methylcholanthrene

Summary

Summary: A carcinogen that is often used in experimental cancer studies.

Top Publications

  1. Xue X, Xiao Y, Zhu H, Wang H, Liu Y, Xie T, et al. Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury. Nephrol Dial Transplant. 2008;23:3074-81 pubmed publisher
    ..This study was designed to investigate whether P450 1A plays a role in AAI-induced renal injury in C57BL/6 mice...
  2. Jennings Gee J, Moore J, Xu M, Dance S, Kock N, McCoy T, et al. Strain-specific induction of murine lung tumors following in utero exposure to 3-methylcholanthrene. Mol Carcinog. 2006;45:676-84 pubmed
    ..x DBA2) backcross exhibited a high incidence of lung tumors 12-13 mo after transplacental exposure to 3-methylcholanthrene (MC)...
  3. Liu W, Liu J, Ao L, Zhou Z, Zhou Y, Cui Z, et al. Epigenetic silencing of cell cycle regulatory genes during 3-methylcholanthrene and diethylnitrosamine-induced multistep rat lung cancer. Mol Carcinog. 2010;49:556-65 pubmed publisher
    The rat lung cancers induced by 3-methylcholanthrene (MCA) and diethylnitrosamine (DEN) are considered to be a good model for illustrating genetic alterations in human lung precancerous and cancerous lesions...
  4. Rastogi S, Shukla Y, Paul B, Chowdhuri D, Khanna S, Das M. Protective effect of Ocimum sanctum on 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene and aflatoxin B1 induced skin tumorigenesis in mice. Toxicol Appl Pharmacol. 2007;224:228-40 pubmed
    A study on the protective effect of alcoholic extract of the leaves of Ocimum sanctum on 3-methylcholanthrene (MCA), 7,12-dimethylbenzanthracene (DMBA) and aflatoxin B1 (AFB1) induced skin tumorigenesis in a mouse model has been ..
  5. Laaksonen M, Mäki Paakkanen J, Kronberg L, Komulainen H. Effects of chlorohydroxyfuranones on 3-methylcholanthrene-induced neoplastic transformation in the two-stage transformation assay in C3H 10T1/2 cells. Arch Toxicol. 2003;77:594-600 pubmed
    ..In the latter experiments 3-methylcholanthrene (MC, 5 micro g/ml) was used as the initiating chemical...
  6. Blankenstein T, Qin Z. Chemical carcinogens as foreign bodies and some pitfalls regarding cancer immune surveillance. Adv Cancer Res. 2003;90:179-207 pubmed
    Interferon-gamma-receptor (IFN-gammaR)-deficient mice are more susceptible to tumor induction by methylcholanthrene (MCA) in comparison to control littermates...
  7. Kwon Y, Ueda S, Ueno M, Yodoi J, Masutani H. Mechanism of p53-dependent apoptosis induced by 3-methylcholanthrene: involvement of p53 phosphorylation and p38 MAPK. J Biol Chem. 2002;277:1837-44 pubmed
    Polycyclic aromatic hydrocarbons (PAHs) such as 3-methylcholanthrene (MC) cause untoward effects including carcinogenesis. Here we investigated the effect of MC on apoptosis...
  8. Cretney E, Takeda K, Yagita H, Glaccum M, Peschon J, Smyth M. Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol. 2002;168:1356-61 pubmed
    ..TRAIL gene-targeted mice were also more sensitive to the chemical carcinogen methylcholanthrene. These results substantiated TRAIL as an important natural effector molecule used in the host defense ..
  9. Swann J, Vesely M, Silva A, Sharkey J, Akira S, Schreiber R, et al. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A. 2008;105:652-6 pubmed publisher
    ..13-acetate (TPA)-induced skin papilloma model depends on proinflammatory processes, whereas the 3'-methylcholanthrene (MCA) induction of fibrosarcoma has been used by tumor immunologists to illustrate innate and adaptive ..

More Information

Publications62

  1. Lemaire B, Beck M, Jaspart M, Debier C, Calderon P, Thome J, et al. Precision-Cut Liver Slices of Salmo salar as a tool to investigate the oxidative impact of CYP1A-mediated PCB 126 and 3-methylcholanthrene metabolism. Toxicol In Vitro. 2011;25:335-42 pubmed publisher
    ..PCLS of Salmo salar were exposed for 21 h to increasing doses of 3-methylcholanthrene (3-MC) and Polychlorobiphenyl 126 (PCB 126). 3-MC (25 ?M) strongly induced CYP1A transcription...
  2. Diry M, Tomkiewicz C, Koehle C, Coumoul X, Bock K, Barouki R, et al. Activation of the dioxin/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism. Oncogene. 2006;25:5570-4 pubmed
    ..This novel Ahr action on cell plasticity points to a role in cancer progression. ..
  3. Ronis M, Rowlands J, Hakkak R, Badger T. Inducibility of hepatic CYP1A enzymes by 3-methylcholanthrene and isosafrole differs in male rats fed diets containing casein, soy protein isolate or whey from conception to adulthood. J Nutr. 2001;131:1180-8 pubmed
    ..At age 65 d, rats were gavaged with corn oil (vehicle), 40 mg/kg 3-methylcholanthrene (3-MC) or 75 mg/kg isosafrole (ISO)...
  4. Shankaran V, Ikeda H, Bruce A, White J, Swanson P, Old L, et al. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature. 2001;410:1107-11 pubmed
    ..However, this process also leads to the immunoselection of tumour cells that are more capable of surviving in an immunocompetent host, which explains the apparent paradox of tumour formation in immunologically intact individuals...
  5. Guerra N, Tan Y, Joncker N, Choy A, Gallardo F, Xiong N, et al. NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. Immunity. 2008;28:571-80 pubmed publisher
    ..These findings provide important genetic evidence for surveillance of primary tumors by an NK receptor. ..
  6. Liu W, Ao L, Zhou Z, Cui Z, Zhou Y, Yuan X, et al. CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. Biochem Biophys Res Commun. 2010;402:507-14 pubmed publisher
    ..underlying the tumorigenesis caused by polycyclic aromatic hydrocarbons and nitrosamine compounds such as 3-methylcholanthrene (MCA) and diethylnitrosamine (DEN) are currently unknown...
  7. Finn R, McLaren A, Carrie D, Henderson C, Wolf C. Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system. J Pharmacol Exp Ther. 2007;322:40-7 pubmed
    ..resulted in both hepatic and gastrointestinal deletion of POR, whereas administration of 3-methylcholanthrene resulted specifically in loss of hepatic POR expression...
  8. Smyth M, Swann J, Cretney E, Zerafa N, Yokoyama W, Hayakawa Y. NKG2D function protects the host from tumor initiation. J Exp Med. 2005;202:583-8 pubmed
    ..We show that neutralization of NKG2D enhances the sensitivity of wild-type (WT) C57BL/6 and BALB/c mice to methylcholanthrene (MCA)-induced fibrosarcoma...
  9. Zacharova L, Gulyaeva L, Lyakhovich V, Mikhailova O, Timofeeva O, Filipenko M, et al. Cytochrome P4501A1 and 1A2 gene expression in the liver of 3-methylcholanthrene- and o-aminoazotoluene-treated mice: a comparison between PAH-responsive and PAH-nonresponsive strains. Toxicol Sci. 2003;73:108-13 pubmed
    ..differing in the aryl hydrocarbon receptor (AhR) genotype during treatment with the carcinogenic compounds 3-methylcholanthrene (MC) and o-aminoazotoluene (OAT)...
  10. Chang C, Tsai S, Lin H, Li H, Lee Y, Chou Y, et al. Aryl-hydrocarbon receptor-dependent alteration of FAK/RhoA in the inhibition of HUVEC motility by 3-methylcholanthrene. Cell Mol Life Sci. 2009;66:3193-205 pubmed publisher
    We previously demonstrated the antiproliferative and antiangiogenic effects of 3-methylcholanthrene (3MC), an aryl-hydrocarbon receptor (AhR) agonist, in human umbilical vascular endothelial cells (HUVECs)...
  11. Ozkarsli M, Sevim H, Sen A. In vivo effects of Urtica urens (dwarf nettle) on the expression of CYP1A in control and 3-methylcholanthrene-exposed rats. Xenobiotica. 2008;38:48-61 pubmed
    ..pulmonary, and renal cytochrome P450-dependent monooxygenase activities of rats co-administered with 3-methylcholanthrene (MC)...
  12. Kammertoens T, Qin Z, Briesemeister D, Bendelac A, Blankenstein T. B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-?, perforin). Int J Cancer. 2012;131:1499-508 pubmed publisher
    ..in subtypes of immune cells, cytokines or lytic pathways have been subjected to chemical carcinogenesis by methylcholanthrene to evaluate whether these components of the immune system affect tumor development...
  13. Vikis H, Gelman A, Franklin A, Stein L, Rymaszewski A, Zhu J, et al. Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis. Mol Carcinog. 2012;51:993-1002 pubmed publisher
    ..Inbred mouse strains vary in their susceptibility to methylcholanthrene (MCA)-initiated butylated hydroxytoluene (BHT)-promoted lung carcinogenesis...
  14. Robottom Ferreira A, Aquino S, Queiroga R, Albano R, Ribeiro Pinto L. Expression of CYP2A3 mRNA and its regulation by 3-methylcholanthrene, pyrazole, and beta-ionone in rat tissues. Braz J Med Biol Res. 2003;36:839-44 pubmed
    ..was to analyze CYP2A3 mRNA expression in different rat tissues by RT-PCR, and to study the influence of 3-methylcholanthrene, pyrazole and -ionone treatment on its expression...
  15. Liu W, Liu J, Ao L, Zhou Z, Zhou Y, Cui Z, et al. Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. Toxicol Lett. 2009;189:5-13 pubmed publisher
    3-methylcholanthrene (MCA) and diethylnitrosamine (DEN) are typical genotoxic carcinogens that can induce tumors in a variety of human and rodent tissues. However, the epigenetic mechanisms underlying their tumorigenesis are unclear...
  16. Koebel C, Vermi W, Swann J, Zerafa N, Rodig S, Old L, et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature. 2007;450:903-7 pubmed
    ..These results reveal that, in addition to destroying tumour cells and sculpting tumour immunogenicity, the immune system of a naive mouse can also restrain cancer growth for extended time periods. ..
  17. Pang P, Lin Y, Lee Y, Hou H, Hsu S, Juan S. Molecular mechanisms of p21 and p27 induction by 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, involved in antiproliferation of human umbilical vascular endothelial cells. J Cell Physiol. 2008;215:161-71 pubmed
    We previously reported that 3-methylcholanthrene (3MC), an aryl-hydrocarbon receptor (AhR) agonist, inhibits the proliferation of human umbilical vascular endothelial cells (HUVECs; Juan et al., 2006, Eur J Pharmacol 530: 1-8)...
  18. Liu W, Cui Z, Ao L, Zhou Z, Zhou Y, Yuan X, et al. Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a. Toxicol Appl Pharmacol. 2011;251:70-8 pubmed publisher
    ..genes methylation during lung multistep carcinogenesis induced by the genotoxic carcinogens 3-methylcholanthrene (MCA) and diethylnitrosamine (DEN), tissue samples microdissected from MCA/DEN-induced rat lung ..
  19. Rondini E, Walters D, Bauer A. Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner. Part Fibre Toxicol. 2010;7:9 pubmed publisher
    ..A/J, BALB/cJ (BALB), and C57BL/6J (B6) mice were treated either with the initiator 3-methylcholanthrene (MCA; 10 microg/g; i.p...
  20. Moorthy B, Muthiah K, Fazili I, Kondraganti S, Wang L, Couroucli X, et al. 3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells. Biochem Biophys Res Commun. 2007;354:1071-7 pubmed
    Cytochrome CYP1A (CYP1A) enzymes catalyze bioactivation of 3-methylcholanthrene (MC) to genotoxic metabolites...
  21. Cohen M, Elkabets M, Perlmutter M, Porgador A, Voronov E, Apte R, et al. Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting. J Immunol. 2010;185:5869-78 pubmed publisher
    ..We have shown that in mice with impaired immunoediting, such as in IL-1?(-/-) and IFN?(-/-) mice, 3-methylcholanthrene-induced fibrosarcoma cells are immunogenic and concomitantly bear low levels of surface sialylation, whereas ..
  22. Smyth M, Thia K, Street S, Cretney E, Trapani J, Taniguchi M, et al. Differential tumor surveillance by natural killer (NK) and NKT cells. J Exp Med. 2000;191:661-8 pubmed
    ..critical function for NKT cells in protection from spontaneous tumors initiated by the chemical carcinogen, methylcholanthrene. This is the first description of an antitumor function for NKT cells in the absence of exogenously ..
  23. Fujita Y, Ohi H, Murayama N, Saguchi K, Higuchi S. Molecular cloning and sequence analysis of cDNAs coding for 3-methylcholanthrene-inducible cytochromes P450 in Xenopus laevis liver. Arch Biochem Biophys. 1999;371:24-8 pubmed
    ..for specific cytochrome P450s (CYPs) that would be inducible in response to the administration of either 3-methylcholanthrene (3MC) or beta-naphthoflavone (BNF), potent inducers for mammalian CYP1A...
  24. Wakenell P, O Connell P, Blackmore C, Mondal S, Schat K. Role of Marek's disease herpesvirus in the induction of tumours in Japanese quail (Coturnix coturnix japonica) by methylcholanthrene. Avian Pathol. 2010;39:183-8 pubmed publisher
    The QT35 cell line, established from 20-methylcholanthrene (MCA)-induced tumours in Japanese quail, is positive for Marek's disease virus (MDV), and therefore we examined whether MDV is important for the development of MCA-induced tumours...
  25. Qin Z, Blankenstein T. A cancer immunosurveillance controversy. Nat Immunol. 2004;5:3-4; author reply 4-5 pubmed
  26. Jemnitz K, Veres Z, Monostory K, Vereczkey L. Glucuronidation of thyroxine in primary monolayer cultures of rat hepatocytes: in vitro induction of UDP-glucuronosyltranferases by methylcholanthrene, clofibrate, and dexamethasone alone and in combination. Drug Metab Dispos. 2000;28:34-7 pubmed
    Induction of UDP-glucuronosyltransferases (UGTs) toward thyroxine (T4) and p-nitrophenol (pNP) by 3-methylcholanthrene (MC), dexamethasone (DEX), clofibrate (Cl), and MC combined with DEX or Cl was studied in rat hepatocyte culture...
  27. Keshava N. Tumorigenicity of morphologically distinct transformed foci induced by 3-methylcholanthrene in BALB/c-3T3 cells. Mutat Res. 2000;447:281-6 pubmed
    ..These findings indicate that all five morphologically different foci show tumorigenicity and that any foci of size > or =2 mm regardless of invasiveness and piling could be scored as positive during the cell transformation assay. ..
  28. Dunn G, Bruce A, Sheehan K, Shankaran V, Uppaluri R, Bui J, et al. A critical function for type I interferons in cancer immunoediting. Nat Immunol. 2005;6:722-9 pubmed
    ..Therefore, type I interferons are important components of the cancer immunoediting process and function in a way that does not completely overlap the functions of IFN-gamma. ..
  29. Bhattacharya S, Haldar P. Chemopreventive property of Trichosanthes dioica root against 3-methylcholanthrene-induced carcinogenesis in albino mice. J Environ Pathol Toxicol Oncol. 2012;31:109-19 pubmed
    ..the chemopreventive property of hydroalcoholic extract of the Trichosanthes dioica root (TDA) against 3-methylcholanthrene (3-MC)-induced carcinogenesis in Swiss albino mice...
  30. Smyth M, Crowe N, Godfrey D. NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma. Int Immunol. 2001;13:459-63 pubmed
    ..V(alpha)14J(alpha)281(+) (NKT) cells can be induced by IL-12 therapy to mediate tumor rejection; however, methylcholanthrene (MCA)-induced fibrosarcoma is the only tumor model described where NKT cells play a natural role in ..
  31. Aboutabl M, Zordoky B, El Kadi A. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Br J Pharmacol. 2009;158:1808-19 pubmed publisher
    ..Here, we have investigated the effect of 3-methylcholanthrene (3-MC) and benzo(a)pyrene (BaP), two AhR ligands, on the development of cardiac hypertrophy...
  32. Kondraganti S, Muthiah K, Jiang W, Barrios R, Moorthy B. Effects of 3-methylcholanthrene on gene expression profiling in the rat using cDNA microarray analyses. Chem Res Toxicol. 2005;18:1634-41 pubmed
    ..We reported earlier that exposure of rats to 3-methylcholanthrene (MC) causes sustained induction of hepatic cytochrome P4501A expression for up to 45 days...
  33. Ruud J, Wilhelms D, Nilsson A, Eskilsson A, Tang Y, Ströhle P, et al. Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells. FASEB J. 2013;27:1973-80 pubmed publisher
    ..Instead, we identify MyD88 signaling in hematopoietic/myeloid cells as a critical component for acute inflammatory-driven anorexia, as well as for chronic anorexia and weight loss associated with malignant disease...
  34. Abdelrahim M, Ariazi E, Kim K, Khan S, Barhoumi R, Burghardt R, et al. 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Cancer Res. 2006;66:2459-67 pubmed
    3-Methylcholanthrene (3MC) is an aryl hydrocarbon receptor (AhR) agonist, and it has been reported that 3MC induces estrogenic activity through AhR-estrogen receptor alpha (ER alpha) interactions...
  35. Hayakawa Y, Rovero S, Forni G, Smyth M. Alpha-galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis. Proc Natl Acad Sci U S A. 2003;100:9464-9 pubmed
    ..spanning the time of tumor initiation, inhibits primary tumor formation in three different models: methylcholanthrene-induced sarcomas, mammary carcinomas in Her-2/neu transgenic mice, and spontaneous sarcomas in p53-/- mice...
  36. Pansoy A, Ahmed S, Valen E, Sandelin A, Matthews J. 3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters. Toxicol Sci. 2010;117:90-100 pubmed publisher
    ..of chromatin immunoprecipitation and DNA microarrays (ChIP-chip) to detect AHR-bound genomic regions after 3-methylcholanthrene (3MC) treatment of T-47D human breast cancer cells...
  37. Crowe N, Smyth M, Godfrey D. A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas. J Exp Med. 2002;196:119-27 pubmed
    ..receptor [TCR] Jalpha281-/-) mice, we demonstrate a critical role for NK T cells in immunosurveillance of methylcholanthrene (MCA)-induced fibrosarcomas, in the absence of exogenous stimulatory factors...
  38. Qin Z, Kim H, Hemme J, Blankenstein T. Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction. J Exp Med. 2002;195:1479-90 pubmed
    ..The chemical carcinogen methylcholanthrene (MCA) induces fibrosarcoma and tissue damage in parallel at the injection site...
  39. Ohkawara S, Furuya H, Nagashima K, Asanuma N, Hino T. Effect of oral administration of Butyrivibrio fibrisolvens MDT-1, a gastrointestinal bacterium, on 3-methylcholanthrene-induced tumor in mice. Nutr Cancer. 2007;59:92-8 pubmed
    ..administration of MDT-1 (10(9) cfu/dose, 3 times a wk for 15 wk) delayed the onset of tumors induced by 3-methylcholanthrene and also reduced tumor incidence in mice...
  40. Sozmen M, Tunca R, Dag Erginsoy S. Cyclin A expression is associated with apoptosis and mitosis in murine 3-methylcholanthrene-induced fibrosarcomas. Exp Toxicol Pathol. 2009;61:41-9 pubmed publisher
    ..Cyclin A could be useful for detecting the S phase of the cell cycle and could also indicate that cyclin A may induce S phase arrest associated with apoptosis in the MCA-induced fibrosarcomas. ..
  41. Watanabe H, Shimokado K, Asahara T, Dohi K, Niwa O. Analysis of the c-myc, K-ras and p53 genes in methylcholanthrene-induced mouse sarcomas. Jpn J Cancer Res. 1999;90:40-7 pubmed
    We have examined 63 methylcholanthrene (MCA)-induced mouse sarcomas for possible correlations of mutations involving the c-myc, ras and p53 genes. The c-myc gene was found to be amplified in 18 of these sarcomas (29%)...
  42. Safe S. 3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters. Toxicol Sci. 2010;117:1-3 pubmed publisher
    The paper by Pansoy and coworkers investigates the effects of the aryl hydrocarbon receptor (AHR) ligand 3-methylcholanthrene (3MC) on recruitment of the AHR complex to human promoters in T47D breast cancer cells...
  43. Okey A, Vella L, Harper P. Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene. Mol Pharmacol. 1989;35:823-30 pubmed
    ..mice (prototype, DBA/2) show no significant increase in hepatic P1-450 (P450IA1) when treated with 3-methylcholanthrene or other nonhalogenated polycyclic aromatic hydrocarbons...
  44. Tomita S, Okuyama E, Ohnishi T, Ichikawa Y. Characteristic properties of a retinoic acid synthetic cytochrome P-450 purified from liver microsomes of 3-methylcholanthrene-induced rats. Biochim Biophys Acta. 1996;1290:273-81 pubmed
    ..cytochrome P-450 (P-450) catalyzing retinoic acid synthesis was purified from liver microsomes of 3-methylcholanthrene (3-MC)-treated rats, based on the activity of all-trans-retinoic acid formation from all-trans-retinal...
  45. Flesher J, Horn J, Lehner A. Carcinogenicity of 1-hydroxy-3-methylcholanthrene and its electrophilic sulfate ester 1-sulfooxy-3-methylcholanthrene in Sprague-Dawley rats. Biochem Biophys Res Commun. 1998;243:30-5 pubmed
    Previous experiments have demonstrated that the carcinogen 1-hydroxy-3-methylcholanthrene is a metabolite of 3-methylcholanthrene...
  46. Iyanagi T, Watanabe T, Uchiyama Y. The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation. J Biol Chem. 1989;264:21302-7 pubmed
    ..The Gunn rat is also deficient in a 3-methylcholanthrene (MC)-inducible UDPGT isoenzyme that has high activity toward phenolic substrates...
  47. DuBois G, Law L, Appella E. Purification and biochemical properties of tumor-associated transplantation antigens from methylcholanthrene-induced murine sarcomas. Proc Natl Acad Sci U S A. 1982;79:7669-73 pubmed
    ..antigen with an apparent molecular weight of 75,000 has been isolated from the cytosol of the BALB/c methylcholanthrene-induced sarcoma, Meth A...
  48. Malkinson A, Koski K, Evans W, Festing M. Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene. Cancer Res. 1997;57:2832-4 pubmed
    ..We report that BALB/cOla and BALB/cByJ mice given a low dose (10 microg/g of body weight) of 3-methylcholanthrene (MCA) develop no lung tumors unless this is followed by chronic BHT exposure...
  49. van den Broek M, Kagi D, Ossendorp F, Toes R, Vamvakas S, Lutz W, et al. Decreased tumor surveillance in perforin-deficient mice. J Exp Med. 1996;184:1781-90 pubmed
    ..lines of different tissue origin in naive and primed mice; (b) administration of the chemical carcinogens methylcholanthrene (MCA) or 12-O-tetradecanoylphorbol-13-acetate (TPA) plus 7,12-dimethylbenzanthracene (DMBA), or (c) by ..
  50. Sogawa K, Gotoh O, Kawajiri K, Fujii Kuriyama Y. Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat. Proc Natl Acad Sci U S A. 1984;81:5066-70 pubmed
    The complete nucleotide sequence of the methylcholanthrene-inducible cytochrome P-450c gene was determined by sequence analysis of cloned genomic DNA and the sequence, consisting of 524 amino acids, of the protein was deduced therefrom...
  51. Shimokado K, Watanabe H, Sumii M, Miyagawa K, Kamiya K, Dohi K, et al. p53 gene mutation and loss of heterozygosity of chromosome 11 in methylcholanthrene-induced mouse sarcomas. Jpn J Cancer Res. 1998;89:269-77 pubmed
    ..In this study we examined 63 methylcholanthrene (MCA)-induced sarcomas from C57BL/6N x C3H/HeN F1 (BCF1) or C3H/HeN x C57BL/6N F1 (CBF1) mice for p53 gene ..
  52. Botelho L, Ryan D, Levin W. Amino acid compositions and partial amino acid sequences of three highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, or 3-methylcholanthrene. J Biol Chem. 1979;254:5635-40 pubmed
  53. Halevy O, Rodel J, Peled A, Oren M. Frequent p53 mutations in chemically induced murine fibrosarcoma. Oncogene. 1991;6:1593-600 pubmed
    ..The system described here could potentially be very helpful in elucidating the significance of p53 mutations. ..