polymyxin b

Summary

Summary: A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.

Top Publications

  1. Kulesus R, Diaz Perez K, Slechta E, Eto D, Mulvey M. Impact of the RNA chaperone Hfq on the fitness and virulence potential of uropathogenic Escherichia coli. Infect Immun. 2008;76:3019-26 pubmed publisher
    ..vitro, the hfq mutant was significantly impaired in its abilities to handle the antibacterial cationic peptide polymyxin B and reactive nitrogen and oxygen radicals and to grow in acidic medium (pH 5.0)...
  2. Pankey G, Ashcraft D. Detection of synergy using the combination of polymyxin B with either meropenem or rifampin against carbapenemase-producing Klebsiella pneumoniae. Diagn Microbiol Infect Dis. 2011;70:561-4 pubmed publisher
    b>Polymyxin B (PB) plus meropenem (MER) or rifampin (RIF) was tested by Etest® method and time-kill assay (TKA) against 14 genetically unique clinical Klebsiella pneumoniae carbapenemase-producing K. pneumoniae...
  3. Coats S, To T, Jain S, Braham P, Darveau R. Porphyromonas gingivalis resistance to polymyxin B is determined by the lipid A 4'-phosphatase, PGN_0524. Int J Oral Sci. 2009;1:126-35 pubmed publisher
    ..gingivalis), exhibits towards the cationic antimicrobial peptide, polymyxin B. A genetic screen of P...
  4. Elemam A, Rahimian J, Doymaz M. In vitro evaluation of antibiotic synergy for polymyxin B-resistant carbapenemase-producing Klebsiella pneumoniae. J Clin Microbiol. 2010;48:3558-62 pubmed publisher
    ..b>Polymyxin B is one of the few antimicrobials that retain reliable activity against these organisms...
  5. Sakamoto Y, Mashiko K, Obata T, Matsumoto H, Hara Y, Kutsukata N, et al. Relationship between treatment resistance to hemoperfusion using a polymyxin B-immobilized fiber column and oxidative stress. ASAIO J. 2008;54:412-5 pubmed publisher
    ..Recent reports have suggested that direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX) may improve the oxygenation in patients with acute lung injury and acute ..
  6. Zagli G, Bonizzoli M, Spina R, Cianchi G, Pasquini A, Anichini V, et al. Effects of hemoperfusion with an immobilized polymyxin-B fiber column on cytokine plasma levels in patients with abdominal sepsis. Minerva Anestesiol. 2010;76:405-12 pubmed
    ..Use of the technique was associated with lower norepinephrine support and an increased PaO2/FiO2 ratio. ..
  7. Kumagai T, Takeyama N, Yabuki T, Harada M, Miki Y, Kanou H, et al. Apheresis of activated leukocytes with an immobilized polymyxin B filter in patients with septic shock. Shock. 2010;34:461-6 pubmed publisher
    In this study, we examined the effects of direct hemoperfusion through filters with immobilized polymyxin B (PMX-DHP) on leukocyte function and plasma levels of cytokines in patients with septic shock...
  8. Nakamura T, Fujiwara N, Sato E, Kawagoe Y, Ueda Y, Yamada S, et al. Effect of polymyxin B-immobilized fiber hemoperfusion on serum high mobility group box-1 protein levels and oxidative stress in patients with acute respiratory distress syndrome. ASAIO J. 2009;55:395-9 pubmed publisher
    ..b>Polymyxin B-immobilized fiber (PMX-F) hemoperfusion is effective for sepsis-induced ARDS...
  9. Nishibori M, Takahashi H, Katayama H, Mori S, Saito S, Iwagaki H, et al. Specific Removal of Monocytes from Peripheral Blood of Septic Patients by Polymyxin B-immobilized Filter Column. Acta Med Okayama. 2009;63:65-9 pubmed
    Lipopolysaccharide (LPS) is one of the major causes of septic shock. The polymyxin B-immobilized filter column (PMX) was developed for the adsorption of endotoxin by direct hemoperfusion and has been used for the treatment of LPS-induced ..

More Information

Publications62

  1. Satlin M, Kubin C, Blumenthal J, Cohen A, Furuya E, Wilson S, et al. Comparative effectiveness of aminoglycosides, polymyxin B, and tigecycline for clearance of carbapenem-resistant Klebsiella pneumoniae from urine. Antimicrob Agents Chemother. 2011;55:5893-9 pubmed publisher
    ..Hospital from January 2005 through June 2010 to compare microbiologic clearance rates based on the use of polymyxin B, tigecycline, or an aminoglycoside...
  2. Cao G, Ali F, Chiu F, Zavascki A, Nation R, Li J. Development and validation of a reversed-phase high-performance liquid chromatography assay for polymyxin B in human plasma. J Antimicrob Chemother. 2008;62:1009-14 pubmed publisher
    ..specific, sensitive, accurate and reproducible high-performance liquid chromatographic (HPLC) method to measure polymyxin B in human plasma...
  3. Nakamura T, Sugaya T, Koide H. Urinary liver-type fatty acid-binding protein in septic shock: effect of polymyxin B-immobilized fiber hemoperfusion. Shock. 2009;31:454-9 pubmed publisher
    ..protein (L-FABP) levels are altered in patients with septic shock or severe sepsis without shock and whether polymyxin B-immobilized fiber (PMX-F) hemoperfusion affects these levels...
  4. Lee J, Patel G, Huprikar S, Calfee D, Jenkins S. Decreased susceptibility to polymyxin B during treatment for carbapenem-resistant Klebsiella pneumoniae infection. J Clin Microbiol. 2009;47:1611-2 pubmed publisher
  5. Cruz D, Antonelli M, Fumagalli R, Foltran F, Brienza N, Donati A, et al. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA. 2009;301:2445-52 pubmed publisher
    b>Polymyxin B fiber column is a medical device designed to reduce blood endotoxin levels in sepsis. Gram-negative-induced abdominal sepsis is likely associated with high circulating endotoxin...
  6. Cantaluppi V, Assenzio B, Pasero D, Romanazzi G, Pacitti A, Lanfranco G, et al. Polymyxin-B hemoperfusion inactivates circulating proapoptotic factors. Intensive Care Med. 2008;34:1638-45 pubmed publisher
    To test the hypothesis that extracorporeal therapy with polymyxin B (PMX-B) may prevent Gram-negative sepsis-induced acute renal failure (ARF) by reducing the activity of proapoptotic circulating factors...
  7. Hara S, Ishimoto H, Sakamoto N, Mukae H, Kakugawa T, Ishimatsu Y, et al. Direct hemoperfusion using immobilized polymyxin B in patients with rapidly progressive interstitial pneumonias: a retrospective study. Respiration. 2011;81:107-17 pubmed publisher
    ..Direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) was recently identified as an effective treatment for sepsis-associated ..
  8. Cetin E, Tekeli A, Ozseven A, Us E, Aridogan B. Determination of in vitro activities of polymyxin B and rifampin in combination with ampicillin/sulbactam or cefoperazone/sulbactam against multidrug-resistant Acinetobacter baumannii by the E-test and checkerboard methods. Jpn J Infect Dis. 2013;66:463-8 pubmed
    The aim of this study was to investigate the in vitro activities of polymyxin B (PB) and rifampin (RIF) in combination with ampicillin/sulbactam (AS) or cefoperazone/sulbactam (CS) against 20 multidrug-resistant Acinetobacter baumannii (..
  9. Okimura K, Ohki K, Sato Y, Ohnishi K, Sakura N. Semi-synthesis of polymyxin B (2-10) and colistin (2-10) analogs employing the Trichloroethoxycarbonyl (Troc) group for side chain protection of alpha,gamma-diaminobutyric acid residues. Chem Pharm Bull (Tokyo). 2007;55:1724-30 pubmed
    Improved strategies for the chemical conversion of natural polymyxin B and colistin to their N-terminal analogs are reported...
  10. Wang W, Chen I, Jiang S, Chen H, Hsu C, Hsueh P, et al. Role of RppA in the regulation of polymyxin b susceptibility, swarming, and virulence factor expression in Proteus mirabilis. Infect Immun. 2008;76:2051-62 pubmed publisher
    ..causes urinary tract infections, is intrinsically highly resistant to cationic antimicrobial peptides, such as polymyxin B (PB). To explore the mechanisms underlying P...
  11. Urban C, Mariano N, Rahal J. In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin against multidrug-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Antimicrob Agents Chemother. 2010;54:2732-4 pubmed publisher
    In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin were assessed against 20 carbapenem-resistant clinical isolates with different mechanisms of carbapenem resistance...
  12. Overhage J, Campisano A, Bains M, Torfs E, Rehm B, Hancock R. Human host defense peptide LL-37 prevents bacterial biofilm formation. Infect Immun. 2008;76:4176-82 pubmed publisher
    ..detected using subinhibitory concentrations of the mouse peptide CRAMP, which shares 67% identity with LL-37, polymyxin B, or the bovine bactenecin homolog Bac2A...
  13. Pankey G, Ashcraft D. The detection of synergy between meropenem and polymyxin B against meropenem-resistant Acinetobacter baumannii using Etest and time-kill assay. Diagn Microbiol Infect Dis. 2009;63:228-32 pubmed publisher
    Time-kill assay and Etest testing for synergy of meropenem (MER) (1x MIC) plus polymyxin B (1/4, 1/2, and 1x MIC) were performed against 8 genetically unique MER-resistant clinical Acinetobacter baumannii isolates...
  14. Yatera K, Yamasaki K, Kawanami T, Tokuyama S, Ogoshi T, Kouzaki M, et al. A case of successful treatment with polymyxin B-immobilized fiber column direct hemoperfusion in acute respiratory distress syndrome after influenza A infection. Intern Med. 2011;50:601-5 pubmed
    ..influenza A infection who was successfully treated with combined treatment including direct hemoperfusion with polymyxin B-immobilized fiber (PMX-DHP) column...
  15. Abe S, Hayashi H, Seo Y, Matsuda K, Kamio K, Saito Y, et al. Reduction in serum high mobility group box-1 level by polymyxin B-immobilized fiber column in patients with idiopathic pulmonary fibrosis with acute exacerbation. Blood Purif. 2011;32:310-6 pubmed publisher
    Recent reports suggest that polymyxin B (PMX)-immobilized fiber may have beneficial effects in idiopathic pulmonary fibrosis (IPF) with acute exacerbation (AE)...
  16. Rosales Reyes R, Saldías M, Aubert D, El Halfawy O, Valvano M. The suhB gene of Burkholderia cenocepacia is required for protein secretion, biofilm formation, motility and polymyxin B resistance. Microbiology. 2012;158:2315-24 pubmed publisher
    ..In addition, the mutant exhibited increased susceptibility to polymyxin B but not to aminoglycosides such as gentamicin and kanamycin...
  17. Kakugawa T, Mukae H, Saito M, Ishii K, Ishimoto H, Sakamoto N, et al. Rapidly progressive interstitial pneumonia associated with clinically amyopathic dermatomyositis successfully treated with polymyxin B-immobilized fiber column hemoperfusion. Intern Med. 2008;47:785-90 pubmed
    ..We describe a 70-year-old man who presented rapidly progressive interstitial pneumonia associated with clinically ADM (C-ADM); he was successfully treated with polymyxin B-immobilized fiber column (PMX) hemoperfusion.
  18. Zhai B, Zhou H, Yang L, Zhang J, Jung K, Giam C, et al. Polymyxin B, in combination with fluconazole, exerts a potent fungicidal effect. J Antimicrob Chemother. 2010;65:931-8 pubmed publisher
    ..Among selected compounds, the cationic peptide antibiotic polymyxin B was chosen for further characterization because it can be used parenterally and topically...
  19. Dezoti Fonseca C, Watanabe M, Vattimo M. Role of heme oxygenase-1 in polymyxin B-induced nephrotoxicity in rats. Antimicrob Agents Chemother. 2012;56:5082-7 pubmed publisher
    b>Polymyxin B (PMB) is a cationic polypeptide antibiotic with activity against multidrug-resistant Gram-negative bacteria...
  20. Vaara M, Fox J, Loidl G, Siikanen O, Apajalahti J, Hansen F, et al. Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents. Antimicrob Agents Chemother. 2008;52:3229-36 pubmed publisher
    ..Colistin and polymyxin B carry five positive charges...
  21. Ortega X, Silipo A, Saldías M, Bates C, Molinaro A, Valvano M. Biosynthesis and structure of the Burkholderia cenocepacia K56-2 lipopolysaccharide core oligosaccharide: truncation of the core oligosaccharide leads to increased binding and sensitivity to polymyxin B. J Biol Chem. 2009;284:21738-51 pubmed publisher
    ..that the level of core truncation in the mutants was proportional to their increased in vitro sensitivity to polymyxin B (PmB)...
  22. Fern ndez L, Gooderham W, Bains M, McPhee J, Wiegand I, Hancock R. Adaptive resistance to the "last hope" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS. Antimicrob Agents Chemother. 2010;54:3372-82 pubmed publisher
    As multidrug resistance increases alarmingly, polymyxin B and colistin are increasingly being used in the clinic to treat serious Pseudomonas aeruginosa infections...
  23. Felek S, Muszynski A, Carlson R, Tsang T, Hinnebusch B, Krukonis E. Phosphoglucomutase of Yersinia pestis is required for autoaggregation and polymyxin B resistance. Infect Immun. 2010;78:1163-75 pubmed publisher
    ..The DeltapgmA mutant displayed >1,000-fold increased sensitivity to polymyxin B compared to the parental Y. pestis strain, KIM5...
  24. Mogi T, Murase Y, Mori M, Shiomi K, Omura S, Paranagama M, et al. Polymyxin B identified as an inhibitor of alternative NADH dehydrogenase and malate: quinone oxidoreductase from the Gram-positive bacterium Mycobacterium smegmatis. J Biochem. 2009;146:491-9 pubmed publisher
    ..a natural antibiotics library with Mycobacterium smegmatis membrane-bound dehydrogenases and identified polymyxin B (cationic decapeptide) and nanaomycin A (naphtoquinone derivative) as inhibitors of alternative NADH ..
  25. Gales A, Jones R, Sader H. Contemporary activity of colistin and polymyxin B against a worldwide collection of Gram-negative pathogens: results from the SENTRY Antimicrobial Surveillance Program (2006-09). J Antimicrob Chemother. 2011;66:2070-4 pubmed publisher
    To comparatively evaluate the antimicrobial activities of colistin and polymyxin B with those of other antimicrobials against a worldwide collection of 40?625 Gram-negative bacilli...
  26. Ogita A, Konishi Y, Borjihan B, Fujita K, Tanaka T. Synergistic fungicidal activities of polymyxin B and ionophores, and their dependence on direct disruptive action of polymyxin B on fungal vacuole. J Antibiot (Tokyo). 2009;62:81-7 pubmed publisher
    b>Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides...
  27. Ebihara I, Hirayama K, Nagai M, Kakita T, Sakai K, Tajima R, et al. Angiopoietin balance in septic shock patients with acute lung injury: effect of direct hemoperfusion with polymyxin B-immobilized fiber. Ther Apher Dial. 2011;15:349-54 pubmed publisher
    ..Several studies have suggested that angiopoietin-1 and -2 play a contributory role in the pathogenesis of ALI. Polymyxin B-immobilized fiber column hemoperfusion is effective for sepsis-induced ALI...
  28. Zavascki A, Goldani L, Cao G, Superti S, Lutz L, Barth A, et al. Pharmacokinetics of intravenous polymyxin B in critically ill patients. Clin Infect Dis. 2008;47:1298-304 pubmed publisher
    Although not much pharmacokinetic knowledge is available, polymyxin B is increasingly used for treatment of infections caused by gram-negative bacteria that are resistant to all other antibiotics...
  29. Granet D, Dorfman M, Stroman D, Cockrum P. A multicenter comparison of polymyxin B sulfate/trimethoprim ophthalmic solution and moxifloxacin in the speed of clinical efficacy for the treatment of bacterial conjunctivitis. J Pediatr Ophthalmol Strabismus. 2008;45:340-9 pubmed
    To compare the speed of clinical efficacy for two currently available topical antibiotics: polymyxin B sulfate/trimethoprim (polymyxin/trimethoprim) and 0.5% moxifloxacin ophthalmic solution.
  30. Boyen F, Verstappen K, De Bock M, Duim B, Weese J, Schwarz S, et al. In vitro antimicrobial activity of miconazole and polymyxin B against canine meticillin-resistant Staphylococcus aureus and meticillin-resistant Staphylococcus pseudintermedius isolates. Vet Dermatol. 2012;23:381-5, e70 pubmed publisher
    ..Meticillin-resistant Staphylococcus aureus (MRSA) and meticillin-resistant Staphylococcus pseudintermedius (MRSP) infections are increasingly reported in dogs, and these bacteria may be isolated from ear infections...
  31. Tré Hardy M, Vanderbist F, Traore H, Devleeschouwer M. In vitro activity of antibiotic combinations against Pseudomonas aeruginosa biofilm and planktonic cultures. Int J Antimicrob Agents. 2008;31:329-36 pubmed publisher
    ..Among the antibacterial agents tested, tobramycin and polymyxin B had the strongest activity against planktonic cultures when tested alone...
  32. Azad M, Huang J, Cooper M, Roberts K, Thompson P, Nation R, et al. Structure-activity relationships for the binding of polymyxins with human ?-1-acid glycoprotein. Biochem Pharmacol. 2012;84:278-91 pubmed publisher
    ..The binding affinity of colistin, polymyxin B, polymyxin B(3), colistin methansulfonate, and colistin nona-peptide was determined by isothermal titration ..
  33. Cheng H, Chen Y, Peng H. Molecular characterization of the PhoPQ-PmrD-PmrAB mediated pathway regulating polymyxin B resistance in Klebsiella pneumoniae CG43. J Biomed Sci. 2010;17:60 pubmed publisher
    ..the genetic determinants for capsular polysaccharide level and lipopolysaccharide modification involved in polymyxin B resistance of the opportunistic pathogen Klebsiella pneumoniae were characterized...
  34. Jiang S, Liu M, Teng L, Wang W, Hsueh P, Liaw S. Proteus mirabilis pmrI, an RppA-regulated gene necessary for polymyxin B resistance, biofilm formation, and urothelial cell invasion. Antimicrob Agents Chemother. 2010;54:1564-71 pubmed publisher
    Proteus mirabilis is naturally resistant to polymyxin B (PB). To investigate the underlying mechanisms, Tn5 mutagenesis was performed, and a mutant exhibiting increased PB susceptibility was isolated...
  35. Loutet S, Bartholdson S, Govan J, Campopiano D, Valvano M. Contributions of two UDP-glucose dehydrogenases to viability and polymyxin B resistance of Burkholderia cenocepacia. Microbiology. 2009;155:2029-39 pubmed publisher
    ..Only inactivation of ugd(BCAL2946) resulted in increased sensitivity to polymyxin B and this sensitivity could be overcome when either ugd(BCAL2946) or ugd(BCAM0855) but not ugd(BCAM2034) was ..
  36. Abe S, Seo Y, Hayashi H, Matsuda K, Usuki J, Azuma A, et al. Neutrophil adsorption by polymyxin B-immobilized fiber column for acute exacerbation in patients with interstitial pneumonia: a pilot study. Blood Purif. 2010;29:321-6 pubmed publisher
    b>Polymyxin B-immobilized fiber (PMX) treatment has beneficial effects in patients with acute lung injury/acute respiratory distress syndrome or acute exacerbation of idiopathic pulmonary fibrosis...
  37. Pietschmann S, Hoffmann K, Voget M, Pison U. Synergistic effects of miconazole and polymyxin B on microbial pathogens. Vet Res Commun. 2009;33:489-505 pubmed publisher
    ..To assess the value of an antibiotic combination of polymyxin B and miconazole this study examined the in vitro synergistic potential of the two drugs on Gram-negative and ..
  38. Dohar J, Roland P, Wall G, McLean C, Stroman D. Differences in bacteriologic treatment failures in acute otitis externa between ciprofloxacin/dexamethasone and neomycin/polymyxin B/hydrocortisone: results of a combined analysis. Curr Med Res Opin. 2009;25:287-91 pubmed
    ..3%/dexamethasone 0.1% (CDex) or neomycin 0.35%/polymyxin B 10,000 IU/mL/hydrocortisone 1% (Cort) based on clinical and microbiological failure in patients positive for ..
  39. Novelli G, Ferretti G, Poli L, Pretagostini R, Ruberto F, Perrella S, et al. Clinical results of treatment of postsurgical endotoxin-mediated sepsis with polymyxin-B direct hemoperfusion. Transplant Proc. 2010;42:1021-4 pubmed publisher
    ..Despite the small number of patients included in the study, the encouraging results suggest that PMX-DHP is a useful therapeutic strategy for lowering sepsis-related mortality. ..
  40. Mitrophanov A, Jewett M, Hadley T, Groisman E. Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria. PLoS Genet. 2008;4:e1000233 pubmed publisher
    ..the transition between direct and indirect regulatory pathways governing inducible resistance to the antibiotic polymyxin B in enteric bacteria...
  41. Barchiesi J, Espariz M, Checa S, Soncini F. Downregulation of RpoN-controlled genes protects Salmonella cells from killing by the cationic antimicrobial peptide polymyxin B. FEMS Microbiol Lett. 2009;291:73-9 pubmed publisher
    Salmonella enterica polymyxin B (PM) resistance is modulated mainly by substitutions of the acyl chains and the phosphate groups on the lipid A moiety of lipopolysaccharide...
  42. Stichtenoth G, Linderholm B, Björkman M, Walter G, Curstedt T, Herting E. Prophylactic intratracheal polymyxin B/surfactant prevents bacterial growth in neonatal Escherichia coli pneumonia of rabbits. Pediatr Res. 2010;67:369-74 pubmed publisher
    ..Previously, we have shown that addition of the antimicrobial peptide polymyxin B (PxB) to modified porcine surfactant (pSF) improves resistance to surfactant inactivation in vitro while ..
  43. Park S, Chibli H, Wong J, Nadeau J. Antimicrobial activity and cellular toxicity of nanoparticle-polymyxin B conjugates. Nanotechnology. 2011;22:185101 pubmed publisher
    ..the antimicrobial activity and cytotoxicity to mammalian cells of conjugates of the peptide antibiotic polymyxin B (PMB) to Au nanoparticles and CdTe quantum dots...
  44. Ono S, Kimura A, Hiraki S, Takahata R, Tsujimoto H, Kinoshita M, et al. Removal of increased circulating CD4+CD25+Foxp3+ regulatory T cells in patients with septic shock using hemoperfusion with polymyxin B-immobilized fibers. Surgery. 2013;153:262-71 pubmed publisher
    ..with sepsis, little is known about regulatory T cell (Treg)-mediated immunosuppression and the effect of polymyxin B-immobilized fiber (PMX-F) on sepsis-induced immunosuppression...
  45. Totsugawa T, Kuinose M, Yoshitaka H, Tsushima Y, Ishida A, Chikazawa G, et al. Intraoperative direct hemoperfusion with a polymyxin-B immobilized fiber column for treatment of infective endocarditis. Gen Thorac Cardiovasc Surg. 2011;59:98-104 pubmed publisher
    ..Intraoperative PMX-DHP can be a useful option for the treatment of critically ill patients with IE. ..
  46. Barrow K, Kwon D. Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2009;53:5150-4 pubmed publisher
    ..We examined five clonally unrelated clinical isolates of polymyxin B-resistant P. aeruginosa to investigate the molecular basis of polymyxin resistance...
  47. Hankins J, Madsen J, Giles D, Brodbelt J, Trent M. Amino acid addition to Vibrio cholerae LPS establishes a link between surface remodeling in gram-positive and gram-negative bacteria. Proc Natl Acad Sci U S A. 2012;109:8722-7 pubmed publisher
    ..classical biotypes of Vibrio cholerae have been differentiated by their resistance to the antimicrobial peptide polymyxin B. However, the molecular mechanisms associated with this phenotypic distinction have remained a mystery for 50 y...
  48. Jiang S, Lin T, Wang W, Liu M, Hsueh P, Liaw S. Characterization of UDP-glucose dehydrogenase and UDP-glucose pyrophosphorylase mutants of Proteus mirabilis: defectiveness in polymyxin B resistance, swarming, and virulence. Antimicrob Agents Chemother. 2010;54:2000-9 pubmed publisher
    Proteus mirabilis is known to be highly resistant to the action of polymyxin B (PB). However, the mechanism underlying PB resistance is not clear...
  49. Takahashi G, Hoshikawa K, Matsumoto N, Shozushima T, Onodera C, Kan S, et al. Changes in serum S100A12 and sRAGE associated with improvement of the PaO(2)/FiO(2) ratio following PMX-DHP therapy for postoperative septic shock. Eur Surg Res. 2011;47:135-40 pubmed publisher
    Endotoxin (Et) adsorption therapy with a column of polymyxin B-immobilized fibers (PMX) is effective in improving the partial pressure of arterial oxygen/fraction of inspired oxygen ratio (PaO(2)/FiO(2) ratio) and increasing mean ..
  50. Cappelli C, Lopez X, Labra Y, Montoya M, Fernandez R, Imarai M, et al. Polymyxin B increases the depletion of T regulatory cell induced by purinergic agonist. Immunobiology. 2012;217:307-15 pubmed publisher
    ..Our aim was to determine whether polymyxin B (PMB), which is a positive modulator of this receptor, could affect mice Treg depletion by ATP and related ..
  51. Hamad M, Di Lorenzo F, Molinaro A, Valvano M. Aminoarabinose is essential for lipopolysaccharide export and intrinsic antimicrobial peptide resistance in Burkholderia cenocepacia(†). Mol Microbiol. 2012;85:962-74 pubmed publisher
    ..The mutants also become highly sensitive to polymyxin B and melittin, two different classes of antimicrobial peptides...
  52. Taniguchi T, Sato K, Kurita A, Noda T, Okajima M. Efficacy of endotoxin adsorption therapy (polymyxin B hemoperfusion) for methicillin-resistant Staphylococcus aureus toxic shock syndrome: a case report about five patients. Minerva Anestesiol. 2013;79:758-61 pubmed
    ..In this study, we evaluated the effects of endotoxin adsorption therapy (polymyxin B [PMX] hemoperfusion) in critical patients with methicillin-resistant Staphylococcus aureus TSS (MRSA-TSS) who ..
  53. Urakawa H, Yamada K, Komagoe K, Ando S, Oku H, Katsu T, et al. Structure-activity relationships of bacterial outer-membrane permeabilizers based on polymyxin B heptapeptides. Bioorg Med Chem Lett. 2010;20:1771-5 pubmed publisher
    A series of cationic cyclic heptapeptides based on polymyxin B have been synthesized for use as permeabilizers of the outer membrane of Gram-negative bacteria...