emodin

Summary

Summary: Purgative anthraquinone found in several plants, especially Rhamnus frangula. It was formerly used as a laxative, but is now used mainly as tool in toxicity studies.

Top Publications

  1. Muto A, Hori M, Sasaki Y, Saitoh A, Yasuda I, Maekawa T, et al. Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor. Mol Cancer Ther. 2007;6:987-94 pubmed
    b>Emodin is an active component of a traditional Chinese and Japanese medicine isolated from the root and rhizomes of Rheum palmatum L...
  2. Chen R, Jhan J, Su Y, Lee W, Cheng C, Ciou S, et al. Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation. Exp Cell Res. 2009;315:2658-72 pubmed publisher
    b>Emodin, a tyrosine kinase inhibitor, is a natural anthraquinone derivative found in the roots and rhizomes of numerous plants. It reportedly exhibits an anticancer effect on lung cancer...
  3. Gui M, Zhang Y, Xiao Z, Sun P, Dai J, Wang S, et al. Inhibitory effect of emodin on tissue inhibitor of metalloproteinases-1 (TIMP-1) expression in rat hepatic stellate cells. Dig Dis Sci. 2007;52:200-7 pubmed
    b>Emodin inhibited expression of both transforming growth factor beta1 (TGFbeta1)- and phorbol ester (PMA)-induced tissue inhibitors of metalloproteinase-1 (TIMP-1) in an immortalized rat hepatic stellate cell line, HSC-T6, by Western blot ..
  4. Kaneshiro T, Morioka T, Inamine M, Kinjo T, Arakaki J, Chiba I, et al. Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation. Eur J Pharmacol. 2006;553:46-53 pubmed
    An anthraquinone derivative, emodin, suppresses tumor development both in vitro and in vivo...
  5. Liu A, Chen H, Wei W, Ye S, Liao W, Gong J, et al. Antiproliferative and antimetastatic effects of emodin on human pancreatic cancer. Oncol Rep. 2011;26:81-9 pubmed publisher
    b>Emodin (1, 3, 8-trihydroxy-6-methylanthraquinone) is an active constituent isolated from the root of Rheum palmatum L and is the main effective component of some Chinese herbs and plants...
  6. Lee S, Shin H, Min Y, Kim S. Emodin accelerates osteoblast differentiation through phosphatidylinositol 3-kinase activation and bone morphogenetic protein-2 gene expression. Int Immunopharmacol. 2008;8:741-7 pubmed publisher
    b>Emodin is a naturally occurring anthraquinone present in the roots and bark of numerous plants of the genus Rhamnus...
  7. Kovárová M, Bartůnková K, Frantík T, Koblihova H, Prchalová K, Vosatka M. Factors influencing the production of stilbenes by the knotweed, Reynoutria x bohemica. BMC Plant Biol. 2010;10:19 pubmed publisher
    ..We examined whether Reynoutria x bohemica as a medicinal plant providing stilbenes and emodin, can be cultivated in spoil bank substrates and hence in the coalmine spoil banks changed into arable fields...
  8. Gao Q, Wang F, Guo S, Li J, Zhu B, Cheng J, et al. Sonodynamic effect of an anti-inflammatory agent--emodin on macrophages. Ultrasound Med Biol. 2011;37:1478-85 pubmed publisher
    b>Emodin has been used as an anti-inflammatory agent and inflammation is a crucial feature of atherosclerosis. Here, we investigated the sonodynamic effect of emodin on macrophages, the pivotal inflammatory cells in atherosclerotic plaque...
  9. Kim J, Oh D, Cha M, Pyo B, Rhee J, Choy H, et al. Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection. J Microbiol. 2008;46:737-43 pubmed publisher
    ..We confirmed that Polygoni Cuspidati Radix contained high level of emodin by thin layer chromatography (TLC). Emodin showed direct antibacterial activity against V. vulnificus...

More Information

Publications93

  1. Lin M, Lu Y, Su H, Lin H, Lee C, Kang S, et al. Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells. J Cell Biochem. 2011;112:1176-91 pubmed publisher
    ..FaDu (human pharyngeal squamous cell carcinoma), Hep3B (hepatoma), and MG-63 (osteosarcoma) cells induced by aloe-emodin (AE) are p53-independent...
  2. Dorsey J, Kao G. Aloe(-emodin) for cancer? More than just a comforting salve. Cancer Biol Ther. 2007;6:89-90 pubmed
  3. Liu T, Jin H, Sun Q, Xu J, Hu H. Neuroprotective effects of emodin in rat cortical neurons against beta-amyloid-induced neurotoxicity. Brain Res. 2010;1347:149-60 pubmed publisher
    ..In this study, the neuroprotective effect of emodin extracted from the traditional Chinese medicinal herb Polygonum cuspidatum Sieb...
  4. Li D, Zhang N, Cao Y, Zhang W, Su G, Sun Y, et al. Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-?B and MAPKs signal pathways. Eur J Pharmacol. 2013;705:79-85 pubmed publisher
    b>Emodin is an anthraquinone derivative from the Chinese herb Radix et Rhizoma Rhei...
  5. Yang Y, Shang W, Zhou L, Jiang B, Jin H, Chen M. Emodin with PPARgamma ligand-binding activity promotes adipocyte differentiation and increases glucose uptake in 3T3-Ll cells. Biochem Biophys Res Commun. 2007;353:225-30 pubmed
    b>Emodin, one of the main active components in the root and rhizome of Rheum palmatum L, promoted the conversion of 3T3-L1 fibroblasts to adipocytes, as evidenced by increased glycerol-3-phosphate dehydrogenase (GPDH) activity and the ..
  6. Lee Y, Kang O, Choi J, Oh Y, Keum J, Kim S, et al. Synergistic effect of emodin in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. Pharm Biol. 2010;48:1285-90 pubmed publisher
    ..capable of inhibiting this multidrug resistant bacteria, we have investigated the antimicrobial activity of emodin (EM) isolated from Rheum palmatum L. (Polygonaceae) against 17 different strains of the bacterium...
  7. Chen X, Sun R, Hu J, Mo Z, Yang Z, Jin G, et al. Inhibitory effect of emodin on bleomycin-induced pulmonary fibrosis in mice. Clin Exp Pharmacol Physiol. 2009;36:146-53 pubmed publisher
    1. Currently, there is no satisfactory treatment for pulmonary fibrosis. Emodin, a component in Chinese herbs, has been shown to have an antifibrotic effect on pancreatic fibrosis and liver fibrosis...
  8. Wei W, Chen H, Ni Z, Liu H, Tong H, Fan L, et al. Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from Rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation. Int J Oncol. 2011;39:1381-90 pubmed publisher
    ..b>Emodin is an active component of Chinese medicinal herbs and can inhibit the activation of Akt and NF-?B...
  9. Wang R, Wan Q, Zhang Y, Huang F, Yu K, Xu D, et al. Emodin suppresses interleukin-1beta induced mesangial cells proliferation and extracellular matrix production via inhibiting P38 MAPK. Life Sci. 2007;80:2481-8 pubmed
    Previous findings indicate that emodin has anti-proliferation and anti-fibrosis effects on several cell lines...
  10. Fu Z, Han J, Huang H. Effects of emodin on gene expression profile in small cell lung cancer NCI-H446 cells. Chin Med J (Engl). 2007;120:1710-5 pubmed
    ..However, the treatment is limited by the development of drug resistance. Emodin has been shown to exhibit an anti-cancer effect. But the molecular mechanism remains unclear...
  11. Lu Y, Zhang J, Qian J. The effect of emodin on VEGF receptors in human colon cancer cells. Cancer Biother Radiopharm. 2008;23:222-8 pubmed publisher
    This study was designed to evaluate the antiangiogenic properties of emodin and its ability to inhibit tyrosine-kinase-mediated phosphorylation of vascular endothelial growth factor (VEGF) receptors in colon cancer cells...
  12. Xiong H, Luo J, Hou W, Xiao H, Yang Z. The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo. J Ethnopharmacol. 2011;133:718-23 pubmed publisher
    ..Rhubarb is one of the oldest and best-known traditional Chinese medicines. We initiated this study to test if emodin is the active ingredients from Rheum tanguticum (R...
  13. Ding Y, Zhao L, Mei H, Zhang S, Huang Z, Duan Y, et al. Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway. Eur J Pharmacol. 2008;590:377-86 pubmed publisher
    b>Emodin, 1,3,8-trihydroxy-6-methyl-anthraquinone, is an anthraquinone derivative from the roots of Rheum officinale Baill that has been used to treat many diseases in digestive system for thousands of years...
  14. Lee J, Jung E, Lee J, Huh S, Hwang C, Lee H, et al. Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1). Life Sci. 2006;79:2480-5 pubmed
    ..In this study, we found that emodin, an anthraquinone which has been isolated from the rhizome of Rheum palmatum, significantly inhibited TNF alpha-..
  15. Yon J, Baek I, Lee B, Yun Y, Nam S. Emodin and [6]-gingerol lessen hypoxia-induced embryotoxicities in cultured mouse whole embryos via upregulation of hypoxia-inducible factor 1? and intracellular superoxide dismutases. Reprod Toxicol. 2011;31:513-8 pubmed publisher
    ..To determine whether emodin and [6]-gingerol affects hypoxia-induced anomalies during embryonic organogenesis, we cultured embryonic day 8...
  16. Lin S, Lai W, Ho C, Yu F, Chen G, Yang J, et al. Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways. Anticancer Res. 2009;29:327-35 pubmed
    b>Emodin was isolated from Rheum palmatum L. and exhibits an anticancer effect on human cancer cell lines, however, the molecular mechanisms of emodin-mediated apoptosis in human tongue cancer cells have not been fully investigated...
  17. Shuangsuo D, Zhengguo Z, Yunru C, Xin Z, Baofeng W, Lichao Y, et al. Inhibition of the replication of hepatitis B virus in vitro by emodin. Med Sci Monit. 2006;12:BR302-6 pubmed
    b>Emodin (1, 3, 8-trihvdroxy-6-methylanthraquinone) is derived from herbal medicines and proved to have a strong antimicrobial activity. However, its anti-virus effects are less known...
  18. Chen H, Wei W, Guo Y, Liu A, Tong H, Wang Z, et al. Enhanced effect of gemcitabine by emodin against pancreatic cancer in vivo via cytochrome C-regulated apoptosis. Oncol Rep. 2011;25:1253-61 pubmed publisher
    ..b>Emodin, a natural anthraquinone derivative, is one such agent that has been shown to induce apoptosis in other tumor ..
  19. Wang C, Jiang Z, Yao J, Wu X, Sun L, Liu C, et al. Participation of cathepsin B in emodin-induced apoptosis in HK-2 Cells. Toxicol Lett. 2008;181:196-204 pubmed publisher
    b>Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) and rhein (4,5-dihydroxyanthraquinone-2-carboxyl acid) are two main active compounds in total rhubarb anthraquinones (TRAs), which showed nephrotoxicity in Sprague Dawley (S.D...
  20. Dang S, Jia X, Song P, Cheng Y, Zhang X, Sun M, et al. Inhibitory effect of emodin and Astragalus polysaccharide on the replication of HBV. World J Gastroenterol. 2009;15:5669-73 pubmed
    To evaluate the anti-viral effect of emodin plus Astragalus polysaccharide (APS) in hepatitis B virus (HBV) transgenic mice.
  21. Wang X, Zou Y, Sun A, Xu D, Niu Y, Wang S, et al. Emodin induces growth arrest and death of human vascular smooth muscle cells through reactive oxygen species and p53. J Cardiovasc Pharmacol. 2007;49:253-60 pubmed
    ..In this study, we examined the effect of emodin, a natural anthraquinoid compound, on cultured VSMC...
  22. Heo S, Yun H, Noh E, Park S. Emodin and rhein inhibit LIGHT-induced monocytes migration by blocking of ROS production. Vascul Pharmacol. 2010;53:28-37 pubmed publisher
    LIGHT is known to act as a novel mediator for atherogenesis. Furthermore, it has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells...
  23. Cheema S, Gobin A, Rhea R, Lopez Berestein G, Newman R, Mathur A. Silk fibroin mediated delivery of liposomal emodin to breast cancer cells. Int J Pharm. 2007;341:221-9 pubmed
    ..and efficacy of silk fibroin coated liposomes (SF-ELP), encapsulating a receptor tyrosine kinase inhibitor, emodin, on Her2/neu over-expressing breast cancer cells, was investigated...
  24. Crawford A, Liekens S, Kamuhabwa A, Maes J, Munck S, Busson R, et al. Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants. PLoS ONE. 2011;6:e14694 pubmed publisher
    ..Zebrafish bioassay-guided fractionation identified the active components of these plants as emodin, an inhibitor of the protein kinase CK2, and coleon A lactone, a rare abietane diterpenoid with no previously ..
  25. Li X, Dong Y, Wang W, Wang H, Chen Y, Shi G, et al. Emodin as an effective agent in targeting cancer stem-like side population cells of gallbladder carcinoma. Stem Cells Dev. 2013;22:554-66 pubmed publisher
    ..We previously showed that 1,3,8-trihydroxy-6-methylanthraquinone (emodin), a reactive oxygen species (ROS) generator, enhanced sensitivity of gallbladder cancer SGC-996 cells to cisplatin ..
  26. Liu T, Hu H, Sun Q. [Neuroprotective effects of emodin on primary rat cortical neurons apoptosis induced by hydrogen peroxide]. Zhong Yao Cai. 2010;33:1116-9 pubmed
    ..by incubating primary rat cortical neurons in the presence of hydrogen peroxide (H2O2) to study the effect of emodin on apoptosis of nerve cells. Cortical neurons were incubated with H2O2 and emodin...
  27. Lee S, Jeong D, Park W, Kong J, Choi G, Kim H, et al. Screening of Kit inhibitors: suppression of Kit signaling and melanogenesis by emodin. Phytother Res. 2010;24:308-12 pubmed publisher
    ..b>Emodin from the seed of Cassia tora and baicalin from Scutellariae radix showed potent inhibitory effects (IC(50) = 4...
  28. Du Y, Ko K. Effects of pharmacological preconditioning by emodin/oleanolic acid treatment and/or ischemic preconditioning on mitochondrial antioxidant components as well as the susceptibility to ischemia-reperfusion injury in rat hearts. Mol Cell Biochem. 2006;288:135-42 pubmed
    ..I-R) injury, we examined the effect of pharmacological preconditioning by chronic treatment with emodin (EMD)/oleanolic acid (OA) at low dose (25 micromol/kg/day x 15) and/or ischemic preconditioning (IPC) (4 cycles of ..
  29. Chen Y, Chiang S, Lin J, Ma Y, Liao C, Weng S, et al. Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9. Int J Oncol. 2010;36:1113-20 pubmed
    b>Emodin, aloe-emodin and rhein are major compounds in rhubarb (Rheum palmatum L.), used in Chinese herbal medicine, and found to have antitumor properties including cell cycle arrest and apoptosis in many human cancer cells...
  30. Dong M, Jia Y, Zhang Y, Li C, Geng Y, Zhou L, et al. Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation. World J Gastroenterol. 2009;15:4753-62 pubmed
    To investigate the role of emodin in protecting the liver against fibrogenesis caused by carbon tetrachloride (CCl(4)) in rats and to further explore the underlying mechanisms...
  31. Shrimali D, Shanmugam M, Kumar A, Zhang J, Tan B, Ahn K, et al. Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer. Cancer Lett. 2013;341:139-49 pubmed publisher
    b>Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural occurring anthraquinone derivative isolated from roots and barks of numerous plants, molds, and lichens...
  32. Lu H, Lai K, Hsu S, Lin H, Kuo C, Liao C, et al. Involvement of matrix metalloproteinases on the inhibition of cells invasion and migration by emodin in human neuroblastoma SH-SY5Y cells. Neurochem Res. 2009;34:1575-83 pubmed publisher
    b>Emodin (1,3,8-trihydroxy-6-methylanthaquinone), an active component present in the root and rhizome of Rheum palmatum L. (Polygonaceae) has anti-bacterial, anti-tumor, diuretic and vasorelaxant effects...
  33. Tang T, Yin L, Yang J, Shan G. Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats. Eur J Pharmacol. 2007;567:177-85 pubmed
    b>Emodin (1, 3, 8-trihydroxy-6-methyl-anthraquinone) is an anthraquinone derivative from the roots of Rheum officinale Baill, a Chinese herb widely and traditionally used for wound healing...
  34. Park M, Kwon H, Sung M. Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. Biosci Biotechnol Biochem. 2009;73:828-32 pubmed
    ..This study compares the anti-inflammatory effects of aloin and aloe-emodin with other polyphenols...
  35. Ha M, Song Y, Jeong S, Lee H, Jung J, Kim B, et al. Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes. Biol Pharm Bull. 2011;34:1432-7 pubmed
    ..In the present study, we investigated the anti-inflammatory effects of emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) isolated from the root of Rheum palmatum L...
  36. Wang W, Bai Z, Zhang F, Wang C, Yuan Y, Shao J. Synthesis and biological activity evaluation of emodin quaternary ammonium salt derivatives as potential anticancer agents. Eur J Med Chem. 2012;56:320-31 pubmed publisher
    Twenty-six emodin derivatives (17 novel) which attach quaternary ammonium salt were synthesized and evaluated for their anticancer activities in vitro and in vivo...
  37. Zhang C, Wang X, Zhang X, Zhang Y, Xiao H, Liang X. Bioassay-guided separation of citreorosein and other oestrogenic compounds from Polygonum cuspidatum. Phytother Res. 2009;23:740-1 pubmed publisher
    Citreorosein was isolated from P. cuspidatum as a new oestrogenic compound, together with emodin and its glucoside, by silica gel column chromatography and preparative high-performance liquid chromatography sequentially...
  38. He Q, Liu K, Wang S, Hou H, Yuan Y, Wang X. Toxicity induced by emodin on zebrafish embryos. Drug Chem Toxicol. 2012;35:149-54 pubmed publisher
    b>Emodin, a widely available herbal remedy, has a variety of pharmacological actions and valuable clinical applications. The potential effect of emodin on zebrafish (Danio rerio) embryos was evaluated...
  39. Chen G, Liu Z, Wang J, Gao X, Wei L, Liu Y. Protective effect of emodin against lipopolysaccharides-induced corneal injury in rats. Chin Med Sci J. 2009;24:236-40 pubmed
    To investigate the effect of emodin on lipopolysaccharides (LPS)-induced corneal injury in rats...
  40. Pan C, Wang J, Huang N. Preparation, characterization and in vitro anticoagulation of emodin-eluting controlled biodegradable stent coatings. Colloids Surf B Biointerfaces. 2010;77:155-60 pubmed publisher
    In this study, emodin-eluting poly(lactide-co-glycolide) (PLGA) coating stents and emodin-loaded PLGA films were prepared to explore the potential application of emodin-eluting stent for treating cardiovascular disease...
  41. Subramaniam A, Shanmugam M, Ong T, Li F, Perumal E, Chen L, et al. Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3. Br J Pharmacol. 2013;170:807-21 pubmed publisher
    ..Here, we have investigated whether emodin mediates its effect through interference with the STAT3 activation pathway in HCC...
  42. Li Y, Luan Y, Qi X, Li M, Gong L, Xue X, et al. Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II. Toxicol Sci. 2010;118:435-43 pubmed publisher
    b>Emodin, an anthraquinone derived from a plant and fungi, has been reported to possess potential genotoxicity, but the mechanism is not entirely clear...
  43. Tan J, Zhang Q, Huang Z, Chen Y, Wang X, Gu L, et al. Synthesis, DNA binding and cytotoxicity of new pyrazole emodin derivatives. Eur J Med Chem. 2006;41:1041-7 pubmed
    A series of new anthrapyrazoles were derived from emodin by attaching various cationic alkyl amino side chains onto a pyrazole ring which had been incorporated into the anthraquinone chromophore...
  44. Lai J, Chang J, Wen C, Hsu S. Emodin induces a reactive oxygen species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells. Eur J Pharmacol. 2009;623:1-9 pubmed publisher
    b>Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone), a natural anthraquinone compound isolated from the rhizome of rhubarb, has been reported to suppress tumor growth in many clinical situations...
  45. Chen T, Chen M, Qin J, Wang M. [Interventional effects of emodin on transforming growth factor-beta1/integrin-linked kinase signal way in interleukin-1beta-induced transdifferentiation of rat tubular epithelial-myofibroblasts]. Zhong Xi Yi Jie He Xue Bao. 2009;7:59-64 pubmed
    ..IL-1beta)-induced rat tubular epithelial-myofibroblast transdifferentiation (TEMT), and to investigate whether emodin inhibits IL-1beta-induced TEMT through the TGF-beta1/ILK signal way-dependent mechanism...
  46. Jing Y, Yang J, Wang Y, Li H, Chen Y, Hu Q, et al. Alteration of subcellular redox equilibrium and the consequent oxidative modification of nuclear factor kappaB are critical for anticancer cytotoxicity by emodin, a reactive oxygen species-producing agent. Free Radic Biol Med. 2006;40:2183-97 pubmed
    We previously found that emodin produced reactive oxygen species (ROS) intracellularly...
  47. Zheng H, Hu J, Zheng Z, Huang L, Chen Y, Zheng J, et al. [Emodin induces leukemic HL-60 cells apoptosis probably by inhibiting Akt signal pathway]. Yao Xue Xue Bao. 2007;42:1142-6 pubmed
    This study is to investigate the effect of emodin on inducing human myeloid leukemia cell line HL-60 apoptosis and the role of Akt signal pathway in the apoptosis. HL-60 cells were exposed to various dosages of emodin...
  48. Huang X, Wang J, Huang C, Chen Y, Shi G, Hu Q, et al. Emodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: the mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1. Cancer Biol Ther. 2008;7:468-75 pubmed
    ..In the present study, emodin, proven as a reactive oxygen species (ROS) generator by our previous work, was applied in combination with ..
  49. Chu X, Wei M, Yang X, Cao Q, Xie X, Guan M, et al. Effects of an anthraquinone derivative from Rheum officinale Baill, emodin, on airway responses in a murine model of asthma. Food Chem Toxicol. 2012;50:2368-75 pubmed publisher
    b>Emodin is a component from traditional Chinese herbal medicines...
  50. Gao Y, Liu H, Deng L, Zhu G, Xu C, Li G, et al. Effect of emodin on neuropathic pain transmission mediated by P2X2/3 receptor of primary sensory neurons. Brain Res Bull. 2011;84:406-13 pubmed publisher
    ..The P2X(2/3) receptors play a crucial role in facilitating the transmission of pain at neuropathic pain states. Emodin is a natural anthraquinone in rhubarb...
  51. Zhang W, Li H, Bu H, Chen H, Tong H, Liu D, et al. Emodin inhibits the differentiation and maturation of dendritic cells and increases the production of regulatory T cells. Int J Mol Med. 2012;29:159-64 pubmed publisher
    The aim of this study was to characterize the effects of emodin on dendritic cells (DCs) and CD4?CD25? regulatory T cells (Tregs)...
  52. Feng Y, Huang S, Dou W, Zhang S, Chen J, Shen Y, et al. Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br J Pharmacol. 2010;161:113-26 pubmed publisher
    ..b>Emodin, a natural product and active ingredient of various Chinese herbs, has been demonstrated to possess multiple ..
  53. Liu Z, Wei F, Chen L, Xiong H, Liu Y, Luo F, et al. In vitro and in vivo studies of the inhibitory effects of emodin isolated from Polygonum cuspidatum on Coxsakievirus B?. Molecules. 2013;18:11842-58 pubmed publisher
    ..b>Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is one of the natural anthraquinone derivatives obtained from the root ..
  54. Huang Q, Shen H, Shui G, Wenk M, Ong C. Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway. Cancer Res. 2006;66:5807-15 pubmed
    ..b>Emodin is the major active component of the rhizome of Rheum palmatum L., with known anticancer activities...
  55. Chun Guang W, Jun Qing Y, Bei Zhong L, Dan Ting J, Chong W, Liang Z, et al. Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo. Eur J Pharmacol. 2010;627:33-41 pubmed publisher
    b>Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone), a natural anthraquinone derivative isolated from Rheum palmatum L, has been reported to exhibit anti-cancer effect on several human cancers such as liver cancers and lung cancers...
  56. Olsen B, Bjørling Poulsen M, Guerra B. Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action. Int J Biochem Cell Biol. 2007;39:227-37 pubmed
    ..b>Emodin is a natural anthraquinone derivative that exhibits anti-proliferative effects in various cancer cell lines by ..
  57. Heo S, Yun H, Park W, Park S. Emodin inhibits TNF-alpha-induced human aortic smooth-muscle cell proliferation via caspase- and mitochondrial-dependent apoptosis. J Cell Biochem. 2008;105:70-80 pubmed publisher
    ..It has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells; however, it is not known if ..
  58. Song R, Xu F, Zhang Z, Liu Y, Dong H, Tian Y. Structural elucidation of in vitro metabolites of emodin by liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2008;22:1230-6 pubmed publisher
    ..ionization tandem mass spectrometry (LC-ESI-MS/MS) was employed to investigate the in vitro metabolism of emodin. Emodin was incubated with rat liver microsomes in the presence of a NADPH-generating system, followed by ..
  59. Wang X, Gu L, Wu J. Apoptosis-inducing activity of new pyrazole emodin derivatives in human hepatocellular carcinoma HepG2 cells. Biol Pharm Bull. 2007;30:1113-6 pubmed
    A series of new pyrazole derivatives from emodin synthesized in our lab have been shown to have much stronger cytotoxicity than emodin against various tumor cell lines...
  60. Xia X, Wang F, Wang Z, Wan H, Xu W, Lu H. Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis. World J Gastroenterol. 2010;16:2994-3001 pubmed
    To investigate the effect of emodin on expression of claudin-4, claudin-5 and occludin, as well as the alveolar epithelial barrier in rats with pancreatitis induced by sodium taurocholate.
  61. Mizuno M, Kawamura H, Takei N, Nawa H. The anthraquinone derivative Emodin ameliorates neurobehavioral deficits of a rodent model for schizophrenia. J Neural Transm (Vienna). 2008;115:521-30 pubmed publisher
    ..Here we investigated effects of the anthraquinone derivatives emodin (3-methyl-1,6,8-trihydroxyanthraquinone) and sennoside (bis-[D: -glucopyranosyl-oxy]-tetrahydro-4,4'-dihydroxy-..
  62. Yang Y, Yang G. [Effect of emodin on proliferation and differentiation of rat preadipocytes]. Zhongguo Zhong Yao Za Zhi. 2007;32:424-7 pubmed
    To study the effect of emodin (EMO) on the proliferation and differentiation of rat preadipocytes...
  63. Li Z, Xia X, Zhang S, Zhang A, Bo W, Zhou R. Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis. Biomed Pharmacother. 2009;63:120-8 pubmed publisher
    ..b>Emodin, an anthraquinone derivative from Radix et Rhizoma Rhei, and baicalin, a flavone from Scutellaria baicalensis ..
  64. Jelassi B, Anchelin M, Chamouton J, Cayuela M, Clarysse L, Li J, et al. Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors. Carcinogenesis. 2013;34:1487-96 pubmed publisher
    ..b>Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is an anthraquinone derivative originally isolated from Rheum officinale ..
  65. Liu Y, Shen N, Liu C, Lv Y. Immunosuppressive effects of emodin: an in vivo and in vitro study. Transplant Proc. 2009;41:1837-9 pubmed publisher
    We sought to investigate the immunosuppressive effects of emodin and its potential in vivo and in vitro mechanisms...
  66. Srinivas G, Babykutty S, Sathiadevan P, Srinivas P. Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent. Med Res Rev. 2007;27:591-608 pubmed
    Anthraquinones represent a large family of compounds having diverse biological properties. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, molds, ..
  67. Wang G, Sun B, Zhu H, Gao Y, Li X, Xue D, et al. Protective effects of emodin combined with danshensu on experimental severe acute pancreatitis. Inflamm Res. 2010;59:479-88 pubmed publisher
    In the present experiment, we aimed to determine the feasibility and curative effects of emodin combined with danshensu on experimental severe acute pancreatitis (SAP) and the mutual benefit of this synergistic strategy by a prospective ..
  68. Meng G, Liu Y, Lou C, Yang H. Emodin suppresses lipopolysaccharide-induced pro-inflammatory responses and NF-?B activation by disrupting lipid rafts in CD14-negative endothelial cells. Br J Pharmacol. 2010;161:1628-44 pubmed publisher
    b>Emodin [1,3,8-trihydroxy-6-methylanthraquinone] has been reported to exhibit vascular anti-inflammatory properties. However, the corresponding mechanisms are not well understood...
  69. Chen Y, Chiang S, Lin J, Yang J, Ma Y, Liao C, et al. Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells. Anticancer Res. 2010;30:945-51 pubmed
    In our primary studies, we have shown that emodin, aloe-emodin and rhein induced cytotoxic effects, including cell cycle arrest and apoptosis in SCC-4 human tongue cancer cells...
  70. Han Y, Lee S, Jeong D, Ryu S, Han D, Kim D, et al. Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity. Bioorg Med Chem Lett. 2012;22:323-6 pubmed publisher
    ..b>Emodin strongly inhibited phosphatase activity of PRL-3 with IC(50) values of 3...
  71. Wu L, Cai B, Zheng S, Liu X, Cai H, Li H. Effect of emodin on endoplasmic reticulum stress in rats with severe acute pancreatitis. Inflammation. 2013;36:1020-9 pubmed publisher
    This study aimed to investigate the protective effect of emodin on endoplasmic reticulum (ER) stress in rats with severe acute pancreatitis (SAP) and the underlying molecular mechanism...
  72. Hwang J, Noh E, Moon S, Kim J, Kwon K, Park B, et al. Emodin suppresses inflammatory responses and joint destruction in collagen-induced arthritic mice. Rheumatology (Oxford). 2013;52:1583-91 pubmed publisher
    b>Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) is one of the active components present in the root and rhizome of Rheum palmatum...
  73. Lu Y, Yang J, Li X, Hwangbo K, Hwang S, Taketomi Y, et al. Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. Biochem Pharmacol. 2011;82:1700-8 pubmed publisher
    ..b>Emodin, a naturally occurring anthraquinone derivative in oriental herbal medicines, has several beneficial pharmacologic ..
  74. Kitano A, Saika S, Yamanaka O, Ikeda K, Okada Y, Shirai K, et al. Emodin suppression of ocular surface inflammatory reaction. Invest Ophthalmol Vis Sci. 2007;48:5013-22 pubmed
    To determine whether a Chinese herbal medicine component, emodin, suppresses inflammatory/fibrogenic reaction in cultured subconjunctival fibroblasts and reduces injury-induced increases in ocular surface inflammation in mice...
  75. Cai J, Razzak A, Hering J, Saed A, Babcock T, Helton S, et al. Feasibility evaluation of emodin (rhubarb extract) as an inhibitor of pancreatic cancer cell proliferation in vitro. JPEN J Parenter Enteral Nutr. 2008;32:190-6 pubmed publisher
    b>Emodin is a commonly used traditional herbal treatment in China, including use for pancreatic malignancy...
  76. Lu G, Shen H, Chung M, Ong C. Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells. Carcinogenesis. 2007;28:1937-45 pubmed
    Aloe-emodin (AE), one of the main bioactive anthraquinones of Rheum palmatum, possesses potent antitumor properties...
  77. Ma Y, Weng S, Lin M, Lu C, Chiang J, Yang J, et al. Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model. Food Chem Toxicol. 2012;50:1271-8 pubmed publisher
    b>Emodin, an active natural anthraquinone derivative, is found in the roots and rhizomes of numerous Chinese medicinal herbs and exhibits anticancer effects on many types of human cancer cell lines...
  78. Yan Y, Zheng L, Zhang X, Chen L, Singh S, Wang F, et al. Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu. Mol Pharm. 2011;8:1687-97 pubmed publisher
    ..In the present study, we observed that emodin AMAD, a novel emodin azide methyl anthraquinone derivative, extracted from nature's giant knotweed rhizome of ..
  79. Lin H, Lai C, Lee Chao P, Fan S, Tsai Y, Huang S, et al. Aloe-emodin metabolites protected N-methyl-d-aspartate-treated retinal ganglion cells by Cu-Zn superoxide dismutase. J Ocul Pharmacol Ther. 2007;23:152-71 pubmed
    ..Our previous study had found that aloe-emodin sulfates/glucuronides metabolites, an anthraquinone polyphenol, exerted a neuroprotective activity upon RGCs...
  80. Gebhardt R, Lerche K, Götschel F, Gunther R, Kolander J, Teich L, et al. 4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin. J Cell Mol Med. 2010;14:1276-93 pubmed publisher
    ..Using comparative protein kinase assays and molecular docking studies we characterize the emodin-derivative 4-[N-2-(aminoethyl)-amino]-emodin (L4) as a sensitive and potent inhibitor of GSK-3beta with peculiar ..
  81. Li X, Liu W, Wang Q, Liu P, Deng Y, Lan T, et al. Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose. Mol Cell Endocrinol. 2009;307:157-62 pubmed publisher
    Our previous findings demonstrated that emodin could improve the renal function in rats with diabetic nephropathy, but little is known about its molecular mechanisms...
  82. Zhou X, Wang L, Wang M, Xu L, Yu L, Fang T, et al. Emodin-induced microglial apoptosis is associated with TRB3 induction. Immunopharmacol Immunotoxicol. 2011;33:594-602 pubmed publisher
    b>Emodin (1,3,8-trihydroxy-6-methylanthraquinone), a natural anthraquinone compound isolated from the rhizome of rhubarb, has been reported to treat brain injury after intracerebral hemorrhage...
  83. Xue J, Ding W, Liu Y. Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice. Fitoterapia. 2010;81:173-7 pubmed publisher
    Rheum palmatum Linn has been widely applied in the clinical treatment of diabetes mellitus. It has been found that emodin as the major bioactive component of R...
  84. Hsu C, Hsu Y, Tsai Y, Shieh F, Huang S, Wan L, et al. Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells. Biochem Biophys Res Commun. 2010;392:473-8 pubmed publisher
    b>Emodin--a major component of Rheum palmatum L.-exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways...