B, et al. [Lipid therapy in daily routine]. Dtsch Med Wochenschr. 2012;137:2047-52 pubmed
    ..Treatment with simvastatin 40?mg was an inclusion criterion...
  32. Farnier M, Guyton J, Jensen E, Polis A, Johnson Levonas A, Brudi P. Effects of ezetimibe, simvastatin and ezetimibe/simvastatin on correlations between apolipoprotein B, LDL cholesterol and non-HDL cholesterol in patients with primary hypercholesterolemia. Atherosclerosis. 2013;229:415-22 pubmed publisher
    ..3 randomized clinical trials in patients with primary hypercholesterolemia receiving placebo, ezetimibe (EZE), simvastatin (SIMVA) or EZE/SIMVA for 12 weeks...
  33. Bui T, Kocher J, Li Y, Wen K, Li G, Liu F, et al. Median infectious dose of human norovirus GII.4 in gnotobiotic pigs is decreased by simvastatin treatment and increased by age. J Gen Virol. 2013;94:2005-16 pubmed publisher
    ..In this study, the effects of age and a cholesterol-lowering drug, simvastatin, on the susceptibility of pigs to NoV infection were evaluated...
  34. Tai I, Fu Y, Wang C, Chang J, Ho M. Local delivery of controlled-release simvastatin/PLGA/HAp microspheres enhances bone repair. Int J Nanomedicine. 2013;8:3895-904 pubmed publisher
    ..This study aimed to prevent this degradation by developing a locally administered formulation of simvastatin that is encapsulated in poly(lactic-co-glycolic acid)/hydroxyapatite (SIM/PLGA/HAp) microspheres with ..
  35. Pelaia G, Gallelli L, Renda T, Fratto D, Falcone D, Caraglia M, et al. Effects of statins and farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in non-small lung cancer cells. Cell Prolif. 2012;45:557-65 pubmed publisher
    ..Within such a context, the aim of our study was to investigate effects of either simvastatin (at concentrations of 1, 15, and 30 ?m) or the farnesyl transferase inhibitor R115777 (at concentrations of 0...
  36. Cerra M, Luo W, Li S, Matthews C, O Neill E, Wagner J, et al. The effects of simvastatin on the pharmacokinectics of sitagliptin. J Popul Ther Clin Pharmacol. 2012;19:e356-60 pubmed
    ..with the combination of sitagliptin (a dipeptidyl peptidase 4 inhibitor which improves glycemic control) and simvastatin (a well characterized lipid-lowering agent) may be considered an appropriate approach to management of type 2 ..
  37. Abbas A, Sakr H. Simvastatin and vitamin E effects on cardiac and hepatic oxidative stress in rats fed on high fat diet. J Physiol Biochem. 2013;69:737-50 pubmed publisher
    ..p.), control with simvastatin (SIM) (10 mg/kg of body weight/day), HFD, HFD with vitamin E, and HFD with SIM...
  38. Villanueva J, Sokalska A, Cress A, Ortega I, Bruner Tran K, Osteen K, et al. Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J Clin Endocrinol Metab. 2013;98:E455-62 pubmed publisher
    ..is inhibited by resveratrol, a natural polyphenol with antiproliferative and antiinflammatory properties, and simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) activity...
  39. Chang H, Chen C, Hsu Y, Kuo W, Ou G, Chiu P, et al. Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade. Biochim Biophys Acta. 2013;1830:4053-64 pubmed publisher
    ..In this study, we explored the underlying mechanisms in simvastatin-induced HCT116 colorectal cancer cell apoptosis...
  40. Yang T, Chen M, Sun T. Simvastatin attenuates TGF-?1-induced epithelial-mesenchymal transition in human alveolar epithelial cells. Cell Physiol Biochem. 2013;31:863-74 pubmed publisher
    ..b>Simvastatin (Sim), a 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase inhibitor, has been previously reported to inhibit ..
  41. Almassinokiani F, Mehdizadeh A, Sariri E, Rezaei M, Almasi A, Akbari H, et al. Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis. Med Sci Monit. 2013;19:534-9 pubmed publisher
    To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis.
  42. Kok S, Lin L, Hou K, Hong C, Chang C, Hsiao M, et al. Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling. Arthritis Rheum. 2013;65:639-49 pubmed publisher
    ..of cysteine-rich protein 61 (CYR-61) in rheumatoid arthritis synovial fibroblasts (RASFs) and the influence of simvastatin on this pathway, and to determine the relationship between disease progression and FoxO3a/CYR-61 signaling in ..
  43. Xu Y, Long L, Yan J, Wei L, Pan M, Gao H, et al. Simvastatin induces neuroprotection in 6-OHDA-lesioned PC12 via the PI3K/AKT/caspase 3 pathway and anti-inflammatory responses. CNS Neurosci Ther. 2013;19:170-7 pubmed publisher
    ..This study aims to investigate how simvastatin affects 6-hydroxydopamine-lesioned PC12 via regulating PI3K/AKT/caspase 3 and modulating inflammatory mediators...
  44. Nath S, Son S, Sadiasa A, Min Y, Lee B. Preparation and characterization of PLGA microspheres by the electrospraying method for delivering simvastatin for bone regeneration. Int J Pharm. 2013;443:87-94 pubmed publisher
    ..Several experiments were carried out using the PLGA-DCM source solution with different amounts of simvastatin (SIM), a drug that enhances bone regeneration, to understand this drug delivery system...
  45. Glück B, Schmidtke M, Walther M, Meerbach A, Wutzler P. Simvastatin treatment showed no prophylactic effect in influenza virus-infected mice. J Med Virol. 2013;85:1978-82 pubmed publisher
    b>Simvastatin, a cholesterol-lowering drug, is reported to have immunomodulatory properties that attenuated acute lung injury independent of their major lipid lowering effects...
  46. Krysiak R, Okopien B. Lymphocyte-suppressing and systemic anti-inflammatory effects of high-dose metformin in simvastatin-treated patients with impaired fasting glucose. Atherosclerosis. 2012;225:403-7 pubmed publisher
    ..Sixty-two subjects with impaired fasting glucose (IFG) treated for at least 3 months with simvastatin were allocated into one of two groups receiving, respectively, metformin (3 g daily) or placebo for the ..
  47. Zhang K, Meng X, Kong J, Liu F, Yang J, Gao F, et al. Simvastatin increases Prolyl-4-Hydroxylase ?1 expression in atherosclerotic plaque and ox-LDL-stimulated human aortic smooth muscle cells via p38 MAPK and ERK1/2 signaling. J Mol Cell Cardiol. 2013;65:43-50 pubmed publisher
    ..We hypothesize that simvastatin may increase the expression of P4H?1 in atherosclerotic plaques and ox-LDL-stimulated human aortic smooth ..
  48. Lawson G, Cocks E, Tanna S. Bisoprolol, ramipril and simvastatin determination in dried blood spot samples using LC-HRMS for assessing medication adherence. J Pharm Biomed Anal. 2013;81-82:99-107 pubmed publisher
    ..spectrometry (LC-HRMS) method was developed and validated for the determination of bisoprolol, ramipril and simvastatin. Whole blood spiked with target analytes was used to produce 30 ?l blood spots on specimen collection cards...
  49. Hoch M, Hoever P, Theodor R, Dingemanse J. Almorexant effects on CYP3A4 activity studied by its simultaneous and time-separated administration with simvastatin and atorvastatin. Eur J Clin Pharmacol. 2013;69:1235-45 pubmed publisher
    ..at steady-state when administered either concomitantly or 2 h after administration of single doses of simvastatin (40 mg) or atorvastatin (40 mg)...
  50. Wei Y, Li X, Xu M, Abais J, Chen Y, Riebling C, et al. Enhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes. Cell Physiol Biochem. 2013;31:925-37 pubmed publisher
    ..The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes (CAMs) to thereby exert their ..
  51. Janardhanan R, Yang B, Vohra P, Roy B, Withers S, Bhattacharya S, et al. Simvastatin reduces venous stenosis formation in a murine hemodialysis vascular access model. Kidney Int. 2013;84:338-52 pubmed publisher
    ..These cells have increased proliferative and migratory capacity leading to VNH formation. Simvastatin was used to decrease VEGF-A and MMP-9 gene expression in our murine arteriovenous fistula model created by ..
  52. Zhang S, Luo L, Wang Y, Rahman M, Lepsenyi M, Syk I, et al. Simvastatin protects against T cell immune dysfunction in abdominal sepsis. Shock. 2012;38:524-31 pubmed publisher
    ..Herein, we hypothesized that simvastatin may attenuate T-cell dysfunction in abdominal sepsis...
  53. Oka S, Matsumoto T, Kubo S, Matsushita T, Sasaki H, Nishizawa Y, et al. Local administration of low-dose simvastatin-conjugated gelatin hydrogel for tendon-bone healing in anterior cruciate ligament reconstruction. Tissue Eng Part A. 2013;19:1233-43 pubmed publisher
    ..Several reports have shown the therapeutic effects of simvastatin on bone formation with neovascularization...
  54. Muñoz M, Maxwell P, Green K, Hughes D, Talbert R. Pravastatin versus simvastatin for prevention of contrast-induced nephropathy. J Cardiovasc Pharmacol Ther. 2011;16:376-9 pubmed publisher
    ..purpose of this retrospective, single-center trial was to compare the incidence of CIN in patients receiving simvastatin or pravastatin therapy undergoing percutaneous coronary intervention (PCI)...
  55. Murtola T, Syvälä H, Pennanen P, Bläuer M, Solakivi T, Ylikomi T, et al. Comparative effects of high and low-dose simvastatin on prostate epithelial cells: the role of LDL. Eur J Pharmacol. 2011;673:96-100 pubmed publisher
    ..We compared responses to high-dose and therapeutic-dose simvastatin in normal and cancerous prostate epithelial cells...
  56. Esposito E, Rinaldi B, Mazzon E, Donniacuo M, Impellizzeri D, Paterniti I, et al. Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-?. J Neuroinflammation. 2012;9:81 pubmed publisher
    Statins such as simvastatin are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase used in the prevention of cardiovascular disease...