amitriptyline

Summary

Summary: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.

Top Publications

  1. Hu Y, Yang J, Hu Y, Wang Y, Li W. Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory. Eur J Anaesthesiol. 2010;27:162-8 pubmed publisher
    ..investigate the effects and possible mechanisms of neuropathic pain on learning and memory, and the effects of amitriptyline and lornoxicam on cognitive function...
  2. Jang S, Liu X, Chan C, Weinshenker D, Hall R, Xiao G, et al. Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol. 2009;16:644-56 pubmed publisher
    ..We report here that amitriptyline, an antidepressant drug, directly binds TrkA and TrkB and triggers their dimerization and activation...
  3. Vanelderen P, Rouwette T, Kozicz T, Heylen R, Van Zundert J, Roubos E, et al. Effects of chronic administration of amitriptyline, gabapentin and minocycline on spinal brain-derived neurotrophic factor expression and neuropathic pain behavior in a rat chronic constriction injury model. Reg Anesth Pain Med. 2013;38:124-30 pubmed publisher
    ..No data are available on the effect of amitriptyline and gabapentin on spinal BDNF expression...
  4. Kajitani N, Hisaoka Nakashima K, Morioka N, Okada Tsuchioka M, Kaneko M, Kasai M, et al. Antidepressant acts on astrocytes leading to an increase in the expression of neurotrophic/growth factors: differential regulation of FGF-2 by noradrenaline. PLoS ONE. 2012;7:e51197 pubmed publisher
    ..Treatment with amitriptyline (a tricyclic antidepressant) significantly increased the expression of fibroblast growth factor-2 (FGF-2), ..
  5. Wichniak A, Wierzbicka A. [The effects of antidepressants on sleep in depressed patients with particular reference to trazodone in comparison to agomelatine, amitriptyline, doxepin, mianserine and mirtazapine]. Pol Merkur Lekarski. 2011;31:65-70 pubmed
    ..trazodone on sleep in depressed patients in comparison to other sleep promoting antidepressants: agomelatine, amitriptyline, doxepin, mianserine and mirtazapine according to analysis of scientific publications...
  6. Cordero M, Sánchez Alcázar J, Bautista Ferrufino M, Carmona López M, Illanes M, Rios M, et al. Acute oxidant damage promoted on cancer cells by amitriptyline in comparison with some common chemotherapeutic drugs. Anticancer Drugs. 2010;21:932-44 pubmed publisher
    ..We focused our investigations on the antitumoral potential of amitriptyline in three human tumor cell lines: H460 (lung cancer), HeLa (cervical cancer), and HepG2 (hepatoma); comparing ..
  7. Boyle J, Eriksson M, Gribble L, Gouni R, Johnsen S, Coppini D, et al. Randomized, placebo-controlled comparison of amitriptyline, duloxetine, and pregabalin in patients with chronic diabetic peripheral neuropathic pain: impact on pain, polysomnographic sleep, daytime functioning, and quality of life. Diabetes Care. 2012;35:2451-8 pubmed publisher
    ..The objectives of this study were to compare the analgesic efficacy of pregabalin, amitriptyline, and duloxetine, and their effect on polysomnographic sleep, daytime functioning, and quality of life in ..
  8. Olgun H, Yildirim Z, Karacan M, Ceviz N. Clinical, electrocardiographic, and laboratory findings in children with amitriptyline intoxication. Pediatr Emerg Care. 2009;25:170-3 pubmed publisher
    b>Amitriptyline is one of the major tricyclic antidepressants, and the data on amitriptyline poisoning in children are limited...
  9. Jarosik J, Legutko B, Werner S, Unsicker K, von Bohlen und Halbach O. Roles of exogenous and endogenous FGF-2 in animal models of depression. Restor Neurol Neurosci. 2011;29:153-65 pubmed publisher
    ..FGF-2, similar to the antidepressant amitriptyline, attenuated neuron demise in the piriform cortex and posterolateral cortical nucleus of the amygdala following ..

More Information

Publications62

  1. Yan L, Wang Q, Fu Q, Ye Q, Xiao H, Wan Q. Amitriptyline inhibits currents and decreases the mRNA expression of voltage-gated sodium channels in cultured rat cortical neurons. Brain Res. 2010;1336:1-9 pubmed publisher
    b>Amitriptyline (AMI) is widely used for migraine prophylaxis, but its mechanism is undetermined...
  2. Li B, Lefevre F, Chelimsky G, Boles R, Nelson S, Lewis D, et al. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition consensus statement on the diagnosis and management of cyclic vomiting syndrome. J Pediatr Gastroenterol Nutr. 2008;47:379-93 pubmed publisher
    ..include lifestyle changes, prophylactic therapy (eg, cyproheptadine in children 5 years or younger and amitriptyline for those older than 5), and acute therapy (eg, 5-hydroxytryptamine receptor agonists, termed triptans herein, ..
  3. Moore R, Derry S, Aldington D, Cole P, Wiffen P. Amitriptyline for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2012;12:CD008242 pubmed publisher
    b>Amitriptyline is a tricyclic antidepressant that is widely used to treat chronic neuropathic pain (pain due to nerve damage) and fibromyalgia, and is recommended in many guidelines...
  4. Darwish M, Hellriegel E, Xie F. Single-dose pharmacokinetics of once-daily cyclobenzaprine extended release 30 mg versus cyclobenzaprine immediate release 10 mg three times daily in healthy young adults : a randomized, open-label, two-period crossover, single-centre study. Clin Drug Investig. 2008;28:793-801 pubmed publisher
    ..CER 30 mg once daily and CIR 10 mg three times daily resulted in comparable systemic exposures. ..
  5. Hisaoka K, Tsuchioka M, Yano R, Maeda N, Kajitani N, Morioka N, et al. Tricyclic antidepressant amitriptyline activates fibroblast growth factor receptor signaling in glial cells: involvement in glial cell line-derived neurotrophic factor production. J Biol Chem. 2011;286:21118-28 pubmed publisher
    ..The amitriptyline (a tricyclic antidepressant)-induced ERK activation was specifically and completely inhibited by fibroblast ..
  6. Arsenault A, Sawynok J. Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury. Pain. 2009;146:308-14 pubmed publisher
    ..Here we demonstrate that a perioperative regimen of amitriptyline (10 mg/kg i.p...
  7. Banerjee M, Pal S, Bhattacharya B, Ghosh B, Mondal S, Basu J. A comparative study of efficacy and safety of gabapentin versus amitriptyline as coanalgesics in patients receiving opioid analgesics for neuropathic pain in malignancy. Indian J Pharmacol. 2013;45:334-8 pubmed publisher
    To assess the efficacy and safety of gabapentin and amitriptyline along with opioids in patients suffering from neuropathic pain in malignancy...
  8. Mao Q, Yang T. Amitriptyline upregulates EAAT1 and EAAT2 in neuropathic pain rats. Brain Res Bull. 2010;81:424-7 pubmed publisher
    ..The present study was performed to evaluate the effects of the tricyclic antidepressant amitriptyline on the expressions of EAATs in neuropathic pain rats...
  9. Liang J, Yu S, Dong Z, Wang X, Liu R, Chen X, et al. The effects of OB-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus. Brain Res. 2011;1424:9-19 pubmed publisher
    ..Systemic administration of the antidepressant amitriptyline (AMI) significantly alleviated nociceptive behaviors in both the OB rats and Sham rats...
  10. Braak B, Klooker T, Wouters M, Lei A, van Den Wijngaard R, Boeckxstaens G. Randomised clinical trial: the effects of amitriptyline on drinking capacity and symptoms in patients with functional dyspepsia, a double-blind placebo-controlled study. Aliment Pharmacol Ther. 2011;34:638-48 pubmed publisher
    Functional dyspepsia is one of the most prevalent (15-40%) functional gastrointestinal disorders. Antidepressants such as amitriptyline are often used in these patients, but clinical studies are currently lacking.
  11. Celik U, Celik T, Avci A, Annagur A, Yilmaz H, Kucukosmanoglu O, et al. Metabolic acidosis in a patient with type 1 diabetes mellitus complicated by methanol and amitriptyline intoxication. Eur J Emerg Med. 2009;16:45-8 pubmed publisher
    ..Further laboratory tests detected methanol and amitriptyline. The patient underwent hemodialysis and recovered completely...
  12. Kalkan S, Oransay K, Bal I, Ertunc M, Sara Y, Iskit A. The role of adenosine receptors on amitriptyline-induced electrophysiological changes on rat atrium. Hum Exp Toxicol. 2013;32:62-9 pubmed publisher
    We investigated the role of adenosine receptors in amitriptyline-induced cardiac action potential (AP) changes in isolated rat atria...
  13. Uhr M, Steckler T, Yassouridis A, Holsboer F. Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption. Neuropsychopharmacology. 2000;22:380-7 pubmed
    ..the effect of the absence of the drug-transporting P-glycoprotein at the blood-brain barrier on the uptake of amitriptyline (AMI) and fluoxetine (FLU) and their metabolites into the brain...
  14. Darwish M, Chang S, Hellriegel E. A pharmacokinetic comparison of single doses of once-daily cyclobenzaprine extended-release 15 mg and 30 mg: a randomized, double-blind, two-period crossover study in healthy volunteers. Clin Ther. 2009;31:108-14 pubmed publisher
    ..AUC(0-168), AUC(0-infinity)), and C(max) values for the 30-mg dose were approximately double those for the 15-mg dose, a result consistent with previously reported data on the dose proportionality of cyclobenzaprine immediate release. ..
  15. Xiao W, Naso L, Bennett G. Experimental studies of potential analgesics for the treatment of chemotherapy-evoked painful peripheral neuropathies. Pain Med. 2008;9:505-17 pubmed
    ..b>Amitriptyline produced significant analgesia, but this was not apparent until after the second injection...
  16. Ji C, Fan D, Li W, Guo L, Liang Z, Xu R, et al. Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in rats. Eur J Pharmacol. 2012;691:46-51 pubmed publisher
    The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and fluoxetine were compared in experimental models of gastric ulcer in rats...
  17. Moghadamnia A, Partovi M, Mohammadianfar I, Madani Z, Zabihi E, Hamidi M, et al. Evaluation of the effect of locally administered amitriptyline gel as adjunct to local anesthetics in irreversible pulpitis pain. Indian J Dent Res. 2009;20:3-6 pubmed
    b>Amitriptyline is one of the most common tricyclic antidepressants, which binds to pain sensory nerve fibers close to the sodium channel; hence, it could interact to some degree with receptors of local anesthetics...
  18. Darwish M, Xie F. Effect of food on the pharmacokinetics of once-daily cyclobenzaprine extended-release 30 mg: a randomized, open-label, crossover, single-centre study. Clin Drug Investig. 2009;29:145-52 pubmed publisher
    ..CER 30 mg was generally well tolerated, with comparable adverse events in both the fed and the fasted states. The increase in exposure did not appear to impact the tolerability of the formulation. ..
  19. McGeary J, Gurel V, Knopik V, Spaulding J, McMichael J. Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain. Neuropeptides. 2011;45:317-22 pubmed publisher
    ..genes in the amygdala/hippocampus were determined in rats treated for 14days with NGF, fluoxetine, amitriptyline, or saline...
  20. Tai Y, Tsai R, Lin S, Yeh C, Wang J, Tao P, et al. Amitriptyline suppresses neuroinflammation-dependent interleukin-10-p38 mitogen-activated protein kinase-heme oxygenase-1 signaling pathway in chronic morphine-infused rats. Anesthesiology. 2009;110:1379-89 pubmed publisher
    This study explores the underlying mechanism of the antiinflammatory effect of amitriptyline in chronic morphine-infused rats. Male Wistar rats were implanted with two intrathecal catheters...
  21. Zhang Z, Du X, Zhao C, Cao B, Zhao Y, Mao X. The antidepressant amitriptyline shows potent therapeutic activity against multiple myeloma. Anticancer Drugs. 2013;24:792-8 pubmed publisher
    Our previous study indicated that the antidepressant amitriptyline showed potent activity in inducing multiple myeloma (MM) cell apoptosis in vitro. In the present study, we further showed that amitriptyline was active against MM in vivo...
  22. Zoladz P, Fleshner M, Diamond D. Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD. Prog Neuropsychopharmacol Biol Psychiatry. 2013;44:1-16 pubmed publisher
    ..Beginning 24 h after the first cat exposure, rats received daily injections of amitriptyline, clonidine, tianeptine or vehicle...
  23. Pilhatsch M, Wolf R, Winter C, Lewitzka U, Bauer M. Comparison of paroxetine and amitriptyline as adjunct to lithium maintenance therapy in bipolar depression: a reanalysis of a randomized, double-blind study. J Affect Disord. 2010;126:453-7 pubmed publisher
    To compare the efficacy and safety of adjunctive treatment with paroxetine or amitriptyline in patients with bipolar disorder who relapsed into a depressive episode during lithium maintenance therapy...
  24. Boles R, Lovett Barr M, Preston A, Li B, Adams K. Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study. BMC Neurol. 2010;10:10 pubmed publisher
    ..Subjects taking Co-Q (22 subjects) were compared against those taking amitriptyline (162 subjects), which is the general standard-of-care...
  25. Fukushima F, Barros G, Marques M, Vidal E, Ganem E. The neuraxial effects of intraspinal amitriptyline at low concentrations. Anesth Analg. 2009;109:965-71 pubmed publisher
    As a result of amitriptyline's vast array of actions, it could potentially be used as an intraspinal adjuvant in neuraxial anesthesia and/or in the treatment of refractory neuropathic pain...
  26. Uhr M, Grauer M, Yassouridis A, Ebinger M. Blood-brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controls. J Psychiatr Res. 2007;41:179-88 pubmed
    ..knock-out mice, we showed that P-gp exports the antidepressants citalopram, paroxetine, venlafaxine and amitriptyline and its metabolites across the blood-brain barrier, thereby reducing cerebral bioavailability of some ..
  27. Cotella E, Mestres Lascano I, Franchioni L, Levin G, Suarez M. Long-term effects of maternal separation on chronic stress response suppressed by amitriptyline treatment. Stress. 2013;16:477-81 pubmed publisher
    ..known to correct glucocorticoid hypersecretion during depression, we treated maternally separated animals with amitriptyline, at a lower dose than habitually used in depression models, to prevent the response to chronic stress during ..
  28. Foster H, Hanno P, Nickel J, Payne C, Mayer R, BURKS D, et al. Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome. J Urol. 2010;183:1853-8 pubmed publisher
    b>Amitriptyline is frequently used to treat patients with interstitial cystitis/painful bladder syndrome. The evidence to support this practice is derived mainly from a small, single site clinical trial and case reports...
  29. Akgun Arici M, Kalkan S, Demir O, Hocaoglu Aksay N, Gidener S, Tuncok Y. Does adenosine A(1) receptor stimulation causes QRS prolongation by blocking beta adrenergic receptors in amitriptyline poisoning?. Toxicol Lett. 2009;186:130-8 pubmed publisher
    To investigate the role of beta receptor blockade via adenosine A(1) receptor stimulation on amitriptyline-induced QRS prolongation. Isolated rat hearts were randomized into three groups (n=8 for each group)...
  30. Freysoldt A, Fleckenstein J, Lang P, Irnich D, Grafe P, Carr R. Low concentrations of amitriptyline inhibit nicotinic receptors in unmyelinated axons of human peripheral nerve. Br J Pharmacol. 2009;158:797-805 pubmed publisher
    b>Amitriptyline is often prescribed as a first-line treatment for neuropathic pain but its precise mode of analgesic action remains uncertain...
  31. Nährlich L, Mainz J, Adams C, Engel C, Herrmann G, Icheva V, et al. Therapy of CF-patients with amitriptyline and placebo--a randomised, double-blind, placebo-controlled phase IIb multicenter, cohort-study. Cell Physiol Biochem. 2013;31:505-12 pubmed publisher
    ..of ceramide concentrations in lungs of CF mice employing the functional acid sphingomyelinase inhibitor amitriptyline also normalized mucociliary clearance, chronic inflammation and infection susceptibility to pulmonary P...
  32. Kopsky D, Hesselink J. High doses of topical amitriptyline in neuropathic pain: two cases and literature review. Pain Pract. 2012;12:148-53 pubmed publisher
    ..The aim of this article is to describe two cases treated effectively with topical amitriptyline 5% and 10%, the highest dosage described to date...
  33. Darwish M, Hellriegel E. Steady-state pharmacokinetics of once-daily cyclobenzaprine extended release: a randomized, double-blind, 2-period crossover study in healthy volunteers. Clin Ther. 2011;33:746-53 pubmed publisher
    ..Once-daily CER 30 mg delivered sustained plasma cyclobenzaprine levels over 24 hours at steady state. Owing to a protocol violation, steady-state pharmacokinetic properties for CIR could not be assessed. ..
  34. Baik H, Lee S, Washington J, Zuo Z. Amitriptyline inhibits the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes. J Pharm Pharmacol. 2009;61:577-81 pubmed publisher
    ..We have investigated the effects of amitriptyline, a tricyclic antidepressant, on the activity of the excitatory amino acid transporter type 3 (EAAT3), a ..
  35. Liu J, Reid A, Sawynok J. Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline. Eur J Pharmacol. 2013;698:213-9 pubmed publisher
    ..study explored a link between spinal 5-HT(7) and adenosine A(1) receptors in antinociception by systemic amitriptyline in normal and adenosine A(1) receptor knock-out mice using the 2% formalin test...
  36. Su X, Liang A, Urban M. The effect of amitriptyline on ectopic discharge of primary afferent fibers in the L5 dorsal root in a rat model of neuropathic pain. Anesth Analg. 2009;108:1671-9 pubmed publisher
    The sodium channel blocker amitriptyline has been shown to inhibit ectopic discharge in injured nerves...
  37. Hajhashemi V, Sadeghi H, Minaiyan M, Movahedian A, Talebi A. The role of central mechanisms in the anti-inflammatory effect of amitriptyline on carrageenan-induced paw edema in rats. Clinics (Sao Paulo). 2010;65:1183-7 pubmed
    The present study was designed to further investigate the effect of amitriptyline, a classical tricyclic antidepressant, on carrageenan-induced paw edema in rats. First, amitriptyline was administered intraperitoneally (i.p...
  38. Mahmood D, Akhtar M, Vohora D, Khanam R. Comparison of antinociceptive and antidiabetic effects of sertraline and amitriptyline on streptozotocin-induced diabetic rats. Hum Exp Toxicol. 2010;29:881-6 pubmed publisher
    ..The aim of this study is to investigate the antinociceptive effects of sertraline (Ser) and amitriptyline (Ami) in diabetic rats, and additionally monitoring their effects on grip strength, blood glucose and ..
  39. Jesse C, Wilhelm E, Nogueira C. Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion. Psychopharmacology (Berl). 2010;212:513-22 pubmed publisher
    ..The present study determined the effect of bis selenide and conventional antidepressants (fluoxetine, amitriptyline, and bupropion) on neuropathic pain using mechanical allodynic and on depressive-like behavior...
  40. Densmore V, Kalous A, Keast J, Osborne P. Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. Pain. 2010;151:184-93 pubmed publisher
    ..in treating neuropathic SCI pain, but their duration of action differed significantly, showing a rank order of amitriptyline (24-48 h)?morphine (6 h)>gabapentin (2 h)...
  41. Wu W, Ye Q, Wang W, Yan L, Wang Q, Xiao H, et al. Amitriptyline modulates calcium currents and intracellular calcium concentration in mouse trigeminal ganglion neurons. Neurosci Lett. 2012;506:307-11 pubmed publisher
    ..In the present study, effects of amitriptyline (AMT), a commonly used migraine prophylactic drug, on the HVA calcium currents (I(Ca)) were examined in mouse ..
  42. Chadwick W, Mitchell N, Caroll J, Zhou Y, Park S, Wang L, et al. Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. PLoS ONE. 2011;6:e21660 pubmed publisher
    ..In this study, amitriptyline, an FDA-approved tricyclic antidepressant, was administered orally to aged and cognitively impaired transgenic ..
  43. Bansal D, Bhansali A, Hota D, Chakrabarti A, Dutta P. Amitriptyline vs. pregabalin in painful diabetic neuropathy: a randomized double blind clinical trial. Diabet Med. 2009;26:1019-26 pubmed publisher
    To compare the efficacy and safety of pregabalin and amitriptyline in alleviating pain associated with diabetic peripheral neuropathy...
  44. Raigrodski A, Mohamed S, Gardiner D. The effect of amitriptyline on pain intensity and perception of stress in bruxers. J Prosthodont. 2001;10:73-7 pubmed
    The purpose of this clinical pilot study was to evaluate the effect of a tricyclic antidepressant, amitriptyline, on pain-intensity level and level of stress in bruxers...
  45. Hisaoka K, Takebayashi M, Tsuchioka M, Maeda N, Nakata Y, Yamawaki S. Antidepressants increase glial cell line-derived neurotrophic factor production through monoamine-independent activation of protein tyrosine kinase and extracellular signal-regulated kinase in glial cells. J Pharmacol Exp Ther. 2007;321:148-57 pubmed
    ..Here, we found that amitriptyline, a tricyclic antidepressant, increased both GDNF mRNA expression and release, which were selectively and ..
  46. Deegan C, O Brien K. Amitriptyline poisoning in a 2-year old. Paediatr Anaesth. 2006;16:174-7 pubmed
    We describe a case of a 2-year-old boy who ingested 35 mg.kg(-1) of amitriptyline. He developed central nervous system toxicity, as demonstrated by coma and seizures and cardiac toxicity (cardiac arrest) within 1 h of ingestion...
  47. Abdel Salam O, Nofal S, el Shenawy S. Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. Pharmacol Res. 2003;48:157-65 pubmed
    ..The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation...
  48. Raigrodski A, Christensen L, Mohamed S, Gardiner D. The effect of four-week administration of amitriptyline on sleep bruxism. A double-blind crossover clinical study. Cranio. 2001;19:21-5 pubmed
    The purpose of this study was to evaluate the effect of a tricyclic antidepressant (amitriptyline) on nocturnal masseteric activity and duration of sleep in bruxists...
  49. Nishishinya B, Urrutia G, Walitt B, Rodriguez A, Bonfill X, Alegre C, et al. Amitriptyline in the treatment of fibromyalgia: a systematic review of its efficacy. Rheumatology (Oxford). 2008;47:1741-6 pubmed publisher
    The objective of this study was to assess the efficacy and safety of amitriptyline as a treatment of FM. A comprehensive computerized search in Medline (Pubmed), EMBASE and The Cochrane Library was performed...
  50. Antonini A, Tesei S, Zecchinelli A, Barone P, De Gaspari D, Canesi M, et al. Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: effect on quality of life. Mov Disord. 2006;21:1119-22 pubmed
    We assessed the effect of 3-month treatment of sertraline (50 mg) or low-dose amitriptyline (25 mg) on depression and quality of life in 31 patients with Parkinson's disease in a prospective single-blind randomized study...
  51. Sawynok J, Reid A, Fredholm B. Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors. Neurosci Lett. 2008;440:181-4 pubmed publisher
    b>Amitriptyline is used to treat neuropathic pain in humans...
  52. Takeda Y, Ishida T, Tsutsui R, Toide K, Tanimoto Mori S, Watanabe S, et al. Studies on somnolence in the daytime caused by drugs used for neuropathic pain. J Pharmacol Sci. 2008;107:246-50 pubmed
    In the present study, the characteristics of the sleep features of amitriptyline, mexiletine, and N-(4-tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyradine-1(2H)-carbox-amide (BCTC) were studied...
  53. Sung B, Wang G. Peripherally administered amitriptyline derivatives have differential anti-allodynic effects in a rat model of neuropathic pain. Neurosci Lett. 2004;357:115-8 pubmed
    We assessed if derivatives of amitriptyline could alleviate mechanical allodynia in a rat model of neuropathic pain...