lovastatin

Summary

Summary: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.

Top Publications

  1. Jia Z, Zhang X, Zhao Y, Cao X. Enhancement of lovastatin production by supplementing polyketide antibiotics to the submerged culture of Aspergillus terreus. Appl Biochem Biotechnol. 2010;160:2014-25 pubmed publisher
    Feedback inhibition existed in lovastatin biosynthesis from Aspergillus terreus. Exogenous lovastatin and other different polyketide antibiotics biosynthesized by polyketide synthase were supplemented to the cultures of A...
  2. Ma F, Chen F, Ren Q, Han Z. Lovastatin restores the function of endothelial progenitor cells damaged by oxLDL. Acta Pharmacol Sin. 2009;30:545-52 pubmed publisher
    The aim of the study was to investigate whether lovastatin restores the survival and function of endothelial progenitor cells (EPCs) damaged by oxLDL...
  3. Kato S, Smalley S, Sadarangani A, Chen Lin K, Oliva B, Brañes J, et al. Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. J Cell Mol Med. 2010;14:1180-93 pubmed publisher
    ..The apoptotic potential of two lipophilic statins (lovastatin and simvastatin) and one hydrophilic statin (pravastatin) was assessed in cancer cell lines (ovarian, ..
  4. Shen J, Wang L, Zheng L, Zhu J, Hu S. Lovastatin inhibits gap junctional communication in cultured aortic smooth muscle cells. J Cardiovasc Pharmacol Ther. 2010;15:296-302 pubmed publisher
    ..We hypothesized in this study that lovastatin inhibits vascular smooth muscle cells (VSMCs) migration through the inhibition of the GJIC...
  5. Tilahun M, Kwan A, Natarajan K, Quinn M, Tilahun A, Xie C, et al. Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB. PLoS ONE. 2011;6:e27203 pubmed publisher
    ..Similarly, in vivo, lovastatin alone conferred only partial protection from TSS similar to single anti-SEB antibodies...
  6. Mattioli E, Columbaro M, Capanni C, Maraldi N, Cenni V, Scotlandi K, et al. Prelamin A-mediated recruitment of SUN1 to the nuclear envelope directs nuclear positioning in human muscle. Cell Death Differ. 2011;18:1305-15 pubmed publisher
    ..These results demonstrate that the interplay between SUN1 and farnesylated prelamin A contributes to nuclear positioning in human myofibers and may be implicated in pathogenetic mechanisms. ..
  7. Wang C, Shui H, Chang T. In vivo evidence of duality effects for lovastatin in a nude mouse cancer model. Int J Cancer. 2010;126:578-82 pubmed publisher
    ..nude mouse model in which cancer cells were seeded subcutaneously to examine the potential anticancer effects of lovastatin in vivo...
  8. Björkhem Bergman L, Acimovic J, Torndal U, Parini P, Eriksson L. Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation. Anticancer Res. 2010;30:1105-12 pubmed
    ..The effects of lovastatin, with and without addition of ubiquinone, were studied in a rat model for chemically induced ..
  9. Shrivastava S, Pucadyil T, Paila Y, Ganguly S, Chattopadhyay A. Chronic cholesterol depletion using statin impairs the function and dynamics of human serotonin(1A) receptors. Biochemistry. 2010;49:5426-35 pubmed publisher
    ..Our results assume significance in view of recent reports highlighting the symptoms of anxiety and depression in humans upon statin administration, and the role of serotonin(1A) receptors in anxiety and depression. ..
  10. Huelsenbeck J, Henninger C, Schad A, Lackner K, Kaina B, Fritz G. Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity. Cell Death Dis. 2011;2:e190 pubmed publisher
    ..Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro...

Detail Information

Publications84

  1. Jia Z, Zhang X, Zhao Y, Cao X. Enhancement of lovastatin production by supplementing polyketide antibiotics to the submerged culture of Aspergillus terreus. Appl Biochem Biotechnol. 2010;160:2014-25 pubmed publisher
    Feedback inhibition existed in lovastatin biosynthesis from Aspergillus terreus. Exogenous lovastatin and other different polyketide antibiotics biosynthesized by polyketide synthase were supplemented to the cultures of A...
  2. Ma F, Chen F, Ren Q, Han Z. Lovastatin restores the function of endothelial progenitor cells damaged by oxLDL. Acta Pharmacol Sin. 2009;30:545-52 pubmed publisher
    The aim of the study was to investigate whether lovastatin restores the survival and function of endothelial progenitor cells (EPCs) damaged by oxLDL...
  3. Kato S, Smalley S, Sadarangani A, Chen Lin K, Oliva B, Brañes J, et al. Lipophilic but not hydrophilic statins selectively induce cell death in gynaecological cancers expressing high levels of HMGCoA reductase. J Cell Mol Med. 2010;14:1180-93 pubmed publisher
    ..The apoptotic potential of two lipophilic statins (lovastatin and simvastatin) and one hydrophilic statin (pravastatin) was assessed in cancer cell lines (ovarian, ..
  4. Shen J, Wang L, Zheng L, Zhu J, Hu S. Lovastatin inhibits gap junctional communication in cultured aortic smooth muscle cells. J Cardiovasc Pharmacol Ther. 2010;15:296-302 pubmed publisher
    ..We hypothesized in this study that lovastatin inhibits vascular smooth muscle cells (VSMCs) migration through the inhibition of the GJIC...
  5. Tilahun M, Kwan A, Natarajan K, Quinn M, Tilahun A, Xie C, et al. Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB. PLoS ONE. 2011;6:e27203 pubmed publisher
    ..Similarly, in vivo, lovastatin alone conferred only partial protection from TSS similar to single anti-SEB antibodies...
  6. Mattioli E, Columbaro M, Capanni C, Maraldi N, Cenni V, Scotlandi K, et al. Prelamin A-mediated recruitment of SUN1 to the nuclear envelope directs nuclear positioning in human muscle. Cell Death Differ. 2011;18:1305-15 pubmed publisher
    ..These results demonstrate that the interplay between SUN1 and farnesylated prelamin A contributes to nuclear positioning in human myofibers and may be implicated in pathogenetic mechanisms. ..
  7. Wang C, Shui H, Chang T. In vivo evidence of duality effects for lovastatin in a nude mouse cancer model. Int J Cancer. 2010;126:578-82 pubmed publisher
    ..nude mouse model in which cancer cells were seeded subcutaneously to examine the potential anticancer effects of lovastatin in vivo...
  8. Björkhem Bergman L, Acimovic J, Torndal U, Parini P, Eriksson L. Lovastatin prevents carcinogenesis in a rat model for liver cancer. Effects of ubiquinone supplementation. Anticancer Res. 2010;30:1105-12 pubmed
    ..The effects of lovastatin, with and without addition of ubiquinone, were studied in a rat model for chemically induced ..
  9. Shrivastava S, Pucadyil T, Paila Y, Ganguly S, Chattopadhyay A. Chronic cholesterol depletion using statin impairs the function and dynamics of human serotonin(1A) receptors. Biochemistry. 2010;49:5426-35 pubmed publisher
    ..Our results assume significance in view of recent reports highlighting the symptoms of anxiety and depression in humans upon statin administration, and the role of serotonin(1A) receptors in anxiety and depression. ..
  10. Huelsenbeck J, Henninger C, Schad A, Lackner K, Kaina B, Fritz G. Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity. Cell Death Dis. 2011;2:e190 pubmed publisher
    ..Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro...
  11. Sharaf El Din M, Attia K, Nassar M, Kaddah M. Colorimetric determination of simvastatin and lovastatin in pure form and in pharmaceutical formulations. Spectrochim Acta A Mol Biomol Spectrosc. 2010;76:423-8 pubmed publisher
    Simple, accurate and precise colorimetric method for the determination of simvastatin and lovastatin in tablets is described...
  12. Xiao Y, Li Y, Han J, Pan Y, Tie L, Li X. Transgelin 2 participates in lovastatin-induced anti-angiogenic effects in endothelial cells through a phosphorylated myosin light chain-related mechanism. PLoS ONE. 2012;7:e46510 pubmed publisher
    ..We aimed to identify new targets underlying this pleiotropic effect of lovastatin. We investigated the inhibitory effects of lovastatin on endothelial cell biology and angiogenesis in vitro...
  13. Sane K, Mynderse M, LaLonde D, Dean I, Wojtkowiak J, Fouad F, et al. A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells. J Pharmacol Exp Ther. 2010;333:23-33 pubmed publisher
    ..4-chlorobutyl(methyl)phosphoramidate], which in combination with lovastatin inhibits geranylgeranyl transferase I (GGTase I) and GGTase II/RabGGTase, without affecting farnesylation...
  14. Goyal U, Arora R, Aggarwal G. Formulation design and evaluation of a self-microemulsifying drug delivery system of lovastatin. Acta Pharm. 2012;62:357-70 pubmed publisher
    Self-microemulsifying drug delivery system (SMEDDS) of lovastatin was aimed at overcoming the problems of poor solubility and bioavailability...
  15. Martirosyan A, Clendening J, Goard C, Penn L. Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance. BMC Cancer. 2010;10:103 pubmed publisher
    ..The effect of lovastatin on ovarian cancer cell lines was evaluated alone and in combination with cisplatin and doxorubicin using several ..
  16. Elkind M, Sacco R, MacArthur R, Peerschke E, Neils G, Andrews H, et al. High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART). Cerebrovasc Dis. 2009;28:266-75 pubmed publisher
    ..We sought to determine whether lovastatin at doses above those currently approved can be administered safely within 24 h after an acute ischemic stroke...
  17. Niknejad N, Gorn Hondermann I, Ma L, Zahr S, Johnson Obeseki S, Corsten M, et al. Lovastatin-induced apoptosis is mediated by activating transcription factor 3 and enhanced in combination with salubrinal. Int J Cancer. 2014;134:268-79 pubmed publisher
    We have previously demonstrated the ability of lovastatin, a potent inhibitor of mevalonate synthesis, to induce tumor-specific apoptosis...
  18. Zhong W, Hsu S, Ho P, Liang Y, Chang T, Lee W. Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway. Biochem Pharmacol. 2011;82:1663-72 pubmed publisher
    Previously, we demonstrated that lovastatin, a HMG-CoA reductase inhibitor, induced apoptosis, differentiation, and inhibition of invasiveness of human anaplastic thyroid carcinoma cells (ATCs)...
  19. Robinson A, Kashanin D, O Dowd F, Fitzgerald K, Williams V, Walsh G. Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions. Clin Exp Allergy. 2009;39:1866-74 pubmed publisher
    ..Images were recorded in real-time at 1 min intervals and analysed using Ducocell software. Fluvastatin and lovastatin (both 10 nm) significantly inhibited GM-CSF-stimulated eosinophil adhesion to rhICAM-1 after 2 min (34.4+/-3...
  20. Ochoa L, Igartua M, Hernandez R, Gascon A, Solinis M, Pedraz J. Novel extended-release formulation of lovastatin by one-step melt granulation: in vitro and in vivo evaluation. Eur J Pharm Biopharm. 2011;77:306-12 pubmed publisher
    ..of this study was to apply a one-step melt granulation method to develop an extended-release formulation of lovastatin (LOV-ER). We prepared a formulation using PEG 6000 as binder agent in a laboratory scale high-shear mixer...
  21. Li J, Wang J, Chen D, Mott R, Yu Q, Ma J, et al. Systemic administration of HMG-CoA reductase inhibitor protects the blood-retinal barrier and ameliorates retinal inflammation in type 2 diabetes. Exp Eye Res. 2009;89:71-8 pubmed publisher
    ..In the present study we have investigated the effect of lovastatin on blood-retinal barrier and inflammatory status in the retina of db/db mice and in cultured retinal cells...
  22. Guo W, Ji H, Yan Z, Li L, Li D, Lu C. Lovastatin changes activities of lactate dehydrogenase A and B genes in rat myocardial cells. Chin Med J (Engl). 2011;124:423-8 pubmed
    Lactate dehydrogenase (LDH) is a crucial regulator of energy metabolism in many organs including the heart. Lovastatin is widely used in prevention and treatment of coronary heart disease and is a drug with substantial metabolic ..
  23. Von Zee C, Richards M, Bu P, Perlman J, Stubbs E. Increased RhoA and RhoB protein accumulation in cultured human trabecular meshwork cells by lovastatin. Invest Ophthalmol Vis Sci. 2009;50:2816-23 pubmed publisher
    This study aimed to determine the effect of lovastatin on Rho G-protein expression and activation in human trabecular meshwork (TM) cells...
  24. Barriuso J, Nguyen D, Li J, Roberts J, Macnevin G, Chaytor J, et al. Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA. J Am Chem Soc. 2011;133:8078-81 pubmed publisher
    b>Lovastatin, a cyclic nonaketide from Aspergillus terreus, is a hypercholesterolemic agent and a precursor to simvastatin, a semi-synthetic cholesterol-lowering drug...
  25. Paintlia A, Paintlia M, Singh A, Orak J, Singh I. Activation of PPAR-? and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells. Glia. 2010;58:1669-85 pubmed publisher
    Previously, we and others documented that statins including-lovastatin (LOV) promote the differentiation of oligodendrocyte progenitor cells (OPCs) and remyelination in experimental autoimmune encephalomyelitis (EAE), an multiple ..
  26. Hong M, Seeram N, Zhang Y, Heber D. Chinese red yeast rice versus lovastatin effects on prostate cancer cells with and without androgen receptor overexpression. J Med Food. 2008;11:657-66 pubmed publisher
    ..Monacolin K (MK) is identical to lovastatin (LV)...
  27. Chen C, Yang J, Uang Y, Lin C. Improved dissolution rate and oral bioavailability of lovastatin in red yeast rice products. Int J Pharm. 2013;444:18-24 pubmed publisher
    b>Lovastatin, categorized as a class II compound according to the Biopharmaceutics Classification System, is mainly responsible for the blood cholesterol lowering effect of red yeast rice (RYR)...
  28. Mihăilă R, Nedelcu L, Fratila O, Rezi E, Domnariu C, Ciucă R, et al. Lovastatin and fluvastatin reduce viremia and the pro-inflammatory cytokines in the patients with chronic hepatitis C. Hepatogastroenterology. 2009;56:1704-9 pubmed
    ..The patients were treated with fluvastatin 40 mg/day or lovastatin 20 mg/day for 28 days...
  29. Kim K, Kang J, Kim D, Park S, Park S, Kim D, et al. Generation of human chiral metabolites of simvastatin and lovastatin by bacterial CYP102A1 mutants. Drug Metab Dispos. 2011;39:140-50 pubmed publisher
    ..Simvastatin and lovastatin, which are used to treat hyperlipidemia and hypercholesterolemia, are oxidized by human CYP3A4/5 to produce ..
  30. Chung J, Yang S, Choi J. Effects of lovastatin on the pharmacokinetics of nicardipine in rats. Biopharm Drug Dispos. 2010;31:436-41 pubmed publisher
    It has been reported that both nicardipine and lovastatin are substrates of both the cytochrome P450 (CYP) 3A subfamily and P-glycoprotein (P-gp), and P-gp transport is unlikely to be a significant factor...
  31. Campbell C, Vederas J. Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes. Biopolymers. 2010;93:755-63 pubmed publisher
    The fungal polyketide lovastatin is a cholesterol lowering agent that is an immediate precursor to a multi-billion dollar drug, simvastatin (Zocor)...
  32. Osterweil E, Chuang S, Chubykin A, Sidorov M, Bianchi R, Wong R, et al. Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome. Neuron. 2013;77:243-50 pubmed publisher
    ..We discovered that lovastatin, a drug that is widely prescribed for the treatment of high cholesterol, can correct excess hippocampal protein ..
  33. Paintlia A, Paintlia M, Singh I, Singh A. Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis. Exp Neurol. 2008;214:168-80 pubmed publisher
  34. Mohan K, Muller J, Atreya C. Defective rotavirus particle assembly in lovastatin-treated MA104 cells. Arch Virol. 2008;153:2283-90 pubmed publisher
    ..The present study analyzes the effects of lovastatin, an inhibitor of cholesterol biosynthesis, during rotavirus infection in MA104 cells with regard to viral growth ..
  35. Koob A, Ubhi K, Paulsson J, Kelly J, Rockenstein E, Mante M, et al. Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies. Exp Neurol. 2010;221:267-74 pubmed publisher
    ..In this context, this study sought to investigate the in vivo effects of the cholesterol synthesis inhibitor lovastatin on alpha-syn aggregation in two different transgenic (Tg) mouse models that neuronally overexpress human alpha-..
  36. Montoya C, Jaimes F, Higuita E, Convers Páez S, Estrada S, Gutierrez F, et al. Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. Trials. 2009;10:41 pubmed publisher
    ..The interventions will be lovastatin (40 mg/day, orally, for 12 months; 55 patients) or placebo (55 patients)...
  37. Planagumà A, Pfeffer M, Rubin G, Croze R, Uddin M, Serhan C, et al. Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. Mucosal Immunol. 2010;3:270-9 pubmed publisher
    ..In this study lovastatin triggered biosynthesis of the anti-inflammatory and pro-resolving mediator 15-epi-lipoxin A(4) (15-epi-LXA(4))...
  38. Li J, Wang J, Yu Q, Chen K, Mahadev K, Zhang S. Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: role of NADPH oxidase 4. Diabetes. 2010;59:1528-38 pubmed publisher
    Oxidative stress is a key pathogenic factor in diabetic retinopathy. We previously showed that lovastatin mitigates blood-retinal barrier (BRB) breakdown in db/db mice...
  39. Horiuchi A, Kikuchi N, Osada R, Wang C, Hayashi A, Nikaido T, et al. Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer. Cancer Sci. 2008;99:2532-9 pubmed publisher
    ..exoenzyme), Rho kinase inhibitor (Y27632) and hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (Lovastatin and Pravastatin) were studied in vitro and in vivo...
  40. Henninger C, Huelsenbeck J, Huelsenbeck S, Grosch S, Schad A, Lackner K, et al. The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity. Toxicol Appl Pharmacol. 2012;261:66-73 pubmed
    ..Here, we investigated the usefulness of lovastatin, which is nowadays widely used for lipid lowering purpose, as a hepatoprotective drug following the ..
  41. Cheng S, Lai J, Yang S, Tsao T, Ho L, Liou J, et al. Modulation of human T cells signaling transduction by lovastatin. Int J Cardiol. 2010;140:24-33 pubmed publisher
    ..To gain insight into the mechanism of statins on human T cells, we investigated the effects of both lovastatin and atorvastatin on activated human primary T cells...
  42. Michalik M, Soczek E, Kosińska M, Rak M, Wójcik K, Lasota S, et al. Lovastatin-induced decrease of intracellular cholesterol level attenuates fibroblast-to-myofibroblast transition in bronchial fibroblasts derived from asthmatic patients. Eur J Pharmacol. 2013;704:23-32 pubmed publisher
    ..remodelling of the airways and statins have tentative anti-asthmatic activity, we have studied the effect of lovastatin on FMT in populations of human bronchial fibroblasts derived from asthmatic patients...
  43. Kang S, Kim E, Moon A. Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras. Oncol Rep. 2009;21:1317-22 pubmed
    ..Treatment of H-Ras MCF10A cells with simvastatin and lovastatin markedly decreased isoprenylated H-Ras in membrane fraction while the unprenylated H-Ras was increased in ..
  44. Liu Y, Zeng B, Shang H, Cen Y, Wei H. Bama miniature pigs (Sus scrofa domestica) as a model for drug evaluation for humans: comparison of in vitro metabolism and in vivo pharmacokinetics of lovastatin. Comp Med. 2008;58:580-7 pubmed
    ..To this end, in vitro lovastatin metabolism at the minipig liver microsomal level and in vivo pharmacokinetics were studied...
  45. Patel M, Tekade A, Gattani S, Surana S. Solubility enhancement of lovastatin by modified locust bean gum using solid dispersion techniques. AAPS PharmSciTech. 2008;9:1262-9 pubmed publisher
    The aim of the present study was to improve the solubility of poorly water soluble drug lovastatin (LS) by solid dispersion (SD) techniques using modified locust bean gum (MLBG) as a carrier...
  46. Shui H, Hsia C, Chen H, Chang T, Wang C. Proteomics and bioinformatics analysis of lovastatin-induced differentiation in ARO cells. J Proteomics. 2012;75:1170-80 pubmed publisher
    b>Lovastatin (lova), a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, can induce differentiation in cancer cells at low concentration, thus having potential to be used as an auxiliary agent in cancer therapy...
  47. Procino G, Barbieri C, Carmosino M, Rizzo F, Valenti G, Svelto M. Lovastatin-induced cholesterol depletion affects both apical sorting and endocytosis of aquaporin-2 in renal cells. Am J Physiol Renal Physiol. 2010;298:F266-78 pubmed publisher
    ..An internalization assay showed that AQP2 endocytosis was clearly reduced under this experimental condition. Taken together, these data suggest that association with membrane rafts may regulate both AQP2 apical sorting and endocytosis...
  48. Wagner R, Martin K, Powell R, Rzucidlo E. Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR. Am J Physiol Cell Physiol. 2010;299:C119-27 pubmed publisher
    ..We investigated the effects of lovastatin on vascular smooth muscle phenotype...
  49. Marcuzzi A, Zanin V, Piscianz E, Tricarico P, Vuch J, Girardelli M, et al. Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line. Int J Dev Neurosci. 2012;30:451-6 pubmed publisher
    ..the apoptotic mechanism mediated by the exposure of the cultured neuroblastoma cell line, SH-SY5Y, to lovastatin in absence or in presence of the isoprenoid, geranylgeraniol, with the aim of unraveling the pathogenesis of MA...
  50. Deng Y, Chang J, Yeh C, Cheng S, Kuo M. Arecoline stimulated Cyr61 production in human gingival epithelial cells: inhibition by lovastatin. Oral Oncol. 2011;47:256-61 pubmed publisher
    ..b>Lovastatin also completely inhibited arecoline-induced Cyr61 synthesis and the inhibition is dose-dependent...
  51. Klawitter J, Shokati T, Moll V, Christians U, Klawitter J. Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. Breast Cancer Res. 2010;12:R16 pubmed publisher
    ..In this study we evaluated the effects of lovastatin acid and lactone on breast cancer MDAMB231 and MDAMB468 cells using a combination of proteomic and metabonomic ..
  52. Gouveia T, Scorza F, Silva M, Bandeira T, Perosa S, Arganãraz G, et al. Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus. Epilepsy Behav. 2011;20:1-5 pubmed publisher
    ..In this context, the study described here aimed to investigate the effect of lovastatin on body temperature and on mRNA expression levels of hippocampal cytokines such as interleukin-1?, interleukin-6,..
  53. Nezami N, Safa J, Eftekhar Sadat A, Salari B, Ghorashi S, Sakhaee K, et al. Lovastatin raises serum osteoprotegerin level in people with type 2 diabetic nephropathy. Clin Biochem. 2010;43:1294-9 pubmed publisher
    ..T2DN), and anti-atherosclerotic effects of statins, the present study aimed to investigate the effects of lovastatin on serum levels of OPG and soluble receptor activator of nuclear factor-?B ligand (sRANKL) in people with T2DN...
  54. Liu H, Liang S, Kumar S, Weyman C, Liu W, Zhou A. Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression. Cancer Chemother Pharmacol. 2009;63:997-1005 pubmed publisher
    ..Ovarian cancer cells were treated with lovastatin and atorvastatin. Apoptosis in these cells and tumor formation in soft agar were determined...
  55. Dvoracek L, Kreisberg J, McKinney J, Schmid G, Francis A, Kacmarik K, et al. Lovastatin inhibits oxidized L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC)-stimulated interleukin-8 mRNA and protein synthesis in human aortic endothelial cells by depleting stores of geranylgeranyl pyrophosphate. Atherosclerosis. 2010;208:50-5 pubmed publisher
    ..Mevalonate (200 microM) reversed the inhibition of ox-PAPC-stimulated mRNA and protein levels by lovastatin, indicating the inhibitory effect of lovastatin was due to inhibition of mevalonate synthesis...
  56. Chiba Y, Sato S, Misawa M. Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice. J Smooth Muscle Res. 2008;44:123-8 pubmed
    ..a characteristic feature of allergic bronchial asthma, the effect of systemic treatment with lovastatin on antigen-induced bronchial smooth muscle hyperresponsiveness was investigated in mice...
  57. Park I, Kim J, Jung J, Han J. Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations. Invest New Drugs. 2010;28:791-9 pubmed publisher
    b>Lovastatin is a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. Its inhibitory action on HMG-CoA reductase leads to depletion of isoprenoids, which inhibits post-translational modification of RAS...
  58. Suzuki N, Imai A. HMG-CoA reductase inhibitor lovastatin causes reversible cytoskeleton perturbation by RhoA signalling suppression in peritoneal cell line Met5A. J Obstet Gynaecol. 2010;30:404-7 pubmed publisher
    ..This study investigated whether lovastatin perturbs cytoskeletons and cell morphology by RhoA suppression in peritoneal Met5A cells...
  59. Groebe K, Hayess K, Klemm Manns M, Schwall G, Wozny W, Steemans M, et al. Unexpected common mechanistic pathways for embryotoxicity of warfarin and lovastatin. Reprod Toxicol. 2010;30:121-30 pubmed publisher
    ..Using the examples of warfarin and lovastatin, two substances with entirely different primary targets, the surrogate marker signature nevertheless indicates a ..
  60. Savas S, Azorsa D, Jarjanazi H, Ibrahim Zada I, Gonzales I, Arora S, et al. NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells. PLoS ONE. 2011;6:e18306 pubmed publisher
    Simvastatin and lovastatin are statins traditionally used for lowering serum cholesterol levels. However, there exists evidence indicating their potential chemotherapeutic characteristics in cancer...
  61. Bartosik Psujek H, Tabarkiewicz J, Pocinska K, Radej S, Stelmasiak Z, Rolinski J. Immunomodulatory effects of IFN-beta and lovastatin on immunophenotype of monocyte-derived dendritic cells in multiple sclerosis. Arch Immunol Ther Exp (Warsz). 2010;58:313-9 pubmed publisher
    ..In order to evaluate their role in MS, we analyzed the in vitro effects of interferon (IFN)-beta and lovastatin on the differentiation and maturation of monocyte-derived dendritic cells (DCs) of MS patients...
  62. Singh S, Verma P, Razdan B. Development and characterization of a lovastatin-loaded self-microemulsifying drug delivery system. Pharm Dev Technol. 2010;15:469-83 pubmed publisher
    ..to develop, optimize and evaluate a self-microemulsifying drug delivery system of the poorly water soluble drug, lovastatin. Solubility of lovastatin was determined in various vehicles...
  63. Acosta M, Kardel P, Walsh K, Rosenbaum K, Gioia G, Packer R. Lovastatin as treatment for neurocognitive deficits in neurofibromatosis type 1: phase I study. Pediatr Neurol. 2011;45:241-5 pubmed publisher
    In a neurofibromatosis type 1 murine model, treatment with lovastatin reversed cognitive disabilities. We report on a phase I study examining the safety and tolerability of lovastatin in children with neurofibromatosis type 1...
  64. Dong X, Xiao Y, Jiang X, Wang Y. Quantitative proteomic analysis revealed lovastatin-induced perturbation of cellular pathways in HL-60 cells. J Proteome Res. 2011;10:5463-71 pubmed publisher
    b>Lovastatin, a member of the statin family of drugs, is widely prescribed for treating hypercholesterolemia. The statin family of drugs, however, also shows promise for cancer treatment and prevention...
  65. Renshaw P, Parsegian A, Yang C, Novero A, Yoon S, Lyoo I, et al. Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats. Pharmacol Biochem Behav. 2009;92:88-92 pubmed publisher
    ..We examined interactions between a statin (lovastatin) and a selective serotonin reuptake inhibitor (fluoxetine) using the forced swim test (FST) in rats, a ..
  66. Shivanna M, Jalimarada S, Srinivas S. Lovastatin inhibits the thrombin-induced loss of barrier integrity in bovine corneal endothelium. J Ocul Pharmacol Ther. 2010;26:1-10 pubmed publisher
    ..This study has investigated the efficacy of statins, which inhibit activation of RhoA, in opposing the thrombin-induced loss of barrier integrity of monolayers of cultured bovine corneal endothelium...
  67. Guruswamy S, Rao C. Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention. Int J Oncol. 2009;35:1037-43 pubmed
    ..We aimed to identify critical molecules and signal pathways modulated by a combination of lovastatin and celecoxib in the human HCT-116 colon cancer cell line...
  68. Mihaila R, Nedelcu L, Fratila O, Rezi E, Domnariu C, Deac M. Effects of lovastatin and pentoxyphyllin in nonalcoholic steatohepatitis. Hepatogastroenterology. 2009;56:1117-21 pubmed
    ..The present study intended to make a multicentric prospective study about the efficiency of lovastatin and pentoxyphyllin administered in patients with nonalcoholic steatohepatitis...
  69. Gao J, Zhang D, Yang X, Zhang Y, Li P, Su X. Lysophosphatidic acid and lovastatin might protect kidney in renal I/R injury by downregulating MCP-1 in rat. Ren Fail. 2011;33:805-10 pubmed publisher
    ..The aim of our study is to explore the role of lysophosphatidic acid (LPA) and lovastatin on renal I/R injury and its mechanism in the rat...
  70. Keskitalo J, Kurkinen K, Neuvonen M, Backman J, Neuvonen P, Niemi M. No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin. Br J Clin Pharmacol. 2009;68:207-13 pubmed publisher
    This study aimed to investigate possible effects of ABCB1 genotype on fluvastatin, pravastatin, lovastatin, and rosuvastatin pharmacokinetics. In a fixed-order crossover study, 10 healthy volunteers with the ABCB1 c.1236C/C-c.2677G/G-c...
  71. Kendrick J, Shlipak M, Targher G, Cook T, Lindenfeld J, Chonchol M. Effect of lovastatin on primary prevention of cardiovascular events in mild CKD and kidney function loss: a post hoc analysis of the Air Force/Texas Coronary Atherosclerosis Prevention Study. Am J Kidney Dis. 2010;55:42-9 pubmed publisher
    ..placebo-controlled trial of 5,608 men and 997 women without CVD randomly assigned to treatment with lovastatin or placebo. Placebo or lovastatin, 20 mg/d...
  72. Shi Y, Felley Bosco E, Marti T, Stahel R. Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. PLoS ONE. 2012;7:e45354 pubmed publisher
    ..b>Lovastatin was identified from the screen...
  73. Zhao T, Trinh D, Addison C, Dimitroulakos J. Lovastatin inhibits VEGFR and AKT activation: synergistic cytotoxicity in combination with VEGFR inhibitors. PLoS ONE. 2010;5:e12563 pubmed publisher
    In a recent study, we demonstrated the ability of lovastatin, a potent inhibitor of mevalonate synthesis, to inhibit the function of the epidermal growth factor receptor (EGFR)...
  74. Ye F, Zhang G, Guan B, Xu X. Suppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatin. World J Gastroenterol. 2012;18:126-35 pubmed publisher
    To determine the effects of curcumin, (-)-epigallocatechin-3-gallate (EGCG), lovastatin, and their combinations on inhibition of esophageal cancer...
  75. Whitehorn J, Van Vinh Chau N, Truong N, Tai L, Van Hao N, Hien T, et al. Lovastatin for adult patients with dengue: protocol for a randomised controlled trial. Trials. 2012;13:203 pubmed publisher
    ..These include anti-inflammatory effects at the endothelium. In addition, it is possible that lovastatin may have an anti-viral effect against dengue...
  76. Kim Y, Park K, Kang W. Effect of fluvastatin, lovastatin, nifedipine and verapamil on the systemic exposure of nateglinide in rabbits. Biopharm Drug Dispos. 2010;31:443-9 pubmed publisher
    ..of nateglinide were investigated in the presence and absence of HMG-CoA reductase inhibitors (fluvastatin, lovastatin) and calcium channel blockers (verapamil, nifedipine) in rabbits...
  77. Araujo N, Mattos A, Sarvel A, Coelho P, Katz N. Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni. Mem Inst Oswaldo Cruz. 2008;103:450-4 pubmed
    The activity of lovastatin associated with oxamniquine or praziquantel against schistosomiasis mansoni was evaluated in mice infected with Schistosoma mansoni...
  78. Asakura K, Izumi Y, Yamamoto M, Yamauchi Y, Kawai K, Serizawa A, et al. The cytostatic effects of lovastatin on ACC-MESO-1 cells. J Surg Res. 2011;170:e197-209 pubmed publisher
    ..effect of statins on malignant mesothelioma are still few, the present study was done to evaluate the effects of lovastatin on ACC-MESO-1 cells in vivo and to investigate the potential mechanisms involved in vitro...
  79. Chung Y, Cho S, Ryou H, Jee H, Choi J, Yoon K, et al. Is there a treatment advantage when paclitaxel and lovastatin are combined to dose anaplastic thyroid carcinoma cell lines?. Thyroid. 2011;21:735-44 pubmed publisher
    ..The purpose of this study was to evaluate the combined cytotoxic effects of paclitaxel and lovastatin in ATC cell lines...
  80. Chiba Y, Sato S, Misawa M. Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice. Inflamm Res. 2009;58:363-9 pubmed publisher
    ..To determine the beneficial effects of statins on allergic bronchial asthma, the effect of systemic treatment with lovastatin on antigen-induced airway inflammation was investigated.
  81. Martinez Gutierrez M, Castellanos J, Gallego Gomez J. Statins reduce dengue virus production via decreased virion assembly. Intervirology. 2011;54:202-16 pubmed publisher
    ..This study evaluated the potential antiviral activity of lovastatin (LOV) against dengue virus (DENV) infection of epithelial and endothelial cells (VERO cells, epithelial cells ..
  82. Wang W, Nyman J, Moss H, Gutierrez G, Mundy G, Yang X, et al. Local low-dose lovastatin delivery improves the bone-healing defect caused by Nf1 loss of function in osteoblasts. J Bone Miner Res. 2010;25:1658-67 pubmed publisher
    ..point of view, this defect of callus maturation and strength could be ameliorated by local delivery of low-dose lovastatin microparticles, which successfully decreased osteoid volume and cartilaginous remnant number and increased ..