withanolides

Summary

Summary: Ergostane derivatives of 28 carbons with oxygens at C1, C22, and C26 positions and the side chain cyclized. They are found in WITHANIA plant genus and have cytotoxic and other effects.

Top Publications

  1. Yan X, Huang G, Liu Q, Zheng J, Chen H, Huang Q, et al. Withaferin A protects against spinal cord injury by inhibiting apoptosis and inflammation in mice. Pharm Biol. 2017;55:1171-1176 pubmed publisher
    ..37?±?1.17?pg/mL) and IL-10 (116.80?±?6.91?pg/mL vs. 72.33?±?9.35?pg/mL) were elevated after WFA administration. This study demonstrated that WFA has a neuroprotective role by inhibition of apoptosis and inflammation after SCI in mice. ..
  2. Singh P, Guleri R, Angurala A, Kaur K, Kaur K, Kaul S, et al. Addressing Challenges to Enhance the Bioactives of Withania somnifera through Organ, Tissue, and Cell Culture Based Approaches. Biomed Res Int. 2017;2017:3278494 pubmed publisher
    ..The present review highlights the developments and sketches current scenario in this field. ..
  3. Hou W, Miao X, Ma L, Bai X, Liu Q, Song L. WITHAFERIN A INDUCES APOPTOSIS IN RAT C6 GLIOMA CELLS THROUGH REGULATING NF-KB NUCLEAR TRANSLOCATION AND ACTIVATION OF CASPASE CASCADE. Afr J Tradit Complement Altern Med. 2017;14:319-324 pubmed publisher
    ..The outcome of this study evidently demonstrates that C6 glioma cells co-cultured with increased concentration of WFA, showed an anti-proliferative, anti-inflammatory and pro-apoptotic effect in a dose-dependent fashion. ..
  4. Xu Y, Wijeratne E, Babyak A, Marks H, Brooks A, Tewary P, et al. Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells. J Nat Prod. 2017;80:1981-1991 pubmed publisher
    Investigation of aeroponically grown Physalis peruviana resulted in the isolation of 11 new withanolides, including perulactones I-L (1-4), 17-deoxy-23?-hydroxywithanolide E (5), 23?-hydroxywithanolide E (6), 4-deoxyphyperunolide A (7), 7?..
  5. Ma T, Zhang Y, Zhang C, Luo J, Kong L. Downregulation of TIGAR sensitizes the antitumor effect of physapubenolide through increasing intracellular ROS levels to trigger apoptosis and autophagosome formation in human breast carcinoma cells. Biochem Pharmacol. 2017;143:90-106 pubmed publisher
    ..Taken together, these results indicate that downregulation of TIGAR increased PB-induced apoptosis and autophagosomes associated cell death through promoting ROS generation in MDA-MB-231 and MCF-7 cells. ..
  6. Llanos G, Araujo L, Jimenez I, Moujir L, Rodriguez J, Jimenez C, et al. Structure-based design, synthesis, and biological evaluation of withaferin A-analogues as potent apoptotic inducers. Eur J Med Chem. 2017;140:52-64 pubmed publisher
    ..The potent capacity to induce apoptosis with concomitant cell loss in G2/M highlights the potential of 27-benzyl analogue (18) as an apoptotic inducer drug candidate. ..
  7. Li A, Sun M, Li X. Withaferin-A induces apoptosis in osteosarcoma U2OS cell line via generation of ROS and disruption of mitochondrial membrane potential. Eur Rev Med Pharmacol Sci. 2017;21:1368-1374 pubmed
    ..We suggest that WF-A may prove a potent therapeutic agent for inducing apoptosis in osteosarcoma cell lines via generation of ROS and disruption of mitochondrial membrane potential. ..
  8. Yu Y, Katiyar S, Sundar D, Kaul Z, Miyako E, Zhang Z, et al. Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences. Cell Death Dis. 2017;8:e2755 pubmed publisher
    ..The results suggest that Wi-A could be a new candidate drug for ALT cancers. ..
  9. Kunimasa K, Nagano T, Shimono Y, Dokuni R, Kiriu T, Tokunaga S, et al. Glucose metabolism-targeted therapy and withaferin A are effective for epidermal growth factor receptor tyrosine kinase inhibitor-induced drug-tolerant persisters. Cancer Sci. 2017;108:1368-1377 pubmed publisher
    ..Withaferin A effectively eliminated the CD133high cell population. The combination of phloretin and withaferin A effectively suppressed gefitinib-resistant tumor growth. ..

More Information

Publications13

  1. Falkenberg K, Jakobs A, Matern J, Dörner W, Uttarkar S, Trentmann A, et al. Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C/EBP?. Biochim Biophys Acta Mol Cell Res. 2017;1864:1349-1358 pubmed publisher
    ..The finding that WFA is a potent inhibitor of C/EBP? suggests that inhibition of C/EBP? might contribute to the biological activities of WFA. ..
  2. Su Y, Wang Q, Yang B, Wu L, Cheng G, Kuang H. Withasteroid B from D. metel L. regulates immune responses by modulating the JAK/STAT pathway and the IL-17+ ROR?t+ /IL-10+ FoxP3+ ratio. Clin Exp Immunol. 2017;190:40-53 pubmed publisher
    ..These findings suggest that B2 might mediate the therapeutic effects observed in psoriasis patients following treatment with D. metel L. ..
  3. Huang C, Ahmed A, Su J, Sung P, Hwang T, Chiang P, et al. Bioactive new withanolides from the cultured soft coral Sinularia brassica. Bioorg Med Chem Lett. 2017;27:3267-3271 pubmed publisher
    ..study of the ethyl acetate (EtOAc) extract of the cultured soft coral Sinularia brassica afforded five new withanolides, sinubrasolides H-L (1-5)...
  4. Sheremet M, Kapoor S, Schröder P, Kumar K, Ziegler S, Waldmann H. Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling. Chembiochem. 2017;18:1797-1806 pubmed publisher
    ..This natural-product-inspired compound library contained potent inhibitors of Wnt signaling that act upstream of the destruction complex to stabilize Axin in a tankyrase-independent manner. ..