oxytetracycline

Summary

Summary: A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.

Top Publications

  1. Li D, Yang M, Hu J, Ren L, Zhang Y, Li K. Determination and fate of oxytetracycline and related compounds in oxytetracycline production wastewater and the receiving river. Environ Toxicol Chem. 2008;27:80-6 pubmed
    This study investigated the occurrence and fate of oxytetracycline (OTC) and its related substances, 4-epi-oxytetracycline (EOTC), alpha-apo-oxytetracycline (alpha-apo-OTC), and beta-apo-oxytetracycline (beta-apo-OTC), in a wastewater ..
  2. Petkovic H, Cullum J, Hranueli D, Hunter I, Perić Concha N, Pigac J, et al. Genetics of Streptomyces rimosus, the oxytetracycline producer. Microbiol Mol Biol Rev. 2006;70:704-28 pubmed
    ..Streptomyces rimosus is arguably the best-characterized industrial streptomycete as the producer of oxytetracycline and other tetracycline antibiotics...
  3. Wen X, Jia Y, Li J. Degradation of tetracycline and oxytetracycline by crude lignin peroxidase prepared from Phanerochaete chrysosporium--a white rot fungus. Chemosphere. 2009;75:1003-7 pubmed publisher
    ..This study chose tetracycline (TC) and oxytetracycline (OTC) as examples of pharmaceuticals...
  4. Reynaldi F, Lacunza J, Alippi A, Rule R. [Binding of tylosin, tilmicosin and oxytetracycline to proteins from honeybees, larvae and beehive products]. Rev Argent Microbiol. 2010;42:279-83 pubmed publisher
    ..present work was to determine, through a biological method, the protein binding of tylosin, tilmicosin and oxytetracycline to worker jelly; honey; pollen; adult bees and larvae in order to propose their kinetic routes...
  5. Chi Z, Liu R, Zhang H. Noncovalent interaction of oxytetracycline with the enzyme trypsin. Biomacromolecules. 2010;11:2454-9 pubmed publisher
    b>Oxytetracycline (OTC) is a kind of widely used veterinary drugs. The residue of OTC in the environment (e.g., animal food, soils, surface, and groundwater) is potentially harmful...
  6. Aristilde L, Marichal C, Miéhé Brendlé J, Lanson B, Charlet L. Interactions of oxytetracycline with a smectite clay: a spectroscopic study with molecular simulations. Environ Sci Technol. 2010;44:7839-45 pubmed publisher
    ..mechanisms of tetracycline antibiotics on smectite clays as a function of pH, we probed the interactions of oxytetracycline (OTC) with Na-montmorillonite (MONT) using X-ray diffraction (XRD), infrared (IR), and solid-state nuclear ..
  7. Tang Z, Xiao C, Zhuang Y, Chu J, Zhang S, Herron P, et al. Improved oxytetracycline production in Streptomyces rimosus M4018 by metabolic engineering of the G6PDH gene in the pentose phosphate pathway. Enzyme Microb Technol. 2011;49:17-24 pubmed publisher
    The aromatic polyketide antibiotic, oxytetracycline (OTC), is produced by Streptomyces rimosus as an important secondary metabolite...
  8. Liu M, Zhang Y, Yang M, Tian Z, Ren L, Zhang S. Abundance and distribution of tetracycline resistance genes and mobile elements in an oxytetracycline production wastewater treatment system. Environ Sci Technol. 2012;46:7551-7 pubmed publisher
    We investigated the abundance and distribution of tetracycline resistance genes (tet genes) in an oxytetracycline (OTC) antibiotic production wastewater (APW) treatment system...
  9. Schrickx J, Fink Gremmels J. P-glycoprotein-mediated transport of oxytetracycline in the Caco-2 cell model. J Vet Pharmacol Ther. 2007;30:25-31 pubmed
    ..b>Oxytetracycline (OTC) has been used for decennia in veterinary medicine for its extensive spectrum of antimicrobial activity...

More Information

Publications67

  1. Astobiza I, Barandika J, Hurtado A, Juste R, Garcia Perez A. Kinetics of Coxiella burnetii excretion in a commercial dairy sheep flock after treatment with oxytetracycline. Vet J. 2010;184:172-5 pubmed publisher
    ..In the following breeding cycle, 75% of the animals in the flock were double treated with oxytetracycline (OTC) at days +100 and +120 of gestation, while the remaining 25% of the animals were kept as untreated ..
  2. Singh M, Varshneya C, Telang R, Srivastava A. Alteration of pharmacokinetics of oxytetracycline following oral administration of Piper longum in hens. J Vet Sci. 2005;6:197-200 pubmed
    The pharmacokinetic profile of orally administered oxytetracycline (10 mg/kg body weight) was studied 7 days post oral treatment of Piper longum (15 mg equivalent/kg) in White Leghorn hens (2-2.8 kg)...
  3. Ci X, Chu X, Chen C, Li X, Yan S, Wang X, et al. Oxytetracycline attenuates allergic airway inflammation in mice via inhibition of the NF-?B pathway. J Clin Immunol. 2011;31:216-27 pubmed publisher
    b>Oxytetracycline has been used in the treatment of acute and chronic bronchial inflammation and infectious asthma. However, its potential use for non-infectious asthma has not yet been studied...
  4. Li J, Jiang F, Li Y, Chen Z. Fabrication of an oxytetracycline molecular-imprinted sensor based on the competition reaction via a GOD-enzymatic amplifier. Biosens Bioelectron. 2011;26:2097-101 pubmed publisher
    A highly sensitive molecular-imprinted polymer sensor (MIP sensor) for ultratrace oxytetracycline (OTC) determination was prepared based on the competition reaction between template molecule OTC and glucose oxidase (GOD)-labeled OTC (GOD-..
  5. Pickens L, Tang Y. Oxytetracycline biosynthesis. J Biol Chem. 2010;285:27509-15 pubmed publisher
    b>Oxytetracycline (OTC) is a broad-spectrum antibiotic that acts by inhibiting protein synthesis in bacteria. It is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products...
  6. Chi Z, Liu R, Yang B, Zhang H. Toxic interaction mechanism between oxytetracycline and bovine hemoglobin. J Hazard Mater. 2010;180:741-7 pubmed publisher
    b>Oxytetracycline (OTC) is a kind of widely used veterinary drugs. The residue of OTC in the environment is potentially harmful...
  7. Knapp C, Engemann C, Hanson M, Keen P, Hall K, Graham D. Indirect evidence of transposon-mediated selection of antibiotic resistance genes in aquatic systems at low-level oxytetracycline exposures. Environ Sci Technol. 2008;42:5348-53 pubmed
    ..To examine this issue, 15 mesocosms containing pristine surface water were treated with oxytetracycline (OTC) for 56 days at five levels (0, 5, 20, 50, and 250 microg L(-1)), and six tetracycline-resistance genes (..
  8. Nfon C, Makepeace B, Njongmeta L, Tanya V, Trees A. Lack of resistance after re-exposure of cattle cured of Onchocerca ochengi infection with oxytetracycline. Am J Trop Med Hyg. 2007;76:67-72 pubmed
    ..Using Onchocerca ochengi in cattle, an analog of human onchocerciasis, we have previously shown that oxytetracycline is macrofilaricidal, and protective immunity exists naturally in a subset of animals termed putatively immune...
  9. Kong W, Zhu Y, Liang Y, Zhang J, Smith F, Yang M. Uptake of oxytetracycline and its phytotoxicity to alfalfa (Medicago sativa L.). Environ Pollut. 2007;147:187-93 pubmed
    A series of experiments were conducted in a hydroponic system to investigate the uptake of oxytetracycline (OTC) and its toxicity to alfalfa (Medicago sativa L.)...
  10. Dang H, Zhao J, Song L, Chen M, Chang Y. Molecular characterizations of chloramphenicol- and oxytetracycline-resistant bacteria and resistance genes in mariculture waters of China. Mar Pollut Bull. 2009;58:987-94 pubmed publisher
    ..gene cat II, cat IV or floR could be detected in most of the multidrug-resistant isolates, and the oxytetracycline-resistance gene tet(B), tet(D), tet(E) or tet(M) could also be detected for most of the isolates...
  11. Zou T, Dou Y, Mi H, Zou J, Ren Y. Support vector regression for determination of component of compound oxytetracycline powder on near-infrared spectroscopy. Anal Biochem. 2006;355:1-7 pubmed
  12. Stevens D, Henry M, Murphy K, Boddy C. Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus. Appl Environ Microbiol. 2010;76:2681-3 pubmed publisher
    ..However, a "universal" host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential "universal" host for heterologous expression of polyketide biosynthetic gene clusters. ..
  13. Oliveira R, McDonough S, Ladewig J, Soares A, Nogueira A, Domingues I. Effects of oxytetracycline and amoxicillin on development and biomarkers activities of zebrafish (Danio rerio). Environ Toxicol Pharmacol. 2013;36:903-12 pubmed publisher
    ..This work aimed to assess the sub-lethal effects of oxytetracycline and amoxicillin on zebrafish development and biomarkers...
  14. Kaler J, Daniels S, Wright J, Green L. Randomized clinical trial of long-acting oxytetracycline, foot trimming, and flunixine meglumine on time to recovery in sheep with footrot. J Vet Intern Med. 2010;24:420-5 pubmed publisher
    ..Internationally, foot trimming is used by most farmers, and parenteral antibacterials by some, to treat sheep with footrot. Nonsteroidal anti-inflammatory drugs (NSAID) are sometimes used. No clinical trials have compared these treatments...
  15. Wassink G, King E, Grogono Thomas R, Brown J, Moore L, Green L. A within farm clinical trial to compare two treatments (parenteral antibacterials and hoof trimming) for sheep lame with footrot. Prev Vet Med. 2010;96:93-103 pubmed publisher
    ..We conclude that prompt parenteral and topical antibacterial treatment of sheep lame with ID and FR reduced the prevalence and incidence of these infectious conditions and led to improved health, welfare and productivity...
  16. Yang G, Zhang Q, Jin R. Changes in the nitrogen removal performance and the properties of granular sludge in an Anammox system under oxytetracycline (OTC) stress. Bioresour Technol. 2013;129:65-71 pubmed publisher
    The short- and long-term effects of oxytetracycline (OTC) on the anaerobic ammonium oxidation (Anammox) process were evaluated. The OTC inhibition of Anammox was substrate-, and especially nitrite-, dependent...
  17. Nishikawa A, Taguchi K. Healing of digital dermatitis after a single treatment with topical oxytetracycline in 89 dairy cows. Vet Rec. 2008;163:574-6 pubmed
  18. Niazi J, Lee S, Kim Y, Gu M. ssDNA aptamers that selectively bind oxytetracycline. Bioorg Med Chem. 2008;16:1254-61 pubmed
    Single stranded DNA aptamers that bind with high affinity and specificity to the oxytetracycline (OTC) were identified by selection from an oligonucleotide library of 10(15) molecules...
  19. Engemann C, Adams L, Knapp C, Graham D. Disappearance of oxytetracycline resistance genes in aquatic systems. FEMS Microbiol Lett. 2006;263:176-82 pubmed
    ..Treatments included simulated sunlight with 0, 25, and 250 microg L(-1) nominal oxytetracycline (OTC) levels, respectively, and 'dark' conditions...
  20. Rodriguez C, Lang L, Wang A, Altendorf K, Garcia F, Lipski A. Lettuce for human consumption collected in Costa Rica contains complex communities of culturable oxytetracycline- and gentamicin-resistant bacteria. Appl Environ Microbiol. 2006;72:5870-6 pubmed
    ..Farmers from nine sampling sites regularly apply commercial formulations containing gentamicin, oxytetracycline, streptomycin, or a combination of them without being able to indicate how often and how much of these ..
  21. Li K, Yediler A, Yang M, Schulte Hostede S, Wong M. Ozonation of oxytetracycline and toxicological assessment of its oxidation by-products. Chemosphere. 2008;72:473-8 pubmed publisher
    ..In the present study the effect of ozonation on the degradation of oxytetracycline (OTC) aqueous solution (100mgl(-1)) at different pH values (3, 7 and 11) was investigated...
  22. Wang L, Yang H, Zhang C, Mo Y, Lu X. Determination of oxytetracycline, tetracycline and chloramphenicol antibiotics in animal feeds using subcritical water extraction and high performance liquid chromatography. Anal Chim Acta. 2008;619:54-8 pubmed publisher
    A rapid analytical method for the determination of oxytetracycline (OTC), tetracycline (TC) and chloramphenicol (CAP) antibiotics in animal feeds has been developed based on subcritical water extraction (SWE) without further sample clean-..
  23. Nikolakopoulou T, Egan S, van Overbeek L, Guillaume G, Heuer H, Wellington E, et al. PCR detection of oxytetracycline resistance genes otr(A) and otr(B) in tetracycline-resistant streptomycete isolates from diverse habitats. Curr Microbiol. 2005;51:211-6 pubmed
    A range of European habitats was screened by PCR for detection of the oxytetracycline resistance genes otr(A) and otr(B), found in the oxytetracycline-producing strain Streptomyces rimosus...
  24. Yu L, Cao N, Wang L, Xiao C, Guo M, Chu J, et al. Oxytetracycline biosynthesis improvement in Streptomyces rimosus following duplication of minimal PKS genes. Enzyme Microb Technol. 2012;50:318-24 pubmed publisher
    b>Oxytetracycline (OTC) is a widely used antibiotic, which is commercially produced by Streptomyces rimosus. The type II minimal polyketide synthases (minimal PKS) genes of the oxytetracycline biosynthesis cluster in S...
  25. Ter Laak T, Wouter A, Tolls J. The effect of pH and ionic strength on the sorption of sulfachloropyridazine, tylosin, and oxytetracycline to soil. Environ Toxicol Chem. 2006;25:904-11 pubmed
    ..the soil sorption of three antimicrobial agents--sulfachloropyridazine (SCP), tylosin (TYL), and oxytetracycline (OTC)--was investigated. Their respective sorption coefficients in two agricultural soils ranged from 1...
  26. Nfon C, Makepeace B, Njongmeta L, Tanya V, Bain O, Trees A. Eosinophils contribute to killing of adult Onchocerca ochengi within onchocercomata following elimination of Wolbachia. Microbes Infect. 2006;8:2698-705 pubmed
    ..ochengi, we previously demonstrated that combined intensive and intermittent (COM) oxytetracycline treatment induces a sustained depletion of Wolbachia and is macrofilaricidal, whereas a short intensive ..
  27. Zhao C, Deng H, Li Y, Liu Z. Photodegradation of oxytetracycline in aqueous by 5A and 13X loaded with TiO2 under UV irradiation. J Hazard Mater. 2010;176:884-92 pubmed publisher
    The photocatalysis degradation, mineralization and detoxification of oxytetracycline (OTC) in aqueous were investigated by 5A and 13X zeolite with nano-TiO(2) loaded under UV light...
  28. Thompson H, Waite R, Wilkins S, Brown M, Bigwood T, Shaw M, et al. Effects of European foulbrood treatment regime on oxytetracycline levels in honey extracted from treated honeybee (Apis mellifera) colonies and toxicity to brood. Food Addit Contam. 2005;22:573-8 pubmed
    This study aimed to assess oxytetracycline (OTC) residue levels in honey up to 12 weeks after treatment of honeybee colonies with two methods of application (in liquid sucrose and in powdered icing sugar)...
  29. Novy P, Urban J, Leuner O, Vadlejch J, Kokoska L. In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus. J Antimicrob Chemother. 2011;66:1298-300 pubmed publisher
    ..in combinations with oxytetracycline and tetracycline on the growth of Staphylococcus aureus...
  30. Gujarathi N, Haney B, Linden J. Phytoremediation potential of Myriophyllum aquaticum and Pistia stratiotes to modify antibiotic growth promoters, tetracycline, and oxytetracycline, in aqueous wastewater systems. Int J Phytoremediation. 2005;7:99-112 pubmed
    ..and Pistia stratiotes (water lettuce), were used for studying phytoremediation of tetracycline (TC) and oxytetracycline (OTC) from aqueous media. TC and OTC are two of the most commonly used tetracyclines in veterinary medicine...
  31. Gozubuyuk A, Ozpolat B, Ciçek A, Caylak H, Yucel O, Kavakli K, et al. Comparison of side effects of oxytetracycline and talc pleurodesis: an experimental study. J Cardiothorac Surg. 2010;5:128 pubmed publisher
    ..Talc is the most commonly used agent for the treatment, with rare, serious complications reported. Oxytetracycline pleurodesis in clinical practice has been described in a few studies, but literature reveals no experimental ..
  32. Li D, Yu T, Zhang Y, Yang M, Li Z, Liu M, et al. Antibiotic resistance characteristics of environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river. Appl Environ Microbiol. 2010;76:3444-51 pubmed publisher
    We characterized the bacterial populations in surface water receiving effluent from an oxytetracycline (OTC) production plant...
  33. Seyfried E, Newton R, Rubert K, Pedersen J, McMahon K. Occurrence of tetracycline resistance genes in aquaculture facilities with varying use of oxytetracycline. Microb Ecol. 2010;59:799-807 pubmed publisher
    ..The purpose of this study was to determine if oxytetracycline (OTC) use in aquaculture facilities increased the detection frequency (i.e...
  34. Fortt Z A, Cabello C F, Buschmann R A. [Residues of tetracycline and quinolones in wild fish living around a salmon aquaculture center in Chile]. Rev Chilena Infectol. 2007;24:14-8 pubmed
    ..More studies are needed in Chile to determine the relevance of these findings for human and animal health and the environment to regulate this use of antibiotics. ..
  35. Jiao S, Zheng S, Yin D, Wang L, Chen L. Aqueous oxytetracycline degradation and the toxicity change of degradation compounds in photoirradiation process. J Environ Sci (China). 2008;20:806-13 pubmed
    The extensive use of antibiotics has been a worldwide environmental issue. In this study the fate of oxytetracycline (OTC), under photoirradiation, was investigated...
  36. Brentnall C, Cheng Z, McKellar Q, Lees P. Pharmacokinetic-pharmacodynamic integration and modelling of oxytetracycline administered alone and in combination with carprofen in calves. Res Vet Sci. 2013;94:687-94 pubmed publisher
    The pharmacokinetic (PK) and pharmacodynamic (PD) profiles of oxytetracycline were investigated, when administered both alone and in the presence of carprofen, in healthy calves...
  37. Kim Y, Niazi J, Gu M. Specific detection of oxytetracycline using DNA aptamer-immobilized interdigitated array electrode chip. Anal Chim Acta. 2009;634:250-4 pubmed publisher
    An electrochemical sensing system for oxytetracycline (OTC) detection was developed using ssDNA aptamer immobilized on gold interdigitated array (IDA) electrode chip...
  38. Oleszczuk P, Pan B, Xing B. Adsorption and desorption of oxytetracycline and carbamazepine by multiwalled carbon nanotubes. Environ Sci Technol. 2009;43:9167-73 pubmed publisher
    We investigated the adsorption-desorption by multiwalled carbon nanotubes (MWCNTs) of two pharmaceuticals, oxytetracycline (OTC) and carbamazepine (CBZ). The pharmaceuticals demonstrated relatively fast sorption kinetics on MWCNTs...
  39. Kaler J, Wani S, Hussain I, Beg S, Makhdoomi M, Kabli Z, et al. A clinical trial comparing parenteral oxytetracyline and enrofloxacin on time to recovery in sheep lame with acute or chronic footrot in Kashmir, India. BMC Vet Res. 2012;8:12 pubmed publisher
    ..footrot were allocated to one of three treatments using stratified random sampling: long acting parenteral oxytetracycline, long acting parenteral enrofloxacin and topical application of potassium permanganate solution (a ..
  40. Carrasquillo A, Bruland G, Mackay A, Vasudevan D. Sorption of ciprofloxacin and oxytetracycline zwitterions to soils and soil minerals: influence of compound structure. Environ Sci Technol. 2008;42:7634-42 pubmed
    b>Oxytetracycline (OTC) zwitterions sorbed to a greater extent than ciprofloxacin (CIP) zwitterions onto goethite and soils with moderate-to-low effective cation exchange capacities (ECEC < 10 cmol(c)/kg) because adjacent pairs of ..
  41. Figueroa R, Mackay A. Sorption of oxytetracycline to iron oxides and iron oxide-rich soils. Environ Sci Technol. 2005;39:6664-71 pubmed
    The sorption interactions of oxytetracycline with goethite, hematite, and two iron oxide-rich soils were investigated using batch sorption experiments...
  42. Zhang Y, Cai X, Lang X, Qiao X, Li X, Chen J. Insights into aquatic toxicities of the antibiotics oxytetracycline and ciprofloxacin in the presence of metal: complexation versus mixture. Environ Pollut. 2012;166:48-56 pubmed publisher
    ..The complexation of two antibiotics, oxytetracycline and ciprofloxacin, with three heavy metals, copper, zinc, and cadmium, was verified by spectroscopic ..
  43. Kim Y, Kim J, Kim I, Lee S, Jurng J, Gu M. A novel colorimetric aptasensor using gold nanoparticle for a highly sensitive and specific detection of oxytetracycline. Biosens Bioelectron. 2010;26:1644-9 pubmed publisher
    ..a novel colorimetric aptasensor using gold nanoparticles for highly sensitive and specific detection of oxytetracycline (OTC), one of the most common antibacterial agents...
  44. Berry S, Read D, Walker R, Famula T. Clinical, histologic, and bacteriologic findings in dairy cows with digital dermatitis (footwarts) one month after topical treatment with lincomycin hydrochloride or oxytetracycline hydrochloride. J Am Vet Med Assoc. 2010;237:555-60 pubmed publisher
    To compare the effectiveness of lincomycin and oxytetracycline for treatment of digital dermatitis (DD) in dairy cows through gross visual examination, histologic evaluation, and bacteriologic evaluation.
  45. Moreira F, Kamel A, Guerreiro J, Sales M. Man-tailored biomimetic sensor of molecularly imprinted materials for the potentiometric measurement of oxytetracycline. Biosens Bioelectron. 2010;26:566-74 pubmed publisher
    A novel biomimetic sensor for the potentiometric transduction of oxytetracycline is presented. The artificial host was imprinted in methacrylic acid and/or acrylamide based polymers...
  46. Boleas S, Alonso C, Pro J, Fernandez C, Carbonell G, Tarazona J. Toxicity of the antimicrobial oxytetracycline to soil organisms in a multi-species-soil system (MS.3) and influence of manure co-addition. J Hazard Mater. 2005;122:233-41 pubmed
    The effects of oxytetracycline (OTC) on soil organisms have been studied using a multi-species-soil system (MS.3). Oxytetracycline concentrations of 0...
  47. Li J, Jiang F, Wei X. Molecularly imprinted sensor based on an enzyme amplifier for ultratrace oxytetracycline determination. Anal Chem. 2010;82:6074-8 pubmed publisher
    ..for preparing highly sensitive, molecularly imprinted sensors based on enzyme amplifiers was proposed for oxytetracycline (OTC) determination...
  48. Zhang W, Ames B, Tsai S, Tang Y. Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase. Appl Environ Microbiol. 2006;72:2573-80 pubmed
    ..To this end, we have sequenced the gene cluster of oxytetracycline (oxy and otc genes) PKS genes from Streptomyces rimosus...
  49. Bakke McKellep A, Penn M, Salas P, Refstie S, Sperstad S, Landsverk T, et al. Effects of dietary soyabean meal, inulin and oxytetracycline on intestinal microbiota and epithelial cell stress, apoptosis and proliferation in the teleost Atlantic salmon (Salmo salar L.). Br J Nutr. 2007;97:699-713 pubmed
    ..fishmeal (FM) as the sole protein source, responses to extracted SBM or the prebiotic inulin, with or without oxytetracycline (OTC) inclusion, were studied following a 3-week feeding trial...
  50. Rose P, Pedersen J. Fate of oxytetracycline in streams receiving aquaculture discharges: model simulations. Environ Toxicol Chem. 2005;24:40-50 pubmed
    The potential aquatic fate of oxytetracycline (OTC) in streams receiving discharge from fish hatcheries was examined using the Water-Quality Analysis Simulation Program (WASP, Ver 6.1) model. The modeled 4...
  51. Coetzee J, Apley M, Kocan K, Rurangirwa F, Van Donkersgoed J. Comparison of three oxytetracycline regimes for the treatment of persistent Anaplasma marginale infections in beef cattle. Vet Parasitol. 2005;127:61-73 pubmed
    ..This study tested the efficacy of three oxytetracycline treatment regimens to clear A. marginale from cattle that were persistently infected...
  52. Lubbers B, Peterson G, Narayanan S, Havel J, Coetzee J, Apley M. Effects of two simulated oxytetracycline dosing regimens on horizontal transfer of antimicrobial resistance plasmids in an in vitro pharmacodynamic model. Am J Vet Res. 2011;72:877-83 pubmed publisher
    To evaluate the impact of oxytetracycline exposure on horizontal transfer of an antimicrobial resistance plasmid. Populations of Salmonella enterica subsp enterica serovar Typhimurium and Escherichia coli...
  53. Hanson M, Knapp C, Graham D. Field assessment of oxytetracycline exposure to the freshwater macrophytes Egeria densa Planch. and Ceratophyllum demersum L. Environ Pollut. 2006;141:434-42 pubmed
    ..densa and Ceratophyllum demersum were exposed to nominal concentrations of 0, 5, 20, 50, and 250 microg/L oxytetracycline (n=3), plus 20 microg/L oxytetracycline amended with additional nitrogen (N) and phosphorus (P)...
  54. Ayling R, Bisgaard Frantzen S, March J, Godinho K, Nicholas R. Assessing the in vitro effectiveness of antimicrobials against Mycoplasma mycoides subsp. mycoides small-colony type to reduce contagious bovine pleuropneumonia infection. Antimicrob Agents Chemother. 2005;49:5162-5 pubmed
    ..Of the antimicrobials used most widely in Africa, oxytetracycline and tilmicosin were effective, while the isolates were resistant to tylosin...
  55. Pari L, Gnanasoundari M. Influence of naringenin on oxytetracycline mediated oxidative damage in rat liver. Basic Clin Pharmacol Toxicol. 2006;98:456-61 pubmed
    ..was carried out to evaluate the effect of naringenin on antioxidant and lipid peroxidation status in liver of oxytetracycline-intoxicated rats...
  56. Yildirim E, Dural K, Yazkan R, Zengin N, Yildirim D, Gunal N, et al. Rapid pleurodesis in symptomatic malignant pleural effusion. Eur J Cardiothorac Surg. 2005;27:19-22 pubmed
    ..A small-bore catheter (12 Fr) and oxytetracycline (35 mg/kg of body weight) were used in both groups...
  57. Ferreira C, Nunes B, Henriques Almeida J, Guilhermino L. Acute toxicity of oxytetracycline and florfenicol to the microalgae Tetraselmis chuii and to the crustacean Artemia parthenogenetica. Ecotoxicol Environ Saf. 2007;67:452-8 pubmed
    ..The antibacterials oxytetracycline (OTC) and florfenicol (FLO) have been widely used in aquaculture...
  58. Kong W, Zhu Y, Fu B, Marschner P, He J. The veterinary antibiotic oxytetracycline and Cu influence functional diversity of the soil microbial community. Environ Pollut. 2006;143:129-37 pubmed
    ..The widely used veterinary antibiotic oxytetracycline (OTC), Cu and their combination on soil microbial community function were assessed with the Biolog method...